ࡱ> %` xbjbjNN .,,a (DDDD D,(WFFFFFGGGWWWWWWW$XhG[@WEHGGHH@WFFWJJJH*FFWJHWJJJFF PJDI JFJ W0WJ[I[J[J4G"GJ HHGGG@W@WIGGGWHHHH(((37 (((7(((  Supplemental Table 1 Kinase inhibition profile of resveratrol (20M) NoKinaseActivity (% of Control)NoKinaseActivity ( % of Control)1Abl(h)105 751MST2(h)73 82Abl(T315I)(h)100 252NEK2(h)102 43ALK(h)39 053NEK3(h)96 84ALK4(h)110 354NEK6(h)140 165AMPK(r)39 255NEK7(h)116 26Aurora-A(h)65 1 56NLK (h)30 27CDK1/cyclinB(h)67 357p70S6K(h)21 18CDK2/cyclinA(h)80 158PAK2(h)98 49CDK2/cyclinE(h)80 059PAK3(h)46 010CDK3/cyclinE(h)75 460PAK4(h)103 411CDK5/p25(h)64 4 61PAK6(h)103 312CDK5/p35(h)77 262PDGFR(h)114 213CDK6/cyclinD3(h)55 263PDGFR(h)119 214CDK7/cyclinH/MAT1(h)95 164PDK1(h)108 715CDK9/cyclin T1(h)70 365PI 3-Kinase(h)107 116CHK1(h)95 266PI 3-Kinase(h)101 117CHK2(h)59 667PI 3-Kinase(h)106 118cKit(h)68 068Pim-1(h)6 219CSK(h)94 569Pim-2(h)14 220cSRC(h)61 170PKA(h)100 021DAPK1(h)71 371PKB(h)94 2 22DAPK2(h)67 772PKB(h)105 323EGFR(h)90 573PKB(h)89 424EphB2(h)113 174PKC(h)114 925FGFR1(h)58 275PKCI(h)103 526Fgr(h)78 576PKC(h)80 827Flt1(h)52 177PKC(h)92 128Flt3(h)41 178PKC(h)99 529Fms(h)61 279PKC(h)89 030GSK3(h)79 480PKD2(h)88 531GSK3(h)92 081PKG1(h)56 432IGF-1R(h)75 082Plk3(h)95 933IKK(h)40 183Ros(h)102 434IKK( HrBwxxxh$aCJaJhmhmCJaJUhchmCJaJhmhm5CJaJhOK5CJaJh hmCJaJ HKRjknu $Ifgdm $$Ifa$gdmgdm 0^`0gdm xJ>5>5> $Ifgdm $$Ifa$gdmkd$$IfTl֞`h t"x t"44 laT5kd$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm5kd$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm $$Ifa$gdm $Ifgdm       J>5>5> $Ifgdm $$Ifa$gdmkd$$IfTl֞`h t"x t"44 laT # , - / 7 > 5kd $$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm> ? B J R S U 5kd!$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $IfgdmU a i j m u | $$Ifa$gdm $Ifgdm| }  J>5>5> $Ifgdm $$Ifa$gdmkd"$$IfTl֞`h t"x t"44 laT 5kd#$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm 5kd$$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm $$Ifa$gdm $Ifgdm  2 @ B H J>5>5> $Ifgdm $$Ifa$gdmkd% $$IfTl֞`h t"x t"44 laTH X h j p 5kd& $$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm 5kd' $$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm  $$Ifa$gdm $Ifgdm  " D R T Z J>5>5> $Ifgdm $$Ifa$gdmkd( $$IfTl֞`h t"x t"44 laTZ n ~ 5kd) $$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm 5kd*$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm  " ( H X $$Ifa$gdm $IfgdmX Z ` p ~ J>5>5> $Ifgdm $$Ifa$gdmkd+$$IfTl֞`h t"x t"44 laT 5kd,$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm     5kd-$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm , : < B T ` $$Ifa$gdm $Ifgdm` b h v J>5>5> $Ifgdm $$Ifa$gdmkd.$$IfTl֞`h t"x t"44 laT 5kd/$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm 5kd0$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm "(8H $$Ifa$gdm $IfgdmHJPbprxJ>5>5> $Ifgdm $$Ifa$gdmkd1$$IfTl֞`h t"x t"44 laTx5kd2$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm5kd3$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm&6 $$Ifa$gdm $Ifgdm68>P^`fJ>5>5> $Ifgdm $$Ifa$gdmkd4$$IfTl֞`h t"x t"44 laTfx5kd5$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm5kd6$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm $$Ifa$gdm $Ifgdm &6DFLJ>5>5> $Ifgdm $$Ifa$gdmkd7$$IfTl֞`h t"x t"44 laTL\jlr5kd8$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm5kd9$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm $$Ifa$gdm $Ifgdm *,2J>5>5> $Ifgdm $$Ifa$gdmkd:$$IfTl֞`h t"x t"44 laT2DRTZn|5kd;$$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm|~5kd< $$IfTl֞`h t"x t"44 laT $$Ifa$gdm $Ifgdm $$Ifa$gdm $IfgdmrrrrJ>5>5> $Ifgdm $$Ifa$gdmkd=!$$IfTl֞`h t"x t"44 laTh)116 284Rsk1(h)70 135IR(h)71 585Rsk2(h)32 036IRR(h)40 086SAPK2a(h)100 4 37IRAK1(h)97 087SAPK2a(T106M)(h)102 238JAK2(h)27 588SAPK2b(h)100 139JNK11(h)89 589SAPK3(h)110 540JNK22(h)110 490SAPK4(h)92 441JNK3(h)98 391SGK(h)86 1342LIMK1(h)84 492SGK2(h)70 143LKB1(h)102 393SIK(h)76 144MAPK1(h)94 1394Snk(h)81 345MAPK2(h)101 1095TAK1(h)105 346MEK1(h)110 596TBK1(h)62 447Met(h)114 597Tie2(h)94 848MSK1(h)58 198TrkA(h)31 349MSK2(h)60 199TrkB(h)98 150MST1(h)75 6100ZAP-70(h)141 2Data set was performed in duplicate and represented as activity as a percent of DMSO control standard deviation. 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