ࡱ> GF ZO\pVelveene 09 Ba==;MgK<8X@"1Calibri1Calibri1Calibri1Calibri1Calibri1 Calibri1Calibri14Calibri1 Calibri1Calibri1Calibri1,6Calibri16Calibri16Calibri1>Calibri14Calibri1<Calibri1?Calibri1*h6 Calibri Light1Calibri1 Calibri"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_) #,##0\ "kr.";\-#,##0\ "kr."% #,##0\ "kr.";[Red]\-#,##0\ "kr."&!#,##0.00\ "kr.";\-#,##0.00\ "kr."+&#,##0.00\ "kr.";[Red]\-#,##0.00\ "kr."A<_-* #,##0\ "kr."_-;\-* #,##0\ "kr."_-;_-* "-"\ "kr."_-;_-@_-,'_-* #,##0_-;\-* #,##0_-;_-* "-"_-;_-@_-ID_-* #,##0.00\ "kr."_-;\-* #,##0.00\ "kr."_-;_-* "-"??\ "kr."_-;_-@_-4/_-* #,##0.00_-;\-* #,##0.00_-;_-* "-"??_-;_-@_-                                                                       ff         P@ @  P@ @  @       `@ @            a@ >    ||?bo}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-} _-;_-* "}-} _-;_-* "}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef ?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L ?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A}  _-;_-* "23?\ "kr."}A}! _-;_-* "23 ?\ "kr."}A}" _-;_-* "?\ "kr."}A}# _-;_-* "?\ "kr."}A}$ _-;_-* "?\ "kr."}A}% _-;_-* "?\ "kr."}A}& _-;_-* "?\ "kr."}A}' _-;_-* " ?\ "kr."}A}( _-;_-* "?\ "kr."}}) }_-;_-* "?\ "kr."   }}* _-;_-* "?\ "kr."??? ??? ??? ???}-}+ _-;_-* "}-}, _-;_-* "}-}- _-;_-* "}-}. _-;_-* "}-}/ _-;_-* "}A}0 a_-;_-* "?\ "kr."}A}1 _-;_-* "?\ "kr."}A}2 _-;_-* "??\ "kr."}A}3 _-;_-* "23?\ "kr."}-}4 _-;_-* "}}5 ??v_-;_-* "̙?\ "kr."   }A}6 }_-;_-* "?\ "kr."}A}7 W_-;_-* "?\ "kr."}}8 _-;_-* "?\ "kr."   }}9 ???_-;_-* "?\ "kr."??? ??? ??? ???}-}: _-;_-* "}-}; _-;_-* "}U}< _-;_-* "?\ "kr." }-}= _-;_-* "}-}> _-;_-* " 20% - Accent1M 20% - Accent1 ef % 20% - Accent2M" 20% - Accent2 ef % 20% - Accent3M& 20% - Accent3 ef % 20% - Accent4M* 20% - Accent4 ef % 20% - Accent5M. 20% - Accent5 ef % 20% - Accent6M2 20% - Accent6  ef % 40% - Accent1M 40% - Accent1 L % 40% - Accent2M# 40% - Accent2 L˭ % 40% - Accent3M' 40% - Accent3 L % 40% - Accent4M+ 40% - Accent4 L % 40% - Accent5M/ 40% - Accent5 L % 40% - Accent6M3 40% - Accent6  L % 60% - Accent1M 60% - Accent1 23 % 60% - Accent2M$ 60% - Accent2 23 % 60% - Accent3M( 60% - Accent3 23 % 60% - Accent4M, 60% - Accent4 23f % 60% - Accent5M0 60% - Accent5 23 %! 60% - Accent6M4 60% - Accent6  23Ў % "Accent1AAccent1 Dr % #Accent2A!Accent2 }1 % $Accent3A%Accent3  % %Accent4A)Accent4  % &Accent5A-Accent5 [ % 'Accent6A1Accent6  pG %(Bad9Bad  %) Calculation Calculation  }% * Check Cell Check Cell  %????????? ???+ Comma,( Comma [0]-&Currency.. Currency [0]/Explanatory TextG5Explanatory Text % 0Good;Good  a%1 Heading 1G Heading 1 DTj%Dr2 Heading 2G Heading 2 DTj%?3 Heading 3G Heading 3 DTj%234 Heading 49 Heading 4 DTj% 5InputuInput ̙ ??v% 6 Linked CellK Linked Cell }% 7NeutralANeutral  W%3Normal % 8Noteb Note   9OutputwOutput  ???%????????? ???:$Percent ;Title1Title DTj% <TotalMTotal %DrDr= Warning Text? Warning Text %XTableStyleMedium2PivotStyleLight16`#xLgroup_4_overlap_up_pathways \down5UQNestor-Guillermo progeriaSeckel syndromeidnumSignalling to ERK5.R-HSA-198765)Acyl chain remodeling of CL.R-HSA-1482798*Acyl chain remodelling of PC.R-HSA-1482788@Metabolism of ingested H2SeO4 and H2SeO3 into H2Se.R-HSA-2408550!Metabolism of lipids.R-HSA-5568339Neurophilin interactions with VEGF and VEGFR.R-HSA-1943064Non-integrin membrane-ECM interactions.R-HSA-3000171$Organic anion transport.R-HSA-561048Purine catabolism.R-HSA-74259*Sulfide oxidation to sulfate.R-HSA-1614517#Syndecan interactions.R-HSA-3000170?Synthesis of 12-eicosatetraenoic acid derivatives.R-HSA-2142712?Synthesis of 15-eicosatetraenoic acid derivatives.R-HSA-21427703Synthesis of 5-eicosatetraenoic acids.R-HSA-2142688Synthesis of PG.R-HSA-1483148Synthesis of PS.R-HSA-14831011Vitamin B5 (pantothenate) metabolism.R-HSA-199220!phospho-PLA2 pathway.R-HSA-111995IEvents associated with phagocytolytic activity of PMN cells.R-HSA-8941413Lysine catabolism.R-HSA-71064#Invadopodia formation.R-HSA-89412376IRAK2 mediated activation of TAK1 complex.R-HSA-937042.Biosynthesis of EPA-derived SPMs.R-HSA-9018679*Acyl chain remodelling of PE.R-HSA-1482839.Alternative complement activation.R-HSA-1737360Biosynthesis of D-series resolvins.R-HSA-9018676.Biosynthesis of DHA-derived SPMs.R-HSA-9018677<Biosynthesis of DHA-derived sulfido conjugates.R-HSA-90263956Biosynthesis of E-series 18(R)-resolvins.R-HSA-90236616Biosynthesis of E-series 18(S)-resolvins.R-HSA-9018896BBiosynthesis of aspirin-triggered D-series resolvins.R-HSA-9020265SIRAK2 mediated activation of TAK1 complex upon TLR7-8 or 9 stimulation.R-HSA-975163fBiosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR).R-HSA-9026766GBiosynthesis of specialized proresolving mediators (SPMs).R-HSA-9018678$Coenzyme A biosynthesis.R-HSA-196783ECM proteoglycans.R-HSA-30001785Formation of selenosugars for excretion.R-HSA-2408499,Glycerophospholipid catabolism.R-HSA-6814848Hydrolysis of LPC.R-HSA-14831155Transfer of LPS from LBP carrier to CD14.R-HSA-1660203ATF6 (ATF6-alpha) activates chaperones.R-HSA-3810333Activated NTRK3 signals through PLCG1.R-HSA-9034793'Signaling by NTRK3 (TRKC).R-HSA-9034015GSynthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).R-HSA-21428167TCF dependent signaling in response to WNT.R-HSA-201681.TET1,2,3 and TDG demethylate DNA.R-HSA-5221030XTFAP2 (AP-2) family regulates transcription of other transcription factors.R-HSA-8866906+TRAF6 mediated IRF7 activation.R-HSA-933541,Unfolded Protein Response (UPR).R-HSA-381119Urea cycle.R-HSA-70635.Vitamin D (calciferol) metabolism.R-HSA-1967912rRNA processing in the mitochondrion.R-HSA-88687662tRNA processing in the mitochondrion.R-HSA-6785470:ALKBH2 mediated reversal of alkylation damage.R-HSA-112122;Metabolism of Angiotensinogen to Angiotensins.R-HSA-2022377+NFG and proNGF binds to p75NTR.R-HSA-205017)Receptor Mediated Mitophagy.R-HSA-8934903-Scavenging by Class H Receptors.R-HSA-3000497?Release of apoptotic factors from the mitochondria.R-HSA-1114574Regulation of TLR by endogenous ligand.R-HSA-5686938!Interferon Signaling.R-HSA-913531-Beta-oxidation of pristanoyl-CoA.R-HSA-389887@Binding of TCF-LEF:CTNNB1 to target gene promoters.R-HSA-4411364Carnitine synthesis.R-HSA-71262Fatty acids.R-HSA-211935HDL remodeling.R-HSA-8964058AInhibition of Host mRNA Processing and RNA Silencing.R-HSA-168315+Interleukin-1 family signaling.R-HSA-446652+RUNX3 regulates WNT signaling.R-HSA-8951430$Interleukin-36 pathway.R-HSA-90148264Mitochondrial transcription termination.R-HSA-1633166Nitric oxide stimulates guanylate cyclase.R-HSA-392154PCP-CE pathway.R-HSA-4086400+Plasma lipoprotein remodeling.R-HSA-8963899RET signaling.R-HSA-8853659(Synthesis of Lipoxins (LX).R-HSA-2142700Supplementary Table 4. Gene expression pathway analysis of Seckel syndrome, Nestor-Guillermo progeria and dyskeratosis congenita.Z/ 0)2v365?78- : 5< = >BccW  PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭V~&}"!ᇺ_Ν =r!sh ۴T**~ r׮+JOp'M:kүݭjkh [+wc5(_Zw:Mנ_^F֯A)v[_BJ Pl5 cFZԩnΕ(,cuc;P@$=9K !'> BLra)l)oڣh#CZ&beIĐD7 o߼9{og/^=eVe80_~n&_xw_?zоIwOG,:D?DĒ@!vnu6Y7=B>ı0]hq qޜOM#N\{7Ql9=M f-G8S Ǝ=%IJk 9l,k 4I @ʅH~-tx F]n }L-3CS">i}$CތM\[Ht)#,Ky ? v{"%t#LdM!GQ1w}k׺ O!QL×07c]YfGVvi`> X6I?!aW`=@v hT_"BOwxf(_nڼ UΙJpb/N aZG!jxqÕnAr.:M#߉H|nq7\OVlK:RRlkZha$9릫j}W^eu7=M/3\O//٨iG:3hgL(BO}<ь:g#$.Hxω {!J`4T@UK^vVx:lN:E5L+@2_/uR]ӻLf)낀 c3ĖDug`4 }kaQs/\e^Gn~" 8hGOμNO3b/" tMq]{P> > > > >~  ~ @~ ? ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @  ~ ?~ @  ~ ?~ @    ~ ?~  @    ~ ?~ "@    ~ ?~ $@   ~ ?~ &@   ~ ?~ (@ ~ ?~ *@ ~ ?~ ,@ ~ ?~ .@ ~ ?~ 0@ ~ ?~ 1@ ~ ?~ 2@ ~ ?~ 3@ ~ ?~ 4@ ~ ?~ 5@ ~ ?~ 6@ ~ ?~ 7@ ~ ?~ 8@ ~ ?~ 9@ ~ ?~ :@ ~ ?~ ;@ ~ ?~ <@  ~ ?~ =@ !~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;%;&;';(;);~ >@   "~ ?~ !?@!! !#~ !?~ "@@"" "$~ "?~ #@@## #%~ #?~ $A@$$ $&~ $?~ %A@%% %'~ %?~ &B@&& &(~ &?~ 'B@'' ')~ '?~ (C@(( (*~ (?~ )C@)) )+~ )?\BBBBBBBBB>@F)*  ggD ZO %]hj  dMbP?_*+%;&ffffff?'ffffff?(?)?";333333?333333?&<3U} } } }  -}  %;;;;;;;;; ; ; ; ; ;;;;;;;;;;;;;;;;;;;> > > > >~  ,~ ?~ ? -~ ?~ @ .~ ?~ @ /~ ?~ @ 0~ ?~ @ 1~ ?~ @ 2~ ?~ @ 3~ ?~  @   4~ ?~ "@   5~ ?~ $@   6~ ?~ &@   7~ ?~ (@   8~ ?~ *@ 9~ ?~ ,@ :~ ?~ .@ ;~ ?~ 0@ <~ ?~ 1@ =~ ?~ 2@ >~ ?~ 3@ ?~ ?~ 4@ @~ ?~ 5@ A~ ?~ 6@ B~ ?~ 7@ C~ ?~ 8@ D~ ?~ 9@ E~ ?~ :@ F~ ?~ ;@ G~ ?~ <@ H~ ?~ =@ I~ ?~ >@ J~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;~ ?@   K~ ?~ !@@!! !L~ !?~ "@@"" "M~ "?~ #A@## #N~ #?~ $A@$$ $O~ $?PBBBB>@F$"  ggD Oh+'08@P t KarthikMicrosoft Macintosh Excel@YRM@ɝ4H ՜.+,0HP X`hp x  group_4_overlap_up_pathwaysdown  Worksheets  !"#$%&'()*+,-./012345789:;<=?@ABCDERoot Entry FГ(;OIWorkbookTkSummaryInformation(6DocumentSummaryInformation8>