Research Paper Volume 1, Issue 2 pp 212—218

Figure 1. Types of endogenous DNA double-strand damage marked by γ-H2AX foci. The endogenous DNA double-strand damage that induces H2AX phosphorylation includes both non-telomeric DNA double-stand breaks (DSBs) located at chromatid arms and damaged telomeres. Telomeric damage is a chromosome end-specific damage which includes two types of lesions: 1) DNA double-strand ends which are generally the consequence of telomere dysfunction, though this type of damage can be also present at long telomeres when the telomere loop is open, and 2) DNA DSBs at telomeres.