Multiwalled carbon nanotubes co-delivering sorafenib and epidermal growth factor receptor siRNA enhanced tumor-suppressing effect on liver cancer

Zhili Wen; Yuliang Feng; Youwen Hu; Lingyan Lian; Hongyan Huang; Li Guo; Shanwen Chen; Qian Yang; Moran Zhang; Lijun Wan; Kedong Xu; Degejirifu; Xiaohua Yan

doi:doi:10.18632/aging.103905

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This article has been retracted. Aging (Albany NY). 16:11120-11121 . https://doi.org/10.18632/aging.206013 PMID: 39037871

Research Paper Volume 13, Issue 2 pp 1872—1882

Multiwalled carbon nanotubes co-delivering sorafenib and epidermal growth factor receptor siRNA enhanced tumor-suppressing effect on liver cancer

Figure 4. MWNT/Sor/siRNA inhibited growth of HepG2 cells. (A) The protein expression of epidermal growth factor receptor (EGFR) in HepG2 cells treated with PBS (control), MWNTs, siRNA, Sor, MWNT/Sor, or MWNT/Sor/siRNA by western blotting. (B) Colony number of HepG2 cells in control group, MWNTs, siRNA, Sor, MWNT/Sor, or MWNT/Sor/siRNA detected by colony formation assay. (C) Cell apoptosis rate of HepG2 cells in control group, MWNTs, siRNA, Sor, MWNT/Sor, or MWNT/Sor/siRNA tested by flow cytometry assay. (D) The proteins expression including Bax, Bid, Bim, cleaved caspase-3, and cleaved caspase-9, in HepG2 cells in control group, MWNTs, siRNA, Sor, MWNT/Sor, or MWNT/Sor/siRNA measured by western blot. *P < 0.05.