Research Paper Volume 13, Issue 2 pp 2231—2250

Figure 6. Expression of mature myocardial markers on mRNA level. (A–C) The relative mRNA expression of mature myocardial markers cTnT, cTnI and α-actin on different matrix of 13-16 kPa, 62-68 kPa and control group at the same time point, the 1^st day, the 7^th day, and the 14^th day. On the 7^th day and the 14^th day, the expression of cTnI and α-actin on 13-16 kPa matrix were the highest. The cTnT on 13-16 kPa was expressed the most on the 7^th day, but its expression decreased on the 14^th day. (D, E) The expression of the three mature myocardial markers on the same stiffness at different time points. The expression of cTnI and α-actin increased over time on 13-16 kPa matrix, and the expression of cTnT rose to the highest on the 7^th day but decreased on the 14^th day. On the 62-68 kPa matrix, the expression of α-actin increased over time, while the expression of cTnT and cTnI in the matrix stiffness groups were lower than that of the control group. *P<0.05, **P<0.01, ***P<0.001. n=3.