Research Paper Volume 14, Issue 4 pp 1812—1821
Qi Ling decreases paclitaxel resistance in the human prostate cancer by reversing tumor-associated macrophages function
Figure 1. Qi Ling serum-treated TAMs decreased paclitaxel resistance in prostate cancer cells. (A) Schema for co-culture system of paclitaxel-resistant prostate cancer (DU145-TxR and PC-3-TxR) cells and tumor-associated macrophages (TAMs). (B and C) MTT assay showed viability of DU145-TxR and PC-3-TxR cells harvested from the co-culture system exposed with indicated concentrations of paclitaxel for 24 h. (D) IC50 values of DU145-TxR and PC-3-TxR cells harvested from the co-culture system were determined from the viability versus paclitaxel concentration curves. The data represent the mean ± SD. **p < 0.01; ***p < 0.001, determined by two-way ANOVA followed a post hoc test for panels (B and C), Student’s t-test for panel (D).