Research Paper Volume 15, Issue 16 pp 7933—7955

Figure 1. Identification of the three HCC-specific mTORC1 signaling-related genes. (A) Venn diagram showed that 53 mTORC1-related genes were positively correlated with mTORC1 scores in TCGC-LIHC and ICGC-LIRI-JP cohorts. (B) The 3D plots of PCA of TCGC-LIHC and ICGC-LIRI-JP dataset according to 53 genes’ expression levels in different risk groups. (C) The prognosis was significantly different between the two clusters in TCGC-LIHC and ICGC-LIRI-JP cohorts. (D) The relative alterations in the area under the CDF curves, and tracking plots exhibited the index from 2 to 9 in TCGC-LIHC and ICGC-LIRI-JP cohorts. (E) PAG1, LHFPL2, and FABP5 were identified as critical mTORC1-related genes, regardless of whether the first-order partial correlation is modified.