Research Paper Volume 15, Issue 16 pp 7866—7908
Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging
Figure 4. Enrichment analysis highlights unique signatures with Dectin-1 stimulation across cohorts. Functional enrichment was performed using the Broad institutes Hallmark gene set enrichment analysis. GSEA performed using Hallmark gene sets for each cohort. The dot graph represents the significant Hallmark pathways identified in WGP stimulated Inflammatory monocytes of the respective cohort. The pathways with FDR of <5% were considered significant. For graphical representation, FDR values with 0 were adjusted to 0.00001. The size of the node represents -Log10(FDR) and color of node represent normalized enrichment score. NES = Normalized enrichment scores.