Research Paper Volume 15, Issue 19 pp 10168—10192
Identification and validation of obesity related genes signature based on microenvironment phenotypes in prostate adenocarcinoma
Figure 2. Consistency between ORGs patterns, tumor microenvironment (TME) phenotypes and immunotherapy efficacy. (A) T cell regulated pathways in gene ontology (GO) pathways using GSEA analysis. (B) The location of CNV alteration of ORGs on 43 chromosomes in the PRAD cohort. (C) Different infiltration status of immune cells into TME between two ORGs regulated patterns. Tumor, red; Normal, azure. (D) Box plots of IMmotion150 Myeloid signature, Tumor inflammation signature, JAVELIN and IMmotion150 T-effector (Teff) signature respectively between two ORGs regulated patterns. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. ns, not significant.