Research Paper Volume 15, Issue 20 pp 10856—10874
Deciphering reproductive aging in women using a NOD/SCID mouse model for distinct physiological ovarian phenotypes
Figure 5. Comparison of the reproductive outcomes of NOD/SCID and C57BL/6 mice. (A) The number of metaphase (MII)-oocytes, (B) fragmented oocytes, and (C) 2-cell embryos recovered following controlled ovarian stimulation (COS) in young, Advance maternal age (AMA), and old mice from NOD/SCID and C57BL/6 showed similarities between strains. (D) Blastocyst formation and hatching rates after in vitro embryo culture were affected by age in both mice strains. (E) Summary table presenting aggregate data and mean+ SD per mouse for the number of MII-oocytes, fragmented oocytes, 2-cell embryos and blastocysts in both strains tested. N = 4–6 mice per group. *p < 0.05 AMA and Old vs. Young, #p < 0.05 Old vs. AMA.