Research Paper Volume 15, Issue 19 pp 10524—10539

Figure 4. PRXT treatment suppressed collagen synthesis, inflammation and oxidative stress in bleomycin-induced mice. (A–C) Representative western blotting images of Collagen I and α-SMA and their quantification in murine lung tissues (n=5). (D–F) Relative mRNA expression levels of Tgf-β, Collagen I and α-SMA in murine lung tissues (n=5). (G) SOD activity (n=5). (H) NADPH oxidase activity (n=5). (I) MDA level (n=5). (J–L) Relative mRNA expression levels of Txn-1, Txnrd1, and Gpx4 in murine lung tissues (n=5). *P < 0.05 vs. the Control group, ^#P < 0.05 vs. the PF group. PF, pulmonary fibrosis. PRTX-H, Paroxetine-High dose (7.5 mg·kg⁻¹·day⁻¹).