Research Paper Volume 15, Issue 20 pp 11471—11488
The Wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study
Figure 1. LiCl reverses bone loss in OVX mice. (A) Representative 3D micro-CT images of distal femurs from three groups (Sham surgery groups, OVX groups, OVX+LiCl-treated groups) were performed after eight-week surgery. (B) H&E staining was performed for evaluating the trabecular bone of distal femurs from each group. (C–I) Corresponding parameters showing the treatment of osteoporosis by LiCl therapy. Abbreviations: BV/TV: bone volume/tissue volume; Tb.N: trabecular number; Tb.Sp: trabecular spacing; BMD: bone mass density; Tb.Th: trabecular thickness; BS/BV: bone surface area/bone volume; Tb.PF: trabecular pattern factor. n = 6. All results are performed as mean ± SD. #P < 0.05 vs. control group, *P < 0.05, **P < 0.01 vs. OVX group.