Research Paper Volume 15, Issue 24 pp 14617—14650

Figure 1. The expression levels of TRIMs protein with clinical features in HCC. (A) Differential gene expression in HCC and normal tissues from GSE36411, GSE39791, GSE45267, GSE69715 and GSE87630 (blue: overexpression, red: down expression). (B) Venny diagrams was used to take the intersection three genes (TRIM3, TRIM6 and TRIM28) from above five datasets. (C) We analyzed the expression level of TRIM28 total protein between normal tissue and HCC tissue from TCGA, p < 0.001 (left). Based on the GEPIA 2 data, the TRIM28 expression levels was analyzed by main pathological stages (stage I, stage II, stage III, and stage IV) (right). Log2 (TPM + 1) was applied for log-scale. ^*p < 0.05. (D) Relationship between TRIM28 expression and OS, DSS and PFS by Kaplan-Meier Plotter in HCC from TCGA databases.