Research Paper Volume 15, Issue 24 pp 14617—14650
Integrated analysis and validation of the TRIM28-H2AX-CDK4 diagnostic model assists to predict the progression of HCC
Figure 6. High TRIM28, H2AX, and CDK4 expression is associated with poor prognosis in patients with HCC. (A) An Immunohistochemical analysis of TRIM28, H2AX and CDK4 expression in HCC tissues and adjacent non-tumorous tissues (n = 90). (B) The expression of TRIM28, H2AX and CDK4 in HCC and corresponding adjacent nontumor tissues. ***p < 0.001. (C) The association between the expression of TRIM28, H2AX and CDK4 in HCC patients. (D (a, b)) A Kaplan-Meier analysis of TRIM28, H2AX and CDK4 expression those three genes co-expression for overall survival and PFS in an independent cohort 90 HCC patients. (E (a, b)). The AUC for ROC curve analyses for TRIM28 (AUC = 0.921), H2AX (AUC = 0.795), CDK4 (AUC = 0.890) expression and three gene co-expression (AUC = 0.933) in our independent cohort of HCC.