PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway

Jiacheng Zhong; Chao Yuan; Lin Liu; Yang Du; Yumin Hui; Zhiyuan Chen; Changhui Diao; Rui Yang; Guiyong Liu; Xiuheng Liu

doi:doi:10.18632/aging.205152

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Research Paper Volume 15, Issue 20 pp 11654—11671

PCMT1 regulates the migration, invasion, and apoptosis of prostate cancer through modulating the PI3K/AKT/GSK-3β pathway

Figure 2. PC3 and DU145 cells transfected with siRNA-PCMT1 down-regulated PCMT1 expression and Flag-PCMT1 up-regulated PCMT1 expression. (A, B) siRNA-PCMT1 transfection down-regulated PCMT1 mRNA expression of PC3 and DU145 cells, respectively. (C, D) siRNA-PCMT1 transfection down-regulated PCMT1 protein expression of PC3 and DU145 cells. (E, F) Flag-PCMT1 transfection up-regulated PCMT1 protein expression of PC3 and DU145 cells. Data are presented as mean ± SD of at least three experiments. ^**P < 0.01 and ^***P < 0.001.