Research Paper Volume 16, Issue 2 pp 1182—1191
Myeloid-specific knockout of Notch-1 inhibits MyD88- and TRIF-mediated TLR signaling pathways by regulating oxidative stress-SHP2 axis, thus restraining aneurysm progression
Figure 2. Notch-1-cKO in macrophages inhibited the elastic lamina degradation and macrophages infiltration in AAA. (A) representative image for Masson’s staining, α-SMA staining, CD68 immunostaining, and Verhoeff-van Gieson staining; (B) statistical data for AAA areas, macrophages, smooth muscle cells as well as ratio of aortic dissection. N = 9, *P < 0.05, **P < 0.01, apoE-KO/Notch-1MAC-KO group vs. apoE-KO/Notch-1WT group.