Research Paper Volume 16, Issue 3 pp 2475—2493
KLF3 promotes colorectal cancer growth by activating WNT1
Figure 6. Knockdown of WNT1 attenuates proliferation and invasion in CRC. (A, B) WNT1 mRNA and protein levels in CRC cells following transfection with si-WNT1 or si-NC. (C–K) Alleviation of the malignant phenotype in CRC cells, shown by CCK-8, EdU, wound healing, and invasion assays. Knockdown of WNT reduced nausea in CRC cell lines HCT116 and SW480, as demonstrated by assays mentioned in (C–K). Scale bars: 50 μm, 200μm. *p < 0.05; **p < 0.01.