Research Paper Volume 16, Issue 5 pp 4348—4362

Prenatal diesel exhaust exposure alters hippocampal synaptic plasticity in offspring

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Figure 5. Protein expression of NMDA/PKA/CREB and CPEB3 signaling pathway-associated genes in hippocampus samples of 56 days male offspring mice. (A) Western blot analysis of p-CREB, CREB, PKA, N2A, N2B and NR1 protein in hippocampus. (B) Western blot analysis of CPEB3, NEUN, PSD-95 and SYN protein in hippocampus. (C) Immunohistochemical analysis of NR1, N2B and N2A protein in hippocampus. (ac) Control group (CON). (df) DEPs treatment groups (DEPs, the MD group). (D) Immunohistochemical analysis of SYN, PSD-95 and NEUN protein in hippocampus. (ac) Control group (CON). (df) DEPs treatment groups (DEPs, the MD group). The values shown are the mean ± SD of (NAB=9, NCD=3). Compared to control; * p < 0.05, ** p < 0.01.