Probucol protects against brain damage caused by intra-neural pyroptosis in rats with vascular dementia through inhibition of the Syk/Ros pathway

Jingyi Zhu; Jing Du; Wenhui Kou; Chenling Liu; Jianchun Fan; Ziyan Zhu; Lexiu Deng; Lingling Guan; Yuandi Wang; Aimei Yu

doi:doi:10.18632/aging.205593

← Back

Research Paper Volume 16, Issue 5 pp 4363—4377

Probucol protects against brain damage caused by intra-neural pyroptosis in rats with vascular dementia through inhibition of the Syk/Ros pathway

Figure 6. Probucol reduces oxidative stress and pyroptosis in microglial cells treated with LO/LG. (A) WB assay of p-Syk and oxidative stress markers (gp91^phox, p47^phox, and p22^phox). (B) Statistical data of WB assay results. (C) WB assay of pyroptosis markers (NLRP3, ASC, and Caspase-1). (D) Statistical data of WB assay results. Data are expressed as mean ± SEM. n = 3/group. ^**P < 0.01: LO/LG group vs. Probucol group.