Research Paper Volume 16, Issue 5 pp 4759—4777
Network pharmacology and transcriptomic profiling elucidate the therapeutic effects of Ranunculus ternatus Thunb on liver fibrosis via MK3-NF-κB inhibition
Figure 2. Analysis of the active ingredients of Ranunculus ternatus Thunb and liver fibrosis causative genes through network pharmacology. (A) Genecards, TTD and OMIM databases of disease-related genes, taken as a concatenation. (B) Drug targets and disease targets taken as intersection results. (C) Compound-target network. Red dots represent activities contained in cataplasma. Green rhombus represents targets. (D) Set the minimum required interaction score to 0.4 and draw a PPI network diagram. (E) Target genes were subjected to GO and KEGG analysis, focusing on the apoptotic pathway. (F) DO enrichment for the active ingredient of Ranunculus ternatus Thunb herb, β-sitosterol.