Research Paper Volume 16, Issue 5 pp 4789—4810
SORBS1 inhibits epithelial to mesenchymal transition (EMT) of breast cancer cells by regulating PI3K/AKT signaling and macrophage phenotypic polarization
Figure 4. SORBS1 inhibits MDA-MB-231 and SKBR3 cell invasion and migration. MDA-MB-231 and SKBR3 cells were transfected with SORBS1 overexpression plasmid and siRNA for 48 h. (A) Changes in the migratory ability of MDA-MB-231 and SKBR3 cells were detected by scratch assay. (B) Changes in the invasive ability of MDA-MB-231 and SKBR3 cells were detected by transwell assay (* P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001).