Research Paper Volume 16, Issue 9 pp 7704—7732
Immune cell senescence and exhaustion promote the occurrence of liver metastasis in colorectal cancer by regulating epithelial-mesenchymal transition
Figure 8. Analysis of transcription factor activity. (A) Presentation of a heatmap illustrating variations in transcription factor activity between primary and liver metastasis colorectal cancer tissues. (B) Exploration of the molecular mechanisms by which aging and exhausted immune cells promote CRC progression and metastasis. (C) Detailed annotation of the transcription factor-target regulatory network.