Research Paper Volume 16, Issue 8 pp 7311—7330
EIF3B stabilizes PCNA by counteracting SYVN1-mediated ubiquitination to serve as a promotor in cholangiocarcinoma
Figure 1. EIF3B was abundantly expressed in cholangiocarcinoma tissues and cells. (A) Typical images and quantitative data illustrations of EIF3B immunohistochemical staining in cholangiocarcinoma tissues and para-carcinoma tissues. Scale bar: 50 μm. Magnification times: 200 ×, 400 ×. (B) EIF3B mRNA and protein levels in cholangiocarcinoma cell lines (HCCC-9810, RBE, HUCCT1, QBC939) and HIBEC cell lines. The experiments were in triplicate. (C) Kaplan-Meier survival analysis was performed to reveal the relationship between EIF3B expression and prognosis of cholangiocarcinoma patients. Results were presented as mean ± SD. *** P < 0.001.