ࡱ>  !bjbj 0!33333GGGG[,GlbbbDFFFFFF%F-3bbbbbF33sbv33DbD $G00"3 bbbFFbbbbbbbbbbbbbbbb : Supplemental Table 1: Resveratrol rescues low activity of the flies on high calorie diet The pairwise differences can be summarized as follows: 0.5 50Res0.5 100Res0.5 200Res 0.5 EtOH1.5 50Res1.5 100Res1.5 200Res1.5 EtOH0.5 50Res---********-0.5 100Res -*-*---0.5 200Res-************-0.5 EtOH----**1.5 50Res---***1.5 100Res--*1.5 200Res-***1.5 EtOH-* = p < .05 ** p < .01 *** = p < .001 A Tukey HSD post-hoc test was conducted on the mean 24 hour spontaneous physical activity of male wild type CS flies kept on low food with 50 mM, 100 mM and 200 mM resveratrol (0.5 50Res, 0.5 100Res, 0.5 200Res), 0.5 low calorie food with ethanol, (0.5 EtOH) or high calorie food with 50 mM, 100 mM and 200 mM resveratrol (1.5 50Res, 1.5 100Res, 1.5 200Res) or ethanol (1.5 EtOH) to determine which means are paiwise statistically significantly different from one another. 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O ! 8@0(  B S  ?_gJNVZy##3  #d!#@(!H@H H8@UnknownG* Times New Roman5Symbol3. * Arial?= * Courier New3* TimesA BCambria Math AhԦ&&24d 2q?'Yy2OTable 1: Life span of flies homozygous for the mlenapts mutation is decreased UCHCdmitrievOh+'0D 0 DP p |  PTable 1: Life span of flies homozygous for the mlenapts mutation is decreased UCHCNormal dmitriev7Microsoft Office Word@zT@tM@$@$G|VT$m- . &" WMFC (HlVT$m EMFH \KhC   % %  Rp@Times  pO`2ph TO`2ph jEU1hp \ FU1M  3X'3* TimesT1XhPM1=RK1\ dv% % %  TDX@E@TLSupplemental Table 1: Resveratrol rescues low activity of the flies on high calorie 8878,R,8!2C28,2!H,'2,,3!,2-,',8,'2I2,!2!22"!8,",'28728,22,, Tl<@E@'LXdiet a8,!TT<@E@'LP e 6 Rp@Times New Roman  pO`2ph TO`2ph jEU1hp FU1XG* Times ew RomanhPM1=RK1dv% % % TT?@E@LP oc"!"  T @E@7LThe pairwise differences can be summarized as follows: rt-&!&!5!&!!&!!"!&&!&:9!!!&!&&5TT  @E@ LP nt"!"  TT?@E@.LP su"!" !EY Rp@Times New Roman 8O`280 O`280 jEU108 FU1XG* Times ew RomandPM1=RK1dv% % % TTE@E@LEYP io"!EY" " !^E % % %  TE@E@ L^E`0.5 50Res <"""!-TTE@E@L^EP :r"!^E" " !E % % %  T-EX@E@- LE`0.5 100Res"""!!-TTYEz@E@YLEP n"!E" " !E)  % % %  TlEM@E@LE) X0.5 2"""TpNE @E@NLE) X00Res !!-TT E& @E@ LE) P "!E) " " !. E  % % %  T|x Ew @E@x L. E \0.5 EtOH""(00TTx E @E@x L. E P "!. E " " ! E_  % % %  TT E/ @E@ L E_ P1"T|0 E @E@0 L E_ \.5 50Res""!-TT E: @E@ L E_ P "! E_ " " !c E  % % %  TX E @E@ Lc E P1."T| E @E@ Lc E \5 100Res""!!-TT E @E@ Lc E P "!c E " " ! E % % %  Tl0E@E@0L EX1.5 2"""TlE[@E@L EX00Res!!-TT\E}@E@\L EP "! E" " !E) % % %  T|E@E@LE)\1.5 EtOH""(00TTE@E@LE)P "!E)" " '% LdADA!??%  % LdADA!??%  % LdAXDA!??%  % LdYA\DYA!??%  % Ld]AD]A!??%  % LdADA!??%  % LdADA!??%  % LdADA!??%  % LdA) DA!??%  % Ld* A- D* A!??%  % Ld. A D. A!??%  &" WMFC H% Ld A D A!??%  % Ld A^ D A!??%  % Ld_ Ab D_ A!??%  % Ldc A Dc A!??%  % Ld A D A!??%  % Ld AD A!??%  % LdADA!??%  % LdA(DA!??%  % Ld)A,D)A!??%  % Ld)A,D)A!??%  % LdEEM!??%  % LdYE\YEM!??%  % LdEEM!??%  % LdEEM!??%  % Ld* E- * EM!??%  % Ld E  EM!??%  % Ld_ Eb _ EM!??%  % Ld E  EM!??%  % LdEEM!??%  % Ld)E,)EM!??% !Y % % %  T@E@ LY`0.5 50Res"""!-TT@E@LYP "!Y" " !^ % % %  TT2@E@L^P-TT3T@E@3L^P "!^" " ! % % %  TT@E@LP-TT@E@LP "!" " !)  % % %  TTSh@E@SL) P-TTi@E@iL) P "!) " " !.   % % %  TX  @E@ L.  P**!"TT ; @E@ L.  P "!.  " " ! _  % % %  T`a  @E@a L _ T***!!"TT  @E@ L _ P "! _ " " !c   % % %  TT > @E@ Lc  P*!TT? ` @E@? Lc  P "!c  " " !  % % %  TX@E@L P**!"TT@E@L P "! " " !) % % %  TTRg@E@RL)P-TTh@E@hL)P "!)" " % Ld!??%  % LdX!??%  % LdY\Y!??%  % Ld]]!??%  % Ld!??%  % Ld!??%  % Ld!??%  % Ld) !??%  % Ld* - * !??%  % Ld.  . !??%  % Ld   !??%  % Ld ^  !??%  % Ld_ b _ !??%  % Ldc  c !??% &" WMFC H % Ld   !??%  % Ld  !??%  % Ld!??%  % Ld(!??%  % Ld),)!??%  % LdL!??%  % LdY\YL!??%  % LdL!??%  % LdL!??%  % Ld* - * L!??%  % Ld   L!??%  % Ld_ b _ L!??%  % Ld   L!??%  % LdL!??%  % Ld),)L!??% !Y3 % % %  T*2@E@# LY3d0.5 100Res """!!-TT+L2@E@+#LY3P "!Y3" " !^3 % % %  TT(I2@E@(#L^3P "!^3" " !3 % % %  TT2@E@#L3P-TT2@E@#L3P "!3" " !) 3 % % %  TTNn2@E@N#L) 3P*!TTo2@E@o#L) 3P "!) 3" " !.  3 % % %  TT  2@E@ #L.  3P-TT $ 2@E@ #L.  3P "!.  3" " ! _ 3 % % %  TT  2@E@ #L _ 3P*!TT  2@E@ #L _ 3P "! _ 3" " !c  3 % % %  TT# 8 2@E@# #Lc  3P-TT9 Z 2@E@9 #Lc  3P "!c  3" " ! 3 % % %  TT2@E@#L 3P-TT2@E@#L 3P "! 3" " !)3 % % %  TTRg2@E@R#L)3P-TTh2@E@h#L)3P "!)3" " % Ld!??%  % LdX!??%  % LdY\Y!??%  % Ld]]!??%  % Ld!??%  % Ld!??%  % Ld!??%  % Ld) !??%  % Ld* - * !??%  % Ld.  . !??%  % Ld   !??%  % Ld ^  !??%  % Ld_ b _ !??%  % Ldc  c !??%  % Ld   !??%  % Ld  !??%  % Ld!??%  % Ld(!??%  % Ld),)!??%  % Ld2&" WMFC HM!??%  % LdY\2YM!??%  % Ld2M!??%  % Ld2M!??%  % Ld* - 2* M!??%  % Ld  2 M!??%  % Ld_ b 2_ M!??%  % Ld  2 M!??%  % Ld2M!??%  % Ld),2)M!??% !7Y % % %  Tl7s@E@sL7YX0.5 2"""Tlt7@E@tsL7YX00Res!!-TT7;@E@sL7YP "!7Y" " !^7 % % %  TT(7I@E@(sL^7P "!^7" " !7 % % %  TT7@E@sL7P "!7" " !7)  % % %  TTS7h@E@SsL7) P-TTi7@E@isL7) P "!7) " " !. 7  % % %  T` 7) @E@ sL. 7 T***!!"TT* 7K @E@* sL. 7 P "!. 7 " " ! 7_  % % %  T`a 7 @E@a sL 7_ T***!!"TT 7 @E@ sL 7_ P "! 7_ " " !c 7  % % %  T` 7_ @E@ sLc 7 T***!!"TT` 7 @E@` sLc 7 P "!c 7 " " ! 7 % % %  T`7@E@sL 7T***!!"TT7@E@sL 7P "! 7" " !7) % % %  TTR7g@E@RsL7)P-TTh7@E@hsL7)P "!7)" " % Ld363!??%  % Ld3X63!??%  % LdY3\6Y3!??%  % Ld]36]3!??%  % Ld363!??%  % Ld363!??%  % Ld363!??%  % Ld3) 63!??%  % Ld* 3- 6* 3!??%  % Ld. 3 6. 3!??%  % Ld 3 6 3!??%  % Ld 3^ 6 3!??%  % Ld_ 3b 6_ 3!??%  % Ldc 3 6c 3!??%  % Ld 3 6 3!??%  % Ld 36 3!??%  % Ld363!??%  % Ld3(63!??%  % Ld)3,6)3!??%  % Ld77M!??%  % LdY7\Y7M!??%  % Ld77M!??%  % Ld77M!??%  % Ld* 7- * 7M!??%  % Ld 7  7M!?&" WMFC H?%  % Ld_ 7b _ 7M!??%  % Ld 7  7M!??%  % Ld77M!??%  % Ld)7,)7M!??% !Y % % %  T|@E@LY\0.5 EtOH""(00TT@E@LYP "!Y" " !^ % % %  TT(I@E@(L^P "!^" " ! % % %  TT@E@LP "!" " !)  % % %  TT^@E@^L) P "!) " " !.   % % %  TT  @E@ L.  P-TT $ @E@ L.  P "!.  " " ! _  % % %  TT  @E@ L _ P-TT  @E@ L _ P "! _ " " !c   % % %  TT# 8 @E@# Lc  P-TT9 Z @E@9 Lc  P "!c  " " !  % % %  TT@E@L P-TT@E@L P "! " " !) % % %  TX<~@E@<L)P**!"TT@E@L)P "!)" " % Ld!??%  % LdX!??%  % LdY\Y!??%  % Ld]]!??%  % Ld!??%  % Ld!??%  % Ld!??%  % Ld) !??%  % Ld* - * !??%  % Ld.  . !??%  % Ld   !??%  % Ld ^  !??%  % Ld_ b _ !??%  % Ldc  c !??%  % Ld   !??%  % Ld  !??%  % Ld!??%  % Ld(!??%  % Ld),)!??%  % LdM!??%  % LdY\YM!??%  % LdM!??%  % LdM!??%  % Ld* - * M!??%  % Ld   M!??%  % Ld_ b _ M!??%  % Ld   M!??%  % LdM!??%  % Ld),)M!??% !Y& % % %  TT$@E@LY&P1"T|$@E@LY&\.5 50Res""!-TT$@E@&" WMFC HLY&P "!Y&" " !^& % % %  TT(I$@E@(L^&P "!^&" " !& % % %  TT$@E@L&P "!&" " !) & % % %  TT^$@E@^L) &P "!) &" " !.  & % % %  TT  $@E@ L.  &P "!.  &" " ! _ & % % %  TT  $@E@ L _ &P-TT  $@E@ L _ &P "! _ &" " !c  & % % %  TT# 8 $@E@# Lc  &P-TT9 Z $@E@9 Lc  &P "!c  &" " ! & % % %  TT$@E@L &P-TT$@E@L &P "! &" " !)& % % %  T`+$@E@+L)&T***!!"TT$@E@L)&P "!)&" " % Ld!??%  % LdX!??%  % LdY\Y!??%  % Ld]]!??%  % Ld!??%  % Ld!??%  % Ld!??%  % Ld) !??%  % Ld* - * !??%  % Ld.  . !??%  % Ld   !??%  % Ld ^  !??%  % Ld_ b _ !??%  % Ldc  c !??%  % Ld   !??%  % Ld  !??%  % Ld!??%  % Ld(!??%  % Ld),)!??%  % Ld%M!??%  % LdY\%YM!??%  % Ld%M!??%  % Ld%M!??%  % Ld* - %* M!??%  % Ld  % M!??%  % Ld_ b %_ M!??%  % Ld  % M!??%  % Ld%M!??%  % Ld),%)M!??% !*Yv % % %  TX*u@E@fL*YvP1."T| *u@E@ fL*Yv\5 100Res""!!-TT*;u@E@fL*YvP "!*Yv" " !^*v % % %  TT(*Iu@E@(fL^*vP "!^*v" " !*v % % %  TT*u@E@fL*vP "!*v" " !*) v % % %  TT^*u@E@^fL*) vP "!*) v" " !. * v % % %  TT * u@E@ fL. * vP "!. * v" " &" WMFC hH! *_ v % % %  TT * u@E@ fL *_ vP "! *_ v" " !c * v % % %  TT# *8 u@E@# fLc * vP-TT9 *Z u@E@9 fLc * vP "!c * v" " ! *v % % %  TT*u@E@fL *vP-TT*u@E@fL *vP "! *v" " !*)v % % %  TTM*mu@E@MfL*)vP*!TTn*u@E@nfL*)vP "!*)v" " % Ld&)&!??%  % Ld&X)&!??%  % LdY&\)Y&!??%  % Ld]&)]&!??%  % Ld&)&!??%  % Ld&)&!??%  % Ld&)&!??%  % Ld&) )&!??%  % Ld* &- )* &!??%  % Ld. & ). &!??%  % Ld & ) &!??%  % Ld &^ ) &!??%  % Ld_ &b )_ &!??%  % Ldc & )c &!??%  % Ld & ) &!??%  % Ld &) &!??%  % Ld&)&!??%  % Ld&()&!??%  % Ld)&,))&!??%  % Ld*u*L!??%  % LdY*\uY*L!??%  % Ld*u*L!??%  % Ld*u*L!??%  % Ld* *- u* *L!??%  % Ld * u *L!??%  % Ld_ *b u_ *L!??%  % Ld * u *L!??%  % Ld*u*L!??%  % Ld)*,u)*L!??% !{Y % % %  Tl{s@E@L{YX1.5 2"""Tlt{@E@tL{YX00Res!!-TT{;@E@L{YP "!{Y" " !^{ % % %  TT({I@E@(L^{P "!^{" " !{ % % %  TT{@E@L{P "!{" " !{)  % % %  TT^{@E@^L{) P "!{) " " !. {  % % %  TT { @E@ L. { P "!. { " " ! {_  % % %  TT { @E@ L {_ P "! {_ " " !c {  % % %  TT. {O @E@. Lc { P "!c { " " ! { % % %  TT{@E@L {P-TT{@E@L {P "! {" " !{) % % %  T`+{@E@+L{)T***!!"TT{@E@L{)P "!{)" " &" WMFC HH % Ldvyv!??%  % LdvXyv!??%  % LdYv\yYv!??%  % Ld]vy]v!??%  % Ldvyv!??%  % Ldvyv!??%  % Ldvyv!??%  % Ldv) yv!??%  % Ld* v- y* v!??%  % Ld. v y. v!??%  % Ld v y v!??%  % Ld v^ y v!??%  % Ld_ vb y_ v!??%  % Ldc v yc v!??%  % Ld v y v!??%  % Ld vy v!??%  % Ldvyv!??%  % Ldv(yv!??%  % Ld)v,y)v!??%  % LdzzM!??%  % LdYz\YzM!??%  % LdzzM!??%  % LdzzM!??%  % Ld* z- * zM!??%  % Ld z  zM!??%  % Ld_ zb _ zM!??%  % Ld z  zM!??%  % LdzzM!??%  % Ld)z,)zM!??% !Y % % %  T|@E@LY\1.5 EtOH""(00TT@E@LYP "!Y" " !^ % % %  TT(I@E@(L^P "!^" " ! % % %  TT@E@LP "!" " !)  % % %  TT^@E@^L) P "!) " " !.   % % %  TT  @E@ L.  P "!.  " " ! _  % % %  TT  @E@ L _ P "! _ " " !c   % % %  TT. O @E@. Lc  P "!c  " " !  % % %  TT@E@L P "! " " !) % % %  TTRg@E@RL)P-TTh@E@hL)P "!)" " % Ld!??%  % LdX!??%  % LdY\Y!??%  % Ld]]!??%  % Ld!??%  % Ld!??%  % Ld!??%  % Ld) !??%  % Ld* - * !??&" WMFC (H%  % Ld.  . !??%  % Ld   !??%  % Ld ^  !??%  % Ld_ b _ !??%  % Ldc  c !??%  % Ld   !??%  % Ld  !??%  % Ld!??%  % Ld(!??%  % Ld),)!??%  % LdM!??%  % Ld!??%  % Ld!??%  % LdX!??%  % LdY\YM!??%  % LdY\Y!??%  % Ld]]!??%  % LdM!??%  % Ld!??%  % Ld!??%  % LdM!??%  % Ld!??%  % Ld) !??%  % Ld* - * M!??%  % Ld* - * !??%  % Ld.  . !??%  % Ld   M!??%  % Ld   !??%  % Ld ^  !??%  % Ld_ b _ M!??%  % Ld_ b _ !??%  % Ldc  c !??%  % Ld   M!??%  % Ld   !??%  % Ld  !??%  % LdM!??%  % Ld!??%  % Ld(!??%  % Ld),)M!??%  % Ld),)!??%  % Ld),)!??%  % % %  Tg@E@X Ld* = p < .05!&!&!!TT/g@E@XLP !"  Ti@E@ L`** p < .01!!"&!!TTi@E@LP !"  Tu@E@Lh*** = p < .001!!!&"%"!!TTv@E@vLP !"  Rp@Times  pO`2ph TO`2ph jEU1hp FU1M  3X'3* TimeshQT1XhPM1=RK1dv% % % TT`@E@MLP % Rp@Times New Roman  pO`2ph TO`2ph jEU1hp FU1XG* Times ew RomanhPM1&" WMFC H=RK1 dv% % % Tc@E@LlA Tukey HSD postB9.-)-B3B..$TTc@E@LP-Tc@E@ALhoc test was conducted on the mean 24 hour spontaneous physical a..))#B)$)..-.))....)F)(.....-$.-.(.)..#..-$)((Tc@E@ Ldctivity of )--. % % % T%; @E@& Llmale wild type F))B.-.)Rp@Times New Roman  pO`2ph TO`2ph jEU1hp ,FU1XG* Times ew RomanhPM1=RK1,dv% % % TX&; @E@&& LPCS=.% % % TT; @E@& LP T ; @E@& Lflies kept on low food with ($-)....B.-.B.TX  ; @E@ & LP50..Rp@Symbol pO`2phTO`2ph jEU1hp LFU1X5Symbolm2PM1=RK1Ldv% % % TT  9 @E@ & LP TT D 9 @E@ & LPm4% % % TTE  ; @E@E & LPMRTl M ; @E@ & LX, 100...% % % TTN d 9 @E@N & LP TTe  9 @E@e & LPm4% % % TT  ; @E@ & LPMRTT  ; @E@ & LP Td  ; @E@ & LTand )..Td = ; @E@ & LT200 .-.% % % TT> q 9 @E@> & LPm4% % % Tr !; @E@r & LtM resveratrol (0.5 R)$-))-.. TX= I @E@ LP50..T`J=  @E@J LTRes=)$T= g @E@ L|, 0.5 100Res, 0.5 200Res.....=)#...--=)$Th=  @E@h AL), 0.5 low calorie food with ethanol, (0.5 EtOH) or high calorie ...B()-)...B.(.(....7BB-.-.))-) % % % T g @E@ L`food with ...B.TXh  @E@h LP50.-% % % TT  @E@ LP TT  @E@ LPm4% % % TT _ @E@ LPMRTl`  @E@` LX, 100...% % % TT . @E@ LP TT/ b @E@/ LPm4% % % TTc  @E@c LPMRTT  @E@ LP Td f @E@ LTand )..Tdg  @E@g LT200 ...% % % TT ; @E@ LPm4% % % T<  @E@< LtM resveratrol (1.5 R)$-)(...TX F  @E@ LP50..T`G  @E@G LTRes=)$Tp  @E@ LX, 1.5 ..T d @E@ Lp100Res, 1.5 200Res...=($..-..=)$Tle  @E@e LX) or . T ~ @E@i cLethanol (1.5 EtOH) to determine which means are paiwise statistically significantly different from ).)-...7BB..()F.)B.).F)).$)).(A$)$($)(-$-.))-,.()-.F T| ! @E@ ]Lone another. Flies were kept at 25 C during recording of the spontaneous physical activity. ..)).-.(2($B))-).)..$=...-))-..-.-)$.d&WMFC H-.(.).-$..-$()))--Tp"  @E@" LXFlies 3)$ T FP @E@; Llwere 9 days old.B)).-)-$..TTG oP @E@G; LP ) % % % TTS  @E@ LP %% % ( 666666666666666666666666666666666666 6 66 6  6 66 6  6 66 6  6 66 6  6 66 6 66666666666666666666  ^`."System--@Times--- 2 uT`\Supplemental Table 1: Resveratrol rescues low activity of the flies on high calorie                2 `\diet  2 `\ @Times New Roman--- 2 `\ ,\`'^2 7`\The pairwise differences can be summarized as follows:     2 `\ ,\`' 2 `\ ,\`',x@Times New Roman--- 2 x ,x'',--- 2 0.5 50Res 2  ,'',H--- 2  H0.5 100Res 2 ?H ,H'',I--- 2 QH0.5 2 2 hH00Res  2 H ,I'',--- 2 0.5 EtOH 2  ,'',---  2 12 .5 50Res 2  ,'',^--- 2 "^1.2 +^5 100Res 2 U^ ,^'',_--- 2 g_1.5 2R2 ~_00ResR 2 _ ,_'',--- 2 1.5 EtOH 2  ,''- @ !w-- @ !w-- @ !Ex-- @ !-- @ !E-- @ !-- @ !E-- @ !H-- @ !EH-- @ !-- @ !E-- @ !-- @ !E-- @ !-- @ !E-- @ !^-- @ !D_-- @ !-- @ !E-- @ !-- @ !-- @ ! w-- @ ! -- @ ! -- @ ! H-- @ ! -- @ ! -- @ ! -- @ ! ^-- @ ! -- @ ! -,x--- 2  x0.5 50Res 2 x ,x'',---  2 - 2  ,'',H---  2 #H- 2 'H ,H'',I---  2 iH- 2 mH ,I'',--- 2 ** 2  ,'',--- 2 *** 2  ,'',^---  2 9^* 2 >^ ,^'',_--- 2 {_** 2 _ ,_'',---  2 - 2  ,''- @ !w-- @ !Ex-- @ !-- @ !E-- @ !-- @ !E-- @ !H-- @ !EH-- @ !-- @ !E-- @ !-- @ !E-- @ !-- @ !E-- @ !^-- @ !D_-- @ !-- @ !E-- @ !-- @ ! w-- @ ! -- @ ! -- @ ! H-- @ ! -- @ ! -- @ ! -- @ ! ^-- @ ! -- @ ! -,x--- 2  x0.5 100Res  2 x ,x'',---  2  ,'',H---  2 #H- 2 'H ,H'',I---  2 hH* 2 nH ,I'',---  2 - 2  ,'',---  2 * 2  ,'',^---  2 :^- 2 =^ ,^'',_---  2 _- 2 _ ,_'',---  2 - 2  ,''- @ !w-- @ !Ex-- @ !-- @ !E-- @ !-- @ !E-- @ !H-- @ !EH-- @ !-- @ !E-- @ !-- @ !E-- @ !-- @ !E-- @ !^-- @ !D_-- @ !-- @ !E-- @ !-- @ ! w-- @ ! -- @ ! -- @ ! H-- @ ! -- @ ! -- @ ! -- @ ! ^-- @ ! -- @ ! -,x--- 2 x0.5 2t2 x00Rest 2 x ,x'',---  2  ,'',H---  2 %H ,H'',I---  2 iH- 2 mH ,I'',--- 2 *** 2  ,'',--- 2 *** 2  ,'',^--- 2 3^*** 2 D^ ,^'',_--- 2 x_*** 2 _ ,_'',---  2 - 2  ,''- @ !w-- @ !Ex-- @ !-- @ !E-- @ !-- @ !E-- @ !H-- @ !EH-- @ !-- @ !E-- @ !-- @ !E-- @ !-- @ !E-- @ !^-- @ !D_-- @ !-- @ !E-- @ !-- @ ! w-- @ ! -- @ ! -- @ ! H-- @ ! -- @ ! -- @ ! -- @ ! ^-- @ ! -- @ ! -,x--- 2 x0.5 EtOH 2 x ,x'',---  2  ,'',H---  2 %H ,H'',I---  2 kH ,I'',---  2 - 2  ,'',---  2 - 2  ,'',^---  2 :^- 2 =^ ,^'',_---  2 _- 2 _ ,_'',--- 2 ** 2  ,''- @ !w-- @ !Ex-- @ !-- @ !E-- @ !-- @ !E-- @ !H-- @ !EH-- @ !-- @ !E-- @ !-- @ !E-- @ !-- @ !E-- @ !^-- @ !D_-- @ !-- @ !E-- @ !-- @ ! w-- @ ! -- @ ! -- @ ! H-- @ ! -- @ ! -- @ ! -- @ ! ^-- @ ! -- @ ! -, x---  2 x 12 x .5 50Res 2 x  , x'', ---  2   , '', H---  2 %H  , H'', I---  2 kH  , I'', ---  2   , '', ---  2  - 2   , '', ^---  2 :^ - 2 =^  , ^'', _---  2 _ - 2 _  , _'', --- 2  *** 2   , ''- @ !w-- @ !Ex-- @ !-- @ !E-- @ !-- @ !E-- @ !H-- @ !EH-- @ !-- @ !E-- @ !-- @ !E-- @ !-- @ !E-- @ !^-- @ !D_-- @ !-- @ !E-- @ !-- @ ! w-- @ ! -- @ ! -- @ ! H-- @ ! -- @ ! -- @ ! -- @ ! ^-- @ ! -- @ ! -, x--- 2 x 1.2 x 5 100Res 2 x  , x'', ---  2   , '',H ---  2 % H ,H '', I---  2 kH  , I'', ---  2   , '', ---  2   , '',^ ---  2 : ^- 2 = ^ ,^ '', _---  2 _ - 2 _  , _'', ---  2  * 2   , ''- @ ! w-- @ !E x-- @ ! -- @ !E -- @ ! -- @ !E -- @ ! H-- @ !E H-- @ ! -- @ !E -- @ ! -- @ !E -- @ ! -- @ !E -- @ ! ^-- @ !D _-- @ ! -- @ !E -- @ ! -- @ !  w-- @ ! -- @ !  -- @ ! H-- @ !  -- @ !  -- @ ! -- @ !  ^-- @ ! -- @ !  -,%x--- 2 #x%1.5 2R2 #x%00ResR 2 #x% ,%x'',%---  2 #% ,%'',%H---  2 #%H% ,%H'',%I---  2 #kH% ,%I'',%---  2 #% ,%'',%---  2 #% ,%'',%^---  2 #<^% ,%^'',%_---  2 #_%- 2 #_% ,%_'',%--- 2 #%*** 2 #% ,%''- @ !w-- @ !Ex-- @ !-- @ !E-- @ !-- @ !E-- @ !H-- @ !EH-- @ !-- @ !E-- @ !-- @ !E-- @ !-- @ !E-- @ !^-- @ !D_-- @ !-- @ !E-- @ !-- @ ! w-- @ ! -- @ ! -- @ ! H-- @ ! -- @ ! -- @ ! -- @ ! ^-- @ ! -- @ ! -,3&x--- 2 0x&31.5 EtOH 2 0x&3 ,3&x'',3&---  2 0&3 ,3&'',3H&---  2 0%&H3 ,3H&'',3&I---  2 0kH&3 ,3&I'',3&---  2 0&3 ,3&'',3&---  2 0&3 ,3&'',3^&---  2 0<&^3 ,3^&'',3&_---  2 0_&3 ,3&_'',3&---  2 0&3- 2 0&3 ,3&''- @ !%w-- @ !E%x-- @ !%-- @ !E%-- @ !%-- @ !E%-- @ !%H-- @ !E%H-- @ !%-- @ !E%-- @ !%-- @ !E%-- @ !%-- @ !E%-- @ !%^-- @ !D%_-- @ !%-- @ !E%-- @ !%-- @ ! &w-- @ !3w-- @ !3w-- @ !E3x-- @ ! &-- @ !3-- @ !E3-- @ ! &-- @ !3-- @ !E3-- @ ! &H-- @ !3H-- @ !E3H-- @ ! &-- @ !3-- @ !E3-- @ ! &-- @ !3-- @ !E3-- @ ! &-- @ !3-- @ !E3-- @ ! &^-- @ !3^-- @ !D3_-- @ ! &-- @ !3-- @ !E3-- @ ! &-- @ !3-- @ !3---- 2 > `\* = p < .05 2 >`\ ,\`'2 K `\** p < .01 2 K`\ ,\`' 2 X`\*** = p < .001 2 X`\ ,\`'@Times--- 2 g`\ @Times New Roman---#2 y`\A Tukey HSD post     2 y`\-m2 yA`\hoc test was conducted on the mean 24 hour spontaneous physical a  2 y `\ctivity of ---"2 `\male wild type  @Times New Roman---2 `\CS --- 2 `\ 52 `\flies kept on low food with   2 `\50@Symbol- - - 2 `\  2 `\m--- 2 `\M2 `\, 100t- - - 2 `\  2 `\m --- 2 `\M 2 `\ 2  `\and 2 #`\200 - - - 2 >`\m ---(2 G`\M resveratrol (0.5 2 `\502 `\Res /2 `\, 0.5 100Res, 0.5 200Res  m2 AA`\), 0.5 low calorie food with ethanol, (0.5 EtOH) or high calorie     ---2  `\food with  2 `\50- - - 2 `\  2 `\m --- 2 `\M2 `\, 100t- - - 2 `\  2  `\m --- 2 `\M 2 #`\ 2 '`\and 2 A`\200 - - - 2 \`\m ---(2 e`\M resveratrol (1.5 2 `\502 `\Res 2 `\, 1.5 &2 `\100Res, 1.5 200Res  2 `\) or 2 c`\ethanol (1.5 EtOH) to determine which means are paiwise statistically significantly different from        2 ]`\one another. Flies were kept at 25 C during recording of the spontaneous physical activity.   2 `\Flies #2 `\were 9 days old.  2 `\ --- 2 `\ --\\``\\``\\``[[__[[__[[__[[__[[__[[__ZZ^^ZZ^^ZZ^^ZZ^^ZZ^^ZZ^^YY]]YY]]YY]]YY]]՜.+,0< hp  UCHC PTable 1: Life span of flies homozygous for the mlenapts mutation is decreased Title  !"#$%&'()*,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~     Root Entry FV$Data 1TableWordDocument0SummaryInformation(+tDocumentSummaryInformation8CompObjy  F'Microsoft Office Word 97-2003 Document MSWordDocWord.Document.89q