ࡱ> kn  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijmRoot Entry Fٴ6lWorkbookSummaryInformation(DocumentSummaryInformation8| \p Olga Krasnovard Ba==t78X@"1Arial1Arial1Arial1Arial1Arial1Arial1$Arial1 Arial1.Times New Roman1.Times New Roman1.Times New Roman1ZCalibri1 ZCalibri14ZCalibri1ZCalibri1ZCalibri1ZCalibri1>ZCalibri14ZCalibri1 ZCalibri1<ZCalibri1,8ZCalibri18ZCalibri18ZCalibri1h8ZCambria1ZCalibri1?ZCalibri1 ZCalibri"kr"\ #,##0;"kr"\ \-#,##0#"kr"\ #,##0;[Red]"kr"\ \-#,##0$"kr"\ #,##0.00;"kr"\ \-#,##0.00)$"kr"\ #,##0.00;[Red]"kr"\ \-#,##0.00@*;_ "kr"\ * #,##0_ ;_ "kr"\ * \-#,##0_ ;_ "kr"\ * "-"_ ;_ @_ .))_ * #,##0_ ;_ * \-#,##0_ ;_ * "-"_ ;_ @_ H,C_ "kr"\ * #,##0.00_ ;_ "kr"\ * \-#,##0.00_ ;_ "kr"\ * "-"??_ ;_ @_ 6+1_ * #,##0.00_ ;_ * \-#,##0.00_ ;_ * "-"??_ ;_ @_ ""kr"\ #,##0_);\("kr"\ #,##0\)'""kr"\ #,##0_);[Red]\("kr"\ #,##0\)(#"kr"\ #,##0.00_);\("kr"\ #,##0.00\)-("kr"\ #,##0.00_);[Red]\("kr"\ #,##0.00\)@;_("kr"\ * #,##0_);_("kr"\ * \(#,##0\);_("kr"\ * "-"_);_(@_).)_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)HC_("kr"\ * #,##0.00_);_("kr"\ * \(#,##0.00\);_("kr"\ * "-"??_);_(@_)61_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_)"Yes";"Yes";"No""True";"True";"False""On";"On";"Off"],[$ -2]\ #,##0.00_);[Red]\([$ -2]\ #,##0.00\)                                                                      ff          P  P         `            a>       H+   H    (  " ||FA+}A} 00_)ef[$ -}A} 00_)ef[$ -}A} 00_)ef[$ -}A} 00_)ef[$ -}A} 00_)ef[$ -}A} 00_)ef [$ -}A} 00_)L[$ -}A} 00_)L[$ -}A} 00_)L[$ -}A} 00_)L[$ -}A} 00_)L[$ -}A} 00_)L [$ -}A} 00_)23[$ -}A} 00_)23[$ -}A} 00_)23[$ -}A} 00_)23[$ -}A}  00_)23[$ -}A}! 00_)23 [$ -}A}" 00_)[$ -}A}# 00_)[$ -}A}$ 00_)[$ -}A}% 00_)[$ -}A}& 00_)[$ -}A}' 00_) [$ -}A}( 00_)[$ -}}) }00_)[$ -##0.  }}* 00_)[$ -???##0.??? ??? ???}-}/ 00_)}A}1 a00_)[$ -}A}2 00_)[$ -}A}3 00_)?[$ -}A}4 00_)23[$ -}-}5 00_)}}7 ??v00_)̙[$ -##0.  }A}8 }00_)[$ -}A}9 e00_)[$ -}x}:00_)[$##  }}; ???00_)[$???## ???  ??? ???}-}= 00_)}U}> 00_)[$## }-}? 00_) 20% - Accent1M 20% - Accent1 ef % 20% - Accent2M" 20% - Accent2 ef % 20% - Accent3M& 20% - Accent3 ef % 20% - Accent4M* 20% - Accent4 ef % 20% - Accent5M. 20% - Accent5 ef % 20% - Accent6M2 20% - Accent6  ef % 40% - Accent1M 40% - Accent1 L % 40% - Accent2M# 40% - Accent2 L湸 % 40% - Accent3M' 40% - Accent3 L % 40% - Accent4M+ 40% - Accent4 L % 40% - Accent5M/ 40% - Accent5 L % 40% - Accent6M3 40% - Accent6  Lմ % 60% - Accent1M 60% - Accent1 23 % 60% - Accent2M$ 60% - Accent2 23ٗ % 60% - Accent3M( 60% - Accent3 23֚ % 60% - Accent4M, 60% - Accent4 23 % 60% - Accent5M0 60% - Accent5 23 %! 60% - Accent6M4 60% - Accent6  23 % "Accent1AAccent1 O % #Accent2A!Accent2 PM % $Accent3A%Accent3 Y % %Accent4A)Accent4 d % &Accent5A-Accent5 K % 'Accent6A1Accent6  F %(Bad9Bad  %) Calculation Calculation  }% * Check Cell Check Cell  %????????? ???+ Comma,( Comma [0]-&Currency.. 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Warning Text %XTableStyleMedium9PivotStyleLight16` oABER zWNERBERNERunique for mutant/ Description cell cycle phase cell cycle process DNA replication biopolymer biosynthetic process biopolymer metabolic process DNA metabolic process gene expression cell cycle mRNA processing mitosis RNA processingF nucleobase, nucleoside, nucleotide and nucleic acid metabolic process M phase of mitotic cell cycle Gene_Ontology mRNA metabolic process RNA metabolic process cellular metabolic process primary metabolic process biosynthetic process# macromolecule biosynthetic process mitotic cell cycle M phase biological_process cellular process macromolecule metabolic process metabolic processp-valueAdjusted p-valueGO ID GO ID! regulation of biological process RNA modification biopolymer catabolic process7 modification-dependent macromolecule catabolic process transcription< regulation of transcription from RNA polymerase II promoter localization+ regulation of transcription, DNA-dependent biopolymer modificationT regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process rRNA metabolic process establishment of localization catabolic process macromolecule catabolic process# protein amino acid phosphorylation& establishment of nucleus localization protein localization protein metabolic process' nuclear mRNA splicing, via spliceosome( negative regulation of cellular process chromatin modification: proteasomal ubiquitin-dependent protein catabolic process regulation of metabolic process sister chromatid segregation protein transport, negative regulation of biosynthetic process transport intracellular transport% mitotic sister chromatid segregation) negative regulation of metabolic process; proteolysis involved in cellular protein catabolic process& proteasomal protein catabolic process regulation of transcription# regulation of biosynthetic process chromosome segregation protein catabolic process. regulation of macromolecule metabolic process* negative regulation of biological process macromolecule localization/ cellular component organization and biogenesis) regulation of cellular metabolic process2 negative regulation of cellular metabolic process protein modification process cellular catabolic process RNA splicing tRNA metabolic process proteolysis. ubiquitin-dependent protein catabolic process0 RNA splicing, via transesterification reactionsU RNA splicing, via transesterification reactions with bulged adenosine as nucleophile biological regulation regulation of cell cycle' chromosome organization and biogenesis phosphate metabolic process phosphorus metabolic process) cellular macromolecule catabolic process( establishment of organelle localization# cellular protein metabolic process$ regulation of RNA metabolic process chromatin remodeling) cellular macromolecule metabolic process regulation of gene expression organelle localization cellular localization& establishment of protein localization& establishment of localization in cell# cellular protein catabolic process cell communication nucleus localization& organelle organization and biogenesis; establishment and/or maintenance of chromatin architecture endosome transport regulation of cellular process1 regulation of macromolecule biosynthetic process autophagy phosphorylation vesicle-mediated transport( post-translational protein modification1 modification-dependent protein catabolic process DNA packaging2 positive regulation of cellular metabolic process response to stimulus tRNA catabolic process] positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process response to DNA damage stimulus] negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process cell cycle checkpoint RNA catabolic process response to stress DNA repair- positive regulation of RNA metabolic process gene silencing) positive regulation of metabolic process( positive regulation of cellular process* positive regulation of biological processBERBERNERNERKGene Ontology enriched classes unique to each mutant from Evert et al, 2004@ F FGene Ontology classes enriched in BERNER mutant from Evert et al, 2004; @ CGene Ontology classes enriched in NER mutant from Evert et al, 20048 = CGene Ontology classes enriched in BER mutant from Evert et al, 20048 = BERNER GOBER GONER GOu. //00bi123H4i6:7J8 9. :< ;X <o5>?ccB  IgR  dMbP?_*+%&?'?(?)?MAdobe PDFS 4dXXA4PRIV ''''0P4(FFSMTJAdobe PDF ConverterResolution1200dpiPageSizeLetterPageRegionLeadingEdgeInputSlotOnlyOne0EBDAStandard" dXX??&U} $ @} @} @} m@} $ @,      EEEEE @ @ @ @~ @@ DC< jF?@DkE?~ @@ DC48тa?@ W[?~ @@ D Cw7? @D3@^)Z)$$$ 7ggDqq rYr@Tabell44|1GO ID ?Times New RomanLvZY8H3p^E32 Description? Times New RomanLvZY8H3p^E3(~3p-value7Times New RomanLvZY8H3p^E3|4Adjusted p-value?Times New RomannLvZY8H3p^E3ww|?Times New RomanXTLp2H<2XT|w'wDTableStyleLight1   j2_i\t  dMbP?_*+%&?'?(?)?MAdobe PDFS 4dXXA4PRIV ''''0P4(FFSMTJAdobe PDF ConverterResolution1200dpiPageSizeLetterPageRegionLeadingEdgeInputSlotOnlyOne0EBDAStandard" dXX??&U} $ @} @} $ @} m@} $ @j,      EEEEE @ @ @ @~ @@ DCgma>@u@1O>~ @u@ D C_760?@?~ @"@ D!Cޓ$?@y%$-pv?~ @"@ DCӺ ?@uT5A?~ @`"@ DC_Un;@AJa/<~ @N@ D"C^ -{>}>@>r1'Z?~ @θ@ D# Ca3> @:m‡>~ @ո@ D$ CM]4? @dl?~ @`@ D% C: ? @V ?~ @Ӹ@ D& C\dz^= @++oK>~ @@ D  CUcZwk> @Q>~ @2@ D'CVҫX<@)9=~ @@ D(CI&=@{VA?>~ @c@ DC~F/>@橳?~ @c@ DCmp'<@*@<~ @d@ D)CƼƩ>@*ېD?~ @@@ D*C+,?@Hm~?~ @@ DCղHh?~ @?~ @@ DC_5?~ @?~ @@ D+Cip[?@`5!?~ @@ D,Cx !?@:;%?~ @`q@ DCnSG>@"&>~ @pq@ DC Mni4?@dl?~ @@ DCid>@P?~ @@ DC >@&ÖÓS?~ @D@ D-CIKQU>@oJyR?~ @@ D.Ca+vV/?@G?~ @@ D/C;)>@䉜~/?~ @@ D0CU0*?@^?B X 8@@@@@@@@@@@@@@@@@<<@@@@@@@@@ !"#$%&'()*+,-./0123456789:;<=>?~ @@ D1 C>ڐ\> @a>~ !@`@ !D2!C֋FY?!@-T?~ "@.@ "D3"C aGyl>"@WϲG?~ #@@ #D#Cp6c8?#@g jY?~ $@ @ $D4$C L?$@ݺa?~ %@@ %D5%C|[b#?%@ë$u?~ &@@ &D6&CXhXub>&@<%B>~ '@[@ 'D7'CUf>'@K&3H?~ (@Q@ (D8(C:rA5?(@Y?~ )@@ )D9)Cg?)@Ciq?~ *@`@ *D:*Cp*j!>*@VjP?~ +@@ +D;+Cii>+@go}>~ ,@R@ ,D<,CH2?,@ (/?~ -@`2@ -D=-CCL>-@'K@?~ .@@ .D>.C L?.@ݺa?~ /@ 1@ /D?/C9 0߹=/@[?>~ 0@P@ 0D@0C¾:F?0@!S>U?~ 1@@ 1DA1C։>1@mNq4?~ 2@t@ 2DB2Cɱu?2@Om?~ 3@k@ 3DC3CKN0P?3@|͍?~ 4@@ 4DD4CVP?4@du?~ 5@@@ 5D5Cf}o>5@y~>~ 6@!@ 6DE6CÍ>6@ 1vF$?~ 7@U@ 7DF7CJ=>7@  S?~ 8@@ 8DG8CpF?8@!S>U?~ 9@@ 9DH9C#w,?9@vkF}?~ :@@@ :DI:C !"Y=:@AO 5S=~ ;@@ ;DJ;Cȯb?;@O`?~ <@@ <D <CD(-><@>~ =@@ =D =C{ȅ>=@h0l4g>~ >@@ >DK>C Z|>>@R>~ ?@U@ ?D ?CאY>?@{ t>D l@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_~ @@@ @DL@Cfy>@@zxS?~ A@l@ ADMAC?A@?~ B@@ BDBC:׻>B@zxS?~ C@@ CDCC03r>C@{@A>~ D@o@ DDNDC)>D@?&=?~ E@pw@ EDOEC>&W>E@ 3% >~ F@w@ FDPFCj|΃Q>F@wL,>~ G@@ GDQGCjQHe>G@~Iļ>~ H@ֿ@ HDH@?@?~ I@R@ IDRIC4!` ?I@qya?~ J@׿@ JDJC& YaS9>J@ct>>~ K@ؿ@ KDKCbU d?K@3 8:^?~ L@Y@ LDSLC7˟D>L@X`>~ M@@ MDTMCxӈ6a?M@ip[[x?~ N@@ NDUNC.=?N@4 ?~ O@ @ ODVOC6 r?O@cz(?~ P@9@ PDWPCޒɷ?P@xZ?~ Q@`@ QDXQCa?Q@^?~ R@@ RDYRCOG=R@ r}[`>~ S@¸@ SDZSC<4$$?S@qv?~ T@@ TD[TCyS c?T@^?~ U@q@ UDUCF!ɬޑ?U@Af?~ V@r@ VD\VC 4`?V@YF?~ W@@ WD WCNto=W@Ux}=~ X@7@ XD]XC?X@ 3mJ?~ Y@ 7@ YD^YC!h\>Y@RS?-+?~ Z@@ ZDZ@?@?~ [@@ [D_[Cd֪%>[@+4)h:?~ \@ 8@ \D`\C"n(>\@u>:?~ ]@ @ ]Da]CC%Z(?]@d`y?~ ^@@ ^Db^CN>^@_t??~ _@7@ _Dc_Ca+vV/?_@G?Dd l@@@@@@@@2@@@@@@@@@@@@@@@@@2@@@@`abcdefghi~ `@T@ `Dd`C&L}o=`@˘vۍj>~ a@@ aDeaC䱰8?a@6?~ b@@ bDfbCVe?b@!AL?c?~ c@@ cDgcC3-/>c@X`>~ d@@ dDhdCX2#S?d@`R|?~ e@@ eDieC7tf>e@Efz>~ f@@ fDjfC7Ʃ1|o?f@<ϱ?~ g@@ gDkgCU)?g@fqsz?~ h@T@ hDlhCAm;=h@$VWH >~ i@@y@ iDmiC)>i@?&=?H@@@@@@@@@>@ 7ggDqq rXrii@Tabell33|1GO ID?Times New RomannLvZY8H3p^E32 Description? Times New RomannLvZY8H3p^E3(~3p-value7Times New RomanLvZY8H3p^E3|4Adjusted p-value?Times New RomannLvZY8H3p^E3ww|?Times New RomanXTLp2H<2XT|w'wDTableStyleLight1   j>*(  dMbP?_*+%&?'?(?)?MAdobe PDFS 4dXXA4PRIV ''''0P4(FFSMTJAdobe PDF ConverterResolution1200dpiPageSizeLetterPageRegionLeadingEdgeInputSlotOnlyOne0EBDAStandard" dXX??&U} @} &@} @} m@} $ @} I!@} m@} $ @} '@} m@} @} $ @j  ,                               E EEE @ @ @ @~ @U@ DFC**, ?@Jes?C C~ @@ DGCR>@rtO#?C C~ @@ DHC2r&?@yZy?C C~ @@ DCudb,'>@濐t>C C~ @@@ DIC@CH?@16T?C C~ @@ DnC:`0?@8TBfD?C C~ @@@ Do Cu2P? @x`C? C C~ @@ DJ C3bb? @:]? C C~ @"@ D! CŨk? @Bi? C C~ @"@ D CĊdm? @o^? C C~ @`"@ D CS y> @l=? C C~ @θ@ D#Cmby>>@F* -%?C C~ @s@ DC#Xf[W?@jǜ?C C~ @Ӹ@ D&C j+=@z+}> C~ @@ D C0>@/sA1?C C~ @U@ D Cc7|bDž>@RHKH(?C C~ @@ DLCPj/?@.9(a?C C~ @2@ D'CqQhxc?@[tYL?C C~ @@ D(Cda҈=@\p>C C~ @c@ DCRu>@x=s>C C~ @S@ DpC'?@HȰ7?C C~ @@ DC*-9(?@2=a?C C~ @g@ DqC?@ӫ(0s? C~ @@ DCުPMI?@HȰ7?C C~ @m@ DrCXrGR?@\mO?C C~ @@ DC^.;1?@:]?C C~ @@ DCgs?@"? C~ @@ D+Ca+e?@ M? C~ @>@ DsC l>@qj> CB X8TTTTTTTTTTTTTJTTTTTTTTJTTTJJ ! " # $ % & ' ( ) * + , - . / 0 1 2 3 4 5 6 7 8 9 : ; < = > ? ~ @@ D, C|~? @.4i? C~ !@m@ !Dt!C^g ?!@Jes?! C~ "@`q@ "D"Cq汸1>"@{n98>" C~ #@pq@ #D#CT# /`>#@K#̾#A?# C~ $@@ $DQ$C o !r>$@ *߉>$ C~ %@ֿ@ %D%@?@?% C~ &@׿@ &D&CkT[T?&@nUf?& C~ '@R@ 'DR'Cu >V!?'@t3:v?' C~ (@R@ (Du(C̈]"?(@9L꺦v?( C~ )@ؿ@ )D)C?)@ڬ\m?) C~ *@@ *D*Cl4Om>*@{JB>* C~ +@@ +D+C5~=+@j}>+ C~ ,@Y@ ,DS,C 7>,@՚A)?, C~ -@@ -Dv-CFw;S?-@67',?- C~ .@&@ .Dw.C8d˵?.@ioT?. C~ /@@ /Dx/C|>/@K#̾#A?/ C~ 0@ @ 0DV0C 8*?0@0/>:u?0 C~ 1@`@ 1DX1C^?~ 1@?1 C~ 2@@ 2DY2Cc=2@\p>2 C~ 3@¸@ 3DZ3C >3@9 1#?3 C~ 4@@ 4D[4CNG?~ 4@?4 C~ 5@@ 5D05Cb->x?~ 5@?5 C~ 6@`@ 6D26C%~{%?6@qՆx?6 C~ 7@@ 7Dy7Cɹ,?7@ⱟR$?7 C~ 8@.@ 8D38C%NQ|>8@⋛U?8 C~ 9@q@ 9D9C.\sG?9@9ߡ(?9 C~ :@r@ :D\:C!@?>:@0T689?: C~ ;@@ ;D;CS.{=;@z+}>; C~ <@@ <D5<CYnk><@F* -%?< C~ =@@ =D =Cbt傼/>=@YT>= C~ >@@ >Dz>C M?>@x #a?> C~ ?@Q@ ?D8?CRX>4??@u,n?? CD lJJJJJ<JJJJJJJJJJJFJJFFJJJJJJJJJ@ A B C D E F G H I J K L M N O P Q R S T U V W X Y [ \ ] ^ _ ~ @@@ @D@@?@?@ C~ A@T@ ADdAC W>A@:2>A C~ B@R@ BD{BCu2P?B@x`C?B C~ C@R@ CD<CC@.N)?C@Mn{?C C~ D@@ DDeDC!̅>&?D@yZy?D C~ E@ 1@ ED?EC^C >E@xP>E C~ F@@@ FD|FCD]2LuJ?F@"ڎ?F C~ G@P@ GD@GC$>G@U@-?G C~ H@@ HDhHCf7vF>H@۱I@YT>I C~ J@@ JDAJCM. vT?J@a824r?J C~ K@@ KDiKCDJ>K@Րļ>K C~ L@k@ LDCLCڐ?Y>L@!D?L C~ M@@ MDDMC&i"?M@9L꺦v?M C~ N@@ ND}NC_N?N@`?N C~ O@T@ ODlOCH <3?O@T9-.?O C~ P@@@ PDPC}}@?P@G?P CQ CR CS CT CU CV CW CX CY C[ C\ C] C^ C_ CBX<JJJJJJJ@JJJJJJJJ ` a b c d e f g h i ` Ca Cb Cc Cd Ce Cf Cg Ch Ci C, >@GG 7ggDqq rYrPP@Tabell22|1BERNER?Times New RomannLvZY8H3p^E32 Description? Times New RomannLvZY8H3p^E3(~3p-value7Times New RomanLvZY8H3p^E3|4Adjusted p-value?Times New RomannLvZY8H3p^E3ww|?Times New RomanXTLp2H<2XT|w'wDTableStyleLight1  /9  dMbP?_*+%&?'?(?)?MAdobe PDFS 4PXXA4PRIV ''''0P4(FFSMTJAdobe PDF ConverterResolution1200dpiPageSizeLetterPageRegionLeadingEdgeInputSlotOnlyOne0EBDAStandard" PXX??&U} @} @} I @} @} m @} %@} $ @ NER/,      EEEEEE A A A~ A A AD~ @t@ B~ @pw@ DO~ @@ Dx~ @w@ DPD~ @u@ D ~ @S@ Dp~ @ո@ D$~ @R@ Du~ @@ D1~ @&@ Dw~ @@ DK~ @>@ Ds~ @d@ D) D D~ @@ Dn~ @D@ D-~ @@ Dz~ @@ Dj D~ @@ DU~ @m@ Dt~ @@ DT~ @m@ DrDD~ @@ Db~ @@ D}D~ @@@ D|~ @l@ DM~ @R@ D{~ @o@ DN~ @@@ Do~ @`2@ D=D~ @@ D>~ @g@ Dq~ @@y@ Dm~ @@ Dv~ @t@ DB~ @@ Dy~ @ @ D4D~ @N@ D"~ @@ DQ~ @ @ DaD~ @@ D9~ @@ D/~ @[@ D7~ @@ DkBX"TB8&888888&8&&&888&888&8  !"#$%&'()*+,-.~ @@ Df~ !@`@ !D:~ "@@ "D_~ #@`@ #D%~ $@@@ $D*~ %@7@ %D]~ &@ 7@ &D^~ '@7@ 'Dc~ (@ 8@ (D`~ )@9@ )DW~ *@!@ *DE~ +@@ +D.,D~ -@@ -D;~ .@@ .D6" >@.* 7ggDqq rr..@Tabell11|1BERNER?Times New RomannLvZY8H3p^E3|2 BERNER GO?Times New RomannLvZY8H3p^E3|3BER?Times New RomannLvZY8H3p^E3|4BER GO?Times New RomannLvZY8H3p^E3|5NER?Times New RomannLvZY8H3p^E36NER GO? Times New RomannLvZY8H3p^E3(w2w|8Times New RomanXTLp2H<2XT|?Times New RomanXTLp2H<2XT|w'wDTableStyleLight1  Oh+'0HPl Supporting Table SVyvind Fensgrdyvind Fensgrd@8J~@0ER~@6՜.+,D՜.+,0 PXh px Final BERNERBERNERunique for mutant  WorksheetsL 9A _MarkAsFinal  F&Microsoft Office Excel 2003 WorksheetBiff8Excel.Sheet.89qCompObj r