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Table 2,  Fold Enrichment Bonferroni GO:0042127 regulation of cell proliferation GO:0008285)negative regulation of cell proliferation GO:0051726regulation of cell cycle GO:0010941regulation of cell death GO:0043067#regulation of programmed cell death GO:0007569 cell aging GO:0042981regulation of apoptosis GO:0007568aging GO:00106046positive regulation of macromolecule metabolic process GO:0007049 cell cycle GO:0033554cellular response to stress GO:0009891+positive regulation of biosynthetic process GO:0040008regulation of growth GO:00313284positive regulation of cellular biosynthetic process GO:0006974response to DNA damage stimulus GO:0043066 negative regulation of apoptosis GO:0051173:positive regulation of nitrogen compound metabolic process GO:0043069,negative regulation of programmed cell death GO:0060548!negative regulation of cell death GO:00105579positive regulation of macromolecule biosynthetic process GO:0008284)positive regulation of cell proliferation GO:0045935\positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process GO:00106056negative regulation of macromolecule metabolic process GO:0022402cell cycle process GO:0006357;regulation of transcription from RNA polymerase II promoter GO:0008283cell proliferation GO:0051172:negative regulation of nitrogen compound metabolic process GO:0045449regulation of transcription GO:0010942!positive regulation of cell death GO:0045934\negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process GO:0043065 positive regulation of apoptosis GO:0001558regulation of cell growth GO:0043068,positive regulation of programmed cell death GO:0006259DNA metabolic process GO:0045941$positive regulation of transcription GO:0010628&positive regulation of gene expression GO:0010033response to organic substance GO:0042325regulation of phosphorylation GO:0009890+negative regulation of biosynthetic process GO:0007346 regulation of mitotic cell cycle GO:0051254,positive regulation of RNA metabolic process GO:0019220)regulation of phosphate metabolic process GO:0051174*regulation of phosphorus metabolic process GO:00313274negative regulation of cellular biosynthetic process GO:0051252#regulation of RNA metabolic process GO:0007050cell cycle arrest GO:00105589negative regulation of macromolecule biosynthetic process GO:00458933positive regulation of transcription, DNA-dependent GO:0006355*regulation of transcription, DNA-dependent GO:0051338"regulation of transferase activity GO:0048545$response to steroid hormone stimulus GO:0051052#regulation of DNA metabolic process GO:0010629&negative regulation of gene expression GO:0051276chromosome organization GO:0009628response to abiotic stimulus GO:0048534)hemopoietic or lymphoid organ development GO:0030308"negative regulation of cell growth GO:0043549regulation of kinase activity GO:0045926negative regulation of growth GO:0006468"protein amino acid phosphorylation GO:0051253,negative regulation of RNA metabolic process GO:0016481$negative regulation of transcription GO:0002520immune system development GO:0045792 negative regulation of cell size GO:0030097 hemopoiesis GO:0051094,positive regulation of developmental process GO:0045859%regulation of protein kinase activity GO:0051329 interphase of mitotic cell cycle GO:0008361regulation of cell size GO:00458923negative regulation of transcription, DNA-dependent GO:0051325 interphase GO:0045786!negative regulation of cell cycle GO:0012501programmed cell death GO:0006281 DNA repair GO:0045597+positive regulation of cell differentiation GO:0009725response to hormone stimulus GO:0007242intracellular signaling cascade GO:0016310phosphorylation GO:0008219 cell death GO:0006915 apoptosis GO:0006916anti-apoptosis GO:0022403cell cycle phase GO:0016265death GO:0032535%regulation of cellular component size GO:0051270regulation of cell motion GO:0043627response to estrogen stimulus GO:0009719response to endogenous stimulus GO:0006796phosphate metabolic process GO:0006793phosphorus metabolic process GO:0000075cell cycle checkpoint GO:0009314response to radiation GO:0000122Dnegative regulation of transcription from RNA polymerase II promoter GO:0042770(DNA damage response, signal transduction GO:00000796regulation of cyclin-dependent protein kinase activity GO:0044093)positive regulation of molecular function GO:0000278mitotic cell cycle GO:0045944Dpositive regulation of transcription from RNA polymerase II promoter GO:0010564 regulation of cell cycle process GO:0032844!regulation of homeostatic process GO:0045787!positive regulation of cell cycle GO:0050678+regulation of epithelial cell proliferation GO:00322680regulation of cellular protein metabolic process GO:0006917induction of apoptosis GO:0012502"induction of programmed cell death GO:0051348+negative regulation of transferase activity GO:0043085)positive regulation of catalytic activity GO:0044092)negative regulation of molecular function GO:0051272"positive regulation of cell motion GO:0008629/induction of apoptosis by intracellular signals GO:0051098regulation of binding GO:0045596+negative regulation of cell differentiation GO:0010638-positive regulation of organelle organization GO:0033043$regulation of organelle organization GO:00512470positive regulation of protein metabolic process GO:0051090+regulation of transcription factor activity GO:0031399*regulation of protein modification process GO:0009967*positive regulation of signal transduction GO:0016568chromatin modification GO:0006325chromatin organization GO:00506804negative regulation of epithelial cell proliferation GO:0048145&regulation of fibroblast proliferation GO:0043523regulation of neuron apoptosis GO:0045137-development of primary sexual characteristics GO:00322709positive regulation of cellular protein metabolic process GO:00106081posttranscriptional regulation of gene expression GO:0006275regulation of DNA replication GO:0040012regulation of locomotion GO:0000723telomere maintenance GO:0051053,negative regulation of DNA metabolic process GO:0006350 transcription GO:0030155regulation of cell adhesion GO:0032200telomere organization GO:0048872homeostasis of number of cells GO:00511306positive regulation of cellular component organization GO:0010647)positive regulation of cell communication GO:00465454development of primary female sexual characteristics GO:0046660female sex differentiation GO:0031960#response to corticosteroid stimulus GO:0042592homeostatic process GO:0051101regulation of DNA binding GO:0031647regulation of protein stability GO:0032845*negative regulation of homeostatic process GO:0060249 anatomical structure homeostasis GO:0048608"reproductive structure development GO:0006260DNA replication GO:0033673&negative regulation of kinase activity GO:0030334regulation of cell migration GO:00071670enzyme linked receptor protein signaling pathway GO:0042326&negative regulation of phosphorylation GO:0009411response to UV GO:0008630LDNA damage response, signal transduction resulting in induction of apoptosis GO:0010212response to ionizing radiation GO:0007548sex differentiation GO:0009991"response to extracellular stimulus GO:0001568blood vessel development GO:0051384#response to glucocorticoid stimulus GO:00105633negative regulation of phosphorus metabolic process GO:0000077DNA damage checkpoint GO:00459362negative regulation of phosphate metabolic process GO:0048732gland development GO:0001944vasculature development GO:0043086)negative regulation of catalytic activity< GO:0040017!positive regulation of locomotion GO:0048146/positive regulation of fibroblast proliferation GO:0050670&regulation of lymphocyte proliferation GO:0070663%regulation of leukocyte proliferation GO:0032944,regulation of mononuclear cell proliferation GO:00314013positive regulation of protein modification process GO:0031570DNA integrity checkpoint GO:0048514blood vessel morphogenesis GO:0051781$positive regulation of cell division GO:0031099 regeneration GO:0051347+positive regulation of transferase activity GO:0006469.negative regulation of protein kinase activity GO:0051249#regulation of lymphocyte activation GO:0051789response to protein stimulus GO:0030335%positive regulation of cell migration GO:0051054,positive regulation of DNA metabolic process GO:0031667response to nutrient levels GO:0007004#telomere maintenance via telomerase GO:0046649lymphocyte activation GO:0007093mitotic cell cycle checkpoint GO:0019216%regulation of lipid metabolic process GO:0008406gonad development GO:0008637apoptotic mitochondrial changes GO:0033674&positive regulation of kinase activity GO:0032204"regulation of telomere maintenance GO:0010833-telomere maintenance via telomere lengthening GO:0007243protein kinase cascade GO:0040007growth GO:0000086%G2/M transition of mitotic cell cycle GO:0001836)release of cytochrome c from mitochondria GO:0001302replicative cell aging GO:0070647<protein modification by small protein conjugation or removal GO:0009416response to light stimulus GO:0050863regulation of T cell activation GO:0022602ovulation cycle process GO:0042129"regulation of T cell proliferation GO:0006302double-strand break repair GO:0051302regulation of cell division GO:0043405!regulation of MAP kinase activity GO:0051271"negative regulation of cell motion GO:0000060*protein import into nucleus, translocation GO:0008585female gonad development GO:0002694"regulation of leukocyte activation GO:0042493response to drug GO:0045321leukocyte activation GO:0043406*positive regulation of MAP kinase activity GO:0030217T cell differentiation GO:0042698ovulation cycle GO:0001525 angiogenesis GO:0006310DNA recombination GO:0043524'negative regulation of neuron apoptosis GO:0050864regulation of B cell activation GO:0052547 regulation of peptidase activity GO:0045860.positive regulation of protein kinase activity GO:00019320regulation of protein amino acid phosphorylation GO:0048589developmental growth GO:0006997nucleus organization GO:0050865regulation of cell activation GO:00019349positive regulation of protein amino acid phosphorylation GO:0009611response to wounding GO:0032355response to estradiol stimulus GO:0000737&DNA catabolic process, endonucleolytic GO:0001775cell activation GO:0050671/positive regulation of lymphocyte proliferation GO:0032205+negative regulation of telomere maintenance GO:0003006"reproductive developmental process GO:0070665.positive regulation of leukocyte proliferation GO:00329465positive regulation of mononuclear cell proliferation GO:0000082%G1/S transition of mitotic cell cycle GO:0048584+positive regulation of response to stimulus GO:0001763&morphogenesis of a branching structure GO:0002684,positive regulation of immune system process GO:0008156&negative regulation of DNA replication GO:0045165cell fate commitment GO:0006278RNA-dependent DNA replication GO:0031575G1/S transition checkpoint GO:0007584response to nutrient GO:0006979response to oxidative stress GO:0042327&positive regulation of phosphorylation GO:0051251,positive regulation of lymphocyte activation GO:0030856-regulation of epithelial cell differentiation GO:0032504#multicellular organism reproduction GO:00486090reproductive process in a multicellular organism GO:00510914positive regulation of transcription factor activity GO:0070661leukocyte proliferation GO:0032943mononuclear cell proliferation GO:0043281regulation of caspase activity GO:0034097response to cytokine stimulus GO:0014070$response to organic cyclic substance GO:0035295tube development GO:0033044%regulation of chromosome organization GO:00459372positive regulation of phosphate metabolic process GO:00105623positive regulation of phosphorus metabolic process GO:0009968*negative regulation of signal transduction GO:0002697%regulation of immune effector processGo Term GO Accession CS genes (%)P-valueKSupplementary Table 2. 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