ࡱ>  PRCDEFGHIJKLMNO)`E bjbj.{{Ebbbbbbbv~~~~Tv0=u <<<<<<<$?hhA<buu<bb<bb<<bb ׆5\~<=00=AAAb!d$<< 0=vvvtZy$cvvvZyvvvbbbbbb Supplementary material Genomes of Strongylocentrotus franciscanus and Lytechinus variegatus: are there any genomic explanations for the two order of magnitude difference in the lifespan of sea urchins? Petr V. Sergiev1, Artem A. Artemov2,3, Egor B. Prokhortchouk3, Olga A. Dontsova1, and Grigory V. Berezkin4 1Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow 119992, Russia 2Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow 119992, Russia 3Center Bioengineering, Russian Academy of Sciences, Moscow, 117312 Russia and National Research Center, Kurchatov Institute, Moscow 123098 Russia 4ESN Group, 123100, Moscow, Russia Alignments of longevity related proteins from long and short living organisms Aligned line SIG, where + indicate positions whose identity vary is consort with longevity is shown where such positions were detected AKT >H sapiens ----------------------MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGY KERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREE WTTAIQTVADGLKKQEEEEMDFRSGSPS-DNSGAEEMEVSLAK-PKHRVTMNEFEYLKLL GKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL-TENRVLQNSRHPFLTALKY SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL GVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGG SEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQ- DDSMECVDSERRPHFPQFSYSASGTA--- >H glaber ----------------------MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGY KERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREE WTTAIQTVADGLKRQEEELMEFQSGSPS-DNSGAEEMEVSLAK-PKHRVTMNEFEYLKLL GKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL-TENRVLQNSRHPFLTALKY SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL GVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGG SEDAKEIMQHRFFASIMWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQ- DDNMECVDSERRPHFPQFSYSASGTA--- >M brandtii -------------------------------------GEYIKNWRPRYFILKTDGSFIGY KEKPQDVDL-PYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREE WTEAIQAVADRLQRQEEERMSCCSPTSQIDNIGEEEMDASATH-HKRK-TMNDFDYLKLL GKGTFGKVILVREKASGKYYAMKILKKEVIIAKDEVAHTL-TESRVLKNTRHPFLTSLKY SFQTKDRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHS-GKIVYRDL KLENLMLDKDGHIKITDFGLCKEGITDTATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL GVVMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGG PDDSKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPEKY DED--GMDNESRPHFPQFSYSASGRE--- >S franciscanus --------------MTTTMSVAEAPLTVIKEGWVQKRGEIAKITQKQLL-------FVFF CLWP---------------AECQILKTEKPAPNTFKVRCLQWTTIIERTFSVSSADERER KPSTHPTILTVLIKLACIRH---------IHIIAHYHHYAPYFIYPSLMTLDDFQLLKCL GKGHFGKVIQVREKKTGELFAIKYLKKAVIVQKEAVRNVL-REQEILQALEHPFLVSLKY SFQTADKLYFVMEYVNGGELFFHLQREKKFSEERARFYAAEIASALEYLHT-HDVIYRDL KAENILLDCDGHVKLADFGLCKEGIAAGDTTSTFCGTPEYIAPEIIQEKPYGKAVDWWAL GVLLYEMLVGTPPFYGESIFQLFSLILHDAISFPRWLSKEAHSILSALLKKHPKARLGSG PEDAQKIKKHQFFRHIKWERLAARQIQPPFVPQVASETDTRYFDQEFTLEPVRLTPPGSG ADTLTATLHEEQSQFEKFSYTDDVPLQK- >S purpuratus --------------MTTTMSVSEAPITVIKEGWVQKRGEYIKNWRPRYFQLKSNGDFVGY KDKPKGKSGDSDALNNFTVAQCQILKTEKPAPNTFKVRCLQWTSFIERTFSVASNDERES WVKALQGVTDSLTRQEREKENQEANA---ANGGKEDSNSAANEASKHKVTMDDFELLKCL GKGTFGKVIQVREKKTGELFAIKVLKKEVIVQKDEVAHTL-TENRVLQKTSHPFLTSLKY SFQTSDRLCFVMEYVNGGELFFHLSRERIFTEERTRFYGAEIVSALSYLHA-QDVIYRDL KLENLLVDEEGHIKITDFGLCKENISYGDMTKTFCGTPEYLAPEILEDNDYGRAVDWWGT GVVMYEMMCGRLPFYSRDHEVLFDLILTENVKFPTRLSNEAKSLLSGLLEKNPKKRLGCG PDDAKEIMRHPFFATINWEDLYERKVRPPFLPKVENETDTRYFDQEFTLEPVRLTPPAAG KDTLTATQHDEQSQFEKFSYTDDVPLQK- >L variegatus SILKCIRARQFAHKSQNISACSAVCFSIIAPAIYQQSIAHIISIQEQCI-------IAGY QSYSI--------FANLSIAECQILKTEKPAPNTFKVRCFQWTTLIERTFSVSSSEERES WVKALQGVADALHKQEQEQNQLAKNE---ANGGKNDSNSTVDDASKLKMTMEDFRLLKCL GKGTFGKVILTRYKKTGKYYAIKVLKKADIVKKDEVAHVL-REQAILQAISHPFLFSLHW THQTDTFLYMLLEYACGGELFYHLSQSARFSEERSKFYAAEIISALDYLHK-QNIIYRDL KPENILLDEEGHIKIADFGLCKEGIGYGDKTSTFCGTPEYIAPEIILNKGYGLSVDWWSL GVLLYEMLTGKPPFYGEDEDQLFDLILHDSPHYPRWLSKDAHSILKALLEKHPGKRLGCG PKDAQEIREHQFFRSIDWEKLYERQIQPPFLPQVAHETDTRYFDQEFTLEPAKLTPPGAG ELTL-CIVTGKGSELDLSLLDDFFCLECL >M musculus ----------------------MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGY KERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREE WATAIQTVADGLKRQEEETMDFRSGSPS-DNSGAEEMEVSLAK-PKHRVTMNEFEYLKLL GKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTL-TENRVLQNSRHPFLTALKY SFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDL KLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGL GVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGG SEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQ- DDSMECVDSERRPHFPQFSYSASGTA--- APOA >H sapiens --------------------------MEHKEVVLLLLLFLKSAAPEQSHVVQDCYHGDGQ SYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLIMNYCRNPDAVAAPYCYTRDPG VRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTY STTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYC NLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTG RTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCS DAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAW SSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTA VAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPH SHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTV TPVPSLEAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTP EYYPNAGLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSL EAPSEQAPTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNA GLIMNYCRNPDAVAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQ APTEQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGL-IMN YCRNPDPVAAPYCYTRDPSVRWEYCNLTQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQ RPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIKNYCRNPD PVAAPWCYTTDPSVRWEYCNL----TRCSDAEWTAFVPPNVILAPSLEAFFEQALTEETP GVQDCYY-HYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGL-TRNYCRNPD AEIRPWCYTMDPSVRWEYCNLTQCLVTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQD CYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPW CYTMDPNVRWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYRGSFS TTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCN LTQCPVMESTLLTTPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTTITGR TCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYCNLTRCPV TESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWS SMIPHWHQRTPENYPNAGL-TENYCRNPDSGKQPWCYTTDPCVRWEYCNL----TQCSET ESGVLETPTVVPVPSMEAHSEAAPTEQTPVVRQCYH-GNGQSYRGTFSTTVTGRTCQSWS SMTPHRHQRTPENYPNDGL-TMNYCRNPDADTGPWCFTMDPSIRWEYCNL----TRCS-- ---------DTEGTVV----APPTVIQVPSLGP-------------------PSE----- -----------------------QDCMFGNGKGYRGKKATTVTG---------------- ----TPCQEWAAQEPHRHSTFIPGTNK--WAGLEKNYCRNPDGDI--------------- ---NGP---------WCYTMNPRK----------------------------LFDYCDIP LCAS-SSFDCGK------PQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTR---------- -FG-KHFC--GGTLISPEWVLTAAHCLKKSSRPSSYKVILGAHQE--------------- ----------VNLESHVQEIEVSRLFLEPTQADIALLKLSRPAVITDKVMPACLPSPDYM VTA-------------------------------------------------RTECYITG W-----------------------GETQGTFGTGLLKEAQLLV----IENEVCNHYKY-- -------ICAEHLARGTDSCQGDSGG--PLVCFEKDKYILQ------GVTS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------WGL GCAR-----------------------------P------------------------NK PGVYARVSRFVTWIEGMMRNN------------------- >H_glaber MSLISCKSIISQDWDTVFQTLPGSPAMDHKEVILLFLLFLKS------------------ ------------------------------------------------------------ --------------------------------------------------GQGIS----- ------------------------------------------------------------ -QDDYENTRGASLVSLTKKQLGA-------------ANIDEC------------------ -------------------------------------------------------AAKCE EE--------------------------------------------------TEFVCRSF Q----------------------------------------------------------- ------------------------------YHSKEE------------------------ ---------------------------------------------QC------------- ------------------------------------------------------------ -------VIM----AENSKSSPIIRMRD-------------------------------- ------------------------------------------------------------ --VILF------------------------------------------------------ ---EKKVYLLECRTGNGKNYRGTMSRTKSGVTCQKWGATFPHRPNYSPGTHPAEGL-ENN YCRNPD------------------------NDPEG------------------------- ------------------------------------------------------------ ----PWCYTTNPDKRYDFCDI----PECED------------------------------ ---ECMH-CLGENYMGKISTTVSGLECQAWDSQVPHAHGFIPSKHPNKNL-KMNYCRNPD GELRPWCFTTDPNKRWEFCNISRC------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------TTP---------------PPPPGPVYQ-CLKGRGENYRGKVAVTVSGRTCQRWS EQTPHKHNRTPENYLCKDL-EENYCRNPDRETAPWCYTTDSKVRWEYCAI----PSCESS Q-----------LSAEHSDGPALP-EQTPVVQECYH-GNGQSYRGTSSITVTGKKCQSWS SVRPHVHGKTPENYPNAGL-TMNYCRNPDVDKSPWCYTTDPSVRWEYCNL----KKCS-- ---------ETEGSVV----ESQTTAQVPSVQA-------------------TSE----- -----------------------PDCMVGYGKEYRGKMATTVAG---------------- ----IPCQGWADQEPHKHRIFTPESNP--QAGLEENYCRNPDGDF--------------- ---SGP---------WCYTMSPTK----------------------------LYDYCDVP QCAP-SSYDCGK------PRVEPKKCPGRVVGGCVANPHSWPWQVSLRTR---------- -FELRHFC--GGTLIAPEWVLTAAHCLEKSLNPAFYKVILGAHQE--------------- ----------INLESNVQRKDVTKLFLEPHRADIALLKLSSPAVITDKIIPACLPSSNYM VAD-------------------------------------------------RTLCYITG W-----------------------GETKGTYGAGLLKEAQLPV----IENKVCNRFEYLN GRVKPTELCAGHLAGGTDSCQGDSGG--PLVCFEKDKYILQ------GVTS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------WGL GCAR-----------------------------P------------------------NK PGVYVRVSTFVKWIEEIMGTN------------------- >M_brandtii --------------------------MGRQELLLLLLLFLRP------------------ ------------------------------------------------------------ --------------------------------------------------GHGDP----- ------------------------------------------------------------ -LDSYVNTQGASLITLTRKELPA-------------GSIAEC------------------ -------------------------------------------------------AAKCE EE--------------------------------------------------TTFTCRSF Q----------------------------------------------------------- ------------------------------YHSKEQ------------------------ ---------------------------------------------HC------------- ------------------------------------------------------------ -------VVM----GDNSKSAPVLRMRD-------------------------------- ------------------------------------------------------------ --VVLY------------------------------------------------------ ---EKRIYLSECKTGNGRRYRGTVSKTKNGVACQKWSDHSPHIPRFSPTSHPLEGL-EEN YCRNPD------------------------NDEKG------------------------- ------------------------------------------------------------ ----PWCYTTDPATRFDYCTI----PECEE------------------------------ ---ECMH-CSGENYEGTISRTKSGLECQAWDSQTPHAHGYIPAKFPSKNL-KMNYCRNPD GEPSPWCFTTNPNKRWELCDIPRC------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------TTP---------------PPSSGPTHQ-CLKGRGESYVGKVAVTLSGHTCQRWS EQTPHKHNRTPENFPCKNL-EENYCRNPDGESAPWCFTTNSKVRWEHCKI----PSCESS Q-----------LSPEQAEATVPP-EQTPVVQECYH-GNGQSYRGTSSTTITGRKCQSWS SMTPHRHSKTPDQIPNAGL-TMNYCRNPDGDKGPWCYTTDPSVRWEFCNL----KKCS-- ---------ETQGAVMNTPPEVPPVS--PQGSS-------------------EAEAGPDI GEPAAAALVPHPRSTEPDLRPLPADCMLGNGKGYRGKKATTVAG---------------- ----TACQAWAAQEPHRHSIFTPETNP--RAGLEKNYCRNPDGDV--------------- ---NGP---------WCYTTDPKK----------------------------LFDYCDVP QCAS-SSFDCGK------PKVEPKKCPGRVVGGCVANPHSWPWQVSLRTR---------- -FR-MHFC--GGTLLSPDWVLTAAHCLERSSRPSSYKVILGAHHE--------------- ----------QNLEADVQERDVSKLVLEPTRADIALLKLSSPAIITDKVIPACLPSADYV VAD-------------------------------------------------RTVCYITG W-----------------------GETQGTFGAGLLKEAQLPV----IENKVCNRYEYLN GRVKSTELCAGLLAGGADSCQGDSGG--PLVCFEKDKYILQ------GVTS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------WGL GCAR-----------------------------P------------------------NK PGVYVRVSRFVKWIEETMKNN------------------- >S franciscanus --------------------------RAQETYLIL------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------DSLVLPTV------------------------------------------ -------------------------------------------------------PNECK LD---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PTGVNYRGNLSQTLSGRECQSWTSQYPHEHSRTPSNYPDAGLGDHN YCRNPD------------------------GEFTA------------------------- ------------------------------------------------------------ -----WCYTTDPSVRWEYCAIGDPSPECSSA----------------------------- ---YCYNDPYGTIYRGELSQTRSGKECQSWTSQSPHEHSRTPSNYPDAGLGDHNYCRNPD GEFTAWCYTTDPDVRWEYCAIG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------DPSEECTDD----PTGTIYRGELSQTLSGKTCQSWT SQYPHEHSRTPSNYPDAGLGDHNYCRNPDGEFTAWCYTTDPDVRWEYCAIGDFSPECTSK Y--------------------------------CYDDPKGTIYRGELSQTLSGKECQSWT SQSPHEHSRTPSNYPDAGLGDHNYCRNPDGEFTAWCYTTDPDVRWEYCAIGLPQEECTVG HLDVTKYLISQGAEVNRGDNDGRTALHIAALKGHLDVTKYLISQGA------EVNKGDND GRTALHLAAQEGH--LDISKKAGQEGRVLETTDGHGSVKVKVRGQTLKYHPAALILLQGA EVNKGDNDGWTALHSAAFNGHLDVTKYLISQGAEVNKGDNDGWTALHIAAQNGHLDVTKY LISQGAEVNKGDNDGRTALHSAAQEGHLDVTKYLISQGAE-------VEMVDNHDQTPLI AAAQNGHLDVTKYLISQGAEVNKGDNDGRTALHSAAQNGHLDVTKYLISQGAEVNKGDND GRTALHSAAQNGHLDVTKYLISQGAEVNKGDNDGRTALHLAAQNGHLDVVKYLISQGAEV NKGDNDGRTPLHLALQLGYQSIADLFIDHSSADLRLRNNDAFPPLHYAAKKNCLEMVKLL VAKDPSLATIEKAHRYTPLHVAAINNHVDIVRVLIELPNCDL-TTIKASQGHSTPLHLAT WEGYTEVIELLVSHGAEVNVKDKDGDTMLHLTIKRRVSGKKFVEDTPTLQKVCKEIGDPA ITTPRDAIIAFFIRHGSDVTIKNNNGHTPFDLLDDERVLLNALMRVAGITP-DELSESLM ECCTPIR----LRYQSFIYKNSHHTPSSFATDADFEGVHRISPDELNLGETVGRGGFGEV KKAVWRGTTVAVKIISTAGSKKAEIEKEVSIHKRARHPNIVSLMAVGHRIGQALIVMEFI DGMDLYDVIFRKK-----VFYENRRKISGKESKERKIPQKDEPHQVRIIFGNISGIPQVE RASRRAYLCDLGLAHIKTRSSMSLSTSVGGPRGTITHMPPEMVQKEGKAWAGPGNDIWSI ACTFLELFVEQRLWEGVEFMALLRMMLKPAAVPP--ILKKVKPEVRTILKPCFEKEPLKR PSAEVLLEQFQKLQQSSK---------------------- >S_purpuratus -------------------------------MAQLFLYMALA------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------ATFVLVSS------------------------------------------ -------------------------------------------------------QSDCT DD---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PNGTIYRGELAQTFSGKTCQSWNSQNPQRHSRTPGNYPDAGLGDHN YCRNPD------------------------SAFTA------------------------- ------------------------------------------------------------ -----WCYTTDPDTRWEYCTIGDFSQECTNP----------------------------- ---ECYHQSPGADYRGEVSTTRNGRECQNWTSQSPHGHSRTPENYPTSGLGDHNLCRNPD GEDFAWCYTTDPSVRWEFCNIG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------LPEKNCTDD----PNGTIYRGELAQTFSGKTCQSWN SQTPQGHSRTPANYPNAGLGDHNYCRNPDGAFTAWCYTTDPDTRWEYCTIGDFSPECTNP E--------------------------------CYHQSPGADYRGEVSTTRNGRECQNWT SQSPHGHSRTPDNYPTSGLGDHNLCRNPDGEEFAWCYTTDPSVRWEFCNIGLPEEVLAL- FQRVREFPPSGFGEEEGGEPDGYPCCTIDHHGEGAPVVDFKAGDRV------RIS-ANID MVKDLHRKNEERNDAIELSKKAGQEGRVLESTDGHGSVKVKVKGQTLKYHPAALILLPKR D---GDDEEEEEEEEEKVEDKKEEKEKEEKVEVKKDKEEKEDGEKRHDDKKKKSDEEYEN IITNAPQVGSK----PVPIPVPAGPADKDVMHRLVEKMTEQLKDAGVSELVTTSEEKQMV KAVAAGNLEKVKDFLRQNPKLANASHSSRSALQVACHEGSLPIVQLLVDAHASLEHKDGD GDTALTFAVIGNNPSVAEFLMERKAYVNTSNKRRRTPMHISAHKDHKSCVEALIKHGGSV NMQDNDGNLPIHLAIKQKSTSLGALFIDHPSADLRLRNNDAFPPLHYAAKRNCLEMVKLL VAKDPSLATIEKDDRYTPLHVAAINNHIDIVRVLIELPNCDL-TTINAGHGHSTPLHLAT WQGYTEVIELLVSHRAEVNVKDKDGDTMLHLTVKRRVSGKKFVHDTPTLQKVCKEIGDPA ITTPRDAIIAYFIRHGSDVTIKNNNGHTPFNLLENEPVLLNALMRVAGITPINEIPIAAD EAVDKTRKEEKKKDKEERSPSAEKAPKPEKKQADFEGVHRISPEELKLGKTIGQGGFGEV KKAVWRGTTVAVKIISTAGSKEDEVEKEVSIHKRARHPNIVSLMAVGHRIGQVLIVMEFI DGMDLHDVIFRKKKDGITLTPELKMSITVGLLSALTFLHASKILHLDIKPSNV----MVE RASRRAYLCDLGLAHIKTRSSMSLSTSMGGPRGTITHMPPEMVQREGKAWAGPGNDIWSI ACTFLELFVEQRLWEGAEFMVLLRTLLKPASVPP--ILKKVKTEVRTILKPCFDKEPLKR PSAEVLLEQFQKLQQSSP---------------------- >L variegatus --------------------------------LQFFSIFLTK------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------FKFFTFAE------------------------------------------ -------------------------------------------------------THTCE LD---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------PSGTNYRGYLSTTRSGKTCQSWTSQTPHGHSRTPDNYPDAGLGNHN YCRNPD------------------------REFTA------------------------- ------------------------------------------------------------ -----WCYTTDPEVRWEYCAIGDLDPECTDP----------------------------- ---ECYKDPSGTDYRGNVSTTRSGKTCQAWTSQTPHGHSRTPDNYPDAGLGNHNYCRNPD REFTAWCYTTDPDTRWEYCNIG-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------LPDPECTED----PSGTDYRGYVSTTRSGKTCQAWT SQTPHGHSRTPDNYPDAGLGNHNYCRNPDREFTAWCYTTDPDTRWEYCNIGDLSPECTDP E--------------------------------CYKDPSGTDYRGNVSTTRSGKTCQAWT SQTPHGHSRTPDNYPDAGLGNHNYCRNPDREFTAWCYTTDPDTRWEYCNIGLPQSDCA-- -----DFLLQGGSHIFFFKLE--ICCS--NLRERTAISTFLISKSVGLKLFLKAKIEKKK GKKPLLAAAQRLH--IDLPIILISQGAEVNKRNFTGWTALHSAAFIGHLDVNKYLISQGA EINRGETDGWTALHFAAKNGHLDITQYLISQGAQVNRGNITGSTALHIAAENGHLDVTKY LISQGAEVNKGDNDGWTALHSAAENGHLDVIKYLISQGAD-------VNKGDNDGWTALH RAAENGHLDVTKYLISQGAEVNKGDNDGWTALHIAAQNGHLDVVKYLISQGAEVNKGDND GWTALHIAAENGHLDVTKYLISQGAEVNKGDNDGWTALHIAAQNGHLDVTKYLISQGAEV NKGDNDGWTALHIAIKNGHLDVVKYLISQGAAALKASTASGETALHYAAKRNCLRVVKLM VAKDPSLALIEKDDGYTPLHVAAINNHLEISRVLINLL-CKIPATIDAGEGHSTPLHLAT WQGYSELVELLVSHGAAINLKDKDGDTVLHLSIRRRKSGQKFVQDTPIKSSVCKEVKETA ITTPRDALIAYFIQHGSDVTIKNKNGHTPFELLDEEPLLLNALMRVAGIKP-DKVIIAQC MIVIALH-QMHCKAQSHCYNQIYSIPQAISIPSDFEGVHIIQVCDLDMGRMVGKGQFGVV HHASWRGTTVAVKKISIAGSRKEEVEKEVAIHRRARHPNIVSLMAVGHRIGQALIVMEFI DGMDLNDVIFKKKKDGITLTKELKMSTTLGLLSALTYLHASKILHLDIKPSNV-MVSSIY LHAAKGILYEYILSVLYQ-----------------IYISPQFI-------PSPCSHSSHI ILQHYQLI-------GTLHKIISTISYQSHGIWPKSILSTI-SHMSYIINQC----TLDK SISSHHIIQFGLLSMSSHGINFGPLSGHLHMGINLVYYQV >M_musculus --------------------------MDHKEVILLFLLLLKP------------------ ------------------------------------------------------------ --------------------------------------------------GQGDS----- ------------------------------------------------------------ -LDGYISTQGASLFSLTKKQLAA-------------GGVSDC------------------ -------------------------------------------------------LAKCE GE--------------------------------------------------TDFVCRSF Q----------------------------------------------------------- ------------------------------YHSKEQ------------------------ ---------------------------------------------QC------------- ------------------------------------------------------------ -------VIM----AENSKTSSIIRMRD-------------------------------- ------------------------------------------------------------ --VILF------------------------------------------------------ ---EKRVYLSECKTGIGNGYRGTMSRTKSGVACQKWGATFPHVPNYSPSTHPNEGL-EEN YCRNPD------------------------NDEQG------------------------- ------------------------------------------------------------ ----PWCYTTDPDKRYDYCNI----PECEE------------------------------ ---ECMY-CSGEKYEGKISKTMSGLDCQAWDSQSPHAHGYIPAKFPSKNL-KMNYCRNPD GEPRPWCFTTDPTKRWEYCDIPRC------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------TTP---------------PPPPSPTYQ-CLKGRGENYRGTVSVTVSGKTCQRWS EQTPHRHNRTPENFPCKNL-EENYCRNPDGETAPWCYTTDSQLRWEYCEI----PSCESS A------------SPDQSDSSVPPEEQTPVVQECYQ-SDGQSYRGTSSTTITGKKCQSWA AMFPHRHSKTPENFPDAGL-EMNYCRNPDGDKGPWCYTTDPSVRWEYCNL----KRCS-- ---------ETGGSVV----ELPTVSQEPSGPS-------------------DSE----- -----------------------TDCMYGNGKDYRGKTAVTAAG---------------- ----TPCQGWAAQEPHRHSIFTPQTNP--RAGLEKNYCRNPDGDV--------------- ---NGP---------WCYTTNPRK----------------------------LYDYCDIP LCASASSFECGK------PQVEPKKCPGRVVGGCVANPHSWPWQISLRTR---------- -FTGQHFC--GGTLIAPEWVLTAAHCLEKSSRPEFYKVILGAHEE--------------- ----------YIRGLDVQEISVAKLILEPNNRDIALLKLSRPATITDKVIPACLPSPNYM VAD-------------------------------------------------RTICYITG W-----------------------GETQGTFGAGRLKEAQLPV----IENKVCNRVEYLN NRVKSTELCAGQLAGGVDSCQGDSGG--PLVCFEKDKYILQ------GVTS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------WGL GCAR-----------------------------P------------------------NK PGVYVRVSRFVDWIEREMRNN------------------- >SIG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------+---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------+------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ APOB >H sapiens --------------------MDPPRPALLALLALPALLLLLLAGARAEEEML--ENVSLV CPKDATRFKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCT LKEVYGFNPEGKALLKKTKNSEEFAAAMSRYELKLAIPEGKQVFLYPEKDEPTYILNIKR GIISALLVPPETEEAKQVLFLD-TVYGNCSTHFTVKTRKGNV-ATEISTERDLGQCDRFK PIRTGISPLALIKGMTRPLSTL---ISSSQSCQYTLDAKRKHVAEAICKEQHLFLPFSYK NKYGMVAQVTQTLKLEDTPKINSRFFGEGTKK---MGLAFESTKSTSPPKQ--AEAVLKT LQELKKLTISEQNIQRANLFNKLVTELRGLSDEAVTSLL----------------PQLIE VSSPITLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVALIPEPSAQQLREIFNM ARDQRSRATLYALSHAVNNYH------KTNPTGTQELLDIANYLMEQIQDDCT---GDED YTYLILRVIGNMGQTMEQ-------LTPELKSSILKCVQSTKPSLMIQKAAIQALRKMEP KDKDQ-EVLLQTFLDDASPGDKRLAAYLMLMR-SPSQADINKIVQILPWEQNEQVKNFVA SHIANILNSEELDIQDLKKLVKEALKESQLPTV-MDFRKFSRNYQLYKSVSLP-SLDPAS AKIEGNLIFDPNNYLPKESMLKTTLTAFGFASADLIEIGLEGKGFEPTLEALFGKQGFFP DSVNKALY-WVNGQVPDGVSKVLVDHFG-------------YTKDDKHEQDMVN----GI MLSVEKLIKDLKSK------------EVPEARAYLRILGEELGFASLHDLQLLGKLLLMG ARTLQGIPQMIGEVIRKGSKNDFFLHYIFMENAFELPTGAGLQLQISSSG--VIAPGAKA GVKLEVAN-MQAELVAKPSVSVEFVTNMGIIIPDFARSGVQMNTNFFHESGLEAHVALKA GKLKFIIPSPKRPVKLLSGGNTLHLVSTT-KTEVIPPLIENRQSWSVCKQV--FPGLNYC TSGAYSNASSTDSASYYPLTGDTRLELELRPTGE-IEQYSVSATYELQREDRALVDTLKF VTQAEGAKQTEATMTFKYNRQSMTLSSEVQIPDFDVDLGTILRVNDESTEGKTSYRLTLD IQNKKITEVALMGHLSCDTKEERKIKGVISIPRLQAEARSEILAHWSPAKLLLQMDSSAT AYGSTVSKRVAWHYDEEKIEFEWNTGTNVDTKKMTSNFPVDLSDYPKSLHMYANRLLDHR VPQTDMTFRHVGSKLIVAMSSWLQKASGSLPYTQTLQDHLNSLKEFNLQNMGLPDFHIPE NLFLKSDGRVKYTLNKNSLKIEIPLPFGGKSSRDLKMLETVRTPALHFKSVGFHLPSREF QVPTFTIPKLYQLQVPLLGVLDLSTNVYSNLYNWSASYSGGNTSTDHFSLRARYHMKADS VVDLLSYNVQGSGETTYDHKNTFTLSCDGSLRHKFLDSNIKFSHVEKLGNNPVSKGLLIF DASSSWGPQMSASVHLDSKKKQHLFVKEVKIDGQFRVSSFYAKGTYGLSCQRDPNTGRLN GESNLRFNSSYLQGTNQITGRYEDGTLSLTSTSDLQSGIIKNTASLKYENYELTLKSDTN GKYKNFATSNKMDMTFSKQNALLRSEYQADYESLRFFSLLSGSLNSHGLELNADILGTDK INSGAHKATLRIGQDGISTSATTNLKCSLLVLENELNAELGLSGASMKLTTNGRFREHNA KFSLDGKAALTELSLGSAYQAMILGVDSKNIFNFKVSQEGLKLSNDMMGSYAEMKFDHTN SLNIAGLSLDFSSKLDNIYSSDKFYKQTVNLQLQPYSLVTTLNSDLKYNALDLTNNGKLR LEPLKLHVAGNLKGAYQNNEIKHIYAISSAAL-SASYKADTVAKVQGVEFSHRLNTDIAG LASAIDMSTNYNSDSLHFSNVFRSVMAPFTMTIDAHTNGNGKLALWGEHTGQLYSKFLLK AEPLAFTFSHDYKGSTSHHLVSRKSISAALEHKVSALLTPAEQTGTWKLKTQFNNNEYSQ DLDAYNTKDKIGVELTGRTLADLTLLDSPIKVPLLLSEPINIIDALEMRDAVEKPQEFTI VAFVKYDKNQDVHSINLPFFETLQEYFERNRQTIIVVLENVQRNLKHINIDQFVRKYRAA LGKLPQQANDYLNSFNWERQVSHAKEKLTALTKKYRITENDIQIALDDAKINFNEKLSQL QTYMIQFDQYIKDSYDLHDLKIAIANIIDEIIEKLKSLDEHYHIRVNLVKTIHDLHLFIE NIDFNKSGSSTASWIQNVDTKYQIRIQIQEKLQQLKRHIQNIDIQHLAGKLKQHIEAIDV RVLLDQLGTTISFERINDVLEHVKHFVINLIGDFEVAEKINAFRAKVHELIERYEVDQQI QVLMDKLVELAHQYKLKETIQKLSNVLQQVKIKDYFEKLVGFIDDAVKKLNELSFKTFIE DVNKFLDMLIKKLKSFDYHQFVDETNDKIREVTQRLNGEIQALELPQKAEALKLFLEETK ATVAVYLESLQDTKITLIINWLQEALSSASLAHMKAKFRETLEDTRDRMYQMDIQQELQR YLSLVGQVYSTLVTYISDWWTLAAKNLTDFAEQYSIQDWAKRMKALVEQGFTVPEIKTIL GTMPAFEVSLQALQKATFQTPDFIVPLTDLRIPSVQINFKDLKNIKIPSRFSTPEFTILN TFHIPSFTIDFVEMKVKIIRTIDQMLNSELQWPVPDIYLRDLKVEDIPLARITLPDFRLP EIAIPEFIIPTLNLNDFQVPDLHIPEFQLPHISHTIEVPTFGKLYSILKIQSPLFTLDAN ADIGNGTTSANEAGIAASITAKGESKLEVLNFDFQANAQLSNPKINPLALKESVKFSSKY LRTEHGSEMLFFGNAIEGKSNTVASLHTEKNTLELSNGVIVKINNQLTLDSNTKYFHKLN IPKLDFSSQADLRNEIKTLLKAGHIAWTSSGKGSWKWACPRFSDEGTHESQISFTIEGPL TSFGLSNKINSKHLRVNQNLVYESGSLNFSKLEIQSQVDSQHVGHSVLTAKGMALFGEGK AEFTGRHDAHLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVRFPLRLTGKIDFLNNY ALFLSPSAQQASWQVSARFNQYKYNQNFSAGNNENIMEAHVGINGEANLDFLNIPLTIPE MRLPYTIITTPPLKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKHRHSITNPLAVLC EFISQSIKSFDRHFEKNRNNALDFVTKSYNETKIKFDKYKAEKSHDELPRTFQIPGYTVP VVNVEVSPFTIEMSAFGYVFPKAVSMPSFSILGSDVRVPSYTLILPSLELPVLHVPRN-L KLSLPDFKELCTISHIFIPAMGNITYDFSFKSSVITLNTNAELFNQSDIVAHLLSSSSSV IDALQYKLEGTTRLTRKRGLKLATALSLSNKFVEGSHNSTVSLTTKNMEVSVATTTKAQI PILRMNFKQELNGNTKSKPTVSSSMEFKYDFNSSMLYSTAKGAVDHKLSLESLTSYFSIE SSTKGDVKGSVLSREYSGTIASEANTYLNSKSTRSSVKLQGTSKIDDIWNLEVKENFAGE ATLQRIYSLWEHSTKNHLQLEGLFFTNGEHTSKATLELSPWQMSALVQVHASQPSSFHDF PDLGQEVALNANTKNQKIRWKNEVRIHSGSFQSQVELSNDQEKAHLDIAGSLEGHLRFLK NIILPVYDKSLWDFLKLDVTTSIGRRQHLRVSTAFVYTKNPNGYSFSIPVKVLADKFIIP GLKLNDLNSVLVMPTFHVPFTDLQVPSCKLDFREIQIYKKLRTSSFALNLPTLPEVKFPE VDVLTKYSQPEDSLIPFFEITVPESQLTVSQFTLPKSVSDGIAALDLNAVANKIADFELP TIIVPEQTIEIPSIKFSVPAGIVIPSFQALTARFEVDSPVYNATWSASLKNKADYVETVL DSTCSSTVQFLEYELNVLGTHKIEDGTLASKTKGTFAHRDFSAEYEEDGKYEGLQEWEGK AHLNIKSPAFTDLHLRYQKDKKGISTSAASPAVGTVGMDMDED-DDFSKWNFYYSPQSSP DKKLTIFKTELR--VRESDEETQIKVNWEEEAASGLLTSLKDNVPKATGVLYDYVNKYHW EHTGLTLREVSSKLRRNLQNNAEWVYQGAIRQIDDID--VRFQKAASGTTGTYQEWKDKA QNLYQELLTQEGQASFQGLKDNVFDG-LVRVTQEFHMKVKHLIDSLIDFLNFPRFQFPGK PGIYTREELCTMFIREVGTVLSQVYSKVHNGSEILFSYFQDLV----------ITLPFEL RKHKLIDVISMYRELLKDLSKEAQEVFKAIQSLKTTEVLRNLQDLLQFIFQLIEDNIKQL KEMKFTYLINYIQDEINTIFSDYIPYVFKLLKENLCLNLHKFNEFIQNELQEASQELQQI HQYIMALREEYFDPSIVGWTVKYYELEEKIVSLIKNLLVALKDFHSEYIVSASNFTSQLS SQVEQFLHRNIQEYLSILTDPDGKGKEKIAELSATAQEIIKSQAIATKKIISDYHQQFRY KLQDFSDQLSDYYEKFIAESKRLIDLSIQNYHTFLIYITELLKKLQSTTVM--NPYMKLA PGELTIIL >H glaber MGARAAAQRVRVRARPQGTGMGRPRPALLLLLLL---LLLLDAGARAEDEAPERESVSPS CPKEATRFKHLRKYIYSYEAETSSGVPGTADSRSATKVSCKVELEVPQLCSFILKTSQCA LKEVYGFNPEGRVLLKKTKTSEAFAAAMSRYELRLAIPEGKQAVLYPEENEPAHILNIKR GIISALLVPPETEEAQQELFLD-TVYGNCSTHTAVKTRKGSV-ATEMSTERNLQQCSGFQ PASTGASPLALIKGLARPLSTL---ISSSQSCQYTLDPKRKHVSEATCKEQHLFLPFSYK NKYGMMTQVTQTLKLEDTPKINSRFFGGGTQK---VGLAFESTKSPSLPKQ--AEAVLKT LQELKKLSTSEQNAQRANLFNKLVTNMRGLSSEAITSLL----------------PQLIE VSSPITLQALVQCGQPQCYTHVLQWLKSEKAHPLLIDAVTYLVALIPDPSVQRLREIFSI AKEQQSRATLYALSHVANNYF------EATRTVDPDLQDIINYLQEQIQDQCA---GDED HAYLILRVIGNMGRTLES-------IAPMIKSSVLSCIRSPKGSVLIQKAAIQALRKMEL GYEDR-ELLLQTFADSTSPVEKRLAAYLMLMK-QPSQSDISSVIQLLPQEESEQVKNFVA SHVANILNSEELYVGDLKTLVKEALKDSQLPTV-MDFRKYSRNYHVSKSVSLP-SLDPVL AKIEGNLIFDPNNYLPKESMLKTTLTIFGFASADLFEIGLEGKGFEPTLEALFGKQGFFP DSVSKALY-WVNGQVPDRVSQVLVDHFG-------------YTKDDKHEQDMVS----GI MPIVDKLIRDLQSR------------DMPEARAYLRILGRELGFFKLQDLQLLGKLLLSG ARTLQGIPQMISEAIREGSEHDLFLHYIFMDNTFELPTGVGLQLQVSSSG--IISPGSKA GLKLQVAN-MQADLLMKPAVSVEFVTNMGVIVPDFARSGVQMNTNFFHESGLEARVALKA GQLKVIIPSPKRPVKLFSGSNTLHLISTT-KTEVIPPLMENRQSWSACRPF--LTGLHYC TAGAYSNASSTESASYYPLTGDTRYELELKPTGE-VEQYSASATYELQREDKALVDRLKF VIQAEGVKQAEATLMFKYNRRSRTLSTEMQIPDLDVNLGTILRVSDESSKDKRSYKLNLD IQNKKITEVALSGHISHDTKGEGKIKGVISIPRLQAEARSEILSHWSPTKLLLQMDSSAT AYGSTVSKRVAWRYDDEKVEFEWNTGTNVDTKKVASNFPVDLSDYLRSLYMHANGLLHHR IPQTDMSFWDMGSKVIVTTNTWLQEASSSLPYAQILQDHLSSLTELDLQKMSLPYFHIPD NLFLKSDGRVKYTLNKNSIEVDIPLPFGGKSSKDLKMFDTIRTPALNFKSVGFYLPSREF HIPTFTIPELYQLRVPLLGVLDLSTNVYSNLYNWSASYTGGNTSRDHFTLQARYHIKADS AVNLLSYSLQGSGETTYDHRNTFTLSCDGSLRHKFLDSNVKFSHVEKLGNNPASKGVLTF DASTTWGPQVSASVHLDSKKKQHLYVRDVKIDGQFGASSFYAKGTYSLTCQGDPATGQLS GESDLSFNSSYLQGTNQITGRYEDGALSLTSTSDLQGGTLKNTASLKYENYELTLKSDTN GKSENFAIRNRVDLTFSKQNALLHSEYEADYKSLKFFSLLSGSLNSHGVELNADILGTDK VNTAAHKATLSIGRSGISTSATTNLKYSPLFLENELNAELGLSGASMKFTANGRFREHST KFTLDGKAALTEVSLGSVCQAMVLGVDSKNIFNFRISGEGLKLSNDLKGSYGEITLDHAN SLNTAGLSLEFSSKLDNIYSSDKFYKQHFNFQLQPFSLVTTLNNDLKYSALGLTSSGKLR LEPLKLNVDGNLKGAYQNNEIKHIFTISYVDI-SASYKASTIARIQGMQFSHQLNTGIAG LVASLDTSTNYHSDSLRFSSALHSAVAPFALAINAHTNGNGKLALWGEHTGQLYSKFLLK AEPLALTFSHDYKGSTSHSLLSRESIGMALDHKLSALLTPSEQTGTWKLKTQLNSNEYSQ DFDAYNTKDKIGVELSGRGLADLTVLDSPIKVPFFLSEPINIIDTFRMKDTVQQPQEFTI AAAIKYDKNQDVHTISLPFFKSLPEYLEKNRLMIITALEAMQKELKSLNIDQFVGRYRAG LGKLPQQVNDYLTAFNWESQVASGKEKLTAFAENYRITENDVQTALNNAKISLNENLSQL QTYVIQFDQYIKDNYDLHDLKIAIVRIIDRIIENLKILDEHYHIRENLVRTIHNAYLFIE NIDFSKMGSSTASWIQNVDTQNQIRIQIQEKLQQARTQIQNIDIQELAAKLKQQVEAIDT RALLNQVRTTIPFQRIKDIIEHVKYIVISLIEDFEVTEKINAFRAIAHELIKKYEVDQQI QVLLDKSVQLARQYKLKDTVQKLSNLLQRVDMKDCYKKLLVFIDDIIRQLKAFSFKNFME EVNQFLDALVKKLRSFDYHQFVDETNHKIREVTQIINAELQVLDLPQKAEALKLFVEDVR VMLSAFLEKLKDTKITVFVDWLQDALNTAYLVPIKAKFQETLEDIRDRIYQMDIQQELER CLSLVGQVYSTLVTYVSDWWVLAAKNLTDFAEQYSIQGWAENVKALVEQGFTVPRIQLIL GTVPAFEVSLRALQEASFQTPIFTVPLTDLRIPSVRINFKELKDIKIPPRFSTPEFTVLN TFHIPSFTVDFLEIKLKIIRTIDQMLSSEFQWPVPEVYVGDLKVEDILPARLFLPNFHLP EITIPEFLIPNLNLTEFQVPDLHIPEFQLPPISHSAEIPALGKLNSILKIQSPLFTLDAK ADIHNITTSEHQTGTEVSIAAKGESKFEVFNFDFQANAQLLDPKTNPLLLKESMNFSSKH LRMEHKSEILFSINAIEGKSDTVASFSTEKNTLELNNGVVVKMKGQLTLDNHMKYFHKLS IPKLDFSSKADLRNDLKTLLKVGHITLTSSGAGSWKWACPSFSDEGTHESQINFTVEGPL ASLGLANKINSKHLRVTQNLAYESHFLNFSKFEIRSDVESQHVGHSILTAKGTALLGKGK AEITGDHSAHLSGKVIGTLKNSLFISAQPLEITASTNNEGNLKVSFPLRLTGKIDFLNNY ALLLSPSAHQTSWQASAGFNQYKYNHNFSASNNENSIDAHVSINGDANLDFLNIPLTIPE MNLPYTTFKTPSLKDFSIWEETGLKEFLKTTKQSFDLNVKIQYKKNKDKHTIAVPLGVFY KFISQNVNSLDSYFENVRDNALDFLTTSYNELKIKLDEYKAERSLNKLPRTFPRPGYTIP IVNVEVTPFSVEMLPSGHMIPKAVHTPSFTIPGFDFYVPSYMLSPPSIELPDLHIPRNLL KLSLPDFKGLSTVNNIFIPAMGNITYDFSFKSSVITLNTNAGLYNQSDIVAHFLSSSSFV IDALQYKLEGTSRLTRKRGLKLATALSLSNKFVEGSHDSTISITKKIMEASATTTAKVHI PVLRMNFKQELNGNTKSKPTVSSSIELTYDFNSPKLFSSAKGAIDHKLSLESLTSYFSIE SSTKGDIEGLVLSREYSGAIASEASTYLSSKATRSSVKLQGSSKVDGIWNVEVKENFAGE ATLRRMYAMWEHSMKNHLQPYSGFSTHGEHTSKATLELSPGSVSALIQVRAREINSVLDI PHLGQEVALNANTKNQKFSWKSEVQGQLGTLQNHVQLSNDQKEARFDIAGSLEGRLHFLK FITLPVYDKSLWDLLKLDVTTSSQKRQYLHASTALVYTKNPKGYPFSVPVQELTDEFIVP GLKLSDLSSDFATPTFRVPFTDLQIPSYKLDFNEIRIYKKLSTSPFALNLPTLPKVKFPQ VDVLTKYSEPEDSSVPFFEITIPDVQLTVSQFTLPKSLSVGSAVLDLSEVANMIGDFELP TITVPEQTIEIPSMKFSVPAGVFIPFFGALTARFGVASPLYNATWNVGLKNKADHVETFL DSTCSSTLQFLEYDLNVVGTHSLEDGMLICKIKGTLAHRDFSAEYKEVDKYKGLKAWEED VNLDILSPAFTELHLRYREDENSMSFSAASPAVGTVGLDLETEGDRSFKGNLYFQPQSSP GRKLNIFKTEWR--YQESDDKIQMKFNWEEEAASRFLGSLKDNVPKATGAFYDYVDKYHQ EYTGLSLKDASSKLRRSLRESAEGAYQRARRQINKMD--VGLQRAASSTIGTYQEWKEKA QDLYQELLAEEGQASSQRLKDKVFDS-LFQATQEARMAAKCMMDSSIGFLQLTRIQLPGI AGTYTGEELCTMVIKEIGKVLSWAYSNIHSELEKLLSYAQDLVEKSELIKDLQITFPFYS ESYKLTEVILKSRKLLEFLSKNVQDVFIDLQSIKLSETLGDLQSSLQIIFERIEEEIKYL KETRFIHPIN----AIDTIFNTYIPFAFRVLKESLYLNLTKFNEAVQNNLQVASQGLQQT HQYLKALREEYFDPSIVGWTVKYYALEEKMVDLVMDLVIALKNLHSTYTAYAASSASQLS ALVEQFVHKDVQEYLSILADADRRGKEKIAELSNSAQQVIKTLTTAMKEIVSDYLEQFIS KLQEFLDQFPDYYEKFIAESQRLIDLAIQSYHVILSYITELLKKLQAATASGGNPYVKLA PGELTITY >M brandtii --------------------MGPSGPALLALL-----LLMITAGARAEDEVL--ENVNPS CSKGTTRFKHLRKYVYNYEAESSSGAPASTDSKSVTKINCKVELEVPQLCSFILKTSQCT LKEVYGFSPEGQALLKKAKNSEEFSAAMAKFELRLATPEGKQVLLYPDKEEPKHILNIKR GIISALLVPPETEEDKQMLFLD-TVYGNCSSDVTVKTRKGNV-ATEISIERNLEKCDHFK PVSTGVSPLALIKGLTQPLSTK---ISSSQSCQYTLDPKRKHVSEAICQEQHLFLPFSHK DKYGMMALVTQTLKLEDTPKINSRFFDEGTEE---VGLTFETTKSTSPPKQ--AEAIVKT LQELQKLHVSEQNAQRANLFSRLVTELRGLNNEAVASLL----------------PKLGE VSSPITLQALIQCGQPQCYTHILQWLRNEKANPLLIDVVTYLVALIPGPSAQRLQEIFNT AKEQQSRATFYALSHVIHNYH------KTHPTATQELLDIADYLLEQIQDDCT---GNED HTYLSLRVIGNIGGTLQK-------LTPRLTSSVLKCIKSTAPSLLIQKAAIQALRKMEN KDEVR-EVLLQTFLDEAAPGDKRLAAYLMLMR-DPSQSDISKVTQLLPGEQNEQVKNYVA SHVANILNSDELYVQSLKELVKEALKDSQLPTV-MDFRKFSRNYHFSKSVSLP-SLTPFS TKLEGNLIFDPDNYLPKESMLKTTLTVFGFESADLFELGLEGKGFEPTLEAFFGKQGFFP DSVNKALY-WVDGKVPDRVSEVLEDHFG-------------YTKDDKREQDMVK----GI MGNVEKLIKDLKSK------------DFPEARAYLRILGEELGFVKLDDLQLLGRLLLNG VRTLKGIPHMVAEALKKGSKNDLFLHYIFMDNAFELPTGLGLPLQVSSSG--VLAPGIQA GVKLEVKDKMQMELVTKPSVSVEFVTNMGIVIPDFARNGVQMNTNFFHETGLEARVGLNL GHLKFSIPAPKRPVKLFSVSNTMHLVSTT-KTELIPPLKENRNSWSTCKPF--FTGLNYC TTGTYSNTS-----SYSPLTGDTRYELELRPTGE-VEQYSASATYNLQKEGKARVDTLEF VAQAEGVKQTEATMTIKYNRQTMTLTSETQIPDFGIDLGTVLRVSDESAEEKTSYKLTLD IQNMKITEVAFTGHISYDKKEEAKIKGVLSVPRLQAEARSETLAQWSPTKLLLQMDSSAT AYGSTISKKLAWRYDEEKIEFEWNAGTDVDTKKAASSFPVDLSDYPKSLHMYTNRLLDHR VPKTDMTFRHMGSKLMVATNTWFQKAFASLPYTQNLQEY---LKQLNLQKMELPEFHIPE NLFLKSDGRVKYTFNKNSVKIEIPLPLGGKSSKDLKMLETVRTPVISLPFLGFYQPPQEF QLPNFTIPKLYELRVPHLGVLDLSTNIYSNLYNWSASYTGGNTSTDHFSLQARYHMKADS AVDLLSYSVQGSGETTYDHRNTFTLSCGGSLHHKLLDSNVKFSHVEKMGNNPASKGLLTF DASSPWGPQMSASVHLDSKQKEQLYIKEVKIDGQFRVSSFYANGAYGLSYQKDPASGQRT GESNLRFNSTYLQGTNQIIGRYEDGTFSLTSSSDLQDGIIKNTASLKYENYELTVKSDTN GQYQDFTTSNKVELAFSTQKASLSSVYQADYKSLRFFTQLSGSMNPHGLELNAEILGTDK INTGAHKATLRIARDGMSTSATTNLKYSPLMLENELNAALGLSGASVKLTTNGRFREHNA KFSLDGKAALTEVSLGSAYQAMILGVDSKNIFNFKINQEGLKLSNDMMGSYAEMKLHHTH SLNMAGLSLDFSSKLDNIYSSDKSYKQTFNLQLQPYSLVTTLNNDLEFNDLDLTNHAKLR LEPLKLNVGGNIKGAYRNDEIKHIYTLSYADL-SASYKADTVAKVQNTEFSHRLSTNIAG LASTTDISTSYNSDSLHFSNVFHSVMAPFTVTVDVHTNSNGKLVLWGEHTGQLYSKFLLK AEPLALTFSHDYKGSTSHHLMSKRSVSTALDNKVGALLTPAEQTATWKLKTQVNKNEYTQ EFDAYNTKDKVGMDLTGRALADLTMLDSPIEVPFLVRDPVNVIDALEIKDTIDQPQEFTM VASVKYDKNQDVHTINLPFFNLLPEHFEKSRIIIITALEAIQRELKHIDIDQFVMKYRAA LDKFSEKVNVQLNEVNWETQVSRAKEKLTAFIKNYGITENDLKMALDNAQINFNETLSQL QTYVIQVDQYIN-----YDVKAAIAKIIDQIIEKLNILDKHYRIRVTLVKVIHNLHLFIE KVDFNKVGSNTVSWIQNVTDRYQIRIQVQEKLQQLKTQIQNFDMQHLAEKLKQQIEAIDV RVLLDQLRAAISFQKIKQMIEHVKNYVGKLIEDFEVTKKINAFRTMVHKLINRYKIEQHI QILIDKSVQLAQKYKLKETLQKLGNVLKQVGIKDHFEKLVGFIDDAVTQLKALSFKNFIE EVNRFLDMLISKLRSFDYHRFIDETNNKIREVTRIINEEIQALDLPQKAKALKLFVEDIK AAVSVHLENLNSTKITLFIDWLQEALRSPSLNHMKAKFQETLEYIRDQMYKMDLQQKVQQ CLLQVGEIYNTIVTYISDLWSLAVKNLTDFAEQYSMQDWAENLKALVEQGFIVPEIQTIF VTIPSFEVSLRALQEATYQTPEFIVPLTDLKVPSVQINFKKLEDIKVPSRFSTPEFTVLN TFHIPSFTIDLVEIKAKIIRIIDQMLNSELQWPVPEVYLKDLMDTDTILARITLPDFHVS EITIPEFVIPKLDLKAFQIPDLHIPEFQLPKISQTIEVPTFGKLHSVLKIQSPLFTLDAN ADIHNVTTSVNEAGITASITAKGHSKFEVLKFDLQANAQLSYPKMKPLVLKESVSFSSKY LNTEHKSEVLFFENTFEGKSNTVAGLQTEKNTMELSNGVLIKINNQITLDSNTKYFHKLN IPKLDFSSQADLHDEIKTLWDSEKIAWTSSGRAAWKLACPKFSDEGTRESQISFTMRGLL TSFEFSNKINSKHLRVNQTLAYESGFLNYYQLEIQSQVESQHVGHSILTAKGTAQLSERK VEVTGNHDAQLNGKVSGNLKNSLFFSAIPFEITASTNNEGNLKVIFPLKLTGKIDFLNNY ALFLSPNAQQASWQAGARFNQYKYNQNFSAGNNENSTDAHIGISGEANLDFLNSPLTIPE MTLPYTGFKIPQVKDFSLWEKTGLKEFLKTTKQSFDLSVKAQYKKNKDKHSIPIPLDVFY VFINQNINSFNRHFEKVRGKALNLFTKSYNEAKIKLNKYMVEKSLNKEPMTLQIPGYTIP VVNTELSPFTAKMWTFGF----EIRTPNLTTPDSGFYVPSYAIVLPSLELPALNVPRNFL KFSLPELKVLS-IPNILIPAMGNITYDFSFKSSVITLNTNVGLYNQSDIVAHFLSSSSSV IDALQYKLEGSSSLTRKRGLKLATALSLSNKYVEGNHDSTISLTKKTMEASVTTTANVQI PILRMNFKQELNGNTKSKPTVSSSIELKYDFNSTKLYSTATGTVNHKFSLESLTSYFSIE LSNKGDIKGSVLSREYSGMIASEVSTYLNSKGTRSSVKLQGASKVDRLWNLEVKESFAGE ASLQRIYATWEHNTKNHVQVL-YPLTSGEHSGKATLELSPWKMSALAQVHASQLSSFLDL NHLGQEMSLNVNPENQKASWKGEVQVHSLSLQNDVQLSNDQDETRLDIAGSLEGYLKFLD SIALPVYDKTLWEFFKLDVTTSKDRKQYFHASTALVYTKNPKGYTFSVPVQELADKFVIP GLRLNNLNSVLLTPAFQVPFTDLQVPSYTLDFSEIKIYKKLSTSPFSLNVPALPKVKFPE VDVLTKYSGPEDSSVPFFEITVPGFQLTMPQFTYPNSISVGATVLDLNEMAGKIADFRLP NITVPDQTIEIPSIKFSIPSGIYIPSFGALTARFGVASPLYNATWNAGLKNKEDHVETYL DSTCSSIIKFLEYDLKGIGTYKIEDGMFVYKAKGTFTHRDISVEYKEDAKLQEYPDWKVE VLLDITSPVFTDVHIHCHAREN-VFYSAASPAIGTVVLDLGSD-NTTITYNFYYRPQSSP DKNLSIFKIEYRHPYSESNEKFQIKVNWEKEAVSQLLSSLKDNVPKATGALYDYVNKCHQ EYTGLNLREASLKLRRGLQNKAEETYQGALILIDKVNKTLEFKRVARGAARTYQLWNDKV QILYQDLLDQEGHIDLQRLQNKVLNI-LINITREYETIVRHVIAWFIDYLQLTRLQLPGR ASTNTADELSTLVMRGVGKILLQVHLNIHNGLEILFSYVQGLMEKSELIKDLKIKFPFDS RSLKLTNITLEYGKQLNSFSQMVQRVLNALKSNKTTVILGDLQRYLEGVFEYIREEINDL KMKRLTVIKH----KIKVIFDSCIQYVSQFLKENLGLDVGKLHELVQNKFQEASQELEQL HQYIKALRKEYLDSSVVSWTLKYYEYEEKVINLVKKLVHALKYFHSKYIVNAAGIASQLS NEAEQLVQQAIPKYLSILVDADGKGKEKIVELFTSAKEIIKSWTAAMKEIISDYHQQFKY IPQNFSDRLFDYYEKFIAESQRLIDLSIQTYHMFLIYITGLLKELQSTTVYDLSRYLKIA PGELTITF >S franciscanus -------------------HILNAKRGILSMI---------------------------- ----------------------------------------QLDLEADD-------VDQIT L------------------------EEMSAHDLVFRTENGRIVEVLAHPDEPLHILNAKR GILSMIQLDLEADDVDQITLNEVSVHGNCSSEMTVTRRDDKQRPRKLQVVTDLNNC-MLR KQPENMTRWQSFKDIVSNMVIMDKVINSSKTCSYDLKGTTGEFRGIQCEEVHSFWPMNFN SESGVRTFIQQSLISTIIAPLNSFKVDPAVSRSTCLRYEHDSKEIGKKPDDITADQAMDI LKALVKSSREEVKMESPRLFGRWRAALEGMNNDTIHEVFDRAYNCSAYSQTCRDNPDKEK IAREYLLDGLLPCTTMACFSVKNYAIAKGVVPKPLASAWMVTMALQNYPTLELMSEMLRM AQYSPSQITIFPLSIMVHNYWMNNEEIHTADTVPEPIVKTIRYLKSLIGNDCTVSAEKER LALVAIKAIGNIGEPVERYDQLTFIFSERLSPVLISCTKNKQIPRDISKAAIQSMRRFVM SDQLRSQVISELFKDTTLDVPQRIAAYLITMKANPSVSELTDIWNFLKTEPVNQMKAFCY SHIQNIIESSEPTLQEVLFLI-ISLKLKLLQEYPKDIRKYSRFFELSKNLTEPWRNNTVA AQLESDIIFSPESYLPQEVMFHYVLNALG-KSWDIFE-------FEPIIESVFGPEGFFP EVKLQTMFDTIDEKFLSKVREFAEAQLGNWVTPTSEPDNEVFNKKGKYGKKMKRQSPIKC IQVIDVIHENTMNKLNQLHYLVGMEPSATDATVFLRLLGNEFGFVSASDVLALIPYTMGI YEELMNKTKQVPQLLSQGLNLNTTRSLVFMDKSFILATGMGMPLNCSINGTAVVSLRMKS QFSINLPKIIAAGYVA-PSGAVEVLATMGIGLPTKVFTGVMANATVYHSSKIAGNITIDG THLKINLNNTDRPMNLFNYSTTYNLLKANGDIEFIPGVLQDAVQSQRCTNVSKVFGVDLC VSWAYPNASYVAEAPRFPFSGPNSFNVTLVNYFRALKAYTIDAQYKQIREGGA------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PAPIS----------------- -------FSSIGRR----------------------------------NKQNAPAFT--- -----------------------------------KLIDTVR--------VSFYAPGNK- ----------------------LTRNITSLV------------SVDRLRKTAKW------ ---------------------TFTV--------------------------PEVKNFIMF ------------------------------------------------------------ ------------------------------------AGILNETTDS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSSYRA--------------------- --------------------VFNVSAAENTASVD----------------------FLVR NE----------------TSLAQKNLTAVFNASINSL----------------------- ------------------------------------------------------------ --------------------------------------------------------YWAA VGQFVKQ----------------------------------------------------- ------------------------------------------------------------ --------SNNGDWNAHLTDTY-------------------------------------- ------------------------------------------------------------ -----------------------------------------YWDNETPLYKQLLFP---- ------------------------------------------------------------ --------------------WTGYQIN-------HAKYQTS------------------- --------------------TITARRIT--------------------RG---------- --------------------------------PVVQRDLKM------------------- ---------------------------GILDWA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FDFNTVQTVTDELKELTVHTQISNAT-----WVF---------------------PL LDVTLRNETKVNGYRLEGQVARNTHHI-FAEYEVTKE----------------------- ------------------------------------------------------------ --------------------PRETNRNFRMG-----LRTDVLVNNPDASMFLNSPVLL-- ----------------ELFGETSLID-----------------------EPVVIDGGANF RILDQS------------------------------------------------------ ------------SLTEEHLIQTSIFVPN---------------------------PRN-- -------------------PQTHLTYDFDLRLE------NATISNQKD------------ -----YSLELTT----------------------------------------------PI ILMQMN------------------------------------------NVNFLHLMIDME S---------------------------------------------------------GT STLDHTYTLYD------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TRYSKP--------------------QVTVSNSIGAGWK----KPSANWVMDIATP SM-------------------VYFQNYTAL------------------------------ --------------------YSSENGL------------QFFYENSQDSSVYDLLDLILT DNLSVK------------------------------------------------------ --------------------------------------------PSAVSMYTSYIHQL-- ---------ISTNVSNSLVVDGPVTEMRPRL----------------------------V PMIVRDILNKTFRRDFSSVKDLVLNKFIFNVTS--------------------------- ---------STITLRQSANMSSPIIANMSASHYIFLS--QSLFDQ---------KLSFAA EQKRL-----------------------------------NISAGLNHSLLIEDREITLK TEGDVAV-------RTGLRMSTLTSVNVTISKPDTPFDLAALH----------------- ----------------------YTEVNSPLIR----------------------FSTRSS S------NGNFHEVLNMAANHN-------------------------------------- --------------------------------------TSMTSRL--------------- -GSFDVIG >S purpuratus ---------------------MRAVSFLLVSLLLATAVVAGPFGTRFGQEV----EPELE CS-ELTRFKEGYSYTFNYEAETESGIKGAGPGSTST-MTCNIAIEAPERCRNVLKVTSCS L-----------------DGNPQLGDEMSAHDVVYRTDKGRIIEVVAHPDEPIHILNAKR GILSMIQLDLEADDVDQITLNEVSVHGNCSSEMTVTKRDDRQRPRKLQVVTDLNNC-MLR KRAENMTRWQSFKDIVLNMTVMDKFINSSKTCSYDLKGTTGEFRGIECEEVHSFWPMNFN SDSGVRTYIQQRLISNTIENLNSFKVDPAISRSTCLSYELDPKDVGKKPDDVTADQAMDI LKALVKSSREEVRMESPRLFGRWRAALEGMNNETIHEVFDRAYNCSAYSQTCRDNPDKEK IAREYLLDGLLPCTTMACFSVKNYAIAKGVVPKPLASAWMVTMALQNYPTLELMSEMLRM AQYSPSQITIFPLSIMVHNYWMNNEEIHTAATLPEPIIKTIRYLKSLVGNDCTVSAENER LALVALKAIGNIGEPVERYDQLTFIFSERVSPVLISCTKNKQIPRDISKAAIQSMRRFVM SDQLRSQVISELFKDTTLDVPQRIAAYLITMKANPSVSELTGLWSFLKTEPVNQMKAFCY SHIQNVVESSEPTLQELKKNLKIAMIGEELPEYPKDIRKYSRFFELSKNLTEPWRNNTVA AQLESDVIFSPESYLPQEIMFHYVLNALG-KSWDIFETGIEMKGFEPIIESVFGPEGFFP EVKLQTMFETIDEKILSKVREFAEAQLGNWVTPTSEPDNEVYNKQGKYGKKMKRQSSFGE PQVVDMIHENTMNKLNQLHYLVGMEPSATDATVFLRLLGNEFGFVSASDVLALIPYTMGI YEELLNKTKQIPQLLSQGLNLNTTRSFVFMDKSFIVPTGMGMPLNCSINGTAVVSLRMKS QFSINLPKIIAAGHVA-PSGAVEVLATMGIGLPTKVFTGVMANATVYHSSMLAGNITIDG THLKINLNNTDRPMNLFNYSTTYNLLKANGDIEFIPGVLQDAVRSQRCTNVSKVFGVDLC VSWAYPNASYVAKAPRFPFSGPNSFNVTLINTDQALKAYTIDAQYKQIREGGA------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PAPMS----------------- -------FKSIGKR----------------------------------SKQNAPAFT--- -----------------------------------KLIDTVR--------VSFYAPGEE- ----------------------LTRNITSLV------------SVDRLRKTAKW------ ---------------------TFTV--------------------------PEVKNFIMF ------------------------------------------------------------ ------------------------------------AGILNETTDS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSSYRA--------------------- --------------------VFNVSAAENTASVD----------------------FLVR NE----------------TSLAQKNLTAVFNASINSL----------------------- ------------------------------------------------------------ --------------------------------------------------------YWAA VGQFFKP----------------------------------------------------- ------------------------------------------------------------ --------SNNGDWNAHLTDTY-------------------------------------- ------------------------------------------------------------ -----------------------------------------YWDNETPLYKQLLFP---- ------------------------------------------------------------ --------------------WTGYQIN-------HAKYQTS------------------- --------------------TITARRVT--------------------RG---------- --------------------------------PMVKRDLKM------------------- ---------------------------ATLDWA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FDFNTVQTVTDELKELTVHTQISNAT-----WEF---------------------PL LDVTLRNVTNVNGYRLEGQVARSTHHI-FAEYDVTKE----------------------- ------------------------------------------------------------ --------------------PRETNKNFRMG-----LRTDVLVNNPDVSMFLNSPVLL-- ----------------KLFGETALID-----------------------EPVVIDGGVNF RILDQS------------------------------------------------------ ------------SLTEERLIQTSIFVPN---------------------------PRS-- -------------------PQTHLTYDFDLRLE------NATISDRKD------------ -----YSLELTT----------------------------------------------PI TLLKIN------------------------------------------NINLLHLMIDME S---------------------------------------------------------GT STLDHTYTLYD------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TRYSKP--------------------QVTVSNSIGAGWK----KPLANWALTIETP SS-------------------VYLQNYTAL------------------------------ --------------------YTSDNGL------------QFFYENSQDSSLSDLLNFIEI SNWSVR------------------------------------------------------ --------------------------------------------PSAISMYTSYIHQL-- ---------ISTNVSNSLVLGGPVTEMRPRL----------------------------V PMIMRDMLNKSFSRDFSSVKDLVLNKFIFNVTS--------------------------- ---------STLTLRQSANMSSPAIANLSASHYIFLS--QSLFEQ---------KLSFAA EQKRL-----------------------------------NISAALNHSLLIEDREITLK TEGDLAV-------RTGLRMNTLTSVNVTMSKPDTPFDLAALH----------------- ----------------------HTEVNSPLIR----------------------FSTRSS S------NGGFREVLNMVANHN-------------------------------------- --------------------------------------TSMTSRM--------------- -GSFDVIV >L variegatus ------------------------------------------------------------ --------------------------------------------ESPERCKHVLKVTSCH L-----------------DGNNQLGEEMSAHDLVFRTENGRIIDVLAHPDEPLHILNAKR GILSMVQLDFEADDVDQITMNEVSVHGNCSSEMNVTQRDERQRPRKLEVVTDLNNC-MLR KRPENMTRWQSFKDIVFNQTIMDKVINSSKICRYDLKGTTGEFKGIECEETHSFWPMNFN SESGVRTFIRQNLISTNIDWLNSFKVDPAVTRSTCLRYEHDPKEVSQKPNDVTADQAMDI LKALVKISREEIKMESPRLFGRWRAALEGMTNETIHEVFDRAYNCSEYSQTCRDNPDKFP LYREYLLDGLLPCTTMACFSVKNYAIAKGIIPKPLANAWMVTMALQNYPTLELMSEMLRM AQYSPSQITIFPLSIMVHNYWVNNEEIHTAEELPEPIIKTIRYLKSLIGNDCTVSAENQR LALIFIQAIGNIGEPVERYDQLAFIYSERVSPVLIECTKNKQIPSDISKAAIQSMRRFVM SDQLRSQVISELFKDTSLDVPQRIASYLIIIKATPSISELTEIWNFLKTEPVNQIKAFCY SHIQNVIESSEPTLQRLKENLKTAMNGEQLPEYPKDIRKYSRFFELSKNLTEPWRNNTVA AQLESGIIFNPESYLPQEVMFHYVLNALG-KSWDIFETGIEMKGFEPIVESVFGPEGIFP EVSLQTMFETIDEKFLSKVREFAEAQLEKWAPQPAETENEVFSKKDTIGKKMKRQTQIGE PQVIDVIHENTMNKLNQLHYLVGMEPSATDATVFLRLLGNEFGFVSAGDVLSLIPYTMGI YEEFMNKTKQIPQLLSQGLNINTTRSFVFMDKTFVLPTGMGMPL--------LLSSFLRF FCSSQFSQCFLNSYIC--SGAVEVLATMGIGMPTKVFTGVMANATVYHSSKIEGNVTIDG THLKINLNNTDRPMNLFNYSTTYNLMKANGEIEYIPGVLQDAVRNQRCTNVSRVFGVDLC VSWAYPNASYVAEAPRFPFTGPNSFNVTLVNTDQALKAYTIDAQYKQIRKGGA------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------PSPIT----------------- -------FSSIGRR----------------------------------NNRNTQETS--- -----------------------------------NIIDTVR--------VSFYAPGEE- ----------------------LTRNITSLM------------SVDRLRKTAKW------ ---------------------TFTV--------------------------PEVKNFIMF ------------------------------------------------------------ ------------------------------------AGLLNETTDS-------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------SSTYRA--------------------- --------------------VFNVSAAENTASVD----------------------FLVR NE----------------TSVSQKNLTAVFNASINNL----------------------- ------------------------------------------------------------ --------------------------------------------------------YWAA VGQFVKQ----------------------------------------------------- ------------------------------------------------------------ --------AESGDWNAHVTDTY-------------------------------------- ------------------------------------------------------------ -----------------------------------------YWDDETPLYKQLLFP---- ------------------------------------------------------------ --------------------WTGYQIN-------HAKYQTS------------------- --------------------TIAAKRIT--------------------RG---------- --------------------------------PIVQRDLKM------------------- ---------------------------STLGWA--------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---FDFDTVQTVTDELKEFTVHTQISNST-----WEF---------------------PL LDFILRNETKVNGYRLEGQVARNTHHV-FAEYDFTKE----------------------- ------------------------------------------------------------ --------------------QRETNRNFRMG-----LRTDVLVNNPDAAMFLNSPALL-- ----------------SLFGETALID-----------------------EPVVIDGGMDF RILDQS------------------------------------------------------ ------------SLTEEHLIQTSIFVPN---------------------------PRN-- -------------------PQTHLTYDFDLRFE------NATISNQKD------------ -----FSVESIF----------------------------------------------HP ILIQSN------------------------------------------IVNSLHLFIDME S---------------------------------------------------------GA SSLDHTYTLYD------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----TRYSKP--------------------QVTVSNIIAAGWK----KPSANWVMDIETP SM-------------------VYYQNYTAL------------------------------ --------------------YSRENGL------------QCFYENSQDSSFSDLLDFTEI SNLSVR------------------------------------------------------ --------------------------------------------PSAVSMYWSYLHQL-- ---------LSTNVSNSLAIEGPITEMRPRV----------------------------V PMVVRDILNKTYNKDFQIVKDLILNKFIFNVTS--------------------------- ---------SSLTLRQSANISSPVFANMSASHYIFLS--RNLFDQ---------QLTFVA EQKRL-----------------------------------NISAGLNHSLLIEGREVTLK TEGGLTA-------RTALRMNTLTSVNVTILKEDTPFDLAALH----------------- ----------------------HTEVDSPLIK----------------------FSTRSS S------NGDFHGVLNMVANHN-------------------------------------- --------------------------------------TSMTSRL--------------- -GSFDVIG >M musculus --------------------MGPRKPALRTPLLLLFLLLFLDTSVWAQDEVL--ENLSFS CPKDATRFKHLRKYVYNYEAESSSGVQGTADSRSATKINCKVELEVPQICGFIMRTNQCT LKEVYGFNPEGKALMKKTKNSEEFAAAMSRYELKLAIPEGKQIVLYPDKDEPKYILNIKR GIISALLVPPETEEDQQELFLD-TVYGNCSTQVTVNSRKGTV-PTEMSTERNLQQCDGFQ PISTSVSPLALIKGLVHPLSTL---ISSSQTCQYTLDPKRKHVSEAVCDEQHLFLPFSYK NKYGIMTRVTQKLSLEDTPKINSRFFSEGTNR---MGLAFESTKSTSSPKQ--ADAVLKT LQELKKLSISEQNAQRANLFNKLVTELRGLTGEAITSLL----------------PQLIE VSSPITLQALVQCGQPQCYTHILQWLKTEKAHPLLVDIVTYLMALIPNPSTQRLQEIFNT AKEQQSRATLYALSHAVNSYF------DVDHSRSPVLQDIAGYLLKQIDNECT---GNED HTFLILRVIGNMGRTMEQ-------VMPALKSSVLSCVRSTKPSLLIQKAALQALRKMEL EDEVR-TILFDTFVNGVAPVEKRLAAYLLLMK-NPSSSDINKIAQLLQWEQSEQVKNFVA SHIANILNSEELYVQDLKVLIKNALENSQFPTI-MDFRKFSRNYQISKSASLP-MFDPVS VKIEGNLIFDPSSYLPRESLLKTTLTVFGLASLDLFEIGLEGKGFEPTLEALFGKQGFFP DSVNKALY-WVNGRVPDGVSKVLVDHFG-------------YTTDGKHEQDMVN----GI MPIVDKLIKDLKSK------------EIPEARAYLRILGKELSFVRLQDLQVLGKLLLSG AQTLQGIPQMVVQAIREGSKNDLFLHYIFMDNAFELPTGAGLQLQVSSSG--VFTPGIKA GVRLELAN-IQAELVAKPSVSLEFVTNMGIIIPDFAKSSVQMNTNFFHESGLEARVALKA GQLKVIIPSPKRPVKLFSGSNTLHLVSTT-KTEVIPPLVENRQSWSTCKPL--FTGMNYC TTGAYSNASSTESASYYPLTGDTRYELELRPTGE-VEQYSATATYELLKEDKSLVDTLKF LVQAEGVQQSEATVLFKYNRRSRTLSSEVLIPGFDVNFGTILRVNDESAKDKNTYKLILD IQNKKITEVSLVGHLSYDKKGDGKIKGVVSIPRLQAEARSEVHTHWSSTKLLFQMDSSAT AYGSTISKRVTWRYDNEIIEFDWNTGTNVDTKKVASNFPVDLSHYPRMLHEYANGLLDHR VPQTDVTFRDMGSKLIVATNTWLQMATRGLPYPQTLQDHLNSLSELNLLKMGLSDFHIPD NLFLKTDGRVKYTMNRNKINIDIPLPLGGKSSKDLKMPESVRTPALNFKSVGFHLPSREV QVPTFTIPKTHQLQVPLLGVLDLSTNVYSNLYNWSASYTGGNTSRDHFSLQAQYRMKTDS VVDLFSYSVQGSGETTYDSKNTFTLSCDGSLHHKFLDSKFKVSHVEKFGNSPVSKGLLTF ETSSALGPQMSATVHLDSKKKQHLYVKDIKVDGQFRASSFYAQGKYGLSCERDVTTGQLS GESNMRFNSTYFQGTNQIVGMYQDGALSITSTSDLQDGIFKNTASLKYENYELTLKSDSS GQYENFAASNKLDVTFSTQSALLRSEHQANYKSLRLVTLLSGSLTSQGVELNADILGTDK INTGAHKATLKIARDGLSTSATTNLKYSPLLLENELNAELGLSGASMKLSTNGRFKEHHA KFSLDGRAALTEVSLGSIYQAMILGADSKNIFNFKLSREGLRLSNDLMGSYAEMKLDHTH SLNIAGLSLDFFSKMDNIYSGDKFYKQNFNLQLQPYSFITTLSNDLRYGALDLTNNGRFR LEPLKLNVGGNFKGTYQNNELKHIYTISYTDLVVASYRADTVAKVQGVEFSHRLNADIEG LTSSVDVTTSYNSDPLHFNNVFHFSLAPFTLGIDTHTSGDGKLSFWGEHTGQLYSKFLLK AEPLALIVSHDYKGSTSHSLPYESSISTALEHTVSALLTPAEQTSTWKFKTKLNDKVYSQ DFEAYNTKDKIGVELSGR--ADLSGLYSPIKLPFFYSEPVNVLNGLEVNDAVDKPQEFTI IAVVKYDKNQDVHTINLPFFKSLPDYLERNRRGMISLLEAMRGELQRLSVDQFVRKYRAA LSRLPQQIHHYLNASDWERQVAGAKEKITSFMENYRITDNDVLIAIDSAKINFNEKLSQL ETYAIQFDQYIKDNYDPHDLKRTIAEIIDRIIEKLKILDEQYHIRVNLAKSIHNLYLFVE NVDLNQVSSSNTSWIQNVDSNYQVRIQIQEKLQQLRTQIQNIDIQQLAAEVKRQMDAIDV TMHLDQLRTAILFQRISDIIDRVKYFVMNLIEDFKVTEKINTFRVIVRELIEKYEVDQHI QVLMDKSVELAHRYSLSEPLQKLSNVLQRIEIKDYYEKLVGFIDDTVEWLKALSFKNTIE ELNRLTDMLVKKLKAFDYHQFVDKTNSKIREMTQRINAEIQALKLPQKMEALKLLVEDFK TTVSNSLERLKDTKVTVVIDWLQDILT-----QMKDHFQDTLEDVRDRIYQMDIQRELEH FLSLVNQVYSTLVTYMSDWWTLTAKNITDFAEQYSIQNWAESIKVLVEQGFIVPEMQTFL WTMPAFEVSLRALQEGNFQTPVFIVPLTDLRIPSIRINFKMLKNIKIPLRFSTPEFTLLN TFHVHSFTIDLLEIKAKIIRTIDQILSSELQWPLPEMYLRDLDVVNIPLARLTLPDFHVP EITIPEFTIPNVNLKDLHVPDLHIPEFQLPHLSHTIEIPAFGKLHSILKIQSPLFILDAN ANIQNVTTSGNKAEIVASVTAKGESQFEALNFDFQAQAQFLELNPHPPVLKESMNFSSKH VRMEHEGEIVFDGKAIEGKSDTVASLHTEKNEVEFNNGMTVKVNNQLTLDSHTKYFHKLS VPRLDFSSKASLNNEIKTLLEAGHVALTSSGTGSWNWACPNFSDEGIHSSQISFTVDGPI AFVGLSNNINGKHLRVIQKLTYESGFLNYSKFEVESKVESQHVGSSILTANGRALLKDAK AEMTGEHNANLNGKVIGTLKNSLFFSAQPFEITASTNNEGNLKVGFPLKLTGKIDFLNNY ALFLSPRAQQASWQASTRFNQYKYNQNFSAINNEHNIEASIGMNGDANLDFLNIPLTIPE INLPYTEFKTPLLKDFSIWEETGLKEFLKTTKQSFDLSVKAQYKKNSDKHSIVVPLGMFY EFILNNVNSWDRKFEKVRNNALHFLTTSYNEAKIKVDKYKTENSLNQPSGTFQNHGYTIP VVNIEVSPFAVETLASSHVIPTAISTPSVTIPGPNIMVPSYKLVLPPLELPVFHGPGNLF KFFLPDFKGFNTIDNIYIPAMGNFTYDFSFKSSVITLNTNAGLYNQSDIVAHFLSSSSFV TDALQYKLEGTSRLMRKRGLKLATAVSLTNKFVKGSHDSTISLTKKNMEASVRTTANLHA PIFSMNFKQELNGNTKSKPTVSSSIELNYDFNSSKLHSTATGGIDHKFSLESLTSYFSIE SFTKGNIKSSFLSQEYSGSVANEANVYLNSKGTRSSVRLQGASKVDGIWNVEVGENFAGE ATLQRIYTTWEHNMKNHLQVYSYFFTKGKQTCRATLELSPWTMSTLLQVHVSQLSSLLDL HHFDQEVILKANTKNQKISWKGGVQVESRVLQHNAQFSNDQEEIRLDLAGSLDGQLWDLE AIFLPVYGKSLQELLQMD-----GKRQYLQASTSLLYTKNPNGYLLSLPVQELADRFIIP GIKLN-------------------------DFSGVKIYKKLSTSPFALNLTMLPKVKFPG IDLLTQYSTPEGSSVPIFEATIPEIHLTVSQFTLPKSLPVGNTVFDLNKLANMIADVDLP SVTLPEQTIVIPPLEFSVPAGIFIPFFGELTARAGMASPLYNVTWSAGWKTKADHVETFL DSMCTSTLQFLEYALKVVETHKIEEDLLTYNIKGTLQHCDFNVEYNEDGLFKGLWDWQGE AHLDITSPALTDFHLYYKEDKTSLSASAASSTIGTVGLDSSTD-DQSVELNVYFHPQSPP EKKLSIFKTEWR--YKESDGERYIKINWEEEAASRLLGSLKSNVPKASKAIYDYANKYHL EY-------VSSELRKSLQVNAE----HARRMVDEMN--MSFQRVAR----------DTY QNLYEEMLAQKSLSIPENLKKRVLDS-IVHVTQKYHMAVMWLMDSFIHFLKFNRVQFPGY AGTYTVDELYTIVMKETKKSLSQLF----NGLGNLLSYVQNQVEKSRLINDITFKCPFFS KPCKLKDLILIFREELNILSNIGQ------QDIKFTTILSSLQGFLERVLDIIEEQIKCL KDNESTCVAD----HINMVFKIQVPYAFKSLREDIYFVLGEFNDFLQSILQEGSYKLQQV HQYMKALREEYFDPSMVGWTVKYYEIEENMVELIKTLLVSFRDVYSEYSVTAADFASKMS TQVEQFVSRDIREYLSMLTDINGKWMEKIAELSIVAKETMKSWVTAVAKIMSDYPQQFHS NLQDFSDQLSSYYEKFVGESTRLIDLSIQNYHVFLRYITELLRKLQVATANNVSPYIKLA QGELMITF >SIG 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ APOD >H sapiens -MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQEN-------------FDVNKYLGRW Y----EIEKIPTTFENGR-CI--QANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNL TEPAKLEVKFSWFMPSAPYWILATDYENYALVYSCTCIIQ-LFHVDFAWILARNPNLPPE TVDSLKNILTSNNIDVKKMTVTDQVNCP-------------------------------- ------------------------------------------------------------ -------------------------KLS-------------------------------- -- >H_glaber -MVTMLLLLSALAGLVAEAEGQAFHLGKCPTPPVQEN-------------FDVNKYLGRW Y----EIEKIPVSFEKGN-CI--QANYSVKENGNIKVLNQELRSDGTVNQIEGEATQSNI TDPAKLGVKFFQLMPSAPYWVLATDYDNYALVYSCTNIIW-LFHIDHVWILGRNRYLPPE TVTYLKDILTSNSIDIEKMTITDQVNCP-------------------------------- ------------------------------------------------------------ -------------------------DFL-------------------------------- -- >M_brandtii KMVTALLLLSALAGLFRAAEGQAFHLGKCPTPPVQEN-------------FDVNKYLGRW Y----EIEKIPVSFEKGS-CI--QANYSLMENGNIKVINQELRSDGTVNQIEGEASQSNF TEPAKLGVKFFWLMPSAPYWVLATDYENYALVYSCTTIVW-LFHVDHVWILGRNPYLPPE TVTHLKDILTSNNIDIEKMTITDQGNCP-------------------------------- ------------------------------------------------------------ -------------------------EFL-------------------------------- -- >S franciscanus ----------------------VFGFGGCPRVRVARD-------------FDLDRYFGRW F----PITKFYTLYEDGLTCV--SAEYRPGDDGSIRVINSGRTQDGDVTAIEGVAFQPNP EEGAKLQVQFLRGQTPGDYWVLDVEYDRYALVHSCSEYLRDLIYVQNTWIIARDRRMSEE DYDDAMRYLASMGINTRKLKKAEQRKCP----------------------YYRPRPSEEP ETERPRPSEEPGTDRPRPSEEPGTDRPRPSEEPGTDRPRPSEEPGTDRPRPSEGPETERP RPSEGPETE-PQPSEIPGSERPQPHRIKESERHPPHRTAETAR-HPLLSSALARNSFVSS CL >S_purpuratus ---MRVLGLLLLLGFASFSSAQVFGFGGCPRVRVARD-------------FDVDRYFGRW F----EITKFYTFYQDGLTCV--SAEYQPGDDGSIRVINSGRTQDGDVTTIEGVAFQPDP EEGAKLQVQFFRGQTPGDYWVLDVEYDSYALVHSCSEVFYGWFNIQSNWLLARDRMPSEE VIEDALRKLGEQGINVQKLKRTNQRNCEGEPPRPTEWPVTHRPRPSERPGTDRPRPSEEP ETERPRPSEEPGTDRPRPSEGPGTDRPRPSEEPETERPRPSEEPGTDRPRPSEEPETERP RPSEEPETERPRPSEEPSTDRPRPSEEPETERPRPSEEPGTDRPRPSEEPEAFRK----- -- >L variegatus -------------------YEREISSAPQPQQKPQKRKKQSKKQLAHCLYIPMFKYFHRL FCKDPNLLMLYTIIMSKHIYFHHEGEYHFPSP---QALPPKKKQEPNKQNAISIIVYTDI Q--IFLSVFHHSSQTPGEFWVLDVDYDSYALVHGCTEIFFGWFNVQNNWVLARDRRPSEE DIQDALRKLTEQGINVKKFIRADQTDCE-------------------------------- -TEPPSPTETPGTSLTRNS----------------------------------------- -------------SDYCKVNAPRVTRFSIYFIIVPS------------------------ -- >M_musculus -MVTMLMFLATLAGLFTTAKGQNFHLGKCPSPPVQEN-------------FDVKKYLGRW Y----EIEKIPASFEKGN-CI--QANYSLMENGNIEVLNKELSPDGTMNQVKGEAKQSNV SEPAKLEVQFFPLMPPAPYWILATDYENYALVYSCTTFFW-LFHVDFVWILGRNPYLPPE TITYLKDILTSNGIDIEKMTTTDQANCP-------------------------------- ------------------------------------------------------------ -------------------------DFL-------------------------------- -- >SIG ------------------------------------------------------------ -----------------------------------+------------------------ --------------------------------------+--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- APOH >H sapiens ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MISPVLI-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LFSSF LCHVAIA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GRTCPKPDDL------------ --------PFSTVVPLKTF--------YEPG---EEITYSCK------------------ ------------------PGYVSRG----------------------------------- ------------------------------------------------------GMRKFI CPLTGLWP---------------------------------------------INTLKCT --------------------PRV------------------------------------- -------------CPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNGADSAKCTEEGKW SPELPVCAPIICPPPS-----------IPTFA---------------------------- ----TLRVYKPSA-------------GNNSLYRDTAVFECLPQHAMFGNDTITCTTHGNW TK---------------------------------------------------------- LPECREVKCPFPSRPDNGFVN--------------------------------------- ------YPAKPT----------LYYKDKATFGCHDGYSLDGPEEIECTKLGNWSAM-PSC K---------------ASCKVPVKKATVVYQGERVKIQEKF----KNGMLHGDKVSFF-- -CKNKEKKCSYTEDAQCIDGTIEV--PKCFKEHSSLAFW--------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------KTDA-------------SD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------VKPC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------- >H_glaber ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MTSPVLV-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LLSGF LCHVAIA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GQTCPQPDDV------------ --------PFSTVTPLKTS--------YDPG---EQIVYFCK------------------ ------------------PGYLSQG----------------------------------- ------------------------------------------------------GMRRLT CPFTGIWP---------------------------------------------LNTLKCT --------------------PRV------------------------------------- -------------CPFAGILDNGAVRYTTFEYPNTISFACNSGYYLNGTNSAQCTEEGKW SPELPVCAPITCPPPP-----------VPKFA---------------------------- ----TLRIYKPSA-------------RNNSLYRDRAVFKCLPHHAMFGNDTIACTAHGNW TE---------------------------------------------------------- LPECREVKCPFPSRPENGFVN--------------------------------------- ------YPAKQV----------LLYKDKATYGCHDTYNLDGPEEVECTKLGNWSAQ-PSC K---------------ASCKLSVKKATVLYQGERVKLQERF----KNGMLHGDKVSFF-- -CKNKEKKCSYTEEAQCVDGTIEI--PKCFKEHSSLAFW--------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------KTDA-------------WD--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------IMPC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------- >M_brandtii ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MISPALI-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LFSSF LCHVAVA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GRTCPRPDDV------------ --------PFATVTPLRSS--------YDPG---EQIMYFCK------------------ ------------------PGYVSRG----------------------------------- ------------------------------------------------------GMRRFT CPLTGIWP---------------------------------------------INTLRCT --------------------PRV------------------------------------- -------------CPFAGILENGAVRYTTFEYPNTISFSCNNGFFLNGTKSAQCTEEGIW SPNLPVCSPVTCPPPP-----------TPKFA---------------------------- ----VLSAYEPLA-------------GNRSVYGKQAVFKCLPNYAMFGNDTATCTAHGNW TE---------------------------------------------------------- LPECREVKCPFPIRPDNGFVN--------------------------------------- ------YPAKEA----------LSYKDKATYGCHDTYVLDGPEEVECNKFGNWSAQ-PSC KGEEKAILEPMTSGSMASCKVSVKKATVIFEGERVKIQEKF----KNGMLHGQKVSFF-- -CKNKEKKCSYTEDAQCIDGTFEV--PSCFKERQRCALWIRKLCEPSGTGAGIMGRKNRN LYAKLLLHMLKRGVIEGPFIHRPEPGTLKTLPSYMSIYFDEPNPAQAKSSSPEGLPDWVM GELGTSEHKLNESWKLSSGDSYSLVQSPTDGHREQYTAQLQRTSHSRSPTYREDGQHVTQ KSCEVHLKKSAVSLDDSDIEARLNSWNLGIENPRYLRQKPIPVSLMTPKFSLRKSSSFHE DHLLSRMHEKELDMKTKMIEAKCHEEKLKLQQKHDADVQKILERKNSEIDELKILYKTKQ NETEETVRKLEKKVQTLIRDCQVIRETKENQISELKKMCEQSTEFLNNDWEKKLHNAVAE MEREKFDLQKRHTESIQELLEDTNARLRRMEGEYTAQTQATASPFPLPAVVRHSSLFSMC PASLMCAGTTTCVQAIVAAFRALPPCPLKNSNLVFRVLPLSSQYGNRDSVPKNQMVKELE SRVQQLTGEAENSNLQKQKLIQEKLELERCYQITCSELQEVKARRNSLHKEKD-HLMNDY EQSVKLLQNKYEADINLLKKEHTLSVSKASGTIKELEQNVCQLKLQLQESELQRKQQLQD QENEFQMEKSNLKRTYEKKVHDLQSELDKEKEDTQKKIYKFEEALKSVSPIPYVSDVFIL TECMILTIQHLDSRCNLVRSRQFGTGKPGLTQSVQKLKTWKVTMMKVGRAAEVLSSYADA KRRTAQMHSEKRRSYEKCGQSVEKLRLFRPHWRETLTESSHLYSLIGSCSLPLLTTTFPI MVSPFVTVNAGMPLSYSFFYPLLLILQLTLTSFSYILTPREKEEQLARVTEVQRLQAQQA DAALEEFKRQVELNSEKVYAEMKDQMEKVEADLTRSRSLREKQSKEFLWQMEDVKQRYEQ QIVELKLEHEQEKTHLLQQHNAEKDSLVRDHERDIENLEKQLRAANMEHENQIQEFKKRD SQVIADMEAQVHKLREELINVNTQRKQQLVELGLLREEEKQRAARDHEATVSKLKAESEK MKIELRKTHAAETEMTLEKANCRLKQIEKEYTQKLAKSLQTISELQTAISALKEESSRQQ LAAERRLQDVTQKFEDEKKQLIRDNDRAIKALRDELEN------------RSNQVRCAEK KLQHRDLEAQEQITY---IRQEYETKFKGLMPASLRQELEDTISSLKSQVNFLQKRASIL Q-------------------EELTTYQGRRYGRDQNAC---------------------- ------- >S franciscanus SGYEGVDCEIEIDECASNPCQNGATCVDEVDGYTCTCLSGYEGTNCEIEIDECASNPCQN GATCVDVIDGYSCSCAPGFEGDNCEIDIDECASNPCENGATCIDGVNGYTCDCLPGFEGT NC-EIDINEC-----------ASNPCQNGATCIDGVNGY----SCSCLPGYEGDTCEID- -IDECASNPCQNGATCVDGVNGYTCE--CAPGFEGVF---------CEIDIDECSSSPCQ NGATCIDLVN---------GYTCSCLPGFE-GQKVLQGARANSTQAVFLLTDGLSNGPNP VPVAVSLKDDGVEVFSFGIRDGYIPELLQMASEKKDEHCYILDSFAEFEALARRALHEDL RMGEFIEETPEKCSSRCLGENHCCDVMASCRCGTHTGSYDCVCPAGFYG----------- -----------SGLRGK-CTCVP--GFEGINCEIEIDECASDPCQNGATCIDRINGYTCD CLPGFEGDHCEIDIDEC-VIHCPLLQRPENGEFVECSNVVNGACAIRCNRGYEVTGSSIR LCFSNGTWSGEGFDCRVKTCEVLIAPLNGSLQCTSDDYAFGTVCSATCDTGFKLIGSHSR RCLPIAHWDGLPVHCRAIQCPTLPPIPHGYMTPSHCSTQRQDYGNM-CKI---ACTQGFY RSGPRKKE------CMANGSWNNKFDPSQACIDYISPSLECPTAISTVTSPHQDRVVLEW DVPRPTDNSGEMPLLHAIPNVHPPWTFPLGQWNITYSATDQSGNIAQCVFSVIVEDKEPP SIR---------RCRSPSTFITSQKEHRVTWEEPLFSDNSGGDITVTRSHDPGSVFLFGT TLVEYLATEAALTTKSYFIYIMFQRNLCQKPRDPVGGSAICFHTTQGMNCSVTCGPGYAM STRPRKLYFCALNGTWYPDGKVPWDDCSETHHAKNVLQPMTFLYETSDCDTAFARNIERI LATNLEEINIDECASSPCQNGATCVDLINGYDPIPFLRGATSSLQQTSPGADSRLALQGA GEVSVTAHRLNILQSPNLFVNILVTASASPNETATLASGTEQTYQMVVEVAASVPEQIQS NFDNGTIVTGTNRSSERTFQVNRITVYRENIQPVCSHCEINIDECASNPCVQCIPGTYFD IVTLSCEYCEIGTYQNQIGQLSCLHCPNGTSTVNTKSTSLASCKAYCEPGSKSSTGVELC EL----CPLNTYQPNRGSTQCLECPRRRHTPSHGAWKLSDD-----EAYCPRGKTSINGL APCLPCPAGTFKMSQRSSYCLLCPEDYPLSNP-SIPITYC-SSANCQCPAGYTGTLCEID IDECASNPCQNGATCVDLINGYECQCAPGFTGTNCEIDIDECASNPCQNGATCVDLINGY TCQCPPGFTGTNCEIDIDECASNPCQNGATCVDLINGYTCQCPPGFTGTNCEIDIDECAS NPCQNGATCVDLINGYTCQCAPGFTGTNCEIDIDECASNPCQNGATCVDLINGYTCQCPP GFTGTNCEINIDECASNPCQNGATCVDLINGYTCSCPPGFTGVHCETEINECASMPCQNG GICEDQVLESDFPHQTAVTISFWMFTDNTGNSGTVFSYAVSDSSDNALTVTDYSGFVLKV NEESIYSDISARDANWHYISVTWTSETGAWAFYLDGSEAASGTGLSTGTFVKGRGMFIVG QEQDTYNGSYTHKESFIGEITYLTVWDRVLGAAEIYDLGRTCHKPSDVIIAWPDFLSGME GQIEKRNNTFCKGCPRPNAPEAGFVKGYQPSRPLTSVTYHCQLGFELPRHEVTRAECQIS GEWSPGDRAYCDIINCGYPGHLKHGYVIGRMYLYGDQVFYTCVENFTLVGPLARECMETG YWSGFTPECGVVFCREPPHVSNAVVFSSEGERPVHMAFPRQSATYQCARGYRLIGLPNVT CQIDGEWTAPPTCRIVTCPPLTSSPNSMLITTNGSVFSSIAEFRCITGYRMTGVNVLQCQ ETGRWDNAEPLCTILSCGHPPNVPLTTSTYDRVTYGSSVWYTCNEGYEADRTVIHCGGNG LWEPSLPECRRIQCPMPPAVANGSMIGGDFGFNATVIYDCDRGYTIAGNREISCMSNGQW SSSPPVCQAVSCGKPPKMDNHQLAADQSTEFTYGMTVEYTCPTGYLFHSDSPELTCGADG RWVGTLSDCIPVSCGPPNDILNSKIQGQDYTYNQTVVYACKTGFILSGVSVITCLASGQW TESSLRCDIVECGEPPALLHAVASYRRLFNESVTYTCQSGYVTRNAPHLKCLGNGSWSVV SQVCKPISCGPLSLPLHGEVTTTNITLQGIARYSCWHGYTLAGSSTRKCSESGSWSVSSQ ECKPISCGPLSLPLHGEVTTTNITLDGIARYSCNHGYLLIRSRTRTCSESGEWSGSTPEC Q--------------LVECGSPPLAENAYFLGNNFTFNNTLIYFCADGFIFGDDVVSMET TCQADGRWSEEEIRCEAVSCGMPVTPPQGVIVGTNFSYL--------------------- -----------------------------------------------NSVQFMCIPGYVI TGSESATCTSNGTWS-HLDTRCKPLDCGSPPDINNAEFELNTSTYGSTVAYQCDVGYMAA SELMIKCDETGV-------------WSGNVTNTSCQPVPCLEIPLVYNGSIE--GNIRVI YGDIVRARCWTGYTIAGESVRKCLGNGS-----WSVVSQVCKPISCGPLSLPLHGEVTTT NITLDGIARYSCNHGYLIIGSSTRKCSESGEWSGSSPECQP----ISCGPLSLPLHGEVT TTNITLDGIARYSCNHGYLLIGSSTRTCSESGEWSGSTPECQPISCLIPILPTHGIAITI NIRYLDIARYKCEPGYRLIESARRRCQASGEWSGYEPKCQPIECSVEEAFPLGIVIRNYI VFYLDKVRYRCWTGYTIAGESVRKCLGNGSWSVVSQVCKPISCGPLSLPLHGEVTTTNIT LEGIARYSCNHGYLLIGSRTRTCSESGEWSGSTPECQPIECPSPQRIRHGTLQMNTQVP- -----------IYRSSVTYRCWTGYTIAGESVRKCLGNGSWNVVSQVCKPISCGPLSLPL HGEVTTTNITLSGIARYRCWTGYTIAGESVRKC-------------LGNGSWSGSSQECQ PISCGPLSLPLHGEVTTTNITLDGIARYSCNHGYLLIESRTRTCSESGEWSGSTPECQPI TCHQPDDVEHGIIINLGNMQLLDEIQYRCWTGYTIAGESVRKCLGNGSWSVVSQVCKPIS CGPLSLPLHGEVTTTNITLNGIARYSCWHGYTIAGSSVRKCSESGSWSGSSPECQPISCG PLS----LPLHGEVTTTNITLQGIARYSCNHGYLLIGSRTRTCSESGEWSGSTPECQPNP CQALPRIPHAIYPADKTRFIYGDIVQARCWTGYTIAGESVRKCLGNGSWSVVSQVCKPIS CGPLSLPLHGEVTTTNITLGEIARYSCNHGYLLIGSRTRTCSESGEWSGSLPECQPITCE DLAAPKNASYQSTSVSFGSAVVIQCDNGFKLVGTSSIQCQSAGQWSHPPPRCEAIECLIP PAIDHGIAIFISNSYGDSVTFKCHPGYYLVGSSSIRCQAQGTWSQYPPKCTAFGSLASLE RPVCVLPCLHGGKCVGPYSCECPYGFTGSRCEHRCEICVNEC-------QSHPCLIGATC VC----- >S_purpuratus -------------------MARYYYLISVLLPFLCFSLSFVRGL------------PARA PDLKLLLASGINIS----FPDEHRQLEF---ADYPQADGLVSQPRPADDPLP-LPLIQSL SYLDIDLEQSHHELYEALWRNADVPMDTSSATKIDVLGYLLKKQVEKLRRVSNGQVELVF LVDSSASVGIENFFNELKFVKKLLADFTVAPDATRVAIITFSSKHRVELNVNQLDNSIAG KHHHKCALLNEDLPKITYVGGGTYTKGAFELAKKVLQGARANSTQAVFLLTDGLSNGPNP VPVAVSLKDDGVEVFSFGIRDGYIPELLQMASEKKDEHCYILDSFAEFEALARRALHEDL RMGEFIEETPEKCSSRCLGENHCCDAMASCRCGTHTGSYDCVCPAGFYG----------- -----------SGLRGK-CTPCPIGSYKRDALPGGINTCLPCPVQNHVSPFNNTSPNMCV CKDGYRWD---IATHRCKVIHCPLLQRPESGEFVECSNVVNGACAIRCNRGYEVTGSSIR LCFSNGTWSGEGFDCRVKTCEVLTAPLNGSLQCTSDDYAFGTVCAATCDTGFKLIGSHSR RCLPIAHWDGLPVHCRSIQCPTLPPIPHGFMTPSHCSTQRQDYGNI-CKI---ACTQGFY RRGPRKKE------CMANGSWNNKFDPSQACMDYIAPSLECPTAISTVTSPHQDRVVLEW DIPRPTDNSGEMPLLRAIPNVHPPWTFPLGQWNITYSATDQAGNIAQCVFSVTVEDREPP SIR---------RCRSPSTFITSQREHRVTWEEPLFSDNSGGDITVIRSHDPGSVFLLGT TLVEYLATDEAGNTRSCVIYVDVQQNLCQKPRDPVGGSAICFHTTQGMNCSVTCGPGYAM STRPRKLYFCALNGTWYPDGKVPWDDCSETHHAKNVLQPMTFLYETSDCDTVFARNIERI LATNLEEPIRNYCGENVQCELSSVKANCEDRDPIPFLQGAPSSLQQTSPGADSRLALQGA GEVSVTAHRLNILQSPNLFVNIVVNASASPNETAALTSPTDQTYQMVVEVAASVPEQIQS NFDNGTIMTNSNRSSERTFQVNRITVYREDIQPVCSAGAVRRGEGEGAKCVQCIPGTYFD IVTSSCEYCGIGTYQNQIGQLSCLHCPNGTSTVNTKSTSLADCKAHCEPGSKSLTGLELC EL----CQLNTYQPNRGSTQCVECPRRRHTPSHGARKLSDC-----KAYCPRGKTSVNGL TPCLPCPAGTFKISQRSSYCLLCPEDYPLSNPGSITITYCRNSANERSPAGRMMSLRSLP FSECFSSPCRNGGSCESSPGGYVCTCPAGYTGPRCETDINECETAMCMNNGSCRDLIDGY MCHCPRGFTGRYCSEDVDECRTNPCHNGATCIDGPQYYECVCPDGYTGRNCEEDVDDCAL DPCYNFGTCTDFIGGFQCTCQAGYLGDLCEMEVDECLSYPCDNNATCKDMVNEFRCECLA GFSGTLCEINIDECATTPCLNGATCKDLIAGIECVCMPGYTGVFCEEEMTWDFNMVFDRG GIDDFVVLERDFPTLTAVTISFWMLTDNTGNSGTVFSYAVSDSSDNALTVTDYSGFVLKV NEETIVSDITANDGRWHHIVATWDSNGGTYTMYKDGVQQANGTGLSNGMSIPGGGTLILG QDQDTLGGGFTHLESFIGEITYLTVWERALGAAEIYDLGRTCQKPSDVIMAWPDFLSGME GQIEKRNNTFCQGCPYPTAPEAGFVKGYQPSRPLTSVTYHCQLGFELPRNEVTRAECQVS GEWNPGDRAYCDRINCGYPGHLKHGYVIGRMYLYGDQVFYTCVENFTLVGPLARECMETG YWSGFTPECKYVFCGEPPHVPNAVVFSSEGERPVHMAFPRQSATYQCARGYHLIGLPNVT CQIDGEWTAPPTCRIVSCPPLTSSPNSMLITTNGTVFSSIAEFRCITGYRMTGMNVLQCQ ETGRWDNAEPLCKILSCGHPPNVPLATSTYDGLTYGSSVWYTCNEGYEADRTVIHCGGNG VWEPSLPECRRIQCSMPPAVANGSMIGGDFGFNATVIYDCDRGYTVAGNREISCMSNGQW SSSPPVCQAVSCGEPPKMNNHQLVADQSPEFTYGITVEYTCPSGYLFDSDSTELTCGAGG HWVGTLSDCIPVSCGPPNDIPNSNIKGQDYTYNQTLVYTCKTGFILSGVSVITCLASGQW TESSVRCDIVECGEPPAVPHAVASHGRLYNESVTYACQAGYVTRNAPHLRCSAEGQWWGD LPVCEPITCEVPLAPDHGFIVGTNWSFQSEIVMECDLGYRLHGEATRQCQSSGQWSNTSA ECILIFCPEPPVIRHGNAHFDNLIYGSSVTYKCHEGYILEGESSRNCSAQGEWTQEPPSC K--------------LLECGSPPLVENAYFLGDNFTFNNTLIYFCDDGFIFGGDVVSMET TCQADGRWSEEEIRCEAISCGMPVTPPQGFILGTNFSYL--------------------- -----------------------------------------------NSVQFVCNPGYVL TGSKSATCTSNGTWS-HSDTRCKPLDCGSPSDVNNAEFELNTSTYGSTVAYQCDVGYKAI SKLMIECDETGV-------------WSGNVTNTSCQPVPCLEIPLVYNGLIE--GEGLFV YGDIVRAHCDEGFKYQTLQEMRCSENGI-----WDPANITCVPITCPPVLPPDNGFIAVD SNSYGEVMVFDCNEGFSIDGNDTLLCEEDGEWNGDMPQCLP----IICEDLAIPQNGSVQ STGVSFGSQVVYTCDDGFELVGTSVTECAGQGVWSHPPPVCTLIECPMPINPAHGIAIFL NNRYLDDVSFGCEPGYHLVGLARRRCQANGTWSGYEPKCRPIECRVEEAFPLGIVIRNHT VFNGDKVLYSCNPGYMIAGQSFRICGNDGILSGQQPTCIRVTCGPPPNLLLGNVTLPSDR YESNATYSCSLGFTLDGPSSRQCLSNGSWSFAHQDCRVIECPSPPPIRHGTLQMNTKIP- -----------IYRSSVTYTCDVGYAVKGESMLTCDEHGSWSNTMPSCELVSCGQPPFLE KGIVSFDVTTFSSQATYRCWTGYIIAGESVRTC-------------LANGSWSLVSQVCK PISCGPLSLPLHGEVTNTNITLDGIASYSCDHGYVLIGSRTRTCSVSGEWSGSTPECQPI TCQQPDDVEHGIIINLGNMQLLDEIQYRCNEGYKMRGEDRRICQADQTWSGSLPACRPIS CDTPPIVINGVRSYKAITFNSTAVYDCHSGYTMHGVQVVRCTSDGSWLPYPPQCRPVKCG PLT----NPHNGKVILESKVYQSQVHYICHDGYSTNQPRSRTCLANGTWSEKEPQCSPNP CQALPRIPHVIYPADKTRFVVGDFVQLECENGFQPSSEGMAECLPDQTWSLTEFSCDPLE CLPPESPENGHAEYRTLFFGSIVTYTCNAGYTLLGRATSSCNANQTWSNPLPLCHLVTCP DLPASENMVYLSTSNAVGDAVTISCSNGFKLVGTSRILCTSEGTWSHSLPRCEADGCLPP PVIDNGRMFGESFSPGDVLSFRCNRGFYRVGSSSIRCMSDNTWNDSIPKCIAFGSLASLE RPVCVLPCLHGGKCVGPYSCECPYGFTGSRCEH--VLCTTRCIGGARCKTRHP-----NC RT----- >L variegatus -------------------MMGMYYLINILLLFMCFEVSYERRL------------PVRA PDLKLLLDSGINVS----FPDEHRQLDF---ADYPQADGLASQPRPADDPLP-LPLLQSL SYLNIDLERSHHELYEALWRNADVPMDTTSATKIDVLGYLLKKQVEKLRRVSNGQVELVF LVDSSASVGIENFFNELKFVKKLLADFTVAPDATRVAIITFSSKHRVELNVNQLDNSIPG KHHHKCALLNEDLPMITYVGGGTYTKGAFELAQKILQGARGNSTQAVFLLTDGLSNGPNP VPVAASLKEDGVEVFTFGIRDGYIPELLEMASEKKDEHCYILDSFAEFEALARRALHE-- ------------ASNPCQNGATCVDGI---------NGYLCICLPGYEGDNCEIEIDECE SNPCQNGATCDDGINGYFCCCCPIGSYKREALPGGINTCLPCPDQNHVSPLNNTSPNMCV CKDGYRWDI--ATINEC-VIHCPLLQRPENGEFVECSNVVNGACAIRCNRGYEVTGSSIR LCFSNGSWSGEDFDIRVKTCEVLTAPLNGSLQCTSDDHAFGTVCAATCDTGFKLIGSQSR RCLPIAHWDGLPVHCRGMNGATCDDIINGY-----CCCCLPGYEGINCEINIDECSSNPC QNGATCIDGINGYCCCCLPGYE-----GVTCTDYMPPSLECPSDINTVTSPHMDRVVLEW EVPRPIDNSGEMPLLHALPNVYPPWTFPLGHWNITYSATDQSGNIAQCVFSVIVEGRDCQ NGATCIDLINGYRCNCLPGF--EGRNCEINIDECLSNPCLNGA-----TCDDGINGYECC CLPGFDGVCCEINIDEC--YLLISENLCEKPRDPVGGSAICFHTTQGMNCSVTCGPGYAM STRPRNQYFCALNGTWYPDGKVPWDDCAETHHANNVLQPMTFLYETSKCDSVFARNMEKL LATNLEEPVRDECSSNPCQNGATCIDLINGYDPIRFLHGASSSLQQSGSGSDSRLALQGG GEVSLTAQRLQILQSPNLFVNIVVNGDECSSSPCQNGATCEQTYQMVVQVAASVPGQIQS NLANGTIVSSTNRTLDRSFQIDRITVYREDIQPECINCEINIDECSSSPCVQCIPGTYFD MMTSSCEYCEIGQYQNLIGQLTCIHCPNGTSTVSTKSTSLADCK-----GPPGFEGVH-C EINIDECASN---PCLNGATCIDGINGYICICLPGFEGVNCEINIDEAYCPRGKTSANGL TPCLPCPAGTFKMSQRSSYCLLCPEDYPLSNPGSITIIYCRNSYKCQCPAGFNGTLCEID IDECSSNPCQNGATCIDLINGYTCECLPGFEGTNCETDIDECSSNPCQNGATCIDLINGY TCECAPGFTGTNCEIDIDECSSNPCQNGATCVDLINGYTCQCAPGFTGTNCEIDIDECSS NPCQNGATCVDLINGYTCQCAPGFTGTNCEIDIDECSSNPCQNGATCIDLINGYTCQCLP GFEGTNCEINIDECASNPCLNGATCVDLINGYTCQCAPGYEGTNCETEINECASMPCQNG GVDDYVLLEHDFPTLTAVTISFWMYTDNEGNYGTVFSYAVSDTIDNALTIKDYTGFVLSV NEENIVSDITGNDGRWHHIVATWDSNGGTYTMYKDGVLEANGTGLASGTSVPGGGKLIIG QDQDALGGGFAHIESFIGEITFLTVWDRVLGADEIYELGRTCEKPSDVIIAWPDFLSGIE GQIKQVNNTFCQGCPRPTMPEMGFVKGYLPGRPLTSVTYHCNLGFEMPRHEVRRAECQIS GEWSPGDRAYCDIINCGYPGHLKHGYVIGRMYLYGDQVFYTCVENFTLVGPLTRQCMENG YWSAFTPQCRIIYCREPQQVPNAVIFSSEGARPVHMAFPHQNATYQCAQGYRLIGSPNVT CQIDGEWTAPPTCRIVTCPPLASPLNSMLITTNGSVFTSIAEYRCITGYRMTGANVLQCQ ETGSWDNPIPTCTIMSCGHPPDVSHATSSYEGVTYGNSVVYACHDGYEADWTVSHCGANG QWEPSPPECRRIQCSMPPAIANGSMTGGDYRFNSSVTYDCDHGYIINGDREISCMSNGQW SSSPPFCQAVPCGKPPEMDIHQPLVDQVTEFTYGMTVRYTCKIGYLFASDIIELTCGADG EWIGTLSDCDPISCGAPNEIPNSSFEGEDYSFNHTVTYYCKTGFIRSGDPVVRCLASGQW MESSVRCDIIQCEDPPAVLHAVVSHERLYSESVTYSCDPGYKIAGQAFRICGNQGIWAGE LPTCIPVTCPPPPDLDNGFISVKNDSYGSSVTYSCNPGYTLQGEALRQCLSDGSWSGISP TCIPVKCPPPPTPQNGSVTLDNLSYGSQATYSCDDGYTLSGQASRQCSANGSWSQEPPDC T--------------PIECGNPPLIEHGIYIGKNFTFNSTLVYFCADGFIFGEDVVSMET TCQSDGRWSEEVIECEAVTCGMPPIPPHSIIIGSNFSYL--------------------- -----------------------------------------------DSVQYECELGFVP SGEGMVECLPDGSWS-TVEPSCDPLECPRPEAPENGHAEYRNLSFGSIVTYSCDTGYTLS GQAMAQCDSSGQ-------------WS-EINIDECCSHPCQNGATCCD-MINGYGEGKFV YGSIVRYDCHQGFKLPGVHKMRCSQYGI-----WDPLNITCIPITCPPVLPMDNGFISVK SNSYGESVTFSCEEGFSLVGNARLLCEEEGQWSGDLPRCIP----VTCDPPLPPDNGFIQ SKSVSYGSSVVYACNNGFELVGAAFLRCTGDGQWSGDLPRCIPVTCGPPPTPQNGNVILP NDSYGSQVTYQCDLGYELVGPASRQCLSNGTWSGSQPDCIPIPCAAPEAIPHGIYIQHKT VQYGSQIEYACDPGYKIAGQSRRICQADGIWSGPQPECIPVSCPPPPMPAHGIAILINDK YESEATYQCSPGYRLDGPTSRQCLSNGSWSFSNHNCRVIECPSPQPIEHGTFAMNTQVP- -----------IYKSKLTYTCDVGYTVRGDHILTCDEQGSWSNPLPSCQPVSCPQPPILY HGIVSFINTSYLSKVTYSCNPGYTLAGAAFRIC-------------TSNGSWSGEQPTCI PVSCGPPPDPLNGNVTLPNDKYESNATYSCSLGYTLDGPRSRQCLSNGSWSGSTPDCQPI SCAHPEDIEHGIIISHSNFVILDKVQYSCEPGYKISGQAMRICDPDQSWSGSLPSCIPVS CPPPPALENGHVSYRADSYGSIVTYSCDTGYTLAGQAFRICTSNGSWSGEQPTCIPVSCG PPP----DPAHGNVTLPNDKYESNATYSCSLGYTLVGPRSRQCLSNGTWSGSTPDCQPIP CAALPLIPHAIYPPDKTNFVVGDFVQLECENGFQPSAEGMVECLPQQSWSTVEPSCIPIE CPPPPAPDNGIASYKATSYGSSVTYDCDTGYTLVGQAMLSCDENGQWSGDLPRCEPVSCD PLPNPQHGFVISNSNSYGSQVVYACDNGYELVGARLRTCTANGSWSGNPPRCQPVSCGPL PLPQHGIVISESNSYGSQVFYSCNDGYELVGSRSRTCQLNGTWSGSTPRCIAFGSIAALE RPVCVLPCLHGGKCVGPYTCQCPYGFTGSRCSISCHLSATII-------SSLP-----RC SCHYLYH >M_musculus ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MVSPVLA-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LFSAF LCHVAIA----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------GRICPKPDDL------------ --------PFATVVPLKTS--------YDPG---EQIVYSCK------------------ ------------------PGYVSRG----------------------------------- ------------------------------------------------------GMRRFT CPLTGMWP---------------------------------------------INTLRCV --------------------PRV------------------------------------- -------------CPFAGILENGIVRYTSFEYPKNISFACNPGFFLNGTSSSKCTEEGKW SPDIPACARITCPPPP-----------VPKFA---------------------------- ----LLKDYRPSA-------------GNNSLYQDTVVFKCLPHFAMIGNDTVMCTEQGNW TR---------------------------------------------------------- LPECLEVKCPFPPRPENGYVN--------------------------------------- ------YPAKPV----------LLYKDKATFGCHETYKLDGPEEAECTKTGTWSFL-PTC R---------------ESCKLPVKKATVLYQGMRVKIQEQF----KNGMMHGDKIHFY-- -CKNKEKKCSYTVEAHCRDGTIEI--PSCFKEHSSLAFW--------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------KTDA-------------SE--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LTPC---------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------- >SIG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----+------------------------------------------------------- ---------------------------------------------------+-------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ APOO >H sapiens --MFKVIQRSVGPASLSLLTFKVYAAPKKD------SPPKNSVKVDELSLYSVPE-GQSK YVEEARSQLEESISQLRHYCEPYTTWCQETYSQTKPKMQSLVQWGLDSYDYLQNAPPGFF PRLGVIGFAGLIGLLLAR-GSKIKKLVYPPGFMGLAASLYYPQQAIVFAQVSGERLYDWG LRGYIVIEDLWKENFQK-----------PGNVKNS------------------------- -------------PGTK------------------- >H glaber --MFKVLQKSVGLASLSLLTFRVYAAPKKD------WPRKNSMKIDELSLYSVPE-GQPK YMEEPRTQLEESISQLRHHCEPYTSWCQETYSQTKPKMQSLVQWGLDGYEYLQNAPPGFF PRLGVIGFAGLVGLVFTR-GSKIKKLVYPPVFMGLAASIYYPQQAITFVQVSGEKLYDWG LRGYIVVEDLWKENFQK-----------PGNVKSS------------------------- -------------PGNK------------------- >M_brandtii MAAVRMRKLTIMPAGLIFASISVHAAKEEE-------SKKQLMKPEQLPIYASPP-LQSK YVEEQPGNLQMGFASIRTTTGRYIGWCKGVYVFVKNGIMDTVQFGKDAYVYLKDPPRDFL PKIGVITVSGLAGLVSARKGSRFKKIAYPLGLATLGATVCYPVQSVIIAKVTGKKAYATS QKMYEAVKSLWTKDNKKESLPEPKEKIKPENSAETEIPAKTAHDPKHSVGLPTELRSEMK TKSEFTSGATQFMPDPKLMDHGQSHPEDVDMYSTRS >S franciscanus IVLFYVIHLRL--------------------------PSYQQKKPKDLPLYSEPKQTEYQ LIMEGPSALREMVGTVREQVWRFSDTFNVSNEYTGCFKDPL---GHSVVKFIK-TEEGFY PRAGVISIAGLAGLVLARRGGFIRKVLYSGGLMTATASLCYPYQAVRI----GKAEIEWV KTK---AADLYKGDTAT-----------PAVSLDINIFEKALFWPG----------IICP PIQNHIESSAQIQPGLYLMQYSALCGAHKAQ----- >S_purpuratus MSRQVFVALRYGSMPMLGLGLLQVKAGENTVGGEDMTPVTCLVKPKDLPVYSEPEQTEYQ LIPEGPSALRDMVGTVREQIWRFSDTFNGAISFTQRTYKSAEQTTQSVVKFIK-TEEGFY PRAGVISIAGLAGLVLARKGGFFRKVLYSGGLMTATASLCYPYQAVRI----GKAEIEWV QTK---AADLYKGATST-----------PAVEKVAATEAKTEEDTK----------AETS SSEESAEKVEESKSGTSLEDHGQSKPEDKDMYTTRS >L variegatus -KIQVFVALRYGSMPM----------------------------------LGL------- -----------GLLQVRAGESPGELYFEGVIQFIK-------------------TEEGFY PRAGVISIAGLAGLVLARKGGFIRKVVYSGGLMTATASLCYPYQAVRI----GKAEIEWV KTK---AADLYKGDTSS-----------PAVSLEIELFDAL------------------- -------------QALK------------------- >M musculus --MFKVIQRSVGPASLSLLTFRVYAAPKKD------SPHKSYMKIDELSLYSVPE-GQSK YVEEPRTQLEENISQLRHHCEPYTSFCQEIYSHTKPKVDHFVQWGVDNYNYLQNAPPGFF PRLGVIGFAGFVGLLFAR-GSKIKKLVYPPFFMGLGASVYYPQQAITIAQITGEKLYDWG LRGYIVIEDLWKQNFQK-----------PGNVKNS------------------------- -------------PGNK------------------- APP >H sapiens ----------MLPGLALLLL-------------AAWTARA-----LEVPTDGNAGLLA-- --EPQIAMF-------CGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQ ITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERM DVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGID-KFRGVEFVCCPLAEESDNVDSAD AEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEE PYEEATERTTSIA-TTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK-CAP FFYGGCGGNRNNFDTEEYCM--AVCGSAMSQSLLKTTQEPLARDPVKLPTTAASTPDAVD KYLETPG--DENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKAD------- KKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRP RHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMT-HLRVIYERMNQSLS LLYNVPAVAEEIQDEVD-------------ELLQKEQNYSDD------------------ ------------------------------------------------VLANMISEPRIS YGNDALMPSLTETK------TTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEP-- -----VDARPAA---DRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFF AEDVGSNKGAI------------------IGLMVGGVVIATVIVITLVMLKKK-QYTSIH HGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN >M_brandtii MLKAGLIHNGELARIELFLLWLPSPAFPGVSPPGPWIAITNPNLFFQVPTDGNAGLLA-- --EPQVAMF-------CGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQ ITNVVEANQPVTIQNWCKRGRKQCKTHGHMVIPYRCLVGEFVSDALLVPDKCKFLHQERM DVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGID-KFRGVEFVCCPLAEESDNVDSAD AEEDDSDVWWGGADADYADGSEDKVVEVTEEEEVADVEEEEAEDDEDDEDGEEVEEDTEE PYEEATERTTSIATTTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK-CAP FFYGGCGGNRNNFDTEEYCM--AVCGSVMSQSLLKTTQEPLPRDPVKLPTTAASTPDAVD KYLETPG--DENEHAHFQKAKERLEAKHRERMSQVMREWEEAEHQAKNLPKAD------- KKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRP RHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMT-HLRVIYERMNQSLS LLYNVPAVAEEIQDEVD-------------ELLQKEQNYSDD------------------ ------------------------------------------------VLANMISEPRIS YGNDALMPSLTETK------TTVELLPVNGDFSLDELQPWHPFGVDSVPANTENEVEP-- -----VDARPAA---DRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFF AEDVGSNKGAIIGLMVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKK-QYTSIH HGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN >H_glaber ----------MLPGLSQLLI-------------LCASSRA-----TEVPTDGNAGLLA-- --EPQIAMF-------CGKLNMHMNVQNGKWEPDPSGTKTCIGSKEGILQYCQEVYPELQ ITNVVEANQPVTIQNWCKRSRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERM DVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGID-KFRGVEFVCCPLAEESDNIDSAD AEEDDSDVWWGGADTDYADGSEDKVVEVTEEEEVADVEEEEADDDEDVEDGDEVEEEPEE PYEEATEKTTSIA-TTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK-CAP FFYGGCGGNRNNFDTEEYCM--AVCGSVMSQSLLKTTGEPVSQDLVKLPTTAASTPDAVD KYLETPG--DENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKAD------- KKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRP RHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMT-HLRVIYERMNQSLS LLYNVPAVAEEIQDEVD-------------ELLQKEQNYSDD------------------ ------------------------------------------------VLANMISEPRIS YGNDALMPSLTETK------TTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEP-- -----VDARPAA---DRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVRHQKLVFF AEDVGSNKGAI------------------IGLMVGGVVIATVIVITLVMLKKK-QYTSIH HGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN >S franciscanus ----MENFIKMATNMAFYLV-------------LLFAI-------LSVASAGYLQALAAG AFDPSSSRFELRVAVRKGFFNKYADILSGQWLTDTSAEYTSDATE--VLNYCKTRKYRYC RPKYAHPIKP-YISRFPSCATDHQ-QHPHPYLFKIPKVGPFESDALMVYNVCKFYHKHDE NTCREPEYWKGVS--------LLISFSFRWIPRVIYLQYKRVIFPIYQISC--------- -----------------------SYIMSYRGASGTQGQKKELEAS--------------- ------------------------------------------CYWSQMYLKAKIPK-LRI -----CACQSPPISASCYCYIPAVAKPQITSNILD--------DP--------------- -YFSEQGLAGRVEKKEYSNAKGRLSSNQKAKMARVMQQWQEAQEHYETLKAKDPQAAEQM RKEMTQRFEQTIGTMETENAEETEELREAHQVHIAVSLREKINASYEAYRFTVDVPKPQS KKILHSLRRYLHAIQKTRQHYITHYKHLRKTDPMKADQHKRFTLN-KLKTLDFEVAQSVD LLQNLPDLYAELKPKVSIYSSHKICIHPQRPIQHKVHKHPQQ---------------RIS QPSRKSLSPYIYSIQYKLYARIQIHIMLYRSQSSASNYSYSLFILQEYFTCRIICAPTVS KSFETKPSTMAKTSPAQTKPSPSQTKPRTSTATQTEPEPPTPSRDTEPEIEQETEIQVPA EKVQIVAGKPIESYLDDELTAPLDTEVVKPQTLIIAQKPKAKVEKSAAAARVEKQRLV-S RQDVNSIDQSSTKKIP----SLRYEPMMAFGLACGVLAVATVLVIAVLIVRRKTRRTPVN SGFTEIDPNLTVEQRHIVAMQQNGYENPTYKYFD-MQ- >S purpuratus ----MENLIKMASNMALYLV-------------LLFAI-------LSVASAGYVEALAAG AFDPSSSRFELRVAVRKGYFNKYADILSGQWLTDTSAEFTADATE--VLNYCKTKYPDTE INNIVDSSQPILIDQWCPVNGDAC-TSSAKVTYYRCLVGPFESDALMVYNVCKFYHKHDE NTCREPEYWKGVADEDCRGKKMGINSTGMLLPCQTD-KFKGVEYTCCPPP---------- -----------------------TYRPMTAGEEETEVEEEEEEAE--------------- -------------------------------AEAAAAGGETQAQVQEE-LPVQAPA-PAP --------ERDNV----------VAKPQITSNILD--------DP--------------- -YFSEQGLAGRVEKKEYSNAKGRLSSNQKAKMARVMQQWQEAQEHYETLKAKDPEAAEQM RKEMTQRFEQTIGTMETENAEETEELREAHQVHIAVSLREKINASYEAYRFTVDVPKPKS KKILHSLRRYLHAIQKARQHYITHYKHLRKTDPMKADQHKRFTLN-KLKTLDIEVAQSVD LLQNLPDLYAELKPKVD-------------ALLDSTHDTPEDAALIRATEEEEEVEEEEV MIAQAKVTEAPPAPQRTELEPVAEITEPEVADEVISQAEEEELEEVEEFLEEDTEAPTVS RSFETKPSTLAKTSPAQTKPSPSQTKPRTSTATQTEPEPPTPSRDTEPEIEQETEIQVPA ENVQIVAVKPIESYLDEELTAPLDSDVVKPQTLIIAQKPKAKVEKSAAAARMEKQRLV-G RQDVNSIDNSVTKKRM----SLRYEPMMAFGLACGVLAVATVLVIAVLIVRRKTRRTPVN SGFTEIDPNLTVEQRHIVAMQQNGYENPTYKYFD-MQ- >L variegatus ----MENFIKMASNVAFYLV-------------LLLAI-------LSVASAGYVQALAAG AFDPSSSRVELRVAVRKGYFNKYADIISGQWLTDTSAEYTSDPTE--ILNYCQQKYPNAE VNNIVDSSQPTRIDQWCPVNGDEC-TSSAKVTYYRCLVGPFESDALMVYNVCKFYHKHDE TTCREPEYWKGVSDEDCRAKKMGINSTGMLIPCKTD-KFK-------------------- ---------------------------YKREENMKCIQGHIIKESVS------------- -------------------------------CPARSKAPEIEYQIINYYIKYTRAQACSP ---------ESQIQHIRYEY--SVDEPQVKSNILD--------DP--------------- -YFSEQGLTGRVEKKEYANAKSRLSANQKAKMARVMQQWQEAQEHYETLKAKDPEAAEKM RKEMTERFEQTIGTMETENAEETEELREAHQVHIEVSLREKINASYEGYRFTVDVPKPKS CR----LREIWIAI--IIQIYLIY-----------ACEYSKYSLPINIKCQPPQICQAAS LM----DIIIQIQPS---------------QVLHRMQKKIQD------------------ -----------------------------------------------PPKNKKTRFLTVS KSTETKPSTQAKTSPAQTKPSPMQTKPRTSTATHTEPEPPTPSRVTGSEVEQETEIQVPA EKVQILAVKPIESYLDEELTAPVDTDVVKPQTLIVAQKPQAKVEKSAAAARVEKQRLV-S RQDVNS----VTKKRM----QLRYEPMMAFGLACGVLAVATVLVIAVLIVRRKTRRTPVN SGFTEIDPNLTVEQRHIVAMQQNGYENPTYKYFD-MQ- >M_musculus ----------MLPSLALLLL-------------AAWTVRA-----LEVPTDGNAGLLA-- --EPQIAMF-------CGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQ ITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERM DVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGID-KFRGVEFVCCPLAEESDSVDSAD AEEDDSDVWWGGADTDYADGGEDKVVEVAEEEEVADVEEEEADDDEDVEDGDEVEEEAEE PYEEATERTTSTA-TTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGK-CVP FFYGGCGGNRNNFDTEEYCM--AVCGSVSTQSLLKTTSEPLPQDPDKLPTTAASTPDAVD KYLETPG--DENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKAD------- KKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRP HHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMT-HLRVIYERMNQSLS LLYNVPAVAEEIQDEVD-------------ELLQKEQNYSDD------------------ ------------------------------------------------VLANMISEPRIS YGNDALMPSLTETK------TTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEP-- -----VDARPAA---DRGLTTRPGSGLTNIKTEEISEVKMDAEFGHDSGFEVRHQKLVFF AEDVGSNKGAI------------------IGLMVGGVVIATVIVITLVMLKKK-QYTSIH HGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN ATP6 >H sapiens MNENLFASFIAPTILGLPAAVLIILFPP--LLIPTSKYLINNRLITTQQWLIKLTSKQMM TMHNTKGRTWSLMLVSLIIFIATTNLLGLL-PHSF-TPTTQLSMNLAMAIPLWAGTVIMG FRSKIKNALAHFLPQGTPTPLIPMLVIIETISLLIQPMALAVRLTANITAGHLLMHLIGS ATLAMST---INLPSTLIIFTILILLTILEIAVALIQAYVFTLLVSLYLHDNT >M musculus MNENLFASFITPTMMGLPIVVAIIMFPS--ILFPSSKRLINNRLHSFQHWLIKLIIKQMM LIHTPKGRTWTLMIVSLIMFIGSTNLLGLL-PHTF-TPTTQLSMNLSMAIPLWAGAVITG FRHKLKSSLAHFLPQGTPISLIPMLIIIETISLFIQPMALAVRLTANITAGHLLMHLIGG ATLVLMN---ISPPTATITFIILLLLTILEFAVALIQAYVFTLLVSLYLHDNT >S purpuratus MTASILGQFFPETLFFIPMNVFSMAFCLSWLVFIYPVNWAPSRFQSIWLGFRSNILEMIF QNTSPNTAPWAGLIAGVFVLILLVNVLGLFPPYAFQSPTSNISLTYSLGFPLWMAINILG FYLAFNSRLSHLVPQGTPSALIPLMVWIETLSLFAQPIALGLRLAANLTAGHLLIFLLST AIWLLSSSLMISVP----ILIIFILLFVLEIGVACIQAYVFTALIHFYLQQNI >L variegatus VTPRIFGQFFPETLFFIPMNVFSMVFALSWLAFIYPTKWAPSRFQSVA-SFRENVLEMIF QNTRPSTAP-AGLITAVFVIILSVNVLGLF-P-AF-TATRHISLTYRLGFPL-MAVKILG FYLAFKRRLSHLVPQGTPNALIPLMV-IETLRLFAQPIALGLRLAANLTAGHLLIFLLST AILLSSS-PMIRIP----IFVIFVLLFVLEIGVACIQAYVFTALVHFYLQQNI >S franciscanus VTPRIFGQFFPETLFFIPMNIFSMVFALS-LIFIYPTK-APSRFQSIWLRFRENILEMIF QKTRPKTAP-AGLITGIFII-------------AF-TATRHISLTYRLGFPL-MAVKILG FYLAFNSRLSHLVPQGTPSALIPLMV-IETLSLFAQPIALGLRLAANLTAGHLLIFLLST AILLSSS-LMVSIP----IFIIFVLLFVLEIGVACIQAYVFTALVHFYLQQNI >259020178__H_glaber 109 origGI 343403917 MNENLFAPFSTPTLMGLPIIIIIMMFPS--MLLSRPNRLINNRLTSLQQWAIQMTLKQLM TMHNTKGRSWTLMLTSLILFISSTNLLGLL-PYTF-TPTTQLSMNLGMAIPLWAGTVILG FRHKTKKSLAHFLPQGTPNPLIPMLVLIETISLFIQPVALAIRLTANITAGHLLMHLISK AVLTLIS---INITTALITFTILILLTMLEFAVAMIQAYVFTLLVSLYLNDNT ATP8 >H sapiens -MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVA ITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSLAYEWLQKGLDWTE >226346498__H_glaber -MNMTISLLMNFSLASILMLIAFWLPQMDAYAEKLSPYECGFDPMGSARLPFSMKFFLIA ITFLLFDLEIALLLPLPWASQTNNLTLMLTVSLMLISVLALGLFYEWSQKGLEWDK >S franciscanus MTTIIFLFGITIAVATVFGLAAHALPRRAGDKEKNSPYECGFDPLNSARLPFSFRFFLVA ILFLLFDLEIALLFPLPAAELITNPSTLIPISLIFMIILALGLVFE-VKGGLE-AE >226346498__S_purpuratus MTTIIFLFSITIAVAVVLGLAAHALPNRTSDSEKSSPYECGFDPLNSARLPFSFRFFLVA ILFLLFDLEIALLFPLPAASLITPPSTLIPISMVFMVILTLGLVFEWINGGLEWAE >L variegatus MTPIIFIFLITIVVAIVFAAAAHILPKRSKDREKTSPYECGFDPLNSARLPFSFRFFLVA ILFLLFDLEIALLFPLPAAKSSTPPSILIPISLIFMIILALGLVFEWIKGGLE--- >M musculus -MNLYTVIFINILLSLTLILVAFWLPQMNLYSEKANPYECGFDPTSSARLPFSMKFFLVA ITFLLFDLEIALLLPLPWAIQTIKTSTMMIMAFILVTILSLGLAYEWTQKGLEWTE BACE1 >M brandtii ----------MTVRRRWQG------------------RPPISEDTGDLGVGEAGKQAQRR RRSFGPVPDHKVYSEDQLCKLTYSAHISLYNYTGCILSFPEKSCLQILVDTGSSNFAVAG APHPYIDSYFDTQRSSTYRP--KGFDVTV-------KYTQGSWTGSVGEDLVTITKGFNT SFLVNIATIFESENFFLPGIQWNGILGLAYAALAKPSSSLETFFDSLVTQAGIPNVFSMQ MCGAGLPVDGSG----------TNGGSLVLGGIEPTLYKGDIWYTPIKEEWYYQIEILKL EVGGQSLNLDCREYNADKAIVDSGTTLLRLPHKVFDAVVEGVARASL--IPEFSDGFWTG SQLACWANSET---PWSYFPKISIYLREENSSRSFRITILPQLYIQPMMR-AGLNYECYR FGISPST--NALVIGATVMEGFYVIFDRARKRVGFAASTCAEIAGTP------VSEISGP FSTD-DIASNCVPTLPLNEPILWIVSYTLMSVCGIILLTLIILLL---LPVRC------- ---RHGPRDPEVVNDESSLVRHRWK >H glaber ----------MAPALPWLLLWVGSGVLPAHGTQHSI-RLPLRSG---LAGAPLGLRLPRE TD---EELGRRGSFVEMVDNLRGKSGQGYYVEM-TVGSPPQTL--NILVDTGSSNFAVGA APHPFLHRYYQRQRSSTYRDLRKGVYV---------PYTQGKWEGELGTDLVSIPHGPNV TVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQ LCGAGFPLNQSE-------AVASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASS--TEKFPDGFWLG EQLVCWQAGTT---PWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYK FAISQSS--TGTVMGAVIMEGFYVVFDRAQKRIGFAVSACHVHDEFR------TAAVEGP FVTL-DMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRC-LRCL------ ---RHQHDD---FADDISLLK---- >S franciscanus ----------VVEVYESMVVIVITIKEITVIITIVV-----------IMLLHVGL----- -----HVVVLVVIIIVIIIIITMIVIMIILIMI-IIVMIMIVIINNNYIDTGSSNFAVAA ASHNAISTYYRRNESSTYED--QGTYVKV-------PYTQGEWSGDLGQDLVQIASLGNQ SFQANIAAITESQQFFLNGSRWQGILGLGYAEIARVRTLARSWFRCLTSQTSIQDIFALQ MCGALASTNDTNLGSSADGPVEEVIGSMNIGGLDPSMYHGTMQYAPLRDEWFYEVIMTDI KVGNESLGLDCKE-----------VRNFRLYYVLLD-------------MPDVPSNFWTG MVLMCPTDSTLPNEPYHWFPTLTLDLQSTNQGQAFSLVVSPQVLLIWII--IIIIGVCSA YKILGAL--QGAVIGAVIMEGFYVVFDRENKRVGFARSTCPGYILCPSYCVAYKIPTTLH HAQISDAADCGYDRSTSYDPALTVTAYVLAGICLVCLIPVIVFALTHQINKRCKGRRGRG VVNHHRFDQEGLADNDPDTVP---- >S purpuratus MHFSLPTSRIVVVVPAAAICIVCVLIETCTAARSHVYTIPLRKGKETSFAETVGEPV--- -----RTNQVNVSVEEQKNNIRGRPGLGYYIEV-DIGTPPQKL--NVLIDTGSSNFAVAA SSHNAISTYYRRNESSTYED--QGTYVKV-------PYTQGEWSGDLGQDLVQIASLGNQ SFQANIAAITESKMFFLNDSRWQGILGLGYAEIARPDSSVEPFFDSLTSQTSIQDIFALQ MCGALASTNDTNLGSSADGPVEEVIGSMNIGGLDASLYHGTMQYAPLRDEWFYEVIMTDI RVGNDSLGLDCKEYNFDKTIVDSGTTNLRLPVRVFEAITNAIKAHTTKHMPDVPSEFWTG MNLMCPTDSTSPYEPYHWFPTLTLDLQSTNQGQAFSLVVSPQQYLRRDYD-HEDKKNCFK FAIAPSTNHAGAVIGAVIMEGFYVVFDRENKRVGFARSTCPGACEKTGTCVGNSPLITEA FNIDFDASDCGYDRSTSYDPALTITAYVLAAICLVCLIPVIVFALTHQINKRCKGRRGRG VVNHHRLDQEGLAENEPNSDP---- >L variegatus ------DNKYCISSFIFNKIQLKVIVMPSVINQSGVFFIQYNFEKTIVDSGTTNLRLPER V----FEATLNVSVDDQKNNIRGRPGLGYYIEV-DIGTPPQKV--SVLIDTGSSNFAVAA SSHDAISTYYKRNESLRIKH--YPNYIIFAPAFLYEAFLLFYFGIGPSRRLFHIAH--AL HYYYSICYV-----FFISLS-----IHLSLSLLIQPDSTVEPFFDSLTSQTSIQDIFALQ MCGALASRNDTSLESSPHQPIEEMKSSQVIGGIDSSLYNGTMQYSPLRDEWFYEVIMTDI KVGNDSLNLDCKQYNFEKTIVDSGTTNLRLPERVFEATKNAIRAHTAKDMPDVPADFWTG LVLMCPTDNTLPYEPYHWFPTLTLDLQSTNQGQAFSLVVSPQQYLRRDYD-HEDKKNCFK FSISPSSNKAGATIGAIVMEGFYVVFDREKKRVGFARSTCPGFSLFF-FLFFPKIYILLP FFLIIDASDCGFDRSNSYDPALTITAYVLAAICLVCLLPVIVFAVSHQFNKRCKGHGGRG VVNHHRLNQESLAENDISYPW---- >M musculus ----------MAPALHWLLLWVGSGMLPAQGTHLGI-RLPLRSG---LAGPPLGLRLPRE TDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEM-TVGSPPQTL--NILVDTGSSNFAVGA APHPFLHRYYQRQLSSTYRDLRKGVYV---------PYTQGKWEGELGTDLVSIPHGPNV TVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQ LCGAGFPLNQTE-------ALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRV EINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASS--TEKFPDGFWLG EQLVCWQAGTT---PWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYK FAVSQSS--TGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFR------TAAVEGP FVTA-DMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRC-LRCL------ ---RHQHDD---FADDISLLK---- CAT >H sapiens -MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTD EMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGE SGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDP DMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTD QGIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDL TKVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYP DTHRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPS-A LEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKA VKNFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL >H glaber -MADSRDPASDQMKLWKEQRAAQKPDVLTTGGGNPIGDKLNIITAGPRGPLLVQDVVFTD EMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKARVFEHIGKKTPIAVRFSTVAGE SGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAILFPSFIHSQKRNPQTHLKDP DMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNAKGEAVYCKFHYKTD QGIKNLSVEEAARLSQEDPDYGLRDLFNAIANGNFPTWTFYIQVMTFDQAETFPFNPFDL TKIWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEPSPDKMLQGRLFSYP DTHRHRLGPNYLQIPVNCPYRARVANYQRDGPMCVNHNQGGAPNYYPNSFSAPVEQRY-A LEHTSRCSAEVRRYNSADEDNVTQVRTFYTEVLNEPERRRLCENIAGHLKDAQLFIQKKA VKNFTDVHPDYGACIQALLDKYNTEKPKNTIHTFVQAGSHLAAKEKANL >M brandtii -MGDSRDPASDQMKHWKEQRNTQKPDVLTTGAGIPIGDKLNTMTTGPRGPLLVQDVVFTD EMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKRTPLAVRFSTVAGE SGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAILFPSFIHSQKRNPQTHLKDP DMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTD QGIKNLSVEEAARLSHEDPDYGLRDLFNAIATGNCPSWTFYIQVMTFSQAESCPFNPFDV TKVWPHKDYPLIPVGKMVLNRNPVNYFAEVEQLAFDPSNMPPGIEPSPDKMLQGRLFSYP DTHRHRLGPNYLQIPVNCPYRARVANYQRDGPMCVVDNQGGAPNYYPNSFSAPEHQPKLA LESSTRVSGDVRRYNTANDDNVSQVRTFYTCVLNEEERKRLCENIAGHLKDAQLFIQRKA VKNFSDVHPDYGARIQALLDKYNAEKPKNAIHTFMQHGSHLAAREKANL >S franciscanus SPNLQARPQYHPPPQ---PIPQGKTDRLTTSTGCPIDNKLATMTAGARGPVLIQDFVFTD EMSHFGRERIPERVVHAKGGGACGYFETTHDISKYCKAAPFESVGKKTPVAIRFSTVGGE AGSADTARDPRGFAVKFYSEDGNWDLVGNNTPIFFIRDPIFFPSFIHTQKRNPVTHLQDP DMFWDFITLRPEATHQVSFLFSDRGTPDGFRHMNGYGSHTFKLRNKDGGYVFCKFHFKCD QGIKNFNRHRAGELSASDPDYAIRDLYNAIATGNFPSLCLHIQVMTQEQADKHRDNPFDL TKVWSQKEFPLLPVGKMVLNLNPKNYFAEVEQIAFSPAHMIPGIEPSPDKMLQGRLFSYS DTHRHRLGTNYLQIPVNCPFAARTRSYQRDGPQCVTDNQGGAPNYFPNSFTGPVDSKN-Y EQCKFSCPGEAARYETGDDDNYTQAGIFWRDVLSEADREATVDNMASHIKDAAEYLQKRT VSDNASVF----------------------------------------L >S purpuratus --MANRDKAARQLEDHCTA-QKGKSDRLTTSTGCPIDNKLATMTAGARGPVLIQDFVFTD EMSHFGRERIPERVVHAKGAGAFGYFETTHDISKYCKAAPFESVGKKTPVAIRFSTVGGE SGSADTARDPRGFAVKFYSEDGNWDLVGNNTPIFFIRDPMFFPSFIHTQKRNPVTHLKDP DMFWDFITLRPEATHQVSFLFSDRGTPDGYRHMNGYGSHTFKLRNKDGEYVFCKFHFKCD QGIKNLNRHRAGDLSATDPDYAIRDLYNSIATGNFPSWSLHIQVMTQEQADKHRDNPFDL TKVWSQKEFPLLPVGKMVLNLNPKNYFAEVEQIAFSPAHMIPGIEPSPDKMLQGRLFSYS DTHRHRLGTNYLQIPVNCPFAARTRSYQRDGPQCVTDNQGGAPNYFPNSFTGPTDSKS-Y EQTKFTCPGEAARYETGDDDNYTQAGIFWRDVLSEADREATVDNMASHIKDAAEYLQKRT TQASATAN----------------------------------------L >L variegatus IYEIGICPLCFRLPLY----TVKEKNRLTTSTGCPIDNKLATMTAGARGPVLLQDFVFTD EMAHFGRERIPERVVHAKGAGAFGYFETTHDISKYCKAAPFESIGKKTPVAVRFSTVGGE SGSADTARDPRGFAVKFYSEDGNWDLVGNNTPIFFIRDPIFFPSFIHTQKRNPVTHLKDP DMFWDFITLRPESTHQVSFLFSDRGTPDGYRHMNGYGSHTFKLRNKQGEYVFCKFHFKCD QGIKNLNRHRAGELSAGDPDYAIRDLYNAIATNNFPSWSLHIQVMTQEQADKHRDNPFDL TKVWSQKEYPLIPVGKMVLNLNPKNYFAEVEQIAFSPAHMIPGVEPSPDKMLQGRLFSYS DTHRHRLGTNYLQIPVNCPFAARTRSYQRDGPQCVTDNQGGAPNYFPNSFSGPVDSKD-Y QQCPFEVSGVAQRYETGDDDNYSQPGIFWRDVLSEADREATVDNMASHIKDAADYLQKRA VSSLPSSE----------------------------------------- >M musculus -MSDSRDPASDQMKQWKEQRASQRPDVLTTGGGNPIGDKLNIMTAGSRGPLLVQDVVFTD EMAHFDRERIPERVVHAKGAGAFGYFEVTHDITRYSKAKVFEHIGKRTPIAVRFSTVTGE SGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDAILFPSFIHSQKRNPQTHLKDP DMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNADGEAVYCKFHYKTD QGIKNLPVGEAGRLAQEDPDYGLRDLFNAIANGNYPSWTFYIQVMTFKEAETFPFNPFDL TKVWPHKDYPLIPVGKLVLNKNPVNYFAEVEQMAFDPSNMPPGIEPSPDKMLQGRLFAYP DTHRHRLGPNYLQIPVNCPYRARVANYQRDGPMCMHDNQGGAPNYYPNSFSAPEQQRS-A LEHSVQCAVDVKRFNSANEDNVTQVRTFYTKVLNEEERKRLCENIAGHLKDAQLFIQKKA VKNFTDVHPDYGARIQALLDKYNAEKPKNAIHTYTQAGSHMAAKGKANL CETP >H sapiens -----------MLAATVLTLALLGNAHAC---------------------SKGTSHE-AG IVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIA SSQVELVEAK-SIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQL TCD-SGRVRTD--APDCYLSFHKLLLHLQGEREPGWIKQLFTNFIS-FTLKLVLKGQICK E-INV-ISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSE D--LPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGF N---TNQEIFQEVVGGFP-SQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQH SVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSES-VQSFLQSMITAV GIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS ------------------- >H glaber -----------MLAAALLSLALLSSAHPC---------------------STGPPYV-AD IVCHITKPAFLVLSQETTKVIHTAFRWASYPDIKGEKAMVLLGHVKYGLHNIQISHLSIA GSQVELAEAK-SIDISIQNVSVVFTGTLNYGYTSAWGLSIDRFVDFEIDSAIDLXINTQL ICD-SGRVRTD--APDCHLSFHKLLLYLHGEHEPRWIKRLFTNFIS-FTLKLALKGQICK E-INV-ISNIMADFVQSRATNILSDGDXGVDISLTGLSVITATYLESHRKGHFIYKSISE D--LVLPTFSPSLLGDSRMLYFWFSEQVLDSFAKATFQDGHLMLSLMGEKFKAALETQAL N---INQETFAELFSSFPPSQTQVTVHCLTRPRISCQNKGI-IVSSVMVKFLFPHPDGQH SVAHTFEEDIITTIQASYSRKKLFLSLLDFQITPKTASNEAESCSEA-VRSFLQSLITTV GIPEVMSRLQVALTALMNSKGLHFFDLINPEIITQDGSLLLQMDFGFPEHLLVDFLQSLS ------------------- >M brandtii -----------MARFAALFLALLAGAHAA-------------------------AEI-PG CKIRITSKALELLKQEGLRFLEQELETVTIPDLGGHE-----GHFYYNISEVTVTEMQLT SSELHFQPEQ-ELVLQTSNSSLGLRFRRQLRY---WIFYDGGYINAS-AQGISIHTALQL SRDPTGRIKVA--NVSCQASVSKLYAAFEG--TFKIVYQFLSTFVT-SGMHFLLNQQICP V-IHHAGMVLLNSLLDTVPVRSSVDNLVGIDYSLVKDPVVSTSYMDMEFRGAFFPLG-QG NWSLPNRAVEPQLQEEERMVYVAFSEFFFDSALESYFQAGALQLSLVGDKVPKDLDMLLR AS--YFGSIVLLQSPAVIDSPLKLELRVVAPPYCTIKPSGTTVSVTASVTVALVPPNQPE VQLSSMIMDARLSAKMALQGKALRIHLDLRKFRIYSNQSALESLALIPLQAPLKTMLQFG VMPLLNERTRRGVQIPL----PEGMDFVREVVTNHAGFLTIAADLHFAKGLREVIEKNRP ANTMDSGVPSAPPPSTAAV >M musculus ----------MKAGTGPLLSTLLGLLFLS---------------------IQGTGGVNPG VVARITDKGLAYAAKEGLVALQRELYKITLPDFSGDFKIKAVGRGQYEFHSLEIQNCELR GSSLKLLPGQ-GLSLAISDSSIGVRGKWKVRK---SFLKLHGSFDLD-VKGVTISVDLLL GMDPSGRPTVS--ASGCSSRICDLDVHISG--NVGWLLNLFHNQIE-SKLQKVLENKVCE M-IQKSVTSDLQPYLQTLPVTAEIDNVLGIDYSLVAAPQAKAQVLDVMFKGEIFNRNHRS PVATPTPTMSLP-EDSKQMVYFAISDYAFNIASRVYHQAGYLNFSITDDMLPHDSGIRLN TK--AFRPFTPQIYKKYPDMKLELLGTVVSAPILNVSPGNLSLAPQMEIEGFVILPTSAR EPVFRLGVVTNVFASLTFNNSKVTGMLHPDKAQVRLIESKVGMFNVNLFQAFLNYYLLNS LYPDVNAELAQGFPLPL----PRHIQLHDLDFQIRKDFLYLGANVQYMRV---------- ------------------- >L variegatus RRSISIPPKTVMARLKKISPIIIMSIQSKYCAYCYISPYSYY----IKWKLAGWNKL-PG FKARITQKGLDFVRDVGIHMLQTKIQQLTIPDIHGKADVK-VGHIYYDVTKMHITTFSIP SATLTTNPTAGGLTLKTSGVSIKVHGDWHYSTHGLAIATIQFIVCHYVSDAEAL---TGC GVDATGRPSISSQASDCSFSVGGLDIKLHG--GARFVCKLLDLFLSAFGFALCLNFSLFV Y-VSL-YFYLLLLYSICAIVIAPVEDIIEIDYSLVESPSFNGS-INTAHQGEVYPLGNKT ECPLPVPQIPPD-SDVSRMVSIWITEYLPNSAGYVLQNIGFLQYNVTPDNVSSHKSKIIY AKS-SLSLIISQISKMYPNMAMQINVNSTKAPVVKVASTGVQAVLVAYCSPYAILPNKTK AYLFTLSVVILPDLPYYLAPHPLSHQAMHCSIHQLTRYKA---HSYLLIDYFLTPLVRIY GRTRVIKNAK------------KFVQYNNRIAGERKIYLFVTGHCGSPFKPISE------ ------------------- >S franciscanus --MVWSGVGSNMFRGSLMSPILAGFLVVCCILGSSANRNVYRKVGPYKWKLNGWNKE-PG FKARISNIAFISVRDVGIQMLQKQIQQLTIPDIHGSADIG-IGKVKYDVTSIHITAFSIP IASLTTNPAAGGLTLKTSGIYLKVHGDWHYKIGGLSVSIILMHLLLN-DTLSPIFTSLNA GVDTTGRPNISSKASDCSFNIGSLDVDLHG--GARYCT--YIRRSC-GRRHGCGGGPYCA IPIAQPCIRSSQYYIFQIAVIAPVGDVIEIDYSLVESPSFNGS-ISTCFQGEVYPIGNQT ECPLPVSQIPPD-SDTSRMVFIWITEYLPNSAGYVLQNIGFLQYNVTPENVSRRHTRLIM TCLSVVKHNF-QISKMYPNMAMQINVNSTKAPAVKIAPTGIEAVLVADCSPYAVQPNKTL AYLFTLSMVI------SFSHNFFLLKII---VALSLRCKALEVHPQKGIQSLLFGMEPTI IYSGVN------------------------------------------------------ ------------------- >S purpuratus --MVRSGVGSDMFSGSSMSPILAGFLVVCCVLGSSANRNVYRKVGPYKWKLNGWNKE-PG FKARISQKGLDFLRDVGIQMLQKQIQQLTIPDIHGSADIG-IGDVKYDVTNIRITTFSIP TASLTPDPAAGGLTLKTSGINLKVHGDWHYKIGGFIPVSDSGDFDAS-ASSISLAVTLRI GVDATGRPNISSKASDCSFNIGGLDVDLHG--GASWLYNLFDDKIG-DAIKDSLNGQICD TVIDE-VNGSLEDELKDLQVIAPVGDVVEIDYSLVESPSFNGS-ISTAHKGEVYPIGNTT ECPLPVPQIPPD-SDISRMVFIWITEYLPNSAGYALQNVGFLQYNVTPENVPAEEKNYLN TSNFALDLLIPQINKMYPNMAMQINVNSTKAPVVKVASTGVQAVLVGDFIPYAILPNKTL AYLFTLSVTISAKVSVNFTGNNITWNISSFSTTMKAVRSAVGPFFTSALQLAVNTAIKVD LIPDLNKLGAVGAPLPQ----LDGFNFTKPVVSLGEGFLKIGTDLTYTP----------- CLK1 >H sapiens MSCAGAAAAPRLWRLRPGARRSLSAYGRRTSVRFRSSGMTLDN-----ISRAAVDRIIRV DHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKDHLKKFNELMVTFRVRPTVLMPLW NVLGFALGAGTALLGKEGAMACTVAVEESIAHHYNNQIRTLMEEDPEKYEELLQLIKKFR DEELEHHDIGLDHDAELAPAYAV----LKSIIQAGCRVAIYLSERL >H glaber ----------------------IAAYGKKIGLRFCSSGMTLDN-----INWAAMDRIIRV DHAGEYGANRILAGQMAVLGRTSVGPVIQKMWDQEKAHLKKFSELMVAFRVRPTVLMPLW NVTGFALGAGTALLGKEGAMACTVAVEETIAHHYNNQIRTLMEEDPEKYEELLQLIKKFR DEELEHHDTGLSHDAELAPAYAI----LKSVIQAGCRAAIYLSERL >M brandtii ------------------------------------------------------------ ------------------------------------------------------------ -------------------MACTVAVEESIAHHYNNQIRTLMEEDPEKYEELLQVIKKFR DEELEHHDIGLEHDAELAPAYAI----LKKVIQAGCSAAIYLSERF >S franciscanus MQNLTSIRYCVLRQYKLRMSRAIVEV-KGQRSASSLSGLT---------RREMIDRIIRV DHAGEVGADRIYAGQLAVLKNTSVGPLIQEMWDQEKHHMETFERLIPERRVRPTALLPIW NVAGFVLGHQSL----------------AICKYFSNITCKLL------------------ ---------------------------LPFQIP------------- >S_purpuratus MQNLTSIRYCVLRQYKLRMSRAIVEV-KGQRSASSLSGLT---------RREMIDRFIRV DHAGEVGADRIYAGQLAVLKNTSVGPLIQEMWDQEKHHKETFERLIPERRVRPTVLLPIW NVAGYVLGAGTALMGKEAAMACTVAVEESIGQHYNDQIRALIEDDPEVHKELLEIIKQFR DEELEHLNTGLENDAKKVLVRLSWVRKLQWLAQ------------- >L variegatus MQNLGSMRYCVLRQYKLRAMRAVTEV-KGQRSASSMSGLT---------RKEMIDRIIRV DHAGEVGADRIYAGQLAVLKNSSVGPLIQEMWDQEKHHKETFERLIPEHRVRPTALLPIW NVAGFVLGAGHALIGKEAAMACTVAVEESIGEHYNEQIRALIEDDPEVHKELLEIIKEFR DDELEHLNTGLENDAKKV---------IRIYAPAVFRSAIS----- >C elegans --------------------------MFRVITRGAHTAAS---------RQALIEKIIRV DHAGELGADRIYAGQLAVLQGSSVGSVIKKMWDEEKEHLDTMERLAAKHNVPHTVFSPVF SVAAYALGVGSALLGKEGAMACTIAVEELIGQHYNDQLKELLADDPETHKELLKILTRLR DEELHHHDTGVEHDGMKAPAYSA----LKWIIQTGCKGAIAIAEKI >M musculus MSAAGAIAAASVGRLRTGVRRPFSEYGRGLIIRCHSSGMTLDN-----INRAAVDRIIRV DHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKNHLKKFNELMIAFRVRPTVLMPLW NVAGFALGAGTALLGKEGAMACTVAVEESIANHYNNQIRMLMEEDPEKYEELLQVIKQFR DEELEHHDTGLDHDAELAPAYAL----LKRIIQAGCSAAIYLSERF >SIG ~~~~~------------------------------------------------------- ------------------------------------------------------------ -------------------------------+---------------------------- COX1 >H sapiens MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTA HAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEA GAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQ TPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH PEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD TRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLAN SSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLNQTYAKIHFAIMFIG VNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNVLSSVGSFISLTAVMLMIFMIWEAFASKR KVLMVEEPSMNLEWLYGC-PPPYHTFEE--PVYMKS- >M brandtii ----------------TLYLMFGAWAGMVGTALSLLIRAELGQPGALLGDDQIYNVIVTA HAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEA GAGTGWTVYPPLAGNLAHAGASVDLAIFSLHLAGVSSILGAINFITTIINMKPPALSQYQ TPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLF----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >H glaber MFINRWLFSTNHKDIGTLYLLFGAWAGMTGTALSILIRTELGQPGTLLGDDQIYNVIVTA HAFIMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEA GAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQ TPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH PEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD TRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLAN SSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFSGYTLDPTWAKIQFSVMFIG VNMTFFPQHFLGLSGMPRRYSDYPDAYTMWNTLSSMGSLISLTAVMMMVFMIWEAFASKR EVLMTEMTSTNLEWIHGC-PPPFHTFEE--PTYIKM- >S franciscanus MQLRR-LFSTNHKDIGTLYLIFGA-AGMVGTAMSVIIRAELAQPGSLLKDDQIYKVVVTA HALVMLFFMVMPIMIGGFGN-LIPLMIGAPDMAFPRMKNMRF-LIPPSFIL--------- ------------------------------------------------------------ ------------------LPVLAGAITMLLTDRNINTTFFDPAGGGDPILFQHLF-FFGH PEVYILILPGFGMISHVIAHYSGKREPFGYLGMVYAMIAIGVLGFLVWAHHMFTVGMDVD TRAYFTAATMIIAVPTGIKVFR-MATLQGSNLQCETPLLWALGFVFLFTLGGLTGIVLAN SSIDVVLHDTYYVVAHFHYVLSMGAVFAIFAGFTH-FPLFSGYSLHPL-GKVHFFIMFVG VNLTFFPQHFLGLAGMPRRYSDYPDAYTL-NTISSIG---SVVAMLFFLFLI-EAFASQR EGITPEFSHASLE-QYTSFPPSHHTFDETPSTIIIVK >S purpuratus MQLSRWLFSTNHKDIGTLYLIFGAWAGMVGTAMSVIIRAELAQPGSLLNDDQIYNVVVTA HALVMIFFMVMPIMIGGFGNWLIPLMIGAPDMAFPRMNNMSFWLIPPSFILLLASAGVEN GAGTGWTIYPPLSSNITHAGSSVDLAIFSLHLAGASSILGLINFITTIINMRTPGMSLDR LPLFVWSVFVTAFLLLLSLPVLAGAITMLLTDRNINTTFFDPAGGGDPILFQHLFWLFGH PEVYILILPGFGMISHVIAHYSGKREPFGYLGLVYAMIAIGVLGFLVWAHHMFTVGMDVD TRAYFTAATMIIAVPTGLKVFSWMAKLQGSNLQWSLPLLWTLGIVFLFTLGGLTGIVLAN SSIDFVLHDTYYVVAHFHYVLSMGAVFAIFAGFTHWFPLFSGYSLHPLWGKVHFFIMFVG VNLTFFPQHFLGLAGMPRRYSDYPDAYTLWNTISSIGSTISVVAMLFFLFLIWEAFASQR EGITPEFSHASLEWQYTSFPPSHHTFDETPSTIIIVK >L variegatus MQLRR-LFSTNHKDIGTLYLIFGA-AGMVGTAMRVIIRAELAQPGSLLKDDQIYNVVVTA HALVMIFFMAMPIMIGGLGN-LIPLMIGAPDMAFPRMKKMRF-LVPPSFILLLASAGVER GAGTG-TIYPPLSSKIAHAGGSVDLAIFSLHLAGASSILASINFITTIINMRTPGMSFDR LPLFV-SVFVTAFLLLLSLPVLAGAITMLLTDRNINTTFFDPAGGGDPILFQHLF-FFGH PEVYILILPGFGMISHVIAHYSGKREPFGYLGMVYAMIAIGILGFLV-AHHMFTVGMDVD TRAYFTAATMIIAVPTGIKVFR-MATLQGSNLQ-ETPLLWALGFVFLFTLGGLTGIVLAN SSIDVVLHDTYYVVAHFHYVLSMGAVFAIFAGFTH-FPLFSGYSLHPL-GKVHFFIMFVG VNLTFFPQHFLGLAGMPRRYSDYPDAYTL-NTVSSIGSTISVVAMLFFLFLI-EAFASQR EGITPEFSHASLEWQYTSFPPSHHTFDETPSTIIIVK >M musculus MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQPGTLLGDDQIYNVIVTA HAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEA GAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQ TPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH PEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGLDVD TRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLSN SSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFSGFTLDDTWAKAHFAIMFVG VNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVLIMIFMIWEAFASKR EVMSVSYASTNLEWLHGC-PPPYHTFEEPTYVKVK COX2 >S purpuratus MGTWAQFGLQDASSPLMEELTYFHDYALIVLTLITILVFYGLVSLLVSSNTNRFFFEGQE LETIWTVIPALILILIALPSLQLLYLMDEVNDPFLTIKAFGHQWYWSYEYTDFNDLEFDS YMVPTSDVSFGNPRLLEVDNRLVLPMQNPIRVLVSSADVLHSWAVPSLGTKMDAVPGRLN QTTFFAARTGVFYGQCSEICGANHSFMPIVIESVPFNTFENWVTQYLEE >L variegatus -MATAQFGLQDASSPLMEELTYFHDYALIVLTLITILVFYGLASLLVSSSTNRFFLEGQE LETI-TVIPALILIFIALPSLQLLYLMDEVKDPFLTIKAIGHQ--YSYEYTDYKDLEFDS YMVPTSDISLRDARLLEVDNRLILPMQNPIRVLVSSADVLHS-AVPSLGVKMDAVPGRLN QTTFFAARTGLFYGQCSEICGANHRFMPIVIESVPFNTFEN-VAQYLEE >S franciscanus -MATAQFGLQDASSPLMEELTYFHDYALIVLTLITILVFYGLVSLLVSSNTNRFFLEGQE LETI-TVIPALILILIALPSLQLLYLMDEVKDPFLTIKAIGHQ--YRYEYTDYKDLEFDS YMVPTSDVSLGNPRLLEVDNRLILPMQNPIRVLVSSADVLHS-AVPSLGVKMDAVPGRLN QTTFFAARTGLFYGQCSEICGANHSFMPIVIESVPFNTFEN-VAQYLEE >H sapiens MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQE METVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNS YMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLN QTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL-- >H glaber MPYPHQLGFQDATSPIMEELLYFHDHTLMIVFLISSLVLYTISTMLSTKLTHTNTMNAQE IEMVWTILPAMILILIALPSLRILYMIDEINDPSLTVKTLGHQWYWSYEYTDYEELCFDS YMVPSTDLKPGELRLLEVDNRVVLPMKTPVRMLISSEDVLHSWAVPSLGLKTDAVPGRLN QTTLMSSRPGLFYGQCSEICGSNHSFMPIVIEMVPLKTFESWSSLMT-- >233142508__M_musculus 121 origGI 422034515 MAYPFQLGLQDATSPIMEELMNFHDHTLMIVFLISSLVLYIISLMLTTKLTHTSTMDAQE IETIWTILPAVILIMIALPSLRILYMMDEINNPVLTVKTMGHQWYWSYEYTDYEDLCFDS YMIPTNDLKPGELRLLEVDNRVVLPMELPIRMLISSEDVLHSWAVPSLGLKTDAIPGRLN QATVTSNRPGLFYGQCSEICGSNHSFMPIVLEMVPLKYFENWSASMI COX3 >H sapiens MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRD VTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTG ITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASE YFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAW YWHFVDVVWLFLYVSIXWWGS >H glaber MNHQTHAFHMVNPSPWPLTGALSALLITSGLTMWFHFNSMTLMLLGLLACIMTMYQWWRD IVREGTYQGHHTPTVQKGLRYGMVLFIISEVFFFAGFFWAFYHSSLAPTPELGGHWPPAG INPLNPTEVPLLNTAILLASGVSITWAHHSLMEGHRKHVIQSLLTTIILGIYFTLLQASE YFEAPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICLIRQLLFHFTSKHHFGFEAAAW YWHFVDVVWLFLYVSIYWWGS >S franciscanus MAHQ-HPYHLVDQSPCPLTGAISGLMMTSGLVL-FHTQRLILLSVGLLLLITTMINWWRD IIREATFQGRHTAIVEKGLRYGMILFITSEVCFFFA---AFFHRRLAPSVEIGVA-PPTG ITPLNPFLVPLLKTAVLLSSGVTIT-SHHRILAGNRTESIQALFLTVALGMYFTILQA-E YIDAPFTIADSVYGSTFFVATGFHGLHVIIGTTFLMVCLFRLAGHHFSTHHHFGFEAAA- YWHFVDVV-LFLYVCI-YWGS >S purpuratus MAHQ-HPYHLVDQSPWPLTGAFSGLMMTSGNVLWFHTQKTNLTLVGFLLLITNMVNWWRD IIRKANFQGSHTAIVNKGMRYGMILFITSEVCFFFAFFWAFFHSSLAPSVEIGVAWPPSG ITPLNPFLVPLLNTGVLLSSGVTLSWSHHSILAGNRTESIQALFLTVALGSYFTALQAWE YIDAPFTIADSVYGSTFFVATGFHGLQVIIGTTFLMVCLFRTAGRHFSTHHHFGFEAAAW YWHFVDVVWFVLYWLIYWWGA >M musculus MTHQTHAYHMVNPSPWPLTGAFSALLLTSGLVMWFHYNSITLLTLGLLTNILTMYQWWRD VIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTG ISPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGKRNHMNQALLITIMLGLYFTILQASE YFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVCLLRQLKFHFTSKHHFGFEAAAW YWHFVDVVWLFLYVSIYWWGS >L variegatus MAHQ-HPYHLVDQSP-PLTGAIRGLMMTSGLVL-FHTQRIVLLTVGFLLLVTTMIN--RD IVREATFQGRHTAIVEKGLRYGMILFITSEVCFFFAFF-AFFHRRLAPSTEIGLT-PPTG ITPLNPFLVPLLKTAVLLSSGVTIT-SHHRILAGNRTEAIQALFLTVTLGIYFTVLQA-E YIDSPFTIADRVYGSTFFVATGFHGLHVIIGTTFLIVCLFRLAGHHFSTHHHFGFEAAA- YWHFVDVV-LFLYVCI-YWGS COX4 >H sapiens MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKH--LSAS QKALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVI MWQKHYVYGPLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK >H_glaber MLATRVFSLISKRAISTSVCARAHGSVVKSEDYALPSYVDRRDYPLPDVAHVQQ--LSAS QKALKEKEKASWSSLTRDEKVELYRIRFNESFAEMNRSTNEWKTVVGAAMFFIGFTGLIL IWEKRHVYGPIPHTFDEEWVAMQTKRMLDMKASPIQGFSAKWDYDKNEWKK >M brandtii MLTTRVFSLIGKRAISTSVCARAHGSVVKSEDFSLPAYVDRRDYPLPDVAHVKS--LSAS QKALKEKEKNPWNSLSIDEKVELYRIKFNESFAEMNRSTNEWKTVVGAAMFFIGFTALVL IWEKRFVYGPIPHTFEEEWVAKQTKRMLDMKVSPIQGFSAKWDYDKNEWKK >S francifcanus --MASLMRLSLRRVASNV-------SRTPKRNFHDKLYADRLDYPAPNCRFLQETELSAE MQALKVKERGDWKALTQADKKEVYRMSFNKTYSEMRAPTGEWKYVVGGVCIAIAISGVIY LFQPAYSSPPSPHHMSDEWQEAQLRYQIAIRNGPVTGISSQWDYEKNEWKK >S purpuratus --MASLMRLSVRRVASSV-------SRTPKRNFHDKLYADRLDYPAPNCRFVQEAELSAE MQALKVKERGDWKALTQADKKELYRMSFNKTYSEMRAPTGEWKYVIGGVCIAIAVSGVIY GFQKAYISPPLPHTMSDEWQEAQLRYQIAIRNGPVTGIASQWDYEKNEWKK >L variegatus --MASLMRLSVRRAASNV-------SKTPKRNFHDKLYADRLDYPAPNCRFMKEADLSSD MQALKVKERGDWKALSQAEKKEVYRMSFNKTYSEMRAPTGEWKYIIGGVSIALAFSAVIY GFQKAYVSPPLPHTMSPEWQEAQLRREIAIRNGPVTGTASKWDYEKNEWKK >M musculus MLASRALSLIGKRAISTSVCLRAHGSVVKSEDYAFPTYADRRDYPLPDVAHVTM--LSAS QKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNRGTNEWKTVVGMAMFFIGFTALVL IWEKSYVYGPIPHTFDRDWVAMQTKRMLDMKANPIQGFSAKWDYDKNEWKK COX5b >H sapiens MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKG-- LDPYNVLAPKGASGTREDPNLVPSISNKRIVGCI---CEEDNTSVVWFWLHKGEAQRCPR CGAHYKLVPQQ----LAH >M brandtii MASRLLRGTGALVAQALRARGPNAAAAVRSMASAGGVPTDDEQATGLEREVMLAARKG-- LDPYNMLAPKPASGTKEDPNLVPSITNKRIVGCI---CEEDNSAVIWFWVHKGETQRCPS CGTHYKLVPHQ----LSH >S franciscanus MATITLRKCALTAARRCLFRQSS-----RAMAAGGGNFLIFTVIGKMCTSMLVL------ YCSLGLETPVRTRVIAPIPLFISSLS--LFVSHV---GEEEQTHINWMWLYTGEPQRC-E CGHWFKLSEVEGIAAAAH >S purpuratus MATITLRKCALTAARRCLYSQSS-----RAMAAGGGIPDNFEHATGLEKKELDRIKAGD- SDPFQLNVRRVAAGTKTKPVEVTSAFQKRIVGCI---CEEEQTHINWMWLYTGEPQRC-E CGHWFKLQEVEGIAAAAH >L variegatus MATITLRKCALTAARRCLFSQSS-----RAMAAGGGIPDNFEHATGLEKKELERIKAGDA AAPLSF-----SASISIAPIPFIYIHEPCRPSCIPYALEEEQTHINWMWLYTGEPQRC-E CGHWFKLTEVEGIAAAAA >M musculus MASRLLRGVGALAAQALRAHGPRGAAVTRSMASGGGVPTDEEQATGLEREIMIAAQKG-- LDPYNMLPPKAASGTKEDPNLVPSISNKRIVGCI---CEEDNCTVIWFWLHKGESQRCPN CGTHYKLVPHQ----MAH COX6a >H sapiens ---MAVVGVSSVSRLLGRSRPQLGRPMSSGAHGEEGSARMWKTLTFFVALPGVAVSMLNV YL----KSHHGEHERPEFIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE >H glaber ----AAIAASRVSRLLGRSRPQVGRIMSSGAHGEQGSARMWKALTYFVALPGVGVSMLNV FL----KSRHGKEERPEFIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE >M brandtii ---MATAAASRVAGLLDRLRPQLARPMSSGAHSQEGSARLWKSLTYFVALPGVAVSMLNV FL----KSRHGEHERPEFVAYPHLRIRTKPFPWGDGNHTLFHNPHLNPLPTGYEDE >S franciscanus ------------------------------------------------------SSLTSI FI---------------FFFFFHL-----SFPWGDGNHSLFHNAEANALPEGYEEE >S purpuratus ----------MLELWLWSDHEMVIVFL---DFLFLGSAKTWKYMSFLVAIPGVIFCMVNA YKGEMEHKAHFAAHKPEFHAYTHLRIRTKSFPWGDGNHSLFHNVESNALPEGYEEE >L variegatus -----------LGEYSGLSKRDSGIFF---CFVLSGTAKTWKYMSFLVALPGVMFCMVNA YKGEMEHKAHLAHHKPEFVAYSHISIRTQAFPWGDGNHSLFHNAESNALPEGYEE- >M musculus MMASAVLSASRVSRPLGRALPGLRRPMSSGAHGEEGSARMWKALTYFVALPGVGVSMLNV FL----KSRHEEHERPPFVAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE COX6b >H sapiens MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRV YQSLCPTSWVTDWDEQRAEGTFPGKI >H glaber MAEDIKTKIKNYKTAPFDSRFPNQNQTRNCWQNYLDYHRCQKAMNAKGGDVSVCEWYHRV YKSLCPISWVSTWDERRVEGTFPGKI >M brandtii MAEDIKTKIKNYRTAPFDSHFPNQNQTRNCWQNYLDFHRCEKAMTAKGGDVSVCEWYRRV YKSLCPISWVSAWDDRRAEGTFPGKI >S franciscanus -MADIKEVLSNYKTAPFDARFPNTNQTKNCWQNYVDFHRCQK---MKGEDFEPCEYFRRV YKSLCPIAWVS------MTHTY---- >S purpuratus -MADIKEVLENYKTAPFDARFPNTNQTKNCWQNYVDFHRCQK---MKGEDYEPCEYFKRV YKSLCPIAWAENWDSQREEGTFASKI >L variegatus -MSEFKEILENYRTAPFDARFPNTNQTKNCWQNYVDFHRCQK---KKGEDYEPCEYFRRV YKSLCPLAWVSINYLNDIYYQYCAYD >M musculus MAEDIKTKIKNYKTAPFDSRFPNQNQTKNCWQNYLDFHRCEKAMTAKGGDVSVCEWYRRV YKSLCPVSWVSAWDDRIAEGTFPGKI COX6c >H sapiens ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MAPEV-LPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKK AYADFYRNYDVMKDFEEMRKAGIFQSVK------- >H glaber ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MSSSA-LTKPQMRGLLARRLRIHMVGAFIVSLGVATLYKFGVAEPRKK AYADFYRNYDSMKDFEEMRKAGIFQSAK------- >M brandtii MSERHSGQVGTGVGNEMDSPTVTIKYTGFKDFSSTSSFQDSGYSELLKSYSVDNTLFLVK QEDDPTINYEFFEPVSPGLTDPLETPTKRKRFIIFRKKSAIPPDFCETPKLGGKRYLRRR RRLDVSFSPLKRNYESENSSIESSISEVLNFEEDIPSSASGSPRQNNFSALVTSTLKTEE ATLSPQKLRLNFSQQKTSTVDDSKDDCSLFEDECISPIQGNNFKDSITHDFSDSSPCVND ENTFPKLLGSSSSGTTCETDEDIFVTPISNLVANIKFKAGQRFFPQVRGNISTPEDSGFN SLCLDKSEDSLSDQESSFQELLQKHKGTLKVEDTIRRSRRLGRLRRLSTLREQGSQSETE EESQIIHSESEITPAASSDILESQPSSDSQSEELILGFNNLSNTPALQLVHELFMKNKKR RFQQSGTREFLEDRDEAKIAVLQCVLAGLIGKKMGIEKLDILTELKYRNLKHILAVVLDS LSAESLCSVWSVSRNWREIIVQNKKANQRRRFYLTQLKTDAKQAVLNVQDAATRFQLSNR SALRSVQAQARTPSSQKEQVSTFSPWGEVLTPIASSSIIDSHSKQEEYVREDSLATDNFL VDYFNEFLSLPTFSEAIRFNVNYGVFEVVNNAPQLLEKQLKKILQSQQPRNPIYDVVRKA KNDIKPAQMSDPYKAETININYSVMCLNREQGIQWIKKERLPAFLESDCYFEYRHLEKMK KNYLVSSGDRHLSTEILTKLKLLDGSQWNKEHLINIQTEVVKPLLLYWAPRFCVTHSSAI RKASAELKLWHRRQEKPREDIDPFPQIATLLPLRPKSCIPQISDTEKEESSLVPPPTSPK KPSTASQKPRKGETQRSISPKDSVTEKGSKQMSERYNVIHLTSYTDISECLKPELERRFT YSEEPLVKTMADGALGGSDMENLLQSLYVENRAGFFFTKFCEHSGNELWKNSVYFWFDLQ AYHQLFYQETLHPFKVCKQAQLLFATYVAPSATLDIGLQQQKKKEIYMKIQPPFEDLFDT AEEYILLLLLEPWTRMVQLDQLAYKQVKLVEETRQLDSVNFRKLQALYKETVFKKAEVKL VEETRQLDSVNFRKLQALYKETVFKKAEDATSEIGTGIPPHPAATKSTEYWNIVPAEYKN FNFNNLLNNKLEFEHFRQFLEAYSASIDLMCWADIEQFRSIPYKDRKLREAKSIYIKNKY LNKTYFLGPTSPASPYQQDQIMSLCGGWGKTLHEQLDPPVFVEVQKHVLKRIENVWLPLF LASEQFAARQKIKLQLKEATDELLLQKHEEKIGIWKPVESKWISSSSEIIAFRKALLNPV TANQFQRFVALKGDLLENGVLFWQEVQKYKDLCHSHCDESIIHRKVMTIINCFINSSIPP ALQIDIPVEQAQKIIEHRKELGPYVFREAQMTIFGVLFKFWPQFCEFRKNLTDEKIMSAL ERRKEYHRQKKRSTVVEEERFQKTPYPDIENIKLAVPSELSPASTVFGWNRPRNAPSSNL RPPSNLSLGFYFDCGDVALEGSGFFFCDLAEKRCQGAEHLKEAKPCSLKRCQGAEHLKDA KLCSLPGRAEASQGRWAKLRAVEAALALERSLTQALWELQAQVLPKQTLSSLASWRTIFW NVLRPPKETITAMSAGT-LPKPQMRGLLAKRLRVHIVGAIIVSLGVAASYKFGVAEPRKK AYADFYRNYDSMKDFEEMRKAGIFQSTK------- >S franciscanus ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MAA---LPRPQMRGLLSSFLTRHFIIGSVLSLAGAGLVKVFVYDARKK LYTEFYKTYDAQADFERMRELGVFQSARPLSEER- >S purpuratus ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MAA---LPRPKMRGLLSSFLTRHFIIGSVLSLAGAGLVKVFLYDARKK LYTEFYKTYDAQADFERMRELGVFQSARPLSEEAE >M musculus ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MSSGALLPKPQMRGLLAKRLRVHIAGAFIVALGVAAAYKFGVAEPRKK AYAEFYRNYDSMKDFEEMRKAGIFQSAK------- >L variegatus ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ 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------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------MSA---LPRPQMRGLLKSFLTRHFIIGATLSVTGAALVKVFCKLHFSP YWVQSYKTYDAQADFERMRELGVFQSARPLSEQE- COX7c >H sapiens MLGQSI-----RRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLV VRHQLLKT >H glaber MLGQSI-----RRFTASAVRRSHYEEGPGKNLPFSVENKWRLLVMMTLYFGSGFAAPFFI VRHQLLKK >S franciscanus MLLSRLAVVSRRSFGTSVIRQAGYGEGPGTNMPFPTRNKWLLLGIMAAFFGSGFAAPFIL VRHQLLKK >S purpuratus MVFSRLAVISRRSFGTSVIRQAGYGEGPGTNMPFPTRNKWLLLGIMAAFFGSGFAAPFVL VRHQLLKK >L variegatus MVFSRLAVVSRRSFGTSVIRQGGYGEGPGTNMPFPTKNKWALLGIMAAFFGSGFAAPFIL VRHQLLKK >M musculus MLGQSI-----RRFTTSVVRRSHYEEGPGKNLPFSVENKWQLLAMMTVYFGSGFAAPFFI VRHQLLKK CuZnSOD >H sapiens MATKAVCVLKGDGPVQGIINFEQK---ESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAG CTSAGPHFNPLSRKHGG--PKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIG RTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ >H glaber MATKAVCVLKGDGPVHGTIHFEQQ---EGNGPVVVKGRIAGLNEGQHGFHVHEFGDNTKG CTSAGPHFNPLSKKHGG--PKDEERHVGDLGNVTAGTDGVAEVSIEDSLISLFGPNSIIG RTMVVHEKEDDLGKGGNEESTKTGNAGSRLACGVIGIAQ >M brandtii -LLWGRADSMSP-TWSQTCASLWI---QGNGKVKVSGSIRELTEGEHGFHVHQFGDNTQG CTSAGPHFNPLSKTHGG--PQDEERHVGDLGNVTAGPDGVANVLIEDSVIALSGDHSIIG RTLVVHEKRDDLGKGGNDESKKTGNAGSRLACGVIGITQ >S franciscanus KKQYSISHSISS-P---SCLFQFVINSHQSNSVSVKGKLTLAAPSQHGFHVHQYGDYSGS CSTTGGHYNPDGVDHAS--PTSAYRHVGDLGNVQADASGRIEVSLSDKYASLSGAQAIIG RAFVVRCYVLSIIR--QSEKLKYCKKYHSECCRILERLS >S purpuratus MSVKAVCMLVGE-AVKGRIEFEQG---EGSNSVSVKGEVTGLAPGQHGFHIHQFGDYTNG CVSAGGHFNPFGKEHGA--PEDEMRHVGDLGNIIADASGKVDVNLSDKLLSLSGPQSIIG RAVVVHADVDDLGKGGHATSKTTGNAGGRLACGVIGIQA >L variegatus PKQFYFCEKLYE-VFSVICSYYL-----AVGSVNVSGTVTGLAPGQHGFHIHQFGDNTNG IVKSPLNILSCGMYYSIIFP---YRHVGDLGNIVADDSGTANVNITDRQLSLSGPQSIIG RSVVVHADIDDLGKGGHELSKTTGNAGGRLACGVIGIRK >M musculus -AMKAVCVLKGDGPVQGTIHFEQK---ASGEPVVLSGQITGLTEGQHGFHVHQYGDNTQG CTSAGPHFNPHSKKHGG--PADEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIG RTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ CYTB >H sapiens -MTPMRKTNPLMKLINHSFIDLPTPFNISAWWNFGSLLGACLILQITTGLFLAMHYSPDA STAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIIL LLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFF TFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSL MTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSIL ILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYF TTILILMPTISLIENKMLKWA >H glaber -MTNIRKSHPLIKIINHSFIDLPTPSSISYWWNFGSLLGACLILQIITGLFLSMHYTADT ATAFSSVAHICRDVNYGWLIRYLHANGASMFFICLYLHVGRGMYYGSYMFMETWNIGIIL LLSVMATAFMGYVLPWGQMSFWGATVITNLFSAIPYIGPTLVEWIWGGFAVDKATLTRFF AFHFILPFIITALTMVHLLFLHETGSNNPSGINSDSDKIPFHPYYSFKDFMGLQIMLLIL LTLTLFHPDLLGDPDNYTPANPMSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSIL ILVALPLLHTSKQRSMMFRPISQCLFWTFISTLLTLTWIGSQPVEYPYIIIGQLASILYF LIILVLMPLAGLVENKMMK-- >M brandtii -MTNIRKSHPLMKIINSSFIDLPAPSNISSWWNFGSLLGICLALQILTGLFLAMHYTSDT TTAFNSVTHICRDVNYGWVLRYLHANGASMFFICLYLHVGRGLYYGSYMYTETWNIGVIL LFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFF AFHFLLPFIIAAMVMVHLLFLHETGSNNPTGIPSNADMIPFHPYYTIKDILGLLLMITVL LMLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSIL ILIIIPLLHTSKQRSMTFRPLSQCLFWLLTADLFTLTWIGGQPVEHPYVIIGQLASILYF SIIIILMPLISLMENHLLKW- >S franciscanus MAAPLRKEHPIFRILKSTFVDLPLPSNLSI-WNFGSLLGLCLIVQILTGIFLAMHYTADI TLAFSSVRHICRDVKYGWLLRKVHAKGASLFFICMYCHIGRGLYYGSYKKIET-KVGVIL FLVTILTAFMGYVLV-GQMSF-AATVITNLVSAIPYMGTTIVQ----------------- -LHFLFPFIIAALAIIHLVFLHNRGANNPVGLKSNYDKAPFHIYYTTKDTVGFILLIAAL FSLALLFPGALKDPENFIPANPLVTPPHIQPE-YFLFAYAILRSIPNKLGGVIALVAAIL VLFLMPLLNTSKKESNSFRPLSQAAF-LLVATFLILT-IGRQPVEYPYVLLGQVASVIYF SLFIFGFPLVSSIENKIIFS- >S purpuratus MAAPLRKEHPIFRILNSTFVDLPLPSNLSIWWNSGSLLGLCLVVQILTGIFLAMHYTADI TLAFSSVMHILRDVNYGWFLRYVHANGVSLFFICMYCHIGRGLYYGSYNKIETWNVGVIL FLVTILTAFMGYVLVWGQMSFWAATVITNLVSAIPYIGTIIVQWLWGGFSVDNATLTRFF PFHFLFPFIIAALAVIHLVFLHNSGANNPFAFNSNYDKAPFHIYFTTKDTVGFILLVAAL FSLALLFPGALNDPENFIPANPLVTPPHIQPEWYFLFAYAILRSIPNKLGGVIALVAAIL VLFLMPLLNTSKNESNSFRPLSQAAFWLLVAHLFILTWIGSQPVEYPYVLLGQVASVLYF SLFIFGFPIVSSIENKIIFS- >L variegatus MAAPIRKEHPIFRILKGTFVDLPLPSNLSI-WKFGSLLGLCLIVQILTGLFLAMHYTADI TLAFSSVRHICRDVNYG-LLRKVHAKGASLFFICMYCHIGRGLYYGSYKKVET-NIGVIL FLVTILTAFMGYVLV-GQMSFWAATVITNLVSAIPYIGTTIVQ--LGGFSVDKATLTRFF AFHFLFPFIIAALAVIHLVFLHKRGANNPVGLKRNYDKAPFHIYYTTKDTVGFILLITAL FSLALLFPGALKDPENFIPANPLVTPPHIQPE-YFLFAYAILRSIPNKLGGVIALVAAIL VLFLMPLLNTSKKESNSFRPLSQAAF-LLVATFFILT-IGAQPVEYPYVFLGQVASVLYF SLFIFGFPLVSSLEKKIIFS- >M musculus -MTNMRKTHPLFKIINHSFIDLPTPSNISSWWNFGSLLGICLMVQIITGLFLAMHYTSDT MTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTFMETWNIGVLL LFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFF AFHFILPFIIAALAIVHLLFLHETGSNNPTGLNSNADKIPFHPYYTIKDILGILIMFLIL MTLVLFFPDMLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSIL ILALMPFLHTSKQRSLMFRPITQILYWILVANLLILTWIGGQPVEHPFIIIGQLASISYF SIILILMPISGIIEDKMLKLY CYTC >H sapiens -----------MGDVEKGKKIFIMKCSQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGYSY TAANKNKGIIWGEDTLMEYLENPKKYIPGTKMIFVGIKKKEERADLIAYLKKAT------ NE >H glaber -----------MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFSY TDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFTGIKKKGERADLIAYLKKAT------ NE >M brandtii -----------MGDVEKGKKIFVQKCAQCHTVEKGGNHKTGPNLHGLFGRKTGQAPGFSY TDANKNKGITWGEATLMEYLENPKKYIPGTKMIFAGIKKSAERADLIAYLKKAT------ NE >S franciscanus LDMAANDDVIPPGDPEKGAEIFREHCAGCHDIDKSGEHRAGPNLMGLWGRKTGSAEGFKY TEANKNKGITWSMDTLWVYLENPKAYIPGTKMVFAGLKKTKERADLIAYLKEKTTGNYHK DD >S purpuratus MGKEPKATTPSVGDPDKGAKIFKVKCTQCHVIDNSGKHKQGPNLMGLWGRKTGSAEGFKY TEANKNKGITWGLDTLWVYLENPKAYIPGTKMVFAGLKKTKERADLIAYLKEKTTGNYTK DD >L variegatus SAEGNIDWSPVMGDPEKGAIIYAEICAQCHTIENSRKHKQGPNLSGIWGRKTGQAPGFKY TDANKNKGITWGLDTLWIYLENPKAYIPGTKMVFAGLKKTKERADLIAYLKEKTTGNYHK DD >M musculus -----------MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAAGFSY TDANKNKGITWGEDTLMEYLENPKKYIPGTKMIFAGIKKKGERADLIAYLKKAT------ NE DAF9 >H sapiens ---------------------------------------------------------MAL LLLLFLGLLGLWG----------------------LLCACAQDPSPAARWPP-GPRPLPL VGNLHLLR-LSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADR PPIAIFQLIQ-----RGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCL SGQLDG--YRGRPFP-LALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGS PGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDP---------VC SYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRV QEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPH-VPRCTAADTQLGGFLLPK GTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANG-HFVKREAFLPFSAGR-RVCVGERLA RTELFLLFAGLLQRYRLLPPPGVS-----PASLDTTPARAFTMRPRAQALCAVPRP---- ------ >H glaber -----------------------------------------------------MLASGLP LVALLVFLSIVI-----------------------LMSVW-QHRRLHGKLPP-GPTPLPF IGNYLQLNTEQM-YNSIMKIKEQYGPVFTIHLGPRRVVVLCGYDAVKEALIDQAEEFSGR GKQATFDWIF----KGYGVAFSSWERAR-HLRRFSISTLRDFGMGKRGIEERIQEEIGFL IESFRE--TQGAFIDPTFYLSRAVSNIISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTAT STGQLYEMFYS--VMKYLPG-PQQQAFKELQGLENFIVKKVEQNQRTLDPS--SPRNFID SFLIRIQKNSNAE-----FHMKNLVMTTLSLFFAGTETVSTTLRYGFLLLMKHPDVEAKI HEEIDRVIGRNRHPMFEDKAKMPYTDAVIHEIQRFGDMIPMNLAHSVTKDTKFRNFLLPK GTEVFPVLGSVLRDPKFFSNPQDFHPQHFLDEKGQ-FKKNDAFVPFSLGK-RYCLGEGLA RMELFLFLTSILQNFRFK-SPQARQDIDVSPKLVGFATI---PQNY--TMSFLPR----- ------ >M brandtii ---------------------------------------------------------MDL FTVLAICLSCLI-----------------------LLFLW-NRSYAQGKLPP-GPTPLPV VGNILQINMKNF-NESLRKLAEVYGPVFTVYVGTQPTVVLHGYAAVKEALIDRGEEFAGR GSFPVIDYLS----RGLGVVFSNGDIWK-HTRRFSLTVLRNMGMGKKTIEDRIQEEALCL VEALKK--TNASPCNPSLLLGCAPCNVICSVIFQSRFEYSDEKFLTLLHYFNENLRIIST TWIQLYNAFPY--LMHYLPG-SHNEFFNNFTEQKKFILEQIKEHQESLDLN--NPRDFID YFLIKMEKEKHNE--QSVFTMDNLITTIWDMFSAGTETTATTLKYGLLLLLKHPEVTAKV QEEIDRVVGRERSPCMQDKSHMPYTDAVIHEIQRYIDLVPNNLPHLVNQDIKFRGYFIPK GTAIVTSLTSLLHDDKEFPNPDQFDPGHFLDESGN-FKKSNNFMPFSAGRKRVCVGEGLA RMELFLLLTHILQHFTLK-PLVDPKDIDTSPVVNGFGSV---PPSY--ELCFVPV----- ------ >S franciscanus ---------------------------------------------------------MDF GISLTTFLLGMVTFL------------------VTFIMVRSGKSKKYKNLPPRGPREWPV LGSLPSLAGKDMPHEAIADLAKKYGPIFSMRRGSFYFVVLNDRESIKQALVKSGEFFSDR PKIAMIEHIA----EGKGKVAIYTSPAQIEQRKFTLSVFRSLGVGKKSYEDTIAAEMAQL GKAIEE--KKGKPFDPNVLIGQAVANVICSIIFGTQYKYNDTDFQHVLAASYRIFEI--A EIAGLFNFLPF---LRFLPGSGVKRMVALQAIFDKYMKPLVWKVNEEQEKSRRSPTCYVE MYTEQMIEAERQTPGPHSFSKLNLKSAIADLFIAGTETTTTTLKWAILYMMAYPEVQSRV QAEIDHVVGRERLPTLNDRKNLPYTEATLMEVLRYRPVAPLGVPHATTQDTVLGGYTIPK GTIIIPNLWAVHHDPKEWDDPDKFNPDRFLSEDGKTVVKNEALIPFSIGR-RKCLGEQLA KMELFLFFTHLLQRFEFKLPPGAP-----PPSMRGRNGITMNPEPY--KICAIPRRIKSN IKN--- >S_purpuratus ---------------------------------------------------------MDF GISLTTFLLGMVTFL------------------VTLMIVWSRTGRTYANLPPKGPPEWPI IGSLLSLAGEHPPHQILANMAKKYGPIFSMQMGSFYAVVLSDYSLIKQAFAKSGDDFSDR PKIAMIEHLA----EGKGLISGYNSPAQIEQRRFTFSALRSLGMGKFRMEETISEEIQHL IKSFTE--RNTQPFIPFHDITVSVSNVICWLNFGKRFEYNDDDFKGVLEALFGIVEI--T EIGGVFNFLPF---LRFLPGSGLKKCFKHKAIFDKHMYPLIRKIKQSYDDKFESAECYIH MYADKIAEAAKQNIVPNLFNDGNMVLAVADLFVAGTETTATTLKWALLYMVVNQDVQKRV QEELDRVVGVDRLPSLLDKPNLPYTEATLLEIQRKASIVPLGVPHAPVQDTILYGYDIPK GTVVLPNLWAIHHDPNLWKNPDEFNPDRFLKPDTKHVVQREELIPFSIGR-RRCIGEELA KVELYLFFTHLLCRFHFILPPGAP-----QPTMEGRSLATFVPHDY--SLCAIPRCRDKD FEES-- >L variegatus ---------------------------------------------------------LRR GSLIFKIMLGLVTFL------------------VTLMLIRSRTRRTQANFPPKGPPEWPI IGSLLSLAGEHPPHETYANMAKKYGPIFSMQMGSFYAVVLSDYSLIRQAFAKSGEEFSDR PKITMIENLV----QGKGLIVSYSSPVQTEQRRFTLSALRSLGMGKKSYEETIAEEARQL AEAIEE--KRGKPFDPFHLIVVAVSNIICWIVFGRRYKYDDAEFKRILESVFESFEI--A EMAGLFNFLPF---LRFLPGSGVKRMLELRAIFDKYMKPMVWKISEEQEKSRRSPTCYVE MYTEQMIEAEQETPGPHTFDDTNLLQSIADLFFAGTETTATTLKWAILLMAAHPEVQSRV QAEIDDVVGRDRLPTLSDRKNLPYTEATLMEVMRFRPVLPLGVPHMTSADVKLGGYDIPK GTIVLPNLWAVHHDPKLWKDPEEFNPDRFLSEDGKTVVKNEALMPFGIGR-RDCLGEQLA KMELFLFFTNLLQRFEFRLPPGAP-----PPSMFGHNGATLNPKPY--KICAIPR--STS LAD--- >C elegans ---MHLENRVLSSVLDYASKFYKRMSSLVFFSANSIQVQMNISQSSWIKCRDWMAFALSH HIIMGIYLLILRNFLPQVVPDFEWQHYFMRVFIVHIIYIIISYFIRITRYPP-GPPPMAV FGNSPFVNILTP-EQTFLEYREIYGPIFTLHL-SQPTIILAEYKTIQEALVKNGQQTSGR SSAESFVLFTGDRLNGDGVILAMRQKWK--DMRHEISRFMNKWYGA-PMDELVLHHTRCL EQELAKIAETKSLIDLRDPLAGAIANVIQQITIGRNYMYQDQEFQTQLRDINAVVKEIMT AEVFFVNCYPW---LRYLPE-GILRKWTNYKRSGFRLQQWFRTILEEHHVN-RHQGDFM- SHMIDLQESKQEQ-----FRDLSIILTCGDMWTGGMETTVTTLRWGIIYLLNNPEVQAKC QMEILDVFGNDI-PDMGKMNQTPYVRATLSEIQRLANVLPWAIPHKTIEECNIGGYDIPV NTEIIPALGAVLFDPNVFESPKQFKPERFLDEEGK-YRVMEEFRPFGLGP-RVCLGERIA RTELYLIFASLLQNFRFYLNRGDP--IPVAERVIG--GITAPPKPYATRVEYLGNRLIN- ------ >M musculus ---------------------------------------------------------MDP ILVLVLTLSCLF-----------------------LLSLW-RQSSERGKLPP-GPTPLPI IGNILQIDVKDI-CQSFTNLSKVYGPVYTLYLGRKPTVVLHGYEAVKEALVDHGEEFAGR GRFPVFDKAT----NGMGLAFSKGNVWK-NTRRFSLMTLRNLGMGKRSIEDRVQEEARCL VEELRK--TNGSPCDPTFILGCAPCNVICSIIFQDRFDYKDRDFLNLMEKLNEITKILSS PWLQICNTYPA--LLDYCPG-SHKQFFKNYASIKNFLLEKIKEHEESLDVT--IPRDFID YFLINGGQEDGNQ--PLQNRLEHLAITVTDLFSAGTETTSTTLRYAILLLLKYPHVTAKV QEEIEHVIGKHRSPCMQDRSRMPYTDAMIHEVQRFIDLIPNSLPHEVTSDIKFRNYFIPK GTTVITSLSSVLHDSTEFPNPEKFDPGHFLDENGK-FKKSDYFIPFSTGK-RICAGEGLA RMELFLFLTSILQNFNLK-PLVHPKDIDVTPMLIGLASV---PPAF--QLCFIPS----- ------ >SIG ~~~--------------------------------------------------------- ------------------------------------------------------------ ----------------+------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -- EXO1 >H sapiens MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCM KFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQLLREGKVSEARECFT RSINITHAMAHKVIKAARSQGVDCLVA---PYEADAQLAYLNKAGIVQAIITEDSDLLAF GCKKVILKMDQFGNGLEIDQARLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAK ACKVLRLANNPDIVKVIKKIGHYLKM-NITVPEDYINGFIRANNTFLYQLVFDPIKRKLI PLNAYEDDVDPETLSYAGQ---YVDDSIALQIALGNKDINTFEQIDDYNPDTAMPAHSRS HSWDDKTCQKSANVSSIWHRNYSPRPESGTVSDAPQLKENPSTVGVERVISTKGLNLPRK SSIVKRPRSAELSEDDLLSQYSLSFTKKTKKNSSEGNKSLSFSEVFVPDLVNGPTNKKSV STPPRTRNKFATFLQRKNE----ESGAVVVP----------------------------- ------------------------------------------------------------ ---GTRSRFFCSS-DSTDCVSNKVSIQPLDETAVTDKENN--LHESEYGD---------- ---------------------------------------------------------QEG KRLVDTDVARNSSDDIPNNHIPGD-----------------------------------H IPDKATVFTDEESYSFESSKFTRTISPPTLGTL------RSCF----------------- -SWSGGLGDFSRT--PSPSPS--------------------------------------- ----------TALQQFRRKSDSPTSLPENN--MSDVSQLKSEESSDDESHPLREEACSSQ SQESGEFSLQSSNASKLSQCS----------SKDSDSEE------------SDCNIKLLD -------SQSDQT---SKLRLSHFSKKDTPLRNKVPGLY--KS----SSADSLSTTKIKP LGPARASGLSKKPASIQKRKHHNAENKPGLQIKLNELWKNFGFKKDSEKLPPCKK--PLS PVRDNI--QLTPEAEEDIFNKPE-CG---------------------------------- ----------------------------------------RVQR-----AIFQ------- ------------------------------------------------------------ -------- >H glaber MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDKYVGFCM KFVNMLLSHGIKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARECFT RSINITHAMAHKVIKAARTLGVDCLVA---PYEADAQLAYLNKAGIVQAIITEDSDLLAF GCKKVILKMDQFGNGLEIDQSRLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAK ACKVLRLANNPDIEKVIKKIGHYLKM-NITVPEDYIKGFIRANNTFLYQLVFDPIKRKLV PLNAYEDDIDPETLTYAGQ---YIDDSIALQIALGNKDINTFEQIDDYNPDTAMPSLLRS HSWDDKACQKSPAVNSIWHRNYRPTLEMNIVSDVTRLEEKPSTVGMKQVISTKGLNLPRK SSLVKRPRSEELSEDDLLNQY-FSFAKKTKKNGCENNKSLNSSEMFVPDLRNGTIHTESL NTPPRTRNKFATFLQRKNE----ESGAVVVP----------------------------- ------------------------------------------------------------ ---GTRSRFFSSSLDSADCVSKQTSSQPLSETAVREKVTD--LSESDCPD---------- ---------------------------------------------------------LEG KKLVDTQ----------AAHNSSG-----------------------------------E SPDDVTVFAGEEPQFVRTGTFTRTISPPTLGTL------RSCF----------------- -SWSGSLREFSNSLRTSPKPS--------------------------------------- ----------TMSQQFQRKSGSPSSLPEDTN-MSDMSQSKSDESG-DEAQPLREMDLSSQ SQKSMEFSPHSLNASELSQPS----------SKDSDSEE------------SDCNNKSLH -------NQGNQN---SKQHLSHFSRKETLLRNKVPGLS--KS----SSVDCLSATKIKA LVPARVSGLSRKPASIQRRNHRNAENKPGLQIKINELWKNFGFKKDSEKLVSYKK--PLS PVKDNI--QLTPEAEEDIFNKPE-CA---------------------------------- ----------------------------------------HVQR-----AIFQ------- ------------------------------------------------------------ -------- >M brandtii MGIQGLLQFIKDASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDK------ ----------------------------------RRQANLLKGKQLLREGKVSEARECFT RCVNITHAMAHNVIKAARAQGVDCLVA---PYEADAQLAYLNKAGIVQAIVTEDSDLLAF GCKKVILKMDQFGNGLEIDQARLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAK ACKVLRLANNPDIVKVIKKLGHYLKM-NITVPEDYIKGFIRANNTFLYQLVFDPIRRKLV PLNDYGDDIDPAALSYAGR---YIDDSIALQIALGNKDINTFEQIDDYNPDTAMPAQSRS RSWDDNTSQKPSGVHSIWHRNYCPRPELAPVPGATRLKENPSTAGREQ------------ ----------ELSEDDLLSQYSLSFTKKTKKDGCEGSTSLNSSKMLMPDPVDGTTIKKTL STPPTTRNKFAAFLQRKNQ----ESGAVVVP----------------------------- ------------------------------------------------------------ ---GTRSRFFCNSLDSMDCVSKKASPQPLDETADTDKKTN--LNESDCLDDKKVVDLNES DCLDDKVVDLKESDCLESKMLGELNEPDCLESKKVVDLNESDCLESKKVVDLNESDCLES KKVVDLNQSDCLESKKLVDLNQSDCLESKKLVERNGAHTP-----------------SAQ TPDGATVIADEESPSFKTIRFTKTISPPTLGTL------RSCF----------------- -SWSGSLGDFSRT--PSPSPS--------------------------------------- ----------TALHQFRRKGDSPSSLPGST--VSDVSQVKGDASG-DEALPVHELSWSSQ SQESAELSPHSLSASTLPQPS----------RKDCSPEVPGLYRSSSLDSLSTTKIKALV PARVSGLSKRPAR---AQKRKHHNAENKPGLQTKINELW--KNFGFKNSLDSLSTTKIKA LVPARVSGLSKRPARAQKRKHHNAENKPGLQTKINELWKNFGFKKDSEKLPSCKKPDPLS PVKDNI--QLTPETEEDIYHKPESCGAGGTRLVQKLEEVEKNQERTAVALEAARAETEML EQQEGQYHKDLGELQWQQQELQDELLSLEDRLLYPQTQLARLKRTNAFKATFEICCDGPL AIINSFRLGCVPTVPVSWWEINAAWGHTALLLMALSNTVGLEFQRYQLIPPADHSYLKSL TEDPVELP >S franciscanus --------FF-----------------------------LLCS-----------YVRYCL KYVNMLRALDIKPVMVFDGRNLPAKAGVEDSRREVNIIVMFY---------------HIF QSLSKQFFIFSPMKQAVRSLGVDCIVA---PYEADAQLAYLEKNGFVQAVITEDSDLIAF GCKQVIVKLDLAGNCMDVDSSRLNVAMKIGEKFTPEKFRYMCIVAGCDYLASLPGIGIGK ARKLFQLTANPDITQVIKRMATTLKMKSTTVTPEYQEGFQQANNTFLYQLAFDPQKKKLQ PLTPYSPEVTPSTLTYAGKVTRYCHEPQSKDKQLMIIETCIAKLI--FQP---------- --YDKKT---PRHLLSIWHKDFQPGPGLGCLKQDHI--EREGTKGKEITMYFMLFTNLLM FCV-------EEEEVGAPSDYQLSSMYTTK--GQLDGNQWMESQRVIPETPDKDVVE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------QSPSKIPSDVS-SPDTDDVSLNSSTASSPSPPPASSSSSS LQTTKPFGVATASQSNNNAHS--------LWVGSKGATSGYFGGGEREMSQGVVRQKGMM QEEEEWENTPPGRGGVSPYNRRRNRNLSGKRHNQFIPAC-TTSIHSKCAIFPNALEQSAF LGKCKASGLSKKRRSSGKTKPDAT---PKGQTSLLAF---MAKPKLRDPLISQKGVSPLS PNRANLCTDLTPETEGSLLSRQGRGF---------------------------------- ----------------------------------------TTKR-----HIFE------- ------------------------------------------------------------ -------- >S purpuratus MGIQGLLPFLKEASEPIHIRKYKGYTVGIDSYCWIHRGAVACATQLAKGEPADHYVRYCL KYVNMLRALDIKPVMVFDGRNLPAKAGVEDSRRERRETYSKKGRQFLREGKASEARDCFV KCINVTPEMALNVMKAVRSLGVDCIVA---PYEADAQLAYLEKNGFVQAVITEDSDLIAF GCKKVIVKLDLAGNCMDVDSSRLNVAMKIGEKFTPEKFRYMCIVAGCDYLASLPGIGIGK ARKLFQLTANPDITQVIKRMATTLKMKSTTVTPEYQEGFVQANNTFLYQLAFDPQKKKLQ PLTPYSPEVTPATLTYAGK---YVDEVKAYQMALGNINFDTMERIADFNPMVNKP----- --YDKKT---PRHLLSIWHKDFQPGPGLGCLNQDHI--EREVTKGKEITVEVK------Q RLIQKKRQRDEEEEVGAPSDVQLSSMYTTK--GQPDGNQWMESQRVIPDTPDKDVVEE-- EMKPSKRNRFATKLTSRNRANIVNSGEVVTSRFFQPKKLDVSSEKQQQIPDNNKLKIEEK ENQRVSMNTSGLLEGIVDIEMEQEKQFKMEDDDEDDIEDVIEIKLKETVSGSQSRQTHVT KSIDALQRFQRSSSASVLVKTERNLTSSSLSNSVKPRTALSSTHQSEDIPDSQKSVIEIE SSQDSVCSTRSVDTCSQSSSLSSSQRQGTPRPRSAFSWSRKKELQGKDKGSKQPTQGTLS GFVFKPTHRSKAMPRHTAVGVQDGNSQGNSLSRRDSYEMPCSPVSQNSSSQLLRLSLTSS IPGSMDMLRLGEDVTFMDSQSSNLTESQNTSSITLTSDQTSQL----------------- -IDNTDLEDVSPPIPPLPQLP--------------------LQIHLSNGEEEEEEKGEMM EGIRRTGLSRKRKKTFSSEEQSPGKIPSDVS-SPDTDDVSLNSSTASSPSPAPA-LSSSS LQTTKHFGMATASQSNKDADS--------LRVGGRGATSCYFGGGEREMSQGVVRKKGMM QEEEEWENTPPGRGGVSPYKGRRNRNLSGKRHNQGPKAAFMNDENQQNSSNSEPKKQSAF LGQCKASGLSKKRRSSGKAKPDAT---PKGQTSLLAF---MAKPKTKDPLISQKGVSPLS PNRANLCTDLTPETEGSLLSRQGRGF---------------------------------- ----------------------------------------TTKR-----HIFE------- ------------------------------------------------------------ -------- >L variegatus MGIQGLLPFLKEASEPIHIRKYKGYTLGIDTYCWIHRGAVACATQLAKGDPADQYVRYCL KYVNMLRALDIKPVMVFDGRNLPAKAAVEDSRRERRETYSRKGRQFLREGKASEARDCFV KCINVTPEMALDVMKVILHGKGSCNVEVSDSYQFSCLFVHFSQCR--QSI----SSVISL SILQVIVKLDLAGNCMEVDSSRLNIAMKIGEKFTPEKFRYMCIIAGCDYLASLPGIGIGK ARKLFQLTVNPDIKQVIKRMATTLKMKSTTVTPEYMEGFQQANNTFLYQLAYDPNKKKLQ PLTPYPPEVGPSMLTYAGK------VEISFSHSCHSSNYCIFIIEFYIKHICHLPIY--- --HDKKT---PRYLLSIWHKDYQPGPGLGCLDQDHI--EREGTKGKEITVEVK------Q RLIQKKRQREPIEPYYIYQKY-IMQRYANKKNFAINADIKNLCIYIIQHPMFASSHH--- CLKPAKRNRFATKLTSKKRANIVNSGEVVTSRLYHAKN---------------------- -----------------PITLESRIISGIHSAIYLLCHMVVSEKAKLLQEYCSKMKCMKI WSLASKPRYIQIALHSMFASSPHYMIRIHMVTVSTPCISSLIRQEDNNMPLFTYLMTQVH RQCNIAIIISKCNGYFLPTLFFILDFSANLILRIQWKISRETLHVKQMLVFVH----TEQ RPVVRNALNKEMKGTQIHNTGLSDHRQTY----------------------------MSI IPSISNIVIFVITKKIVSVVFTKVMLKSSLPTYFDARINNRIFPLHVIIWMAFFIDQYKS SNWSASSVVVFSN--PTPNMPLSMKTWVSKLYFFLYLFDYTRNQRRHCYLFILLKKSRFF SLVVTDLFFFNIFQKIPSFDQSPTKVRSEVS-SPDTDDVSLPSSTTSSPSPPPA---SAS LNTTKVIAMETASQSKDSNHNDAVSGGLGLGTGDGPRSSGHSRGGETEASSGVVGKKGVV MQEEEWENTPPGRGGVSPYKRHRNRSLSGRRHQVVTRAS-SISYTFSVHHQSYFTQQSAF LGKCKASGLSKKRRLSGKGKPEAT---PKGQTSLLAF---MAKPKTRNPLISQKGVSPLS PNRANIHADLTPETDGSLLSRQGRAL---------------------------------- ----------------------------------------ATKR-----HIFE------- ------------------------------------------------------------ -------- >M musculus MGIQGLLQFIQEASEPVNVKKYKGQAVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCM KFVNMLLSYGVKPILIFDGCTLPSKKEVERSRRERRQSNLLKGKQLLREGKVSEARDCFA RSINITHAMAHKVIKAARALGVDCLVA---PYEADAQLAYLNKAGIVQAVITEDSDLLAF GCKKVILKMDQFGNGLEVDQARLGMCKQLGDVFTEEKFRYMCILSGCDYLASLRGIGLAK ACKVLRLANNPDIVKVIKKIGHYLRM-NITVPEDYITGFIRANNTFLYQLVFDPIQRKLV PLNAYGDDVNPETLTYAGQ---YVGDSVALQIALGNRDVNTFEQIDDYSPDT-MPAHSRS HSWNEKAGQKPPGTNSIWHKNYCPRLEVNSVSHAPQLKEKPSTLGLKQVISTKGLNLPRK SCVLKRPRNEALAEDDLLSQYS-SVSKKIKENGCGDGTSPNSSKMSKSCPDSGTAHKTDA HTPSKMRNKFATFLQRRNE----ESGAVVVP----------------------------- ------------------------------------------------------------ ---GTRSRFFCSSQDFDNFIPKKESGQPLNETVATGKATTSLLGALDCPD---------- ---------------------------------------------------------TEG HKPVDAN----------GTHNLSS-----------------------------------Q IPGNAAVSPEDEAQSSETSKLLGAMSPPSLGTL------RSCF----------------- -SWSGTLREFSRT--PSPSAS--------------------------------------- ----------TTLQQFRRKSDPPACLPEASAVVTDRCDSKSEMLG-ETSQPLHELGCSSR SQESMD-SSCGLNTSSLSQPS----------SRDSGSEE------------SDCNNKSLD -------NQGEQN---SKQHLPHFSKKDGLRRNKVPGLC--RS----SSMDSFSTTKIKP LVPARVSGLSKKSGSMQTRKHHDVENKPGLQTKISELWKNFGFKKDSEKLPSCKK--PLS PVKDNI--QLTPETEDEIFNKPE-CV---------------------------------- ----------------------------------------RAQR-----AIFH------- ------------------------------------------------------------ -------- >SIG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------+------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ FOXO1 >H sapiens MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFSQSNSATSSPAPSGSAAANPDAAAGLPS ASAAAVSADFMSNLSLLEESEDFPQAPGSVAAAVAAAAAAAATGGLCGDFQGPEAGCLHP APPQPPPPGPLSQHPPVPPAAA---GPLAGQPRKSSSSRRNAWGN----LSYADLITKAI ESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV--QNEGT GKSSWWMLNPEGGKSGKSP--RRRAASMD-NNSKFAKSRSRAAKKKASLQSGQEGAGDSP GSQF-SKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGEGDVHSMV YPPSAAKMASTLPSLSEISNPEN----MENLLDNLNLLSSPTSLTVSTQSSPGTM-MQQT PCYSFAPPNTSLNSPSPNYQKYTY----GQSSMSPLPQM-PIQTLQDNKSSYGGMSQYNC APGLLKELLTSDSP-PHNDIMTPVDPGVAQPNSRVLGQNVMMGPNSVMSTYGSQASHNKM MNPSSHTHPGHAQQTSAVNGRPLPHTVSTMPHTSGMNRLTQVKTPVQVPLPHPMQMSALG GYSSVSSCNGYGRMGLLHQEKLPSDLDGMFIERL----DCDMESIIRNDLMDGDTLDFNF DNVLPNQSFPHSVKTTTHSWVSG >H glaber MAEAPQVVEIDPDFEPLPRPRSCTWPLPRPEFNQSSSATSSPAPSGGTTGNPDAAAGLAP APAAAVSADFMSSLSLLEESEDFPRAPGSVAAVVAAAAG----GGLCGDFQGPEAGCLHP APPL-PPPGPLPQHPPVPAAAAAAAGALAGQPRKSSSSRRNAWGN----LSYADLITKAI ESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV--QNEGT GKSSWWMLNPEGGKSGKSP--RRRAASMD-NNSKFAKSRGRAAKKKASLQSGQEGAGDSP GSQF-SKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGDGDVHSLV YPPSAAKMASTLPSLSEISNPEN----MENLLDNLNLLSSPTPLTVSTQSSPGSM-MQQT TCYSFAPPNTSLNSPSPNYQKYTY----GQSSMSPLPQM-PMQTLQDNKSSYGGLNQYNC APGLLKELLTSDSP-PHNDIMSPVDPGVAQPNSRVLGQNVIMGPNSVMPTYGNQASHNKM MNPTSHTHPGHAQQTSAVNGRALPHPVNTMPHTSGMSRLTPVKTPLQVPLSHPMQMSSL- GYSSVSSCNGYGRMGILHQEKLPSDLDGMFIERL----DCDMESIIRNDLMDGDTLDFNF DNVLPNQSFSHSVKTTTHSWVSG >M brandtii ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------MLNPEGGKSGKSP--RRRAASMD-NNSKFSKSRGRAAKKKASLQSGPEGAGDSP GSQF-SKWPASPGSHSNDDFDNWNTFRPRTSSNASTISGRLSPIMTEQDDLGDGDVHSMV YPPSAAKMASTLPSLSEISNPEN----MENLLDNLNLLSSPPSLTVSTQSSPGAM-MQQT PCYSFAPPNTSLNSPSPNYQKYTY----GQSSMSPLPQM-SMQTLQDNKSSYGGMNQYNC APGLLKELLTSDSP-PHNDIMAPVDPGVAQPNSRVLGQNVLMGPNPVMPSYGSQASHNKM MNPSSHSHPGHAQPTSVVNGRALPHAVNTMPHTSGMNRLAPVKTALQVPLPHPMQMNALG GYSSMSSCNGYGRMGILHQEKLPSDLDGMFIERL----DCDMESIIRNDLMDGDTLDFNF DNVLPNQSFPHSVKTTTHSWVSG >S franciscanus WARPNKTL----------RDRVCRGQRKWEEVCQ-------PYPRRGPRIRFCHHKLLII LTPHSVPPS--------------------------------------------------- -----STEETRDTKPILPLEGGENRELSTPSSQR-NGPRRNAWGN----LS-ADLITKAI QSAPDQRLTLSQIYDWMVKNVPIFKDKGDSNKT--------------RPTCLA--TDWSK EGIGFWLFQKHCSCTSIKPFCCKPGWKITLVGSRFTSDMRRSRARPWLLSMPWTRPATLS LDALTSSWRTT-NPSSRPLVTAPTTSRTLAFATKRSRFGTASGLFTFQASAMLLPMPSPV IPLVSLNSFLSLMMSRTFGTPSTPFHIHPCIIDSL-LLSAPLLTTFRRCAQQMPHHQPKS SGLSLRMTSVWPQQATPPCPGCPSSRRASPTNATPSRQTSASTTSFES---TSLASMVLC IV-------------IAWSSRPPFEAACCRPYTLHTRASRKCAPEQNLPSFGQAPQLSSR CGP-------DALPATACRPLSLPH-----PHPTGLPGLPIPVHCCLLSFPGPL------ ----------LGHCGQVQQ--LANSRGGCCWGQWTHCCPAPYLCHVRHQAVIWGTIHVAP DILPPLGCTPSCFFSCL------ >S_purpuratus ------MVDNDPDFEPQARPRSCTWPLRRPDFLDSK-----PGQPGNAAGAPPVDHAHSA LSPAVLA----------------------------------------------------- -------EEPLDIKPVLPLEGGENRELSTPSSQRRNGSRRNAWGN----LSYADLITKAI QSAPDQRLTLSQIYDWMVKNVPFFKDKGDSNSSAGWKNSIRHNLSLHSRFVRV--QNEGT GKSSWXMINPDA-KPGKSS--RRRASSMDTTNSKFERKRGRVKKKVLEERAKWGNTSPTP ------KLEGEEGASPLPFNLATTDFRSRASSNASS-CGRLSPIMTTHP---EIDMHDNE VPPMSPIPFQDLPPSQAYDSPDP-----YQSTDQLAKLAKAMTLDSSLSVEPAIRHTHNN GGYLFSPQSYSGSDMSPVHSNSPYYSQQGTPAVSPLGQCSPMQELPPSQ--YGMQRSFTN LIHENESIIPQDPMFAQSAVLRQQQSPRPMPSCREESMNQHTSPHRLMPSSMNQGSNLAM L-----LNNGHNTHTTSHHHHPQPYPNGGTPHHVHPHHIHP-----HIHHHHP------- --------------GMVHVDRFPSDLESVQIDPLKGWSDLDVETILRNEQDLTEGPDASF DNIGTIGTTATTM--AAPSWVH- >L variegatus --NTFKMI---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------YCRDEYISCII RSTIN--LQIEDQFSFLLYKC--------------------------AQLCCS------- ------------------------------------------------------------ ----------------------------------------------------QIDLHVLV ------RLSSSQCTISILKRNTD---------------------------------LNTY TCFIF----------------------------------------------YLLLHLICC A--------------------------------------------KFLHNY--------- -----------------------------------LSKISISSSSLAFSMQNS------- ---------------------------------------------IRHNL----SLHSRF VRVQNEGTGKSS----------- >M musculus MAEAPQVVETDPDFEPLPRQRSCTWPLPRPEFNQSNSTTSSPAPSGGAAANPDAAASL-- ASASAVSTDFMSNLSLLEESEDFARAPGCVAVAAAAAAS----RGLCGDFQGPEAGCVHP APPQPPPTGPLSQPPPVPPSAAAAAGPLAGQPRKTSSSRRNAWGN----LSYADLITKAI ESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIRV--QNEGT GKSSWWMLNPEGGKSGKSP--RRRAASMD-NNSKFAKSRGRAAKKKASLQSGQEGPGDSP GSQF-SKWPASPGSHSNDDFDNWSTFRPRTSSNASTISGRLSPIMTEQDDLGDGDVHSLV YPPSAAKMASTLPSLSEISNPEN----MENLLDNLNLLSSPTSLTVSTQSSPGSM-MQQT PCYSFAPPNTSLNSPSPNYSKYTY----GQSSMSPLPQM-PMQTLQDSKSSYGGLNQYNC APGLLKELLTSDSP-PHNDIMSPVDPGVAQPNSRVLGQNVMMGPNSVMPAYGSQASHNKM MNPSSHTHPGHAQQTASVNGRTLPHVVNTMPHTSAMNRLTPVKTPLQVPLSHPMQMSALG SYSSVSSCNGYGRMGVLHQEKLPSDLDGMFIERL----DCDMESIIRNDLMDGDTLDFNF DNVLPNQSFPHSVKTTTHSWVSG FOXO3 >H sapiens MAEAPASPAPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEE EDDEDDEDGGGRAG-SAMAIGGGGGSGTLGSGLLLEDSARVLAPGGQDPGSGPATAAGGL SGGTQA---LLQPQQPLPPPQPGAAGGSGQPRKCSSRRNAWGN----LSYADLITRAIES SPDKRLTLSQIYEWMVRCVPYFKDK------GDSNSSAGWKNSIRHNLSLHSRFMRVQN- -EGTGKSSWWIINPDGGKSGKAP--RRRAVSMDNSN-KYTKSRGRAAKKKAALQT----- --------APESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIM ASTELDEVQDDD-APLSPMLYSSS-ASLSPSVSKPCTVE-----LPRLTDMAGTMNLNDG LTENLMDDLLDNITLPPSQPSPTGGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLN SLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDP--LMSQASTA VSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGL SESSSLGSAKHQQQSPVSQSMQTLSDSLSGSSLYSTSANLPVMGHEKFPSDLDLDMFNGS LECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG >H glaber MAETSASPIPLSPPEVEVDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEE EDDEDDED-SGRTS-SAMAIGGG-GSGTLGSGLLLEDSARLLASGGQDFGSGPAPAVGAL SGGTQT---PLQPQQPLPAPQPGAAGSSGQPRKCSSRRNAWGN----LSYADLITRAIES SPDKRLTLSQIYEWMVRCVPYFKDK------GDSNSSAGWKNSIRHNLSLHSRFMRVQN- -EGTGKSSWWIINPDGGKSGKAP--RRRAVSMDNSN-KYTKSRGRAAKKKAALQT----- --------APESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIL ATTELDDVQDDD-APLSPMLYSSS-ASLSPSVSKPCTVE-----LPRLTDMAGTMNLNDG LADNLMDDLLDNITLQSSQPSPTGALMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLN SLRQSPMQTIQENKPATFSSMSHYGNQTLQDLLTSDSLSHSDVMMTQSDP--LMSQASTA VSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGL SDSSSLGSAKHQQQSLVSQSMQTLSDSLSGSSLYSASANLPVMGHEKFPSDLDLDMFNGS LECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG >M brandtii ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------MVRCVPYFNDK------GDSNSSAGWKNSIRHNLSLHSRFMRVQN- -EGTGKSSWWIINPDGGKSGKAP--RRRAVSMDNSN-KYTKSRSRAAKKKAALQT----- --------APESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIL AGTELDDVQDDD-APLSPMLYSSS-ASLSPSVSKPCTVE-----LPRLTDMAGTMNLNDG LADNLMDDLLDNIPLPPSQPSPAAGLMQRSSSFPYTTKGSGLGSPTSSFNSTVFGPSSLN SLRQSPMQTIQENKPATFSSMPHYGTQTLQDLLTSDSLSHSDVMMTQSDP--LMSQASTA VSAQNSRRNVMLRNDPMMSFAAQPNQGSLVNQNLLHHQHQTQGALSGSRALSNSVSNMGL SDSSSLGSAKHQQQSLVSQSMQTLSDSLSGSSLYSTSANLSVMGHEKFPSDLDLDMFNGS LECDMESIIRSDLMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG >S franciscanus WARPNKT---LRDRVCRGQRKWEEVCQP----YPRRGPRIRFCHHKLLIILTPHSVPPSS TEE--------------------------------------------------------- ----TR---DTKPILPLEGGENRELSTPSSQR-NGPRRNAWGN----LS-ADLITKAIQS APDQRLTLSQIYDWMVKNVPIFKDK------GDSNKT--------RPTCLATDWSK---- -EGIG---FWLFQKHCSCTSIKPFCCKPGWKITLVGSRFTSDMRRSRARPWLLSMPWTRP ATLSLDALTSSWRTTNPSSRPLVTAPTTSRTLAFATKRSRFGTASGLFTFQASAMLLPM- -PSPVIPLVSLN-SFLSLMMSRTFGTPSTPFHIHPCIIDSLLLSAPLLTTFRRCAQ---- -------------QMPHHQPKSSGLSLRMTSVWPQQATPPCPGCPSSRRAS----PTNAT PSRQTS------------ASTTSFESTSLASMVLC------------------------- ---------------IVIAWSSRPPFEAACCRPYTLHTRASRKCAP-------------- ------------EQNLPSFGQAPQLSSRCGPDALPATACRPLSLPHPHPTGLP------G LPIPVHCCLLSF------------------------------------------ >S purpuratus --------------MVDNDPDFEPQARPRSCTWPLRRPDFLDSKPGQPGNAAGAPPVDHA HSA-------------------------LSPAVLAEE----------------------- ----PL---DIKPVLPLEGGENRELSTPSSQRRNGSRRNAWGN----LSYADLITKAIQS APDQRLTLSQIYDWMVKNVPFFKDK------GDSNSSAGWKNSIRHNLSLHSRFVRVQN- -EGTGKSSWWMINPD-AKPGKSS--RRRASSMDTTNSKFERKRGRV--KKKVLEE----- --------RAKWGNTSPT--PKLEGEEGASPLPFNLATTDFRSRASSNASSC-GRLSPIM TTHPEIDMHDNEVPPMSPIPFQDL-PPSQAYDSPDPYQS-----TDQLAKLAKAMTLDSS LSVE--------------------------PAIRHTHNNGGY----------LFSPQSYS GSDMSPVH----------SNSPYYSQQGTPAVSP----------LGQCSP--MQELPPSQ YGMQRSFTNLIHENESIIP------QDPMFAQSAVLRQQQSPRPMPSCRE---------- -------ESMNQHTSPHRLMPSSMNQGSNLAMLLNNGHNTHTTSHHHHPQPYP----NGG TPHXVHPQC--------------------------------------------- >L variegatus -----------------------------------NTFKMIYCRDEYISCIIRSTINLQI EDQ---------------------------FSFLLYKCAQLCCS---------------- ----QI---DLHVLVRLSSSQ------------CT---------------ISILKRNTDL NTYTCFIFYLLLH-LICCAKFLHNYLSKISISSSSLAFSMQNSIRHNLSLHSRFVRVQN- -EGTGKSS---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------ >M musculus MAEAPASPVPLSPLEVELDPEFEPQSRPRSCTWPLQRPELQASPAKPSGETAADSMIPEE DDDEDDEDGGGRAS-SAMVIGGG-VSSTLGSGLLLEDSAMLLAPGGQDLGSGPASAAGAL SGGTPT---QLQPQQPLPQPQPGAAGGSGQPRKCSSRRNAWGN----LSYADLITRAIES SPDKRLTLSQIYEWMVRCVPYFKDK------GDSNSSAGWKNSIRHNLSLHSRFMRVQN- -EGTGKSSWWIINPDGGKSGKAP--RRRAVSMDNSN-KYTKSRGRAAKKKAALQA----- --------APESADDSPSQLSKWPGSPTSRSSDELDAWTDFRSRTNSNASTVSGRLSPIL ASTELDDVQDDD-GPLSPMLYSSS-ASLSPSVSKPCTVE-----LPRLTDMAGTMNLNDG LAENLMDDLLDNIALPPSQPSPPGGLMQRGSSFPYTAKSSGLGSPTGSFNSTVFGPSSLN SLRQSPMQTIQENRPATFSSVSHYGNQTLQDLLASDSLSHSDVMMTQSDP--LMSQASTA VSAQNARRNVMLRNDPMMSFAAQPTQGSLVNQNLLHHQHQTQGALGGSRALSNSVSNMGL SDSSSLGSAKHQQQSPASQSMQTLSDSLSGSSLYSASANLPVMGHDKFPSDLDLDMFNGS LECDMESIIRSELMDADGLDFNFDSLISTQNVVGLNVGNFTGAKQASSQSWVPG FOXO4 >H sapiens MDPGNENSATEAAAIIDLDPDFEPQSRPRS--------CTWPLPRPE-IANQPSEP---- --PEVEPDLGEK--------VHTEGRSEP-----------------------------IL LPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGN----QSYAELISQAIESAPEKRLTL AQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHN--EATGKSSWWMLNP EGGKSGKAP--RRRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPVGHFAKW-S GSPCSRNREEADMWTTFRPRSSSNASSVSTRLSPL---RPESEVLAEE-IPASVSSYAGG VPPTLNEGLELLDGLNLTSSHSLLS-RSGLSGFSLQHPGVTGPLHTYSSSLFSPAEGPLS AGEGCFSSSQALEALLTSDTPPPPADVLMTQVDPI------LSQAPTLLLLGGLPSSSKL ATGVGLCPKPLEAPG-----------PSSLVP--TLSMIAPPPVMASAPIPKALGTPVLT PPTEAASQDR-MPQDLDLDMYMENLECDMDNIISDLMDE------GEGLDFNFEPDP--- ---------------------------- >H glaber MDPGNKNSATEAAAIVDLDPDFEPHSRPRS--------CTWPLPRPE-LATEPSEP---- --PEVEPGLGQK--------VHPEGRSEP-----------------------------IL LPSQLPEPAGGPQPGILGAVTGPRKGGSRRNAWGN----QSYAELISQAIESAPEKRLTL SQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHN--EATGKSSWWMLNP EGGKSGKAP--RRRAASMDSSSKLLRGRSKAPKKKPSVLPAPPEGATPTSPISHFAKW-S GSPCSRSREEADMWTTFRPRSSSNASTVSTRLSPM---RPESEVLAEEEMPASVSSYAGG VP-TLNEDLELLDGLNLTSPHSLLS-RSSLSGFSLQHAGVTGPLHTYSTSLFSPAEGPLS PE-GCFSSSQSLEALLTSDKPPPPADVLMTQVDPI------LSQAPTLLLLGGIPSSSKL STGVGLCPKPLEAPG-----------PSSLVP--SLPIMVPPPVMAGAPIPKALGAPVLT PSTEAAGQDR-MPQDLDLDMYMENLECDMDNIISDLMDG------GEGLDFNFEPDP--- ---------------------------- >M brandtii MDPENENSATEAAAIIDLDPDFEPQSRPRS--------CTWPLPRPE-LATQPSKP---- --PEVDPGLGEK--------VHTEGRTEP-----------------------------IL LPSRLPEPAGGPQSGILGAVTGPRKGGSRRNAWGN----QSYAELISQAIESAPEKRLTL AQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHN--EATGKSSWWMLNP EGGKSGKAP--RRRAASMDSSSKLLRGRSKAPKKKPVVLPAPPEGATPKSPVGHFAKW-S GSPCSRNREEADVWTTFRPRSSSNASTVSTRLSPL---RPESEVLAGEEMPASVSSYAGG VPPTLKEDLELLDGLNITSSHSLLS-RSSLSGFSLQHPGVTGPLHTYSTSLFSPAEGPLS AGEGCFSSSQSLEALLTSDTPPPPANVLMTQVDPI------LSQAPTLLLLGGIPSSSKV ATGVGLCPKPPEAPG-----------PSSLIA--PLPMIAPPPVMVGAPIPKTLGTPMLT PSTEATSQAR-MPQDLDLDMYLENLECDMDNIISDLMDG------EEGLDFNFEPGFVIV TCCKHYRHYWGKHGEGVHQQESSSGKQY >S franciscanus --------------WARPN----KTLRDRV--------CRGQRKWEEVCQPYPRRG---- --PRIRFCHHKLLIILTPHSVPPSSTEET-----------------------------RD TKPILPLEGGENRE--LSTPSSQR-NGPRRNAWGN----LS-ADLITKAIQSAPDQRLTL SQIYDWMVKNVPIFKDKGDSNKT--------RPTCLATDWSK-----EGIG---FWLFQK HCSCTSIKPFCCKPGWKITLVGSRFTSDMRRSRARPWLLSMPWTRPATLSLDALTSSWRT TNPSSRPLVTAP--TTSRTLAFATKRSRFGTASGLFTFQASAMLLP---MPSPVIPLV-- ---SLNSFLSLMMSRTFGTPSTPFHIHPCIIDSLLLSAPLLTTFRRCAQQM--PHHQPKS SG----LSLRMTSVWPQQATPPCPGCPSSRRASPTNATPSRQTSASTTSFESTSLASMVL CIVIAWSSRPPFEAACCRPYTLHTRASRKCAPEQNLPSFGQAPQLSSRCGPDALPATACR PLS--------LPHPHPTGL--------------------------PGLPIPVHCCLLSF ---------------------------- >S purpuratus --------------MVDNDPDFEPQARPRS--------CTWPLRRPDFLDSKPGQPGNAA GAPPVDHAHSAL--------SPAVLAEEP-----------------------------LD IKPVLPLEGGENRE--LSTPSSQRRNGSRRNAWGN----LSYADLITKAIQSAPDQRLTL SQIYDWMVKNVPFFKDKGDSNSSAGWKNSIRHNLSLHSRFVRVQN--EGTGKSSWWMINP D-AKPGKSS--RRRASSMDTTNSKFERKRGRVKKKVLEERAKWGNTSPTPKLE--GEE-G ASPLPFNLATTD----FRSRASSNASSCG-RLSPIMTTHPEIDMHDNEVPPMSPIPFQ-D LPPS--QAYDSPDPYQSTDQLAKLA-KAMTLDSSLSVEPAIRHTHNNGGYLFSP------ ------------QSYSGSDMSPVHSN------SPY------YSQQ-------GTPAVSPL GQCSPMQELPPSQYGMQRSFTNLIHENESIIP--QDPMFAQSAVLRQQQSPRPMPSCREE SMNQHTSPHRLMPSSMNQGSNLAMLLNNGHNTHTTSHHHHPQPYPNGGTPHXVHPQC--- ---------------------------- >L variegatus -----------------------NTFKMIY--------C-----RDEYISCIIRSTINLQ IEDQFSFLLYKC----------AQLCCSQ-----------------------------ID LHVLVRLSSS------QCTISILKRNTDLNT-YTC----FIFY-LLLHLICCAKFLHNYL SKI------------SISSSSLAFSMQNSIRHNLSLHSRFVRVQN--EGTGKSS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >M musculus MDPENKKSATGAAAILDLDPDFEPQSRPRS--------CTWPLPRPD-LATEPHEP---- --SEVEPSLGQK--------VPTEGHSEP-----------------------------IL LPSRLPEPAGGPQPGILGAVTGPRKGGSRRNAWGN----QSYAELISQAIESAPEKRLTL AQIYEWMVRTVPYFKDKGDSNSSAGWKNSIRHNLSLHSKFIKVHN--EATGKSSWWMLNP DGGKGGKAP--RRRAASMDSSSKLLRGRSKGPKKKPSVLPAPPEGATPRSPLGHFAKW-S SSPCPRNREEADVWTTFRPRSSSNASTVSTRLSPM---RPESEVLAEEEMPASASSYAGG VPPTLSEDLELLDGLNLASPHSLLS-RSGLSGFSLQHPGLAGPLHSYGASLFGPIDGSLS AGEGCFSSSQSLEALLTSDTPPPPADVLMTQVDPI------LSQAPTLLLLGGMPSSSKL GTGVSLCPTPLEGPG-----------PSNLVP--NLSVMAPPPVMAGAPIPKVLGTPVLA SPTEDSSHDR-MPQDLDLDMYMENLECDMDNIISDLMDG-------EGLDFNFEPDP--- GPx >H sapiens ----------------------------------------------------MARLLQAS CLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVN VASYXGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGF VPNFQLFEKG-DVNGEKEQKFYTFLK---NSCPPTSELLGTSDRLFWEPMKVHDIRWNFE KFLVGPDGIPIMRWHHRTTVSNVKMDILSYMR---RQAALGVKRK------ >H glaber MLLAPEIPASLRLAGGPCLAMDWPSLRPEKWLQGSDAQTDGQPGCQTVLNAAMARLLRAS CLLSLLLAGSVPWSLGQEKSKTECHGGVSGTIYEYGALTIDGEEYIPFKKYSGKYILFVN VASYXGLTDQYLELNALQEELEPFGLVVLGFPCNQFGKQEPGENSEILPSLKYVRPGRGF VPNFQLFEKG-DVNGEKEQKFYTFLK---NSCPPTAELLGSPSRLFWEPMKIHDIRWNFE KFLVGPDGKPVMRWYHRTTVGSVKVDILAHMR---RQAALLAPGK------ >M brandtii ------------------------------------------------------------ ---------------------MDCYKDVKGTIYEYDALTLDGKEHISFKQYVGKHVLFVN VATYCGLTAQYPELNTLQEELKPFGLVVLGFPCNQFGKQEPGENLEILPGLKYVRPGGGY VPNFQLFEKG-DVNGEKEQKVFTFLK---HSCPHPSELLGSFKHISWEPIKVQDIRWNFE KFLVGPDGVPVMRWFHRAPVSAVKSDILLYLK--------QFKTK------ >S franciscanus ----------------------------------------------------FKMATYKQ IVFAFFALAVCSRLSEATTLDAVCYDDAK-SLSD-----VAITERLSLDGYRGKVVLVVN TASFCTYTHQYPYFNKLQNHFGD-QLVILGFPCNQFSLQEPGMGQEIPNTLRYVRPGGGY KPNFYLNKEKIDVNGPKAHPLFQKMK---NSCPPVKIEIGDPSDLYWSPMTIGDITWNFN KFLLDKEGVPFKRYDSAVEPLQLVHDIQLILDGAYKMVKRPSRPKYAREAL >S purpuratus --------------------------------------------MRGCSFSFFKMATYEK IILAFFALVVCSRLSGATMLDAVCYDDAE-SLSD-----VAMTKSLSLDDYRGKVVLVVN TASFCTYTYQYPYFNELKNEFGD-QLAILGFPCNQFWLQEPGVGQEIPNTLRYVRPGGGY EPNFYLNEEKIDVNGPKAHPLFKKLK---NSCPPVKMEIGDPSNLYWSPMTIGDVTWNFN KFLLDKEGVPFKRYDSVVEPLQLVSDIQLVVDGDYKTVKRPSRPKYATEEL >L variegatus ---------------------------------------------NINPVDIFKMALNDE VILIVLALALFPYVSKATMIDSVCYDDAE-SLHE-----VEITESLSLGDYRGKVVLVVN TASFCTYTHQYPLFNKLQDQFDD-ELAILGFPCNQFGLQEPGLGEEIPNTLRYVRPGGGY QPNFYLNEKKIDVNGPNAHPLFTKLKVYIHKKTPIIFYIGP--DWPYQERGGGRAIW--K QTLTNNGGDEGRRKTGRRKIKSIRLNLFHINIKRFQICIMITRGKCIEPT- >M musculus ----------------------------------------------------MARILRAS CLLSLLLAGFVPPGRGQEKSKTDCHGGMSGTIYEYGALTIDGEEYIPFKQYAGKYILFVN VASYXGLTDQYLELNALQEELGPFGLVILGFPSNQFGKQEPGENSEILPSLKYVRPGGGF VPNFQLFEKG-DVNGEKEQKFYTFLK---NSCPPTAELLGSPGRLFWEPMKIHDIRWNFE KFLVGPDGIPVMRWYHRTTVSNVKMDILSYMR---RQAALSARGK------ IGF1R >H sapiens ------------------------------------------------------------ --------------------------------MKSGSGGGS---PTSLWG---LLFLS-- ------AALSLWP----------------------TSGEICGPGIDIRNDYQQLK----- -----RLENCTVIEGYLHILLI--SKAEDYRSYR--------------FPKLTVITEYLL LFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKN ADLCYLSTVDWSLI-LDAVSNNYIV-----GNKPP-KECGDLCPGTMEEKPMCEKTTINN -----EYNYRCWTTNRCQKMC------PSTCGKRACTENNECCHPECLGSCSAPDNDTAC VACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSD-SEG---FVIHDGECM QECPSGFIRNGSQSMYCIPCEGPCPKVC-EEEKKTKTIDSVTSAQMLQGCTIFKGNLLIN IRRG--NNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEE--QLEGNYS FYVLDNQNLQQLWDW-DHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDIN TRNNGERASCESDVLHFTSTTTSKNR--IIITWH--RYR-PPDYRDLISFTVYYKEAP-- FKNVTEYDGQDACGSNSWNMVDVDLP-----PNKDVEPGILLHG-LKPWTQYAVYVKAVT LTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYI VRWQRQPQDGYLYRH-----NY-----------------CSKD-KIPIRKYADGTIDIEE VTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFV--PRPERKRR DVMQVANTTMS----------------------------SRSRNTTAADTYNITDPEELE TEYPFF------------------ESRVDNKERTVISNLRP-----FTLYRIDIHSCNHE AE-KLGCSASNFVFARTMPA--EGADDIPGPVTWEPRPENS--IFLKWPEPENPNGLILM YEIKYG------SQVEDQR-----------------------------ECVSRQEY-RKY GGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALP------- ---VAVLL----IVGGLVIM----LYVFHRKRNNSRLGNGVLYASVNPEYFSAAD----- VYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPE--TRVAIKTVNEAASMRE RIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEME-NNP VL---APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRD IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNE QVLRFVMEG-GLLDKPDNCPDMLFELMRMCWQYNP-KMRPSFLEIISSIKE--------- ------------------------------------------------------------ ---------------------------E--MEPGFREV-----------------SFYYS EENK-----LP----EPEELDL----------EPENMESVPLDPS--------------- ---------------------------------------ASSSSLPLPDRHSGHKA---- ------ENGPGPGVLV-------------------------------------------- ----------------LRASFDERQPYAHMNGGRKNERALPLP-------------QSST C-------------------------------------------- >H glaber ------------------------------------------------------------ --------------------------------MKSGSGGGP---PTSLWG---LLFLS-- ------AALSLWP----------------------TSGEICGPGIDIRNDYQQLK----- -----RLENCTVIEGYLHILLI--SKAEDYRSYR--------------FPKLTVITEYLL LFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKN ADLCYLSTVDWSLI-LDAVSNNYIV-----GNKPP-KECGDLCPGTMEEKPLCEKTTINN -----EYNYRCWTTNRCQKMC------PSACGKRACTESNECCHPECLGSCRAPDDDTAC VACRHFYYAGVCVPVCPPGTYRFEGWRCVDRDFCANIPNAESSDSSEG---FVIHDGECM QECPSGFIRNGSQSMYCIPCEGPCPKVC-EEEKKTKTIDSVTSAQMLQGCTIFKGNLLIN IRRG--NNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEE--QLEGNYS FYVLDNQNLQQLWDW-DHRNLTIKSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDIN TRNNGERASCESDVLHFTSTTTWKNR--IIITWR--RYR-PPDYRDLISFTVYYKEAP-- FKNVTEYDGQDACGSNSWNMVDVDLP-----PNKDVEPGILLHG-LKPWTQYAVYVKAVT LTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYI VRWQRQPQDGYLYRH-----NY-----------------CSKD-KIPIRKYADGTIDVEE VTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFV--PRPERKRR DVMQVANTTMS----------------------------SRSRNTTVADTYNVTDPEELE TEYPFF------------------ESRVDNKERTVISNLRP-----FTLYRIDIHSCNHE AE-KLGCSASNFVFARTMPA--EGADDIPGPVTWESRPENS--IFLKWPEPENPNGLILM YEIKYG------SQTEDQR-----------------------------ECVSRQEY-RKY GGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFIHLIIALP------- ---VAILL----IVGGLVIM----LYVFHRKRNNSRLGNGVLYASVNPEYFSAAD----- VYVPDEWEVAREKIAMSRELGQGSFGMVYEGVAKGVVKDEPE--TRVAIKTVNEAASMRE RIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEME-NNP VL---APPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRD IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNE QVLRFVMEG-GLLDKPDNCPDMLFELMRMCWQYNP-KMRPSFLEIISSIKD--------- ------------------------------------------------------------ ---------------------------E--MEPGFREV-----------------SFYYS EENK-----PP----EPEELDL----------EPENMESVPLDPS--------------- ---------------------------------------ASSSSLPLPDRHSGHKA---- ------ENGPGPGVLV-------------------------------------------- ----------------LRTSFDERQPYAHMNGGRTNERALPLP-------------QSST C-------------------------------------------- >M brandtii ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MDIRNNFTRLY----- -----ELANCSIIEGHLQILLMFSSRPEDFRDLS--------------FPKLIMITDYLL LFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSVRIEKN NDLCYLATIDWSRI-LDSVEDNYIV-----LNKDDNEECGDVCPGTAKGKTSCPATVING -----QFVERCWTHSHCQKVC------PTSCKSHGCTAEGLCCHPECLGSCSEPDDPTKC VACRHFYLDGRCVETCPAPYYHFRDWRCVNFSFCLDLHNKCKNSRRQGCHQYVIHNNKCI PECPSGYTMNSSNLM-CTPCLGPCPKVC-HVLEGQKIIDSVTAAQELRGCTVINGSLTIN IRGG--NNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIQGDT--LEVGNYS FYALDNQNLRQLWDWSKH-NLTITRGKLFFHYNPKLCLSEIHKMEEISGTKGRQERTDIA LKTNGDQASCENELLKFSYIRTSSDK--IMLKWE--PYW-PPDFRDLLGFMLFYKEAP-- YRNVTEFDGQDACGSNSWTVVDIDPPPRSTDPKSQAHPGWLMRS-LKPWTQYAIFVKTL- VTFSDERRTYGAKSDIIYIQTNATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYL VFWERQEEDSELYEL-----DY-----------------CLKGLKLPSRTWSPPS-ELEG SQKHNQSE-YDEAAGECCSCPKTDSQILKELEESSFRKTFENYLHNVVFV--PRSSRKRR ALGDEGNVT-T----------------------------AEPTALGFPNTSTIV-PTRSE EPRPF--------------------EKVVNKESLVISGLRH-----FTGYRIELQACNQD FP-EERCSVAAYISARTMPE--AKADDIVGPVTHEIFENNI--VHLMWQEPKHPNGLIVL YEVSY-------RRYGDEE---------------------------LHLCVSRRHF-ALE RGCRLRGLSPGNYSVRVRATSLAGNGSWTEATYFYVTNYLDVPSNIAKIIIGP------- ------LI--FVFLFSVVIG---SIYLFLRKRQSDG-PVGPLYASSNPEYLSASDVFPCS VYVPDEWEVPREKITLLRELGQGSFGMVYEGNAKDIIKGEAE--TRVAVKTVNESASMRE RIEFLNEASVMKGFACHHVVRLLGVVSKGQPTLVVMELMTHGDLKSHLRSLRPDAE-NNP ---GRPPPTLQEMFQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRD IYETDYYRKGGKGLLPVRWMAPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNE QVLKFVMDG-GYLDIPDNCPERLSELMSMCWHFNP-KMRPTFLEVVDLLKD--------- ------------------------------------------------------------ ---------------------------N--LHPSFPEV-----------------SFFYS EENK-----AP----ENDELEM----------EFEDMESVPLDRS--------------- -------------------------------------------------SHCQRE----- ------EDGGCPLA---------------------------------------------- ----------------LKRNYEDHMSYSHMNGGKKNGRVLTLP-------------RSSP S-------------------------------------------- >S franciscanus ------------------------------------------------------------ ---------------------------------------NE-------------LFV--- FIYLF---------------------------------TVC-QSMDIRNSAEKFS----- -----KLENCTVIEGYLQIVLIDHATPSDYAGLS--------------FPKLREITEYFV MFRVKNLQTLRHIFPNLAVIRGDSLFFNYALIIFEMFELQEIGLPSLQAVMRGSVRIEKN INLCYLSTVDWSLVQFQGMENNFIK-----GNKDQ-EECFNFCPED-DGKRLCRKLTASG -----DVAELCWTNEHCQKGK------PVSC-PRSCNAAGRCCHEQCIGGCSGS-TPSDC TACRHFLHLGVCVGECPNGTFQVSQ----SFQSC-----------SKK---LFLGQIRIL IKFLARIILPSRQCKLILSLSLFLLLVC-----DGKTIQSVEDAADMRGCTYVHGSLTIS VHGR--GTVA-----------------------PWIGCKIYRSYEE-QGKK--------- ---------------------YTGTGGEFAAEMPKRSPQNLDRVQ--CKTNQRLSMMCLF LAS---HSVGNTHRLNLEF-NFFGTF--LMVNWS--PPKGKGDVREIVGYILSYREAP-- QRNVTELDGEDACGTSLWEVQYI--P-----PT---DTSTFVSN-LKPWTQYAFMVRTYT IAGAQ----FSARYMIIYSLYPEAEASPPSSLKVISNSSSELIITWKPPEHPNGNLTHYI ISWEPQ----YLPIHQFEDRDF-----------------CRES-CIPRTIIISSLIHIIA P--------YYGQS--SCISDTQCIRLT----------------HNSLIM---------- NKTFLVHYP-------------------------------AHYDLTTTSFIQPI-PITPE SEHNLNGSLYPSSPATGVNASTTPPSRVEERVIGLVESFRVTGLEHFTEYFITLQACN-- ---SKDCSRAAAMYGRSLPK--ESADQIESAVMINHTSTDR--VHLTWAEPSNPNGIIVI HEIRFEMMDVEVNDVGDERDAYTVVESRSTPKPVT-------QSTENTECVSAEGY-RRV LGAELLGLKVGNYTAMVRAVSLAGEGPWTKPVMFSVPDITNSSYAKAALILCA-----KP VRSCYLLKKPIAEILSYI-----HYPRHIKQS-HSHMKQ----ISISKYYIMIIY----- VYVADEWEFPRDKLEIIRELGKGSFGMVYEGLAKGILPEEEEI-SRVAIKSVQANASMRD RIEFLNEASYMKLIDAHNVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQQDLP -VELKNVYSVRALIGMIAQIASGMAYLSSMNFVHRDLAARNVLVGEGNVCKVADFGLARD IYQSDYYRKESGGKLPIRWMAPEALLYGIFTIKSDVWSFGILLWEIVTYGKIPYPGLDNE EVIEYIRQG-YRLPPPEGCPEEMYALMTKCWSYIP-AKRPPFKDISTRLKA--------- ------------------------------------------------------------ ---------------------------Y----PILKEV---------------ALCILLN KLSG-----PIPQYGAASPMFL----ECSCRQSITQVISCPAHPQICR------------ -----------------------------------------PLASKASLIYHQI------ ------TIKPCRDHTI-------------------------------------------- ------------------TSYQSQILF-HPSMTMQQDQLCYLP-------------SIYI P-------------------------------------------- >S purpuratus ------------------------------------------------------------ --------------------------------MMDGLARPARMGRTSVRSTTLLFFIIFI VCSLFCISNVAG-------A---------------DADGVC-KSMDIRNSAEKFA----- -----KLENCTVIEGYLQIVLIDHATPSDYAGLS--------------FPKLREITEYFV MFRVKNLQTLRHIFPNLAVIRGDSLFFNYALIIFEMFELQEIGLPSLQAVMRGSVRIEKN INLCYLSTVDWSLVQFQGMENNFIK-----GNKDQ-EECFNFCPED-DGKRLCRKLTSSG -----DVAELCWTNEHCQKVC------PASC-PRSCNAAGRCCHEQCIGGCSGS-TASDC TACRHFLHLGVCVGQCPNGTFQFKNRHCITGERC-----------PSG---WRLFNEKCT EECPGGYMPDFNDSRHCLPCTGTCPKVC-----KGKTIQSVEDAADMRGCTYVHGTLTIS VHGR--GNVLKELERNLGMIEVISDALIVRRANSLVSLNFLRNLRKIEGRDGGLEMDQYS LYVLANNNLQQLFDFSQHPNITIVNGKFFFHYNPKLCYSEIEELHNLTGIKEPLSNVDVS LSSNGDQVACNTHRLNLQF-NFFGTF--LMVNWS--PPKGKGDVREIVGYILSYREAP-- QRNVTELDGEDACGTSLWEVQYI--P-----PT---ETSTFVSN-LKPWTQYAFMVRTYT IAGAQ----FSARSNIEYRLTPEAKASPPSSLKVISNSSSELIVTWKPPEHPNGNLTHYI ITWEPQ----YLPIHQFDDRDF-----------------CREK--LPNLRKSESSTEMET SEDEDTNTTMVGAG--CCMCPIDPDELARREEDARFQKDFENQLHNTIYK--RRPDTRRR KKRDVPGSAIQ----------------------------DAGTTPTTTSFITPI-PTTPT SGFNLNGSLYPSSPATGVNASTTSPSRVEERVIGLVESFHVTGLEHFTEYFITLQACN-- ---SKDCSRAAAMYGRSLPK--ESADQIESAVMINHTSTDR--VHLTWAEPSNPNGIIVI HEIRFEMMDVEVDDVGDERDAYTVVESHSTPKPVT-------QSTENTECVSAEGY-KRV LGAELLGLKVGNYTAMVRAVSLAGEGPWTKPVMFSVPDITNNPTYEPDKALPP---MMGV TIAVSIAAVII--IIVFIIIF---LRWHYRK---DQMPDGVLYASVNPEYMSTSD----- MYVADEWEFPRDKLEIIRELGKGSFGMVYEGLAKGILPEEEEI-SRVAIKSVQANASMRD RIEFLNEASVMKLIDAHNVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQQDLP LIDRKSVPTLEQLLNMAAEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLARD IYQSDYYRKERGGMLPIRWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNE EAGEYIKGG-NVLRPPENCPEKMQEIMMACWQYQE-KLRPLFGEIILNLQD--------- ------------------------------------------------------------ ---------------------------YGLLRDSFAQN-----------------CFFLN EQLN-----A-----SAAPADM----------SSKELETVSILDQ--------------- ------------------------------------------NAKNNENLYTSMSNNK-- -------PEGASNGG--------------------------------------------- ----------------NRAGGSVEVPIVTGPSSSPKDRNGSLTG------------NGSI PHGVGVG-KCTEC-------------------------------- >L variegatus ------------------------------------------------------------ --------------------------------REDNLSINSLKLEVMLRG---FLFILNL VLKLL-INIILFT----------------------LFVTVC-KSMDIRNSAEYFS----- -----KLENCTVIEGYLQIVLIDHAKPSDYAGLS--------------FPKLREITEYFV MFRVKNLQTLRHIFPNLAVIRGDSLFFNYALIIFEMFELQEIGLPSLQAVMRGWVRIEKN INLCYLSTVDWSLVQVQGMENNFIK-----GNKDQ-EECFNFCPED-DGKRLCRKLTATG -----DVAELCWTGQDCQKVC------PVSC-PRSCNEAGRCCHEQCIGGCRGS-TASDC TACRHFLHLGVCVGQCPNRTFQVKNRHCITAEQC-----------PAG---WKLFNEKCT QDCPGGYMPDFNDSRHCLPCTGTCPKVC-----DGKTIQSVEDAAAMKGCTYVHGSLTIS VHGR--GTVVKELEQNLGMIEVVSDALIVRRANSLVSLNFLRNLRRIEGRVGGLEMSEYS LYVLANNNLQQLFDFSQHPNISIGNGKFFFHYNPKLCYSEIEKLHNLTGIKAPLSNIDVS LSSNGDQFAGNTHRLNLEF-AFFQSV--LSVRWS--PPKGKGDVREIVGYILSYREAP-- QRNVTELDGEDACGTSLWEVQYI--P-----PT---ETSTFVAN-LKPWTQYAFMVRTYT IAGAQ----FSARSNIQYLLTPESEASPPSSLNVISNSSSELVITWKPPEHPNGNLTHYI ITWEPR----YLFKQQFEDRDF-----------------CRQE--LPTLRKSESSTEMET SEDEDTNTTMVGAG--CCTCPIDPEELRRREEDARFQKDFENQLHNNIYMAYATSSATRS GASQYIHYAID----------------------------DIEVSKLQYELHTPL-SKQYK SCYFIYGMILCYIRYAL-------PALIDQHIHSFISRY-------IAHYYRDSQRHHLP YR-SWSASKIISICPMPIARIYESADQIESTVMINHTSTDR--VHLTWAAPTNPNGIVVI HEVRFEMVDPKVDDVGDERDAYTVVESLSTPKPVT-------QSTENTECVSAEGY-RRV LGAELLGLKVGNYTAMVRAVSLAGEGPWTKPVTFSVPDITNSCYIIAAAVAKSQFPSLSI VQYCHIMH--YSYIYSII------CYIIYRK---DQMPDGVLYASVNPEYIIISP----- VYVADEWEFPHDKLEIIKKLGKGSFGMVYEGLAKGILPDEEDI-SRVAIKSVQANASMRD RIEFLNEASYSK-IEAHHVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQQDLP LIDRKNVPSLRQLIYMAAQIADGMAYLSSQRFVHRDLAARNILVGENYTCKIADFGLARD IYQSDYYRKEGGAKFPIRWMAPESLLYGKFTIKSDVWSFGVLLWEIVTLGRIPYPGLSNA EVPKYIKGG-NSLRPPENCSPQM-AILFQSWYYEKICLRSSALKNLARQGA--------- ------------------------------------------------------------ ---------------------------R----CIYAKE---------------KICFSKP EIYH-----KI----HCSDFYK----------LPLDLELIPYICM--------------- --------------------------------------------SVLILIHCLQY----- ------DKTLCQKVSL-------------------------------------------- ----------------FQSASACCLQGVWCVVGDHSKRSIAVP-------------SELK CRGPQVR-GIWTC-------------------------------- >M musculus ------------------------------------------------------------ --------------------------------MKSGSGGGS---PTSLWG---LVFLS-- ------AALSLWP----------------------TSGEICGPGIDIRNDYQQLK----- -----RLENCTVIEGFLHILLI--SKAEDYRSYR--------------FPKLTVITEYLL LFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKN ADLCYLSTIDWSLI-LDAVSNNYIV-----GNKPP-KECGDLCPGTLEEKPMCEKTTINN -----EYNYRCWTTNRCQKMC------PSVCGKRACTENNECCHPECLGSCHTPDDNTTC VACRHYYYKGVCVPACPPGTYRFEGWRCVDRDFCANIPNAESSD-SDG---FVIHDDECM QECPSGFIRNSTQSMYCIPCEGPCPKVCGDEEKKTKTIDSVTSAQMLQGCTILKGNLLIN IRRG--NNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEE--QLEGNYS FYVLDNQNLQQLWDW-NHRNLTVRSGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDIN TRNNGERASCESDVLRFTSTTTWKNR--IIITWH--RYR-PPDYRDLISFTVYYKEAP-- FKNVTEYDGQDACGSNSWNMVDVDLP-----PNKEGEPGILLHG-LKPWTQYAVYVKAVT LTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPTLPNGNLSYYI VRWQRQPQDGYLYRH-----NY-----------------CSKD-KIPIRKYADGTIDVEE VTENPKTEVCGGDKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFV--PRPERRRR DVMQVANTTMS----------------------------SRSRNTTVADTYNITDPEEFE TEYPFF------------------ESRVDNKERTVISNLRP-----FTLYRIDIHSCNHE AE-KLGCSASNFVFARTMPA--EGADDIPGPVTWEPRPENS--IFLKWPEPENPNGLILM YEIKYG------SQVEDQR-----------------------------ECVSRQEY-RKY GGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTTYENFMHLIIALP------- ---VAILL----IVGGLVIM----LYVFHRKRNNSRLGNGVLYASVNPEYFSAAD----- VYVPDEWEVAREKITMNRELGQGSFGMVYEGVAKGVVKDEPE--TRVAIKTVNEAASMRE RIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEVEQNNL VL---IPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRD IYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNE QVLRFVMEG-GLLDKPDNCPDMLFELMRMCWQYNP-KMRPSFLEIIGSIKD--------- ------------------------------------------------------------ ---------------------------E--MEPSFQEV-----------------SFYYS EENK-----PP----EPEELEM----------EPENMESVPLDPS--------------- ---------------------------------------ASSASLPLPERHSGHKA---- ------ENGPGPGVLV-------------------------------------------- ----------------LRASFDERQPYAHMNGGRANERALPLP-------------QSST C-------------------------------------------- >C elegans MTRMNIVRCRRRHKILENLEEENLGPSCSSTTSTTAATEALGTTTEDMRLKQQRSSSRAT EHDIVDGNHHDDEHITMRRLRLVKNSRTRRRTTPDSSMDCYEENPPSQKTSINYSWISKK SSMTSLMLLLLFAFVQPCAS---------IVEKRCGPIDIRNRPWDIKPQWSKLGDPNEK DLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLL VFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDL-EIGLDKLSVIRNGGVRIIDN RKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKN QEQGVERVQSCWSNTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERVNDATAC HACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSN----KTVPIKATAGLCS DKCPDGYQINPDDHRECRKCVGKCEIVCEIN----HVIDTFPKAQAIRLCNIIDGNLTIE IRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRIEAKS--LFRNLYA ITVFENPNLKKLFDSTTD--LTLDRGTVSIANNKMLCFKYIKQLMSKLNIP--LDPIDQS EGTNGEKAICEDMAINVSITAVNADS--VFFSWPSFNIT-DIDQRKFLGYELFFKEVPRI DENMTIEEDRSACVDSWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVAT-- -QMVLHAGAKNGVSKIGFVRTSYYTPDPP-TLALAQVDSDAIHITWEAPLQPNGDLTHYT IMWR-ENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLLTMM GHEDQQKTCAATPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRDTMR VRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHISKKKPSSSSTTSTPAPTIASMYA LTRKPTTVPGTRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHYTLYAISLSACQNM TVPGASCSISHRAGALKRTKHITDIDKVLNETIEWRFMNNSQQVNVTWDPPTEVNGGIFG YVVKLK------SKVDG-------------------------SIVMTRCVGAKRGYSTRN QGVLFQNLADGRYFVSVTATSVHGAG--PEAESSDPIVVMTPGFFTVEIILG-------- ---MLLVFLILMSIAGCIIYYY------IQVRYGKKVKALSDFMQLNPEYCVDNK----- -YNADDWELRQDDVVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTE NLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVFNET DCNFFDIIPRDKFHEWAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARD LFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSND EVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSP-RDRPTFLQLVHLLAAEASPEFRDL SFVLTDN----------------------------------------------------- -----------QMILDDSEALDLDDIDDTDMNDQVVEVAPDVEN----------VEVQSD SERRNTDSIPLKQFKTIPPINATTS------HSTISIDETPMKAKQ----------REGS LDEEYALMNHSGGPSDAEVRTYAGDGDYVERDVRENDVPTRRNTGASTSSYTGGGPYCLT NRGGSNERGAGFGEAVRLTDGVGSGHLNDDDYVEKEISSMDTRRSTGASSSSYGVPQTNW SGNRGATYYTSKAQQAATAAAAAAAALQQQQNGGRGDRLTQLPGTGHLQSTRGGQDGDYI ETEPKNYRNNGSPSRNGNSRDIFNGRSAFGENEHLIEDNEHHPLV INDY >H sapiens --------------------------MAALAAAAKKVWSARRLLVLLFTPLALLPVVFAL PPKEGRCLFVILLMAVYWCTEALPLSVTALLPIVLFPFMGILPSNKVCPQYFLDTNFLFL SGLIMASAIEEWNLHRRIALKILMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPI ANAILKSLFGQKEVRKDPSQESEE----------------------NTAAVRRNGLHTVP TEMQFLASTEAKDHPGETEVPLDLPADSRKEDEYRRNIWKGFLISIPYSASIGGTATLTG TAPNLILLGQLKSFF--PQCDVVNFGSWFIFAFPLMLLFLLAGWLWISFLYGGLSFRG-W RKNKSEIRTNAEDRARAVIREEYQNLGPIKFAEQAVFILFCMFAILLFTRDPKFIPGWAS LFNPG-----FLSDAVTGVAIVTILFFFPSQRPSLK-----WWFDFK--APNTETEP--L LTWKKAQETVPWNIILLLGGGFAMAKGCEES-GLSVW-IGGQLHPLENVPPALAVLLITV VIAFF-TEFASNTATIIIFLPVLAELAIRLRVHPL------------------------- ------------------------------------------------------------ ---------------YLMIPGTVGCSFAFMLPVSTPPNSIAFASGHLLVKDMVRTGLLMN LMGVLLLSLAMNTWAQTIF-QLGTFPDWADMYSVNVTALPPTLANDTFRTL >H_glaber -----------------------------MTTCWQGLWAYRSYLIVLLLPIILLPLPILI PTKEAYCAYAIILMALFWCTEALPLAVTAFFPLFLFPLMGIMEASEVSTEYLKDTNILFI GGLIVAIAVEHWNLHKRIALRALLIIGVRPALLILGFMMVTAFLSMWISNTATTAMMVPI AHAVLEELQ---NTRMDSQGGSD-----------------------NPTFELQD--PSPQ KEVTKLENGQITPA-------HSEPRAMKSKEEVR--FSKGMSLCVAYSASIGGIATLTG TTPNLVMQGQMQSIF-PENPNIINFASWFGFAFPTMVILLLLAWLWLQFLFLGFNFKKNF GIGDQGKEKK--QAALQVIKIQHKLLGPMNFAEKAVTVLFVILVVLWFTREPGFFPGWGN LAFANSKGESMPSDGTVAMFISVILFIVPSKIPGL-------TQDPE--NPGKLQAPPAL LTWKTVNEKMPWNIMLLLGAGFALAKGSEKS-GLSEW-VGDKLSPLQHMPPPATALIICL LIATF-TECISNVATTTLFLPILASMAQAICLHPL------------------------- ------------------------------------------------------------ ---------------YIMLPCTLASSLAFMLPVATPPNAIVFSFGGLKVTDMARAGFLLN IIGVLVIMLAINTWSFHIF-NMHTFPSWAQSNATQCFPSQPDHTTASP--- >M_brandtii -----------------------------MATCWQGLWAYRFYLFVYLLPIILLPLPLLI PTKQAYCAYAIILMALFWCVEALPLAVTALFPLILFPMMGIMDAAEVCIEYFNDTNILFI GGLLVAIAVEHWNLHKRIALRVLLIIGVRPALLMLGFMMVTAFLSMWISNTATTAMMVPI AQAVLEQLHKA-PEDKDVEKGSD-----------------------NPTFELQE--TSPQ KEVTTLDNGQVHPV----PPGPLEPKAQRTQEQLR--FSQGMSLCVCYSASIGGIATLTG TTPNLVLQGQINSIF-PDNGNVVNFASWFGFAFPAMIILLVFAWVWLQLLFLGFNFRKNF GMGEEARGQQ--QAAVRVIQTEHRRLGPMTFAEMAVTFLFVLLVLLWFTREPGFFPGWGT LAFSNSKGESLVSDGTVAIFISIIMFIVPSEIPGL-------TQNPE--KPGKLKAPPAL LNWKTVNEKMPWNIVFLLGGGFALAKGSEES-RLSAW-LGDKLTPLQSVSPPAIAFILSI LVATF-TECTSNVATTTLFLPILASMAKAICLHPLYVMLPCTLAASLAFMLPVATPPNAI VFSFGGIKVSDMESRLSAWLGDKLTPLQSVSPPAIAFILSILVATFTECTSNVATTTLFL PILASMAKAICLHPLYVMLPCTLAASLAFMLPVATPPNAIVFSFGGIKVSDMVRAGFLLN ILGVLVIMLAINTWSTPIF-SLNTFPPWAFANATHCMANATA---PGP--- >S franciscanus ---------------------------KQCLVVWVYSYQHLEFVQLNEHKNNYALICPKY SKKIGYMAFTIIIMATYWVTEVIPIAATALIPMVLLPLFGIQDSGDVIQQYLKSTTFLFF GGLVLAAAIEHQNLHRRFALRVLLLFGTKPKWLMFGFMSATAFLSMWMSNTATTAMMIPI AQAVLDELK---SQRIDEEMGGDVDKNDGNGSPLYKVT---TSSC-QGYIAICQFIGG-H QSIVEEPGSLPVEIKN---APLLIEEESPAERGYR-LLCKGITLSIPYAANIGGTATLTG TGPSIAISTQFCSLYGPEAG--LTFASWMMYAIPGMIICLLICWIWLQIIYIDF-PCLQR SDKRVGIAQE--ERAKMVIRRSYTALGKMSFAEWAILGHFVILISLWLTRDPKFVSGW-S VGFLT--G--YVTDATSVIFISVLLFSFPSRPPSFLCRRKQDDDGSEDKKPAKI---PAL LTWPVVHEKMAWSVIILLGGGSALADGCKVNYHVCAYHIAHRCAPQIYLQYGLIPYLKPK YMYYYYLLISYIVKSFTYFY-----CAVATRINPL------------------------- ------------------------------------------------------------ ---------------YLMLPATISASFAFMLPVATPPNAIAFASKELSVIDMVGSGVVMN IACILVSNLSLNTLGVWVF-DVKTFPDWANRKAR----------------- >S purpuratus -------------------------MGKERGLEFQEVLKNWQYLVIVLVPIIFGWVPIAF NNSIGHMAYCIIIMALYWMTECLPLAATALLPILLFPLFGIQKSSDVCSNYLTDTNTVFF GGLMVAAAVEHWNLHKRIALRVLMLVGAKPRWLMFGFMSTTAFLSMWMSNTATTAMMIPI SQAVLDELK---PSENDEETGGDVDKNDENGSPMHKGSEEKEEHCSENPIELDEIAAG-- -HIVEEPGSFPVEIKN---APLLIEEESKADRGHR-LLCKGITLSIPYAANIGGTATLTG TPPNLVISAQVKKLFGPEVG--VNFGTWMMYAFPGMVICLLICWVWLQIMYLDF-FCLQR SDKRVGLAQE--ERAKMVIRRSYAALGKISFAEWAILGHFVVLVILWLTRDPKFVNGW-S VNFLK--G--YVTDATSVIFISLLLFAFPSRLPSFFCRKKQDDDGSEDKKPAKI---PTL LTWPVIHEKMAWSVIILLGGGSALADGCKVS-GLSAW-LGGQFKEFSALSPAALAIIIST VVATF-TEVTSNTATATIFLPIFAELSISIGLNPL------------------------- ------------------------------------------------------------ ---------------YLMLPAVIACSFAFMLPVATPPNAIAFAHGNLTVLDMAKAGIVMN IACIIVSNLSLNTLGVWVF-DVKTFPAWANRTVT----------------- >D melanogaster MATETTKMIYTPPPLDIKMEIEIGEQPQPPVKCSNFFANHWKGLVVFLVPLLCLPVMLLN EGAEFRCMYLLLVMAIFWVTEALPLYVTSMIPIVAFPIMGIMSSDQTCRLYFKDTLVMFM GGIMVALAVEYCNLHKRLALRVIQIVGCSPRRLHFGLIMVTMFLSMWISNAACTAMMCPI IQAVLEELQ---AQ------GVC-----------------------KINHEPQYQIVGGN KKNNEDEPPYPT------------------------KITLCYYLGIAYASSLGGCGTIIG TATNLTFKGIYEARF-KNSTEQMDFPTFMFYSVPSMLVYTLLTFVFLQWHFMGLWRPKSK EAQEVQRGREGADVAKKVIDQRYKDLGPMSIHEIQVMILFIFMVVMYFTRKPGIFLGW-- ADLLNSKD---IRNSMPTIFVVVMCFMLPANYAFLRYCTRRGGPVPT--GPT-----PSL ITWKFIQTKVPWGLVFLLGGGFALAEGSKQS-GMAKL-IGNALIGLKVL-PNSVLLLVVI LVAVFLTAFSSNVAIANIIIPVLAEMSLAIEIHPL------------------------- ------------------------------------------------------------ ---------------YLILPAGLACSMAFHLPVSTPPNALVAGYANIRTKDMAIAGIGPT IITIITLFVFCQTWGLVVYPNLNSFPEWAQIYAAAALGNKTH--------- >L variegatus -------------------------EIRNMGFAFQEALRNWHYLVIVLVPIIFCPVPIVF NNSIGYMAYCIIIMALYWMTECIPLAATALLPILLFPLFGIQKSKDVCSNYLTDTNTVFF GGLMLAAAVEHWNLHKRIALRVLMLVGAKSRWLMLGFMSGTAFLSSWMSNTATTAMMIPI AQAVLNELK---SQKHDGEMGNDVGKVEENSNIITAFA-----YC-KSILLVDYFYVTLY IRIIKVLDSVPRCMST---KENLSTRENRSERRHR-RLCKAITLSIPYAAGIGGIASLTA TPANVVCVAQVERLFGSEAG--LNFGTWMMYAFPGMIVCLLICWIWLQIMYLDFLLINKI MINNIIQGDS--------VCYGHLELTHIVFAEWAILGHFVVLVALWLTRDPKFVSGW-S VGFLN--G--YVTDATSVIFISLLLFAFPSRLPTFLCRRNRGDDDPEDKKPAQI---PAL LTWPVVHEKMAWNVIILLGGGFALADGCKVS-GLSAW-LGAEFSVFSSLSPSAMAIIIST IVAIF-TEISSNTATATIFLPIFAELAVAMRINPL------------------------- ------------------------------------------------------------ ---------------YLMLTTTICASFAFMLPVATPPNAIAFAYKEIKVIDMVRAGIVMK IACILVSSLSINTLGVWIF-DVNTFPAWANVTAA----------------- >M musculus -----------------------------MATCWQALWAYRSYLIVLCLPIFLLPLPLIV QTKEAYCAYSIILMALLWCTEALPLAVTALFPIILFPLMGIMEASKVCLEYFKDTNILFV GGLMVAIAVEHWNLHKRIALGVLLIIGVRPALLLLGFMLVTAFLSMWISNTATTAMMLPI GYAVLEQLQ---GSQKDVEEGNS-----------------------NPSFELQE--ASPQ KEETKLDNGQAVSV-------SSEPRAQKTKEHHR--FSQGLSLCICYSASIGGIATLTG TTPNLVLQGQVNSIF-PENSNVVNFASWFGFAFPTMVILLLLAWLWLQVLFLGVNFRKNF GFGEGEEERK--QAAFQVIKTQHRLLGPMSFAEKAVTFLFVLLVVLWFTREPGFFPGWGD TAFANKKGQSMVSDGTVAIFISLIMFIIPSKIPGL-------TEDPK--KPGKLKAPPAI LTWKTVNDKMPWNILILLGGGFALAKGSEES-GLSKW-LGDKLTPLQHVPPSATVLILSL LVAIF-TECTSNVATTTLFLPILASMAQAICLHPL------------------------- ------------------------------------------------------------ ---------------YVMLPCTLAASLAFMLPVATPPNAIVFSFGGLKVSDMARAGFLLN IIGVLTITLSINSWSIPIF-KLDTFPTWAYSNTSQCLLNPPNSTVPGH--- >SIG ------------------------------------------------------------ +----------------------------------------------------------- ------------------------------------------------------------ ------------~--------+-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ INSR >H sapiens ------------------------------------------------------------ ------------------------------------------MATGGRRGAAAAPLLVAV AALLLGAAGHLY------------------PGEVCPGMDIRN-----------------N LTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS--------------FPKLIMITDYLL LFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKN NELCYLATIDWSRI-LDSVEDNYIV-LNKDDNEECGDICPG----TAKGKTNCPATVING -----QFVERCWTHSHCQKVC------PTICKSHGCTAEGLCCHSECLGNCSQPDDPTKC VACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCI PECPSGYTMNSSNL-LCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINI RGG--NNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGET--LEIGNYSF YALDNQNLRQLWDWSKH-NLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL KTNGDQASCENEL--LKFSYIRTSFDKILLRWEPYWPP---DFRDLLGFMLFYKEAPYQN VTEFDGQD-ACGSNSWTVVDIDPPLRSNDPKSQ--NHPGWLMRGLKPWTQYAIFVKTLVT FSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVF WERQAEDSELFE-LDYCLKGLKLPSRTWS---------------------PPFESEDSQK HNQSEYEDSAGECCSCPKTDSQILKELE------ESSFRKTFEDYLHNVVFV--PRKTSS GTGAEDPRPSRKRRSLGDVGNVTVAVPTVAA----------------FPNTSSTSVPTSP EEHR--------------------PFEKVVNK--ESLVISGLRHFTGYRIELQACNQDTP E-ERCSVAAYVSARTMPE--AKADDIVGPVTHEIFENN--VVHLMWQEPKEPNGLIVLYE VSYRRY-------GDE--------------------ELHLCVSRKH--FALERGCRLRGL SPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG---PLIFVFLFSVVIG SIYLF-------LRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLL RELGQGSFGMVYEGNARDIIKGEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENN-PG---RPPPTLQEMIQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDG-GYLDQPD NCPERVTDLMRMCWQFNP-KMRPTFLEIVNLLKDDLHPS------FPEV----------- --------SFFHSEEN---KAPESEELEMEFEDMENV--PLDRSSHCQREEAGGRDGGSS LGFKRS-----YEEH-------------IPYTHMNGGKKNGRILTLP------------- ------RSNPS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------- >H glaber ------------------------------------------------------------ ------------------------------------------MGAWGARGAATAPLLVAA AALLVGVTGHLY------------------PGEVCPGMDIRN-----------------N LTRLHRLENCSIIEGHLQILLMFKTKPEDFRDLS--------------FPKLVMITDYLL LFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSVRIEKN NELCYLATIDWSRI-LDSVEDNYIV-LNKDDNEECGDICPG----TTKGKTNCPATVING -----QFIERCWTHSHCQKVC------PTMCKSHGCTTEGLCCHSECLGNCSEPDDPTKC VACRNFYLDGRCVASCPPPYYHFQDWRCVNFSFCQELHNKCKNSRRQGCHQYVIHNDRCI PECPSGYTMNSSNL-MCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINI RGG--NNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGET--LEIGNYSF YALDNQNLRQLWDWSKH-NLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL KTNGDQASCENEL--LKFSSIRTSSDKILLRWEPYWPP---DFRDLLGFMLFYKEAPYQN VTEFDGQD-ACGSNSWTVVDIDPPLRSNDPKLQ--NHPGWLMRGLKPWTQYAIFVKTLVT FSDERRTYGAKSDILYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVY WQRQEEDSELYE-LDYCLKGLKLPSRAWS---------------------PPFESEDAQK HNQSEYEESAGECCSCPKTDSQILKELE------ESSFRKTFEDYLHNVVFV--PRNPSA GSGAQDPRPSRKRRSLGE-VNVTTAVPLVPG----------------FPTLSSVSVPTNA EEHR--------------------PFEKVVNK--ESLVISGLRHFTGYRIELQACNQDAP E-ERCSVAAYVSARTMPE--AKADDIVGPVTHEIFDNN--AVHLMWQEPKEPNGLIVLYE VSYRRY-------GEE--------------------ELHLCVSRKH--YALEKGCRLRGL QPGNYSVRIRATSLAGNGSWTEATYFYVTNYSDVSSNIAKMIIG---PLIFVFLFSIVIG SIYLF-------LRKRQPDGPMGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKITLL RELGQGSFGMVYEGNAKDIVKGEAE--TRVAVKTVNEAASLRERIEFLNEASVMKGFTCH HVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPESENN-PG---RPPPTLQEMIQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDG-GYLDQPD NCPERVTDLMRMCWQFNP-KMRPTFLEIVSLLKDDLHPS------FPEV----------- --------SFFHSEEN---KAPESEELEMEFEDMENV--PLDRSSHCQREEAGGREGGSS LGIKRN-----YEEH-------------IPYTHMNGGKKNGRILPLP------------- ------RSSPS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M brandtii ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------MDIRN-----------------N FTRLYELANCSIIEGHLQILLMFSSRPEDFRDLS--------------FPKLIMITDYLL LFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYSLMNITRGSVRIEKN NDLCYLATIDWSRI-LDSVEDNYIV-LNKDDNEECGDVCPG----TAKGKTSCPATVING -----QFVERCWTHSHCQKVC------PTSCKSHGCTAEGLCCHPECLGSCSEPDDPTKC VACRHFYLDGRCVETCPAPYYHFRDWRCVNFSFCLDLHNKCKNSRRQGCHQYVIHNNKCI PECPSGYTMNSSNL-MCTPCLGPCPKVCHVLEGQKIIDSVTAAQELRGCTVINGSLTINI RGG--NNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIQGDT--LEVGNYSF YALDNQNLRQLWDWSKH-NLTITRGKLFFHYNPKLCLSEIHKMEEISGTKGRQERTDIAL KTNGDQASCENEL--LKFSYIRTSSDKIMLKWEPYWPP---DFRDLLGFMLFYKEAPYRN VTEFDGQD-ACGSNSWTVVDIDPPPRSTDPKSQ--AHPGWLMRSLKPWTQYAIFVKTLVT FSDERRTYGAKSDIIYIQTNATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVF WERQEEDSELYE-LDYCLKGLKLPSRTWS---------------------PPSELEGSQK HNQSEYDEAAGECCSCPKTDSQILKELE------ESSFRKTFENYLHNVVFV--PRS--- ---------SRKRRALGDEGNVTTAEPTALG----------------FPN-TSTIVPTRS EEPR--------------------PFEKVVNK--ESLVISGLRHFTGYRIELQACNQDFP E-ERCSVAAYISARTMPE--AKADDIVGPVTHEIFENN--IVHLMWQEPKHPNGLIVLYE VSYRRY-------GDE--------------------ELHLCVSRRH--FALERGCRLRGL SPGNYSVRVRATSLAGNGSWTEATYFYVTNYLDVPSNIAKIIIG---PLIFVFLFSVVIG SIYLF-------LRKRQSDGPVGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKITLL RELGQGSFGMVYEGNAKDIIKGEAE--TRVAVKTVNESASMRERIEFLNEASVMKGFACH HVVRLLGVVSKGQPTLVVMELMTHGDLKSHLRSLRPDAENN-PG---RPPPTLQEMFQMA AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMAPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDG-GYLDIPD NCPERLSELMSMCWHFNP-KMRPTFLEVVDLLKDNLHPS------FPEV----------- --------SFFYSEEN---KAPENDELEMEFEDMESV--PLDRSSHCQREE----DGGCP LALKRN-----YEDH-------------MSYSHMNGGKKNGRVLTLP------------- ------RSSPS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------- >S franciscanus ------------------------------------------------------------ ------------------------------------------------------------ --NELFVFIYLF--------------------TVCQSMDIRN-----------------S AEKFSKLENCTVIEGYLQIVLIDHATPSDYAGLS--------------FPKLREITEYFV MFRVKNLQTLRHIFPNLAVIRGDSLFFNYALIIFEMFELQEIGLPSLQAVMRGSVRIEKN INLCYLSTVDWSLVQFQGMENNFIK-GNKDQ-EECFNFCP-----EDDGKRLCRKLTASG -----DVAELCWTNEHCQKGK------PVSC-PRSCNAAGRCCHEQCIGGCSGS-TPSDC TACRHFLHLGVCVGECPNGTFQVSQ----SFQSCSK--------------KLFLGQIRIL IKFLARIILPSRQCKLILSLSLFLLLVC----DGKTIQSVEDAADMRGCTYVHGSLTISV HGR--GTVA-----------------------PWIGCKIYRS------------------ -------------YEEQGKKYTGTGGEFAAEMPKRSPQNLDRVQCKTNQR--LSMMCLFL ASHS---VGNTHRLNLEFNFFGTF---LMVNWSP--PKGKGDVREIVGYILSYREAPQRN VTELDGED-ACGTSLWEVQYIPPTDTST------------FVSNLKPWTQYAFMVR---T YTIAGAQFSARYMIIYSLYPEAEASPPSSLKVISNSSSELIITWKPPEHPNGNLTHYIIS WEPQYLPIHQFEDRDFCRESCIPRTIIIS---------------------SLIHIIAP-- ------YYGQS-SCIS--DTQCIRLTHN------SLIMNKTFLVHYPAHYDL-------- -----------------TTTSFIQPIPITPESEHN-------LNGSLYPSSPATGVNAST TPPS--------------------RVEERVIGLVESFRVTGLEHFTEYFITLQACNSKD- ----CSRAAAMYGRSLPK--ESADQIESAVMINHTSTD--RVHLTWAEPSNPNGIIVIHE IRFEMMDVEVNDVGDERDAYTVVESRSTPKPVTQSTENTECVSAEG--YRRVLGAELLGL KVGNYTAMVRAVSLAGEGPWTKPVMFSVPDITNSSYAKAALILCAK-PVRSCYLLKKPIA EILSY-----IHYPRHIKQSHSHMKQISISKYYIMIIY-----VYVADEWEFPRDKLEII RELGKGSFGMVYEGLAKGILPEEEEI-SRVAIKSVQANASMRDRIEFLNEASYMKLIDAH NVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQQDLPV-ELKNVYSVRALIGMI AQIASGMAYLSSMNFVHRDLAARNVLVGEGNVCKVADFGLARDIYQSDYYRKESGGKLPI RWMAPEALLYGIFTIKSDVWSFGILLWEIVTYGKIPYPGLDNEEVIEYIRQG-YRLPPPE GCPEEMYALMTKCWSYIP-AKRPPFKDISTRLKAYPILKEVALCILLNK----------- ---------LSGPIPQYGAASPMFLECSCRQSITQVISCPAHPQICRPLASK--ASLIYH QITIKP-----CRDHT------------ITSYQSQILFHPSMTMQQDQL----------- -CYL-----PSIYIP--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------- >S purpuratus ------------------------------------------------------------ ------------------------------------MMDGLARPARMGRTSVRSTTLL-- -FFIIFIVCSLFCISNVAG---------ADADGVCKSMDIRN-----------------S AEKFAKLENCTVIEGYLQIVLIDHATPSDYAGLS--------------FPKLREITEYFV MFRVKNLQTLRHIFPNLAVIRGDSLFFNYALIIFEMFELQEIGLPSLQAVMRGSVRIEKN INLCYLSTVDWSLVQFQGMENNFIK-GNKDQ-EECFNFCP-----EDDGKRLCRKLTSSG -----DVAELCWTNEHCQKVC------PASC-PRSCNAAGRCCHEQCIGGCSGS-TASDC TACRHFLHLGVCVGQCPNGTFQFKNRHCITGERCPS--------------GWRLFNEKCT EECPGGYMPDFNDSRHCLPCTGTCPKVC----KGKTIQSVEDAADMRGCTYVHGTLTISV HGR--GNVLKELERNLGMIEVISDALIVRRANSLVSLNFLRNLRKIEGRDGGLEMDQYSL YVLANNNLQQLFDFSQHPNITIVNGKFFFHYNPKLCYSEIEELHNLTGIKEPLSNVDVSL SSNGDQVACNTHRLNLQFNFFGTF---LMVNWSP--PKGKGDVREIVGYILSYREAPQRN VTELDGED-ACGTSLWEVQYIPPTETST------------FVSNLKPWTQYAFMVR---T YTIAGAQFSARSNIEYRLTPEAKASPPSSLKVISNSSSELIVTWKPPEHPNGNLTHYIIT WEPQYLPIHQFDDRDFCREKL-PNLRKSE---------------------SSTEMETSED EDTNTTMVGAG-CCMCPIDPDELARREE------DARFQKDFENQLHNTIYKRRPDTRRR KKRDVPGSAIQDAGTTPTTTSFITPIPTTPTSGFN-------LNGSLYPSSPATGVNAST TSPS--------------------RVEERVIGLVESFHVTGLEHFTEYFITLQACNSKD- ----CSRAAAMYGRSLPK--ESADQIESAVMINHTSTD--RVHLTWAEPSNPNGIIVIHE IRFEMMDVEVDDVGDERDAYTVVESHSTPKPVTQSTENTECVSAEG--YKRVLGAELLGL KVGNYTAMVRAVSLAGEGPWTKPVMFSVPDITNNPTYEPDKALPPMMGVTIAVSIAAVII IIVFIIIFLRWHYRK--DQMPDGVLYASVNPEYMSTSD-----MYVADEWEFPRDKLEII RELGKGSFGMVYEGLAKGILPEEEEI-SRVAIKSVQANASMRDRIEFLNEASVMKLIDAH NVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQQDLPLIDRKSVPTLEQLLNMA AEIADGMSFLAARKYVHRDLSARNCLVSGEGTCKVADFGLARDIYQSDYYRKERGGMLPI RWMAPESVKDGVFQASSDVWSFGILLWEMATLGELPYQGLSNEEAGEYIKGG-NVLRPPE NCPEKMQEIMMACWQYQE-KLRPLFGEIILNLQDYGLLRDS----FAQN----------- ------CFFLNEQL---NASAAPA-DMSSKELETV----SILDQNAKNN-----ENLYTS MSNNKP-----EGAS-------NGGNRAGGSVEVPIVTGPSSSPKDRNGS---------- -LTGNGSIPHGVGVGKCTEC---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------- >L variegatus ------------------------------------------------------------ ------------------------------------------REDNLSINSLKLEVMLRG FLFILNLVLKLL-INIILFT---------LFVTVCKSMDIRN-----------------S AEYFSKLENCTVIEGYLQIVLIDHAKPSDYAGLS--------------FPKLREITEYFV MFRVKNLQTLRHIFPNLAVIRGDSLFFNYALIIFEMFELQEIGLPSLQAVMRGWVRIEKN INLCYLSTVDWSLVQVQGMENNFIK-GNKDQ-EECFNFCP-----EDDGKRLCRKLTATG -----DVAELCWTGQDCQKVC------PVSC-PRSCNEAGRCCHEQCIGGCRGS-TASDC TACRHFLHLGVCVGQCPNRTFQVKNRHCITAEQCPA--------------GWKLFNEKCT QDCPGGYMPDFNDSRHCLPCTGTCPKVC----DGKTIQSVEDAAAMKGCTYVHGSLTISV HGR--GTVVKELEQNLGMIEVVSDALIVRRANSLVSLNFLRNLRRIEGRVGGLEMSEYSL YVLANNNLQQLFDFSQHPNISIGNGKFFFHYNPKLCYSEIEKLHNLTGIKAPLSNIDVSL SSNGDQFAGNTHRLNLEFAFFQSV---LSVRWSP--PKGKGDVREIVGYILSYREAPQRN VTELDGED-ACGTSLWEVQYIPPTETST------------FVANLKPWTQYAFMVR---T YTIAGAQFSARSNIQYLLTPESEASPPSSLNVISNSSSELVITWKPPEHPNGNLTHYIIT WEPRYLFKQQFEDRDFCRQEL-PTLRKSE---------------------SSTEMETSED EDTNTTMVGAG-CCTCPIDPEELRRREE------DARFQKDFENQLHNNIYMAYATSSAT RSG---ASQYIHYAIDDIEVSKLQYELHTPLSKQ---------YKSCYFIYGMILCYIRY ALPA--------------------LIDQHIHSFI---SRYIAHYYRDSQRHHLPYRSWS- ----ASKIISICPMPIARIYESADQIESTVMINHTSTD--RVHLTWAAPTNPNGIVVIHE VRFEMVDPKVDDVGDERDAYTVVESLSTPKPVTQSTENTECVSAEG--YRRVLGAELLGL KVGNYTAMVRAVSLAGEGPWTKPVTFSVPDITNSCYIIAAAVAKSQFPSLSIVQYCHIMH YSYIYSIICYIIYRK--DQMPDGVLYASVNPEYIIISP-----VYVADEWEFPHDKLEII KKLGKGSFGMVYEGLAKGILPDEEDI-SRVAIKSVQANASMRDRIEFLNEASYSK-IEAH HVVRLLGVVSKGQPTYVIMEFMAQGDLKNWLRARRPENQQDLPLIDRKNVPSLRQLIYMA AQIADGMAYLSSQRFVHRDLAARNILVGENYTCKIADFGLARDIYQSDYYRKEGGAKFPI RWMAPESLLYGKFTIKSDVWSFGVLLWEIVTLGRIPYPGLSNAEVPKYIKGG-NSLRPPE NCSPQM-AILFQSWYYEKICLRSSALKNLARQGARCIYA------KEKI----------- --------CFSKPEIYHKIHCSDFYKLPLDLELIPYICMSVLILIHCLQYD---KTLCQK VSLFQS-----ASACC------------LQGVWCVVGDHSKRSIAVP------------- -SELKCRGPQVRGIWTC------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------- >M musculus ------------------------------------------------------------ ------------------------------------------MGFGRGCETTAVPLLVAV AALLVGTAGHLY------------------PGEVCPGMDIRN-----------------N LTRLHELENCSVIEGHLQILLMFKTRPEDFRDLS--------------FPKLIMITDYLL LFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKN NELCYLATIDWSRI-LDSVEDNYIV-LNKDDNEECGDVCPG----TAKGKTNCPATVING -----QFVERCWTHSHCQKVC------PTICKSHGCTAEGLCCHKECLGNCSEPDDPTKC VACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCI PECPSGYTMNSSNL-MCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINI RGG--NNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGET--LEIGNYSF YALDNQNLRQLWDWSKH-NLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIAL KTNGDQASCENEL--LKFSFIRTSFDKILLRWEPYWPP---DFRDLLGFMLFYKEAPYQN VTEFDGQD-ACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVT FSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVY WERQAEDSELFE-LDYCLKGLKLPSRTWS---------------------PPFESDDSQK HNQSEYDDSASECCSCPKTDSQILKELE------ESSFRKTFEDYLHNVVFV--PRKTSS GNGAEDSRPSRKRRSLEEVGNVTATTLTLPD----------------FPNVSSTIVPTSQ EEHR--------------------PFEKVVNK--ESLVISGLRHFTGYRIELQACNQDSP D-ERCSVAAYVSARTMPE--AKADDIVGPVTHEIFENN--VVHLMWQEPKEPNGLIVLYE VSYRRY-------GDE--------------------ELHLCVSRKH--FALERGCRLRGL SPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIG---PLIFVFLFSVVIG SIYLF-------LRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLL RELGQGSFGMVYEGNAKDIIKGEAE--TRVAVKTVNESASLRERIEFLNEASVMKGFTCH HVVRLLGVVSKGQPTLVVMELMAHGDLKSHLRSLRPDAENN-PG---RPPPTLQEMIQMT AEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPV RWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDG-GYLDPPD NCPERLTDLMRMCWQFNP-KMRPTFLEIVNLLKDDLHPS------FPEV----------- --------SFFYSEEN---KAPESEELEMEFEDMENV--PLDRSSHCQREEAGGREGGSS LSIKRT-----YDEH-------------IPYTHMNGGKKNGRVLTLP------------- ------RSNPS------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------- >C elegans MTRMNIVRCRRRHKILENLEEENLGPSCSSTTSTTAATEALGTTTEDMRLKQQRSSSRAT EHDIVDGNHHDDEHITMRRLRLVKNSRTRRRTTPDSSMDCYEENPPSQKTSINYSWISKK SSMTSLMLLLLFAFVQPCAS---------IVEKRCGPIDIRNRPWDIKPQWSKLGDPNEK DLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQPRYSQDEFITFPHLREITGTLL VFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDL-EIGLDKLSVIRNGGVRIIDN RKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKGESKCHYLEEKN QEQGVERVQSCWSNTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERVNDATAC HACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLNPVLSN----KTVPIKATAGLCS DKCPDGYQINPDDHRECRKCVGKCEIVCEIN---HVIDTFPKAQAIRLCNIIDGNLTIEI RGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRIEAKS--LFRNLYAI TVFENPNLKKLFDSTTD--LTLDRGTVSIANNKMLCFKYIKQLMSKLNIP--LDPIDQSE GTNGEKAICEDMAINVSITAVNADS--VFFSWPSFNIT-DIDQRKFLGYELFFKEVPRID ENMTIEEDRSACVDSWQSVFKQYYETSNGEPTPDIFMDIGPRERIRPNTLYAYYVAT--Q MVLHAGAKNGVSKIGFVRTSYYTPDPP-TLALAQVDSDAIHITWEAPLQPNGDLTHYTIM WR-ENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLLTMMGH EDQQKTCAATPGCCSCSAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRDTMRVR RSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHISKKKPSSSSTTSTPAPTIASMYALT RKPTTVPGTRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHYTLYAISLSACQNMTV PGASCSISHRAGALKRTKHITDIDKVLNETIEWRFMNNSQQVNVTWDPPTEVNGGIFGYV VKLKSKVDG-------------------------SIVMTRCVGAKRGYSTRNQGVLFQNL ADGRYFVSVTATSVHGAG--PEAESSDPIVVMTPGFFTVEIILG--MLLVFLILMSIAGC IIYYY------IQVRYGKKVKALSDFMQLNPEYCVDNK------YNADDWELRQDDVVLG QQCGEGSFGKVYLGTGNNVVSLMGDRFGPCAIKINVDDPASTENLNYLMEANIMKNFKTN FIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKREDEVFNETDCNFFDIIPRDKFHEWA AQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGDFGMARDLFYHDYYKPSGKRMMPV RWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSNDEVLNYIGMARKVIKKPE CCENYWYKVMKMCWRYSP-RDRPTFLQLVHLLAAEASPEFRDLSFVLTDN---QMILDDS EALDLDDIDDTDMNDQVVEVAPDVENVEVQSDSERRNTDSIPLKQFKTIPPINATTSHST ISIDETPMKAKQ----------REGSLDEEYALMNHSGGPSDAEVRTYAGDGDYVERDVR ENDVPTRRNTGASTSSYTGGGPYCLTNRGGSNERGAGFGEAVRLTDGVGSGHLNDDDYVE KEISSMDTRRSTGASSSSYGVPQTNWSGNRGATYYTSKAQQAATAAAAAAAALQQQQNGG RGDRLTQLPGTGHLQSTRGGQDGDYIETEPKNYRNNGSPSRNGNSRDIFNGRSAFGENEH LIEDNEHHPLV IRS >H sapiens MASPPESD--------GFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKK WRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQ LHNRAKGHHDGAAALGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFK-EVWQVILKPK GLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVT GPGEFWMQVDDSVVAQNMHETILEAMRAM--SDEFRPRSKSQSSSNCSNPISVPLRRHHL NNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSP STNRTHAHRHRGSARLHPPLNHSRSIPMPASRCSPSATSPVSLSSSSTSGHGSTSDCLFP RRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMG GKGPSTLTAPNGHYILSRGGNGHRCTPGTGLGTSPALAGDEAASAADLDNRFRKRTHSAG TSPTITHQKTPSQSSVASIEEYTEMMP-AYPPGGGSGGRLPGHRHSAFVPTRSYPEEGLE MHPLERRGGHHRPDSSTLHTDDGYMPMSPGVAPVPSGRKGSGDYMPMSPKSVSAPQQIIN PIRRHPQRVDPNGYMMMSPSGGCSPDIGGGPSSSSSSSNAVPSGTSYGKLWTNGVGGHHS HVLPHPKPPVESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLP RSFKHTQRPGEPEEGARHQHLRLSTSSGRLLYAATADDSSSSTSSDSLGGGYCGARLEPS LP-HPHHQVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQQQQPLLHP PEPKSPGEYVNIEFGSDQSGYLSGPVAFHSSPSVRCPSQLQPAPREEETGTEEYMKMDLG PGRRAAWQESTGVEMGRLGPAPPGAASICRPTRAVP--SSRGDYMTMQMSCPRQSYVDTS PAAPVSYADMRTGIAAEEVSLPRATMAAASSSSAASASPTGPQGAAELAAHSSLLGGPQG PGGMSAFTRVNLSPNRNQSAKVIRADPQGCRRRHSSETFSSTPSATRVGNTVPFGAGAAV GG-GGGSSSSSEDVKRHSSASFENVWLRPGELGGAPKEPAKLCGAAGGLENGLNYIDLDL VKDFKQCPQECTPEPQPPPPPPPHQPLGSGESSSTRRSSEDLSAYASISFQKQPEDRQ >H glaber MASPPDTD--------GFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKK WRHKSSAPKRSIPLETCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQ LHNRAKGHHDGAAVPGAGGGGGSCSGSSGVGEAGEDLSYGDVPPGPAFK-EVWQVILKPK GLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVT GPGEFWMQVDDSVVAQNMHETILEAMRAM--SDEFRPRSKSQSSSNCSNPISVPLRRHHL NNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSP STNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFP RRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMG GKGASTLTAPNGHYILSRGGNGHRYLPGAGLGTSPALAGEEAASAADLENRFRKRTHSAG TSPTISHQKTPSQSSVASIEEYTEMMP-AYPPGGGSGGRLPSYRHSAFVPTHSYPEEGLE MHPMEQRGGHPRPDSSGLHTDDGYMPMSPGVAPVPGSRKGSGDYMPMSPKSVSAPQQIIN PIRRHPQRVDPNGYMMMSPSGSCSPDIGGG-SSSSSSISAAPSGSSYGKLWTNGVGGHHS HALSHPRPPVESGGSKLLPCTSDYMNMSPVGDSNTSSPSDCYYGSEDPQHKPVLSYYSLP RSFKHTQRPGEPEEGARHQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGYCGARPEAG PP-HPHHHVLQPRLPRKVDTAAQSNSRLARPTRLSLGDPKASTLPRARE--QQQPPLVHP PEPKSPGEYVNIEFGSGQPGYFSGPMASRSFPSVRC--QLQPAPREEETGTEEYMNMDLG PGRRAAWQESSGAETGRAGPAPPGAASVCRPTRAVP--SSRGDYMTMQMGCPRQNYVDTS PVTPVSYADMRTGI-AEEVSLPRATVAAPSSSSAAPASPTAPQGAAELAAHSSLLGGPQG PGGVSAFTRVNLSPNRNQSAKVIRADAPGCRRRHSSETFSSTPAATRAGNTVPFGGGAAV GG-SGGSSSSSEDVKRHSSASFENVWPRPGEQGGAPKDTAQACAAAGGLENGLHYIDLDL VKDLKQRPQERPSQLQAPLPPPPHHPLGSSESSSTSRSSEDLSAYASISFQKQPEDRQ >M brandtii MASPTETE--------GFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKK WRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQ LHNRAKSHHDGASAPGTGGGGGSCSGSSGVGEAGEDLSFGDSNPGPAFK-EVWQVVLKPK GLGQTKNLIGIYRLCLTSKTISFVKLNTEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVT GPGEFWMQVEDSVVAQSMHETILEAMRAM--SDEFRPRSKSQSSSNCSNPISVPLRRHHL NNPPPSQVGLTRRSRTESITATSPASLVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSP STNRTHAHRHRGCSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFP RRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMG GKGASTLAAPNGHYILPRGGNGHRYLPATGLGTNSALAGDEAASAADLDNRFRKRTHSAG TSPTISHQKTPSQSSVASIEEYTEMMP-ACPPGGGSGGRLPGYRHSAFLPTQSYPEEGLE MHPLERRGGHSRPDTSTLHTDDGYMPMTPGVAPVPGSRKGSGDYMPMSPKSVSSPQQIIN PLRRHPQRVDPNGYMMMSPSGSSSPDTGGGPSSSNS---AAPSRSSYGKLWTNGVGGHHA HPLPPSKLPSESSGGKLLPCTGDYMNMSPVGDSNTSSPSDCYCGPEDPQHKSVLSYCSLP RSFKHTQRPGDLEETARHQHLRLSSSSGRLLYAAAAEDSSSSTSNDSLGGGYCGVRPEPS LPQHLHHQVLQSHLPRKVDSAAQTNSRLARPTRLSLGDPKASTLPRARE--QQQPALLLP PEPKSPGEYVNIEFGSDQPGYLSGPVASHSSPSVRCPSQLQPAPREEESGTEEYMNMDLG PGRRATWQESPVVQPSRVGPAPPGTASTCRPTRAVPSTSTRGDYMTMQMGCPHQSYVDTS PVAPVSYADIRTGI-VEEASLPGAIAAAPSSSSTASASPTAPQGAGELVA-------PQG SGGTSAFTRVNLSPSGNQSAKVIRADPQGCRRRHSSETFSSMPSTPRAGNMVPSG-GAAV GG-SSGGSSSIEDVKRHSSASFENVWLRPGELGGAPKEQAQVCGAAGGLENGLNYIDLDL VKDFKQHPQEHPRQVQHPQPPTLRHPPGSSESSSTSRSREDVSAYASISFQKQPEDLQ >S farnciscanus MSSQKENVPIPCGVELSIGDIEKSGYLRKLKTMRKKYFVLRSESNT-GPSRLEYYDNEKK FRL-GGEAKRTVPLSACFNINKKSDAKHKHAIALYTRDDCFSLVADDEESQQEWLRALLE ----------------------------------QQRAGGDGKPVPAFE-HVWQVTVKPK GLGSSRQLSGIYRLCLTTSTISLVRMNSENEGLELQLSAIRRCGHSDCFFFMEVGRQSVT GPGELWMQVEDTVIAQSIHEASIRAMRSVKQQEEMRPRSHS------------------- ------------------------STMSSGNPGS-------------------------- ------------------------------------------------------------ DSKSHSASGSRRQSNTL------------------------------------------- -------------------GPSWR----------------TRCDSMPVPNRAM------- ------------------------------------------------------------ ----------------------------------PGSRSG-------------------- ------------------------------------------------------------ --------------------------------SRSRGNSEGEDGQSKEEHAIASS--SSP ISL--------------------------------------------------------- ------------------------------------------------------------ -----------LKFGN----------------------KLRPRTSSE------------- -----------------------------------------GE----------------- -----------KGM-------------------KAP------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >S purpuratus MSSQKENVPIPCGVELSIGDIEKSGYLRKLKTMRKKYFVLRSESIT-GPSRLEYYDNEKK FRL-GGEAKRTVPLSACFNINKKSDAKHKHAIALYTRDDCFSLVADDEESKQEWLRVLLE ----------------------------------QQRAGGDGKPVPAFE-HVWQVTVKPK GLGSSRQLSGIYRLCLTTSTISLVRMNSENEGLEFSLSAIRRCGHSDCFFFMEVGRQSVT GPGELWMQVEDTVIAQSIHEASLEAMRSVKQQEEMRPRSHS------------------- ------------------------STMSSGNPGS-------------------------- ------------------------------------------------------------ DSKSHSASGSRRQSNTL------------------------------------------- -------------------GPSWR----------------TRCDSMPVPNRAM------- ------------------------------------------------------------ ----------------------------------PGSRSG-------------------- ------------------------------------------------------------ --------------------------------SRSRGNSEGEDGQSKEEHAIASS--SSP VSL--------------------------------------------------------- ------------------------------------------------------------ -----------LKFGN----------------------KLRPRTSSE------------- -----------------------------------------GE----------------- -----------KGM-------------------KAPDSPTKTRGRFSIPSLTSRSSLSSG PIFVMVLDLSILRSVGSIFQKLLPTKKDFMKVKV-------------------------- ------------------------------------------------------------ ---------------------------------------------------------- >L variegatus MSSQKENVPIPCGVELSIGDIEKSGYLRKLKTMRKKFFVLRSESNT-GPSRLEYYDNEKK FRL-GGEPKRTVPLSACFNINKKSDAKHKHAIALYTRDDCFSLVADDEESQQEWLRAQFQ ------------------------------------YPYCHAHILYAIKEHVWQVTVKPK GLGSSRQLSGIYRLCLTTSTISLVKMNSENQGLEFSLSAIRSCAHSDCFFFMEVGRQSVT GPGELWMQVEDTVIAQSIHEASLEVFHQP------------------------------- ---------------------------SCDKPGGCFIKL--------------------- ------------------------------------------------------------ ---------------FV------------------------------------------- -------------YVKSDYRNDWSFLVVNGI-----FIGDIACKK--------------- ------------------------------------------------------------ --------------------------MYPTCLIISHFHYC-------------------- ------------------------------------------------------------ --------------------------------ANHSKKTNTSCSLYQSHYCILCVPLSFI ISL--------------------------------------------------------- ------------------------------------------------------------ -----------LKFGN----------------------KLRPRTSSE------------- -----------------------------------------GE----------------- -----------KGM-------------------KAP------------------------ -------------------------DRYVC------------------------------ ------------------------------------------------------------ ---------------------------------------------------------- >M musculus MASPPDTD--------GFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKK WRHKSSAPKRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQ LHNRAKAHHDGAG----GGCGGSCSGSSGVGEAGEDLSY-DTGPGPAFK-EVWQVILKPK GLGQTKNLIGIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVT GPGEFWMQVDDSVVAQNMHETILEAMRAM--SDEFRPRSKSQSSSSCSNPISVPLRRHHL NNPPPSQVGLTRRSRTESITATSPASMVGGKPGSFRVRASSDGEGTMSRPASVDGSPVSP STNRTHAHRHRGSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFP RRSSASVSGSPSDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMG GKGASTLAAPNGHYILSRGGNGHRYIPGANLGTSPALPGDEAAGAADLDNRFRKRTHSAG TSPTISHQKTPSQSSVASIEEYTEMMPAAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLE MHHLERRGGHHRPDTSNLHTDDGYMPMSPGVAPVPSNRKGNGDYMPMSPKSVSAPQQIIN PIRRHPQRVDPNGYMMMSPSGSCSPDIGGG-SSSSSSISAAPSGSSYGKPWTNGVGGHHT HALPHAKPPVESGGGKLLPCTGDYMNMSPVGDSNTSSPSECYYGPEDPQHKPVLSYYSLP RSFKHTQRPGEPEEGARHQHLRLSSSSGRLRYTATAEDSSSSTSSDSLGGGYCGARPESS LT-HPHHHVLQPHLPRKVDTAAQTNSRLARPTRLSLGDPKASTLPRVREQQQQQQSSLHP PEPKSPGEYVNIEFGSGQPGYLAGPATSRSSPSVRCPPQLHPAPREE-TGSEEYMNMDLG PGRRATWQESGGVELGRIGPAPPGSATVCRPTRSVP--NSRGDYMTMQIGCPRQSYVDTS PVAPVSYADMRTGIAAEKASLPRPTGAAPPPSSTASSSVTPQGATAEQATHSSLLGGPQG PGGMSAFTRVNLSPNHNQSAKVIRADTQGCRRRHSSETFS---APTRAGNTVPFGAGAAV GGSGGGGGGGSEDVKRHSSASFENVWLRPGDLGGVSKESAPVCGAAGGLEKSLNYIDLDL AKE---RSQDCPSQQQSLPPPPPHQPLGSNEGNSPRRSSEDLSNYASISFQKQPEDRQ LDLR >H sapiens ------MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQD GSDESQ-----------------------------------------------------E TCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKC ISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQC---NSSTCIPQLWACDNDPDCEDGSD EWPQRCRGLYV--FQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVAT- --CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLD KVCNMARDCRDWSDEPIKE-CGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRR- ---CEDIDECQD-PDTCSQLCVNLEGGYKCQCEEGFQLD-PHTKA-CKA--VGSIAYLFF TNRHEVRKMTLDRSEYTSLIPNLRNVVALD---TEVASNRIYWSDLSQRMICSTQLDRAH GVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPR AIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDS KLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVN LLAENLLSPEDMVLFHNLTQPRGVNWCERTT-LSNGGCQYLCLPAPQINPHSPKFTCACP DGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVR-TQHTTTRPVPDTSRLPGATPG LTTVEIVT-MSHQALGDVAGRGN-EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLK NINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA >H glaber MQCAPRMRTAGPVLRYGALLLCLAAGAA-EDKCARNEFQCWDGKCISYTWVCDGRAECQD GSDESQ-----------------------------------------------------E TCMAATCKPGDFSCGGRLNRCIPSSWRCDGHEDCNNGADEQGCPTRTCPEDEFHCQDGRC ISQQFLCDGDRDCLDGSDEVTCSVTTCGPANFQC---NSSACIPQLWACDGDSDCSDGSD EWPQRCEGRDTSAAQGANGPCSSLEFHCRSGECIHSSWHCDGAHDCKDKSDEEDCVVAT- --CRPDEFQCADGTCIHGSRQCDQEHDCRDQSDEVGCINVTLCEGPNKFKCHSGECITLD KVCNAARDCRDWSDEPLKE-CGTNECLDNNGGCSHICKDLKIGYQCLCPSGFHLADQWQ- ---CKDIDECQE-PDTCSQLCVNLEGSYKCECEDGFQMD-PSTKT-CKA--VGSVAYLFF TNRHEVRKMTPDRSQYASLLSNLKYAVALD---AEVASSRLYWSDLSHRKIYSTRISAAP GS-AHDTVIDGDLQAPDGLAVDWVHRNIYWTDSVPGTVSVADTRGVKRRTLFQRKGSKPR GIVVDPVHGFMYWTDWGTPAKIEKGGLNGVDMYSLVTEDIEWPNGITLDLSSSRLYWVDS KLHSIFSINVNGRNRKTILEDEKQLAHPFSLAIFEDKIFWTDIINEAIFSVNRLTGLDVH LVAENLSSPEDIVLFHNVTQPKGVNWCERTA-LPNGGCQYLCLPAPQINSHSPKFTCVCP DGMVLAKDMRSCLTEAEPSVTTPVHPTARPEASSTAVR-PKHADQWPAPSTSGRPVATSG LTTAASVT-MSHQVVGNAAGRG---EKPHSVGALTIVLPIGLVALLCLGAFLLWKNWRLK NINSINFDNPVYQKTTEDEVHICRSQDGYIYPSRQRVSLEDDVV >M brandtii ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------MREKRRSAASCTPP-------------------TGDVPAT---- -------------------------------KCIHRSWRCDGSADCKDKSDEENCAVAT- --CRPDEFQCFDGTCIHGSQQCDREHDCKDMSDELGCINVTLCEGPNKFKCHSGECITMD KVCNSVRDCRDWSDEPLKE-CETNECLTNKGGCSHLCKDLKIGYECLCPEGFRLADQRR- ---CEDIDECED-PDACSQLCVNSVGSYQCKCEEGFRLD-PFTKA-CKA--VDTIAYLFF TNRHEVRKMTLDRSEYTSLIPNLKNVVALD---VEVHANRVYWSDLSQRKIYSTQIHRES NS-SYDTIIDEGLQAPDGLAVDWIHGNLYWTDSMLGTVSVANTKGVKRKTLFKEKGSKPR AIVVDPRHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTEDIQWPNGITLDLSSDRLYWVDS KLHSISSIDLTGRHRKTILEDKKRLAHPFSLAIFEDKVFWTDIINEAIFSANRHTGSDIN LMAENLMSPEDIVLSHRLTQPKGINWCETTF-YSYGGCQYLCLPAPQINSYSPKFTCACP DGMLLAEDRRSC--RPEPVVTTRG------------------------PNMTRSTVTTPE LTTAKMVTKAPPQASEDVPIKEDRKERPRGVGWLYIVLPIGLLTLLCFGAFLLWKNWRLK SINSIHFDNPVYQKTTEDEVHICHSQDGYTYPSRQMVRMEDDMA >S franciscanus LLLSLLLSSHCITLILL------FYSGS-AILCGEYQFRCQNGHCIPSYWQCDNYDDCGD NSDEQSCPKMYMYSLEYSY---------SYIIHCRIRIRMIYYIPCPNPSLRIAT----S HAETLTCSPSQFSCGPGKN-CIPLTWRCDRDVDCPSGADEHNCDALTCASNQFTCNNKKC VTTRWVCDGDNDCGDGSDEINCPSLTCAPDEFECTGTNETTCIPNRWKCDGEIDCRDGSD ESSTHCSTATT--------PCSAGQFQCASGRCIHAAWKCDGERDCGDGSDEESCCLVTP SPCAASEYRCDDGVCIPGDVECDGTQQCADGSDEANCNAPAECNPITHFRCSNSTCLPMV RVCNGIPECPNNEDEPGQEICGKNECLTNNGGCSHTCMDLAIGHVCTCNAGYALVNETQ- ---CVDINECKTTLGICSQRCYNLPGSYKCDCDENYTLEHVNDRGHCKANPEFGTPKLLI ANRHDIRIFDLRTSSEDYIRRSLHSAVAVE---FDSASNTVFWTDVGLEVVAKFGKQILD FF--EMSYISD-VLLPDGVAVDWITRNLYWTDSGRDTIEVSRLDGSSRTVLIDEDLDEPR AIALDPEGG-MFWSDWGLGV-IERAGMNGQGREAIVTDEIYWPNGLTLDYTLDMLYWIDA KESSISSVDFMGGNRRVVLAGQGRLPHPFGIAVFEDYIYWTDWESKSIERANKFTGSNQT TILSGLSDAMDVIVVNPLRQAPS-----------------------K------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------- >S_purpuratus ------MGTYTLSLILLGLLACVFSAVN-GNLCGENQFRCDNNKCIPSVWKCDNEDDCGD NSDETVCGQLTCSSAEFECVGSGAGNGGSTCIPARWRCDGDS--DCPDGSDEIA------ -CQTLTCSPSQFSCGPGKN-CIPLTWRCDRDVDCPSGADEHNCDALTCASNQFTCNNKKC VTTRWVCDGDNDCGDGSDEINCPSLTCAPDEFECTGHNETTCIPNRWKCDGDIDCRDGSD ESSTHCSGPTV--------PCSAGHFQCTSGECVHNSWKCDGERDCFDGSDEDSCPLVTP SPCAANEYQCDNGVCIPGDVECDGTQQCADGSDEANCNAPAECNPTTHFKCSNSTCLPMV RVCNGIPECPNNEDEPGQEICGRNECLTNNGGCSHTCLDLAIGHVCTCNAGYTLVNETQ- ---CVDINECKTTLGICSQRCYNLPGSYKCDCDENYTLENVNDRGHCKANPEFGAPKLLI ANRHDIRIFDPSTSSEDYIKRSLHSAVAVE---FDSASNTVFWTDVGLEVVSKTQLQAEN EV--VPVVVTDKVKTPDGIAVDWINKLLYWTDTGVDNIVVSNFEGTRHTVLISSNLDEPR AIAVDPESGLMFWSDWGLGV-IERAGMNGQGRTAIVTEGVSWPNGLTLDYTLDMLYWIDA KESSISCVDFMGGNRRVVVAGQGRISHPFSIAVFEDYIYWTDWTKESIERADKFTGSNQT TILSGVSDAMDVIVVNPLRQAPY-----------------------Q------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------- >L variegatus SVIYIVYCPYRVIQSLM------FSFTL-GNLCGGNQFTCANNKCIPSVWKCDNEDDCGD NSDELVCGKLEASIFILYIILP------PYVAQTKAHAKA----KCASPHYGYIHSLIIA HTESLTCAPNQFSCGPGKN-CIPLTWRCDHDVDCQTGADEHNCDALTCSANQFTCENKKC ITTRWVCDGDNDCGDSSDEVNCPSLTCAPDQFECTGANETTCIPGRWKCDGDIDCRDGSD ESTTHCSDAAI--------PCPQGHFQCNSGECVRLSWKCDGEQDCFDGSDEESCAVITP TPCAPDEFQCANGVCIQGDVECNNVEECADGSDEANCNGPVDCNPTTHYRCKNSTCLPWV RVCNGIPECPDNEDEPGQEICGEQRI--------HYIYQIIYAKPYHSKSKYIWSKYHNI QPEVIIIQVPKSIASYYHRPCVKI-------------IHYPKQLIYCYYHAVRAIPQCQI KMYVSNRISHINQVVCFYCFQYLFEAIFIDCLVFESCIRCL--NASGCYLSNSSQLVAEN GV--EPVMVTNKVKTPDGIAVDWITKNLYWTDAGYDRIEVSNLDGTSRTVLISSDLDEPR AIAVDPESGLMFWSDWGLGV-IERAGMNGQHRTAIVTEKIQWPNALTVDYTLDRIYWIDA KESSISSVSWMGTNRRVILSGHGRLPHPFAIAVFEDYIYWTDWHTKSIYRANKFTGQDQT IIQGGLHDPMDIHVFHPQRQVPG-----------------------K------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------- >M_musculus ------MSTADLMRRWVIALLLAAAGVA-EDSCSRNEFQCRDGKCIASKWVCDGSPECPD GSDESP-----------------------------------------------------E TCMSVTCQSNQFSCGGRVSRCIPDSWRCDGQVDCENDSDEQGCPPKTCSQDDFRCQDGKC ISPQFVCDGDRDCLDGSDEAHCQATTCGPAHFRC---NSSICIPSLWACDGDVDCVDGSD EWPQNCQGRDT-ASKGVSSPCSSLEFHCGSSECIHRSWVCDGEADCKDKSDEEHCAVAT- --CRPDEFQCADGSCIHGSRQCDREHDCKDMSDELGCVNVTQCDGPNKFKCHSGECISLD KVCDSARDCQDWSDEPIKE-CKTNECLDNNGGCSHICKDLKIGSECLCPSGFRLVDLHR- ---CEDIDECQE-PDTCSQLCVNLEGSYKCECQAGFHMD-PHTRV-CKA--VGSIGYLLF TNRHEVRKMTLDRSEYTSLLPNLKNVVALD---TEVTNNRIYWSDLSQKKIYSALMDQAP NL-SYDTIISEDLHAPDGLAVDWIHRNIYWTDSVPGSVSVADTKGVKRRTLFQEAGSRPR AIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIHSLVTENIQWPNGITLDLSSGRLYWVDS KLHSISSIDVNGGNRKTILEDENRLAHPFSLAIYEDKVYWTDVINEAIFSANRLTGSDVN LVAENLLSPEDIVLFHKVTQPRGVNWCETTALLPNGGCQYLCLPAPQIGPHSPKFTCACP DGMLLAKDMRSCLTEVDTVLTTQGTSAVRPVVTASATRPPKHSEDLSAPSTPRQPVDTPG LSTVASVT-VSHQVQGDMAGRGN-EEQPHGMRFLSIFFPIALVALLVLGAVLLWRNWRLK NINSINFDNPVYQKTTEDELHICRSQDGYTYPSRQMVSLEDDVA >SIG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------+--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MnSOD >H sapiens MLSRAVCGTSRQLAPALGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHA-AYV NNLNVTEEKYQEALA---------------------------------------KGELLE AIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPL LGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK- >H glaber MLPYAACSASRRLAPALGLLGVRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHA-AYV NNLNATEEKYQEALVKGDVTTQVALQPALRFNGGGHINHTIFWTNLSPNGGGEPKGELLE AIKRDFGSFDKFKEKLTAVSVGVQGSGWGWLGFNKEQGRLQIAACSNQDPLQGTTGLIPL LGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK- >S franciscanus ------------------------------------------------IHHSHSSNPILI VDILLVTINLYSVPSLGDISTIISLQAALRFNGGGHINHTIFWQNLSPDGGGEPTGILLN VIKKDFGSFDDMRSKLSAATVAIQGSGWGWLGYNKGTRSLQIATCPNQDPLKATAGLIPL FGIDVWEHAYYLQYKNVRPDYVKAIFNIANWSDVERRLADAMTT >S purpuratus ----------------------------------------------MELHHKKHHN-TYV TNLNVAEEALEHAVEAGDISTIISLQAALRFNGGGHINHTIFWQNLSPDGGGEPTGELLN VIKKDFGSYDDMRSKLSAATVAIQGSGWGWLGYNKGTRSLQIATCPNQDPLKATTGLIPL FGIDVWEHAYYLQYKNVRPDYVKAIFNIANWSDVEKRLTDAMTT >L variegatus -----------------------------------------------GDDTVPVGNVTFV EVVLLVNIYIILDIFLGDISGIISLQSALRFNGGGHINHTIFWQNLSPDGGGEPTGELLS AIKKDFGSYDDMRAKLTAATVAIQGSGWGWLGYNKGTGSIQIATCANQDPLQATTGLVPL FGIDVWEHAYYLQYKNVRPDYVKAIFNIANWVDVERRLRDAMTS >M musculus MLCRAACSTGRRLGPVAGAAGSRHKHSLPDLPYDYGALEPHINAQIMQLHHSKHHA-AYV NNLNATEEKYHEALAKGDVTTQVALQPALKFNGGGHINHTIFWTNLSPKGGGEPKGELLE AIKRDFGSFEKFKEKLTAVSVGVQGSGWGWLGFNKEQGRLQIAACSNQDPLQGTTGLIPL LGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYTACKK- MTH >S franciscanus ------------------------------------------------IYQDISFPP--- -------------ESYVRYLNG-------SVRLC-------------------------- -----------------------WTGPDPPEPV------------------SMFQY---- --SKGQNILNLITI----------------------------TLSSICLLATLVTYCIFK PLRNLQGISIMSFISALLVAQVMLQYIAPKMVSLPTV-CTIAAIITHYLLLVVFTWTNIL AWDLVRHFASSSFLPKRHGEKRRLIGYLTIGWCLPLII----VVPCLIVQVQNPSLFRYG KIGTSCWIY-QARAIVLAFLVPVAVSFLVNIILFSFTAYGVHKSKRD-SSVLHEGAQERR KELFHE---LVVHFQISTLLGFTWLFGFVAAFAKVTALW-YIFIILNSL---QGVFIFIA FGANKRVRKLWRKKMRESKSVTTSTSSSGSSGSSSDSTSDG >S purpuratus ------------------------------------------------IYQDISFPP--- -------------ESYVRYLNG-------SVRLC-------------------------- -----------------------WTGPDPPEPV------------------SMFQY---- --SKGQYILNLILL----------------------------VLSSICLLATLITYCIFK PLRNLQGLSIMSFVSALLVAQLMLQFIAPNMVSLPTV-CTIAAIITHYFLLAIFAWTNIL AYDLFRCFASSSFLPKRHSQKTRLICYFTFGWCLPLVI----VVPCLITQVQNPSLFRYG KIGTSCWIY-QARAIVLAFLVPVAASFLVNFVFFLLTAYGVHKSKRD-SSVLHTGVQERR KEIFTE---LAVHFKISCLLGFGWSFGFIGAFAQSAAVW-TIFIITSSL---QGIFVFIF FGANQRVRGLWRKKIYGSKARGSTTTGTSSTSVGLRDMSQK >L variegatus ------------------------------------------------IYQEISFPP--- -------------ESYVRYRNG-------SVRLC-------------------------- -----------------------WTGPDPPEPV------------------SMFAY---- --SRGQYILNAILF----------------------------TLSSICLLATLITYCIFK PLRNLQGISTMNFATALFIAQVMLQFIAPNMSSIPIA-CTIAAAITHYSLLAAFTWTNIL AWDLVRHFASSSFLPKRHKETRRLIVYHTIGWCVPLII----IVPCLIVQSQNPSLYRYG KIGSSCWIY-QAMGIVLAFLVPVAVSFLINIVLFLLTAYGVHKSKRD-SSILHKSAKEQR KQLFQE---LLVHFQISCLLGFTWSFGFIAAFANVAALW-YIFIILNSL---QGVFIFIA FGANKRVRDLWRKKVCGSAAQTSSSSSSKTSSTSPGSTTFS >D melanogaster MKTLLVLRISTVILVVLVIQKSYADILECDYFDTVDISAAQKLQNGSYLFEGLLVPAILT GEYDFRILPDDSKQKVARHIRGCVCKLKPCVRFCCPHDHIMDNGVCYDNMSDEELAELDP FLNVTLDDGSVSRRHFKNELIVQWDLPMPCDGMFYLDNREEQDKYTLFENGTFFRHFDRV TLRKREYCLQHLTFADGNATSIRIAPHNCLIVPSITGQTVVMISSLICMVLTIAVYLFVK KLQNLHGKCFICYMVCLFMGYL---FLLLDLWQISISFCKPAGFLGYFFVMAAFFWLSVI SLHLWNTFRGSSHKANRFLFEHRFLAYNTYAWGMAVVLTGITVLADNIVENQDWNP-RVG HEG-HCWIYTQAWSAMLYFYGPMVFLIAFNITMFILTAKRILGVKKDIQNFAHR--QERK QKLNSDKQTYTFFLRLFIIMGLSWSLEIGSYFSQSNQTWANVFLVADYLNWSQGIIIFIL FVLKRSTWRLLQESIRGEGEEVNNSEEEISLENTTTRNVLL MTOR >H sapiens MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWY-RHTFE EAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKY CK------DLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPAK STLVESRCCRDLMEEKFDQVCQ-WVLKCRNSKNSLIQMTILNLLPR------LAAFRPS- AFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPP KDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLS RQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLT-TLPEASDVGSITL ALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVV SQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQV FEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNA PRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIII MDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREA IRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLD EFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVC DGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALG GEFKLYLPQLIPHMLRVFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDA PEAPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQL GKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDA LASGPVETGPMKKLHVSTINLQK-------------AWGAARRVSKDDWLEWLRRLSLEL LKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIA EVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPA ILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNK DDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEE YTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMV SCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMR TWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKI DAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPK VLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTA ATTAATATT--TASTEGSNSESEAESTENSPTPSPLQKKVTEDLSKTLLMYTVPAVQGFF RSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTP RPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQA MMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETS FNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPK LLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGH EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL IRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPS SEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTRE KFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW RLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKTGTTVPESIHSFIGDGLVK PEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW---- ------------------C-----------------------PFW--------------- ------------ >H glaber MLGTGPAAATTAASTSSNVSVLQQFASGLKSRSEETRAKAAKELQHYVTMELREMSQEES TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSSDP VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWY-RHTFE EAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKY CK------DLMGFGTKPRHITPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGASPSPAK PTLVESRCCRDLMEEKFDQVCQ-WVLKCRNSKNSLIQMTILNLLPR------LAAFRPS- AFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPP KDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLS RQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLA-TLPEASDVGSITL ALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVV SQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQV FEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNA PRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIII MDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREA IRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLD EFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVC DGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALG GEFKLYLPQLIPHMLRVFMHDNSPGRSVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDA PEVPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQL GKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMQRSGQGDA LASGPVETGPMKKLHVSTINLQK-------------AWGAARRVSKDDWLEWLRRLSLEL LKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIA EVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPA ILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNK DDPELVLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEE YTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMV SCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVNPHEDMR TWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKI DAFQHMQHFVQTVQQQAQHAVATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPK VLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTA ATTAATATTTATASTEGSNSESEAESTEHSPTPSPVQKKVTEDLSKTLLMYTVPAVQGFF RSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTP RPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQA MMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETS FNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPK LLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGH EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL IRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPS SEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTRE KFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW RLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKAGTTVPESIHSFIGDGLVK PEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW---- ------------------C-----------------------PFW--------------- ------------ >M_brandtii MLGTGPAAAAAAAMASSNVSILQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWY-RHTFE EAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKY CK------DLMGFGTKPRHITPFTSFQAVQPQPSNALVGLLGYSSHQSLMGFGASPSPAK STLVESRCCRDLMEEKFDQVCQ-WVLKCRNSKNSLIQMTILNLLPR------LAAFRPS- AFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKIYLPRVLDIIRAALPP KDFAHKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLS RQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLT-TLPEASDVGSITL ALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSVHLISGHAHVV SQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQV FEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNA PRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIII MDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREA IRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLD EFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTYLNVIRVC DGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALG GEFKLYLPQLIPHMLRVFMHDNSAGRTVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDA PEVPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQCPELRPTAMDTLSSLVFQL GKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDA LASGPVETGPMKKLHVSTINLQKAADGFPLSPVELQAWGAARRVSKDDWLEWLRRLSLEL LKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIA EVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPA ILESLISINNKLQQPEAAAGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNK DDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEE YTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMV SCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVNPHEDMR TWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTVHPQVTYAYMKNMWKSARKI DAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPK VLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQAREEKKKLRHASGANITNTTTA SSTAAATTT--ATSTEGSNSESEAESSENSPTPSPLQKKVAEDLSKTLLMYTVPAVQGFF RSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTP RPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQA MMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETS FNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPK LLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGH EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL IRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPS SEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTRE KFPEKIPFRLTRMLTNAMEVTGLDGNYRITCHTVMEVLREHKDSVMAVLEAFVYDPLLNW RLMDTNTKGNKRSRTRTDSYSAGQSVEILNGVELGEPAHKKTGTTVPESIHSFIGDGLVK PEALNKKAIEIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWHTAN SAQSTNLGSWRTRPRILDCKEAGGAHFLTHPSHYLTGPATAFARWAKMGGKGLSSASPVM LRCTTSVQDPDH >S franciscanus ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----FEETGKGEKGLNRDDRAHGALLIINELIRTSSREGE--------------VSLSW SV------DLGSSSNKAKSPT--------GPQLGHNQYVQRALASPLSLVSTSIQPKP-- -RITESRYCLELMQENFDIVSQ----KCFRGIFCLYIHRGIKIYQKFKE---LLSIQFQ- NFPKL-CIDNLCMFCF-----ERERSNAFQAVGLLAVAVKGNITEHLGKILEIVRSSLPH KDIPHRKHKSIIVDPAVFTCISMLARAVGPVIARDVKELLEPMLAVGLRLVFDVPEFAAP VRLTRPYSCIFHSYISYNSMSEFAARYKHTSL-----NSLDSPGTALSSIDSGDLTSTVL ALRTLGNFDFEGHSLTQFVRHCADHFLSSEHKEIRIEAARTCSSLLQPAVN--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VSF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HRVIV HC---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VLF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >S purpuratus ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------MQKPQWY-KQTYE EAEKGFEETGKGEKGLNRDDRAHGALLIINELIRTSSREGERLRQEMEEVSQQQTQHEHS FR------DLGSSSNKAKSPT--------GPQLGHNQYVQRALASPLSLVATGIQPKP-- -RITESRYCLELMQENFDIVCQ-QVLKFCGSRNPLIQQILLNLLPR------LAAFEPK- MFVTS-YLEDTVKYMLISLRRERERSNAFQAVGLLAVAVKGNITEHLGKILEIVRSSLPH KDIPHRKHKSIIVDPAVFTCISMLARAVGPVIARDVKELLEPMLAVGLSPALTAALHDLA KQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGTPRALLSPTGQTGTALSSIDSGDLTSTVL ALRTLGNFDFEGHSLTQFVRHCADHFLSSEHKEIRIEAARTCSSLLQPAVN--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VSF------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HGVIV HY---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --VVF------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >L variegatus ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------EFIG----------------------- ----------------------------------------------------WVDDQTYE EAEKGFEEIGKGEKGLNRDDRAHGSLLIINELIRNSSREGEH-------SSQSKLFYNPT FSDPCLGMDLGSSSNKAKSPT--------GPQLGYNQYVQRALASPLSLGSTSIQPKP-- -RITESRYCLELMQEKFNPVSSVVVLHIRTPK--VARPPIHAYTPRKKSISVFIAISPAI NFLLSKYPEQTIIYFIEYLQIQQERYAIHGTLYHLIIKIH----EYYPSSL--------- --LAFRKHKSIIVDPAVFTSISMLARAVGPVIARDVKELLEPMLAVGLSPALTAALHDLA KQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGTPRALLSPASQTGATLSSVDSGDITSTVL ALRTLGNFDFEGHSLTQFVRHCADHFLSSEHKEIRIEAARTCSSLLQPAVN--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------VSY------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------YWNSI SA---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --KWK------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------ >M musculus MLGTGPAVATASAATSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNSTRIGRFANYLRNLLPSSDP VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWY-RHTFE EAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKY CK------DLMGFGTKPRHITPFTSFQAVQPQQPNALVGLLGYSSPQGLMGFGTSPSPAK STLVESRCCRDLMEEKFDQVCQ-WVLKCRSSKNSLIQMTILNLLPR------LAAFRPS- AFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPP KDFAHKRQKTVQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLS RQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLT-TLPEASDVASITL ALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVV SQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQV FEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNA PRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIII MDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREA IRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLD EFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVC DGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALG GEFKLYLPQLIPHMLRVFMHDNSQGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDA PEVPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQL GKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSSQGDA LASGPVETGPMKKLHVSTINLQK-------------AWGAARRVSKDDWLEWLRRLSLEL LKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIA EVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPA ILESLISINNKLQQPEAASGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNK EDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEE YTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMV SCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMR TWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTAHPQVTYAYMKNMWKSARKI DAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPK VLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTA ATTAASAAA--ATSTEGSNSESEAESNENSPTPSPLQKKVTEDLSKTLLLYTVPAVQGFF RSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTP RPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQA MMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETS FNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPK LLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGH EDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHAL IRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPS SEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTRE KFPEKIPFRLTRMLTNAMEVTGLDGNYRTTCHTVMEVLREHKDSVMAVLEAFVYDPLLNW RLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKAGTTVPESIHSFIGDGLVK PEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGW---- ------------------C-----------------------PFW--------------- ND1 >H sapiens ----MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLF TKEPLKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSI LWSGWASNSNYALIGALRAVAQTISYEITLAIILLSTLLMSGSFNLSTLITTQEHLWLLL PSWPLAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNT LTTTIFLGTTYDALSPELYTTYFVTKTLLLTSL-F--LWIRTAYPRFRYDQLMHLLWKNF LPLTLALLMWYVSMPITISSIPPQT- >M_brandtii ----MYFINLLAMIIPVLLAVAFLTLLERKVLGYMQLRKGPNIVGPYGLLQPIADAVKLF TKEPLQPLTSSLVLFIIAPTLALTLALMMWVPLPMPHPLINMNLSMLFMLALSSLAVYAI LWSGWASNSKYALIGALRAVAQTISYEVTLAIIILSILPMNGSFTLTTLITTQEYMWLMI PSWPLAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAGGPFALFFLAEYANIIMMNA LTIILFLGAYHSPMFSELYTINFATKALLFTMF-F--LWIRASYPRFRYDQLMHLLWKNF LPLTLVMCMWHVTLPIILASIPPQT- >H glaber ----MHIINTLLLLVPILLAMAYLTLMERKLLGYMQLRKGPNIVGPYGILQPIADALKLF IKEPLKPSASSISLFIIAPMLALTLALSMWIPLPMPHPLINMNLGILFILATSSLAVYSI LWSGWASNSKYALLGALRAVAQTISYEVSLAIILLSVLLLSGSFTLGTLMETQKYTWLIL PTWPLAMMWFISTLAETNRAPFDLAEGESELVSGFNVEYAAGPFALFFMAEYINIIMMNA LTTIIFINTSPMSTNPENFTMYFTIKTLMLTSL-F--LWIRASYPRFRYDQLMHLLWKNF LPMSLAMCMWHISFPIGLFGTPPQTT >S franciscanus MVYIFRILELVSFLVPVLLAVAFLTLVERKVLGYMQFRKGPKVVGPYGLLQPFADGLKLF IKETLKPSTASPYLFFLSPLLFLALA----KFMPVHTPTLDLQLSLLLVLGLSRLSVYAI LGSG-ASKSKYSLLGAIRAVAQTISYEIRLALILLSLILFSRRFNLTYIMNVQEFSFSL- PCLPLFYI-FVSTLAETNRAPFDLTEGESEIVSGYNVEYAGGPFALFFIAEYAKIILMNL FSVVLFLGGP--SPFKKLFPIRVIVIGIKTTCLVL--LLVRAAYPRFRYDQLMFLT-KRY LPLSIGALCAILAL-VTLLGIS---- >S purpuratus MVYVFSILELISFLIPILLSVAFLTLVERKVLGYMQFRNGPNVVGPFGLLQPFADGMKVF IKEELKPVNSSPYLFFFSPLLFLALALLLWNFMPVHTPTLDLQLSLLLVLGLSSLSVYAI LGSGWASNSKYSLLGAIRAVAQTISYEISLALILLSLIIFSSSFNLTYIMNTQEFSWFSL SCLPLFYIWFVSTLAETNRAPFDLTEGESEIVSGYNVEYAGGPFVLFFIAEYANIILMNY FSVVLFLGGP--SPLNNLFPISIIIVGIKTTFL-FSVLWVRAAYPRFRYDQLMFLTWKSY LPLSIGALCAILAL-VALLGISLPLF >L variegatus MVYIFRLLELISFLVPVLLAVAFLTLVERKVLGYMQFRKGPKVVGPYGLLQPFADGLKLF IKETLKPSTASPYLFFFSPLLFL-------------------QLSLLLVLGLSRLSVYAI LGSGRASKSKYSLLGAIRAVAQTISYEI-----------FTRRFNLTYIMNVQEFSFSL- PCLPLFYI-FVSTLAETNRAPFDLTEGESEIVSGYKVEYAGGPFALFFIAEYAKIILMNL FSVVLFLGGP--SPFKSLFPIKVIVIGAKTTLLVF--LFVRAAYPRFRYDQLMFLT-KSY LPLAIGALCVTIRL-VVVFGIYL--- >M musculus ----MFFINILTLLVPILIAMAFLTLVERKILGYMQLRKGPNVVGPYGILQPFADAMKLF MKEPMRPLTTSMSLFIIAPTLSLTLALSLWVPLPMPHPLINLNLGILFILATSSLSVYSI LWSGWASNSKYSLFGALRAVAQTISYEVTMAIILLSVLLMSGSYSLQTLITTQEHMWLLL PAWPMAMMWFISTLAETNRAPFDLTEGESELVSGFNVEYAAGPFALFFMAEYTNIILMNA LTTIIFLGPLYYINLPELYSTNFMMETLLLSST-F--LWIRASYPRFRYDQLMHLLWKNF LPLTLALCMWHISLPIFTAGVPPYM- ND2 >L variegatus ---------------GTVIVISTEK-FII-VGLELRTLALVQVLCSNFSPRKVEATIKYF LVQA------LKGALIQAWLTGS-SVLEPLKKVSAICLRVALAFKLGLAPCHFWFPDVLQ GLPFFQGLIIAT-QKIAPLLILFFFGQLVISYLLIVARLISILVGG-GGLNQTQVRKILA FSSIGNMGWLIITSAYSVKAAILMLIIYLVIKTAIFLLFDFLKISTLGHLKTASQLSPTR IALVILLMLSLGGLPPL-------------ISNGFIAFSSIMIVGSLLSLFFYLRISFKT GLILFP-QHIIRITS-RKNAILSPLTTKV------------------------ >M musculus MNPITLAIIYFTIFLGPMITMSSTNLMLMWVGLEFSLLAIIPMLINKKNPRSTEAATKYF VTQATASMIILLAIVLNYKQLGTWMFQQQTNSLILNMTLMALSMKLGLAPFHFWLPEVTQ GIPLHMGLILLTWQKIAPLSILIQIYPLLNSTIILMLAITSIFMGAWGGLNQTQMRKIMA YSSIAHMGWMLAILPYNPSLTLLNLMIYIILTVPMFMALMLNSSMTINSISLLWNKTPAM LTMISLMLLSLGGLPPLTGFLPKWIIITELMKNNCLIMATLMAMMALLNLFFYTRLIYST SLTMFPTNNNSKMMTHQTKTKPNPMFSTL------AIMSTMTLPLAPQLII-- >S purpuratus MRQIVSTFLFVTVVSGTIIVVSSENWFIIWVGLELSTLALVPILCSGFSPRNVEADNKYF LVQASSAALLLNGALGQAWLTGSWSILDPVNEVTSICLSIALAFKIGLAPVHFWFPDVLQ GLPFFQGLIIATWQKIAPLILMFYFSQLGFSYLLITPSLISVLIGGWGGLNQTQVRKILA FSSIGNMGWLVITSAYSFNAAIIMLVIYLIINTSLFLLFDHLKVSTLGHLNTISQLSPIS VALVLLVMLSLGGLPPLTGFILKFTSLYFLVANNFIILSSIMIIGNLQDYFFYLRISFNT SLFLFP-QHIISSASWRNSTIISPLAPKAWLSSVSTVLSTLAIPLTLPLYIIT >S franciscanus MHRIVSTFLFITVVSGTIIVISSKKLFVI-VGLELSTLALVPILCSRFSPRKVEATIKYF ------------------ALTGSWSILTPVKKVTSICLSIALAFKIGLAPCHF-FPDVLQ GLPFFQGLIIAT-QKIAPLVLLFYFRQLVFSYLLIAARLLSILIGG-GGLNQTQVRKILA FSSIGNMG-LVVTSAYSLNAAIVMLVIYLTINTSLFLLFDHLGVSTLGHLKTTSQLSPIR VALVLLVMLSLGGLPPLTGFILKFTSLYFLIANNFIILASIMIVGRLLRLFFYLRISFKT RLILFP-QHIISIAS-RNRAIVSPLTPKT-LISVSAVLSTLAIPLTLPLYIIT >H glaber MNLISNSVIYLTLISGTLITLTSSHWLLMWAGLEMSMFAMIPILTHKTSPRSTEAATKYF LVQATASMMFMMAIIYSVALSGQWAIMHSQNQTISSILMLSLMMKLGLAPFHLWVPEVTQ GANLWSGMILLTWQKIAPLSIMYQTYSSANQTMIISFSLLSILLGGWGGLNQTQLRKILA YSSISHMGWMTTVMCFNPSIMHLNLLIYIMLTLSMFSMLSINTNTTTLSLSHLWNISPIL ANTILIILLSLGGLPPLTGFMPKWMIITEMTKNQSIILPTLMAMMALLNLFFYMRLAYST SLTLFPSTNNLKMKWYTQNTKMPYLLPPL------IIVSTLMLPLSPMMTTLE >H sapiens MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYF LTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQ GTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILA YSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYST SITLLPMSNNVKMKWQFEHTKPTPFLPTL------IALTTLLLPISPFMLMIL >SIG ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------+------------------------ ----------------------------------------------------------+- ------------------------------------------------------------ ND3 >H sapiens -MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVA ITFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSLAYEWLQKGLDWTE >H_glaber -MNMTISLLMNFSLASILMLIAFWLPQMDAYAEKLSPYECGFDPMGSARLPFSMKFFLIA ITFLLFDLEIALLLPLPWASQTNNLTLMLTVSLMLISVLALGLFYEWSQKGLEWDK >S franciscanus MTTIIFLFGITIAVATVFGLAAHALPRRAGDKEKNSPYECGFDPLNSARLPFSFRFFLVA ILFLLFDLEIALLFPLPAAELITNPSTLIPISLIFMIILALGLVFE-VKGGLE-AE >S_purpuratus MTTIIFLFSITIAVAVVLGLAAHALPNRTSDSEKSSPYECGFDPLNSARLPFSFRFFLVA ILFLLFDLEIALLFPLPAASLITPPSTLIPISMVFMVILTLGLVFEWINGGLEWAE >L variegatus MTPIIFIFLITIVVAIVFAAAAHILPKRSKDREKTSPYECGFDPLNSARLPFSFRFFLVA ILFLLFDLEIALLFPLPAAKSSTPPSILIPISLIFMIILALGLVFEWIKGGLE--- >M musculus -MNLYTVIFINILLSLTLILVAFWLPQMNLYSEKANPYECGFDPTSSARLPFSMKFFLVA ITFLLFDLEIALLLPLPWAIQTIKTSTMMIMAFILVTILSLGLAYEWTQKGLEWTE >SIG ------------+--+-------------------------------------------- ND4 >S_purpuratus MITLILFTVGMATTTLLIPSNKLWAGAIFQSALLSLLSLIVLNNHWTASWHNLSSILASD TISAPLIILSCWLAPIALIASKGQLNNSSDLGSRVFIIMIIVITGALIITFSSLELILFY IVVETTLIPTLILITRWGAQMERCQAGLYFMFYTLFGSLPLLIAIIAIYISSSSLSIPNV NLLWANDGSIESLTMWWALSINCFFNNLPVYGFHLWLPKAHVEAPVAGSMILAAILLKIG GYGLMRLIALFSTISMNALSLALIVFCTWGALITSVICVRQTDLKALIAYSSVGHMSIVA AAIFSETSWGMNGALMLMVAHGLVSSALFSLANTVYERSGTRTLAITRGLKLLLPLSTLW WLLMCAANLGLPPSPNLIGEILILSSLISWSVWLFPIVGFAQVFGAIYSLMIFQLSQQGT PFTSIINVFSSFSREHLFAALHILPLILIMINPFSALIAWLK >L variegatus MITLILFTTGIAITNFLVPRNKVWVSSIAQRAALSLLSLIVLTNHWT-SSHKLSSTLASD TISAPLIILRCWLCPIALIARKGHLKKARSLNQRMFISLVIIITGALIITFSSLELLLFY VAFETTLIPTLILITRWGAQMERFQAGLYFMFYTLFGSLPL------------------V ELIWT-EKSINSLTM--ALSIIAFLIKMPIYGFHL-LPKAHVEAPVAGSMILAAILLKLG GYGLTRLISLFSTISLKYLSLVLIVFCS-GALVTRIICIRQTDLKALIAYSSVGHMRVVA AAIFSGTKWGLKGALMLMIAHGLVSSALFSMAKTVYERRGTRTLAITRGLKMLLPLRTLW WLLMCAAKLGLPPSPNLIGEILILSSLIAWSVWLFPILGFATVFGAIYSLMIFQMSNQGT PSRKVAKIAPSFSREHLLARLHILPLVLIIINPMSTLISLK- >S franciscanus ----ILFTVGIATTTFLVPGNKLWARAIFQTALLSLLSLIVLKNHWT-SSHKLSTILASD TISAPLIILRC-LAPIALIARKGHLKTARDLNQRVFITMVIIITGALIVTFSSLELLLFY IAFETTL----------------------------------------------------- -----TERSVESLTI--SLSIIAFLIKMPVYGFHLWLPKAHVEAPVAGSMILAAILLKLG GYGLMRLISLFSTISMKALSLALIVFCS-GALVTSIICVRQTDLKALIAYSSVGHMRIVA AAIFSETKWGMKGALMLMVAHGLVSSALFSLAKTVYERRGTRTLAITRGLKLLLPLRTFW -----------------------------ISSILFPIVGFATVFGAVYSLMIFQLSQQGT PSTGIMKIPPSFSREHLLAALHILPLILI------------- >M musculus MLKIILPSLMLLPLTWLSSPKKTWTNVTSYSFLISLTSLTLLWQTDE-NYKNFSNMFSSD PLSTPLIILTAWLLPLMLMASQNHLKKDNNVLQKLYISMLISLQILLIMTFSATELIMFY ILFEATLIPTLIIITRWGNQTERLNAGIYFLFYTLIGSIPLLIALILIQKHVGTLNLMIL SFTTHTLDTSWSNNLLWLACMMAFLIKMPLYGVHLWLPKAHVEAPIAGSMILAAILLKLG SYGMIRISIILDPLT-KYMAYPFILLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVI ASIMIQTPWSFMGATMLMIAHGLTSSLLFCLANSNYERIHSRTMIMARGLQMVFPLMATW WLMASLANLALPPSINLMGELFITMSLFSWSNFTIILMGLNIIITGMYSMYMIITTQRGK LTNHMINLQPSHTRELTLMALHMIPLILLTASP-KLITGLTM >H sapiens MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQINN-NLFSCSPTFSSD PLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISLQISLIMTFTATELIMFY IFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPLLIALIYTHNTLGSLNILLL TLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLG GYGMMRLTLILNPLT-KHMAYPFLVLSLWGMIMTSSICLRQTDLKSLIAYSSISHMALVV TAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFW WLLASLANLALPPTINLLGELSVLVTTFSWSNITLLLTGLNMLVTALYSLYMFTTTQWGS LTHHINNMKPSFTRENTLMFMHLSPILLLSLNP-DIITGFSS >H_glaber MLKIILPTIMLIPVTWLSKNSLLWINTSCHSLLIALISLPTLNKLDI-NSHNFSTNFFSD SLSSPLVNLTVWLLPLMIIASQHHMKNEPAVRKKLYLSLLITLQALLIMTFTTSEMMMFY ILFEATLIPTLIIITRWGNQAERMKAGLYFLFYTLTGSLPLLVALTYLKNYLGSLNFMLF SYKASPLLPTWSNSMLWLACIMAFMVKFPLYGLHLWLPKAHVEAPIAGSMVLAAILLKLG GYGMMRISQLLEPLT-TSMSYPFILLSLWGMVMTSSICLRQTDLKSLIAYSSISHMALVI TAILIQTPWSYMGATTLMIAHGLTSSLLFCLANSNYERTHSRTMILARGLQTILPLMALW WLLASFTNLALPPSINLVGELLIITSTFSWSNFTIILTGMNVLITALYTLYMLISTQRGT PPHHIINLPPSFTRENTLMTLHLLPLLLMTLNP-KIIMGNLF ND4L >H sapiens -MTPMRKTNPLMKLINHSFIDLPTPFNISAWWNFGSLLGACLILQITTGLFLAMHYSPDA STAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIIL LLATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFF TFHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSL MTLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSIL ILAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYF TTILILMPTISLIENKMLKWA >M_brandtii -MTNIRKSHPLMKIINSSFIDLPAPSNISSWWNFGSLLGICLALQILTGLFLAMHYTSDT TTAFNSVTHICRDVNYGWVLRYLHANGASMFFICLYLHVGRGLYYGSYMYTETWNIGVIL LFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVEWIWGGFSVDKATLTRFF AFHFLLPFIIAAMVMVHLLFLHETGSNNPTGIPSNADMIPFHPYYTIKDILGLLLMITVL LMLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSIL ILIIIPLLHTSKQRSMTFRPLSQCLFWLLTADLFTLTWIGGQPVEHPYVIIGQLASILYF SIIIILMPLISLMENHLLKW- >H_glaber -MTNIRKSHPLIKIINHSFIDLPTPSSISYWWNFGSLLGACLILQIITGLFLSMHYTADT ATAFSSVAHICRDVNYGWLIRYLHANGASMFFICLYLHVGRGMYYGSYMFMETWNIGIIL LLSVMATAFMGYVLPWGQMSFWGATVITNLFSAIPYIGPTLVEWIWGGFAVDKATLTRFF AFHFILPFIITALTMVHLLFLHETGSNNPSGINSDSDKIPFHPYYSFKDFMGLQIMLLIL LTLTLFHPDLLGDPDNYTPANPMSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVMSIL ILVALPLLHTSKQRSMMFRPISQCLFWTFISTLLTLTWIGSQPVEYPYIIIGQLASILYF LIILVLMPLAGLVENKMMK-- >S franciscanus MAAPLRKEHPIFRILKSTFVDLPLPSNLSI-WNFGSLLGLCLIVQILTGIFLAMHYTADI TLAFSSVRHICRDVKYGWLLRKVHAKGASLFFICMYCHIGRGLYYGSYKKIET-KVGVIL FLVTILTAFMGYVLV-GQMSF-AATVITNLVSAIPYMGTTIVQ----------------- -LHFLFPFIIAALAIIHLVFLHNRGANNPVGLKSNYDKAPFHIYYTTKDTVGFILLIAAL FSLALLFPGALKDPENFIPANPLVTPPHIQPE-YFLFAYAILRSIPNKLGGVIALVAAIL VLFLMPLLNTSKKESNSFRPLSQAAF-LLVATFLILT-IGRQPVEYPYVLLGQVASVIYF SLFIFGFPLVSSIENKIIFS- >S_purpuratus MAAPLRKEHPIFRILNSTFVDLPLPSNLSIWWNSGSLLGLCLVVQILTGIFLAMHYTADI TLAFSSVMHILRDVNYGWFLRYVHANGVSLFFICMYCHIGRGLYYGSYNKIETWNVGVIL FLVTILTAFMGYVLVWGQMSFWAATVITNLVSAIPYIGTIIVQWLWGGFSVDNATLTRFF PFHFLFPFIIAALAVIHLVFLHNSGANNPFAFNSNYDKAPFHIYFTTKDTVGFILLVAAL FSLALLFPGALNDPENFIPANPLVTPPHIQPEWYFLFAYAILRSIPNKLGGVIALVAAIL VLFLMPLLNTSKNESNSFRPLSQAAFWLLVAHLFILTWIGSQPVEYPYVLLGQVASVLYF SLFIFGFPIVSSIENKIIFS- >L variegatus MAAPIRKEHPIFRILKGTFVDLPLPSNLSI-WKFGSLLGLCLIVQILTGLFLAMHYTADI TLAFSSVRHICRDVNYG-LLRKVHAKGASLFFICMYCHIGRGLYYGSYKKVET-NIGVIL FLVTILTAFMGYVLV-GQMSFWAATVITNLVSAIPYIGTTIVQ--LGGFSVDKATLTRFF AFHFLFPFIIAALAVIHLVFLHKRGANNPVGLKRNYDKAPFHIYYTTKDTVGFILLITAL FSLALLFPGALKDPENFIPANPLVTPPHIQPE-YFLFAYAILRSIPNKLGGVIALVAAIL VLFLMPLLNTSKKESNSFRPLSQAAF-LLVATFFILT-IGAQPVEYPYVFLGQVASVLYF SLFIFGFPLVSSLEKKIIFS- >M musculus -MTNMRKTHPLFKIINHSFIDLPTPSNISSWWNFGSLLGICLMVQIITGLFLAMHYTSDT MTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGLYYGSYTFMETWNIGVLL LFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFF AFHFILPFIIAALAIVHLLFLHETGSNNPTGLNSNADKIPFHPYYTIKDILGILIMFLIL MTLVLFFPDMLGDPDNYMPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSIL ILALMPFLHTSKQRSLMFRPITQILYWILVANLLILTWIGGQPVEHPFIIIGQLASISYF SIILILMPISGIIEDKMLKLY ND5 >H sapiens MTMHTTMTTLTLTSLIPPILTTLVNP--------------------------------NK KNSYPHYVKSIVASTFIISLFPTTMFMCLDQEVIISNWHWATTQTTQLSLSFKLDYFSMM FIPVALFVTWSIMEFSLWYMNSDPNINQFFKYLLIFLITMLILVTANNLFQLFIGWEGVG IMSFLLISWWYARADANTAAIQAILYNRIGDIGFILALAWFILHSNSWDPQQMALLNANP -SLTP--LLGLLLAAAGKSAQLGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLIRFHP LAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKKIVAFSTSSQLGLMMVTIGINQPHLA FLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMGGLLKTMPLTSTSLTIGSLALAGMPF LTGFYSKDHIIETANMSYTNAWALSITLIATSLTSAYSTRMILLTLTGQPRFPTLTNINE NNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQTTIPLYLKLTALAVTFLGLLTALDLN YLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYLGLLTSQNLPLLLLDLTWLEKLLPKT ISQHQISTSIIT-STQKGMIKLYFLSFFFPLVLTLLLIT---- >H_glaber MNLYISSFIMSLLLLTTPIPLSSINF--------------------------------PK NTSYPSYVKSIISLSFFISLIPTTMLLLSNQEAVISNWNWMHIQTVSINMSFKLDYFSVM FMSVALFVTWSIMEFSMWYMHSDPDMNKFIKYLLLFLITMMILVTANNAMQLFIGWEGVG IMSFLLIGWWLGRSDANTAALQAILYNRIGDIGFIISMVWFMTNLSSWEMQQLLIMQDEM -NYIP--LLGLLLAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLMIRFYP LIQHNQTILTMSMCLGATTTLFTALCALTQNDIKKIIAFSTSSQLGLMMVTIGINQPHLA FLHICMHAFFKAMLFMCAGSIIHNLNNEQDIRKMGGLLKMLPFTSSSLIIGSLALTGMPF LTGFYSKDLIIESANSSYINAWALLITLISTSLTAVYSSRIVFYALLDHPRSTTTLNINE NNPLLINPIKRLAMGSILAGFIISNNIPPTSIPQMTMPTHIKLSTLMVTALGFMTAMELI IMSHYLKNKYPNKLFNFSNMLGYFTPTAHRFMPYKKLMMSQNLASSSMDAIWLEKSAPKN VSDIQYTASMFT-SNQTGLIKLYFLSFLLSFMVALILST---- >S franciscanus ------------------------------------------------------------ -------------------------INTEFSDINITLSLWLNNTPTNISLNFIYDQYFLV FLSIALIVTWSIMEFSFYYMAEDPNSSAFFRLLTIFLLNMLILTCSNSLFLVFLGWEGVG FLSFLLISWWTTRNDASSSALEAVIYNRIGDIGLITFMALSALSFNSWNLTEILSSSEDL TPFLPFLLFGLVLAAAGKSAQFGLHPWLPAAMEGPTPVSALLHS---------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------- >S_purpuratus MVISPSLIISSLNLGILTILLGSIFFFSKSYFSKGNVNFPLIKTTSACLSVNNDKEETIE YNSGPFAMAILKVLAFLSVLSLLVTCNNSIQSINITLSLWLSNTPLNISLNFIYDQYFLV FLSVALIVTWSIMEFSFYYMTEDPNSSAFFRLLTIFLLNMLILTCSNSLFLIFLGWEGGG FLSFLLISWWTTRNDASSSALEAVITNRIGNIGLITFMALSALNFNSSNLTNILSSNENL TPLLPFLLFGLILAAAGKSAQFGLHPWLPALLEGPTPVSALLHSSTMVVAGVFLLVRTSE LFSSPLITHSLVLILGGTTALFAASTAIAQHDIKKIIAYSTTSQLGLMVTAIGIGQPALA FFHICTHAFFKAMLFLCSGSVIHSLSDEQDLRKMGGLSKLLPVTSSCLILGSLALMA-PL LAGFYSKDLILEATSASVLNLLGIVLSIVATMLTAVYSFRIIFFCFSLSPSCSSPFSHSE ENFNLNNALLRLATGTIASGWFFSNLL--FAPPSFNVTSLAKGTPLIVPIIG--VAALFM SLISSTSNSIGSNAHSATTSQWFFVDAVHLSIITMSLALS-FFSSRTLDRGWQENIGPQG IAPTSTALSKISQAGQIGLIKRYILSSMASVLVILALSLLILS >S franciscanus ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------EGVG FLSFLLIS-WTTRKDARSSELEAVIYKRIGDIGLITFMALSA------------------ -------LFGLVLAAAGKSAQFGLHPWLPAAMEGPTPVSALLHRSTMVVAGVFLLVRTRD LFSLSPNAQSIVLILGGTTALFAASTAIAQHDIKKIIAYSTTRQLGLMVTAIGIGQPILA FFHICTHAFFKAMLFLCSGRVIHRLRDEQDLRKMGGLRKLLPVTSACLILGRLALMGTP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------- >L variegatus ------------------------------------------------------------ ---------------------------------------LLAKTPTKISLNFIYDQYFLL FLTVALIVT-SIMEFSFYYMADDPKGTSFFRLLTIFLLKMLLLTCSKRLFLIFLG-EGVG FLSFLLIR-WTTRKDARRSALEAVIYNRIGDIGLITFMALSILTLNS-NLTEI------- -SFLPFLLFGLILAAAGKSAQFGLHP-LPAAMEGPTPVSALLHRSTMVVAGVFLLVRTRD LFVLSPRTQSVVLILGGITALFAASTAIAQHDIKKIIAYSTTRQLGLMVSSIGIGQPILA FFHICTHAFFKAMLFLCSGRIIHRLSDEQDLRKMGGLRKLLPVTSACLALGRLAL---PF LAGFYSKDLILEAARASFLNTRGLSLSIVATMLTAVYRFRIVYFCT-------------- ------------------------------------------------------------ -----------------------------------SFISSLFLSSRTLDRG-QEEIGPQG IAQSSTFLSKANQRRQIGLIKRYILSSIISI------------ >M musculus MNIFTTSILLIFVLLLSPILISMSNL--------------------------------IK YINFPLYTTTSIKFSFIISLLPLLMFFYNNMEYMITTWHWVTMNSMELKMSFKTDFFSIL FTSVALFVTWSIMQFSSWYMHSDPNINRFIKYLTLFLITMLILTSANNMFQLFIGWEGVG IMSFLLIGWWYGRTDANTAALQAILYNRIGDIGFILAMVWFSLNMNSWELQQIMFSNNND -NLIP--LMGLLIAATGKSAQFGLHPWLPSAMEGPTPVSALLHSSTMVVAGIFLLVRFHP LTTNNNLILTTMLCLGALTTLFAAICALTQNDIKKIIAFSTSSQLGLMMVTLGMNQPHLA FLHICTHAFFKAMLFMCSGSIIHSLADEQDIRKMGNITKTMPFTSSCLVIGSLALTGMPF LTGFYSKDLIIEAINTCNTNAWALLITLIATSMTAMYSMRIIYFVTMTKPRFPPLISINE NDPDLMNPIKRLAFGSIFAGFVISYNIPPTNIPILTMPWFLKTTALIISVLGFLIALELN NLTMKLSMSKPNPYSSFSTLLGFFPSIIHRITPMKSLNLSLKTSLTLLDLIWLEKTIPKS TSTLHTNMTTLT-TNQKGLIKLYFMSFLINIILIIILYSINLE >SIG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------+------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ p66Shc >H sapiens MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS FFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIDGAAMPESGPLPLLQDMNKLSGGGGR RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMG-PGVSYLVRYMGCVEVLQSMRAL DFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRS-NLKFAGMPITLTVST SSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQ DVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEP PLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGATLPVGQPVGGDPEVRKQMPPPPPCPG RELFDDPSYVNVQNLDKARQAVGGAGPPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVS MAEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDP EGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL >H glaber MDLLPPKPKYNPLRNESLSSLEEGASGSSPPEELPSPSASSLGPILPPLPSDDSPTTLCS FFPRMSNLKLANPAGGRLGPKGEPGRAAEDGEGITGTAVLDSGPLPLLQDMNKLSGGSGR RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMG-PGVSYLVRYMGCVEVLQSMRAL DFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSVLGRS-NLKFAGMPITLTVST SSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQ DVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPSDHQYYNDFPGKEP PLGGVVDMRLREGATPGAARPTPPSAQTPSHLGATLPVGQPIAGDPEVRKQMPPPPPCPG RELFDDPSYVNVQNLDKARQAGGGAGPPNPAVNGSAPRDLFDMKPFEDALRVPPPPQLMS MAEQLRGEPWFHGKQSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDP EGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL >M brandtii MDLLPPKPKYNPLRNESLSSLEEGASGSSPPEELPSPSASSLGPILPPQAGDDSPTTLCS FFPRMSNLKLANPAGARPGPKGEPGRVAEDGEGTAGAAVPDSGPLPLLQDMNKLSGGGGR RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMG-PGVSYLVRYMGCVEVLQSMRAL DFNTRTQVTREAISLVCEAVPGAKGASRRRKPCSRPLSSILGRS-NLKFAGMPITLTVST SSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQ DVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEP PLGGVVDMRLREGAPQGPARPTLPSAQSPSHLGATLPVGQPAGGDPEVHKQMPPLPHCPG RELFDDPSYVNIQNLDKARQAGGGAGPPNLAVNGSAPRDLFDMKPFEDALRVPPPPQSVA MAEQLRGEPWFHGKLNRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDP EGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVERKL >S franciscanus ------------------------------------------------------------ ------------------------------------------------------------ -------------------FCLL----FLS------------------------------ ------------------------------------------------------------ -----------------------------------------------ACHVLECLAGLAQ DVITTVGQAFEIRFKDYLRNPPQVFSTPDR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------- >S purpuratus ------------------------------------------------------------ ------------------------------MAGVMSHFKKNKGP---------------- --NMVGQRSNEELWTRTGTFINKPTRGWLHIEEELKDHGGVCYGVRYVGCVEVKQSMRTL PFEMRGQVTKEAIFRICDA---AGFKYTRKKKASKTICKIIGENPNILFGGANVNLTIST ASINIRIKETGKPIANHQMQGISFASGGDAN----------------ACHVLECLAGLAQ DVITTVGQAFEIRFKDYLRNPPQVFSTPDR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------- >L variegatus LQMMHNTSLFNEIM---------------------------------------------- ------------------------------------------------------------ --RIHASAYYINHWSFEKAVCNE----FLPCLELLYGYSFIDIWIYLHSYLTLTPIFYIV QQRIRCKHPH-------------KYGIKLHEQASKTICKIVGENPNILFGGANVNLTIST ASINIRIKETGKV-----KPSIIYFCCNSSSRIDC------------ACHVLECLAGLAQ DVITTVGQAFEIRFKDYLRNPPQVFSTPDR------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------- >M musculus MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGPILPPLPGDDSPTTLCS FFPRMSNLKLANPAGGRLGPKGEPGKAAEDGEGSAGAALRDSGLLPLLQDMNKLSGGGGR RTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMG-PGVSYLVRYMGCVEVLQSMRAL DFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSSILGRS-NLKFAGMPITLTVST SSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQ DVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEEPPDHQYYNDFPGKEP PLGGVVDMRLREGA----ARPTLPSAQMSSHLGATLPIGQHAAGDHEVRKQMLPPPPCPG RELFDDPSYVNIQNLDKARQAGGGAGPPNPSLNGSAPRDLFDMKPFEDALRVPPPPQSMS MAEQLQGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDP EGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVDRKV PDK1 >H sapiens ------------------------------------------------------------ MARTTSQLYDAVPIQ-------SSVVLCSCPSPSMVRT-QTESSTPPGIP-GGSRQGPAM DGTAAEPRPGAGSL-QH-AQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYA IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK YIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKV LSPESK---QARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGN EYLIFQKIIKLEYD---FPEKFFPKARDLVEKLLV-----LDATKRLGCEEMEGYGPLKA HPFFESVTWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLS ASDTGLPQRSGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLIL KMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKN-------- ------FKTF--FVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ >H_glaber ------------------------------------------------------------ MARTTSQLYDTVPIQ-------PSVVLCACPSPSMVRT-QTESGTAPSVPSGGSRQGPTM DGTTAESRPSANPL-QHAAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYA IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFIKLYFTFQDDEKLYFGLSYAKNGELLK YIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKV LSPESK---QARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGN EYLIFQKIIKLEYD---FPEKFFPKARDLVEKLLV-----LDATKRLGCEEMKGYEPLKA HPFFESITWKNLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLS VVDASLPHRSDSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLIL KMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKN-------- ------FKTF--FVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ >M_brandtii MRFYPSMNPANHRSTPGAEGKQSTAGPLQMVEGGLVGLCGAAAEWSQKNLDPECTWHGGQ KAEAPRRQYDTIPIQ-------SSVVLCSCPSPSMVRT-QTDSGSAP-VPSGGSRQGPTM DSTAAESRPSANSL-QHAAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYA IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK YIRKIGSFDETCTRFYTAEMVSALEYLHGRGIIHRDLKPENILLNEDMHIQITDFGTAKV LSPETK---QARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGN EYLIFQKIIKLEYD---FPEKFFPKARDLVEKLLV-----LDATKRLGCEEMEGYGPLKA HSFFDSITWENLHHQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGCMQVSSSSSSHSLS ASDTGLPQRAGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQASGNPWHQFVENNLIL KMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKN-------- ------FKTF--FVHTPNRTYYLMDPSGNAHKWCKKIQEVWRHRYQSHPDTTVQ >S franciscanus ----------------------------------------------------------RH KERYEPRVKTYNPQAYKFYMEQHVENILKSHRQRITRRMQLEQEMQRVDLTSGDRDQMRR MLFQKESNYLRLKR-----------AKMNKSMFKKIKTLGIGAFGQVAIAQKRDTKAMYA MKYMRKAMCIQKDQARHVKAEQEILAAAEHPWLVKLYYSFQDSDKLCFVMEYVNGGDLFY HLSREGVFDEERTRFYTAEIVEALAYLHTHGIVYRDLKPENILLDNKGHVKIADFGRAKE FDSLNDIL-IVNIIEFQGTPLYMAPELVEEKPYDHTADLWSLGCILYELFVGTPPFYTNS IFQLVSLIIKVRNTVICFHLVF------MIAFLLV-----IDPSKRLGCDECGGYPALKA HPFLEGVDWENLHEQKAP---VLKPCTVVDGEEIHSEYY--VDDFD-LELNPTSLSEYLK RIETHDRPHSPTRDNKYVVD-----------LTPAERKQRLERQQKENKWHRFVEGNLIL KNGWVDKRK------------PG----YIAPESYPRPGEIGGDDKDPGSHLQDIVAMSMP LDDSHYISCAKRLTVQPNRTYYLIDPESDAVEWCQAIKEMYRHTYQKSI----- >S_purpuratus -----------------------------------------------------------M ASVNSAEFSECKPII-------HSPVSRSCHQEAMSKHKSTDSQPISSSGNSGSSSKASN NQFASSPRSATSPS---PSPSSTSILKKKRADFRFGTILGEGSYSEVVLATEIATGNQYA IKVLEKRHIIREKKEKYVLREKEVLSRLDHPFFVRLYFTFQDNYKLYFGLSLAKRGELLP YIKKLGSFDESSSRFYTSEIILALEYLHSMGIIHRDLKPENILLNEKMHIQITDFGTAKI IGADDKKEGQPRAKSFVGTAQYVSPELLTEKSATKSSDLWALGCIVYQLQAGLPPFRASN EYMIFQKIIKLEYD---FPDGFSQTARDLVSKLLV-----IDPSKRLGCDECGGYPALKA HPFLEGVDWENLHEQKAP---VLKPCTVVDGEEIHSEYY--VDDFD-LELNPTSLSEYLK RIETHDRPHSPTRDNKYVVD-----------LTPAERKQRLERQGKENKWHRFVEGNLIL KNGWVDKRKGLFARRRMLLLTEGPHLYYVDPENMVLKGEIPWSPQLKVEAKN-------- ------FKTY--FVHTPNRTYYLIDPESDAVEWCQAIKEMYRHTYQKSI----- >L variegatus ----------------------------------------------------------KH KMRYEPRYRWYRPPAYIFYMEQHYPIIKS--HRQIARQLQNKQMYQRYDLNCGLCMCKAI MLFFEELFCSGEND-----------LKMNKSMFKKIKTLGIGAFGQVAIAQKRDTKAMYA VKYLRKAHIIRKDQAKYVLAEQEILAALDHPFLVKLYFTFQDKEKLYMVLDYAPGGDLHY YLIQLGSFDEETSRFYAAEIILALEYLHALGIVYRDLKPENILLDEKGHVKISDFGRAKI IGTDDKKDGITQLMS-SGTPLYMAPELVEEKPYDHSADLWALGCILYQLQAGLPPFYASN IYQLVQKIIKLEYD---FPDGFSQTARDLVSKLLVSAILPLDENKR--NQVCILFQIIMA FFNF----FFPIHCQ------IYYLIHIISYKYYYYYYYSTVDDFD-LELNPTSLSEYLK RIETHDRAHSPTRDNKYVVD-----------FTPGERKQRLERQRKENKWHRFVEGNLIL KNGWVDKRKGLFARRRMLLLTEGPHLYYVDPENMVLKGEIPWDKLSRAAYIS-------- ------VSCC----FQPNRTYYLIDPESDAVEWCSAIKEMYRHTYQKSI----- >M musculus ------------------------------------------------------------ MARTTSQLYDAVPIQ-------SSVVLCSCPSPSMVRS-QTEPGSSPGIPSGVSRQGSTM DGTTAEARPSTNPLQQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYA IKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLK YIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKV LSPESK---QARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGN EYLIFQKIIKLEYH---FPEKFFPKARDLVEKLLV-----LDATKRLGCEEMEGYGPLKA HPFFETITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVSSSSSSHSLS TVETSLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLIL KMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKN-------- ------FKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQYQSNPDAAVQ PI3K >H sapiens (alpha) ----------------------MPPRPSS-GELWGIHLMPPRILVECLLPNGMIVT---- ---------LECLREATLITIKHELFKEA----------------------RKYPLHQLL QDESSYIFVSV----------TQEAERE--EFFDETRRLCDLRLFQPFLKVIEPVGNRE- -EKILNREIGFAIGMPVCE---FDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMY VYPPNVESSP--ELPKHIYNKLDKGQIIVVIWVIVS--------------PNNDKQKYTL KINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLE-KYPLS QYKYIRSCIMLGRMPNLMLMAKES----LYS------QLPMDCFTMPSYSRRISTATPYM NGETSTKSLWVINSALRIKILCA----TYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQ RVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKG------------------RKGAK EEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHG----LEDLLNPIGVTGSNPNKE-TP CLELEFDWFSS-VVKFPDMSVIEEHANWSVSREAGFSYSHAG-LSNRLARDNELRENDKE QLKAISTRDPLSEITEQEKD-FLWSHRHYCVT-IPEILPKLLL-SVKWNSRDEVAQMYCL VKDWPPIKPEQAMELLDCNYPDPMVRG----FAVRCLEKYLTDDKLSQYLIQLVQVLKYE QYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNK------TVS-QRFGLLLESYCRAC G-MYLKHLNRQVEAMEKLINLTDILKQEKKDETQ-KVQMKFLVEQMRRPD-FMDALQGFL SPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDML TLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKG-GLKGAL- -QFNSHTLHQWLKDKN-----------------KGEIYD---------AAIDLFTRSCAG YCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIV ISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIR KTLALD-KTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIK------QHALN >H sapiens (gamma) -----------MELENYKQPVVLREDNCRRRRRMKPRSAAASLSSMELIPIEFVLPTSQR KCKSPETALLHVAGHGNVEQMKAQVWLRAL---------------------ETSVAADFY HRLGPHHFLLL-----------YQKKGQWYEIYDKYQVVQTLDCLRYWKATHRSPGQIHL VQRHPPSEESQAFQRQLTALIGYDVTDVSNVHDDELEFTRRGLVTPRMAEVASRDPKLYA MHPWVTSKP--------LPEYLWKKIANNCIF----------------IVIHRSTTSQTI KVSPDDTPGAILQSFFTKMAKKKSLMDIP----ESQSEQDFVLRVCGRDEYLVG-ETPIK NFQWVRHCLKNGEEIHVVLDTPP--DPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDH ESVFTVS-LWDCDRKFRVKIRGIDIPVLPRNTDLT----VFVEANIQHGQQVLCQRRTSP KPFTEEVLWNVWLEFSIKIKDLPKGALLNLQIYC-GKAPALSSKASAESPSSESKGKVQ- ----LLYYVNLLLIDHRFLLRRGEYVLHMWQISGKGEDQGSFNADKL-TSATNPDKENSM SISILLDNYCH-PIALPKHQPTPDPE-------GDRVRA---------EMPN----QLRK QLEAIIATDPLNPLTAEDKE-LLWHFRYESLKH-PKAYPKLFS-SVKWGQQEIVAKTYQL LARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFE PYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQS------RHYQQRFAVILEAYLRGC GTAMLHDFTQQVQVIEMLQKVTLDIKSLSAEKYDVSSQVISQLKQKLENLQNSQLPESFR VPYDPGLKAGALAIEKCKVMASKKKPLWLEFKCADPTA-LSNETIGIIFKHGDDLRQDML ILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGN----T GAFKDEVLNHWLKEKS----------------PTEEKFQ---------AAVERFVYSCAG YCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFV MGTS--GKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIR DALTVG-KNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA- >H glaber -----------MELENSEPPVILREDNLRRRRRMKPRSAASSLSSTELVPIEFVLPTSQR HSKTPETVLLHVAGHGNVEQMKAQVWFRAL---------------------ETSAAADFY HRLGPDHFLLL-----------YQKKGQWYEIYDKYQVVQTLDCLQYWKVLHQSPGQIHL VQRHAPSEETLAFQRQLTALIGYDVTDVSNVHDDELESARRRLVTPRMAEVASRDARLYS MHPWVTSKP--------LPEYLSKKITNNCIF----------------IVIHRSTTSQTI KVSADDTPASILQSFFAKMARKKSLMDIP----ESQSEQDFVLRVCGRDEYLVG-DTPIK NFQWLRHCLKNGEEIHLVLDTPP--DPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDH ESVFTVS-LWDCDRNFRVKIRGIDIPVLPRNADLT----VFVEANIQHGQQVLCQRRTSA KPFTEEVLWNVWLEFSIKIKDLPKGALLNLEIYC-GKAPGQSGKSPAETPGSESRGKAQ- ----LLYYVNLLLIDHRFLLRHGEYVLHMWQIPGKGEDQGSFNADKL-TSATNPDKENSM SISILLDNYCH-PIALPKHQPTPDPE-------GDRVRA---------EMPN----QLRK QLEEIIATDPLNPLTAEDKE-LLWHFRYESLKH-PKAYPKLFS-SVKWGEQETVAKTYQL LARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFE PYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQS------RHYQQRFAVILEAYLRGC GTAMLQDLAQQVHVIEMLQRVTIDIKSLSAEKYDVSAQVISQLKQKLENLQNSNLPKSFR VPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKCADPTA-LSNETIGIIFKHGDDLRQDML ILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGN----T GAFKDEVLNHWLKEKC----------------PIEEKFQ---------AAVERFVYSCAG YCVATFVLGIGDRHNDNIMISETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFV MGTS--GKKTSLHFQKFQDVCVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIR DALTVG-KSEEDSKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA- >M_brandtii ---------------------------------MKPRGSAASLSSMELIPIEFVLPTSQR TSKTPETALLHVAGHGNVEQMKAQVWLRAL---------------------ETSSAADFY QRLSPDHFLLL-----------YQKKGQWYEIYDKYQVVQTLDCLRYWKVLHRSPGQIHV VQRRGPSEETLAFQRQLTALMGYDL-----------EFTRRRLVTPRMAEVAGRDPQLYA MHPWVTSKP--------LPEYLLKKIAHNCIF----------------IVIHRSTTSQTI KVSADDTPAAILQSFFTKMAKKKSLMDIP----ESQSEQDFVLRVCGRDEYLVG-ETPLK NFQWVRHCLKNGEEIHLVLDAPP--DPAQDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDH DSVFTVS-LWDCDRKFRVKIRGIDIPVLPRNADLT----VFVEANIQHGQQVLCQRRTSP KPFTEEVLWNVWLEFSIRIKDLPKGALLNLQIYC-GKAPALSGKASAETTSPEARGKAQ- ----LLYYVNLLLIDHRFLLRHGEYVLHMWQISGKGEDQGSFNADKL-TSATNPDKDSSM SICILLDNYCH-PIALPKHRPTPDPE-------GDRVRA---------EMPN----QLRK QLEAIIATDPLNPLTAEDKE-LLWHFRYESLKH-PKAYPKLFS-SVKWGQQEMVAKTYQL LARREVWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLNYLLQLVQAVKFE PYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQS------RHYQQRFAVILEAYLRGC GTAMLRDFTQQVQVIEMLQKVTIDIKSLSAEKYDVSSQVISQLKQKLENLQNSNLPKSFR VPYDPGLKAGALVVEKCKVMASKKKPLWLEFKCADPTA-LSNETIGIIFKHGDDLRQDML ILQILRIMESIWEIESLDLCLLPYGCISTGDKIGMIQIVKDATTIAKIQQSTVGN----T GAFKDEVLNHWLKEKC----------------PIEEK-----------AAVERFVYSCAG YCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFV MGTS--GKKTSLHFQKFQEVCTKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIR DALTVG-KNEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA- >S franciscanus ----------------------MAPGSVPNLDQWSSHDMHSKIRLECLLPNGIYIP---- ---------MQCSREATLEKIKAELWNKA----------------------KSEPLFNLL LDLNFYIFQCI----------NYSAEQE--ELLDEKRRLCDIKPFQPWLKVVEPAGNRE- -EKMLNYEIGQYCDYILHE---YDLMKNQEVHDFRSNMKRMCMAVQKAHMKWSWDRKAMY LFPPEVDLS--------APNNLPESILINMRF------------------QH--SVSSKL QKPSMEKAEDLVE----KAQKKMSMYQ------QNTQPEEYVLKIRSYENFLLG-GHPLS KYQYIRKAVREGQKPELILIHKS--ELKVED------RFKDPMFNVLAQKEEQAPPLPSK AG-RYVS--WDIEEKVRVTFH------LAKNVNVVEKSGVYLKAGIYHGEEPLCPIVSSK QVPWPDPKWQETYEADIKVSDIPRSAKLCISIYSSEKKKIVKTTSGAQLDQGKTKRRNPR QDLVPIAWVNLTFFDYRSQLRSGPLKLFMWPASED------IDLNPLGHCESNPSRDDTT SIEMSFEQYRQGSVSYPTFDKVIERA-------ADIARSD----DNPFQTPS---EQVLE ELRQIVEKDPLEPLSEQERE-DLWLARQDCRDQLPNALPRLLM-CVHWNHRDEVAQVSQG EKR---------------------------------------GEGKKKAYEVVIKPPHYQ SQYTIALAIMYYQCAPT-----HFIN-NSRSEMHKP------SVS-RRFGLMLEAYCRSL G-PYLKLLVRQVEALDKLSKLTESLNERKAKQQD-KGEIRDMMKKVLQQDSYADTLSNFV SPLSHAIISKFHIIIKVKFMSSKMRPLWLVFENDDPI----GDDVFVLFKNGDDLRQDML TLQVMQIMDNIWQEEGLDLRIIPYKTLATGPKVGLIEVVTNSDTIANIQKQH-GSVNVLT AAFQKAALFEWIKKHS----------------PTDEMLD---------AAIETFTKSCAG YCVATFILGIGDRHSSNIMVIQSLQIFHIDFGHFLGNYKKKYGIKRERVPFVLTHDFLHV ITKGK-DASKSIEFDSFRRCCEEAFMILRRRGNLLINLFAMMLSSGIPEL-SDETIKYLR DVLVLD-RNEDDALRFFQGKFNEALKNSWKTSLDWMMHHI-------AHRD- >S_purpuratus ----------------------MAPGSVPNLDQWSEGDLHANVELMCLLPNGIYIP---- ---------LQCSREATLTNIKRELWTKA----------------------KSEPLFNLL LDLNFYIFQCI----------NYSAEQE--ELLDEKRRLCDIKPFWSTLRVVRKAGDVE- -DRVLNSQIGLCIGKSLHE---YDMMKNQEVHDFRSNMKRMCMSVQKAHMKWPWDKKAMY LFPPEVDLA--------APNNLPENLLINMRF------------------SSSLSTTSVL QVKSMEKAEDLVE----KAQKKMSMYQ------QNTQPEEYVLKIRSYEDFLLG-GHPLS KYKYIRKAVKKGQKPELILIHKS--ELKVED------RFKDPMFNVLAQKEEQAPPLPSK AG-RYVS--WDIEEKVRVTFH------LAKNVNVIEKSGVRLKAGVFHGDEELCPFFTSK EVEGPDPKWQETYEADINVSNLPRMAKLCIMVYTLGNKKIVKTTSGAQLDQGKAKKKFPR KDLVPIAWVNLTFFDYRSQLRSGPHKLFMWPASED------IDLNPLGHCESNPSKDDTT CIEVSFEQYRQGSVSYPTFDKVIERA-------ADIARSD----DNPFETPS---EQALE ELRQIVEKDPLEPLSEQERE-DLWLARQDCRDQLPHALPRLLK-CVHWNHRDEVAQV--- ------------------------------------------NDQLSQYLLQLVQALKYE THLDCAIGKFLLDRALSNQRIGHFLFWHLRAEMHQS------AVC-TRFGLMLEAYCRGS M-AHIKTLSKQVESLNKMKNLNELIKSKQAKQQD-KGEIRDMMQKVLQQDSYADTLSNFV SPLAPSNKLKCLRLNKCKFMSSKMRPLWLVFENDDPI----GDDVYILFKNGDDLRQDML TLQVMQIMDNIWQEEGLDLRIIPYKTLATGPKVGLIEVVTNSDTIANIQKQH-GSVNVLT AAFQKAALFEWLKKHS----------------PTEEMLN---------KAIEDFTFSCAG YCVATYVLGIGDRHNDNIMVKESGQLFHIDFGHFLGNYKRKFGLKRERVPFVLTHDFVHV ITRGK-GASTTTEFDSFRRCCEEAFMILRRRGNLLINLFAMMLSSGIPEL-SDETIKYLR DVLVLD-RSEDDALRFFQGKFNEALKNSWKTSLDWMMHHI-------AHRD- >L variegatus ----------------------MPPVSVPNLDQWSSHEMPSKIRLMCLLPNGIYIP---- ---------MQCSREATLEKIKQMLWRKA----------------------KSYPLAHLL LEASYYIFQCI----------TYSAEQE--ELYDEKRRLCDIKPFQPTLKVVRPAGDRE- -EKMLNYQIG-CIGKSLHE---YDLMKNQEVHDFRSNMKRMCMSVQKAHMKWSWDRKATY LFPPQVDLS--------APNDLPESILIDMRF--------------------FSSWVSLS RGSGFAVAVVLLWLRSPKTGKCAAFAK-------NAHIPQYPIIKQKKGATERS-FHPRK ----IAQAKKKAPHPFIRMRARP---IKVPQKE--CPQIIPPIICIAGHNQVIATYIAAQ ----IIS--CHSCSKCRSLIQ------IISSMQIQ----IYLKAGIYHGDEELCPFFTSK EVEGPDPRWGETYEAEIKVSILPRMAKLCVMVYTLGNKKIVKTTSGAQLDQGKQRRRNPR KDLVPIAWVNLTFFDYRSQLRTGPVKLFMWPASDD------IDLNPLGPCESNPSRDDTT CIELSFEQYRQGSVSYPTFDKVIERA-------ADIARSD----DNPFETPQ---EQALD ELRQIVEKDPLEPLSEQERE-DLWLARQDCRDQLPHALPRLLR-CVHWNHRDEVAQV--- ------------------------------------------RRGFICSCSQIIQVLKYE SYLDNPLARFLLKRSLYNQRIGHFSFPILRAEMHQS------AVC-TRFGLMLEAYCRGS M-AHIKTLSKQVSSLNKMKNLNELIKSKQAKQQD-KGEIRDMMKKVLQQDSYADTLSNFV SPLSPAFFI-FLRLNKCKFMSSKMRPLWLVFENDDPI----GDDVFLLFKNGDDLRQDML TLQVMQIMDNIWQEEGLSLRIIPYRTLATGPKVGLIEVVTNADTIANIQKQH-GSVNVLT AAFQKTALFEWIKKHS----------------PTEERLS---------QAIEDFTLSCAG YCVATYVLGIGDRHNDNIMVTKSGQLFHIDFGHFLGNYKRKFGVKRERVPFVLTHDFVHV ITRGK-GASTTTEFDQVP-CCEEAFMILRRRGNLLINLFAMMLSSGIPEL-SDETIKYLR DVLVLD-RSEDDALRFFQGKFNEALKNSWKTSFDWMMHHI-------ANRD- >M musculus -----------MELENYEQPVVLREDNLRRRRRMKPRSAAGSLSSMELIPIEFVLPTSQR ISKTPETALLHVAGHGNVEQMKAQVWLRAL---------------------ETSVAAEFY HRLGPDQFLLL-----------YQKKGQWYEIYDRYQVVQTLDCLHYWKLMHKSPGQIHV VQRHVPSEETLAFQKQLTSLIGYDVTDISNVHDDELEFTRRRLVTPRMAEVAGRDAKLYA MHPWVTSKP--------LPDYLSKKIANNCIF----------------IVIHRGTTSQTI KVSADDTPGTILQSFFTKMAKKKSLMNIP----ESQSEQDFVLRVCGRDEYLVG-ETPLK NFQWVRQCLKNGDEIHLVLDTPP--DPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDH ESVFTVS-LWDCDRKFRVKIRGIDIPVLPRNTDLT----VFVEANIQHGQQVLCQRRTSP KPFAEEVLWNVWLEFGIKIKDLPKGALLNLQIYC-CKTPSLSSKASAETPGSESKGKAQ- ----LLYYVNLLLIDHRFLLRHGDYVLHMWQISGKAEEQGSFNADKL-TSATNPDKENSM SISILLDNYCH-PIALPKHRPTPDPE-------GDRVRA---------EMPN----QLRK QLEAIIATDPLNPLTAEDKE-LLWHFRYESLKH-PKAYPKLFS-SVKWGQQEIVAKTYQL LARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYLLQLVQAVKFE PYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQS------RHYQQRFAVILEAYLRGC GTAMLQDFTQQVHVIEMLQKVTIDIKSLSAEKYDVSSQVISQLKQKLESLQNSNLPESFR VPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKCADPTV-LSNETIGIIFKHGDDLRQDML ILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAQIQQSTVGN----T GAFKDEVLNHWLKEKC----------------PIEEKFQ---------AAVERFVYSCAG YCVATFVLGIGDRHNDNIMISETGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLFV MGSS--GKKTSPHFQKFQDVCVRAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIR DALTVG-KSEEDAKKYFLDQIEVCRDKGWTVQFNWFLHLVLGIKQGEKHSA- >C elegans MSMGRSPSTTFRSRTGSHGARDLIAGHGRNSRRISQMHVNILHPQLQTMVEQWQMRERPS LETENGKGSLLLENEGVADIITMCPFGEVISVVFPWFLANVRTSLEIKLSDFKHQLFELI APMKWGTYSVKPQ---DYVFRQLNNFGEIEVIFNDDQPLSKLELHGTFPMLFLYQPDGIN RDKELMSDISHCLGYSLDK------LEESLDEELRQFRASLWARTKKTCLTRGLEGTSHY AFPEEQYLCVGESCPKDLESKVKAAKLSYQMFWRKRKAEIN--------GVCEKMMKIQI EFNPNETPKSLLHTFLYEMRKLDVYDT------DDPADEGWFLQLAGRTTFVTNPDVKLT SYDGVRSELESYRCPGFVVRRQS---LVLKDYCRPKPLYEPHYVRAHERKLALDVLSVSI DSTPKQS---KNSDMVMTDFRPTASLKQVSLWDLDAN--LMIRPVNISGFDFPADVDMYV RIEFSVYVGTLTLASKSTTKVNAQFAKWNKEMYTFDLYMKDMPPSAVLSIRVLYGKVKLK SEEFEVGWVNMSLTDWRDELRQGQFLFHLWAPEPT------ANRSRIGENGARIGTNAAV TIEISSYGGRVRMPSQGQYTYLVKHR-------STWTETLN---IMGDDYESCIRDPGYK KLQMLVKKHESGIVLEEDEQRHVWMWRRYIQKQEPDLLIVLSELAFVWTDRENFSELYVM LEKWKPPSVAAALTLLGKRCTDRVIRKFAVEKLN----EQLSPVTFHLFILPLIQALKYE PRAQSEVGMMLLTRALCDYRIGHRLFWLLRAEIARLRDCDLKSEEYRRISLLMEAYLRGN E-EHIKIITRQVDMVDELTRISTLVKG--------MPKDVATMKLRDELRSISHKMENMD SPLDPVYKLGEMIIDKAIVLGSAKRPLMLHWKNKNPKSDLHLPFCAMIFKNGDDLRQDML VLQVLEVMDNIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGT-GFMNTAV RSIDPSFMNKWIRKQCGIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVG YSVATYIMGIKDRHSDNLMLTEDGKYFHIDFGHILGHGKTKLGIQRDRQPFILTEHFMTV IRSGKSVDGNSHELQKFKTLCVEAYEVMWNNRDLFVSLFTLMLGMELPELSTKADLDHLK KTLFCNGESKEEARKFFAGIYEEAFNGSWSTKTNWLFHAVKHY--------- >SIG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------~~~-~~~~~ ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~-~ ------+----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ ~~~~~~~~~~~------------------------------------------------- POT1 >H sapiens ------------------------------------------------------------ -----------------------------------M------------------------ ------------------------------------------------------------ SLVPATN--------YIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGT-------DYCSV VTIVD----QTNVKLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFA SLTFEGTLGAPIIPRTSSKYFNFTTEDHKMVE-------ALRVWASTHMSP-----SWTL LKLCDV--QPMQYFDLTCQLLGKAEV---DGASFLLKVWDGTRTPFPSWRVL---IQDLV LEGDLSHIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKLQSMNSENQTMLS-- --------LEFHLHGGTS---------YGRGIRVLPESNSDVDQLK-------------- ----------KDLESANLTA-----NQHSDVIC----------------------QSEPD DSFP----SSGSVSLYEVERCQQLSATILTDHQYLERTPLCAILKQKAPQQYRIRAKLRS YKPRRLFQSVKLHCPKCHLLQEVPHEGDLDIIFQDGATKTPDVKLQNTSLYDSKIWTTKN QKGRKVAVHFVKNNGILPLSNECLLLIEGGTLSEICKLSNKFNSVIPVRSGHEDLELLDL SAPFLIQGTIHHYGCKQCSSLRSIQNLNSLVDKTSWIPSSVAEALGIVPLQYVFVMTFTL DDGTGVLEAYLMDSDKFFQIPASEVLMDDDLQKSVDMIMDMFCPPGIKIDAYPWLECFIK SYNVTNGTDNQICYQIFDTTVAEDVI >H_glaber ------------------------------------------------------------ -----------------------------------M------------------------ ------------------------------------------------------------ SLTPVTN--------YIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGT-------DYCSV VTIVD----QTNVKLTCLLFSGNYEALPRIYKIGDIVRFHRLKIQVYKNEPQGITSSGFA SLTFEGTLGAPVIPRTSSKCFHFTAADHKMVE-------ALRIWSSTHISP-----SSTL VQLCDV--QPMQYFDLTCQLLGKAQV---DGASFLLKVWDGTRTPFPSWRVS---IEDHV LEGDLNHIRRLQNLTIDILVYDNHVQVAKSLKIGSFLRIYSLHTKLQSVTSESQAPLS-- --------LEFHLHGGTS---------YGRGVTVLPESNSDVDQLK-------------- ----------KALETADLTA-----AQHSDGLY----------------------QSDHE DSY-LTLSSSGSVSLYEVERCQQLSATILTDHQYLEKTPLCAILKQKAPQQYRIRAKLRS YKPKRLFQSVKLYCPKCHSLQEVPHEDNLDAVLRDGATKTPDTKLQNTPLYDSQIWTTED QGGRKVVIHFVKYNGILPLSNECLILIEGGTVGEICKLSSEFHSIIPVKSGPKDLELLDL SVPFLVQGRLYHYGCKQCSSLKPVQNLNSLVGETSWIPSSVAEVLGIVPLQHVFVMTFTL DDGTGVLEAYLMDSDKFFQIPASEVLRDDDLQRNMDLIMDMFCPPGTKIDAYPWMECVIK SYNVTNGMEQQICYQIFDTTVADDVI >M_brandtii --------------------MGCYMIYGCTVDTLLEEVVGSVLYSDTIAVDGFIVLSSPT ASKDGGHCLFLKALEDFKSTVYVYVKSIIDFSTESM------------------------ ------------------------------------------------------------ SLVPATR--------YTYTPLNELKGGMIVNVYGVVKFFKPPYLSKGT-------DYCSV VTIVD----QTNVKLTCLLFSGNYESLPIIYKNGDIVRFHRLKIQVYKNETQGITSSGFA SLTFEGTLGAPVIPRTSSKYFNFTTEDHKMVE-------TLRAWASTHISP-----SSTL VKLCDV--QSMQYFDLTCQLLGKAEV---DGASFLLKVWDGTRTPFPSWRVC---VQDLV FHGDLSHIRRLQNLAVDILVYDNHVQVAKSLKVGSFLRIYSLHTKLQSVNSENQATLLA- --------LEFHLHGGTS---------YGRGIRVLPESNSDVDQLK-------------- ----------KALECASLTA-----NQCSDGVC----------------------QSECE DSFP---TSSGSVSLYEVERCQQLSATILTDHQYLENTPLCAILKQKAPQRYRIRAKLRS YKPRKLFQSIKLYCPNCQSMQEVLHEGDLNRILQENATKTPNTKLQNTSLYDSKVWSTKD QGERQVAVHFVKNNGILPLSNDCLILIEGGTLSEIYKLADKFHSVIPVKSGHEDLELLDL SVPFLIQGKIHHYGCKKCSSLRPIQNLNNLDDKTSWIPSSVAEVLGIVPLQHVFVMTFTL DDGTGVLEAYLMDSDKFFHIPASEILTNDYLQESMDMIMNMLCPPGKKIDTYPWLECFIK SYNVTSGTEQQICYQIFDTTVADDVI >S franciscanus ------------------------------------------------------------ ---------RISFFGGLLMGHLAYKCANLNFSSYRI------------------------ ------------------------------------------------------------ ARARYRQK-------Y------------------------PP------GMFLSSLDYCMS LTIVDPSLPLENSGLKCVIFHQDIKKLPQVHSIGDIVRLHRLKIQQYNNQFQGAKGDGFS SLVFDGRSSAPVEPRSSSVNYTLSDQTY-MVQ-------ELRLWATKQTSVPLAAKSWTL SQIVSR-----EYFDLICQVVAVVII--PAESCVLIKVWDGTKY---KWYVRCLLVSKVQ VKWDTELACRAEGLILDVALYDNHMKAGRELQPGDFVRLYNLHAASYVPPNTAPAAASAN QDDSNTDMIELVLHRGTA---------YGRGLVVMKEYEEDVRVMKRVDIQIFHLSLALI LDLT------TILQPTPYIFDINLMNECRQSKCW-VAIS--DFNLLKE-GMTDGERSTPG QKNPENASWPSSFNSEQELQCMQQPIS-----GKVRVSKI-KRMMDHPPLLFRLKAAVVD YYPRTIQDFVHLFCSKCRMRYCL---------------------LVHSASISGKMHVYAN VIHRHCSFFRVYR-------QRC-------------------------CASAVSLRAQIM AARFYRESRDHLTR---------------------------------------------- ------------------------------------------------------------ -------------------------- >S_purpuratus MAALKEMSESDLAPELAGLQKISLSELHPSSTLLNRYVMGKMVDRSPLITKGKLPVLRLV LKESSSSHINVYTFGDFATGIDAYKNGDSVFISNAVIERSHTFTKDGHHKCQLMVHKGRS HALVWVCPQQEQGGSNTASTSAATATTTTPTTQKGPTTTTDHAGSEQGTPSKATHGRMVT ITAESSP--IKSKRTYEYKCLNDVKEARSVDVYGVVKFLQPPYKTKGPGMFLSSIDYCMS LTIVDPSLPQDNFGLKCVIFHQDIKKLPQVHSIGDIVRLHRLKIQQYNNQLQGAKGDGFS SLVFDGRPNAPVEPRSSSVNYTLSDQDKEKVQ-------ELRLWATQQTSVPLAGKSWTL SQIVSR-----EYFDLICQVVAVVII--PAESCVLIKVWDGTKY---KWPVRCLDVSKVQ VKWDTALACRAEGLILDVALYDNHMKAGRELKPGDYVRLYNLHAASYVPPNTAPAAASTN QDNGDTDMIELVLHRGTA---------YGRGLVVMKEYEEDVRVMKR---RMEELSTRKN QPSSNGQGSLNIGQGSLITGQVSHRSGQRSGSND-IELDNLDWEVLDSLGMTDGERSTQG QKNPENASWPSSLNSEQELQCMQQPISVITSYHDSRVSKI-KRMMDHPPLLFRLKAAVVD YYPRTIQDFVHLFCSKCRMSCRIP----------------TAKSAATNPPQDEQSRSDKD RKRKAEQ------------GQRC-------------------------CAPPVSLLAQIM AARFYRESRDHLTRSRGYNVAQPAVRMFFDAPPEAPTPSASASASELPGIG--------- --------------------------------------------DACNVYLWPW-EGFWQ TKRVCDQTP----------------- >L variegatus MAALKDMSESDVAPELSGLQMLPLVELYPSSSLLNRYVMVSVLYRYHLHIFCTASM--VY NDRKSIQHLPELHLYCPINDEGNTSLADTIFISNVMIERSHTFSKDNHHKCHLMVHKARS HARIWVSP--------SCYYMRIRCWIAISLSLVQPKNICSRIIKIHYSIFKLHSKFISQ FILQISKQISSSNRTYKYTCLNDIKETGSVDVYGVVKFFKPPYKTKGPGPSQPR-SYCMS LTIVDPSLPEEDSGLKCVLFQQDIKKLPEVLSKGDIVRLHRLRIQKYNSDFQGAKGNGFS SLVFDGRPNTPLEPRSSSVNYTLTDQDKEKVRIEAICLVHYKILMSIVLSSCKAAKARIA QIIIAQYSQQNQYAAYAYPSIGIYYIIIQIAGMIYIASICNEKYKNQKYAIQKSPSCIIC YHISYIYHAIIQQQISPVAYHYQH--------PPTY---CNLHFQIAIISAHEPEKSSSY Q-------YVKIIHKCQQVHIIQPIIDYYYAAYLICQIIAKIQTIN----PLAHQSTMMY QIPSYCHLMCQYFADAIIPAESCILIKCDDGSKYKLYMYIWIWSLM---------RIHCK IKYSHHYCY-----------CLFIFLSVITQYQDCQVSKI-KQMKDHPPHLFRLKATVVD YYPRTIQDFVHLFCSQCRMIYCYQ----------------PECS--AYPSYLYQNFHSPE RSYLTISISKLERLIRLHIIKKC-------------------AFIKPAKSGHP--IKFTF HYPLLEEIILQAIKSNGKSTSKVIYRFLS----PSIRPSACAR----------------- -------------------------------------------------------PCQIH SSKPAEYK------------------ >M_musculus ------------------------------------------------------------ -----------------------------------M------------------------ ------------------------------------------------------------ SLVSTAP--------YTYTPLNLLKEGTIANVYGVVKFFKPPYVSKGT-------DYCSV VTIVD----QTNVKLTCMLFSGNYEALPIIYKVGDIVRFHRLKIQVYKNELQGINCSGFA SLTFEGTVGMPVTARTSSKVFSFTPQDQKMVE-------ALRVWASKHISA-----SSTL VQLCDA--QPMQYYDLTCQLLGKAQV---DSTAFLLKVWDGTQTVLPSWRVS---TQDLT FEGDLSHIERLQSLVVDILVYDNHVQVARSIEVGCFLRLYSLHTKLQPGNSETSSSESLR --------LEFHLHGGTS---------YGRGIRVLPDTSPCVDQLK-------------- ----------KALEGANLPV-----TETSTGIC----------------------QSENG DSSALSNSGSGAVSPYEEERCQQVSATILTNHQHLEKTPLCAILTQKAPQQYRVRAKLRS YLPRRLSQSVKLLCPKCHSVQEVPHGDSLDKILQDAATEAPDIKLKATSLYYSKVWTTED QGGRQVAVHFVKNNGILPASSECLILIEGGRLCEVSKLSSKFHSVMPVRSGPESLELLTL SAPFLIQGKVHHYGCKQCSSLKPIQNLNSRFHKGPWTPSSVAEALGVVPLQYVFVMVFTL DDGTGVLEAYLKDSEHFFKIPASEVLTDDDLQRSLETIMDMICPPGIKVDAYPWLECLLK SYNVTIGTERRICYQIFDTTVAENVV >SIG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------+---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PRDX1 >H sapiens --------------------------------------------MSSGNAKIGHPAPNFK ATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGA SVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDK GILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFS KQK >H glaber --------------------------------------------MSSGNAKIGHPAPSFQ ATAVMPDGQFKDISLSDYKGKYIVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGA SVDSHFCHLAWINTPRKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDK GILRQITVNDLPVGRSVDETLRLIQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFS KQK >M brandtii MWCSSETLYPGLGFELPDSGASGVDPECVCASLRPRPRVAADSKMSSGNAKIGHPAPNFK ATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKINCQVIGA SVDSHFCHLAWINTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDK GILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFS KQK >S franciscanus ---------------------------------------------MAGKARVQEPAPYFE GTAVSTTGEFVDIKLSDYKGKKFILFFFSLSSTFVCPTEIIAFSDRADEFRAIDCEVLAA SIDSHFCHLAWINTPRKSGGLGQMKIPLLSDMKKQIAEDYGVLLKDAGIALRGLFLIDPE GVVRHMSINDLPVGRSVDETLRLVKAFQFVAEHGEVCPAGWTPDSETVSTNLHKA--LFV NI- >S purpuratus ---------------------------------------------MAAKARVQDPAPYFE GTAVSTTGEFVDVKLSDYKGKYLVFFFYPLDFTFVCPTEILAFSDRSDEFTKIGCEVLAA SCDSHFCHLAWTNTTKKLGGVGQLKIPLLSDMSGKIARDYGIMIEKEGISLRGLFIIDDK GTLRQITINDLPVGRSVDEVLRLVQAFQFTDKFGEVCPAGWKPGDDTIKPGVKESKEFFG KQ- >L variegatus -------------------------------------------HIFYSKQTLGWSL--YI LKVILRSLTELEFIFNDF---FAHLFFVLFCSTFVCPTEIIAFSDRVEEFRAINTEVVAA SVDSQFTHLAWINTPKKMGGVGELKIPLLSDMNGAIARDYGIMLEKEGVSLRGLFIIDDK GILRQITINDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTVSPDVKESKEFFG KK- >M musculus --------------------------------------------MSSGNAKIGYPAPNFK ATAVMPDGQFKDISLSEYKGKYVVFFFYPLDFTFVCPTEIIAFSDRADEFKKLNCQVIGA SVDSHFCHLAWINTPKKQGGLGPMNIPLISDPKRTIAQDYGVLKADEGISFRGLFIIDDK GILRQITINDLPVGRSVDEIIRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVNKSKEYFS KQK PSEN1 >H sapiens -MTELPAPLS-----YFQNAQ--MSEDNHLS-----------NTVRSQNDNRERQEH-ND RRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATI KSVSFYTRK-DGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCY KVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPL RLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERN ETLFPALIYSSTMVWLVNMAEGD-----------PEAQRRVSKNSKYNAESTERESQDTV AENDD------GGFSEEWEAQRDSHLGPHRSTP----ESRAAVQELSSSI--------LA GEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILI-------------- ------------------------------------------------------------ -----------------------------------------------------------G LCLT-------------------------------------------------------- ------------------------------------------------------------ -----LLLLAIFKKALPA------LPISIT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -FGLVF------------------------------------------YF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ATDY-------------LVQP-------------------------FMDQLAFH QFYI--------------------- >M_brandtii -MTELPAPLS-----YFQNAQ--MSEDNHLS-----------NIVRSQNDSRERHEHSNE RRRRGNPEPLSNGGPQGNTLQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATI KSVSFYTRK-DGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVALYKYRCY KVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITIALLIWNFGVVGMIAIHWKGPL RLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERN ETLFPALIYSSTMVWLVNMAKGD-----------PEAQRKVSKNSNYNEQNTGSESQNPV TESDD------GGFSEEWEAQRDSRLGPHHSTT----ESRSAVQEISSSI--------LA SEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIAPKVRRQSDTWGPW GDWSPCSRTCGGGISFRERFCYSQRRDGGSSCVGPARRHRLCHIESCPPGARDFRAEQCG EFDSREFQGRQYQWLPYYGAPNKCELACIPKGESFYYRHREAVVDGTPCEPGKPDVCVDG VCRVVGCDHKLDSSKQEDKCLQCGGDGTTCYPVTGTFDVSDLSRGYNQILIVPTGATSIR IEEVAASRNFLAVKSIQGEYYLNGHWTIEAARALPVASTILHYERGAEGDLAPERLHARG PTSEPLVIELISQESSPGVRYEYHLPLSTPRPGFSWSHGSWSDCSAECGGGHQSRPVFCT IDNEVYPDHMCQHQPRPATRRPCSPHSCPQTQRWKTGPWTPCSASCGGGSQSRSVYCVWS DGAGGEEAMEEVQCAGLPGKPATTQACNLQRCAAWREEPWGECSVSCGAGIRRRSVTCRG DEGSLLHASACSFKDQPPLTEPCVHDDCPRLSDQAWHAGAWSPCSKSCSSGTRRRQVACA IGPPSHCGSLQLWKPAEVEPCNTQPCPLPPGCPRHEELLEEGHRGEHLLGVRMRYSGKCG LAGVWGWPSGAVERDPVSHDEDPVSRDEDPVSRDEDPVSRDEDPVSRDEDPVSRDEDPVS RDEDPVSRDEDPVSRDEDPVSRDEDPVSRDEDPVSRDEDPVPQAHQPQAQQSEPTECRGS QFGCCYDNVASAAGPFGEGCVGQPSYAYPVGCLLPSALGSCTDWAPRWYFIASVGRCNRF WYGGCHGNANNFASEEECMSSCRGSQHTPRQPEPGAAGQSTHRAGAPLTWAEMLGGQHPP PTAPPPGEHSLSQGGGEGPGPGAEPLDLKPRGQPALPPHPAWRPRHLGRRRQPGAGGARI RQRTLPVSPGSVQHQQQPDGSLVISQVAVEDGGFYACVAFNGQDRDQQWVQLRVLGELTI TGLPSTVTVPEGDTARLLCVVAGESVNIRWSRNGLPIRADGHRVHQSPDGTLLIHNLRAG DQGSYTCSTYRGSQAVSRSTEVKVVPPALAAQPRDPGRDCMDQPELANCELILQAQLCGN EYYSSFCCASCSRAQPHAQPVWQQG >H_glaber -MTELPAPLS-----YFQNAQ--MSEDNHLS-----------NIARSQNDSRERQDC-SE RRRPGNPEPVSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATI KSVSFYTRK-DGQLIYTPFTEDTETVGQRALHSVLNAAIMISVIVVMTILLVVLYKYRCY KVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAMDYITVALLIWNFGVVGMISIHWKGPL RLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERN ETLFPALIYSSTMVWLVNMAEGD-----------PEAQRRVSKNSKYNTQSTEREAQDTG RENDD------GGFSEEWEAQRDSHLGPHRSTP----ESRAAVQELSSNT--------LT SEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILI-------------- ------------------------------------------------------------ -----------------------------------------------------------G LCLT-------------------------------------------------------- ------------------------------------------------------------ -----LLLLAIFKKALPA------LPISIT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -FGLVF------------------------------------------YF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ATDY-------------LVQP-------------------------FMDQLAFH QFYI--------------------- >S franciscanus MSAEILAPPSDGASNARRPIQ--VEGSNNPSYGTSVNAEVRGTSLQKQANAGNRPAN-QE RRRERDPPPM----------------EEEEEDEMLKYGAKHVIMLFVPVSLCMLVVVATI STVSFYTESGDVYLIYTPFHEKSDQAGTKAWNALANALIIIGIVLIMTIFLVVLYKYRCY KVSHYYGY--QIIQTYRHQCILNLRCIVTYNIPMDYFTIAVIMWNFGMVGMVSIHWKGPL RLQQLYLIVISALMALIFIKYLPEWTLWTILAAIAVYDEFAVLCPKGPLRMLVETAQERD EQIFPALIYSYEIHQILF----------------PPICMYVIFFIFY------------- ---------------------------------------PILITYFCLYI---------- -----TGGVKLGLGDFIFYSVLVGKAS--ASGDWTTTVACFVAILQ-------------- ------------------------------------------------------------ -----------------------------------------------------------G SQSE-------------------------------------------------------- ------------------------------------------------------------ -----LILLAIFKKALPA------LPISIA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -FGLVF------------------------------------------YF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------CTSN-------------LVFP-------------------------FTDELASQ QVYI--------------------- >S_purpuratus MSAEILAPTSDGASNARRPIQ--VEGSNNPSYGTSVNAEVRGTSVQRRANAGNRPAN-QE RRRERDPPPM----------------EEEEEDEMLKYGAKHVIMLFVPVSLCMLVVVATI STVSFYTESGDVYLIYTPFHEKSDQAGTKAWNALANALIIIGIVLIMTIFLVVLYKYRCY KVIHGWLVLSSLLLLFFFTFFYLQELLVTYNIPMDYFTIAVIMWNFGMVGMVSIHWKGPL RLQQLYLIVISALMALIFIKYLPEWTLWTILAAIAVYDLFAVLCPKGPLRMLVETAQERD EQIFPALIYSSTMVWLVGMADIDSPPPKSKAKQEPPVEEHTAEENATGGQEDQTVSSDQE VN---------GGFDTVFTERRERDLERSANSSVTSEDRRAAVRALRQNNGPSNRQPPVD EEEEEERGVKLGLGDFIFYSVLVGKAS--ASGDWTTTIACFVAILI-------------- ------------------------------------------------------------ -----------------------------------------------------------G LCLT-------------------------------------------------------- ------------------------------------------------------------ -----LILLAIFKKALPA------LPISIA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -FGLVF------------------------------------------YF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------CTSN-------------LVFP-------------------------FTDELASQ QVYI--------------------- >L variegatus ---QIEKKTLKVKQVYFTPLHEIVEGSNNPSYGTSVNAEVRGTSVQRQANAGNRQAN-QE RQRDRNPPPM----------------EEDEEDEMLKYGAKHVIMLFVPVSLCMLVVVATI STVSFYTESGDLYRIYTPFHEKSEQAGTKAWNALANALIIIGIVLVMTIFLVVLYKYRCY KTIEGFGHIMTIEQLYLSS---PSEKLVTYNIPMDYFTIAVIMWNFGMVGMVSIHWKGPL RLQQLYLIVISALMALIFIKYLPEWTLWTILAAIAVYGQFSVLCPKGPLRMLVETAQERD EQIFPALIYSCKKLFVQPIQRKQCF---------PLFCFIFHYCIICIPLIVKKNNLIPP THRISIVFRQVGPYCQVCKKKNILIIQYKQKCIVMIIDKPICCILISAIH--------HT SKISEITGVKLGLGDFIFYSVLVGKAS--ASGDWTTTVACFVAILI-------------- ------------------------------------------------------------ -----------------------------------------------------------V SCLT-------------------------------------------------------- ------------------------------------------------------------ -----LILLAIFKKALPA------LPISIA------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -FGLVF------------------------------------------YF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------CTSN-------------LVFP-------------------------FTDELASQ QVYI--------------------- >M_musculus -MTEIPAPLS-----YFQNAQ--MSEDSHSS-----------SAIRSQNDSQERQQQ-HD RQRLDNPEPISNGRPQSNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATI KSVSFYTRK-DGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVIMTILLVVLYKYRCY KVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYVTVALLIWNFGVVGMIAIHWKGPL RLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERN ETLFPALIYSSTMVWLVNMAEGD-----------PEAQRRVPKNPKYNTQRAERETQDSG SGNDD------GGFSEEWEAQRDSHLGPHRSTP----ESRAAVQELSGSI--------LT SEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILI-------------- ------------------------------------------------------------ -----------------------------------------------------------G LCLT-------------------------------------------------------- ------------------------------------------------------------ -----LLLLAIFKKALPA------LPISIT------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -FGLVF------------------------------------------YF---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------ATDY-------------LVQP-------------------------FMDQLAFH QFYI--------------------- >SIG ------------------------------------------------------------ -+---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PTEN >H sapiens -------------------------------------------MTAIIKEIVSRNKRRYQ ---------------------------------------EDGFDLDLTYIYPNIIAMGFP AERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQL ELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEV RTRDKKGVTI--PSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMF-SGGTCNPQF VVCQLKVKIYSSNSGPTRREDKFMYFEFPQP-LPVCGDIKVEFFHKQNKMLKKDKMFHFW VNTFFI------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PGPEETSEKVENGSLCD------ ------------------------------------------------------------ -----------------------------------------------------------Q EIDSICSIERA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DNDKEYLVLTL------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TKNDLDKAN-------------------------------------------- ------------------------------------------------------------ -------------KDKANRYFSPNFKVKLYFTKTV-EEP--------------------- ------------------------------------------------------------ ---------SNPEASSSTSVTPDVSDNE-------------------------------- ----------------------------------PDHYRYSDTT--DSDPENEPF----- ---------------------------------DEDQHTQITKV-------- >H glaber -------------------------------------------MTAIIKEIVSRNKRRYQ ---------------------------------------EDGFDLDLTYIYPNIIAMGFP AERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQL ELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEV RTRDKKGVTI--PSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMF-SGGTCNPQF VVCQLKVKIYSSNSGPTRREDKFMYFEFPQP-LPVCGDIKVEFFHKQNKMLKKDKMFHFW VNTFFI------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PGPEETSEKVENGSLCD------ ------------------------------------------------------------ -----------------------------------------------------------Q EIDSICSIERA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DNDKEYLVLTL------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TKNDLDKAN-------------------------------------------- ------------------------------------------------------------ -------------KDKANRYFSPNFKVKLYFTKTV-EEP--------------------- ------------------------------------------------------------ ---------SNPEASSSTSVTPDVSDNE-------------------------------- ----------------------------------PDHYRYSDTT--DSDPENEPF----- ---------------------------------DEDQHTQITKV-------- >M_brandtii MVDTGSTESEQGSEAHAPEQETVQLEVAAPCIPPSNHELVPVNAESAPKNVVDTGEGTFR GGNTRKSLEEDGSTRVTPSVQPHPQPVSLPRNMSVSQTMEDSCELDLVYVTERIIAVSFP STANEENFRSNLREVAQMLKSKHGGNYLLFNL-SERRPDITKLHAKVLEFGWPDLHTPAL EKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYMHYSNISASADQALDRFAMK RFYEDKIVPIGQPSQRRYVHYFSGLLSGTIKMNNKPLFLHHVIMHGIPNFESKGGCRPFL RIYQAMQPVYTSGIYNVQGDSQTSICITIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQ FHTCAIHDLGVVFGKEDLDDAFKDDRFPEYGKVEFVFSYGPEKIQGMEHLENGPSVSVDY NTSDPLIRWDSYDNFNGHRDDGMEEVVGHTQGPLDGSLYAKVKKKDSLNGSTGAVNATRP ALSATPNHVEHTLSVSSDSGNSTASTKTDKTDEPAPGPSSAPVALSPEEKRELDRLLSGF GLEREKPGNMYHTQHLRSRLAGGPAVPSASRHVVPAQVHVNGGALASERETDILDDELPN QDGHSVGSMGTLSSLDGITNTSEGGYPEALSPLTNGLDKPYAVEPMVNGGGYPYESASRA VPAHAGHLAPMRPSYSAQEGLAGYQREGPHPAWSQQVTTSHYGHDPSSMFRSQSFPDTEP QLPPAPARGGSSREAVQRGLNSWQQQQQQQQQQQQQQQQPHPPPRQQERAHLESVRPSRP GPQPLAETPTPGLPEFPRAASQQEIEQSIEALNMLMLDLEPSSAAAPLHKSQSVPGAWPG ASPLSSQPLSGSSYQTHPLTQSRSGYIPSGHSLGTPEPAPRASLESIPQGRSYSPYDYQA CLAGPNQSYRPKSPASSSSLPAFLPTNHSPPGPQQPPTSLPGLAAQPQLPPKEVTSDPSR TPEEEPLNLEGLVAHRVAGVQAREKQPAEPPAPLRRRAASDGQYENQSPEPSSPRSPGVR SPVQCVSPELALTIALNPGGRPKEPHLHSYKEAFEEMEGTAPSSPPPSGVRSPPGLAKTP LSALGLKPHNPADILLHPKGEEDGGQEVMEPLGEPRSYVESVVRTAVAGPRSQDPEPKSF SAPAAQAYGHDTPLRNGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGESSDQGPRTPT QPLLDSGFRSGSLGQPSPSAQRSYQSSSPLPTVGSSYSSPDYSLQQFSSPESQARPQFNA AGVHAVPGSPQARHRTVGTNTPSSPGFGRRAVNPGMAAPSSPSLSHRQVMGPPATGFHGN VVSSPQSSAVTTPGSPSLGRHPGAHQASGLHGSVAVTPGSPSRGQQPGAHQASGLPGNVA TTPGSPSLGRHPGAHQGNLASNLHGNTISSPGSPILGRHLGASGSVVPGSPSLDRHVAYG GYSTPEDRRPTLSRQSSASGYQAPSTPSFPVSPAYYPGLSSPATSPSPDSAAFRQGSPTP ALPEKWRMSMGDRVGSLPNYATINGKVSSSPVASGMSSPSGGSTVSFSHTLPDFSKYSMP DNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKV SSPPPTIMQQNKKGDMTHELVRHFLIETGPRGVKLKGCPNEPNFGSLSALVYQHSIIPLA LPCKLVIPNRDPTDDSKDSSGPANSTTDLLKQGAACNVLFVNSVDMESLTGPQAISKATS ETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEG GAPAKLFGFVARKQGSTTDNACHLFAELDPNQPASAIVNFVSKVMLSAGQKR >S franciscanus -----------------------------------------------FQ----------- -------------------------------------------------LYGQQYSFVFP -----------------------------YVRCSERNYDTSKFYHRVAHYPFDDHNPPRI ELIKPFCEDLMQWLAADKQNVAAIHCKAGKGRTHTYICAYMLHRRLYQSASEALDFYASK RTKNRQGVTI--PSQRRYVQYYGELIKRELEYKPETLLLKRIQLYTIPMM-SGGSCAPAF TIYQQKVKIHSQQAYKVAKKERSVRCEFPLP-VPICGDIKIEFFNKPNK-LKK------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------VSHVASK------ ------------------------------------------------------------ -----------------------------------------------------------S NLSSC------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------LLLFQVLSL------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------IFF---LQVICYFKRVENEKP--------------------- ------------------------------------------------------------ ---------RRPSGDSNDRSSGTSSDHE-------------------------------- ------------------------------------NSDGGDIS--ETDSESE-W----- ---------------------------------D---VTEITHV-------- >S purpuratus -------------------------------------------MNVIAD----------- -------------------------------------------------IYPNIIAMGFP AESLEGVYRNKLEVVVKFFNEKHGERYKVYNLCSERNYDTTKFYNRVAHYPFDDHNPPRL ELIKPFCEDLDNWLGADGQNVAAIHCKAGKGRTGVMICAYMLHRRLYQTASEALDFYASK RTKNRKGVTI--PSQRRYVEYYGNLIVRELEYKPTTLLLTRIDLETVPMF-NGGSCAPAF VIYQQKVKIFSSQPYEVAKKERSVRCEFPLP-VPICGDIKIEFFNKPNK-LKKDRMFHFW FNTFFVANS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NLLNSSSQQDLANNGSS------ ------------------------------------------------------------ -----------------------------------------------------------D NSSHCSEDNME------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------ALDADCTVLRL------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------QKDQLDRAN-------------------------------------------- ------------------------------------------------------------ -------------KDKTNKWYSPNFKVICYFKRVENEKP--------------------- ------------------------------------------------------------ ---------RRPSGDSNDRSSGTSSDHE-------------------------------- ------------------------------------HSDGGDIS--ETDSESE-W----- ---------------------------------D---VTEITHV-------- >L variegatus -------------------------------------------VDVIAD----------- -------------------------------------------------IYPNIIASSFP ASGKQSIYRNPISEVSKFLNTKHPDHYKVFNLCSERNYDTSHFYHRVAHYPFDDHNPPRI ELIRPFCEDLMQWLAADKQNVAAIHCKAGKVKSYLSSLCETPYISIIIAIPAPI--HHKI FQLAAFGVTI--PSQRRYVEYYGDLIIRELEYKPTTLLLTRIDLETVPMF-NGGSCAPAF VIYQQKVKIFSSQPYEVAKKERSVRCEFPLP-VPICGDIKIEFFNKPNK-LKKSIPLHQK LDIKYYMRL--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PKPIIQLYSYPSASAWK------ ------------------------------------------------------------ -----------------------------------------------------------S SPEQCV------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------ESKYVIIGFVRR---------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------RKDQLDRAN-------------------------------------------- ------------------------------------------------------------ -------------KDKTNKWYSPNFQVICYFKRVENEKP--------------------- ------------------------------------------------------------ ---------RRPSGDSNDHSSGTSSDHE-------------------------------- ------------------------------------NSDGGDIS--ETDSESE-W----- ---------------------------------D---VTEITHV-------- >M musculus -------------------------------------------MTAIIKEIVSRNKRRYQ ---------------------------------------EDGFDLDLTYIYPNIIAMGFP AERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQL ELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEV RTRDKKGVTI--PSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMF-SGGTCNPQF VVCQLKVKIYSSNSGPTRREDKFMYFEFPQP-LPVCGDIKVEFFHKQNKMLKKDKMFHFW VNTFFI------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------PGPEETSEKVENGSLCD------ ------------------------------------------------------------ -----------------------------------------------------------Q EIDSICSIERA------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------DNDKEYLVLTL------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------TKNDLDKAN-------------------------------------------- ------------------------------------------------------------ -------------KDKANRYFSPNFKVKLYFTKTV-EEP--------------------- ------------------------------------------------------------ ---------SNPEASSSTSVTPDVSDNE-------------------------------- ----------------------------------PDHYRYSDTT--DSDPENEPF----- ---------------------------------DEDQHSQITKV-------- SGK1 >H sapiens MTVKTEAAKGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQ-KIANNSYACKHPEVQSILK ISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSD---------FHFLKVIGKGSFG KVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTAD KLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL DSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEM LYGLPPFYSRNTAEMYDNILNKPLQLKPNI-TNSARHLLEGLLQKDRTKRLGAKDD-FME IKSHVFFSLINWDDLINKKITPPFNPNVSGPNDLRHFDPEFTEEPVPNSIGKSPDSVLVT ASVKEAAEAFLGFSYAPPTDSFL-- >H glaber MTVKTEAARGTVTYSRMRGMVAILIAFMKQRRMGLNDFIQ-KIANNSYACKHPEVQSILK ISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSD---------FHFLKVIGKGSFG KVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTAD KLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL DSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEM LYGLPPFYSRNTAEMYDNILNKPLQLKPNI-TNSARHLLEGLLQKDRTKRLGAKDD-FME IKSHVFFSLINWDDLINKKITPPFNPNVSGPSDLRHFDPEFTEEPVPNSIGRSPDSILIT ASVKEAAEAFLGFSYAPPMDSFL-- >M brandtii MTVKTEAARGTLTYSRMRGMVAILIAFMKQRRMGLNDFIQ-KIANNSYACKHPEVQSILK ISQPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSD---------FHFLKVIGKGSFG KVLLARHKAEEAFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTAD KLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSMNIVYRDLKPENILL DSQGHIVLTDFGLCKENIEPNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEM LYGLPPFYSRNTAEMYDNILNKPLQLKPNI-TNSARHLLEGLLQKDRTKRLGAKDD-FME IKNHVFFSVINWDDLINKKITPPFNPNVSGPSDLRHFDPEFTEEPVPNSIGRSPDSILLT ASVKEAAEAFLGFSYAPPVDSFL-- >S franciscanus ---------QDARSEIIPYPVIPILFF----SGEVQNFLSLDNPRNNPDNNVTDENNIDF FSDPNDPN--------------TINLGPSANPSARPSD---------FDFLKVIGKGSFG KVLLAKHKIDGKVYAIKVLKKAAIIQDHDAKHIMTEKSVLLKASKHPFLVSLHYSFQTAD KLYFVLEYVNGGELFFHLQREKKFPEERARFYAAEIASALAYLHAHGIIYRDLKPENILL DADGHVKLADFGLCKEGIAAKKTTSTFCGTPEYIAPEVIEEKGYGHAVDWWALGVVLYEM LVGTPPFYTDSIEQLFSLILNKPLKMPSSLFSPAAKSLLSELLEKKPEKRI--------- ---ISFCIAPPLAKIILLKAIVKYVSLQSDSMDVKNIDPEFVREPVPNSVGKSVDPNTVS ASVQDADNVFEGFTYVPPTVGLDDP >S purpuratus ----------MSVLSKGAGTVQKRGKFL---CGEVQNFLSLDNPRNNPDNSVADENNTDF FSDPNDPN--------------TINLGPSANPSARPSD---------FDFLKVIGKGSFG KVLLAKHKIDGKVYAVKVLQKAAIVKRNEAKHIMAERSVLLKNLKHPFLVSLHYSFQTAD KLYFVLDYVNGGELFFHLQREKSFPEVRAKFYAAEIASAIGYLHSLDIIYRDLKPENILL DHDGHVRLTDFGLCKEGIAAKKTTSTFCGTPEYLAPEVLRKQEYDRSVDWWCLGAVLFEM MSGLPPFYSRDTAEMYDNILNKPLRMRSSVFSPSAKGLLEGLLHKERAKRLGAGDKGFKA VKHHEFFSSISWSDLDGKKITPPYNPRVSDSMDVKNIDPEFVREPVPNSVGKSVDPNTVS ASVQDADNVFEGFTYVPPTVGLDDP >L variegatus --------LLKLLTSHIKKLLFPILF-----SGEVQNFLSLDDPRNNSDNSVTDENNTDF FSDPNDPN--------------TIFLGPSANPSARPSD---------FDFLKVIGKGSFG KVLLAKHKIDGKVYAIKILQKAAIIQRHQAKHIMAEKHVLETASKHPFLVSLHSCFQTDD RLYFVMEYVSGGDLFFHIQRQRRFDEETARFYAAEIVSALEYLHSLGIVYRDLKPENILL DADGHVKLADFGLCKEGIGYGRTTSTFCGTPEYLAPEIILEQGYDRSVDWWSLGILLFEM LSGLPPFHGETPDQLFRCIIHGKWRMLLKSIDFVCLG-IALLLHKERAKRLGAGEKGFKT VKHHEFFSSISWSDLDAKKITPPYNPRVSSTMDVKNIDPEFVREPVPNSVGKSVDPNTVS ASVQDADNVFEGFTYVPPTVGLDDP >M musculus MTVKAEAARSTLTYSRMRGMVAILIAFMKQRRMGLNDFIQ-KIASNTYACKHAEVQSILK MSHPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSD---------FHFLKVIGKGSFG KVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTAD KLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILL DSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEM LYGLPPFYSRNTAEMYDNILNKPLQLKPNI-TNSARHLLEGLLQKDRTKRLGAKDD-FME IKSHIFFSLINWDDLINKKITPPFNPNVSGPSDLRHFDPEFTEEPVPSSIGRSPDSILVT ASVKEAAEAFLGFSYAPPVDSFL SIRT1 >H sapiens MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV PAAARGCPGAAA---AALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLA DNLYDEDDDDEGEEE---EEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSS DWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIP-PPELDDMTLWQIVINIL---SE PPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDL PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTL EQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEP-LAIMKP EIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPL PHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITE-----KPPRTQKELAYL SELPPTPLHVSED----------------------------------------------- -------------------------------------------------------SSSPE RTSPPDSSVIVTLLDQAAKSN-DDLDVSESKGCMEEKPQEVQTS-RNV-------ESIAE QMENPD-------------------------------------------LKNVGSSTGEK NERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSS CGSNSDSGT---CQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAI NEAISVKQE--------------------------------------------------- ------------------------------------------------------------ -----VTDMNYPSNKS-------------------------------------------- ----------------------- >H_glaber MADEAALTLQP-GSPSAAAAEREAASPPAGEPLRKRPRREGSVPGRSPSEPSG------- -AAAGGCP-AAA---AALWREA---AAVAGGEREAQGTAGVGEGDNGPGLQGLALELPPG DDFDDEDDDDDDDDDDEGEEEEEAAIGYRDNLLLSDDIITNGFHSCESDDDDRASHASSS DWTPRPRI--------------------------------------VWQIVINIL---SE PPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDL PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHQFIALSDKEGKLLRNYTQNIDTL EQVAGIQRIIQCHGSFATASCLICRYKVDCEAVRGDIFNQVVPRCPRCPPDEP-LAIMKP EIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPL PHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITE-----KPPRTQKELVHL SQLPPTPLHISED----------------------------------------------- -------------------------------------------------------SSSPE RTSP-DSSVIVKLLDQATKSSVDDLDGAESKGYVEEKPQEVQASTRNA-------ESI-- NVENPD-------------------------------------------LKD-SSNTAEK SGRTSVAETVRKCWPNRLAKEQISKRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSS CGSNSDSGT---CQSPSLEEPLEDESEIEEFYNGLEEDPDAPEITGGTGFGANGGDQEAV NEAISTKQE--------------------------------------------------- ------------------------------------------------------------ -----VTDRNYPSNKS-------------------------------------------- ----------------------- >M_brandtii MAN-----LKS-GRVTKLSLTREEMS----RGVVRGQHWEGEVPFGFPSESQG------- ---------FST---KML------------------------------------------ -----------------------------DNLLFGDEIITNGFHSCESDEDDRASHASSS DWTPRPRIGPYAFVQQHLMIGTDPRTILKDLLPETIP-PPEWDDMTLWQIVINIL---SE PPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDL PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTL EQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEP-LAIMKP EIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPL PHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPIKLSEITE-----KPPRTQKELAHL SELPPTPLNISEG----------------------------------------------- -------------------------------------------------------SSSPE RTSPPDSSVIVTLLDHAMKSNIDDPDVSESKDCMEEKSQAVQTSTRSI-------ESVTE QLESPD-------------------------------------------LKNISSNTVEK NERTSVAETVRKYWPAKIAKEQISKRLDGNQYLFLPPSRYIFHGAEVYSDSEDDVLPSSS CGSNSDSGT---CQSPSLEEPLEDESEIEEFYNGLEDDPDINERAGGTEFGADEGDQEAV NEAISMKQE--------------------------------------------------- ------------------------------------------------------------ -----ATDINYPSNKS-------------------------------------------- ----------------------- >S franciscanus ---------------------------------------FIPICL-YPLQP--------- ------------------------------------------------------------ ------------------------------------------------------------ --------GPMGWLQKQMMSGTNPRSILMRIIPSGMTIPEEMDEFEMWSIIAEYLRSIDE PPPRQKLEQYNTFDDAIQLLKSCKNILVIYGAQVSVSIAIPDFRSRDGVYARLAVDFPDL PDPQAMFEISYFRKDPRPFYKFAQELFPGQFKPSTSHKFISQLEQQQKLLRNYTQNIDTL EQAAGISGVIQCIGKFATATCTRCGLSVDSDAIRDDVFNQVVPICPQCGPYTPQMAVLKP DIVLFIETYSYHSYDKLNDDKETADLLIVMGSSLKVRPVATIASLLPKKVPQILINREPL PHLNFDIELLGDCDVIINEILHRLGDGWNHVCQSQQRLTETTYIPNVSKPKEPQQAQKAV LDEGETTVDQKPD----------------------------------------------- -------------------------------------------PAGRIDNEVSASNPVNV KSEEDSQQSLSSLKEESQVYSGDDKNEGSNAGEGDDRLASSNSQESPILPEGPVKQSCDE RLQAPENQTSSEHHINGLTNEGKVHVDALPCSQSKTNYSPSSMSDSLQSVDEVENALVSS EPQTSKTAPSESSQSQTAHDQTVQRNSAAEQYMLFQRTLDLIGNSSTGASSSDVKVGNDS VATGESESTQTHVDSDCKEPSTDVKTEAEELGSCVNEKDRTKSQDAKDDIDSEVGNVSSS SGSVVDHREQASPAPDSEAKPSPSTSAAAKTPRATISTHLK------------------- ------------------------------------------------------------ -----GKDQHSFRNSEIVNV---------------------------------------- ----TFITYLPIYLTNVWNFNFY >S purpuratus ---------------------------------------MGLGDIRPDSLA--------- ------------------------------------------------------------ ------------------------------------------------------------ --------GPMGWLQKQMMSGTNPKSILMRIIPSGMTIPEEMDEFEMWSIIAEYLRSIDE PPPRQKLEQYNTFDDAIQLLKTCKNILVLTGAGVSVSCGIPDFRSRDGVYARLAVDFPDL PDPQAMFEISYFRKDPRPFYKFAKELFPGQFKPSTSHKFISQLEEHQKLLRNYTQNIDTL EQAAGIKGVIQCHGSFATATCTRCGLSVDSDAIRDDVFNQMIPICPQCGPDTPDMAVLKP DIVFFGEGLPNHFYDKLNDDKETADLLIVMGSSLKVRPVATIPSLLPKKVPQILINREPL PHLNFDIELLGDCDVIINEILHRLGDGWDHVCQSQQRLTETTHIPNGFKPKESRQARKAV LEEGGTTVDQRPDPVLDEGETTVDQRPDPVLDEGETTVDQRSNPVLDEGETTVDQKPDPV LDEGETTVDQKPDPVLDEGETTVDQKPDPVLDEGETTVDQKPDPAGRIDQEESVSNPVNV KSKEDTQHSLSSLKEEGQVSSGDDKNEGSKAGEGDDRLARSNSQDSPISPEGHVKQSCDE RLQAPENQTSLEHHINGLTNEGKIHVDALPCSRSETNCSPSSNSDRLQSVDEVENALASS EPQTSKTIPSESSQSHTAQDQTAQRNSAAEQYMLFQRTLDSIGNSSTGASSLDVMAGNDS VASGESESTQTHVASDCKEPSTDVKAEAEDLGLCVNETDRTNSQ---DDLNSEVGNVSSS SGSVLEHREQASPAPDSEAKPSPSTSAAAKTPRATISTQLKESSFLFIPPMRYVFHGAEV FLSDDDNEIEHGLEGLNKDMDINDLHNELENGDLHNDLGSGDLHNELENGDLHNHLHNGD DLPDLSEEDHSPAKEKTVSLDDLTPTVPSTDRETSQYGQSASKAQCVPETNGRDGSPFEA PSGETVYTHIDLPVTP------- >L variegatus ---------------------------------------HIAIHSTYTTPP--------- ------------------------------------------------------------ ------------------------------------------------------------ --------GPMGWLQKQMMSGTNPRSILMRIIPSGMTIPDDMDEFEMWSIIAEYLRSIDE PPPRQKLEQYNTFDDAIQLLNSCKNILVLTGAGVSISCGIPDFRSRDGVYARLAVDFPDL PDPQAMFEISYFRKDPRPFYKFAKELFPGQFKPSPSHKFISQLEQHDKLLRNYTQNIDTL EQCAGITRVIQCHGSFATATCTRCGLRVDSDAIREDVF-KVVPVCPQCGPDTPEMAVLKP DIVFFGEGLPNHFYDKLNDDKEAADLLIVMGSSLKVRPVATIPSLLPKDVPQILINREPL HHLNFDIELLGDCDVIINEILHRLGDGWNHVCQSQQRLTETTDIPNIPKPKEANKDVHTL LDKSESTVEEKPN----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VTS---------------------------------------------------- ----------------------- >M musculus MADEVALALQAAGSPSAAAA-MEAASQPADEPLRKRPRRDGPGLGRSPGEPSA-----AV APAAAGCEAASAAAPAALWREA--AGAAASAEREAPATAVAGDGDNGSGLR---REPRAA DDFDDDEGEEEDEAA---AAAAAAAIGYRDNLLLTDGLLTNGFHSCESDDDDRTSHASSS DWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIP-PPELDDMTLWQIVINIL---SE PPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDL PDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTL EQVAGIQRILQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEP-LAIMKP EIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPL PHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITE-----KPPRPQKELVHL SELPPTPLHISED----------------------------------------------- -------------------------------------------------------SSSPE RTVPQDSSVIATLVDQATNNNVNDLEVSESS-CVEEKPQEVQTS-RNV-------ENI-- NVENPD-------------------------------------------FKAVGSSTADK NERTSVAETVRKCWPNRLAKEQISKRLEGNQYLFVPPNRYIFHGAEVYSDSEDDVLSSSS CGSNSDSGT---CQSPSLEEPLEDESEIEEFYNGLEDDTERPECAGGSGFGADGGDQEVV NEAIATRQE--------------------------------------------------- ------------------------------------------------------------ -----LTDVNYPSDKS-------------------------------------------- SIRT2 >H sapiens ----------------------------------MDFLRNL---FSQTLSLGSQKER--- --LLDELTLEGVARYMQSERC--RRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLP YPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLE RIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQ--SLVKPD IVFFGESLPAR------FFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLI NKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLV RREHAS-------IDAQSGAGVPNPSTSAS----------PKKSPPPAKDEARTTEREKP Q----- >H glaber --------MRSTRAHTVKDTDLDAEEGASGGEAEMDFLRSL---FSQTLGLGSQKER--- --LLDELTLEGVVRYMQSERC--QRVICLVGAGISTSAGIPDFRSPTTGLYANLEKYHLP YPEAIFEIGYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLE RVAGLEPEDLVEAHGTFYTSHCTSQLCRHEYTLGWMKEKLFSEVTPKCEKCQ--SVVKPD IIFFGENLPSR------FFSCLQSDFRKVDLLIIMGTSLQVQPFASLIGKAPLSTPRLLI NKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLV RKEHAH-------IDAQSGSSTPNPTTAAS----------PRTSPPPGKAEAKTTDGEKP Q----- >M brandtii PPASDPLETQAGKVQEAQDSDSDTEEGAAGGEAEMDFLRNL---FSQTLGLGTQKER--- --LLDNLTLEGVAHYMLSERC--RRVICLVGAGISTSAGIPDFRSPSTGLYANLQKYHLP YPEAIFEIGYFKKHPEPFFALAKELYPGQFKPTLCHYFIRLLKEKGLLRRCYTQNIDTLE RVAGLEPEDLVEAHGTFYTSHCISPLCRKEYTLSWMKEKIFSEVTPKCENCQ--SVVKPD IVFFGENLPAR------FFSCIQSDFLNVDLLIIMGTSLQVQPFASLISKAPLSTPRLLI NKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLV RKEHAS-------IDAQSGLGSPNPTTSAS----------PRKSPPAAKEEARTTEGEKP Q----- >S franciscanus ------------------------------------------------------------ ------------------------------------------------------------ --------------PEPFFTLSKELFPGAFYPTPSHFFIRLLHEKGILQRHYTQNIDTLD RIAGVPDELIMEAHGSFHTGHCLN--CNEIYTEESMRGKIRHIL---------------- ----------------------------------------------MLYKDHISSPQI-- ---------SFL------------------------------------------------ ------------------------------------------------------------ ------ >S purpuratus --------MSAKNEGAAAGADDKEGGQSESVDSQVESLRNFLGRFHLSAGSSGQEEKPKP EQLLKELTLEGIADFIKEGKC--KKVIVMSGAGISTSAGIPDFRTPGTGLYDNLQKYNLP NPQAIFEIGFFKQNPEPFFTLSKELFPGAFYPTPSHFFIHLLHEKGILLRHYTQNIDGLD RMAGVPDELIMEAHGSFHTGHCLN--CNEMYTEESMREKIMADLIPRCAKCNETGVVKPD VVFFGESLPPR------FPTLVSEDFPQCDLLIVMGTSLVVQPFASLIDKVPETTPRLLI NMEKSGKADPMM-MMFGFPSGMDFDSDDKYRDVAYIGPCDEGCEKLAGFVGWKKEMTVLV NKGEAK-------KKKKGETESPTKDETAKTPTSATKDQKPKTSASPGKKSSASPTKDKK PSSKKD >L variegatus --------------------TYFSGIIRLISIIQSNIISSL---CHNSLPMNNSIMT--- --KFIHLACHVSHAISIPYICIYHLLISQLTCILSIAAGIPDFRSPGTGLYDNLQKYNLP NPQAIFEIGFFQENPEPFFTLSKELFPGAFFPTPSHFFIRLLHEKGILLRHYTQNIDTLD RIAGVPDEKIMEAHGSYHTGHCLN--CNEEYTEELMRGKHKKVLNMYIAAMF-------- LAFSGGRVGMKVVIEYCYKTCFFADFPQCDLLIVMGTSLVVQPFASLVDKYVITSTTFPL MTKTSSYIHQLCSLALKLQIIIAPPPPAYYCNLVY------EVLNFIKSFSFITYFILLI YANYNSAVNLMKYFTATSFILVTGDSDEMYMKKLVLKCILLFLHSLPESSLNGCPLQ--- ------ >M musculus ----------------------------------MDFLRNL---FTQTLGLGSQKER--- --LLDELTLEGVTRYMQSERC--RKVICLVGAGISTSAGIPDFRSPSTGLYANLEKYHLP YPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGLLLRCYTQNIDTLE RVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQ--SVVKPD IVFFGENLPSR------FFSCMQSDFSKVDLLIIMGTSLQVQPFASLISKAPLATPRLLI NKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCDQGCLALADLLGWKKELEDLV RREHAN-------IDAQSGSQAPNPSTTIS----------PGKSPPPAKEAARTKEKEEQ Q----- TEP1 >H sapiens MEKLHGHVSAHPDILSLENRCLAMLPDLQPLEKLHQHVSTHSDILSLKNQCLATLPDLKT MEKPHGYVSAHPDILSLENQCLATLSDLKTMEKPHGHVSAHPDILSLENRCLATLPSLKS TVSASPLFQSLQ---ISHMTQADLYRVNNSNCLLSEPP-SWRAQHFSKGLDLSTCPIALK SISATETAQEATLGRWFDSEEK-----KGAETQMPSYSLSLGEEEEV-EDLAVKLTSGDS ESH--------------PEPTDHVLQEKKMALLSLLCSTLVSEVNMNNTSDPTLAAIFEI CRELALLEPEFILKASLYARQQLNVRNVANNILAIAAFLPACRPHLRRYFCAIVQLPSDW IQVAELYQSLAEGDKNKLVPLPACLRTAMTDKFAQFDEYQL--AKYNPRKHRAKRHPRRP PRSPGMEPPFS--HRCFPRYIGFLREEQRKFEKAGDTVSEKKNPPRFTLKKLVQRLHIHK PAQHVQALLGYRYPSNLQLFSRSRLPGPWDSSRAGKRMKLSRPETWERELSLRGNKASVW EELIENGKLPFMAMLRNLCNLLRVGISSRHHELILQRLQHAKSVIHSRQFPFRFLNAHDA IDALEAQLRNQA----------------------------------------LPF---PS NITLMRR--------ILTRNEKN-RP---RRRFLCHLSRQQLRMAMRIP----------V LYEQLKREKLRVHKA--------------------------------------------- --------------------------------------------------RQWKYDGEML NRYRQALETAVNLSVKHSLPLLPGRTVLVYLTDANADRLCPKSNPQG------------- --------PPLNYALLLIGMMIT-RAEQVDVVLCGGDTLKTAVLKAEEGILKTAIKL-QA QVQEFDENDG-------------------------------------------------- ------------------------------------------------------------ --------------WSLNTFG--------------------------------------- ----------------------------------------KYLLS--LAGQRVPVDRVIL LGQSM-----DDGMINVAKQLYWQRVNSKCLFVGILLR--RVQYLSTDLNPNDVTLSGCT DAILKFIAEHGASHLLEHVGQMDKIFKIPPPPGKTGVQSLRPLEEDTPSPLAPVSQQGWR SIRLFISSTFRDMHGERDLLLRSVLPALQARAAPHRISLHGIDLRWGVTEEETRRNRQLE VCLGEVENAQLFVGILGSRYGYIPPSY-NLPDHPHFHWAQQYPSGRSVTEMEVMQFLNRN QRLQPSAQALIYFRDSSFLSSVPDAWKSDFVSESEEAARRISELKSYLSRQKGITCRRYP CEWGGVAAGRPYVGGLEEFGQLVLQDVWNMIQKLYLQPGALLEQPVSIPDDDLVQATFQQ LQKPPSPARPRLLQDTVQRLMLPHGRLSLVTGQSGQGKTAFLASLVSALQAPDGAKVAPL VFFHFSGARPDQGLALTLLRRLCTYL---RGQLKEPGALPS--TYRSLVWELQQRLLPKS AESLHPGQTQVLIIDGADRLVDQNGQLISDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQ GAHVLALGPLEASARARLVREELALYGKRLEESPFNN----------------------- --------------QMRLLLVKRE-SGRPLYLRLVTDHLRLFTLYEQVSERLRTLPATVP LLLQHILSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVWRTLPKGTKSWEEAVA AGNSGDP-YPMGPFACLVQSLRSLLGEGPLERPGARLCLPDGPLRTAAKRCY--GKRPGL EDTAHILIAA---QLWKTCDADASGTFRSCPPEALGDLPYHLLQSGNRGLLSKFLTNLHV VAAHLELGLVSRLLEAHALYASSVP-----KEEQKLPEADVAVFRTFLRQQASILSQYPR LLPQQAANQPLDSPLCHQASLLSRRWHLQHTLRWLNKPRTMKNQQSSSLSLA-VSSSPTA VAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSGCDGISACLFLSDDTLFLTAFDGLL ELWDLQHGCRVLQTKAHQYQITGCCLSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPK SLNCVAFHPEGQVIATGSWAGSISFFQVDGLKVTKDLGAPGASIRTLAFNVPGGVVAVGR LDSMVELWAWREGARLAAFPAHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGH LGSLSLSPALSVALSPDGDRVAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPK VLVSGAEDGSLQGWALKECSLQSLWLLSRFQKPVLGLATSQELLASASEDFTVQLWPRQL LTRPH-KAEDFPCGTELRGHEGPVSCCSFSTDGGSLATGGRDRSLLCWDVRTPKTPVLIH SFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQRLGQFLGHQSAVSAVAAVEEH VVSVSRDGTLKVWDHQGVELTSIPAHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGAT RLWHPLLVCQTHTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSS AAVTAVAWAPDGSMAVSGNQAGELILWQEAKAVATAQAPGHIGALIWSSAHTFFVLSADE KISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLILAKADLKLLCMKPG DAPSEIWSSYTENPMILSTHKEYGIFVLQPK-DPGVLSFLRQKESGEFEERLNFDINLEN PSRTLISITQAKPESESSFLCASSDGILWNLAKCSPEGEWTTGNMWQKKANTPETQTPGT DPSTCRESDASMDSDASMDSEPTPHLKTRQRRKIHSGSVTALHVLPELLVTASKDRDVKL WERPSMQLLGLFRCEGSVSCLEPWLGANSTLQLAVGDVQGNVYFLNWE >H_glaber MEKHHGPVSVHPDILSLENR------------------------------CLAMLPNLQP MERPRGYMPAHSDILCLENRCLARISDLKSTGKPHGHGAAHPSILSVENGCLSSIPSVKS SMSASPLLQCLQ---PPCMMHANVSSLNTSKCLLSEPPSSRRAQC--------------- -VSATETVQGALC---YSKEEKKSEAMEGDGDQMPIYSLSLGEEEEVEEELALQLASGHS ESH--------------PETSDWDLQEKKMCLMTILCSIVASNVNMNNARDLSR-SIHCI CSELSSLEPEFILKESLYARQQLNLRDVANKVLAIAALLPACRPHLRRYFCAIVHLPSDW IQVAEFYQDLAKGDENKLVPLPACLRAAMTDKFAQFDEYQL--AKYNLRQHRAKRRPRRP PRPPKTEPPFSG-RLHVLGFLWSLTDVQTKFEVAYDA--EKKNPSWFTLKKLVQRLHIHK PAQHVQALLGYRYPSSLQLFSQSRLPGPWDSSRAGKRMKLPRPETWDRKLSLQGNKASVW EELIDSGKLPFMAMLRNLCNLLRVGISARHHELILQRLQDTKSVIHSRQFPFRFLNAHDA IDNLEAQLRNKA----------------------------------------LPF---PS NTQLMRR--------IMTRNAKSIRK---YPRYLCNLRRSQLRTAMMVP----------V LYEQLKREKLKIRKA--------------------------------------------- --------------------------------------------------RQWKCDTEML GRYRQALEVAVNLSVRHSLPPLPGRTLLVYMTDSRADLLCPKSNTQG------------- --------PPLNYVLLLIGMMMA-RAEQAEVLLCGRGTVKTAVLVAEDAILKTAITL-QA QVQEMEEVDE-------------------------------------------------- ------------------------------------------------------------ --------------CPLTTFE--------------------------------------- ----------------------------------------KYLLS--LAVQRVPVDRVVL FGEML-----RSPIVTVAKHIIWKHVNPKCLFVDVRV---RKPYPYSEFHPNHVTLSGCT DGILKFIAESGASRLLEHVDQMDRIFRIPPAPGKTQVLTLRPLEVDAPSPLAPVFQHGWR SIRLFISSTFRDMHGERDLLLRSMLPALQARAAPHRISLHAIDLRWGVTEEETRRNRQLE VCLGEVENSQLFLGILGSRYGYVPPSY-DLPDHPHFHWVQQYPPGRSVTELEVMQFLNRD RCAQPSAQALIYLRDSSFLSSVPDMWRPDFVSESEEAAQRISELKSYLSTRKEITCRGYS CEWGGTAAGRPYAGGLEEFGQLVLQDVWSVIQKLYLQPGAELEQPVSIPDDDLVQATFQE LRSPARPARLRLLQDTVRQLVLPHGKLSLVTGQSGQGKTTFLASLVSALRAPVGAKVAPL VFFHFSGARPDQSLALSLLRRLCSYL---HSKLHKVGALPR--THRGLVWELQQKLLPES AQTLQPGQTLVLIIDGADKLVDQNGQLISDWIPQSLPRWVHLVLSVSSDSGLGETLEQSQ GAYVVALGPLAPSARAQLVRDELALYGKRLDESPFNN----------------------- --------------QMQLLLVKRG-SGLPLYLRLVTDHLRLFTLYEQVSERLRTLPATVP LLLDLILSTLEQEHGHDVLPQTLATLEVTRSGLTEDQLHAVLSAWQILPKGTKSWEEAVA AGNSAEP-YPMGLFAYLVQSLCSLLGEGPLERPGARLCLRDGALKTAVKRRY--GKRRGL QHMAHVLIAA---QLWKTCNPDASGSFQSCLPEALGDLPFHLLHSGNHALLAKFLSSLPV VAAHLDLGLVPQLLEAHTLYASSVP-----EEDQKLPEADVAAFCTFLRQQAPVLSRYPL LLRQQAANQPADSPLCFQAPLLSQQWHRWPILRWLNKPQTVEGQQSSSLSLV-ISSTPTA VAISFNGQRAAVGTASGMVYLLDLRTWQEEKSVVSGCDGISSCAFLSDNALFLTAFDGLL ELWDMQRGCRVLQTKAHQYQITGCCLSPDQRLLATVCLGGCLKLWDTVRGQLSFQHTSAK PLNCTAFHPEGQAIAIGSWAGSVSFFQVDGLKATQDLGAPGASVRTLAFSATGQLVAVGR LDRTVELWAWQEGSRLAGFPAHCGFVSAVLFLHAQSQLLTAGEDGKVQVWSSSLGRPWGC LGSLRLSPALSVALSPDRDWVAVGYRKDGIKIYKIPAGSQQVLCQMVDVAVSALAWLSPK VLVSGAEDGTLQGWVLKNRVLHSLWLLPRYQRPVLGLAISQELLASASEDFTVRLWPKQL LTQWH-KTEDFPCGTELRGHEGPVSCCSFSMDGGSLATGGRDRSLLCWDVRTPQSPLLIR SFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPESGQQLGHFLGHQSAVSAVVAVEEH VVSVGRDGTLKVWDHGGVELTSIPAHSGPISHCAAALDPHPAGQPGSELLVVTVGLDGAP RLWHPLSVYHTHTLLGHSGSISAAAVSESSGLLLTASEDGSVRLWQVPKQAEGTNVPRSS AAITAIAWATDGSLAVSGNQAGELTLWQQAKAVATAQAPGRVSAVIWLSAYTFYVLSADE KISRWDVEFESDLTSTTFSLCLSQVLQEDLGVLTSMDLAPDGHSLILVKANMEILHLQPG NAPSIIGNRVGIHPILLSTHKEYGVFHLNTRYHLQCLCFLQQKESGEVKDHLDFLLNLEN PSGKSRKITQAKPESESSFLCASSDGELWRLAGCTFEGEWTTGNIWQKKVAAPEVQESGT DLSCTS-----MYNWVM-----ELDLKTQLHRKIHSDSVTALHVLPELLVTASKDRDVKL WDRPSMQLLGLFRCEGAVSCLEPCLRPDSTLQLAVGDTQGNVYFLSWE >M brandtii MEKLYGHVSAHPDILSLENR------------------------------CLATLPDVKI MEKPHGHVSSHPDILSLENRCLATLPDMRLMEKPHGHVSAHPDILSLENRCLATLSILKS PMSASSFLQCVQ---TSQLVQADLCSLDTSNHLLSEPP-TWRTQCFSEGPGPLTCPRALK SISATQGAQETALGHWSSSEEKKPGEKKWTEAQMPFYSLSLGEEEEV-EEMALKLTPGDS ESS--------------SEPTDQVLQEKKMALMSLLCSTVASKVNMKDEANPTKTALLEI CSELAPLEPEFILKASLYARQQLNIRDIANLTLAIAAFLPVCRPHLRRYFCAIVQLPSDW IQVAEFYQSLAEGEEDKLVALPACLRAAMTDKFTQFDEYQL--AKYNPRKHRAKRRPHRP PRPPKTERPFSETQKYLPKYLRFLKNEQEKFEESYNAVPERKKPPRFTLKKLVQRLHIQE PAQHVHALLGYRYPSNLQVFSRSRLPGPWDSGRAGKRMKLSRPETWERELSLRGNKASVW EELIDNGKLPFMAMLRNLCNLLRVGISAHHHELVLQRLQQA-----------VFVRGREP EE--------------------------------------------------LPF---PS NTQLMRR--------IMIRHSRNVKR-RVYQRQLQNLNRRKLRAAMMMP----------V FYEQLKREQLRVHRT--------------------------------------------- --------------------------------------------------RQWKYDREML ARYRQALETAVNLSVKHSLPPLPGRTLLVYLTDADADKICPKSNPEG------------- --------PPLNYVLLLMGMMIA-RAEHADLLLCGKGALKPAVIKAEDGILRTALEL-QA QVQELDGDYE-------------------------------------------------- ------------------------------------------------------------ --------------WSLHTLG--------------------------------------- ----------------------------------------KYLLS--LAAQRVPVDRVIV FGQAM-----NEKLINKAKQLFWQHVNSKCLFVGVLLR--RTCDTLQDLNPNDVTLSGCT DGILKFIAERGASRLLEHVGQMDKIFKIPPPPGKTGALAIRPLEENTPSPLAPISQPGWH SIRIFISSTFRDMHGERDLLLRSVLPALQARVAPHRISLHAIDLRWGITEEETRRNRQLE VCLGEVENSQLFVGILGSRYGYVPPTY-NLPDHPHFRWAQQYPSGRSVTEMEVMQFLDRG LRLQPSAQALIYFRDSSFLGSVPDAWKPDFTPESEEAVHRISELKSYLNKQKGVTCHRYP CEWGGVAAGLPYVGGLEEFGQLVLQDVWSMIQKLYLQPGAQLEQPVSIPDDDVVQATFQQ LQSPPSSARPRLLQDTVQQLLLHRGRLSLVTGQSGQGKTAFLASLVSALQVPGGAKVAPL VFFHFSGARPDQGLALTLLRRLCAYL---HRQLQEPSALPS--TYRGLVWELQQRLLPES AQSLQSGQSLVLIIDGADRLVDQHGQLISDWIPKTLPRWVHLVLSVSSDSSLGETLEQSQ GAHVVALGPLDPSARARLVREELALYGKRLDESPFNNQRRGCFAVGFVLDWRAGAGGLAV GRLSGTHVESSESPQMRLLLVKRG-SALPLYLRLVTDHLRLFTIYEQVSERLRTLPATVP LLLQHILGTLEKEHDPNILSQALATLGVTRSGLTVDQLHGVLSAWKVLPRGTKTWEEAVA AGNSGDP-YPMGPFAYLVQSLRSLLGEGPLERPGARLCLPAGPLRTVAKGRY--GKRLEL ESTAHILIAA---QLWKTCDPDASGTFRTCPPEALGDLPYHLLQSGNRGLLAKFLTSLHV VAAHLELGLLPRLLEAHALYASSVP-----EEEQQLPEADTAAFHTFLKQQAPLLSQYPL LLPQQAANQPLDSPLCRQASQLSQRWHLQRMLKWLNKPHTMGGQQSSSLSLT-VSSSPTA VAFSPSGQRAAVGTASGTVYLLDLSTWQEEKSLVSGCDGVSSCLFLSDNSLFLTAFDGLL ELWDLQHGCRVLQTKAHQYQITSCCLSPDRRLLATVCLGGCLKLWDTVHGQLASQHISPK PVNCVAFHPEGQVIAIGSWAGSCSFFQVDGLKVTKELGAPGASVCTLAFNVPGRVVAVGR LDRMVELWAWQEGALLAAFPAHHGFVAAALFLRAGCQLLTAGEDGKVQVWSGSLGRPRGC LGSLSLSPALSVALSPDGDQVAVGYRADGIRIYKISSGSQGAQCQALDVAVTALAWLSPE VLVSGAEDGSLQGWALQESSFESLWLMSRYQKPVLGLASSQAFLASASEDFTVRLWPRHL LTLPQ-KAEHFPCATELRGHTGPVNCCSFSTDGCRLATGGRDR----------------- ---------------------ISCSSDGSVGLWDPELGQQLGHFLGHQSAVSAVVAVEEH VVSVGRDGTLKVWDHQGVELTSIPAHSGPISHCAAALEPHAACQPGSELLVVTVGLDGLT RLWHPLLVFQTHTLLGHSGPINAAAVSEASGLLLTSSEDGSIRLWQVPKEVDEANIPRSP AAITAVAWAPDGSVAVSGNQAGELTLWQEAKAVATVQAPGRISALIWYSANTLVVVSADE KVSEWQVELRRDSTPRNFSLRLNRVLQEDLGFLTGVGLAPDGHSLILATADLKILHLKPG DAPSEIWHDYTEQPMMLSTHQDYGVFALQPM-APGVLSVLRQKESGEFEERLDFDLNLEN PSGTLISVTQAKPESESSYLCASSDGMLWNLAKCSFEGEWTTGNIWQKTVQMPETQTPET DPSVYSD----MASWPT-----TPCLKTRQRKKIHSGSVTALHVLPELLVTASKDRDVKL WERPSMQLLGLFRCEGAVSCLEPWLGPDSTLQLAVGDTQGNVYFLSWE >S franciscanus MLYFSNP----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------QQQFINAVSASLIGGPNFHERADGTRKNINRQ ATAIVDEDPEFILKVRIETYKELNIRTTANFLLALAAMTPDCRPFLRKYFSTSVALPSDW IDVAELYQVLMKQEVN-YGSLPSALRKAMIDRFPRFDQYQL--GKQLPYPARIIK-ISKG DKPAEEKPPSD-------------SDSDDEDDEDSDTDEEEMERLSFTLKQLIRKLHIKE PVSNHEIMKSSRYPEDMETFYQSRLSGTWDTERAGKRMKLPTPETWETQVSLKGNKAAVW EQLIDNKKLPFMAMLRNLRNMIAAGISEKHHKWVLYKLTDRGSVVYSKQFPFRFFSAYEV LQSMEYDLDKAKH-------------RSKSKPISSPLVMLFLYLISIHYFFIKHFSELPY DISILNRYRKALDSAVKIATSYNVKPIPGKTLLLCHVGESMERPCTSAKGLGKKRTV--S VLLMIKGIMYGIQIALNRSFTLGNLKDGLRNG------------------IIQRVLQKRN KKGVFRSMKCNKHR--------SKNKSISSPLVMLFLYLISIHYFFIKHFSELPYDISIL NRYRKALDSAVKIATSYNVKPIPGKTLLLCHVGESMERPCTSAKGLGKKRTVSVLLMIKG IKYWIQIVSQVLEVGILLGLMCKYSCENCDMLIFGGNSHRTVQLESGTILDNMASVLGQA QVGHYSGKCQHRSYYISIASPIKEC-------------IHWYKISIIHYALIKHFSELPY DISILNRYRKALDSAVKIATSYNVKPIPGKTLLLCHVGESMERPCTSAKGLGKKRTVSEL LIIKGIMCKYSCENCDMLIFGGNSHRTVQLESGTILDNMASVLGQAQVGHYSGSTQLDTY -----YILIAFSIALQSYIHYKIRIYFAKHYNIPSIHYSYKHSLPC-LLYIFSQLDNLVI LSNTSMQEGKEAEMISDFLTKYRRVVNENLLYVSVDLSGGRCSTSATPSHPNDIFIAGYS DQILRFIAERGDTGQVTHVQNIDKAYHLDDIKVRAAAVIVAAAVIKAAAIPARTNPRKHH EIRVFVSSTFRDFAAEREILIKKVFPELKAKCLDRGVFFYYVDLRWGITEKQTKHGSSIE ICLQEANRCDLFIGILGDRYGHIPNDYPDMSDNEDFNWLSSHPQSRSITELEM--HHKAL RHAEGSNKAFFYIRSSEFVKYVFDFFLFFF---------------------------SYP CHFGGVVEGKPVVVNLEEFGRRVINNVWNHIKQAYPEDGEILDE---VAHERAQHDMFLQ SQLATFTGRKNQIKQCLEAVKKAESGIIMVTGKQGCGKTALLASVVDTLQ----SKSSQP IVVHFVGAVPGSSHVSPLLKRLCNEL---IRRFGLQSQVPQ--EYRNLVSEF-PRFLEEA AAHVDSTNKLVIVIDGISGMDTAHQAHNLDWLPQNIPQNVLFIVSAVMSSPAHAAAVRRQ -ATMVELGPLDLMDKAEVVRRTLAAHHKTLDESPFNN----------------------- --------------QVNIILDPEGFSHLLNFANIYTKAILI------VSTRLKAMSHTIG TLLQEVLKRLEDDHGQDMINMALALLVSTRDGLYEEDLHHLLSLHQQMKDSKYSYKQVIG TALSPEVMLPQAVMSRLVRGIRSLLAPTG-EHRGRQQTQFLSWFYLLFEQCL----YDNT NNSSPFSFSGYFTHLAKT--KKSVSPWSPDYPHALSEMPYHLVQAGLFGELKNVLSDPFF IQAKCVSGLTASLLEDFQANTSTTSKAILREREKFLTNPLIASLRSFVSRQLHILTLCPG LLWQQAMNEP-DSSLVRHTVLESSGCREKSMVAWRNKREAADE---CSMTLTGFTDACLC VAIAPGDQVFAVGTKNCQLKLFEMDTGKELKSYIGHSDAVTSCCFVGRTRLPSASRSILL HL-DLSQPYRVNILKGHRGLVSGCISDPKGVNLASCSWDCRVLIWDGRSGKQTTDITEPR PISCAQFHPDGSLLVTGSADSTLKIWDAKSKKCVAILRGHHSSVRAVTYSPTGRHIASAS LDGAVKLWSADTGTQVGSLCGHSQPINHIAFSKNGRELVTVSNDHKTKVWSGNLGKQLAT FKGKDESASTQATFSANGEFVAMGYHSGQVKVIEVASKREVFTCQDRESRVRGIAWL--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ >S_purpuratus MSFLSNPLLAGSTSAKSKASGLT-----------------------------ATKRKASN GNQAQGSAPSKHPTPGMSLQSSSLLLGSSLLGGNSKFG------LGLQSSNLGTKSPLMA STGFNSKPQGSSGSGRSLLAGGSLLSSSSYLSLSSSLSSSTYGSSPAYGSSVLPNKQKTR SLSRSNSNQVDDSKTKKVKSQHHPEQTKVKEDSIIDPTLTTCELPDYDFSRQLPVTRTIV QEYVPSFEKLDMVNTLSTKPGEDILTELKQQFINAVSASLIGGPNFHERADDTRKNINRQ ATSIVDKDPEFILKVALYTRKELNIRTTANFLLALAAMTPDCRPFLRKYFSTSVALPSDW IDVAELYQTFHDKNIN-YGSLPSALRKAMIDRFPRFDQYQL--AKYNKEKKKKKKPVATT DKPAEEKPPSD-------------SDSDDDEDEDSDTDEEEMERLSFTLKQLIRKLHIKE PVDSVMCLLGKRYPEDMETFYASRLSGTWDTERAGKRMKLPTPETWETQVSLKGNKAAVW EQLIDNKKLPFMAMLRNLRNMIAAGISEKHHKWVLYKLTDRGSVVYSKQFPFRFFSAYEV LTSMEYDLKKADKLKEQLASGIKPPPRKQRGKKEDPIPKWKRAKMD------KKLSELPY DISILNRYRKALDSAVKIATSYNVKPIPGKTLLLCHVGKSMERPCTSAKGLGKKRTV--T KYNKEKKKKKKPVATTDKPAEEKPPSDSESDDDKDEDSDTDEEEMERLSFTLKQLIRKLH IKEPVDSVMCLLGKRYGWMIQTGKKKDLVTPEIPRALPAPQ------QTRSELPYDISIL NRYRKALDSAVKIATSYNVKPIPGKTLLLCHVGKSMERPCTSAKGLGKKRTKEIWRVANG ELLVFYAMDNVLEVGVLLGLMCKYSCENCDMLIFGGNSHRTVELESGTILDNMASVLGQA QVGHYTGVHDNK--LKEQLASGIKPPPRKQRGKKEDPIPKWKRAK-----MDKKLSELPY DISILNRYRKALDSAVKIATSYNVKPIPGKTLLLCHVGKSMERPCTSAKGLGKKRTVLEV GVLLGLMCKYSCENCDMLIFGGNSHRTVELESGTILDNMASVLGQAQVMMTQEEQGQGLD PTILGEILRDRDEVSQQSNAVPGLSFLQDIMPQEKEGQGLDPTILGEMLRDRVELDNLVI LSNSAMQEGKEADMIKGFLTKYRRVVNENLLYVSVDLSGGRCSLSATPSHPNDIYIAGYS DQILRFIAERGDTGQVTHVQNIDKAYNLDDIKIQTGKKKDLVTPEIPRALPAPQQTRRHH TVRVFISSTFRDMHGERDLLTRFVFPELRAKVRTRFVNLYEVDLRWGVSEEQTKHSSSVE VCLQEANRCDLFIGILGDRYGYVPNDYPDLSDNEDFNWLSTHPKSRSITELEM--YHKAL RHSEGSTKAFFFIRSSEFVKHVPNKLRSQFEDESSQSKEKLASLKETIRTSGCEVFDGYP CHFGGVVEGKPVVVNLEEFGRCVINNVWNHIKQAYPEDGEILDE---VAHERAQHDMFLQ SQLATFTGRKTQVKQCLEAVKKAETGIIMVTGKQGCGKTALMASVVDTLQ----SKSSQP IIVHFVGAVPGSSHVSPLLKRLCNEL---VRRFGLQSQVPQ--EYKNLVSEF-PRFLEEA AGHVDSTNKLVIVIDGISGMDAAHQAHNLDWLPQNIPQNVLFIVSAVMSSPAHAAVVRRQ -ATMVELGPLDLMDKAEVVRRTLAAHHKKLDESPFNN----------------------- --------------QMKLLVSKRE-ANLPLFLKLACEELRVFGVFEEVSTRLKAMSHTIG TLLQEVLKRLEDDHGLDMINMALALLVSTRDGLYEEDLHYLLSLHQQMKDSKYTYKQVIG TALGPEVMLPQAVMSRLVRGIRSLLAPTG-EHSDHRLRVSHGQISQAIIQRYMKGAASEL QIRTHALLAGYFTHLSRT--KNAVSPWSPHYPHALSEMPYHLVQAGLFGELKNVLSDPFY VQAKCVSGLTASLLEDFQANTSTTSKAILREREKFLTNPLIASLRSFVSRHLHILTLCPG LLWQQAMNEA-DSSLVRHTVLESAGCREKGIVAWRNKRETADE---CSMTLTGFTDAVLC VAIAPGDQVFAVGTKNCQLKLFEMDTGKELKSYIGHSDAVTSCCFVGRTRLVSASRDKTL SLWDVDQGFRVNILKGHRGLVSGCISDPKGVNLASCGWDCRVLIWDGRSGKQTTDITEPR PISCLSYHPEGKLLVTGSWDSTLKIWDTFNKKRVAILRGHHSSVRAVTYSPTGRHIASAS LDGAVKLWSADTGTQVGSLCGHSQPINHIAFSKNGRELVTVSNDHKTKIWSGNLGKQLAT FKGKDESASTQAAFSADGEFVAMGYHSGEVKVIEVASKREVVTCPDRESRVKGIAWY--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ >L variegatus ------------------------------------------------------------ -----MFMFVVLESYEIAMKC--------------------------------------- -----SLLQFLI------------------------------------------------ ------------------------------------------------------------ ---------------------------QQQQFINAVSASLIGGPNFHERGDSTRKNINRQ ATSIINEDPEFIYQVALYTRKELNIRTTANFLLALAAMTPECRPFLRKYFSSSIALPSDW IDVAELYQTMHDKNIN-YGSLPSALRKAMIDRFPRFDQYQLGAAKY-LKLKQAIKHAQKC KKPAECQDLPD--------------RRDIGDSENADYLSEEMERLSFTLKQLIRKLHIND PVDSVMCLMGYRYPEDMESFYQSRLPGTWDPERAGKRMKLPTPETWETQVSLKGNKAPVW EQLIDKKKAPFMAMLRNLRNMIAAGISEKHHKWVLYKLTDRGSVVNSKQFPFRFFSAYEV LQSMERELEKARY------YSIRPIISKQAQLSISPSIGQSKSQEYISSL--LPSSELPY DITILNRYRKALDTAVKIATSYNVKPIPGKTLLLCNVGSYMDTPCSSAKGLGKKYPLFAA KYQAIKYHIYQILKLLSIARECLALS---RIDKMSHAIPNLISYYFRLSFTLKQLIRKLH INDPVDSVMCLLGK---------RCYAYYNWYLLLFSPQPMISHPYLPS-SELPYDITIL NRYRKALDTAVKIATSYNVKPIPGKTLLLCNVGSYMDTPCSSAKGLGKKRAIPLSQYASI DSYSYY-IPPIIYVGILLGLMCKYSCEHCDMRIFASSAHSAVELESGTILDNMTSVLSQA RVSHHRVILNSTTYFPLSFIICMYCFCHNHCGA----LLEYIFLILVCYGI----SELPY DITILNRYRKALDTAVKIATSYNVKPIPGKTLLLCNVGSYMDTPCSSAKGLGKKRCDCVV GILLGLMCKYSCEHCDMRIFASSAHSAVELESGTILDNMTSVLSQARVSHTVILNGSLGF PK---KLLIALNLLLKNSSGFCGSFFFFISCDIFASSF--KFLSLCLLFIILVQLDNLVI LSTSSAHGGKETEMISEFLSKYRRVVNENMLYVNVDLSGGRCRTSDTPSHPNDIFIAGYS DQILRFIAERGDTGQVTHVQNIDKAYNLTDCKVFFINKLLEPNVQFAEVKFVNKKTKEKY VIRVFVSSTFRDFEEERELIIKKVFPELNRLCLDRGYFFTYVDLRWGITEEQTKSGRTIE ICLREVSRSDMIIGIFGQVYWYLPNDYPDMSDIEDFDWLSAHPKSRSITELEM--YHKAL RNWGTSNNAFFFIRNSEIIRNVPNKLRSQFIDENTQRKERLASLKDTIRTSGCEVFDGYP CHFGGVVGGKPVVVNLEEFGRRVINNIWNYIKHAYPEDGEILDE---VVHERAQHDMFLQ SQLATFTGRKNQFKQCLDIIKKAETGLLMVTGKQGCGKTALLVR----YDKGDGRFEAGS LSLGRAIIRP------------QNTLADKRSRIKKEFFLKAIDDARNLVSEF-PRFLEEA AKHVDSANKLVIVIDGVSGMNTAHQAHNLDWLPQNIPQNVVFILSGVASSPAHAAAVRRQ -ATVIELGPLDLMDKAEMVRRTLAAHHKTLDESPFNN----------------------- --------------QMKLLVSKRE-ANLPLFLKLACEELRVIGVIE-VSTRLKAMSHTIG TLLQEVLKRLEDDHGQDMIIVALALLVSTRDGLTPAS-SCLLSLDRQLNQSKYTYNQVIR TGLGPEVMLPQAEMSRLVRGIKSLLAPTG-EHSDHRLRVSHGQISQAIVQRYMKGAASEL QIRTHALLAGYFNHLSRT--KNVASPWCTDYPHALTEMPYHLVQAGLFAELKNVLSDPFF IQAKCCSGLTASLLEDKQANTSTTSKAILREREKFLTNPLITGLRSFISRHLHILTLCPG LLWQQAMNEP-NKSLVREAMLESAGSGEKGMVAWRNKRETADE---CAMTLTGFTDVCLC VAIAPGAQVFAVGTKNCQLKLYEMETGQELKSFIGHSDAVTSCCFVGKSRLVSASRDKTL SLWDVEQGFRVNTLKGHRGLVSGCISDSKGVNLASCGWDCRVLIWDGRSGKQTSDITEPR PISCLSYHPDGKLLVTGSWDATLKIWDTFNKKRVAILRGHCSSIRAVTYSPTGRHIASAS LDGAVKLWSADTGTQVSSLCGHSQPINHIAFSQNGRELVTVSNDHKTKVWSGNLGKQLAT FKGKDQSASTQATFSPYGEYVAMGYHSGEVKVIEVASKREVFASVLRESRVKGIAWG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------ >M musculus MEKLCGHVPGHSDILSLKNRCLTMLPDLQPLEKIHGHRSVHSDILSLENQCLTMLSDLQP TERIDGHISVHPDILSLENRCLTMLPDLQPLEKLCGYMSSNPDVLSLENRCLATLPTVKS TALTSPLLQGLH---ISHTAQADLHSLKTSNCLLPELP-TKKTPCFSEELDLPPGPRALK SMSATAQVQEVALGQWCVSKEKEFQEEESTEVPMPLYSLSL-EEEEV-EAPVLKLTSGDS GFH--------------PETTDQVLQEKKMALLTLLCSALASNVNVKDASDLTRASILEV CSALASLEPEFILKASLYARQQLNLRDIANTVLAVAALLPACRPHVRRYYSAIVHLPSDW IQVAEFYQSLAEGDEKKLVSLPACLRAAMTDKFAEFDEYQL--AKYNPRKHRSKRRSRQP PRPQKTERPFSERGKCFPKSLWPLKNEQITFEAAYNAMPEKNRLPRFTLKKLVEHLHIHK PAQHVQALLGYRYPATLELFSRSHLPGPWESSRAGQRMKLRRPETWERELSLRGNKASVW EELIDNGKLPFMAMLRNLCNLLRTGISARHHELILQRLQHEKSVVHSRQFPFRFLNAHDS IDKLEAQLRSKA----------------------------------------SPF---PS NTTLMKR--------IMIRNSKKNRR-PASRRHLCTLTRRQLRAAMTIP----------V MYEQLKREKLRLHKA--------------------------------------------- --------------------------------------------------RQWNCDVELL ERYRQALETAVNLSVKHNLSPMPGRTLLVYLTDANADRLCPKSHSQG------------- --------PPLNYVLLLIGMMVA-RAEQVTVCLCGGGFVKTPVLTADEGILKTAIKL-QA QVQELEGNDE-------------------------------------------------- ------------------------------------------------------------ --------------WPLDTFG--------------------------------------- ----------------------------------------KYLLS--LAVQRTPIDRVIL FGQRM-----DTELLKVAKQIIWQHVNSKCLFVGVLLQ--KTQYISPNLNPNDVTLSGCT DGILKFIAEHGASRLLEHVGQLDKLFKIPPPPGKTQAPSLRPLEENIPGPLGPISQHGWC NIRLFISSTFRDMHGERDLLMRSVLPALQARVFPHRISLHAIDLRWGITEEETRRNRQLE VCLGEVENSQLFVGILGSRYGYIPPSY-DLPDHPHFHWTHEYPSGRSVTEMEVMQFLNRG QRSQPSAQALIYFRDPDFLSSVPDAWKPDFISESEEAAHRVSELKRYLHEQKEVTCRSYS CEWGGVAAGRPYTGGLEEFGQLVLQDVWSMIQKQHLQPGAQLEQPTSISEDDLIQTSFQQ LKTPTSPARPRLLQDTVQQLLLPHGRLSLVTGQAGQGKTAFLASLVSALKVPDQPNEPPF VFFHFAAARPDQCLALNLLRRLCTHL---RQKLGELSALPS--TYRGLVWELQQKLLLKF AQSLQPAQTLVLIIDGADKLVDRNGQLISDWIPKSLPRRVHLVLSVSSDSGLGETLQQSQ GAYVVALGSLVPSSRAQLVREELALYGKRLEESPFNN----------------------- --------------QMRLLLAKQG-SSLPLYLHLVTDYLRLFTLYEQVSERLRTLPATLP LLLQHILSTLEQEHGHDVLPQALTALEVTRSGLTVDQLHAILSTWLILPKETKSWEEVLA ASHSGNP-FPLCPFAYLVQSLRSLLGEGPVERPGARLCLSDGPLRTTIKRRY--GKRLGL EKTAHVLIAA---HLWKTCDPDASGTFRSCPPEALKDLPYHLLQSGNHGLLAEFLTNLHV VAAYLEVGLVPDLLEAHVLYASSKP-----EANQKLPAADVAVFHTFLRQQASLLTQYPL LLLQQAASQPEESPVCCQAPLLTQRWHDQFTLKWINKPQTLKGQ--QSLSLT-MSSSPTA VAFSPNGQRAAVGTASGTIYLLNLKTWQEEKALVSGCDGISSFAFLSDTALFLTTFDGHL ELWDLQHGCWVFQTKAHQYQITGCCLSPDCRLLATVCLGGYLKLWDTVRGQLAFQYTHSK SLNCVAFHPEGQVVATGSWAGSITFFQADGLKVTKELGAPGPSVCSLAFNKPGKIVAVGR IDGTVELWAWQEGARLAAFPAQCGCVSAVLFLHAGDRFLTAGEDGKAQLWSGFLGRPRGC LGSLPLSPALSVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSALVWLSPS VLVSGAEDGSLHGWMFKGDSLHSLWLLSRYQKPVLGLAASRELMAAASEDFTVRLWPRQL LTQPHVHAVELPCCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWDMKIAQAPLLIH TFSSCHRDWITGCAWTKDNILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVSAVVAVEEH IVSVSRDGTLKVWDHQGVELTSIPAHSGPISQCAAALEPRPGGQPGSELLVVTVGLDGAT KLWHPLLVCQIRTLQGHSGPVTAAAASEASGLLLT-SDDSSVQLWQIPKEADDSYKPRSS VAITAVAWAPDGSMVVSGNEAGELTLWQQAKAVATAQAPGRVSHLIWYSANSFFVLSANE NVSEWQVGLRKGSTSTSSSLHLKRVLQEDWGVLTGLGLAPDGQSLILMKEDVELLEMKPG SIPSSICRRYGVHSSILCTSKEYGLFYLQQG-DSGLLSILEQKESGEFEEILDFNLNLNN PNGSPVSITQAKPESESSLLCATSDGMLWNLSECTPEGEWIVDNIWQKKAKKPKTQTLGT ELSPHSELDFSMDCWID-----PTHLKAQQCKKIHLGSVTALHVLPGLLVTASKDRDVKL WERPSMQLLGLFRCEGPVSCLEPWMEPSSPLQLAVGDTQGNLYFLSWE TERT >H sapiens MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPW DARPP-PAAPSFRQVSCLKELVARVLQ---RLCE--RGAKNVLAFGFALLDGARGGPPEA FTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCA-----YQ VCGPPLYQLGAATQA--------RPP-PHASGPRRRLGCERAWNHSVREAGVPLGLPAPG ARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAE EATS-LEGALSGTRHSHPSVGRQH------------HAGPPSTSR--PPRPWD----TPC ----PPVYAETKHFLYS--SGDKEQLR-----PSFLLSSLRPSLTGARRLVETIFLGSRP WMPGTP--RRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAR E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------KPQGSVAAPEEEDTDPRRLVQL LRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWK MSVRDCAWLRRSPGVGCVPAAEHRLREE-ILAKFLHWLMSVYVVELLRSFFYVTETTFQK NRLFF--YRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPD GLRPIVNMDYVVGA-RTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIH RAWRTFVLRVRAQD------PPPELYFVKVDVTGAYDTIPQDRLTEVIASIIK---PQNT YCVRRYAVVQKAAHGHV--RKAFKSHVSTLTDLQPYMRQFVAHLQ--ETSPLRDAVVIEQ SSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSL---------- ---CYGDMENKLFAGIRRDGL-------LLRLVDDFLLVTPHLTHAKTFLS--------- ------------------------------------------------------YARTSI RASLTFNRGFKAGRN-MRRKLFGVLRLKCHSLFLD-LQVNSLQTVCTNIYKILLLQAYRF HACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQW LCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD >H_glaber MPRAPRCRAVRALLRRRYYEVLPLAAFARRLGPEGARLLRRGDPAAFRALVAQCMVCVPW DARPMYPGTPSFRQVSSLKELVARVVQ---RLCE--RGARNVLTFGFGLLNEARGGPPLA FTTNVCHFRPNTVTDSLRGSGAWGLLLSRLGDDVLVHLLSRCALYQLVAPSCA-----YQ VCGQPLHELGGLTASQR------RAPHP-------------------------------- ---RPVLGSLRRAPSCSAGASPTP-PKKPRHGLGNG-----------------EPRVVSP GAAS-LEGEPSRSRDSRSTTG--------------------------------------- ----PREATETKRFLYSRVGGGAERLR-----ASFVLSALPPNMTGARRLVEALFLGPPP VRPGPPYRSRARRLAPRYWRMRPLFRELLANHARCPYGALLRVHCPLRVSVDP------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------EGDAGAQRLAQL LRAHCSSWQVYAFLRACLHLLVPAGLWGSRRNERRFLRCTKRFLSLGKHGKLSLRELTWK VKVRDCAWLRASPGDACVPAAEHRLQER-LLATFLFWLLDTYVVELLRSFFYVTETTFQK NRLFF--YRRSLWRELQSIGVRQHFERVQLRELSAAELRQHQEARLALPTSRLRFVPRLS GLRPIVNMDCMVGTGATLGERKQAQQCTPRIRTLFSVLNYERARWPKLLGASVLGLDDTY RAWRAFVLRMRAQD------PAPRLYFVKADVSGAYDALPQDKVAEVVASVLR--PWENT YCVRRYAVVQRAARGHT--RRAFRRHVSTLPDLQPYMSRFVEHLQ--EACRLRDAVVIEQ SCSLNETGCSLFDFFLRFLRGSILRIGGRCYVQGRGIPQGSILSTLLCSL---------- ---CYGDMENMLFTRVQQDGV-------LLRLVDDFLLVTPHLAQARAFLGTLVRGIPEY GCTLNLQKTLVNFPVEDGVLGGPAPLQLPTHCLFPWCGLLLDTRTLEVRCNYASYARTSI RASLTFDRGIRAGWS-MRRKLLAILRLKCHGLFLD-LQVNSLRTVLINIYKIFLLQAYRF HACVLQLPFHQPVRKNAPFFLRIISDSASRCYSILKAKNAGVSLGTKGATGPFPSEAARW LCHQAFLLKLGHHRATYKCLLGPLRTAQTQLRGKLPKVTMAALEAAADPALTMDFKTILD >S franciscanus ----------MDILERFYPRVSRLEDFLKDLN-GCPPLYIPKDKAGYRAFLQSTLVGIP- SCHMNYQGPLDYTQHSDHMEVINRVLLLSDQMCQ--HRVRS------------GGRVTQL FVKQKRKIMKRRLGMP---VVDLFLVFHKVSCELDQTICREGFISQASSPSTYEPRQMSR SIGTPLSMLISSLPI--------NTPSPAKTSTIEQGSKKRRKSFQLKDADKGGKVDECD GKGRNVQGKRKRDEDVGCNQEDAN-VAKFRRGGFMV-----------------EPYLVCS YQFKFLYFHLFKKKNYFLSLGTAPAHL-------SPSDQGSSITQDFPQSAWVSILMCRV ----LKRSNLLIYMLYNHIRYHASKIKYYCRYPVLIK---EKNIIFFRKL-KLNSILNHQ CPLNLP--QDSPPSDHTDTSHQECSMEALGKRSHTKKSSLSPPCSSECASREKSLAELRE E----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SMLQG ISFH----------------------FSGRNFKFEYSKSSVSIVDNTEDITSSTFYYTSV LQAEDCAWCQLEKFKGRDPPFTSLVKQRQLVTVLFFFGGDGGRC--LCAPLHLNKSKMGS SILSFILF--------------------------QNDVRKLVSAGLTLGFSRLRFVPKTK GLRPITRMG------KSVIEEKKVSQ---------------------------------- ----------SPND------PVKPAF-------------KNHLYRKTTYSLLSYQDKPEE YQIQRYVTVTRAASASTGLQKTSRRHVTT--ELSSFHRQLIKMAQ---HGEIKNAIIINQ VYDYNLITFVLLHNYFEHIICHYFQSGRKHYWRQDGISQGSILSSLLCSF---------- ---FYAHLERCYLSDIDQEGVCNHSLVRLLSFLCSFFHASLRKKKPQ--------GVKQY GCSANPSKTLANFDFMYD-----GQLVPRSAEWFPWCGIVFNTQTLNISNDYTKYNN--- -RLLVRGRGLNPRPPGCEGGRSTDANTPVLWLYCTIFQINSFLTIVINVYHLLLLLAHRF HSYYHCLASYIKQNTPPLQFYSKTEDYAIYLYYIAFYICIYPSHHIHHAMYFIEIFIFR- IGLKAFDTKLSKHKGLYHPLIKLVRKHRRKAALKMVIILISQLRCQ-------------- >S purpuratus ----------MDILERFFPRVSCLEDFLRDLN-GCPPLCIPRDKAGYRAFLQSTLVGIP- SCHISYQGPLDYTQHSDHMEVINRVLL---RLQHQGKGGKNVLLNGFTSWRSEGDYAGIP PSINV----PNNNSNQLR-IPFWSKLLSRIGDELIMHILENLSIFAAAPPSCY-----IQ LTGTPLSMMISSLPT--------NTPSPAKTSTVEQRLKQRRRSFQSKDAAKGGKVDRCD GDRRNAQGKRKRDRDGGCNQEDAN-VAKFRKGEQGMRQPTQTKEAENRKEIKKDPKVLES MITGLERSYYILNACYSRTVGRTLLKHDLVSKLPASNSGAQMLTQHIFNSPGKSDKTASH ----DGKGRSEIGIQGDDKGRKTKKLQRTCRRLIKVQALLKTFLTQHRKL-KLNSILNRQ CPLNPP--QDGPPSDHTNTSHQEGSTETQGQRSHTKKTSLPPPCAGEGASCEKSLAELRE ESMLEGYSPKVFQRKRPKQSVLNNTQVSSVEQFDGTRMEESVIQVDDRRGGIEQKRKDDG RKGSTKKVGEGIRDGLRDKVGLGETEERVGNVRRKKIGEMVKSTKAQSTTDERKIDEKNG HSKSHPGSTKDFDVSQSLSARMEMDENATSSTSGDALQETDSIPSQPHMRLRRKTNTETE TRAGLPSGEVTVDNDDDDDTLTVSGKILSQPDKRLRGKTNMRAKRNTLSIGDGVLRESQP DRKTQRRTKTKTGRQLPSDTAAPSGHPKRDETPDSMQFQLKRKMKKTTDTKALPNDAATL IKMKTDPWQVCLFLRQVLLKVVPDELWGSVHNRNVFLKGVKKFVQLGRFERLSLRELTEE IRAEDCNWCQLEKFRGRDPPFTSLVKQRQLVTDFFHWLMIGYTVPLIMMCFYVTETSSSR NQLVF--YRKPVWPLLEKIGIQYYVAHGIMKPMKENDVKKLVSAGLTLGFSRLRFVPKTK GLRPITRMG------KSVIEEKKGLSVRLLLQDLFDVLTYHKINQPSVMGSSLLGIDGIY HKVLKFMKDRKERK------DTRPLYFVKIDIEKCYDSIKRSKLLQIISTLLQGHDKPDE YRLQRYVTVTRAASASTGLQKRSHRHVTT--ELSSFHRQLIQMAQ---HGKIKNAIIINQ VHTVKVTPKELLQRLKQHVMADVVKSGRKYYWRQDGISQGSILSSLLCSF---------- ---FYAHLERCYLSDIDQEGL-------MMRLIDDFLLITPHHDKAQRFLQLLLSGVKQY GCSANPNKTLANFDFMHD-----GQLVPRSKELFPWCGIVFKTQTLNISNDYTKYNNVSI RYTLTICTGRDTSLHLMRIKLTWSLKAKNVSIFMD-PLINSFLTIVINVYHLLLLLAHRF HSYYYCLASYIKQNTPPLQFYNIWASCVRIFHACTVSKLRKDDQGERETTFPLTINTVNW IGLKAFDTKLGKHKGLYHPLIKLVRKHRQKAALKMGKAMLEVLEEMTNPALPDDFMKMRR >L variegatus ----------MDILERIYPKVSCLEDFLRGLD-GCPPLYLPKDKAG-------------- ------------------------------------------------------------ -------------------VSFLFLSMFRIGDELMMHILENLSIFAAAPPSCY-----IQ LTGEKIFPIIQICK---------GYLDYYYITFVRHLILSKLTVFCLFVLGIKIK----- -ERKNVAGGNDTDNAAILTIKNQNWCASPIDRPTTVNHPVLSRVLNLMDLALMDKRVKRG LSFG-SQNLLWRQNDKHIRWNNHNIDHG-----NASSSDFTFKSINIVPKCDVTMSQQTC WFTVAAAGLSIHIILYN--------LQKWCV-LSLVVTIILRVIKGCRRI-QIYFSEQRR S-------SLIAHQAHLYSRIKHLAIHIL--HIKSLKRAIYPT----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------AKQHQPHYICNP AAIK--PWQLTSSISYFILSFF-------------FLYEIVNQESQHQCYTLPL------ IQAEDCEWAQLEKFKGHDPPFTSVVKQRQLVMDFFHWLMVGYTIPLIMVIFYVLETASSR NQLIF--YRTPVWILLEKIGIQQIPFYSYILMLEKGEVMKRISTGQTLGISRLRFIPKTK SLRPITRMG------KSVISEKKGSLEEKEIDAKICL---------QVIAQLACSLFDCI SNDFCFEYDAEKPDLLIDQHNSRPLYFVKVDIEKCYDSIKHRKLLQIISSLLQ-MDKPDE YFIQRYVTVTKAASTSSGLQKTTHRHVTT--EMSIFHRQLIEMAK---RGQMKNAIIINQ VLAPKAA--------FEPICSTKFCINAR-------------LSTIKCEFRQRLFCCSIQ ISSAFGLQINILCTEISLDIF----LILMMRLIDDFLLVTPHLDKAQRFLHLLISGVEQY GCSANPTKTLVNFDFMFN-----GQMVPRSTELFPWCGIVFNTQTLNISNDYTKYDNIS- KYIYLIIDGFCEKAN-IDKFRHFTVSKSCA---CADFEINSFRTIVVNVYHLLLLLGYRF HSYYHCLANCIQKNTRPLQFSSMWASCVRIFHAYIISKLRRDNREDAETAFPLTINTVNW IGLKAFETKLSQHRGSYHPIIKLVTTHRRKAAQKMFLCQVR-INIYSQKRYSLAAPNIKY >M_musculus MTRAPRCPAVRSLLRSRYREVWPLATFVRRLGPEGRRLVQPGDPKIYRTLVAQCLVCMHW GSQPP-PADLSFHQVSSLKELVARVVQ---RLCE--RNERNVLAFGFELLNEARGGPPMA FTSSVRSYLPNTVIETLRVSGAWMLLLSRVGDDLLVYLLAHCALYLLVPPSCA-----YQ VCGSPLYQICATTDIWPSVSASYRPTRPVGRNFTNLRFLQQIKSSSRQEAPKPLALPSRG TKRHLSLTSTSVPSAKKARCYPVPRVEEGPHRQVLPTPSGKSWVP--------SPARSPE VPTA-EKDLSSKGKVSDLSLSGSV----------CCKHKPSSTSLLSPPRQN-----AFQ ----LRPFIETRHFLYSR-GDGQERLN-----PSFLLSNLQPNLTGARRLVEIIFLGSRP RTSGPL--CRTHRLSRRYWQMRPLFQQLLVNHAECQYVRLLRSHCRFRTANQQ------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------VTDALNTSPPHLMDL LRLHSSPWQVYGFLRACLCKVVSASLWGTRHNERRFFKNLKKFISLGKYGKLSLQELMWK MKVEDCHWLRSSPGKDRVPAAEHRLRER-ILATFLFWLMDTYVVQLLRSFFYITESTFQK NRLFF--YRKSVWSKLQSIGVRQHLERVRLRELSQEEVRHHQDTWLAMPICRLRFIPKPN GLRPIVNMSYSMGT-RALGRRKQAQHFTQRLKTLFSMLNYERTKHPHLMGSSVLGMNDIY RTWRAFVLRVRALD------QTPRMYFVKADVTGAYDAIPQGKLVEVVANMIR--HSEST YCIRQYAVVRRDSQGQV--HKSFRRQVTTLSDLQPYMGQFLKHLQDSDASALRNSVVIEQ SISMNESSSSLFDFFLHFLRHSVVKIGDRCYTQCQGIPQGSSLSTLLCSL---------- ---CFGDMENKLFAEVQRDGL-------LLRFVDDFLLVTPHLDQAKTFLSTLVHGVPEY GCMINLQKTVVNFPVEPGTLGGAAPYQLPAHCLFPWCGLLLDTQTLEVFCDYSGYAQTSI KTSLTFQSVFKAGKT-MRNKLLSVLRLKCHGLFLD-LQVNSLQTVCINIYKIFLLQAYRF HACVIQLPFDQRVRKNLTFFLGIISSQASCCYAILKVKNPGMTL---KASGSFPPEAAHW LCYQAFLLKLAAHSVIYKCLLGPLRTAQKLLCRKLPEATMTILKAAADPALSTDFQTILD >SIG ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------+---------------------------- ------------------------------------------------------------ --------------------------+--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------+-------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------+--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------+-------------------------------------------------- -------------------------+---------------------------------- VLDLR >H sapiens ----------MGTSALWALWLLLALCWAPRESGAT---------GTGRKAKCEPSQFQCT NGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNN-G------QCVPSRWKCDG- -DPDCEDGS-----DESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGEN-DCDSGEDE ENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCS---TS SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD CKDGSDEVNCPSRT---CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG PGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKE-CHINECLVNNGGCSHICKDLVIGYE CDCAAGFELID----RKTCGDIDECQN-PGICSQICINLKGGYKCECSRGYQMDLAT--G VCKAVGK--EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD---ADIAAQKLFWAD LSQKAIFSASIDDKVGRHVKMIDN-VYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK RKFLFNSDLREPASIAVDPLS-GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGI TLDLIKSRLYWLDSKLHML-SSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGEN EAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQ INDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINVTT AVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEED LSIDIGRHSASVGHTYPAISVVSTDDDLA >H_glaber ----------MGTSARWALWLLLALSWEPRESSAT---------GTGRKAKCDPSQFQCT NGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNN-G------QCVPNRWQCDG- -DPDCEDGS-----DESPEQCHMRTCRINEISCGARSTQCIPVSWRCDGES-DCDSGEDE ENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCNDGSDELDCAPPTCSAHEFQCS---TS SCIPLSWVCDDDADCSDQSDESLEQCGRQPVMHTKCPASEIQCGSGECIHKKWRCDGDPD CKDGSDEVNCPSRT---CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNANQCLG PGKFKCRSGECIDMIKVCNQEQDCRDWSDEPLKE-CHVNECLINNGGCSHICKDLVIGYE CDCAAGFELID----RKTCGDIDECQN-PGICSQICINLKGGYKCECSRGYQMDLAT--G VCKAVGK--EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD---ADIAAQKLFWAD LSQKAIFSASIDDKVGRHVKMIDN-VYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK RKFLFNSDLREPASIAVDPLS-GFVYWSDWGEPAKIEKAGMNGFDRRPLVTVDIQWPNGI TLDLIKSRLYWLDSKLHML-SSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGEN EAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCDEDMENGGCEYLCLPAPQ INEHSPKYTCSCPSGYSLEENGRQCQSTATTVAYRESKDTNTTEILPTSGLVLGGINVTT AIPEVSVPPQGTSAAWAILPLLLLAMAAVGGYLMWRNWQNKNMKSMNFDNPVYLKTTEED LSIDIGRHSASVGHTYPAISVVSTDDDLA >M_brandtii MWASEPLNNGAASPARR---SVREEAEGPETCAAAPARSVDFRDGVGRKAKCDPSQFQCT NGRCITLLWKCDGDEDCADGSDEKNCEKKTCAESDFVCNN-G------QCIPSRWQCDG- -DPDCEDGS-----DDSPEQCHMRTCRTNEISCGAHSTQCIPESWRCDGEN-DCDSGEDE ENCGNITCSSDDFTCSSGRCISRNFVCNGQDDCNDGSDELNCAPPSCGAHEFQCS---AS SCIPLSWVCDDDADCSDQSDESLEQCGRQPVMHTKCPASEIQCGSGECIHKKWRCDGDPD CRDGSDEVNCPSRT---CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG PGKFKCRSGECIDIIKVCNQEQDCRDWSDEPLKE-CHVNECLVNNGGCSHICRDLVIGYE CDCAAGFELID----RKTCGDIDECQN-PGICSQICINLKGGYKCECSRGYQMDLAT--G VCKAVGK--EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD---ADIAAQKLFWAD LSQKAIFSASLDDKVGRHVKMIDN-VYNPAAIAVDWVYKTLYWTDAASKTISVATLDGTK RKLLFNSDLREPASIAVDPLS-GFVYWSDWGEPAKIEKAGMNGFDRRPLVAVDIQWPNGI TLDLIKNRLYWLDSKLHML-SSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGEN EAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQ INDHSPKYTCSCPNGFNLRANGRECQSTATTMTYSETKDTNTTEISPTSGLVPGGINVTT AVSEVSVPPKGTSAAWAILPLLLLAMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEED LSIDIGRHSASVGHTYPAISIVSTDDDLA >S franciscanus --------------------LLLSLLLSSHCITLILL------FYSGSAILCGEYQFRCQ NGHCIPSYWQCDNYDDCGDNSDEQSCPKMYMYSLEYSYS---------YIIHCRIRIRMI YYIPCPNPSL----RIATSHAETLTCSPSQFSCG-PGKNCIPLTWRCDRDV-DCPSGADE HNCDALTCASNQFTCNNKKCVTTRWVCDGDNDCGDGSDEINCPSLTCAPDEFECTGTNET TCIPNRWKCDGEIDCRDGSDESSTHCSTATTP---CSAGQFQCASGRCIHAAWKCDGERD CGDGSDEESCCLVTPSPCAASEYRCDDGVCIPGDVECDGTQQCADGSDEANCNAPAECNP ITHFRCSNSTCLPMVRVCNGIPECPNNEDEPGQEICGKNECLTNNGGCSHTCMDLAIGHV CTCNAGYALVN----ETQCVDINECKTTLGICSQRCYNLPGSYKCDCDENYTLEHVNDRG HCKANPEFGTPKLLIANRHDIRIFDLRTSSEDYIRRSLHSAVAVE---FDSASNTVFWTD VGLEVVAKFGKQILDFFEMSYISD-VLLPDGVAVDWITRNLYWTDSGRDTIEVSRLDGSS RTVLIDEDLDEPRAIALDPEG-G-MFWSDWGL-GVIERAGMNGQGREAIVTDEIYWPNGL TLDYTLDMLYWIDAKESSI-SSVDFMGGNRRVVLAGQGRLPHPFGIAVFEDYIYWTDWES KSIERANKFTGSNQTTILSGLSDAMDVIVVNPLRQAPSK--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >S purpuratus --------------------------MGTYTLSLILLGLLACVFSAVNGNLCGENQFRCD NNKCIPSVWKCDNEDDCGDNSDETVCGQLTCSSAEFECVGSGAGNGGSTCIPARWRCDG- -DSDCPDGS-----DEIA--CQTLTCSPSQFSCG-PGKNCIPLTWRCDRDV-DCPSGADE HNCDALTCASNQFTCNNKKCVTTRWVCDGDNDCGDGSDEINCPSLTCAPDEFECTGHNET TCIPNRWKCDGDIDCRDGSDESSTHCSGPTVP---CSAGHFQCTSGECVHNSWKCDGERD CFDGSDEDSCPLVTPSPCAANEYQCDNGVCIPGDVECDGTQQCADGSDEANCNAPAECNP TTHFKCSNSTCLPMVRVCNGIPECPNNEDEPGQEICGRNECLTNNGGCSHTCLDLAIGHV CTCNAGYTLVN----ETQCVDINECKTTLGICSQRCYNLPGSYKCDCDENYTLENVNDRG HCKANPEFGAPKLLIANRHDIRIFDPSTSSEDYIKRSLHSAVAVE---FDSASNTVFWTD VGLEVVSKTQLQAENEVVPVVVTDKVKTPDGIAVDWINKLLYWTDTGVDNIVVSNFEGTR HTVLISSNLDEPRAIAVDPES-GLMFWSDWGL-GVIERAGMNGQGRTAIVTEGVSWPNGL TLDYTLDMLYWIDAKESSI-SCVDFMGGNRRVVVAGQGRISHPFSIAVFEDYIYWTDWTK ESIERADKFTGSNQTTILSGVSDAMDVIVVNPLRQAPYQ--------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------- >L variegatus --------------------SVIYIVYCPYRVIQSLM------FSFTLGNLCGGNQFTCA NNKCIPSVWKCDNEDDCGDNSDELVCGKLEASIFILYIILPP------YVAQTKAHAKA- ---KCASPHYGYIHSLIIAHTESLTCAPNQFSCG-PGKNCIPLTWRCDHDV-DCQTGADE HNCDALTCSANQFTCENKKCITTRWVCDGDNDCGDSSDEVNCPSLTCAPDQFECTGANET TCIPGRWKCDGDIDCRDGSDESTTHCSDAAIP---CPQGHFQCNSGECVRLSWKCDGEQD CFDGSDEESCAVITPTPCAPDEFQCANGVCIQGDVECNNVEECADGSDEANCNGPVDCNP TTHYRCKNSTCLPWVRVCNGIPECPDNEDEPGQEICGEQRI--------HYIYQIIYAKP 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