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Currency [0]/Explanatory TextB5Explanatory Text  0Good6Good  a1 Heading 1B Heading 1 I}O2 Heading 2B Heading 2 I}?3 Heading 3B Heading 3 I}234 Heading 44 Heading 4 I} 5InputpInput ̙ ??v 6 Linked CellF Linked Cell } 7Neutral<Neutral  e.Normal  8Noteb Note   9OutputrOutput  ???????????? ???:$Percent ;Title,Title I} <TotalHTotal OO= Warning Text: Warning Text XTableStyleMedium2PivotStyleMedium9`#USheet1Sheet2ISheet3" WxOntology Source GO:1903959+regulation of anion transmembrane transportGO_BiologicalProcess[VDAC1, VDAC2, VDAC3] GO:0000422autophagy of mitochondrion[BNIP3L, U2AF2, VDAC1] GO:0061726mitochondrion disassembly GO:1903146(regulation of autophagy of mitochondrion GO:0071806protein transmembrane transport[HSPD1, TOMM20, TOMM22] GO:0065002-intracellular protein transmembrane transport GO:0006626"protein targeting to mitochondrion&[BNIP3L, HSPD1, TOMM20, TOMM22, U2AF2] GO:00447439protein transmembrane import into intracellular organelle GO:00432432positive regulation of protein complex disassembly[CFL1, CFL2, DSTN] GO:1901879&regulation of protein depolymerization GO:0030042actin filament depolymerization GO:1901881/positive regulation of protein depolymerization GO:0030043actin filament fragmentation GO:0030834-regulation of actin filament depolymerization GO:00308366positive regulation of actin filament depolymerization GO:0030048actin filament-based movement![ATP2A2, CAV1, MYH10, MYH9, PKP2] GO:0098900regulation of action potential[ATP2A2, CAV1, PKP2] GO:0007009plasma membrane organization[ATP2A2, CAV1, EHD2] GO:00989012regulation of cardiac muscle cell action potential GO:1903115+regulation of actin filament-based movement GO:0086001$cardiac muscle cell action potential GO:0002027regulation of heart rate GO:0016264gap junction assembly[CAV1, CTNNA1, PKP2] GO:0086003cardiac muscle cell contraction GO:0006942)regulation of striated muscle contraction GO:0055117(regulation of cardiac muscle contraction GO:0086004-regulation of cardiac muscle cell contraction GO:00058513eukaryotic translation initiation factor 2B complexGO_CellularComponent[EIF2B5] GO:0005952%cAMP-dependent protein kinase complex [PRKAR2A] GO:0070939Dsl1/NZR complex[NBAS] GO:00058502eukaryotic translation initiation factor 2 complex[EIF2S2] GO:00162813eukaryotic translation initiation factor 4F complex[EIF4G3] GO:0019773.proteasome core complex, alpha-subunit complex[PSMA3] GO:0022625!cytosolic large ribosomal subunit[RPLP0, RPLP2] GO:0089701U2AF[U2AF2] GO:0000243commitment complex GO:0097425!smooth endoplasmic reticulum part[PGRMC1] GO:0030868%smooth endoplasmic reticulum membrane GO:00300625mitochondrial tricarboxylic acid cycle enzyme complex[BCKDHA] GO:00059477mitochondrial alpha-ketoglutarate dehydrogenase complex GO:0001674female germ cell nucleus[MARCKS] GO:0042585germinal vesicle GO:0046696#lipopolysaccharide receptor complex[HSPD1] GO:0019907Dcyclin-dependent protein kinase activating kinase holoenzyme complex GO:0000792heterochromatin[HIST1H1E, HMGA1, PSIP1] GO:0035327"transcriptionally active chromatin[HIST1H1C, PSIP1] GO:0035985+senescence-associated heterochromatin focus[HMGA1] GO:0005720nuclear heterochromatin[HIST1H1E, PSIP1] GO:0046930 pore complex GO:0031968organelle outer membrane4[BNIP3L, RMDN3, TOMM20, TOMM22, VDAC1, VDAC2, VDAC3] GO:0042645mitochondrial nucleoid[VDAC1, VDAC2] GO:00057572mitochondrial permeability transition pore complex[VDAC1] GO:0005741mitochondrial outer membrane GO:0044233&ER-mitochondrion membrane contact site[TOMM20] GO:0098573-intrinsic component of mitochondrial membrane[TOMM20, TOMM22] GO:0098799,outer mitochondrial membrane protein complex GO:00057420mitochondrial outer membrane translocase complex GO:00313063intrinsic component of mitochondrial outer membrane GO:0032592,integral component of mitochondrial membrane GO:00313072integral component of mitochondrial outer membrane GO:0044291cell-cell contact zone[ATP2A2, CTNNA1, PKP2] GO:0014704intercalated disc GO:0005915zonula adherens[CTNNA1] GO:0044853plasma membrane raft[CAV1, CTNNA1, EHD2, PRKAR2A] GO:0031095'platelet dense tubular network membrane[ATP2A2] GO:0005901caveola[CAV1, CTNNA1, EHD2] GO:0016529sarcoplasmic reticulum[ANK1, ATP2A2] GO:0014731 spectrin-associated cytoskeleton[ANK1] GO:0014801#longitudinal sarcoplasmic reticulum GO:0016600flotillin complex GO:0090534'calcium ion-transporting ATPase complex GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex[CAV1] GO:0032153cell division site [MYH10, MYH9] GO:0060187 cell pole[VANGL2] GO:0070938contractile ring[MYH9] GO:0032155cell division site part GO:0097610cell surface furrow GO:0032154cleavage furrow GO:0032432actin filament bundle[MARCKS, MYH10, MYH9, VANGL2] GO:0042641 actomyosin[MYH10, MYH9, VANGL2] GO:0016460myosin II complex GO:0032982myosin filament GO:0005826actomyosin contractile ring GO:0030863cortical cytoskeleton[CFL1, DSTN, MYH9] GO:0030864cortical actin cytoskeleton GO:0097517!contractile actin filament bundle GO:0001725 stress fiber GO:0097513myosin II filament GO:0034186apolipoprotein A-I bindingGO_MolecularFunction GO:0051015actin filament binding/[CFL1, CFL2, CTNNA1, DSTN, MARCKS, MYH10, MYH9] GO:0097100supercoiled DNA binding[PSIP1] GO:00086030cAMP-dependent protein kinase regulator activity GO:0017166vinculin binding[CTNNA1, SORBS3] GO:0030628pre-mRNA 3'-splice site binding GO:0008135(translation factor activity, RNA binding[EIF2B5, EIF2S2, EIF4G3] GO:0003743&translation initiation factor activity GO:0000033&alpha-1,3-mannosyltransferase activity[ALG3] GO:0052925Gdol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity GO:00317754lutropin-choriogonadotropic hormone receptor binding GO:0086039ecalcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential GO:0086083[cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication[PKP2] GO:0005080protein kinase C binding[MARCKS, PKP2] GO:0016724Aoxidoreductase activity, oxidizing metal ions, oxygen as acceptor[FTMT] GO:0004322ferroxidase activity GO:0001160*transcription termination site DNA binding[XRN2] GO:00045345'-3' exoribonuclease activity GO:0001147<transcription termination site sequence-specific DNA binding GO:0003826%alpha-ketoacid dehydrogenase activity GO:0016624]oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor GO:0003863O3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity GO:0032934sterol binding [CAV1, OSBP] GO:0008142oxysterol binding[OSBP] GO:00703205inward rectifier potassium channel inhibitor activity GO:0032552deoxyribonucleotide binding [HIST1H1E] GO:0032554"purine deoxyribonucleotide binding GO:0032558"adenyl deoxyribonucleotide binding GO:0032564 dATP binding GO:0043531 ADP binding[HIST1H1E, MYH10, MYH9] GO:0000146microfilament motor activity GO:00228840macromolecule transmembrane transporter activity GO:0042887(amide transmembrane transporter activity GO:1904680*peptide transmembrane transporter activity GO:0008320*protein transmembrane transporter activity GO:0030943(mitochondrion targeting sequence binding GO:0015266protein channel activity GO:0016667;oxidoreductase activity, acting on a sulfur group of donors [SQOR, TMX1] GO:0016860&intramolecular oxidoreductase activity[PTGES3, TMX1] GO:0016672doxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor[SQOR] GO:0050220!prostaglandin-E synthase activity[PTGES3] GO:0070224'sulfide:quinone oxidoreductase activity GO:0003720telomerase activity GO:0016708oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor[VDAC2] GO:0047726$iron-cytochrome-c reductase activity GO:00041283cytochrome-b5 reductase activity, acting on NAD(P)H<? GO:0008941!nitric oxide dioxygenase activity GO:0022829wide pore channel activity GO:0005253anion channel activity GO:0015288porin activity GO:0008308$voltage-gated anion channel activity GO:0016835carbon-oxygen lyase activity[HACD3, HMGA1, PUS1] GO:0051575)5'-deoxyribose-5-phosphate lyase activity GO:0016836hydro-lyase activity [HACD3, PUS1] GO:0004730!pseudouridylate synthase activity[PUS1] GO:0018812&3-hydroxyacyl-CoA dehydratase activity[HACD3] GO:01021586very-long-chain 3-hydroxyacyl-CoA dehydratase activity GO:0102343-3-hydroxy-arachidoyl-CoA dehydratase activity GO:0102344+3-hydroxy-behenoyl-CoA dehydratase activity GO:0102345.3-hydroxy-lignoceroyl-CoA dehydratase activityGO ID 7GO Term 7 Group P-Value 7/Group P Value Corrected with Benjamini-Hochberg 7Associated Genes 7GO_BiologicalProcess 7[CFL1, CFL2, DSTN] 7GO_CellularComponent 7GO_MolecularFunction 7Supplementary Table 1. 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