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Warning Text %XTableStyleMedium2PivotStyleLight16`Sheet1PjSheet2kSheet34 [ GO_accession Description Term_typeOver_represented_pValueCorrected_pValueDEG_itemDEG_listBg_item GO:0002376immune system processbiological_process GO:0001775cell activation GO:0022610biological adhesion GO:0002684,positive regulation of immune system process GO:0045321leukocyte activation GO:0007155 cell adhesion GO:0006955immune response GO:0044421extracellular region partcellular_component GO:0002682#regulation of immune system process GO:0046649lymphocyte activation GO:0005576extracellular region GO:0007275$multicellular organismal development GO:0030155regulation of cell adhesion GO:0016337$single organismal cell-cell adhesion GO:0031012extracellular matrix GO:0048731system development GO:0002521leukocyte differentiation GO:0002520immune system development GO:0098609cell-cell adhesion GO:0007166'cell surface receptor signaling pathway GO:0048513organ development GO:0030097 hemopoiesis GO:0098602single organism cell adhesion GO:0034109homotypic cell-cell adhesion GO:0009986 cell surface GO:0048534+hematopoietic or lymphoid organ development GO:0048856 anatomical structure development GO:0010033response to organic substance GO:0044459plasma membrane part GO:0022407 regulation of cell-cell adhesion GO:0005578"proteinaceous extracellular matrix GO:0048518)positive regulation of biological process GO:0042110T cell activation GO:0070489T cell aggregation GO:0050865regulation of cell activation GO:0071593lymphocyte aggregation GO:0044767%single-organism developmental process GO:0070486leukocyte aggregation GO:0007159leukocyte cell-cell adhesion GO:0051239.regulation of multicellular organismal process GO:0034110*regulation of homotypic cell-cell adhesion GO:0032502developmental process GO:00512407positive regulation of multicellular organismal process GO:0044699single-organism process GO:0030154cell differentiation GO:0070887&cellular response to chemical stimulus GO:0048522'positive regulation of cellular process GO:0032633interleukin-4 production GO:0008283cell proliferation GO:0050863regulation of T cell activation GO:0050870(positive regulation of T cell activation GO:0002694"regulation of leukocyte activation GO:19030393positive regulation of leukocyte cell-cell adhesion GO:00341123positive regulation of homotypic cell-cell adhesion GO:0044763 single-organism cellular process GO:0051249#regulation of lymphocyte activation GO:0046651lymphocyte proliferation GO:1903037*regulation of leukocyte cell-cell adhesion GO:0006950response to stress GO:0050776regulation of immune response GO:0032943mononuclear cell proliferation GO:0048869cellular developmental process GO:0051251,positive regulation of lymphocyte activation GO:0002696+positive regulation of leukocyte activation GO:0050778&positive regulation of immune response GO:0071310&cellular response to organic substance GO:0050867&positive regulation of cell activation GO:0098552side of membrane GO:0009897 external side of plasma membrane GO:0045785$positive regulation of cell adhesion GO:0070661leukocyte proliferation GO:20000262regulation of multicellular organismal development GO:0032496response to lipopolysaccharide GO:0005509calcium ion bindingmolecular_function GO:1903708"positive regulation of hemopoiesis GO:0006952defense response GO:0048584+positive regulation of response to stimulus GO:0022409)positive regulation of cell-cell adhesion GO:0002237(response to molecule of bacterial origin GO:0002764,immune response-regulating signaling pathway GO:0001816cytokine production GO:0030098lymphocyte differentiation GO:0050896response to stimulus GO:0048583"regulation of response to stimulus GO:19021070positive regulation of leukocyte differentiation GO:0051179 localization GO:0009605response to external stimulus GO:0032673&regulation of interleukin-4 production GO:0031988membrane-bounded vesicle GO:0042127 regulation of cell proliferation GO:0051094,positive regulation of developmental process GO:0050670&regulation of lymphocyte proliferation GO:0001819*positive regulation of cytokine production GO:0032944,regulation of mononuclear cell proliferation GO:0002253activation of immune response GO:0002573!myeloid leukocyte differentiation GO:0031982vesicle GO:0040017!positive regulation of locomotion GO:0050839cell adhesion molecule binding GO:0070663%regulation of leukocyte proliferation GO:0005764lysosome GO:0000323 lytic vacuole GO:0045597+positive regulation of cell differentiation GO:1903561extracellular vesicle GO:0043230extracellular organelle GO:1901700&response to oxygen-containing compound GO:0042113B cell activation GO:0032753/positive regulation of interleukin-4 production GO:0002757.immune response-activating signal transduction GO:0070062extracellular exosome GO:0065010(extracellular membrane-bounded organelle GO:1903706regulation of hemopoiesis GO:00512722positive regulation of cellular component movement GO:1902105'regulation of leukocyte differentiation GO:0009617response to bacterium GO:0005515protein binding GO:0042102+positive regulation of T cell proliferation GO:0001817!regulation of cytokine production GO:00486617positive regulation of smooth muscle cell proliferation GO:0005615extracellular space GO:0002768Bimmune response-regulating cell surface receptor signaling pathway GO:0000779(condensed chromosome, centromeric region GO:0030217T cell differentiation GO:0030335%positive regulation of cell migration GO:0042129"regulation of T cell proliferation GO:0030099myeloid cell differentiation GO:0050663cytokine secretion GO:0005773vacuole GO:0050793#regulation of developmental process GO:00007800condensed nuclear chromosome, centromeric region GO:2000147$positive regulation of cell motility GO:0050671/positive regulation of lymphocyte proliferation GO:0032879regulation of localization GO:00329465positive regulation of mononuclear cell proliferation GO:0009719response to endogenous stimulus GO:0044707%single-multicellular organism process GO:00512417negative regulation of multicellular organismal process GO:0009888tissue development GO:0070665.positive regulation of leukocyte proliferation GO:0071363+cellular response to growth factor stimulus GO:0005581collagen trimer GO:0031349'positive regulation of defense response GO:0002250adaptive immune response GO:0032501 multicellular organismal process GO:0034097response to cytokine GO:0070848response to growth factor GO:0048585+negative regulation of response to stimulus GO:0071222'cellular response to lipopolysaccharide GO:0071216$cellular response to biotic stimulus GO:0051301 cell division GO:0043207$response to external biotic stimulus GO:0051707response to other organism GO:0050851+antigen receptor-mediated signaling pathway GO:0006810 transport GO:0042098T cell proliferation GO:00712191cellular response to molecule of bacterial origin GO:0005539glycosaminoglycan binding GO:0009611response to wounding GO:0008284)positive regulation of cell proliferation GO:0035987endodermal cell differentiation GO:0032640 tumor necrosis factor production GO:0032680.regulation of tumor necrosis factor production GO:0051270)regulation of cellular component movement GO:0051234establishment of localization GO:00321024negative regulation of response to external stimulus GO:0030334regulation of cell migration GO:0000940&condensed chromosome outer kinetochore GO:0050707 regulation of cytokine secretion GO:1903555Cregulation of tumor necrosis factor superfamily cytokine production GO:0035850>epithelial < cell differentiation involved in kidney development GO:0030199collagen fibril organization GO:0051704multi-organism process GO:00071670enzyme linked receptor protein signaling pathway GO:0032835glomerulus development GO:0001706endoderm formation GO:0060326cell chemotaxis GO:00717065tumor necrosis factor superfamily cytokine production GO:0032940secretion by cell GO:0048519)negative regulation of biological process GO:0016477cell migration GO:0051050 positive regulation of transport GO:0032101+regulation of response to external stimulus GO:0072358!cardiovascular system development GO:0072359circulatory system development GO:0009607response to biotic stimulus GO:0002429Bimmune response-activating cell surface receptor signaling pathway GO:0051222(positive regulation of protein transport GO:0000942.condensed nuclear chromosome outer kinetochore GO:0040012regulation of locomotion GO:0050840extracellular matrix binding GO:0071702organic substance transport GO:0051246'regulation of protein metabolic process GO:0018193 peptidyl-amino acid modification GO:0005518collagen binding GO:0006897 endocytosis GO:0050708regulation of protein secretion GO:0002252immune effector process GO:0006468protein phosphorylation GO:0044420extracellular matrix component GO:2000145regulation of cell motility GO:0044765single-organism transport GO:0009306protein secretion GO:0002460yadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0033993response to lipid GO:0071495(cellular response to endogenous stimulus GO:0043534'blood vessel endothelial cell migration GO:1903034"regulation of response to wounding GO:00456393positive regulation of myeloid cell differentiation GO:0006959humoral immune response GO:0035710*CD4-positive, alpha-beta T cell activation GO:0005102receptor binding GO:0001934.positive regulation of protein phosphorylation GO:0045087innate immune response GO:0045595"regulation of cell differentiation GO:0065009 regulation of molecular function GO:0008037cell recognition GO:0051347+positive regulation of transferase activity GO:0010631epithelial cell migration GO:0018209peptidyl-serine modification GO:0061045$negative regulation of wound healing GO:0005201+extracellular matrix structural constituent GO:0070492oligosaccharide binding GO:0009966!regulation of signal transduction GO:0072160.nephron tubule epithelial cell differentiation GO:00512470positive regulation of protein metabolic process GO:0090132epithelium migration GO:0018108!peptidyl-tyrosine phosphorylation GO:0007179:transforming growth factor beta receptor signaling pathway GO:0032880"regulation of protein localization GO:0050715)positive regulation of cytokine secretion GO:0046631alpha-beta T cell activation GO:0040011 locomotion GO:0018212peptidyl-tyrosine modification GO:0001944vasculature development GO:1902578single-organism localization GO:0000775chromosome, centromeric region GO:0050714(positive regulation of protein secretion GO:0071560=cellular response to transforming growth factor beta stimulus GO:0051784'negative regulation of nuclear division GO:0032615interleukin-12 production GO:0048660.regulation of smooth muscle cell proliferation GO:00327607positive regulation of tumor necrosis factor production GO:00610053cell differentiation involved in kidney development GO:0071559+response to transforming growth factor beta GO:0051049regulation of transport GO:0090130tissue migration GO:0051302regulation of cell division GO:0002822regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:1903557Lpositive regulation of tumor necrosis factor superfamily cytokine production GO:0097285$cell-type specific apoptotic process GO:0031347regulation of defense response GO:0080134 regulation of response to stress GO:0048523'negative regulation of cellular process GO:0005886plasma membrane GO:0030198!extracellular matrix organization GO:0051223regulation of protein transport GO:0048870 cell motility GO:0051674localization of cell GO:0042327&positive regulation of phosphorylation GO:0071944cell periphery GO:0048659 smooth muscle cell proliferation GO:0043062$extracellular structure organization GO:0043542endothelial cell migration GO:0001568blood vessel development GO:0043537>negative regulation of blood vessel endothelial cell migration GO:0051783regulation of nuclear division GO:0051716cellular response to stimulus GO:0032656'regulation of interleukin-13 production GO:0042221response to chemical GO:0000778(condensed nuclear chromosome kinetochore GO:0007059chromosome segregation GO:0006954inflammatory response GO:0023056 positive regulation of signaling GO:00027638positive regulation of myeloid leukocyte differentiation GO:00022922T cell differentiation involved in immune response GO:0008150 GO:0042100B cell proliferation GO:0038024cargo receptor activity GO:00456211positive regulation of lymphocyte differentiation GO:0044877macromolecular complex binding GO:00321034positive regulation of response to external stimulus GO:0045637*regulation of myeloid cell differentiation GO:20005148regulation of CD4-positive, alpha-beta T cell activation GO:0070613 regulation of protein processing GO:0000776 kinetochore GO:0030162regulation of proteolysis GO:0050866&negative regulation of cell activation GO:0006928)movement of cell or subcellular component GO:0065007biological regulation GO:0002819&regulation of adaptive immune response GO:0030574collagen catabolic process GO:00105623positive regulation of phosphorus metabolic process GO:00459372positive regulation of phosphate metabolic process GO:00518971positive regulation of protein kinase B signaling GO:0044712!single-organism catabolic process GO:0032616interleukin-13 production GO:0098644complex of collagen trimers GO:0007492endoderm development GO:00314013positive regulation of protein modification process GO:1903317 regulation of protein maturation GO:0032403protein complex binding GO:0030195(negative regulation of blood coagulation GO:1900047!negative regulation of hemostasis GO:0010647)positive regulation of cell communication GO:00106340positive regulation of epithelial cell migration GO:0001655urogenital system development GO:0046903 secretion GO:0009967*positive regulation of signal transduction GO:00023660leukocyte activation involved in immune response GO:0050789 regulation of biological process GO:0043367/CD4-positive, alpha-beta T cell differentiation GO:0032609interferon-gamma production GO:0060429epithelium development GO:0071345&cellular response to cytokine stimulus GO:0002263+cell activation involved in immune response GO:0007178Htransmembrane receptor protein serine/threonine kinase signaling pathway GO:0001771immunological synapse formation GO:0002761/regulation of myeloid leukocyte differentiation GO:00486468anatomical structure formation involved in morphogenesis GO:0044093)positive regulation of molecular function GO:00322680regulation of cellular protein metabolic process GO:00106046positive regulation of macromolecule metabolic process GO:0005488binding GO:0050673epithelial cell proliferation GO:0009968*negative regulation of signal transduction GO:0016042lipid catabolic process GO:0033674&positive regulation of kinase activity GO:0045860.positive regulation of protein kinase activity GO:0031295T cell costimulation GO:0014910*regulation of smooth muscle cell migration GO:2000516Apositive regulation of CD4-positive, alph<}a-beta T cell activation GO:0032674&regulation of interleukin-5 production GO:0046632!alpha-beta T cell differentiation GO:0061041regulation of wound healing GO:0031399*regulation of protein modification process GO:0014012+peripheral nervous system axon regeneration GO:0035712T-helper 2 cell activation GO:2000569(regulation of T-helper 2 cell activation GO:20005701positive regulation of T-helper 2 cell activation GO:0004720!protein-lysine 6-oxidase activity GO:0038085*vascular endothelial growth factor binding GO:0005588collagen type V trimer GO:0046098guanine metabolic process GO:0032653'regulation of interleukin-10 production GO:0072006nephron development GO:0031577spindle checkpoint GO:0050819"negative regulation of coagulation GO:00322709positive regulation of cellular protein metabolic process GO:0048520positive regulation of behavior GO:0015849organic acid transport GO:0050794regulation of cellular process GO:0030316osteoclast differentiation GO:0008285)negative regulation of cell proliferation GO:00702013regulation of establishment of protein localization GO:0010632'regulation of epithelial cell migration GO:1903530regulation of secretion by cell GO:1901701/cellular response to oxygen-containing compound GO:20003539positive regulation of endothelial cell apoptotic process GO:0009653"anatomical structure morphogenesis GO:0044706$multi-multicellular organism process GO:00149113positive regulation of smooth muscle cell migration GO:0002504Yantigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0044243*multicellular organismal catabolic process GO:0031294lymphocyte costimulation GO:00108009positive regulation of peptidyl-threonine phosphorylation GO:0032634interleukin-5 production GO:0051782$negative regulation of cell division GO:0000793condensed chromosome GO:0045582-positive regulation of T cell differentiation GO:0006935 chemotaxis GO:0042330taxis GO:0023057 negative regulation of signaling GO:0010243#response to organonitrogen compound GO:19025338positive regulation of intracellular signal transduction GO:0051604protein maturation GO:00435355regulation of blood vessel endothelial cell migration GO:0023051regulation of signaling GO:0002286-T cell activation involved in immune response GO:0030054 cell junction GO:0010646 regulation of cell communication GO:0015711organic anion transport GO:00313251positive regulation of cellular metabolic process GO:0043066(negative regulation of apoptotic process GO:0010543!regulation of platelet activation GO:0048485&sympathetic nervous system development GO:0035295tube development GO:00507318positive regulation of peptidyl-tyrosine phosphorylation GO:0046634*regulation of alpha-beta T cell activation GO:0097367carbohydrate derivative binding GO:0032613interleukin-10 production GO:00300713regulation of mitotic metaphase/anaphase transition GO:19020999regulation of metaphase/anaphase transition of cell cycle GO:0042093T-helper cell differentiation GO:0018105peptidyl-serine phosphorylation GO:0043085)positive regulation of catalytic activity GO:0010544*negative regulation of platelet activation GO:0045295gamma-catenin binding GO:0005583fibrillar collagen trimer GO:0098643banded collagen fibril GO:0033044%regulation of chromosome organization GO:0043069,negative regulation of programmed cell death GO:0032963collagen metabolic process GO:0032655'regulation of interleukin-12 production GO:00070913metaphase/anaphase transition of mitotic cell cycle GO:00109651regulation of mitotic sister chromatid separation GO:0044784+metaphase/anaphase transition of cell cycle GO:0002294KCD4-positive, alpha-beta T cell differentiation involved in immune response GO:0001667ameboidal-type cell migration GO:0010648)negative regulation of cell communication GO:0050790 regulation of catalytic activity GO:0060548!negative regulation of cell death GO:0001935endothelial cell proliferation GO:0050900leukocyte migration GO:00442598multicellular organismal macromolecule metabolic process GO:00022878alpha-beta T cell activation involved in immune response GO:0002293=alpha-beta T cell differentiation involved in immune response GO:0071241(cellular response to inorganic substance GO:0033002muscle cell proliferation GO:0032649)regulation of interferon-gamma production GO:00327350positive regulation of interleukin-12 production GO:0051180vitamin transport GO:0000777 condensed chromosome kinetochore GO:0014909smooth muscle cell migration GO:0010038response to metal ionVSupplementary Table 5. 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C CL?C(AG?C@Cx@C"@ C" C# CCJoL?C(AG?C@Cx@C"@ C$ C% CCJoL?C(AG?C@Cx@C"@ C& C' CCJoL?C(AG?C@Cx@C"@ C( C) C C2nʴM?CrSrN?C*@Cx@Ci@ C* C+ C C[KN?C?C8@Cx@CX@ C, C- C CrEsrN?C͋_?C@Cx@CA@ C. C/ C CwXUO?Cyt?C@Cx@CA@ C0 C1 C CS̽-O?Cyt?C@Cx@CA@ C2 C3 C CS̽-O?Cyt?C@Cx@CA@ C4 C5 C CS̽-O?Cyt?C@Cx@CA@ C6 C7 C Cڂ1dm:O?Cyt?C@Cx@CA@ C8 C9 C C}xGO?Cyt?C,@Cx@C@m@ C: C; C CO?C䃞ͪϥ?C?@Cx@Ch@ C< C= C CokTP?C0DK?CF@Cx@C0@ C> C? C CǘP?C|ݮ?C9@Cx@Cp@ C@ CA C Cr\P?Cզ?C@Cx@CQ@ CB CC C Cc'P?CI/j?C(@Cx@Cg@ CD CE C CMPy*Q?CXR>ǧ?C@Cx@CA@Dljjjjjjjjjjjjjjjjjjjjjjjjjjjjjjj,,,,,,,,,, CF CG C CөQ?CKXU?C@Cx@CA@ CH CI C CөQ?CKXU?C@Cx@CA@ CJ CK C CIR?Cp>??C@Cx@CQ@ CL CM C Cm2dR?CY,E?C@Cx@CQ@ CN CO C C0vgR?CY,E?C@Cx@CQ@ CP CQ C C~iqR?CCY?C@Cx@C5@ CR CS C C/$R?CCY?C@Cx@C5@ CT CU CC 1R?C^?C@Cx@C5@ CV CW C CIR?C^?C@Cx@C5@ CX CY C C=FR?CyȔ?C"@Cx@C\@jjjjjjjjj>@dCB ggD f2ɀ bk  dMbP?_*+%&?'?(?)?" dRQ?RQ?&QU>@d ggD f2ɀ l  dMbP?_*+%&?'?(?)?" dRQ?RQ?&QU>@d ggD DocumentSummaryInformation8lCompObjkx  Sheet1Sheet2Sheet3  Worksheetsd ?GKSOProductBuildVer2052-11.1.0.9305 FMicrosoft Excel 2003 WorksheetBiff8Excel.Sheet.89q