ࡱ>  ZO\pBarath Ba==\508X@"1MArial1MArial1MArial1MArial1MArial1.MTimes New Roman1.MTimes New Roman1 h6I{~ Light1,6I{~16I{~16I{~1I{~1I{~1<I{~1>I{~1?I{~14I{~14I{~1 I{~1 I{~1I{~1I{~1 I{~1I{~1[SO1.Times New Roman1.Times New Roman""#,##0;""\-#,##0""#,##0;[Red]""\-#,##0""#,##0.00;""\-#,##0.00#""#,##0.00;[Red]""\-#,##0.007*2_ ""* #,##0_ ;_ ""* \-#,##0_ ;_ ""* "-"_ ;_ @_ .))_ * #,##0_ ;_ * \-#,##0_ ;_ * "-"_ ;_ @_ ?,:_ ""* #,##0.00_ ;_ ""* \-#,##0.00_ ;_ ""* "-"??_ ;_ @_ 6+1_ * #,##0.00_ ;_ * \-#,##0.00_ ;_ * "-"??_ ;_ @_ \$#,##0_);\(\$#,##0\)\$#,##0_);[Red]\(\$#,##0\) \$#,##0.00_);\(\$#,##0.00\)% \$#,##0.00_);[Red]\(\$#,##0.00\)                                     P  P          a> , *   ff   ` + )              !X5 !  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40% - @wr 2 L˭ % 40% - @wr 3G' 40% - @wr 3 L % 40% - @wr 4G+ 40% - @wr 4 L % 40% - @wr 5G/ 40% - @wr 5 L % 40% - @wr 6G3 40% - @wr 6  L % 60% - @wr 1G 60% - @wr 1 23 % 60% - @wr 2G$ 60% - @wr 2 23 % 60% - @wr 3G( 60% - @wr 3 23 % 60% - @wr 4G, 60% - @wr 4 23f % 60% - @wr 5G0 60% - @wr 5 23 %! 60% - @wr 6G4 60% - @wr 6  23Ў %"~vRk #h+h DTj% $h 1=h 1 DTj%Dr %h 2=h 2 DTj%? &h 3=h 3 DTj%23 'h 4/h 4 DTj%(]5]  %8^ĉ)}Y5}Y  a% *Gl;`GGl;` %DrDr+'^, '^[0] -{o{  }% .hgUSCQnegative regulation of phosphatidylinositol 3-kinase signalingNCOR1 GO:0033235*positive regulation of protein sumoylationPIAS1 GO:0046475%glycerophospholipid catabolic process GO:0015711organic anion transport GO:0030299!intestinal cholesterol absorption GO:0090312,positive regulation of protein deacetylation GO:0021794thalamus development GO:0045066!regulatory T cell differentiation GO:0010866/regulation of triglyceride biosynthetic process GO:0033233!regulation of protein sumoylation GO:0034383*low-density lipoprotein particle clearance GO:0044241lipid digestion GO:00511500regulation of smooth muscle cell differentiation GO:00902085positive regulation of triglyceride metabolic process GO:0060216definitive hemopoiesis GO:0006820anion transport GO:0031063#regulation of histone deacetylation GO:0046329"negative regulation of JNK cascade GO:0050892intestinal absorption GO:2000191"regulation of fatty acid transport GO:00603349regulation of interferon-gamma-mediated signaling pathway GO:0060330*regulation of response to interferon-gamma GO:0090207,regulation of triglyceride metabolic process GO:0006110 regulation of glycolytic process GO:00328734negative regulation of stress-activated MAPK cascade GO:0070303Hnegative regulation of stress-activated protein kinase signaling cascade GO:0009395phospholipid catabolic process GO:0090311#regulation of protein deacetylation GO:0034381%plasma lipoprotein particle clearance GO:0043470,regulation of carbohydrate catabolic process GO:00434715regulation of cellular carbohydrate catabolic process GO:0000122Dnegative regulation of transcription from RNA polymerase II promoter NCOR1//PIAS1 GO:0030163protein catabolic process PIAS1//LDLR GO:0046503glycerolipid catabolic process GO:0016925protein sumoylation GO:00313251positive regulation of cellular metabolic process GO:0032890$regulation of organic acid transport GO:0050994%regulation of lipid catabolic process GO:0032436Ppositive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0051225spindle assembly GO:0032922'circadian regulation of gene expression GO:0043367/CD4-positive, alpha-beta T cell differentiation GO:0051145"smooth muscle cell differentiation GO:0009893(positive regulation of metabolic process GO:0015914phospholipid transport GO:0031058+positive regulation of histone modification GO:00468891positive regulation of lipid biosynthetic process GO:1901800<positive regulation of proteasomal protein catabolic process GO:0046164alcohol catabolic process GO:00970060regulation of plasma lipoprotein particle levels GO:1903052Qpositive regulation of proteolysis involved in cellular protein catabolic process GO:1903310-positive regulation of chromatin modification GO:0044248cellular catabolic process GO:0035710*CD4-positive, alpha-beta T cell activation GO:0016575histone deacetylation GO:0019432!triglyceride biosynthetic process GO:0046460"neutral lipid biosynthetic process GO:0046463!acylglycerol biosynthetic process GO:00511492positive regulation of muscle cell differentiation GO:0048878chemical homeostasis GO:0030521#androgen receptor signaling pathway GO:0044275'cellular carbohydrate catabolic process GO:2001252.positive regulation of chromosome organization GO:1901575#organic substance catabolic process GO:00314013positive regulation of protein modification process GO:0006476protein deacetylation GO:0015918sterol transport GO:0030301cholesterol transport GO:1901616*organic hydroxy compound catabolic process GO:00140665regulation of phosphatidylinositol 3-kinase signaling GO:0046470%phosphatidylcholine metabolic process GO:0006096glycolytic process GO:0035601protein deacylation GO:0098732macromolecule deacylation GO:0044255 cellular lipid metabolic process GO:0015908fatty acid transport GO:0015748organophosphate ester transport GO:0022600digestive system process GO:0043467<regulation of generation of precursor metabolites and energy GO:0046632!alpha-beta T cell differentiation GO:00458923negative regulation of transcription, DNA-templated PIAS1//NCOR1 GO:0060333+interferon-gamma-mediated signaling pathway GO:0032434Gregulation of proteasomal ubiquitin-dependent protein catabolic process GO:1902679/negative regulation of RNA biosynthetic process GO:0080134 regulation of response to stress GO:0009056catabolic process GO:00322709positive regulation of cellular protein metabolic process GO:0001523retinoid metabolic process GO:0032368regulation of lipid transport GO:0033238.regulation of cellular amine metabolic process GO:0051253,negative regulation of RNA metabolic process GO:0044070regulation of anion transport GO:00424392ethanolamine-containing compound metabolic process GO:0014065'phosphatidylinositol 3-kinase signaling GO:0016101diterpenoid metabolic process GO:0040014+regulation of multicellular organism growth GO:0045862"positive regulation of proteolysis GO:0007051spindle organization GO:0007603 phototransduction, visible light GO:2000113Bnegative regulation of cellular macromolecule biosynthetic process GO:00019591regulation of cytokine-mediated signaling pathway GO:0006090pyruvate metabolic process GO:0009057macromolecule catabolic process GO:0010629&negative regulation of gene expression GO:00512470positive regulation of protein metabolic process GO:0006721terpenoid metabolic process GO:00611363regulation of proteasomal protein catabolic process GO:0031056"regulation of histone modification GO:0046631alpha-beta T cell activation GO:0071346%cellular response to interferon-gamma GO:0010954)positive regulation of protein processing GO:0030218erythrocyte differentiation GO:1903319)positive regulation of protein maturation GO:0045934Gnegative regulation of nucleobase-containing compound metabolic process GO:0042472inner ear morphogenesisSOBP GO:0060759+regulation of response to cytokine stimulus GO:1903308$regulation of chromatin modification GO:00105589negative regulation of macromolecule biosynthetic process GO:0051172:negative regu<Klation of nitrogen compound metabolic process GO:0045834.positive regulation of lipid metabolic process GO:0034101erythrocyte homeostasis GO:1902275$regulation of chromatin organization GO:0006641triglyceride metabolic process GO:0009584detection of visible light GO:1903050Hregulation of proteolysis involved in cellular protein catabolic process GO:0032501 multicellular organismal processNCOR1//PIAS1//SOBP//LDLR GO:0007602phototransduction GO:00457320positive regulation of protein catabolic process GO:0046890(regulation of lipid biosynthetic process GO:00313274negative regulation of cellular biosynthetic process GO:0006639acylglycerol metabolic process GO:0006638neutral lipid metabolic process GO:19033620regulation of cellular protein catabolic process GO:0006720isoprenoid metabolic process GO:0009890+negative regulation of biosynthetic process GO:00305188intracellular steroid hormone receptor signaling pathway GO:0051147)regulation of muscle cell differentiation GO:0008203cholesterol metabolic process GO:0021536diencephalon development GO:0034341response to interferon-gamma GO:0042157lipoprotein metabolic process GO:0042471ear morphogenesis GO:0002262myeloid cell homeostasis GO:0009583detection of light stimulus GO:0043409#negative regulation of MAPK cascade GO:0031399*regulation of protein modification process GO:0006629lipid metabolic process GO:0065003macromolecular complex assembly GO:0065004protein-DNA complex assembly GO:0006576)cellular biogenic amine metabolic process GO:0015718monocarboxylic acid transport GO:0016125sterol metabolic process GO:0007259JAK-STAT cascade GO:0007586 digestion GO:0007605sensory perception of sound GO:00106755regulation of cellular carbohydrate metabolic process GO:0033044%regulation of chromosome organization GO:0044724.single-organism carbohydrate catabolic process GO:0006109,regulation of carbohydrate metabolic process GO:0042592homeostatic process GO:0046328regulation of JNK cascade GO:0016052carbohydrate catabolic process GO:0050954)sensory perception of mechanical stimulus GO:0007623circadian rhythm GO:0071824(protein-DNA complex subunit organization GO:0044242 cellular lipid catabolic process GO:00313311positive regulation of cellular catabolic process GO:0035264multicellular organism growth GO:1903322Spositive regulation of protein modification by small protein conjugation or removal GO:0006811 ion transport GO:0007219Notch signaling pathway GO:0032872+regulation of stress-activated MAPK cascade GO:0070302?regulation of stress-activated protein kinase signaling cascade GO:0015850"organic hydroxy compound transport GO:0009581detection of external stimulus GO:0048522'positive regulation of cellular process GO:0009582detection of abiotic stimulus GO:0048839inner ear development GO:00313284positive regulation of cellular biosynthetic process LDLR//PIAS1 GO:0007254 JNK cascade GO:0009891+positive regulation of biosynthetic process GO:0031326+regulation of cellular biosynthetic processPIAS1//NCOR1//LDLR GO:0007626locomotory behavior GO:0030217T cell differentiation GO:0009889"regulation of biosynthetic process GO:0048015'phosphatidylinositol-mediated signaling GO:0048017!inositol lipid-mediated signaling GO:0007179:transforming growth factor beta receptor signaling pathway GO:0006357;regulation of transcription from RNA polymerase II promoter GO:0070613 regulation of protein processing GO:1903317 regulation of protein maturation GO:00322680regulation of cellular protein metabolic process GO:00063678transcription initiation from RNA polymerase II promoter GO:0006898receptor-mediated endocytosis GO:0044106 cellular amine metabolic process GO:0043583ear development GO:0009896(positive regulation of catabolic process GO:0035257 nuclear hormone receptor bindingMolecular function GO:0051427hormone receptor binding GO:0003714"transcription corepressor activity GO:0005041)low-density lipoprotein receptor activity GO:0019789SUMO ligase activity GO:0032183 SUMO binding GO:0030228&lipoprotein particle receptor activity GO:0030169(low-density lipoprotein particle binding GO:0046965retinoid X receptor binding GO:0003712transcription cofactor activity GO:0071813lipoprotein particle binding GO:0071814protein-lipid complex binding GO:0019787)small conjugating protein ligase activity GO:0000989:transcription factor binding transcription factor activity GO:0000988-protein binding transcription factor activity GO:0046966 thyroid hormone receptor binding GO:00011029RNA polymerase II activating transcription factor binding GO:0050681androgen receptor binding GO:0042974retinoic acid receptor binding GO:0033613'activating transcription factor binding GO:0038024cargo receptor activity GO:0035258 steroid hormone receptor binding GO:0042826histone deacetylase binding GO:0016881acid-amino acid ligase activity GO:0001948glycoprotein binding GO:0032182!small conjugating protein binding GO:0001085.RNA polymerase II transcription factor binding GO:0016879.ligase activity, forming carbon-nitrogen bonds GO:0005102receptor binding GO:0019899enzyme binding GO:0031625 ubiquitin protein ligase binding GO:0044389(small conjugating protein ligase binding GO:0016580 Sin3 complexCellular component GO:0070822Sin3-type complex GO:0034362 low-density lipoprotein particle GO:0044451nucleoplasm part GO:0030669*clathrin-coated endocytic vesicle membrane GO:0034358plasma lipoprotein particle GO:0032994protein-lipid complex GO:0045334!clathrin-coated endocytic vesicle GO:0005876spindle microtubule GO:0000118histone deacetylase complex GO:0005905 coated pit GO:0017053!transcriptional repressor complex GO:0030665 clathrin-coated vesicle membrane GO:0016605PML body GO:0030662coated vesicle membrane GO:0005654 nucleoplasm GO:0030136clathrin-coated vesicle GO:0030666endocytic vesicle membrane GO:0030135coated vesicle GO:0016607 nuclear speck GO:0005770 late endosome GO:0000790nuclear chromatin GO:0030139endocytic vesicle GO:0009897 external side of plasma membrane GO:0005769early endosome GO:0031981 nuclear lumen GO:0005667transcription factor complex GO:0005819spindle GO:0043235receptor complexB* d-T//50`0 1d23G3" 4 j5 [6 U7 >8i 919:;<=E>p?@?@UAB+BCDEXF?GjH9HIJKtL{-M4N NOPPWQQvR}HSOST U V HWO X X YZT[[[\]^>_E_`MaTabBcIcEdLdccc  PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭V6{|Kۡ%C 7Aԅcۅ8T XadwuƝlmM=\('P^Ke#bc{lcw K 6CqKzV"B$L\!ԖovxuF]n# ]L-7Bc".$C΄M\KHt)Z,Kf~߅ .D6K2rA&5B%.lġ-F;`e!(^[>܇jRDsG,oafogBʼn3;J):F ,|BUƮĺ\U1sb!J>3Aq2{u-rRO#G` |q:e_#j=ջԵp[;3E %s@a7e.Wdrf||Fv<'Zz3$vO}|aQSO&!|Tm X#-q&?%2(b:^enh 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