ࡱ> NO  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMRoot Entry F~& t]Ѡt@WorkbookETExtData2SummaryInformation(   ={B@@ Oh+'0@H`p AdministratorAdmin WPS Office@@&t՜.+,D՜.+,HP X`hp x   f2ɀ\pPJMin Ba==XM !8X@"1[SO1Calibri1Calibri1Calibri1Calibri1>Calibri1Calibri1 Calibri1 Calibri1Calibri1Calibri16Calibri1 Calibri1h6Calibri1Calibri1,6Calibri16Calibri1?Calibri14Calibri1 Calibri14Calibri1Calibri1Calibri1<Calibri1[SO1Calibri"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_)+""#,##0;""\-#,##05""#,##0;[Red]""\-#,##07""#,##0.00;""\-#,##0.00A""#,##0.00;[Red]""\-#,##0.00i2_ ""* #,##0_ ;_ ""* \-#,##0_ ;_ ""* "-"_ ;_ @_ .)_ * #,##0_ ;_ * \-#,##0_ ;_ * "-"_ ;_ @_ y:_ ""* #,##0.00_ ;_ ""* \-#,##0.00_ ;_ ""* "-"??_ ;_ @_ 61_ * #,##0.00_ ;_ * \-#,##0.00_ ;_ * "-"??_ ;_ @_ \$#,##0_);\(\$#,##0\)\$#,##0_);[Red]\(\$#,##0\) \$#,##0.00_);\(\$#,##0.00\)% \$#,##0.00_);[Red]\(\$#,##0.00\)                 /    * , /  + , + , /  + 1 9 1 5 7 3 > 9 -   ff7        *  @   @    @ @      / `@ @ +         a@    x  | x x ||Dy1}-} .00\)_ *}-} .00\)_ *}-} .00\)_ *}-} .00\)_ *}A} .00\)_ *ef-#,#}}7 ??v.00\)_ *̙-#,# ;_ -"?? _ }A} .00\)_ *L-#,#}A}( .00\)_ *-#,#}A} .00\)_ *23-#,#}-}6 .00\)_ *}-}0 .00\)_ *}}}:_ *-#,# ;_ -"?? _ }A} _ *23-#,#}-}5 _ *}-}? _ *}-}= _ *}-}/ _ *}A}2 _ *-#,#}A}3 _ *-#,#}A} _ *23-#,#}A}4 _ *?-#,#}A} _ *23-#,#}}; ???_ *-#,#??? ;_ ???-"?? ???_ ???}}) }_ *-#,# ;_ -"?? _ }}* _ *-#,#??? ;_ ???-"?? ???_ ???}A} _ *ef -#,#}A}# _ *-#,#}A}8 }_ *-#,#}U}> _ *-#,# ;_ }A}1 a_ *-#,#}A}9 e_ *-#,#}A} _ *ef-#,#}A}" _ *-#,#}A} _ *ef-#,#}A} _ *L-#,#}A} _ *ef-#,#}A} _ *L-#,#}A}$ _ *-#,#}A}% _ *-#,#}A} _ *ef-#,#}A} _ *L-#,#}A}& _ *-#,#}A} _ *L-#,#}A}  _ *23-#,#}A}' _ * -#,#}A} _ *L -#,#}A}! _ *23 -#,#}-}@ _ *}-}A _ *}-}B _ *}-}C _ * 20% - Accent1M 20% - Accent1 ef % 20% - Accent2M" 20% - Accent2 ef % 20% - Accent3M& 20% - Accent3 ef % 20% - Accent4M* 20% - Accent4 ef % 20% - Accent5M. 20% - Accent5 ef % 20% - Accent6M2 20% - Accent6  ef % 40% - Accent1M 40% - Accent1 L % 40% - Accent2M# 40% - Accent2 L˭ % 40% - Accent3M' 40% - Accent3 L % 40% - Accent4M+ 40% - Accent4 L % 40% - Accent5M/ 40% - Accent5 L % 40% - Accent6M3 40% - Accent6  L % 60% - Accent1M 60% - Accent1 23 % 60% - Accent2M$ 60% - Accent2 23 % 60% - Accent3M( 60% - Accent3 23 % 60% - Accent4M, 60% - Accent4 23f % 60% - Accent5M0 60% - Accent5 23 %! 60% - Accent6M4 60% - Accent6  23Ў % "Accent1AAccent1 [ % #Accent2A!Accent2 }1 % $Accent3A%Accent3  % %Accent4A)Accent4  % &Accent5A-Accent5 Dr % 'Accent6A1Accent6  pG %(Bad9Bad  %) Calculation Calculation  }% * Check Cell Check Cell  %????????? ???+ Comma,( Comma [0]-&Currency.. Currency [0]/Explanatory TextG5Explanatory Text %0 K Followed Hyperlink % 1Good;Good  a%2 Heading 1G Heading 1 DTj%[3 Heading 2G Heading 2 DTj%[4 Heading 3G Heading 3 DTj%?5 Heading 49 Heading 4 DTj%69 Hyperlink % 7InputuInput ̙ ??v% 8 Linked CellK Linked Cell }% 9NeutralANeutral  e%"Normal :Noteb Note   ;OutputwOutput  ???%????????? ???<$Percent =Title1Title DTj% >TotalMTotal %[[? Warning Text? Warning Text %XTableStyleMedium2PivotStyleLight16`jQSheet1Sheet20Sheet34yCategoryTermGenes KEGG_PATHWAYhsa04210 ApoptosisTNF, CASP8, ATM, NGFhsa04010MAPK signaling pathwayEGFR, TNF, EGF, NGFhsa05160 Hepatitis CEGFR, TNF, EGFhsa04068FoxO signaling pathwayEGFR, EGF, ATMhsa05205Proteoglycans in cancerEGFR, TNF, ESR1hsa04015Rap1 signaling pathwayEGFR, EGF, NGFhsa04014Ras signaling pathwayhsa04151PI3K-Akt signaling pathwayhsa05219Bladder cancer EGFR, EGFhsa05200Pathways in cancerEGFR, CASP8, EGFhsa05213Endometrial cancerhsa05134 Legionellosis TNF, CASP8hsa04621#NOD-like receptor signaling pathwayhsa05223Non-small cell lung cancerhsa05212Pancreatic cancerhsa05214Gliomahsa04115p53 signaling pathway CASP8, ATMhsa04622%RIG-I-like receptor signaling pathwayhsa05218Melanomahsa04064NF-kappa B signaling pathwayTNF, ATMhsa04012ErbB signaling pathwayhsa05215Prostate cancerhsa04540 Gap junctionhsa04066HIF-1 signaling pathwayhsa04915Estrogen signaling pathway EGFR, ESR1hsa05231Choline metabolism in cancerhsa05142)Chagas disease (American trypanosomiasis)hsa04620$Toll-like receptor signaling pathwayhsa04668TNF signaling pathwayhsa05145 ToxoplasmosisGOTERM_BP_DIRECT GO:00454298positive regulation of nitric oxide biosynthetic process GO:0000186activation of MAPKK activity GO:0043406*positive regulation of MAP kinase activity GO:0006919Pactivation of cysteine-type endopeptidase activity involved in apoptotic processTNF, CASP8, NGF GO:0048015'phosphatidylinositol-mediated signaling GO:0042981regulation of apoptotic processCASP8, ESR1, ATM GO:0071550)death-inducing signaling complex assembly GO:0000165 MAPK cascade GO:00354132positive regulation of catenin import into nucleus GO:0043065(positive regulation of apoptotic process TNF, ATM, NGF GO:0007165signal transductionEGFR, ESR1, EGF, ATM GO:0060749"mammary gland alveolus development ESR1, EGF GO:0042327&positive regulation of phosphorylation GO:2000145regulation of cell motility GO:0010803>regulation of tumor necrosis factor-mediated signaling pathway GO:0071392'cellular response to estradiol stimulus GO:0042059Inegative regulation of epidermal growth factor receptor signaling pathway GO:00458933positive regulation of transcription, DNA-templatedTNF, ESR1, EGF GO:0008625@extrinsic apoptotic signaling pathway via death domain receptorsTNF, NGF GO:0038128ERBB2 signaling pathway GO:0043124:negative regulation of I-kappaB kinase/NF-kappaB signaling CASP8, ESR1 GO:0097191%extrinsic apoptotic signaling pathway GO:0071230(cellular response to amino acid stimulus EGFR, TNF GO:0008630?intrinsic apoptotic signaling pathway in response to DNA damage GO:0048812neuron projection morphogenesis EGFR, NGF GO:0048146/positive regulation of fibroblast proliferation GO:00071732epidermal growth factor receptor signaling pathway GO:0071407,cellular response to organic cyclic compound GO:00486617positive regulation of smooth muscle cell proliferation GO:0071260(cellular response to mechanical stimulus EGFR, CASP8 GO:00140665regulation of phosphatidylinositol 3-kinase signaling GO:00518971positive regulation of protein kinase B signaling GO:0032355response to estradiol GO:0046854$phosphatidylinositol phosphorylation GO:0007169@transmembrane receptor protein tyrosine kinase signaling pathway GO:0051091Rpositive regulation of sequence-specific DNA binding transcription factor activity TNF, ESR1 GO:0000187activation of MAPK activityTNF, EGF GO:0045944Dpositive regulation of transcription from RNA polymerase II promoter GO:0001934.positive regulation of protein phosphorylation GO:0010629&negative regulation of gene expression GO:0018108!peptidyl-tyrosine phosphorylation GO:0006260DNA replicationEGF, ATM GO:0043123:positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0046777protein autophosphorylation EGFR, ATM GO:0070374,positive regulation of ERK1 and ERK2 cascade GO:0010628&positive regulation of gene expression GO:0007166'cell surface receptor signaling pathwayGOTERM_CC_DIRECT GO:0045121 membrane raftEGFR, TNF, CASP8 GO:0043235receptor complex GO:0016023%cytoplasmic, membrane-bounded vesicleATM, NGF GO:0005615extracellular space GO:0005768endosome GO:0005576extracellular region TNF, EGF, NGFGOTERM_MF_DIRECT GO:0042802identical protein bindingEGFR, TNF, CASP8, ESR1 GO:0030235(nitric-oxide synthase regulator activity GO:0005164&tumor necrosis factor receptor binding GO:0005515protein binding%EGFR, TNF, CASP8, ESR1, EGF, ATM, NGF GO:00469347phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0005088.Ras guanyl-nucleotide exchange factor activity GO:0004713 protein tyrosine kinase activity GO:0008083growth factor activityEGF, NGF GO:0032403protein complex binding GO:0031625 ubiquitin protein ligase bindingWSupplementary Table 1. More details of the KEGG signaling pathways of the core targets.P Value0 {0n 112233(445~617$789 : ;} `<S f=Y q>dE?8?@cAVABpCc)Dccu PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭V&vDJ]jw );ɱ@iKz(H^_6E rW+Rj!-b_$ raBcaiǯ]N4wG.( e)s,~p'T젎KT*"a$. lx$|Q%&U6+ "(&`wOw*(*xNk !KwhLJBv2Q$$G?,FO}Wn0o~>Z2z??}hlG$»O;,񘿙(FIJ@1vޜ#c;x8H xm:L71FwˈhFA5wVj \vclѼMQ*QS,=M1v>!V\H`'>"ΐ*I /sAH{>U𱍄 S+LrjEr8灉 0e^?BlnqX yb#$SCĘi7FII؏JytCwJ7V&e'35̬a2 ^'$=SvĹyVz?(=4Koc-BWhЛJ`~d{B(9ŇB4pN_:qybv2L`"Ǚx N5_9D:^ӷYrYf.xQÍAfky*k.(7!aLfvh-U WVX,.+TjeV7`FpmB*Oy|LReۊvL[$rI&b:yhi˔ZT(X4ZEs v@SS)htvJ&@Yǟ>&ԎP'[D#xHo(Kƅ!עAB$%IW/@S![m %YyA$L1"ϵT_, =oLgkj*!G3$Ve4BvׂqD10k!)8R Mˮsu6R3Ds3-UQ]ӭb 6ˋ5y".KZrN(랣!ԖYuV]ڽc3I\][#:?حV- MJiÅ ?B~?DC}&)eCPK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!&ϟ6theme/theme/theme1.xmlPK-! ѐ'theme/theme/_rels/themeManager.xml.relsPK]  f2ɀ `ju  dMbP?_*+%,&?'?(?)?M*Solid PDF CreatorL 4dA4p MDEP''''otSetMy DocumentsP P d" d ` `? ` `?&`U}  @`,,,,,,,, , , , , ,,,,,,,,,,,,,,,,,,, B @ @ C @ @ @ @A!> @ @ @ @AdM? @ @ @ @ @ Eu? @ @ @ @@ha-u? @ @ @ @@,&? @ @ @ @@]rF? @ @ @ @ @:P;H@? @ @ @ @ @ =tנ? @ @ @ @ @l' ? @ @ @ @ @FG%s? @ @ @ @! @b(˦? @ @ @" @#@4'A? @$ @ @% @&@w? @$ @ @' @(@w? @ @ @) @*@YmD\? @ @ @+ @,@YmD\? @ @ @- @.@  q:6? @/ @ @0 @1@&Ow|? @$ @ @2 @3@1? @ @ @4 @5@Ԇ7)Բ? @6 @ @7 @8@Ԇ7)Բ? @ @ @9 @:@] ? @ @ @; @<@] ? @ @ @= @>@v? @ @ @? @@@v0U? @A @ @B @C@ٵzz? @ @ @D @E@nd͝^? @$ @ @F @G@X"Dȶ? @$ @ @H @I@%f? @$B X8JJJJJJJJJJJJJJJJJJJJJJJJJJJJ ,!,",#,$,%,&,',(,),*,+,,,-,.,/,0,1,2,3,4,5,6,7,8,9,:,;,<,=,>,?, @ @J @K @t4֛? @$ !@L !@M !@N!A? !@ "@L "@O "@P"A gyϪ? "@ #@L #@Q #@R#A(='? #@ $@L $@S $@T$Af6Fl7? $@U %@L %@V %@W%A pC? %@ &@L &@X &@Y&@oMc? &@Z '@L '@[ '@\'@bxdg? '@$ (@L (@] (@^(@6bةl? (@ )@L )@_ )@`)@З0q? )@ *@L *@a *@b*@ r? *@c +@L +@d +@e+@B5M w? +@f ,@L ,@g ,@h,@,g;x? ,@i -@L -@j -@k-@ :? -@ .@L .@l .@m.@OUh? .@ /@L /@n /@o/@ۅ? /@$ 0@L 0@p 0@q0@֤? 0@A 1@L 1@r 1@s1@xA5? 1@ 2@L 2@t 2@u2@A_? 2@v 3@L 3@w 3@x3@`? 3@y 4@L 4@z 4@{4@`? 4@ 5@L 5@| 5@}5@(#? 5@~ 6@L 6@ 6@6@8nN0? 6@$ 7@L 7@ 7@7@cS? 7@ 8@L 8@ 8@8@cS? 8@6 9@L 9@ 9@9@dp? 9@ :@L :@ :@:@+K? :@A ;@L ;@ ;@;@^hR? ;@ <@L <@ <@<@Ff? <@$ =@L =@ =@=@Oj•? =@ >@L >@ >@>@t? >@ ?@L ?@ ?@?@;6? ?@D lJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ@,A,B,C,D,E,F,G,H,I,J,K,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,[,\,],^,_, @@L @@ @@@@Q*w[? @@ A@L A@ A@A@fތ)m? A@~ B@L B@ B@B@? B@ C@L C@ C@C@ɮP? C@ D@L D@ D@D@A? D@ E@L E@ E@E@D? E@ F@L F@ F@F@-G_? F@ G@L G@ G@G@ Tgͦ? G@ H@L H@ H@H@FM? H@ I@L I@ I@I@6S]? I@ J@L J@ J@J@ XVʶ? J@ K@L K@ K@K@mo¬? K@$ L@L L@ L@L@k? L@ M@L M@ M@M@y9w2? M@ N@L N@ N@N@` ? N@y O@L O@ O@O@:? O@ P@ P@ P@P@bZt/? ^@/ _@ _@ _@_@vU? _@D lJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJJ>@dURggD f2ɀ   dMbP?_*+%&?'?(?)?" d ` `? ` `?&`U>@d ggD f2ɀ B  dMbP?_*+%&?'?(?)?" d ` `? ` `?&`U>@d ggD DocumentSummaryInformation8 lCompObjkSheet1Sheet2Sheet3  Worksheetsd ?GKSOProductBuildVer2052-11.1.0.9513 FMicrosoft Excel 2003 WorksheetBiff8Excel.Sheet.89q