Supplementary Table 3. 221 immune-related genes included in the candidate gene set. GS.days_to_BCR GS.biochemical_recurrence MMblack MMblue MMbrown MMturquoise MMpink MMyellow MMgreen MMred MMgrey ANGPT1 0.279958103 -0.091111483 0.506657731 0.453719486 0.796787913 0.853046862 0.371587598 0.656603464 0.587145129 0.553218887 -0.458559506 ANO6 0.216588508 -0.03585442 0.649202021 0.561529618 0.863493579 0.893170748 0.419003406 0.538862488 0.5331463 0.380360225 -0.409891408 STAT5B 0.120149083 -0.037523198 0.671599812 0.514396127 0.803050087 0.744441703 0.375028504 0.406364323 0.475949945 0.420721361 -0.356984082 LPCAT2 0.179469736 -0.025665185 0.648681229 0.631125006 0.80500899 0.686428469 0.429851876 0.331401909 0.639449116 0.604318129 -0.333840851 TGFBR3 0.238236529 -0.057889396 0.54570785 0.583348467 0.845843389 0.912428794 0.494421611 0.632890901 0.626796593 0.490804322 -0.408524979 PIK3R1 0.135549331 -0.057919351 0.745622015 0.485679589 0.830659161 0.637824482 0.216088528 0.232426017 0.389603176 0.408314099 -0.437541791 RARB 0.33138669 -0.047453298 0.521003618 0.593730753 0.827446602 0.785398659 0.381560847 0.517624788 0.637782298 0.599651751 -0.227575153 PLA2G4A 0.214555798 -0.038747002 0.540886861 0.611285049 0.728973975 0.655688108 0.338739505 0.287474499 0.48345599 0.334098119 -0.204335814 NFE2L2 0.147446299 -0.10697809 0.667650878 0.482053388 0.752069699 0.570267557 0.511703191 0.195315597 0.418366654 0.425862408 -0.399288936 RNASEL -0.110516181 -0.007800075 0.619649439 0.563891873 0.781069973 0.611448587 0.303336052 0.297618007 0.534151091 0.50296896 -0.347047409 ITGB1 0.222174391 -0.008566767 0.879160321 0.451557113 0.789955006 0.592478036 0.271052104 0.018334948 0.180514087 0.118665836 -0.428742265 NR3C2 0.162297374 -0.054390767 0.643851647 0.357162005 0.701416169 0.509992347 0.238731475 0.157562524 0.22889124 0.279336679 -0.387575984 PRKCA 0.187611034 0.014418468 0.571806188 0.361701047 0.635931703 0.652618492 0.276913087 0.379502495 0.33617376 0.31940713 -0.279010313 IRAK3 0.390951109 -0.023545682 0.605089413 0.642595473 0.831818616 0.852968956 0.486316286 0.525729036 0.580452039 0.444021184 -0.377217305 PGR 0.169503675 -0.021955774 0.554821228 0.531083412 0.831683699 0.899458557 0.437390957 0.604250014 0.577333255 0.484213993 -0.402777654 EPS8 0.151831895 -0.004330403 0.678995259 0.604914071 0.842261016 0.742332782 0.437355513 0.296602173 0.446001317 0.299741587 -0.253914278 PIAS1 0.235059014 -0.034862045 0.881074239 0.371306365 0.756560476 0.45884561 0.22962782 -0.04078251 0.110847953 0.212519223 -0.52691734 LRRK2 0.230033223 0.019035542 0.654381891 0.711219862 0.861072822 0.842463853 0.462171829 0.453605073 0.563870787 0.387588956 -0.304673702 ITGB3 0.312724551 -0.024205709 0.594229109 0.477652057 0.796472595 0.822470737 0.453281215 0.477085785 0.498315814 0.426191007 -0.40719482 SEMA5A -0.145806432 0.021433478 0.558360307 0.546569819 0.730356089 0.668498693 0.295819842 0.345440327 0.538829538 0.443425003 -0.238716452 PLXNA2 0.224791458 -0.003541341 0.541055528 0.376000429 0.645704898 0.549612547 0.402228719 0.282448518 0.418990648 0.478394191 -0.276983299 CCDC88A 0.261152223 0.000330233 0.698613489 0.732471562 0.877259842 0.793330198 0.423988792 0.387189678 0.567370354 0.403369047 -0.251261987 JAK1 0.247962202 -0.025881136 0.792876462 0.601372646 0.857406718 0.677304731 0.385876999 0.186713704 0.383955052 0.322140624 -0.384568423 ELF1 0.112497213 -0.07319015 0.856885966 0.508332263 0.815722639 0.539538781 0.352164605 0.02923767 0.295908005 0.298680596 -0.434524273 AHR 0.194391784 0.047542584 0.581726473 0.678726634 0.765380425 0.665649063 0.569459793 0.281595886 0.547874197 0.452657964 -0.125446082 JAK2 0.171603251 0.021133787 0.785874657 0.629593014 0.818121317 0.605635086 0.367421446 0.133830888 0.343632917 0.24359226 -0.246935483 IL33 0.301663566 -0.036631054 0.554102516 0.661822609 0.834336356 0.88953169 0.48577403 0.584359769 0.637988288 0.449053377 -0.309398644 ITPR1 0.145821116 -0.016542246 0.605775012 0.265790819 0.583491465 0.501827051 0.249082634 0.186780952 0.222461959 0.205676099 -0.54064623 TGFBR2 0.269439597 0.012677991 0.636856225 0.678144064 0.875771609 0.850190285 0.421855626 0.43921566 0.568551487 0.377553822 -0.268009473 IRAK1BP1 0.119729871 0.039916857 0.573533683 0.193510079 0.433624508 0.322238007 0.115429095 0.040392723 0.114142389 0.177293168 -0.34885243 MAP3K1 0.108643787 -0.026803028 0.814821015 0.57224791 0.746088159 0.450104071 0.271512196 -0.021540562 0.31018211 0.354515809 -0.306408818 LEPR 0.326161061 -0.005431286 0.5987881 0.587643389 0.823880753 0.79401835 0.408877166 0.440947278 0.536296634 0.413251739 -0.372894007 PELI2 0.298535651 -0.010192796 0.575697732 0.415712986 0.650799658 0.514717387 0.286542338 0.178858552 0.364736896 0.351088818 -0.27390601 TCF4 0.252427921 0.018247484 0.653249677 0.69549878 0.849265742 0.81259065 0.43860558 0.395150138 0.550164988 0.361836584 -0.271508216 CRIM1 0.251541969 0.01919267 0.792953641 0.554077399 0.865380993 0.717816918 0.37946526 0.225917032 0.402577792 0.328014405 -0.404163694 IFIT5 -0.15803753 -0.01214357 0.505336238 0.588061716 0.58598204 0.463224207 0.227560769 0.196184255 0.418372624 0.295424965 -0.151304632 IL17RD -0.114362307 0.001278657 0.503803611 0.400079695 0.547084809 0.49228183 0.187613955 0.193079119 0.347398103 0.185418536 -0.204612445 IL6ST 0.229369613 -0.132304719 0.744403038 0.463910791 0.801288125 0.649975518 0.401832239 0.233380961 0.314887213 0.278475836 -0.502006744 EGFR 0.144391057 -0.010936076 0.763731576 0.452407253 0.763065654 0.449770175 0.287504734 -0.008129667 0.303796083 0.430536015 -0.328686583 KDR 0.215855989 0.025386318 0.528945682 0.433424037 0.692799019 0.684348694 0.30608838 0.308920364 0.341917226 0.207541831 -0.238191897 NEDD4 0.313412141 -0.049801204 0.700805466 0.352538005 0.700705776 0.507101756 0.303243652 0.069435141 0.133834535 0.147159206 -0.419126745 REL 0.198206119 -0.035177307 0.822298026 0.502760028 0.723694303 0.418069317 0.51067072 -0.055104525 0.221311535 0.288548657 -0.413936172 SLIT2 0.144877462 -0.008762152 0.533340724 0.45630139 0.656302918 0.673118128 0.329551805 0.322607185 0.277285847 0.096346994 -0.240837536 TNC 0.14203237 -0.008001747 0.500585791 0.590327897 0.72636976 0.723464513 0.410164802 0.452618501 0.63579269 0.530802037 -0.264221603 SERPINB9 0.152250873 -0.013979312 0.571293971 0.884235858 0.77798721 0.739737895 0.631871193 0.418061408 0.711262254 0.478245167 -0.135588699 ATF2 0.149940948 -0.019361801 0.816036745 0.260820938 0.592948898 0.271904692 0.086956932 -0.257387597 -0.04435776 0.003976484 -0.376008454 CCNT1 0.110761335 0.014959021 0.869904517 0.317185125 0.570691625 0.211021759 0.198091332 -0.348138713 -0.037331117 0.040959211 -0.348164538 REST 0.135099973 0.00957693 0.889375426 0.367284745 0.674105182 0.317926089 0.133009368 -0.257260341 0.007247313 0.06870333 -0.397157285 UCN -0.140694099 0.097481355 -0.679885108 -0.249863096 -0.5894522 -0.378703546 -0.276702314 -0.021807635 -0.133914566 -0.1893527 0.672767707 RABEP2 0.216422269 -0.041170024 -0.674907438 -0.463879064 -0.597232582 -0.43264892 -0.351193115 -0.016907628 -0.324304502 -0.256003995 0.259620817 IRF7 -0.316322229 0.063075814 -0.529888617 0.028299044 -0.453474367 -0.335208949 -0.054459957 -0.012539829 0.078263856 -0.031519433 0.593856318 MLST8 -0.101965938 0.044048817 -0.649698388 -0.420091133 -0.725493926 -0.59057762 -0.416604469 -0.245326537 -0.27872845 -0.241670953 0.391316786 NR2F6 -0.150951724 0.040627072 -0.834388157 -0.392542318 -0.733695783 -0.481086826 -0.285871838 0.00254478 -0.165768784 -0.178705874 0.587953633 SHC2 -0.148697401 0.0254364 -0.559155251 -0.284656895 -0.447515071 -0.296855826 -0.130150008 0.032996976 -0.02982686 0.044035442 0.305167278 CORO2A 0.118178333 -0.034475042 0.559781127 -0.034901756 0.230822659 -0.073094318 -0.058564636 -0.409682229 -0.312963014 -0.126697151 -0.3435472 TRIM14 -0.125423 0.137280104 0.516137946 0.260493547 0.219710461 -0.0280631 0.004846647 -0.357369356 -0.021708955 0.0054671 -0.081982473 STAP2 -0.220769363 0.009414204 -0.697809359 -0.238355974 -0.539785523 -0.387622619 -0.226591702 0.047605148 0.013691343 0.017629952 0.384198624 NOXA1 -0.124566884 0.082767462 -0.633457364 -0.216102635 -0.547952507 -0.345581172 -0.171471633 0.057105824 -0.019072677 -0.007485678 0.69819794 TMSB10 -0.166703352 0.077386086 -0.555176296 0.080485565 -0.383916843 -0.136523432 -0.093670722 0.167441961 0.183466186 -0.079968189 0.567866862 TRIM61 0.247962392 -0.030250219 0.265173436 0.440611938 0.522914959 0.672050011 0.215576962 0.538388117 0.460689264 0.287114302 -0.140874591 PAK3 0.164673612 -0.043054977 0.381327798 0.381381654 0.673048814 0.79076918 0.395288602 0.678624974 0.554618465 0.496733884 -0.3671316 SCN5A 0.152261942 0.008154826 0.283490821 0.337433705 0.532424863 0.656701901 0.306387094 0.506926253 0.45545819 0.384401177 -0.125878084 SEMA6D 0.280260875 -0.060205109 0.443425871 0.381371777 0.651152966 0.629748261 0.278110485 0.440660855 0.504771244 0.563220002 -0.239965481 PPARGC1A 0.186192804 -0.117789553 0.29545445 0.275885663 0.596253249 0.643622462 0.352281468 0.610524866 0.504876015 0.586700118 -0.332074522 CALM1 -0.100748609 -0.08949776 0.254093485 0.315488704 0.502008703 0.543529515 0.202465918 0.451459764 0.384100064 0.285041202 -0.168039768 CAV1 0.271423307 -0.091502306 0.294656013 0.417090371 0.682390606 0.878345492 0.433397695 0.813313638 0.665800552 0.538251863 -0.319588293 NRG2 0.234939092 -0.120555991 0.193758133 0.343282765 0.564090595 0.634642685 0.3284709 0.69639774 0.683314009 0.801268742 -0.267703616 DUOX1 0.103942738 -0.088605435 0.243649176 0.337439231 0.540237745 0.479043791 0.391829179 0.489201097 0.670274025 0.89037787 -0.206551718 ADCYAP1R1 0.224741152 -0.07287027 0.328674724 0.378926291 0.550998951 0.662177836 0.36330471 0.539994705 0.42795169 0.332467669 -0.298896767 PRKCB 0.243882922 -0.070670379 0.415104681 0.64007853 0.703904047 0.818781452 0.401642024 0.661075219 0.626225234 0.42442911 -0.284519195 TINAGL1 0.20548571 0.002422523 0.156779109 0.488418745 0.572777054 0.841046971 0.481263271 0.802731769 0.716435706 0.51131371 -0.045520317 ANXA6 0.103169078 -0.042419222 0.164152579 0.554099635 0.570288882 0.820552918 0.409974625 0.852157186 0.785858702 0.527631835 -0.217458695 TRIM6 0.181358797 0.013390971 0.377655836 0.498604996 0.663931812 0.627937741 0.352033496 0.433435032 0.552687306 0.510801971 -0.256555492 TSLP 0.206307338 -0.096213213 0.179059992 0.366296859 0.528758716 0.768734941 0.382397574 0.749102517 0.567528804 0.41703824 -0.191883272 PDGFD 0.19986184 -0.014034827 0.409661743 0.422119185 0.685985495 0.723768919 0.388700419 0.488252915 0.535339168 0.479522121 -0.209006538 GJA1 0.170875514 -0.076018228 0.416724446 0.588537531 0.777084882 0.839417019 0.555310006 0.67144996 0.794637942 0.715587795 -0.293010598 FGFR2 -0.125984903 -0.0382351 0.287599689 0.380493416 0.583070833 0.537237804 0.373145545 0.493034283 0.615773774 0.763787003 -0.253907248 CD200 0.22732762 -0.046721457 0.336536473 0.611490835 0.634204819 0.771650728 0.658614233 0.585423866 0.650724721 0.403617184 -0.052050455 ILK 0.241413783 0.004651491 0.4656713 0.419283546 0.686081636 0.734504732 0.323254262 0.484577763 0.459265395 0.366633828 -0.306298922 FZD1 0.278729718 -0.024354342 0.47797255 0.312468756 0.679194532 0.594035319 0.206359074 0.342381664 0.366245816 0.412764954 -0.353026206 NRG1 0.185231496 -0.091254143 0.342783735 0.386239548 0.6039301 0.536253344 0.426229948 0.43741274 0.591453252 0.754143343 -0.246128729 KCNJ8 0.128612708 -0.004482272 0.176023707 0.5074981 0.596060873 0.849270762 0.400708988 0.835449361 0.732932423 0.512317594 -0.18187262 EDNRA 0.106351512 0.006350603 0.45039862 0.559429709 0.779943837 0.894605919 0.402296996 0.670075936 0.669342317 0.499711497 -0.339576502 FGF7 0.279310783 0.012136602 0.255031815 0.423335364 0.555082333 0.732814543 0.329431094 0.595815587 0.463700729 0.272730103 -0.182654057 ANGPTL1 0.267250231 -0.075012058 0.254186536 0.290007233 0.544479771 0.757951652 0.320263121 0.716175356 0.434830085 0.287811416 -0.356334901 SEMA3A 0.277517321 -0.080441205 0.386234514 0.437100728 0.632774376 0.737327072 0.339454503 0.556122774 0.455893291 0.323989614 -0.319293976 BDNF 0.287254561 -0.010050171 0.256389672 0.36208561 0.519115562 0.673927273 0.400540639 0.537324468 0.533746357 0.441213798 -0.093737092 FGF10 0.309799899 -0.052328217 0.481039959 0.465150918 0.739042896 0.80527832 0.380045938 0.552443949 0.522289325 0.450158898 -0.403588534 PDGFC 0.178967173 -0.039102733 0.426023773 0.570796902 0.763933911 0.84476004 0.388926973 0.653138334 0.677623271 0.543833989 -0.342143498 FGF2 0.313540819 -0.057021391 0.433243011 0.50283859 0.736574887 0.863989398 0.457720853 0.644414679 0.58006252 0.424094414 -0.320746377 NLRP14 0.17521983 -0.117831691 0.328425718 0.353393107 0.529701672 0.417821534 0.298304233 0.292567717 0.440596485 0.564244815 -0.210935246 NRP2 0.171396053 0.059263937 0.406481252 0.579635136 0.67518246 0.860463117 0.41104728 0.584782933 0.579161227 0.26433272 -0.119215833 EDNRB 0.386668082 -0.098416739 0.351570643 0.290212856 0.562086382 0.69922221 0.330416825 0.496413265 0.310650259 0.151264466 -0.256688497 FGFR1 0.220783248 -0.025252363 0.340986394 0.479391061 0.65958213 0.877333736 0.39902518 0.714495686 0.581240723 0.381111149 -0.165231562 MET 0.120880798 0.001771075 0.487965627 0.661849961 0.774376917 0.700733312 0.506402239 0.464022448 0.771084264 0.787209737 -0.217863521 TLR2 0.122227315 0.036596052 0.417344749 0.835280744 0.664264581 0.612811976 0.506976441 0.374772652 0.763096956 0.621207322 -0.054903897 SDC3 -0.117310413 0.074377044 0.373539723 0.573134985 0.634416319 0.789148984 0.333169391 0.575362975 0.636849272 0.387898539 -0.104691823 MASP1 0.214947052 -0.023513584 0.259264156 0.369329985 0.594881158 0.820395669 0.33585746 0.718914669 0.545213645 0.401258161 -0.27256917 STAT5A 0.184516679 -0.041481046 0.152083402 0.716263054 0.549475044 0.679694084 0.465963559 0.693218368 0.851345778 0.636219394 -0.030884149 MAP3K12 0.192710759 0.116899204 0.35229747 0.626584977 0.59057008 0.734478223 0.408240675 0.518669168 0.616233278 0.389034655 0.180375208 CFH 0.225012128 0.009606709 0.424507329 0.714358229 0.745802133 0.837715617 0.518530362 0.603676144 0.727152789 0.528108522 -0.124930419 GRK5 0.24865994 0.045342784 0.332037452 0.589116661 0.649521957 0.861823603 0.443061402 0.716108247 0.664180009 0.402944041 -0.154455552 IFI16 0.181853479 -0.036527506 0.450313227 0.862292668 0.765814289 0.774327536 0.568847523 0.527395047 0.843067637 0.630865215 -0.062862046 EDIL3 0.291124094 0.040485467 0.414504734 0.514070979 0.655202164 0.829237431 0.325377097 0.543273998 0.472132777 0.172043604 -0.169143166 GDF7 0.141399763 0.031357483 0.445855397 0.495406987 0.633188154 0.658231044 0.361090107 0.416294151 0.567567482 0.513286525 -0.166459589 IL18R1 0.110165077 0.011130018 0.342222922 0.656974559 0.529548875 0.504260219 0.358028941 0.296549582 0.526412676 0.35090733 0.048032058 OGN 0.221182778 -0.066408899 0.378000075 0.447161563 0.694303434 0.848476224 0.352214337 0.716693736 0.568529865 0.424232825 -0.396926171 DCN 0.236291891 -0.005987524 0.286253734 0.516577868 0.569594154 0.79894016 0.344278829 0.625897579 0.493693096 0.150296169 -0.132445632 AXL 0.105738813 0.026522934 0.419098145 0.747753835 0.76957083 0.875122263 0.502831192 0.651883713 0.817881933 0.585012666 -0.13908624 CX3CL1 0.147637308 -0.100361348 0.220213148 0.613996219 0.614043244 0.729709617 0.689288035 0.697925651 0.835022668 0.751368815 -0.157922696 BMP4 0.174216072 0.047735984 0.300596758 0.513133881 0.621164248 0.788698165 0.284684862 0.585445017 0.548065755 0.33538399 -0.094598771 NOD2 0.140257596 0.056628949 0.320843716 0.692455142 0.545479984 0.461264312 0.372661153 0.295707613 0.579186531 0.457766918 0.015929707 NFATC2 0.202272812 -0.05840176 0.399359519 0.653276444 0.552744384 0.517980792 0.545603016 0.307263028 0.560896906 0.374333934 -0.054704899 CCL28 -0.225490193 -0.063336045 0.440996483 0.503815691 0.543539484 0.417115682 0.301736288 0.2269645 0.521651286 0.536861852 -0.24989751 C7 0.210917176 -0.09001663 0.330898731 0.44832614 0.621997719 0.77693034 0.392569892 0.635537692 0.488590371 0.308440697 -0.328223881 ANGPTL2 0.170234891 0.071488694 0.348050255 0.468498247 0.532685673 0.654221212 0.324213477 0.469624913 0.567267492 0.3896241 -0.104574607 MAP3K8 0.129304691 0.039405037 0.371753783 0.653518799 0.542212369 0.563324233 0.815979865 0.368393227 0.629287473 0.489960406 0.00420568 SERPING1 0.128099715 -0.022622 0.152176373 0.693123338 0.566141729 0.805487923 0.461527427 0.767564849 0.823835121 0.495818509 -0.084865005 HLA-DOA 0.109024342 0.035289302 0.382807372 0.889673635 0.66645477 0.645858169 0.426812497 0.449239069 0.797996959 0.589571053 -0.024901184 IL6R 0.137442834 -0.058601867 0.387998684 0.389595935 0.546676328 0.38968749 0.356379814 0.179600999 0.373777016 0.417733329 -0.22933082 P2RY14 0.193430374 0.054336347 0.446751598 0.752140979 0.571847371 0.55719798 0.323396053 0.268353779 0.483821675 0.174869764 -0.053330624 PLCG2 0.21656321 0.034856513 0.43436633 0.85747521 0.674545627 0.700590937 0.45048159 0.430234593 0.679646348 0.379473732 0.018794945 AVPR1A 0.101075282 0.06286139 0.438243674 0.349463045 0.615199283 0.678288407 0.41622167 0.396985926 0.316471641 0.200477636 -0.27836722 SEMA3C 0.462075503 -0.045702829 0.383461466 0.172323909 0.500915537 0.424531816 0.209820172 0.213041488 0.103352542 0.168158333 -0.328016371 IFIT2 -0.197113168 0.090400168 0.411221017 0.668623651 0.508542916 0.422921002 0.153740239 0.162281807 0.447010516 0.212153128 0.048580165 TGFA -0.107585241 -0.067363985 0.373981686 0.422968875 0.531528049 0.377177867 0.313439743 0.159688849 0.439255335 0.410406785 -0.25392495 SIGLEC6 0.133948253 -0.00586287 0.447610299 0.468756507 0.572191647 0.503697855 0.239463077 0.195206462 0.272064445 0.180836439 -0.181060768 TNFSF15 0.240193329 -0.035557675 0.380857173 0.471641684 0.524043715 0.374344264 0.34832286 0.150568708 0.399121697 0.428739723 -0.164848005 CFTR 0.159087222 -0.042946318 0.373106148 0.525223737 0.552748244 0.39789789 0.515670783 0.24818431 0.607879702 0.774107685 -0.211946589 TOR2A -0.326808061 0.006638842 -0.442449579 -0.296026489 -0.585807636 -0.550960113 -0.326559533 -0.322759916 -0.29375255 -0.268598866 0.320601174 TRIM9 0.328070194 -0.022437079 0.236166686 0.338269565 0.494863067 0.705597146 0.317158071 0.599881258 0.432755113 0.258491558 -0.117029815 LGR6 0.240631147 -0.115095324 0.10648854 0.232072538 0.446580516 0.665913308 0.305693353 0.744259158 0.501715902 0.449898142 -0.178644967 CSRP1 0.24727725 -0.106970479 -0.021173024 0.2340373 0.405686106 0.688219951 0.367048219 0.867155475 0.623005326 0.54148466 -0.284474649 CNTFR 0.194598104 -0.077114436 0.073428746 0.182829314 0.354864624 0.602259279 0.21220008 0.681554598 0.383639437 0.263899123 -0.13965596 CMTM5 0.19875023 -0.0391837 -0.142728492 0.147420347 0.211485351 0.549110274 0.24714085 0.808000861 0.447126313 0.27351622 -0.052069944 PGF 0.234094766 -0.058479448 -0.09221742 0.273093304 0.245363984 0.56774018 0.26945623 0.726762796 0.499128684 0.269143504 0.038414849 NDP 0.170731936 -0.075046826 0.08222813 0.226358557 0.424133725 0.690920587 0.208468778 0.767403423 0.451471512 0.307562395 -0.277605808 NTF3 0.365991308 -0.064437718 0.089924329 0.213065713 0.399516272 0.55307314 0.444973364 0.662750845 0.549016379 0.571572008 -0.202611632 SSTR2 0.280015104 -0.050566264 0.074879659 0.378461972 0.402663796 0.677190919 0.424943949 0.730646049 0.562761758 0.341304843 -0.06824892 MPO 0.190722271 -0.038620237 0.087700358 0.423311215 0.389907064 0.585910286 0.33367904 0.660853977 0.53683718 0.327072737 -0.124626704 EDN3 0.14514229 -0.140871654 0.099765395 0.149771038 0.378346307 0.5129622 0.170773255 0.604723604 0.405300904 0.429991933 -0.285954104 GAS6 0.162166815 0.02697141 -0.054703644 0.488152228 0.410369427 0.748689054 0.362269225 0.842745198 0.779581386 0.512982764 0.117030614 DES 0.207771563 -0.091221491 -0.106690517 0.212274786 0.32164252 0.649154701 0.341870155 0.877944923 0.609990181 0.484508513 -0.220114633 PTGER3 0.335037492 0.032926637 0.301640398 0.311727681 0.483231688 0.612147555 0.266069469 0.419442044 0.330990626 0.145947812 -0.259126491 TPM2 0.145177051 -0.062102194 -0.243410298 0.194397331 0.217684792 0.606932131 0.29775993 0.913317162 0.617093202 0.444932491 -0.090115434 WNT2B 0.124349946 0.013653184 0.285438101 0.376838299 0.483522897 0.653205934 0.245887404 0.485857325 0.398768976 0.178165757 -0.072846838 JAM3 0.355854053 -0.111913062 0.022634091 0.26242526 0.423408314 0.65070189 0.297852394 0.731167879 0.456113657 0.316921571 -0.18672524 PTGDS 0.170675368 -0.078477942 -0.049547839 0.355102298 0.352305062 0.599959231 0.311462138 0.785799801 0.650176225 0.529340151 -0.184169638 NFATC4 0.296158928 -0.004947108 -0.06931687 0.396448892 0.370276615 0.690920498 0.440685664 0.838645754 0.712409735 0.542222541 0.066379156 TGFB3 0.138342401 -0.050372438 0.139543537 0.272335882 0.442023286 0.570551059 0.297974998 0.555112535 0.474724524 0.421597667 -0.169752194 NGFR 0.148634709 -0.051336608 0.093514242 0.424351103 0.459073015 0.549862467 0.422410415 0.600750431 0.727425528 0.7056936 -0.083735042 PROCR 0.19983565 -0.01066232 0.144137102 0.442833112 0.394469853 0.522679134 0.279690523 0.485731254 0.580383601 0.370507813 0.018381095 BDKRB2 0.199199273 -0.019170677 0.218480035 0.517245595 0.485047578 0.594873911 0.814263438 0.497621344 0.611103866 0.480619545 -0.045039935 NPR1 0.23580177 0.015998408 0.055485833 0.389488338 0.3918952 0.631719529 0.357553077 0.597202927 0.530181925 0.290131958 0.057723948 TRAF5 -0.108551489 0.09841697 0.292984313 0.64166358 0.492149133 0.559668031 0.318619086 0.394698475 0.583342161 0.335513024 0.180808965 IGF2 0.390980543 0.039184844 0.124627263 0.373708759 0.414542447 0.697323717 0.280409221 0.634955328 0.437046746 0.122052205 -0.035152658 NLRP1 0.144220317 0.041086404 0.085359146 0.659963333 0.495503655 0.752065099 0.44346012 0.760367143 0.805640919 0.523609319 0.148056881 PTH1R 0.193958839 -0.032584769 -0.171438745 0.283541929 0.255593452 0.636545725 0.270921626 0.831501737 0.57034805 0.33368027 0.026284942 RARRES2 0.119710963 -0.024673838 -0.290202416 0.362884792 0.21114417 0.614803127 0.323270723 0.912377177 0.727605259 0.475934537 0.083848918 CCL21 0.133529974 0.060193146 0.043135724 0.51124383 0.328660056 0.514864261 0.271178427 0.552002754 0.635920744 0.36793681 0.000111548 CCL14 0.238326318 -0.006096985 -0.066500544 0.33542969 0.288685336 0.524610693 0.299692417 0.623243466 0.499054617 0.298139118 -0.033893312 IL1R2 0.220866078 -0.021905044 0.080672751 0.490436373 0.37478584 0.493994451 0.433438558 0.506904164 0.619352358 0.480309983 0.071243859 GDF10 0.313435509 -0.081397733 0.012832317 0.123785441 0.252440893 0.478084955 0.176911013 0.606431066 0.295576334 0.167057636 -0.123916249 SLC22A17 0.136190015 -0.129153768 -0.048783882 0.098213868 0.314650028 0.451824996 0.220867996 0.659059625 0.508288435 0.607128489 -0.235298758 S100B 0.113953265 0.001843417 -0.131480295 0.309877562 0.194829996 0.427183731 0.312869127 0.646653845 0.550846299 0.387775537 0.051308286 USP2 0.15783099 -0.036395844 0.048413121 0.258886206 0.308789872 0.490942668 0.515376152 0.595986492 0.450827482 0.317306473 -0.057703039 SEMA3B 0.107088579 0.055131425 -0.310826297 0.185349328 0.078453899 0.402585769 0.242847002 0.677500155 0.496220033 0.371493422 0.383330657 WNT3A 0.17743765 -0.093454448 0.018288428 0.257355024 0.352391848 0.359439188 0.305722085 0.526744794 0.670109212 0.877168463 -0.113917267 PYCARD -0.18143056 0.02696475 -0.225984627 0.438560151 0.141885741 0.32867885 0.250444768 0.601272687 0.776376046 0.653933185 0.115919257 LCN6 0.306815663 -0.049548804 -0.234301053 0.163212729 0.117122361 0.405416568 0.291018547 0.644435815 0.411598752 0.249778585 0.058021472 IL17B 0.122616773 0.040612565 -0.389874809 0.133717637 -0.004646944 0.338477438 0.199528148 0.712946854 0.539468649 0.395406213 0.172043813 ELANE 0.193289162 -0.047162331 -0.187699125 0.199689161 0.168853232 0.476359197 0.251642184 0.72731811 0.474476054 0.338837044 -0.009367319 VAV2 -0.16851037 0.157670764 0.169355103 -0.018731291 -0.115114527 -0.264687682 -0.181559132 -0.517500197 -0.302086609 -0.290802411 0.314398171 PPP3CA -0.157155048 0.104271132 0.320379261 -0.179438934 0.003103904 -0.223880313 -0.16657615 -0.511211154 -0.434703163 -0.329003247 -0.215247676 PTGS2 0.167513323 -0.139426681 0.383377434 0.324340398 0.45484867 0.356925461 0.678054791 0.193873475 0.379613001 0.45070322 -0.311558684 IL1RL1 0.26215349 -0.045394623 0.194855147 0.300541667 0.354336801 0.424052509 0.572890934 0.301414128 0.296879251 0.187020273 -0.076903115 TNFRSF10D 0.175648643 -0.178646635 0.246274546 0.296448633 0.446099738 0.442828828 0.618786083 0.399027162 0.471464758 0.509113982 -0.273930985 IL1RN -0.134463551 -0.102041328 0.210825227 0.494640052 0.369865686 0.332277914 0.633507348 0.248907905 0.527932808 0.466276756 0.051149363 IL20 0.145466001 -0.081485235 0.134472035 0.26693011 0.225520072 0.204025695 0.653856999 0.143119679 0.326842468 0.34349811 -0.007582854 BMP2 -0.102677223 0.056832685 0.345371358 0.408835442 0.437097843 0.394896275 0.501891222 0.213992177 0.456124592 0.43120724 -0.092359658 NR4A3 0.262772361 -0.073340675 0.214460923 0.259582962 0.316177199 0.354995753 0.834605079 0.279505307 0.296870649 0.237376419 -0.163364413 S100A8 0.130532546 -0.102135579 0.034105593 0.384127609 0.259486981 0.293746972 0.513458771 0.331395619 0.446407858 0.388005112 -0.108837195 DUSP1 0.182177542 -0.044220189 0.291556155 0.276863554 0.384674902 0.389284473 0.672275505 0.311622342 0.339498856 0.3376083 -0.326835983 DKK1 0.166209395 -0.027308283 0.17387348 0.435201479 0.415558655 0.456196733 0.643669627 0.352737317 0.580637363 0.550544478 0.031707581 ATF3 0.197014491 -0.138310326 0.176447372 0.245138159 0.255469195 0.247750955 0.85292784 0.20365829 0.274778294 0.253128326 -0.13754258 CSF3 0.21355654 -0.062979008 -0.009672699 0.162559022 0.143921617 0.26960882 0.686889896 0.349737719 0.286798539 0.227972447 -0.037585277 SOCS3 0.275318286 -0.121251326 0.20039753 0.434473969 0.400266185 0.485147512 0.906541468 0.429827253 0.501068498 0.37691281 -0.150018171 FOS 0.243221079 -0.104925013 0.251469352 0.268173821 0.340881 0.329468391 0.773570511 0.269403419 0.307971855 0.313516589 -0.269331041 EDN2 0.223914836 -0.089879885 0.080284731 0.310490161 0.236299406 0.212196929 0.539312111 0.189266606 0.44203063 0.487062253 0.065765466 EDN1 0.236294358 -0.075366641 0.305255759 0.430126637 0.447084818 0.359288462 0.607773336 0.206557935 0.474264945 0.464828576 -0.074665215 HBEGF 0.363915351 -0.093137769 0.088500223 0.229028803 0.295800292 0.352313328 0.814966864 0.340939496 0.309047048 0.295306966 -0.121531106 SELE 0.277133461 -0.096247484 0.249252408 0.348579315 0.393808593 0.448059731 0.839101717 0.342899875 0.357225461 0.265818523 -0.17246582 EGR1 0.2535682 -0.135722361 0.27874497 0.298205111 0.381801489 0.369070021 0.809182282 0.26430134 0.296486796 0.279428003 -0.25639333 IL1B 0.100875462 -0.066826003 0.306384398 0.518460767 0.438289001 0.386731997 0.797826416 0.240532864 0.47303179 0.432024938 -0.085036142 AREG 0.221235209 -0.054335115 0.145561482 0.316705796 0.320434945 0.337839724 0.8236472 0.290483011 0.402862535 0.393580618 -0.077629534 IL6 0.270035397 -0.047242119 0.119743748 0.292268683 0.263219636 0.36324318 0.861892787 0.331795753 0.343850774 0.235495497 -0.062584343 CXCL2 0.146271837 -0.07690404 0.16858526 0.42719292 0.338011673 0.31201358 0.773991873 0.289594085 0.500304745 0.560846088 -0.103015014 SERPINA3 0.217213358 -0.089023595 0.14771807 0.262579877 0.211589703 0.131345201 0.534865413 0.073739818 0.252078281 0.312460461 -0.154901647 BIRC5 -0.169555589 0.198762531 -0.158354312 0.079736063 -0.294702087 -0.281227464 -0.213359864 -0.340747717 -0.127008544 -0.274413229 0.606307794 PLK1 -0.17697947 0.224677821 0.066900322 0.218322432 -0.091957219 -0.166406374 -0.156131039 -0.353306777 -0.054925042 -0.186164732 0.561895656 AMH -0.294112912 0.147234872 -0.180475756 0.06371667 -0.230086789 -0.172802527 -0.15474111 -0.147914452 -0.026297047 -0.139753403 0.671574116 YJEFN3 -0.175474072 0.139230023 -0.352279304 -0.034104004 -0.309641025 -0.193743283 -0.096292603 0.008874653 0.021333442 0.021429215 0.713740817 VGF -0.11266192 0.126505849 -0.337017365 0.01684327 -0.249434028 -0.060661164 -0.035889631 0.085274775 0.062217057 -0.080761046 0.612435093 WDR62 -0.167963068 0.144362789 -0.078063833 0.11228243 -0.162192506 -0.132699041 -0.114942405 -0.142188802 -0.068466374 -0.234988988 0.515875441 E2F1 -0.161467439 0.168099611 -0.228219172 0.011493561 -0.310570206 -0.261881283 -0.235133726 -0.239162726 -0.104904808 -0.228291984 0.629559177 TNFRSF18 -0.156519298 0.093481548 -0.408363954 0.208086055 -0.290832576 -0.124002792 -0.004167412 0.125192328 0.308137548 0.145717172 0.555686406 INHA -0.11413136 0.085059273 -0.363601024 -0.078537272 -0.321582914 -0.178287128 -0.179456162 -0.000417872 -0.020790625 -0.047700965 0.667028414 FGF17 -0.102264691 0.05032056 -0.281159793 0.058941086 -0.118317739 -0.03073174 0.045330706 0.166592463 0.23748316 0.295251071 0.567195583 GPSM1 -0.08853426 0.179086574 -0.255805456 -0.139172836 -0.359588162 -0.183863971 -0.164549115 -0.107395045 -0.14974425 -0.213629367 0.513367573 PDIA2 0.016010654 0.165939278 -0.254006812 -0.05041159 -0.292026082 -0.213384174 -0.168082543 -0.136893019 -0.07222742 -0.133907247 0.560594359 PACSIN1 -0.028246581 0.145827917 -0.093943773 0.057669196 -0.129936822 -0.145729076 -0.153711884 -0.138803028 -0.056185873 -0.111972236 0.562355863 WFIKKN1 -0.067559278 0.150600623 -0.195615845 -0.037906543 -0.19485848 -0.155025599 -0.152069118 -0.051316907 -0.030632634 -0.014282316 0.505357446 MC1R -0.087826584 0.124505623 -0.216634653 0.113360537 -0.100254599 -0.045394269 0.032448278 0.049144952 0.131489277 0.117337724 0.640924538 CHP2 0.055160893 -0.114960318 0.109516405 0.218070887 0.378411281 0.325479742 0.319781036 0.409786714 0.571602382 0.833335021 -0.176764981 S100A14 -0.029475548 -0.104174281 -0.009263412 0.350677417 0.353670627 0.388623905 0.401544593 0.559701177 0.752157397 0.918773436 -0.068510922 WFDC2 0.025911854 -0.125108753 -0.05229423 0.321341689 0.327149876 0.423014462 0.415631102 0.63251243 0.725095746 0.841392506 -0.20078693 LGALS3 0.052146546 -0.111520957 0.085315968 0.364881003 0.408136932 0.471736159 0.379646608 0.543917152 0.590874332 0.545563061 -0.157768958 TP63 0.055792138 -0.111087892 0.370663821 0.409686502 0.640399158 0.520177107 0.378844925 0.439200387 0.67094415 0.895522665 -0.314511875 DEFB1 -0.050372814 -0.108990874 -0.09503295 0.286500864 0.234363103 0.280143158 0.356285587 0.449504137 0.664278944 0.781762822 -0.00207768 OLFM4 0.130513754 -0.119373639 0.195551256 0.385951015 0.43825469 0.33849439 0.410850816 0.311951418 0.602233487 0.830606672 -0.214443734 LCN2 -0.026376947 -0.155987923 0.026822091 0.335898307 0.279991763 0.244787746 0.389439625 0.334452554 0.532160275 0.66123621 -0.153990032