ࡱ> npm_ bjbj,E,E 2~N/N/ """8Z4L"G(6b$$ l664JJJ(JJJJ0E6J0GJ1!1!J1!JhJG1! : Supplementary Table 1. MOOSE Checklist. MOOSE Checklist Coagulopathy in patients with Coronavirus Disease 2019(COVID-19):a systematic review and meta-analysis Xiaolin Zhang*, Xue Yang*, Hongmei Jiao, Xinmin Liu Department of Geriatrics, Peking University First Hospital *These authors contributed equally to this work Corresponding Author : XinMin Liu Peking University First Hospital, Beijing 100034, China Tel: +86-10-66110802 Fax: +86-10-66110802 E-mail: lxmgeriatric@126.com CriteriaBrief description of how the criteria were handled in the meta-analysisReporting of background should include(Problem definitionCOVID-19 is associated with coagulopathy and a significant increased risk of thrombotic events. This meta-analysis aimed to explore coagulopathy on severity differences in patients with COVID-19.(Hypothesis statementCoagulation dysfunction was associated with severity of COVID-19.(Description of study outcomesThe severity of patients with COVID-19.(Type of exposure or intervention usedMore severe patients with COVID-19.(Type of study designs usedWe included original studies including observational study, case-control studies, cohort studies and randomized control studies(Study populationAdult patients with COVID-19.Reporting of search strategy should include(Qualifications of searchersThe literature search was carried out independently by two investigators Xiaolin Zhang and Xue Yang.(Search strategy, including time period included in the synthesis and keywordsWe searched the electronic databased Pubmed, Embase, Cochrane, WanFang Database, CNKI, and medRxiv from December1,2019 to May 1,2020 using a combination of the following key words:"Covid-19" or "2019 novel coronavirus infection" or "SARS-CoV-2and characteristics or coagulopathy or coagulation.(Databases and registries searchedPubmed, Embase, Cochrane, WanFang Database, CNKI, and medRxiv(Search software used, name and version, including special featuresWe did not employ a search software. EndNote was used to merge retrieved citations and eliminate duplications.(Use of hand searchingWe hand-searched bibliographies of retrieved papers for additional references.(List of citations located and those excluded, including justificationsDetails of the literature search process are outlined in the flow chart. The citation list is available upon request.(Method of addressing articles published in languages other than EnglishThe language of literature included English and Chinese. We translated the Chinese literatures into English version.(Method of handling abstracts and unpublished studiesWe had contacted a few authors for unpublished studies on the association.(Description of any contact with authorsWe contacted authors who had conducted analysis of clinical characteristics of COVID-19, but they had not reported coagulation dysfunction.Reporting of methods should include(Description of relevance or appropriateness of studies assembled for assessing the hypothesis to be testedDetailed inclusion and exclusion criteria were described in the methods section. (Rationale for the selection and coding of dataData items extracted from each study included study characteristics, demographic information, and outcomes of interest.(Assessment of confoundingThere were strict inclusion criteria. Studies of low quality were excluded.(Assessment of study quality, including blinding of quality assessors; stratification or regression on possible predictors of study resultsWe used the Newcastle-Ottawa scale (NOS),which includes patients selection, study comparability and outcomes assessment three components to evaluate the quality of the original study. Articles of low quality (NOS<5) were excluded from the meta-analysis.(Assessment of heterogeneityHeterogenity among the studies was assessed by the Chi squared and I2 tests.(Description of statistical methods in sufficient detail to be replicatedDescription of methods of meta-analyses, subgroup analysis and assessment of publication bias are detailed in the methods.(Provision of appropriate tables and graphicsWe included flow chart detailing the terms used for database search, summary table of included studies, summary table of meta-analysis and subgroup analysis, forest plot of all studies, funnel and Eggers test diagram of all studies.Reporting of results should include(Graph summarizing individual study estimates and overall estimateFigure 2(Table giving descriptive information for each study includedTable 1(Results of sensitivity testing Table 2(Indication of statistical uncertainty of findings95% confidence intervals were presented with all summary estimates, I2 values and results of sensitivity analysesReporting of discussion should include(Quantitative assessment of biasHeterogeneity in strengths of the association due to most common biases in observational studies. (Justification for exclusionWe excluded the studies with low quality. 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