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Warning Text %XTableStyleMedium2PivotStyleLight16`e5Supplementary Table 4S D(##Databases: KEGG PATHWAY, Gene OntologyD##Statistical test method: hypergeometric test / Fisher's exact test/##FDR correction method: Benjamini and Hochberg#TermDatabaseID Input numberBackground numberP-ValueCorrected P-ValueInput Hyperlink Th1 and Th2 cell differentiation KEGG PATHWAYhsa04658,IL2RB|STAT4|TBX21|CD3E|RUNX3|CD247|ZAP70|LCKhttp://www.genome.jp/kegg-bin/show_pathway?hsa04658/hsa:919%09red/hsa:6775%09red/hsa:7535%09red/hsa:916%09red/hsa:3560%09red/hsa:30009%09red/hsa:864%09red/hsa:3932%09red)Natural killer cell mediated cytotoxicityhsa04650,GZMB|SH2D1B|NCR3|KLRK1|CD247|FASLG|ZAP70|LCKhttp://www.genome.jp/kegg-bin/show_pathway?hsa04650/hsa:919%09red/hsa:7535%09red/hsa:3932%09red/hsa:22914%09red/hsa:259197%09red/hsa:3002%09red/hsa:356%09red/hsa:117157%09redTh17 cell differentiationhsa04659&IL2RB|TBX21|IL21R|CD3E|CD247|ZAP70|LCKhttp://www.genome.jp/kegg-bin/show_pathway?hsa04659/hsa:919%09red/hsa:7535%09red/hsa:3560%09red/hsa:30009%09red/hsa:916%09red/hsa:3932%09red/hsa:50615%09red!T cell receptor signaling pathwayhsa04660CD3E|CARD11|CD247|ZAP70|LCK}http://www.genome.jp/kegg-bin/show_pathway?hsa04660/hsa:84433%09red/hsa:919%09red/hsa:916%09red/hsa:7535%09red/hsa:3932%09red6PD-L1 expression and PD-1 checkpoint pathway in cancerhsa05235CD3E|CD247|ZAP70|LCKmhttp://www.genome.jp/kegg-bin/show_pathway?hsa05235/hsa:3932%09red/hsa:919%09red/hsa:916%09red/hsa:7535%09redNF-kappa B signaling pathwayhsa04064CARD11|ZAP70|CCL4|LCKphttp://www.genome.jp/kegg-bin/show_pathway?hsa04064/hsa:84433%09red/hsa:6351%09red/hsa:7535%09red/hsa:3932%09red)Chagas disease (American trypanosomiasis)hsa05142CD247|FASLG|CD3E|PPP2R2Blhttp://www.genome.jp/kegg-bin/show_pathway?hsa05142/hsa:919%09red/hsa:5521%09red/hsa:916%09red/hsa:356%09redPrimary immunodeficiencyhsa05340CD3E|ZAP70|LCK_http://www.genome.jp/kegg-bin/show_pathway?hsa05340/hsa:3932%09red/hsa:916%09red/hsa:7535%09red Inflammatory bowel disease (IBD)hsa05321TBX21|IL21R|STAT4bhttp://www.genome.jp/kegg-bin/show_pathway?hsa05321/hsa:6775%09red/hsa:30009%09red/hsa:50615%09red&Cytokine-cytokine receptor interactionhsa04060IL2RB|IL21R|FASLG|CCL4ohttp://www.genome.jp/kegg-bin/show_pathway?hsa04060/hsa:3560%09red/hsa:6351%09red/hsa:50615%09red/hsa:356%09redMeasleshsa05162IL2RB|FASLG|CD3E^http://www.genome.jp/kegg-bin/show_pathway?hsa05162/hsa:3560%09red/hsa:916%09red/hsa:356%09redJak-STAT signaling pathwayhsa04630IL21R|IL2RB|STAT4ahttp://www.genome.jp/kegg-bin/show_pathway?hsa04630/hsa:3560%09red/hsa:6775%09red/hsa:50615%09redAllograft rejectionhsa05330 FASLG|GZMBPhttp://www.genome.jp/kegg-bin/show_pathway?hsa05330/hsa:3002%09red/hsa:356%09redGraft-versus-host diseasehsa05332Phttp://www.genome.jp/kegg-bin/show_pathway?hsa05332/hsa:3002%09red/hsa:356%09redEpstein-Barr virus infectionhsa05169RUNX3|CD247|CD3E]http://www.genome.jp/kegg-bin/show_pathway?hsa05169/hsa:919%09red/hsa:916%09red/hsa:864%09redType I diabetes mellitushsa04940Phttp://www.genome.jp/kegg-bin/show_pathway?hsa04940/hsa:3002%09red/hsa:356%09red(Human immunodeficiency virus 1 infectionhsa05170CD247|FASLG|CD3E]http://www.genome.jp/kegg-bin/show_pathway?hsa05170/hsa:919%09red/hsa:916%09red/hsa:356%09red'Human T-cell leukemia virus 1 infectionhsa05166IL2RB|LCK|CD3E_http://www.genome.jp/kegg-bin/show_pathway?hsa05166/hsa:3560%09red/hsa:3932%09red/hsa:916%09redAutoimmune thyroid diseasehsa05320Phttp://www.genome.jp/kegg-bin/show_pathway?hsa05320/hsa:3002%09red/hsa:356%09redHematopoietic cell lineagehsa04640CD7|CD3EOhttp://www.genome.jp/kegg-bin/show_pathway?hsa04640/hsa:916%09red/hsa:924%09redPI3K-Akt signaling pathwayhsa04151IL2RB|FASLG|PPP2R2B_http://www.genome.jp/kegg-bin/show_pathway?hsa04151/hsa:3560%09red/hsa:5521%09red/hsa:356%09red=Viral protein interaction with cytokine and cytokine receptorhsa04061 IL2RB|CCL4Qhttp://www.genome.jp/kegg-bin/show_pathway?hsa04061/hsa:3560%09red/hsa:6351%09redSphingolipid signaling pathwayhsa04071 S1PR5|PPP2R2BRhttp://www.genome.jp/kegg-bin/show_pathway?hsa04071/hsa:5521%09red/hsa:53637%09redYersinia infectionhsa05135 ZAP70|LCKQhttp://www.genome.jp/kegg-bin/show_pathway?hsa05135/hsa:3932%09red/hsa:7535%09red Apoptosishsa04210Phttp://www.genome.jp/kegg-bin/show_pathway?hsa04210/hsa:3002%09red/hsa:356%09red Hepatitis Chsa05160 FASLG|PPP2R2BPhttp://www.genome.jp/kegg-bin/show_pathway?hsa05160/hsa:5521%09red/hsa:356%09red Necroptosishsa04217 STAT4|FASLGPhttp://www.genome.jp/kegg-bin/show_pathway?hsa04217/hsa:6775%09red/hsa:356%09red Hepatitis Bhsa05161Phttp://www.genome.jp/kegg-bin/show_pathway?hsa05161/hsa:6775%09red/hsa:356%09redPathways in cancerhsa05200IL2RB|STAT4|FASLG_http://www.genome.jp/kegg-bin/show_pathway?hsa05200/hsa:3560%09red/hsa:6775%09red/hsa:356%09red'Transcriptional misregulation in cancerhsa05202 IL2RB|GZMBQhttp://www.genome.jp/kegg-bin/show_pathway?hsa05202/hsa:3560%09red/hsa:3002%09redHuman cytomegalovirus infectionhsa05163 FASLG|CCL4Phttp://www.genome.jp/kegg-bin/show_pathway?hsa05163/hsa:6351%09red/hsa:356%09redRas signaling pathwayhsa04014 FASLG|ZAP70Phttp://www.genome.jp/kegg-bin/show_pathway?hsa04014/hsa:7535%09red/hsa:356%09redTerpenoid backbone biosynthesishsa00900MVDBhttp://www.genome.jp/kegg-bin/show_pathway?hsa00900/hsa:4597%09redMAPK signaling pathwayhsa04010 FASLG|DUSP2Phttp://www.genome.jp/kegg-bin/show_pathway?hsa04010/hsa:1844%09red/hsa:356%09redHuman papillomavirus infectionhsa05165Phttp://www.genome.jp/kegg-bin/show_pathway?hsa05165/hsa:5521%09red/hsa:356%09redAfrican trypanosomiasishsa05143FASLGAhttp://www.genome.jp/kegg-bin/show_pathway?hsa05143/hsa:356%09redNotch signaling pathwayhsa04330DTX3Dhttp://www.genome.jp/kegg-bin/show_pathway?hsa04330/hsa:196403%09redMalariahsa05144KLRK1Chttp://www.genome.jp/kegg-bin/show_pathway?hsa05144/hsa:22914%09redVEGF signaling pathwayhsa04370SH2D2ABhttp://www.genome.jp/kegg-bin/show_pathway?hsa04370/hsa:9047%09redCytosolic DNA-sensing pathwayhsa04623CCL4Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04623/hsa:6351%09redPlatinum drug resistancehsa01524Ahttp://www.genome.jp/kegg-bin/show_pathway?hsa01524/hsa:356%09red&Bacterial invasion of epithelial cellshsa05100SEPTIN1Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa05100/hsa:1731%09redInositol phosphate metabolismhsa00562PLCH2Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa00562/hsa:9651%09red!B cell receptor signaling pathwayhsa04662CARD11Chttp://www.genome.jp/kegg-bin/show_pathway?hsa04662/hsa:84433%09redSalmonella infectionhsa05132Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa05132/hsa:6351%09redmRNA surveillance pathwayhsa03015PPP2R2BBhttp://www.genome.jp/kegg-bin/show_pathway?hsa03015/hsa:5521%09redMorphine addictionhsa05032PDE4ABhttp://www.genome.jp/kegg-bin/show_pathway?hsa05032/hsa:5141%09red$Toll-like receptor signaling pathwayhsa04620Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04620/hsa:6351%09red3Parathyroid hormone synthesis, secretion and actionhsa04928Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04928/hsa:5141%09redNeurotrophin signaling pathwayhsa04722Ahttp://www.genome.jp/kegg-bin/show_pathway?hsa04722/hsa:356%09redAMPK signaling pathwayhsa04152Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04152/hsa:5521%09redOsteoclast differentiationhsa04380LCKBhttp://www.genome.jp/kegg-bin/show_pathway?hsa04380/hsa:3932%09redPurine metabolismhsa00230Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa00230/hsa:5141%09redDopaminergic synapsehsa04728Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04728/hsa:5521%09redFoxO signaling pathwayhsa04068Ahttp://www.genome.jp/kegg-bin/show_pathway?hsa04068/hsa:356%09redMetabolic pathwayshsa01100PLCH2|PDE4A|MVD`http://www.genome.jp/kegg-bin/show_pathway?hsa01100/hsa:9651%09red/hsa:5141%09red/hsa:4597%09red< Cell adhesion molecules (CAMs)hsa04514TIGITDhttp://www.genome.jp/kegg-bin/show_pathway?hsa04514/hsa:201633%09red)Non-alcoholic fatty liver disease (NAFLD)hsa04932Ahttp://www.genome.jp/kegg-bin/show_pathway?hsa04932/hsa:356%09red&Adrenergic signaling in cardiomyocyteshsa04261Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04261/hsa:5521%09redHippo signaling pathwayhsa04390Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04390/hsa:5521%09redWnt signaling pathwayhsa04310LGR6Chttp://www.genome.jp/kegg-bin/show_pathway?hsa04310/hsa:59352%09red Influenza Ahsa05164Ahttp://www.genome.jp/kegg-bin/show_pathway?hsa05164/hsa:356%09redTight junctionhsa04530Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04530/hsa:5521%09redChemokine signaling pathwayhsa04062Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04062/hsa:6351%09redProteoglycans in cancerhsa05205Ahttp://www.genome.jp/kegg-bin/show_pathway?hsa05205/hsa:356%09redRap1 signaling pathwayhsa04015SKAP1Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04015/hsa:8631%09redcAMP signaling pathwayhsa04024Bhttp://www.genome.jp/kegg-bin/show_pathway?hsa04024/hsa:5141%09red Endocytosishsa04144IL2RBBhttp://www.genome.jp/kegg-bin/show_pathway?hsa04144/hsa:3560%09red'Neuroactive ligand-receptor interactionhsa04080S1PR5Chttp://www.genome.jp/kegg-bin/show_pathway?hsa04080/hsa:53637%09red Herpes simplex virus 1 infectionhsa05168Ahttp://www.genome.jp/kegg-bin/show_pathway?hsa05168/hsa:356%09red--------------------protein kinase binding Gene Ontology GO:0019901SKAP1|CD3E|DUSP23http://amigo.geneontology.org/amigo/term/GO:0019901immune receptor activity GO:0140375 IL2RB|IL21R3http://amigo.geneontology.org/amigo/term/GO:0140375plasma membrane GO:0005886PDE4A|CD7|NCR3|ARL4C|LGR63http://amigo.geneontology.org/amigo/term/GO:0005886 cell junction GO:0030054TIGIT|SKAP1|NCR33http://amigo.geneontology.org/amigo/term/GO:0030054molecular adaptor activity GO:0060090 SKAP1|CD3E3http://amigo.geneontology.org/amigo/term/GO:0060090)transmembrane signaling receptor activity GO:0004888KLRK1|CD247|LGR63http://amigo.geneontology.org/amigo/term/GO:0004888membrane GO:0016020(PLEKHF1|SKAP1|S1PR5|PPP2R2B|MMP23B|PDE4A3http://amigo.geneontology.org/amigo/term/GO:0016020adenyl nucleotide binding GO:0030554RUNX3|ZAP70|PDE4A3http://amigo.geneontology.org/amigo/term/GO:0030554hydrolase activity GO:0016787PLCH2|FASLG|LCK|DUSP23http://amigo.geneontology.org/amigo/term/GO:0016787gene expression GO:0010467EOMES|TBX21|STAT4|PRF1|CD3E3http://amigo.geneontology.org/amigo/term/GO:0010467catalytic activity GO:0003824CARD11|MVD|MMP23B|CCL4|LCK3http://amigo.geneontology.org/amigo/term/GO:0003824phospholipid metabolic process GO:0006644 PLCH2|LCK3http://amigo.geneontology.org/amigo/term/GO:0006644regulation of cellular process GO:00507949LGR6|CLIC3|TBX21|EOMES|KLRK1|SH2D2A|PRF1|PDE4A|CD3E|DUSP23http://amigo.geneontology.org/amigo/term/GO:0050794glycoprotein metabolic process GO:0009100 MVD|SPOCK23http://amigo.geneontology.org/amigo/term/GO:0009100 signaling GO:00230525IL2RB|LGR6|PLEKHF1|CCL4|IL21R|PLCH2|SH2D2A|CD7|SPOCK23http://amigo.geneontology.org/amigo/term/GO:0023052=transcription regulatory region sequence-specific DNA binding GO:0000976 RUNX3|PRF13http://amigo.geneontology.org/amigo/term/GO:0000976 cell surface GO:0009986 KLRK1|IL2RB3http://amigo.geneontology.org/amigo/term/GO:0009986$trophectodermal cell differentiation GO:0001829EOMES3http://amigo.geneontology.org/amigo/term/GO:0001829$regulation of response to tumor cell GO:00028343http://amigo.geneontology.org/amigo/term/GO:0002834Lcysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:00971993http://amigo.geneontology.org/amigo/term/GO:0097199endodermal cell fate commitment GO:00017113http://amigo.geneontology.org/amigo/term/GO:00017113negative regulation of smoothened signaling pathway GO:0045879CD3E3http://amigo.geneontology.org/amigo/term/GO:0045879cpositive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:00028603http://amigo.geneontology.org/amigo/term/GO:0002860MHC protein binding GO:00422873http://amigo.geneontology.org/amigo/term/GO:0042287Hregulation of natural killer cell mediated immune response to tumor cell GO:00028553http://amigo.geneontology.org/amigo/term/GO:0002855cregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900739GZMB3http://amigo.geneontology.org/amigo/term/GO:1900739cellular anatomical entity GO:0110165(STAT4|GZMB|IL21R|MTFP1|FASLG|ARL4C|FCRL63http://amigo.geneontology.org/amigo/term/GO:0110165/positive regulation of neuron apoptotic process GO:00435253http://amigo.geneontology.org/amigo/term/GO:0043525:natural killer cell mediated immune response to tumor cell GO:00024233http://amigo.geneontology.org/amigo/term/GO:0002423phospholipase C activity GO:00046293http://amigo.geneontology.org/amigo/term/GO:0004629signaling adaptor activity GO:00355913http://amigo.geneontology.org/amigo/term/GO:0035591'positive regulation of cellular process GO:0048522CARD11|SH2D2A|SKAP1|LGR6|ZAP703http://amigo.geneontology.org/amigo/term/GO:00485226positive regulation of macromolecule metabolic process GO:0010604RUNX3|FASLG|CD3E3http://amigo.geneontology.org/amigo/term/GO:0010604 cell death GO:0008219KLRK1|IL2RB|FASLG|PPP2R2B3http://amigo.geneontology.org/amigo/term/GO:0008219;negative regulation of nucleic acid-templated transcription GO:1903507 RUNX3|FASLG3http://amigo.geneontology.org/amigo/term/GO:1903507extracellular matrix binding GO:0050840SPOCK23http://amigo.geneontology.org/amigo/term/GO:0050840:positive regulation of mitochondrial membrane permeability GO:00357943http://amigo.geneontology.org/amigo/term/GO:0035794Cregulation of tumor necrosis factor superfamily cytokine production GO:1903555SPON23http://amigo.geneontology.org/amigo/term/GO:1903555$response to external biotic stimulus GO:0043207TBX21|FASLG|CARD11|NCR3|KLRK13http://amigo.geneontology.org/amigo/term/GO:0043207 cytoplasm GO:0005737PLCH2|CARD11|LGR6|GZMB|PPP2R2B3http://amigo.geneontology.org/amigo/term/GO:0005737 regulation of cell-cell adhesion GO:0022407CARD11|CD247|LCK3http://amigo.geneontology.org/amigo/term/GO:0022407protein binding GO:0005515RUNX3|PPP2R2B|PDE4A|LGR6|GZMM3http://amigo.geneontology.org/amigo/term/GO:0005515mesoderm morphogenesis GO:00483323http://amigo.geneontology.org/amigo/term/GO:0048332response to chemokine GO:19908683http://amigo.geneontology.org/amigo/term/GO:19908683purine ribonucleoside diphosphate metabolic process GO:00091793http://amigo.geneontology.org/amigo/term/GO:0009179.regulation of protein localization to membrane GO:19054753http://amigo.geneontology.org/amigo/term/GO:1905475,ribonucleoside diphosphate metabolic process GO:00091853http://amigo.geneontology.org/amigo/term/GO:0009185heat shock protein binding GO:00310723http://amigo.geneontology.org/amigo/term/GO:0031072metal ion binding GO:0046872PDE4A|PRF1|SPON23http://amigo.geneontology.org/amigo/term/GO:0046872&protein localization to cell periphery GO:1990778PLEKHF13http://amigo.geneontology.org/amigo/term/GO:1990778$cullin-RING ubiquitin ligase complex GO:0031461FBXO443http://amigo.geneontology.org/amigo/term/GO:0031461signaling receptor binding GO:0005102 ZAP70|CCL43http://amigo.geneontology.org/amigo/term/GO:0005102Dregulation of establishment of protein localization to mitochondrion GO:19037473http://amigo.geneontology.org/amigo/term/GO:1903747"regulation of response to stimulus GO:0048583SH2D1B|FASLG|SKAP1|PLEKHF1|CD3E3http://amigo.geneontology.org/amigo/term/GO:0048583%integral component of plasma membrane GO:0005887 KLRK1|TIGIT3http://amigo.geneontology.org/amigo/term/GO:< 0005887protein phosphatase binding GO:00199033http://amigo.geneontology.org/amigo/term/GO:0019903leading edge membrane GO:00312563http://amigo.geneontology.org/amigo/term/GO:0031256&extrinsic component of plasma membrane GO:00198973http://amigo.geneontology.org/amigo/term/GO:0019897cytoplasmic side of membrane GO:0098562ZAP703http://amigo.geneontology.org/amigo/term/GO:0098562membrane-bounded organelle GO:0043227FASLG|STAT4|LGR6|PRF1|LCK3http://amigo.geneontology.org/amigo/term/GO:0043227"positive regulation of hemopoiesis GO:19037083http://amigo.geneontology.org/amigo/term/GO:1903708Kheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157NCR33http://amigo.geneontology.org/amigo/term/GO:0007157ribonucleotide binding GO:0032553 SEPTIN1|ZAP703http://amigo.geneontology.org/amigo/term/GO:0032553Wnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:19020423http://amigo.geneontology.org/amigo/term/GO:19020429positive regulation of endothelial cell apoptotic process GO:20003533http://amigo.geneontology.org/amigo/term/GO:2000353'inorganic anion transmembrane transport GO:0098661CLIC33http://amigo.geneontology.org/amigo/term/GO:00986610enzyme linked receptor protein signaling pathway GO:0007167 SH2D2A|FASLG3http://amigo.geneontology.org/amigo/term/GO:00071673positive regulation of leukocyte cell-cell adhesion GO:19030393http://amigo.geneontology.org/amigo/term/GO:1903039cellular process GO:0009987$SH2D1B|GZMM|PPP2R2B|MTFP1|ZAP70|PRF13http://amigo.geneontology.org/amigo/term/GO:00099879positive regulation of macromolecule biosynthetic process GO:0010557 TBX21|SKAP13http://amigo.geneontology.org/amigo/term/GO:0010557'regulation of primary metabolic process GO:0080090TBX21|RUNX3|PRF1|CD3E3http://amigo.geneontology.org/amigo/term/GO:0080090cell periphery GO:0071944PDE4A|SKAP1|NCR33http://amigo.geneontology.org/amigo/term/GO:0071944enzyme binding GO:00198993http://amigo.geneontology.org/amigo/term/GO:0019899ubiquitin ligase complex GO:00001513http://amigo.geneontology.org/amigo/term/GO:00001512negative regulation of apoptotic signaling pathway GO:20012343http://amigo.geneontology.org/amigo/term/GO:2001234\modification of morphology or physiology of other organism involved in symbiotic interaction GO:00518173http://amigo.geneontology.org/amigo/term/GO:0051817intrinsic component of membrane GO:0031224FASLG|LGR6|NCR33http://amigo.geneontology.org/amigo/term/GO:0031224organic cyclic compound binding GO:0097159SEPTIN1|ZAP70|LCK3http://amigo.geneontology.org/amigo/term/GO:0097159 GO:00072193http://amigo.geneontology.org/amigo/term/GO:0007219phosphatidylinositol binding GO:00350913http://amigo.geneontology.org/amigo/term/GO:0035091extrinsic component of membrane GO:00198983http://amigo.geneontology.org/amigo/term/GO:0019898Golgi subcompartment GO:00987913http://amigo.geneontology.org/amigo/term/GO:0098791voltage-gated channel activity GO:00228323http://amigo.geneontology.org/amigo/term/GO:0022832integral component of membrane GO:0016021IL2RB|MTFP1|CLIC33http://amigo.geneontology.org/amigo/term/GO:0016021binding GO:0005488TBX21|LGR6|MVD|DTX3|PPP2R2B3http://amigo.geneontology.org/amigo/term/GO:0005488,regulation of natural killer cell chemotaxis GO:20005013http://amigo.geneontology.org/amigo/term/GO:2000501primary metabolic process GO:0044238EOMES|GZMM|PLCH2|TBX21|DUSP23http://amigo.geneontology.org/amigo/term/GO:0044238endoderm formation GO:00017063http://amigo.geneontology.org/amigo/term/GO:0001706regulation of cell death GO:0010941IL2RB|FASLG|GZMB3http://amigo.geneontology.org/amigo/term/GO:0010941blastocyst formation GO:00018253http://amigo.geneontology.org/amigo/term/GO:0001825 membrane raft GO:00451213http://amigo.geneontology.org/amigo/term/GO:0045121membrane region GO:00985893http://amigo.geneontology.org/amigo/term/GO:0098589receptor complex GO:00432353http://amigo.geneontology.org/amigo/term/GO:0043235/cellular nitrogen compound biosynthetic process GO:0044271TBX21|PDE4A|STAT4|SKAP13http://amigo.geneontology.org/amigo/term/GO:0044271response to other organism GO:0051707TBX21|KLRK1|ZAP70|CCL43http://amigo.geneontology.org/amigo/term/GO:0051707peptide cross-linking GO:00181493http://amigo.geneontology.org/amigo/term/GO:0018149ion channel complex GO:00347023http://amigo.geneontology.org/amigo/term/GO:0034702cell leading edge GO:00312523http://amigo.geneontology.org/amigo/term/GO:0031252visual system development GO:01500633http://amigo.geneontology.org/amigo/term/GO:0150063 ion binding GO:00431673http://amigo.geneontology.org/amigo/term/GO:0043167peptidyl-serine modification GO:00182093http://amigo.geneontology.org/amigo/term/GO:00182092positive regulation of response to biotic stimulus GO:0002833 KLRK1|NCR33http://amigo.geneontology.org/amigo/term/GO:0002833,positive regulation of DNA metabolic process GO:0051054TBX213http://amigo.geneontology.org/amigo/term/GO:0051054CRNA polymerase II-specific DNA-binding transcription factor binding GO:00616293http://amigo.geneontology.org/amigo/term/GO:0061629phosphatase activity GO:0016791DUSP23http://amigo.geneontology.org/amigo/term/GO:0016791phospholipid binding GO:00055433http://amigo.geneontology.org/amigo/term/GO:0005543%intrinsic apoptotic signaling pathway GO:00971933http://amigo.geneontology.org/amigo/term/GO:0097193localization of cell GO:0051674TBX21|KLRK1|LGR63http://amigo.geneontology.org/amigo/term/GO:0051674extracellular organelle GO:0043230 FASLG|PRSS233http://amigo.geneontology.org/amigo/term/GO:0043230metabolic process GO:0008152 TBX21|CARD11|STAT4|SPOCK2|PRSS233http://amigo.geneontology.org/amigo/term/GO:0008152nucleoside binding GO:00018823http://amigo.geneontology.org/amigo/term/GO:0001882regulation of autophagy GO:00105063http://amigo.geneontology.org/amigo/term/GO:0010506%glycerophospholipid metabolic process GO:00066503http://amigo.geneontology.org/amigo/term/GO:0006650regulation of metabolic process GO:0019222KLRK1|PLEKHF1|PRF13http://amigo.geneontology.org/amigo/term/GO:0019222:positive regulation of nitrogen compound metabolic process GO:0051173 CARD11|FASLG3http://amigo.geneontology.org/amigo/term/GO:0051173protein N-linked glycosylation GO:00064873http://amigo.geneontology.org/amigo/term/GO:0006487$inositol phosphate metabolic process GO:00436473http://amigo.geneontology.org/amigo/term/GO:0043647regulation of lymphocyte anergy GO:00029113http://amigo.geneontology.org/amigo/term/GO:0002911Ras GTPase binding GO:00170163http://amigo.geneontology.org/amigo/term/GO:0017016response to organic substance GO:0010033TBX21|KLRK1|IL2RB|FASLG3http://amigo.geneontology.org/amigo/term/GO:0010033$epithelial to mesenchymal transition GO:00018373http://amigo.geneontology.org/amigo/term/GO:0001837&negative regulation of phosphorylation GO:00423263http://amigo.geneontology.org/amigo/term/GO:0042326)nucleoside phosphate biosynthetic process GO:19012933http://amigo.geneontology.org/amigo/term/GO:1901293dephosphorylation GO:00163113http://amigo.geneontology.org/amigo/term/GO:0016311plasma membrane protein complex GO:0098797CD2473http://amigo.geneontology.org/amigo/term/GO:0098797#phosphoric ester hydrolase activity GO:00425783http://amigo.geneontology.org/amigo/term/GO:0042578/RNA polymerase II regulatory region DNA binding GO:00010123http://amigo.geneontology.org/amigo/term/GO:0001012(regulation of T cell tolerance induction GO:00026643http://amigo.geneontology.org/amigo/term/GO:0002664perinuclear region of cytoplasm GO:00484713http://amigo.geneontology.org/amigo/term/GO:0048471vacuole GO:00057733http://amigo.geneontology.org/amigo/term/GO:0005773protein domain specific binding GO:00199043http://amigo.gen< eontology.org/amigo/term/GO:0019904(positive regulation of catabolic process GO:00098963http://amigo.geneontology.org/amigo/term/GO:0009896'regulation of protein metabolic process GO:0051246LCK|CCL43http://amigo.geneontology.org/amigo/term/GO:00512460positive regulation of protein metabolic process GO:0051247LCK|CD3E3http://amigo.geneontology.org/amigo/term/GO:0051247*nucleoside monophosphate metabolic process GO:00091233http://amigo.geneontology.org/amigo/term/GO:0009123&positive regulation of immune response GO:0050778TBX21|NCR3|ZAP70|CD3E3http://amigo.geneontology.org/amigo/term/GO:0050778immune system process GO:0002376EOMES|SH2D1B|CARD11|NCR3|SPON23http://amigo.geneontology.org/amigo/term/GO:0002376 organelle GO:0043226TBX21|RUNX3|SPON2|DUSP23http://amigo.geneontology.org/amigo/term/GO:0043226!intracellular signal transduction GO:0035556PLCH2|IL2RB|ZAP703http://amigo.geneontology.org/amigo/term/GO:0035556transferase complex GO:19902343http://amigo.geneontology.org/amigo/term/GO:19902345purine ribonucleoside monophosphate metabolic process GO:00091673http://amigo.geneontology.org/amigo/term/GO:0009167(positive regulation of metabolic process GO:0009893 KLRK1|PLEKHF13http://amigo.geneontology.org/amigo/term/GO:0009893mitochondrial envelope GO:00057403http://amigo.geneontology.org/amigo/term/GO:0005740!protein homodimerization activity GO:00428033http://amigo.geneontology.org/amigo/term/GO:0042803regulation of cell adhesion GO:0030155 SKAP1|SPOCK23http://amigo.geneontology.org/amigo/term/GO:0030155&regulatory region nucleic acid binding GO:0001067STAT43http://amigo.geneontology.org/amigo/term/GO:0001067+cellular macromolecule biosynthetic process GO:0034645TBX21|RUNX3|SKAP1|MVD3http://amigo.geneontology.org/amigo/term/GO:0034645regulation of proteolysis GO:00301623http://amigo.geneontology.org/amigo/term/GO:0030162viral gene expression GO:00190803http://amigo.geneontology.org/amigo/term/GO:0019080endopeptidase activity GO:0004175MMP23B3http://amigo.geneontology.org/amigo/term/GO:00041752chondroitin sulfate proteoglycan metabolic process GO:00506543http://amigo.geneontology.org/amigo/term/GO:00506542positive regulation of leukocyte mediated immunity GO:0002705 TBX21|NCR33http://amigo.geneontology.org/amigo/term/GO:0002705regulation of DNA recombination GO:00000183http://amigo.geneontology.org/amigo/term/GO:0000018%natural killer cell mediated immunity GO:0002228 NCR3|GZMB3http://amigo.geneontology.org/amigo/term/GO:0002228$regulation of multi-organism process GO:0043900 NCR3|CCL43http://amigo.geneontology.org/amigo/term/GO:0043900intracellular organelle lumen GO:00700133http://amigo.geneontology.org/amigo/term/GO:00700139negative regulation of cellular protein metabolic process GO:00322693http://amigo.geneontology.org/amigo/term/GO:0032269export from cell GO:01403523http://amigo.geneontology.org/amigo/term/GO:0140352GTPase activity GO:0003924ARL4C3http://amigo.geneontology.org/amigo/term/GO:0003924 regulation of biological process GO:0050789#KLRK1|S1PR5|RUNX3|CD247|ZAP70|PDE4A3http://amigo.geneontology.org/amigo/term/GO:0050789organelle envelope GO:00319673http://amigo.geneontology.org/amigo/term/GO:0031967pattern specification process GO:00073893http://amigo.geneontology.org/amigo/term/GO:0007389microtubule cytoskeleton GO:00156303http://amigo.geneontology.org/amigo/term/GO:0015630heterocycle metabolic process GO:0046483TBX21|RUNX3|FASLG|PDE4A3http://amigo.geneontology.org/amigo/term/GO:0046483"defense response to other organism GO:0098542SH2D1B|GZMM|LCK3http://amigo.geneontology.org/amigo/term/GO:0098542 peptidyl-amino acid modification GO:00181933http://amigo.geneontology.org/amigo/term/GO:0018193(intracellular membrane-bounded organelle GO:0043231TBX21|SKAP1|PRF13http://amigo.geneontology.org/amigo/term/GO:0043231regulation of catabolic process GO:00098943http://amigo.geneontology.org/amigo/term/GO:0009894 GO:00508523http://amigo.geneontology.org/amigo/term/GO:0050852protein phosphorylation GO:00064683http://amigo.geneontology.org/amigo/term/GO:0006468phosphorylation GO:0016310 RUNX3|ZAP703http://amigo.geneontology.org/amigo/term/GO:0016310regulation of isotype switching GO:00451913http://amigo.geneontology.org/amigo/term/GO:0045191%cellular protein modification process GO:0006464LCK|DTX33http://amigo.geneontology.org/amigo/term/GO:0006464Zactivation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:00972963http://amigo.geneontology.org/amigo/term/GO:0097296#organic substance metabolic process GO:0071704GZMM|IL2RB|MMP23B|PRF13http://amigo.geneontology.org/amigo/term/GO:0071704regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:00028223http://amigo.geneontology.org/amigo/term/GO:0002822(negative regulation of apoptotic process GO:00430663http://amigo.geneontology.org/amigo/term/GO:0043066macromolecule modification GO:0043412 SPOCK2|DUSP23http://amigo.geneontology.org/amigo/term/GO:0043412'purine ribonucleotide metabolic process GO:00091503http://amigo.geneontology.org/amigo/term/GO:0009150identical protein binding GO:00428023http://amigo.geneontology.org/amigo/term/GO:0042802-hydrolase activity, acting on acid anhydrides GO:00168173http://amigo.geneontology.org/amigo/term/GO:00168179negative regulation of transcription by RNA polymerase II GO:0000122RUNX33http://amigo.geneontology.org/amigo/term/GO:00001220regulation of defense response to virus by virus GO:00506903http://amigo.geneontology.org/amigo/term/GO:00506908positive regulation of intracellular signal transduction GO:1902533 CARD11|LCK3http://amigo.geneontology.org/amigo/term/GO:1902533)DNA-binding transcription factor activity GO:00037003http://amigo.geneontology.org/amigo/term/GO:0003700!nitric oxide biosynthetic process GO:00068093http://amigo.geneontology.org/amigo/term/GO:0006809biosynthetic process GO:0009058TBX21|RUNX3|CARD113http://amigo.geneontology.org/amigo/term/GO:0009058Rhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:00168183http://amigo.geneontology.org/amigo/term/GO:0016818'receptor signaling pathway via JAK-STAT GO:00072593http://amigo.geneontology.org/amigo/term/GO:0007259(cellular macromolecule metabolic process GO:0044260EOMES|CARD11|PRF1|SPOCK23http://amigo.geneontology.org/amigo/term/GO:0044260regulation of angiogenesis GO:00457653http://amigo.geneontology.org/amigo/term/GO:00457656phosphotransferase activity, alcohol group as acceptor GO:00167733http://amigo.geneontology.org/amigo/term/GO:0016773cellular biosynthetic process GO:0044249TBX21|KLRK1|MVD3http://amigo.geneontology.org/amigo/term/GO:0044249'negative regulation of cellular process GO:0048523 EOMES|FASLG3http://amigo.geneontology.org/amigo/term/GO:0048523,positive regulation of RNA metabolic process GO:00512543http://amigo.geneontology.org/amigo/term/GO:0051254/positive regulation of RNA biosynthetic process GO:19026803http://amigo.geneontology.org/amigo/term/GO:1902680intracellular organelle GO:0043229FASLG|PLEKHF1|PPP2R2B3http://amigo.geneontology.org/amigo/term/GO:00432295positive regulation of mononuclear cell proliferation GO:0032946 CARD11|CD3E3http://amigo.geneontology.org/amigo/term/GO:0032946#negative regulation of MAPK cascade GO:00434093http://amigo.geneontology.org/amigo/term/GO:0043409 regulation of catalytic activity GO:0050790 KLRK1|DUSP23http://amigo.geneontology.org/amigo/term/GO:0050790*positive regulation of cytokine production GO:00018193http://amigo.geneontology.org/amigo/term/GO:0001819*positive regulation of signal transduction GO:0009967CARD11|PLEKHF13http://amigo.geneontology.org/amigo/term/GO:0009967/regulation of < intracellular signal transduction GO:1902531 ZAP70|DUSP23http://amigo.geneontology.org/amigo/term/GO:1902531 viral process GO:00160323http://amigo.geneontology.org/amigo/term/GO:0016032bounding membrane of organelle GO:00985883http://amigo.geneontology.org/amigo/term/GO:0098588cellular chemical homeostasis GO:0055082 FASLG|LCK3http://amigo.geneontology.org/amigo/term/GO:0055082cellular protein localization GO:00346133http://amigo.geneontology.org/amigo/term/GO:0034613&intrinsic component of plasma membrane GO:00312263http://amigo.geneontology.org/amigo/term/GO:00312264positive regulation of cellular biosynthetic process GO:00313283http://amigo.geneontology.org/amigo/term/GO:0031328Gpositive regulation of nucleobase-containing compound metabolic process GO:00459353http://amigo.geneontology.org/amigo/term/GO:0045935apoptotic signaling pathway GO:00971903http://amigo.geneontology.org/amigo/term/GO:0097190purine ribonucleotide binding GO:00325553http://amigo.geneontology.org/amigo/term/GO:0032555phosphorus metabolic process GO:0006793 PDE4A|CARD113http://amigo.geneontology.org/amigo/term/GO:0006793lymphocyte differentiation GO:0030098 TBX21|CARD113http://amigo.geneontology.org/amigo/term/GO:0030098 ribonucleoside metabolic process GO:00091193http://amigo.geneontology.org/amigo/term/GO:0009119(positive regulation of apoptotic process GO:00430653http://amigo.geneontology.org/amigo/term/GO:0043065 drug binding GO:00081443http://amigo.geneontology.org/amigo/term/GO:0008144 cell adhesion GO:0007155 SPON2|ZAP703http://amigo.geneontology.org/amigo/term/GO:0007155molecular function regulator GO:00987723http://amigo.geneontology.org/amigo/term/GO:0098772tube development GO:00352953http://amigo.geneontology.org/amigo/term/GO:0035295immune effector process GO:0002252SH2D1B|SPON2|KLRK13http://amigo.geneontology.org/amigo/term/GO:0002252 cytoskeleton GO:00058563http://amigo.geneontology.org/amigo/term/GO:0005856$negative regulation of viral process GO:00485253http://amigo.geneontology.org/amigo/term/GO:0048525biological adhesion GO:00226103http://amigo.geneontology.org/amigo/term/GO:0022610 hemopoiesis GO:0030097 EOMES|ZAP703http://amigo.geneontology.org/amigo/term/GO:0030097 regulation of hydrolase activity GO:0051336 IL2RB|LCK3http://amigo.geneontology.org/amigo/term/GO:00513368positive regulation of alpha-beta T cell differentiation GO:00466383http://amigo.geneontology.org/amigo/term/GO:0046638(positive regulation of isotype switching GO:00458303http://amigo.geneontology.org/amigo/term/GO:00458300regulation of interleukin-2 biosynthetic process GO:00450763http://amigo.geneontology.org/amigo/term/GO:0045076!regulation of signal transduction GO:0009966 LCK|DUSP23http://amigo.geneontology.org/amigo/term/GO:0009966Bnegative regulation of cellular macromolecule biosynthetic process GO:2000113 EOMES|RUNX33http://amigo.geneontology.org/amigo/term/GO:2000113nucleus GO:0005634 TBX21|PRSS233http://amigo.geneontology.org/amigo/term/GO:0005634carbohydrate derivative binding GO:00973673http://amigo.geneontology.org/amigo/term/GO:0097367\somatic diversification of immune receptors via germline recombination within a single locus GO:00025623http://amigo.geneontology.org/amigo/term/GO:0002562regulation of defense response GO:0031347 SH2D1B|KLRK13http://amigo.geneontology.org/amigo/term/GO:0031347,negative regulation of RNA metabolic process GO:00512533http://amigo.geneontology.org/amigo/term/GO:0051253biological regulation GO:0065007SH2D1B|RUNX3|IL2RB|CD247|LCK3http://amigo.geneontology.org/amigo/term/GO:0065007&cellular response to organic substance GO:0071310 SPON2|CCL43http://amigo.geneontology.org/amigo/term/GO:0071310nucleotide binding GO:00001663http://amigo.geneontology.org/amigo/term/GO:0000166blood vessel development GO:00015683http://amigo.geneontology.org/amigo/term/GO:00015684positive regulation of response to external stimulus GO:0032103 CARD11|NCR33http://amigo.geneontology.org/amigo/term/GO:0032103cell population proliferation GO:0008283RUNX3|LCK|CD3E3http://amigo.geneontology.org/amigo/term/GO:0008283nucleoside phosphate binding GO:19012653http://amigo.geneontology.org/amigo/term/GO:1901265leukocyte aggregation GO:00704863http://amigo.geneontology.org/amigo/term/GO:0070486(negative regulation of metabolic process GO:0009892 EOMES|CD3E3http://amigo.geneontology.org/amigo/term/GO:00098920regulation of cellular protein metabolic process GO:00322683http://amigo.geneontology.org/amigo/term/GO:0032268 multicellular organismal process GO:0032501KLRK1|TIGIT|FASLG|CD3E|S1PR53http://amigo.geneontology.org/amigo/term/GO:0032501response to external stimulus GO:0009605TBX21|SPON2|ZAP703http://amigo.geneontology.org/amigo/term/GO:0009605macromolecule localization GO:00330363http://amigo.geneontology.org/amigo/term/GO:0033036extracellular exosome GO:00700623http://amigo.geneontology.org/amigo/term/GO:0070062regulation of GTPase activity GO:00430873http://amigo.geneontology.org/amigo/term/GO:0043087small molecule binding GO:00360943http://amigo.geneontology.org/amigo/term/GO:0036094$positive regulation of cell adhesion GO:00457853http://amigo.geneontology.org/amigo/term/GO:0045785!regulation of cytokine production GO:0001817 SPON2|CARD113http://amigo.geneontology.org/amigo/term/GO:0001817lymphocyte proliferation GO:00466513http://amigo.geneontology.org/amigo/term/GO:0046651T cell activation GO:00421103http://amigo.geneontology.org/amigo/term/GO:0042110 angiogenesis GO:00015253http://amigo.geneontology.org/amigo/term/GO:0001525*regulation of protein modification process GO:00313993http://amigo.geneontology.org/amigo/term/GO:0031399'catalytic activity, acting on a protein GO:01400963http://amigo.geneontology.org/amigo/term/GO:0140096nucleic acid binding GO:0003676PRF13http://amigo.geneontology.org/amigo/term/GO:0003676extracellular vesicle GO:19035613http://amigo.geneontology.org/amigo/term/GO:1903561Jpositive regulation of production of molecular mediator of immune response GO:00027023http://amigo.geneontology.org/amigo/term/GO:0002702+positive regulation of mast cell activation GO:00330053http://amigo.geneontology.org/amigo/term/GO:0033005#regulation of immune system process GO:0002682CARD11|TIGIT|ZAP703http://amigo.geneontology.org/amigo/term/GO:0002682"transcription by RNA polymerase II GO:00063663http://amigo.geneontology.org/amigo/term/GO:0006366Pregulation of cysteine-type endopeptidase activity involved in apoptotic process GO:00432813http://amigo.geneontology.org/amigo/term/GO:0043281organelle organization GO:0006996 SEPTIN1|FASLG3http://amigo.geneontology.org/amigo/term/GO:0006996>positive regulation of NF-kappaB transcription factor activity GO:00510923http://amigo.geneontology.org/amigo/term/GO:0051092 T cell differentiation in thymus GO:00330773http://amigo.geneontology.org/amigo/term/GO:0033077%regulation of immune effector process GO:0002697 TBX21|SH2D1B3http://amigo.geneontology.org/amigo/term/GO:0002697@positive regulation of natural killer cell mediated cytotoxicity GO:00459543http://amigo.geneontology.org/amigo/term/GO:0045954!regulation of platelet activation GO:00105433http://amigo.geneontology.org/amigo/term/GO:0010543peptidyl-tyrosine modification GO:00182123http://amigo.geneontology.org/amigo/term/GO:00182122regulation of nucleic acid-templated transcription GO:19035063http://amigo.geneontology.org/amigo/term/GO:1903506/regulation of T cell receptor signaling pathway GO:00508563http://amigo.geneontology.org/amigo/term/GO:0050856/regulation of peptidyl-tyrosine phosphorylation GO:00507303http://amigo.geneontology.org/amigo/term/GO:0050730'monovalent inorganic cation homeostasis GO:00550673http://amigo.geneontology.org/amigo/term/GO:0055067"regulation< of leukocyte activation GO:0002694 TBX21|CD3E3http://amigo.geneontology.org/amigo/term/GO:0002694,intracellular non-membrane-bounded organelle GO:00432323http://amigo.geneontology.org/amigo/term/GO:0043232response to biotic stimulus GO:0009607 SH2D1B|NCR33http://amigo.geneontology.org/amigo/term/GO:00096076positive regulation of leukocyte mediated cytotoxicity GO:00019123http://amigo.geneontology.org/amigo/term/GO:0001912 negative thymic T cell selection GO:00450603http://amigo.geneontology.org/amigo/term/GO:0045060!organophosphate metabolic process GO:00196373http://amigo.geneontology.org/amigo/term/GO:0019637#positive regulation of cell killing GO:00313433http://amigo.geneontology.org/amigo/term/GO:0031343%regulation of mast cell degranulation GO:00433043http://amigo.geneontology.org/amigo/term/GO:00433046positive regulation of alpha-beta T cell proliferation GO:00466413http://amigo.geneontology.org/amigo/term/GO:0046641symbiotic process GO:00444033http://amigo.geneontology.org/amigo/term/GO:0044403'cell surface receptor signaling pathway GO:0007166 CD7|LGR6|LCK3http://amigo.geneontology.org/amigo/term/GO:0007166 positive regulation of transport GO:0051050 ZAP70|GZMB3http://amigo.geneontology.org/amigo/term/GO:0051050&regulation of T cell mediated immunity GO:00027093http://amigo.geneontology.org/amigo/term/GO:0002709$skeletal muscle cell differentiation GO:00359143http://amigo.geneontology.org/amigo/term/GO:0035914*interspecies interaction between organisms GO:00444193http://amigo.geneontology.org/amigo/term/GO:0044419negative T cell selection GO:00433833http://amigo.geneontology.org/amigo/term/GO:0043383extracellular space GO:00056153http://amigo.geneontology.org/amigo/term/GO:0005615 nuclear lumen GO:00319813http://amigo.geneontology.org/amigo/term/GO:0031981$nucleic acid-templated transcription GO:00976593http://amigo.geneontology.org/amigo/term/GO:0097659regulation of kinase activity GO:00435493http://amigo.geneontology.org/amigo/term/GO:0043549interleukin-12 production GO:00326153http://amigo.geneontology.org/amigo/term/GO:0032615cellular response to stimulus GO:0051716PLCH2|CD7|DUSP23http://amigo.geneontology.org/amigo/term/GO:00517161positive regulation of cellular metabolic process GO:00313253http://amigo.geneontology.org/amigo/term/GO:0031325protein-containing complex GO:00329913http://amigo.geneontology.org/amigo/term/GO:0032991-organic hydroxy compound biosynthetic process GO:19016173http://amigo.geneontology.org/amigo/term/GO:19016171protein modification by small protein conjugation GO:00324463http://amigo.geneontology.org/amigo/term/GO:0032446alpha-beta T cell proliferation GO:00466333http://amigo.geneontology.org/amigo/term/GO:0046633leukocyte activation GO:0045321 CARD11|ZAP703http://amigo.geneontology.org/amigo/term/GO:0045321 tumor necrosis factor production GO:00326403http://amigo.geneontology.org/amigo/term/GO:0032640-regulation of macromolecule metabolic process GO:0060255PRF1|LCK3http://amigo.geneontology.org/amigo/term/GO:0060255#nitrogen compound metabolic process GO:0006807EOMES|KLRK1|MVD3http://amigo.geneontology.org/amigo/term/GO:0006807)regulation of response to biotic stimulus GO:00028313http://amigo.geneontology.org/amigo/term/GO:0002831#purine nucleotide metabolic process GO:00061633http://amigo.geneontology.org/amigo/term/GO:00061635regulation of immunoglobulin mediated immune response GO:00028893http://amigo.geneontology.org/amigo/term/GO:0002889.immune response-activating signal transduction GO:0002757 ZAP70|CD3E3http://amigo.geneontology.org/amigo/term/GO:00027573positive regulation of lymphocyte mediated immunity GO:00027083http://amigo.geneontology.org/amigo/term/GO:00027086nucleobase-containing small molecule metabolic process GO:00550863http://amigo.geneontology.org/amigo/term/GO:0055086#positive regulation of MAPK cascade GO:00434103http://amigo.geneontology.org/amigo/term/GO:0043410 MAPK cascade GO:00001653http://amigo.geneontology.org/amigo/term/GO:0000165#regulation of cellular localization GO:00603413http://amigo.geneontology.org/amigo/term/GO:0060341chromosome localization GO:00500003http://amigo.geneontology.org/amigo/term/GO:0050000response to nutrient levels GO:00316673http://amigo.geneontology.org/amigo/term/GO:0031667mast cell activation GO:00455763http://amigo.geneontology.org/amigo/term/GO:0045576.signal transduction by protein phosphorylation GO:00230143http://amigo.geneontology.org/amigo/term/GO:0023014leukocyte cell-cell adhesion GO:00071593http://amigo.geneontology.org/amigo/term/GO:0007159extracellular region GO:00055763http://amigo.geneontology.org/amigo/term/GO:0005576 cholesterol biosynthetic process GO:00066953http://amigo.geneontology.org/amigo/term/GO:0006695interleukin-6 production GO:00326353http://amigo.geneontology.org/amigo/term/GO:0032635"response to extracellular stimulus GO:00099913http://amigo.geneontology.org/amigo/term/GO:0009991%cellular response to interferon-gamma GO:00713463http://amigo.geneontology.org/amigo/term/GO:0071346$activation of innate immune response GO:00022183http://amigo.geneontology.org/amigo/term/GO:0002218isoprenoid metabolic process GO:00067203http://amigo.geneontology.org/amigo/term/GO:0006720leukocyte mediated cytotoxicity GO:00019093http://amigo.geneontology.org/amigo/term/GO:0001909(positive regulation of B cell activation GO:00508713http://amigo.geneontology.org/amigo/term/GO:0050871heterocyclic compound binding GO:19013633http://amigo.geneontology.org/amigo/term/GO:1901363-positive regulation of innate immune response GO:00450893http://amigo.geneontology.org/amigo/term/GO:0045089cellular metabolic process GO:0044237 PLEKHF1|DTX33http://amigo.geneontology.org/amigo/term/GO:0044237)positive regulation of hydrolase activity GO:00513453http://amigo.geneontology.org/amigo/term/GO:0051345alcohol metabolic process GO:00060663http://amigo.geneontology.org/amigo/term/GO:0006066sterol metabolic process GO:00161253http://amigo.geneontology.org/amigo/term/GO:0016125(regulation of lymphocyte differentiation GO:00456193http://amigo.geneontology.org/amigo/term/GO:0045619regulation of immune response GO:0050776 SH2D1B|SPON23http://amigo.geneontology.org/amigo/term/GO:0050776protein modification process GO:00362113http://amigo.geneontology.org/amigo/term/GO:0036211)regulation of leukocyte mediated immunity GO:0002703SH2D1B3http://amigo.geneontology.org/amigo/term/GO:0002703cellular homeostasis GO:00197253http://amigo.geneontology.org/amigo/term/GO:0019725+positive regulation of response to stimulus GO:0048584 CARD11|CD2473http://amigo.geneontology.org/amigo/term/GO:0048584'positive regulation of defense response GO:00313493http://amigo.geneontology.org/amigo/term/GO:00313490leukocyte activation involved in immune response GO:00023663http://amigo.geneontology.org/amigo/term/GO:0002366response to endogenous stimulus GO:00097193http://amigo.geneontology.org/amigo/term/GO:00097192regulation of multicellular organismal development GO:20000263http://amigo.geneontology.org/amigo/term/GO:2000026)negative regulation of catalytic activity GO:00430863http://amigo.geneontology.org/amigo/term/GO:0043086$regulation of innate immune response GO:00450883http://amigo.geneontology.org/amigo/term/GO:0045088?homophilic cell adhesion via plasma membrane adhesion molecules GO:00071563http://amigo.geneontology.org/amigo/term/GO:0007156'regulation of leukocyte differentiation GO:19021053http://amigo.geneontology.org/amigo/term/GO:1902105inflammatory response GO:00069543http://amigo.geneontology.org/amigo/term/GO:0006954drug metabolic process GO:00171443http://amigo.geneontology.org/amigo/term/GO:0017144)organonitrogen compound catabolic process GO:19015653http://amigo.geneontology.org/amigo/term/< GO:1901565response to stimulus GO:0050896SH2D1B|GZMM|CCL4|DTX33http://amigo.geneontology.org/amigo/term/GO:0050896$chemokine-mediated signaling pathway GO:00700983http://amigo.geneontology.org/amigo/term/GO:0070098 positive regulation of signaling GO:00230563http://amigo.geneontology.org/amigo/term/GO:0023056"cellular protein metabolic process GO:00442673http://amigo.geneontology.org/amigo/term/GO:0044267regulation of wound healing GO:00610413http://amigo.geneontology.org/amigo/term/GO:0061041+negative regulation of biosynthetic process GO:00098903http://amigo.geneontology.org/amigo/term/GO:0009890 intracellular GO:0005622 STAT4|PRSS233http://amigo.geneontology.org/amigo/term/GO:0005622)regulation of sequestering of calcium ion GO:00512823http://amigo.geneontology.org/amigo/term/GO:0051282&response to oxygen-containing compound GO:19017003http://amigo.geneontology.org/amigo/term/GO:1901700programmed cell death GO:00125013http://amigo.geneontology.org/amigo/term/GO:0012501"regulation of T cell proliferation GO:00421293http://amigo.geneontology.org/amigo/term/GO:0042129%peripheral nervous system development GO:00074223http://amigo.geneontology.org/amigo/term/GO:0007422response to chemical GO:0042221 KLRK1|PDE4A3http://amigo.geneontology.org/amigo/term/GO:0042221lipid biosynthetic process GO:00086103http://amigo.geneontology.org/amigo/term/GO:0008610protein metabolic process GO:00195383http://amigo.geneontology.org/amigo/term/GO:0019538"macromolecule biosynthetic process GO:0009059MVD|CD3E3http://amigo.geneontology.org/amigo/term/GO:0009059cofactor metabolic process GO:00511863http://amigo.geneontology.org/amigo/term/GO:0051186regulation of gene expression GO:00104683http://amigo.geneontology.org/amigo/term/GO:00104682positive regulation of cellular component movement GO:00512723http://amigo.geneontology.org/amigo/term/GO:0051272$cellular response to biotic stimulus GO:00712163http://amigo.geneontology.org/amigo/term/GO:0071216:positive regulation of cytosolic calcium ion concentration GO:00072043http://amigo.geneontology.org/amigo/term/GO:0007204circulatory system development GO:00723593http://amigo.geneontology.org/amigo/term/GO:0072359,cellular aromatic compound metabolic process GO:0006725 TBX21|STAT43http://amigo.geneontology.org/amigo/term/GO:0006725,positive regulation of immune system process GO:00026843http://amigo.geneontology.org/amigo/term/GO:0002684regulation of signaling GO:00230513http://amigo.geneontology.org/amigo/term/GO:0023051"regulation of leukocyte chemotaxis GO:00026883http://amigo.geneontology.org/amigo/term/GO:0002688myeloid leukocyte migration GO:00975293http://amigo.geneontology.org/amigo/term/GO:00975290nucleobase-containing compound metabolic process GO:0006139 FASLG|MVD3http://amigo.geneontology.org/amigo/term/GO:0006139regulation of cell motility GO:20001453http://amigo.geneontology.org/amigo/term/GO:2000145membrane organization GO:00610243http://amigo.geneontology.org/amigo/term/GO:0061024adaptive immune response GO:0002250 CD7|SKAP13http://amigo.geneontology.org/amigo/term/GO:0002250+antigen receptor-mediated signaling pathway GO:00508513http://amigo.geneontology.org/amigo/term/GO:0050851regulation of B cell activation GO:00508643http://amigo.geneontology.org/amigo/term/GO:0050864taxis GO:00423303http://amigo.geneontology.org/amigo/term/GO:0042330regulation of coagulation GO:00508183http://amigo.geneontology.org/amigo/term/GO:0050818)negative regulation of biological process GO:00485193http://amigo.geneontology.org/amigo/term/GO:0048519 chemotaxis GO:00069353http://amigo.geneontology.org/amigo/term/GO:0006935:negative regulation of nitrogen compound metabolic process GO:00511723http://amigo.geneontology.org/amigo/term/GO:0051172lymphocyte costimulation GO:00312943http://amigo.geneontology.org/amigo/term/GO:0031294T cell costimulation GO:00312953http://amigo.geneontology.org/amigo/term/GO:0031295response to cytokine GO:00340973http://amigo.geneontology.org/amigo/term/GO:0034097&cellular response to cytokine stimulus GO:0071345IL21R3http://amigo.geneontology.org/amigo/term/GO:0071345&negative regulation of gene expression GO:00106293http://amigo.geneontology.org/amigo/term/GO:0010629calcium-mediated signaling GO:00197223http://amigo.geneontology.org/amigo/term/GO:0019722 regulation of molecular function GO:00650093http://amigo.geneontology.org/amigo/term/GO:0065009(regulation of cellular metabolic process GO:00313233http://amigo.geneontology.org/amigo/term/GO:0031323immune system development GO:00025203http://amigo.geneontology.org/amigo/term/GO:00025201negative regulation of cellular metabolic process GO:00313243http://amigo.geneontology.org/amigo/term/GO:0031324$regulation of endopeptidase activity GO:00525483http://amigo.geneontology.org/amigo/term/GO:0052548stem cell differentiation GO:00488633http://amigo.geneontology.org/amigo/term/GO:0048863leukocyte chemotaxis GO:00305953http://amigo.geneontology.org/amigo/term/GO:0030595embryonic morphogenesis GO:00485983http://amigo.geneontology.org/amigo/term/GO:0048598cell migration GO:00164773http://amigo.geneontology.org/amigo/term/GO:0016477"regulation of cell differentiation GO:00455953http://amigo.geneontology.org/amigo/term/GO:0045595)movement of cell or subcellular component GO:00069283http://amigo.geneontology.org/amigo/term/GO:0006928immune response GO:0006955 EOMES|CD73http://amigo.geneontology.org/amigo/term/GO:0006955+positive regulation of leukocyte activation GO:00026963http://amigo.geneontology.org/amigo/term/GO:0002696&positive regulation of cell activation GO:00508673http://amigo.geneontology.org/amigo/term/GO:0050867regulation of T cell activation GO:00508633http://amigo.geneontology.org/amigo/term/GO:0050863)regulation of cellular component movement GO:00512703http://amigo.geneontology.org/amigo/term/GO:0051270 locomotion GO:00400113http://amigo.geneontology.org/amigo/term/GO:0040011cellular localization GO:00516413http://amigo.geneontology.org/amigo/term/GO:0051641"regulation of biosynthetic process GO:00098893http://amigo.geneontology.org/amigo/term/GO:0009889organic acid metabolic process GO:00060823http://amigo.geneontology.org/amigo/term/GO:00060826negative regulation of macromolecule metabolic process GO:00106053http://amigo.geneontology.org/amigo/term/GO:0010605#regulation of RNA metabolic process GO:00512523http://amigo.geneontology.org/amigo/term/GO:0051252!regulation of metal ion transport GO:00109593http://amigo.geneontology.org/amigo/term/GO:0010959 regulation of response to stress GO:00801343http://amigo.geneontology.org/amigo/term/GO:0080134*organic hydroxy compound metabolic process GO:19016153http://amigo.geneontology.org/amigo/term/GO:1901615#regulation of lymphocyte activation GO:00512493http://amigo.geneontology.org/amigo/term/GO:0051249response to bacterium GO:00096173http://amigo.geneontology.org/amigo/term/GO:0009617*regulation of transcription, DNA-templated GO:00063553http://amigo.geneontology.org/amigo/term/GO:0006355&regulation of RNA biosynthetic process GO:20011413http://amigo.geneontology.org/amigo/term/GO:2001141 small molecule metabolic process GO:00442813http://amigo.geneontology.org/amigo/term/GO:0044281#calcium ion transmembrane transport GO:00705883http://amigo.geneontology.org/amigo/term/GO:0070588multi-organism process GO:0051704TBX21|SEPTIN1|KLRK13http://amigo.geneontology.org/amigo/term/GO:0051704RNA biosynthetic process GO:00327743http://amigo.geneontology.org/amigo/term/GO:0032774tissue development GO:00098883http://amigo.geneontology.org/amigo/term/GO:0009888,organic cyclic compound biosynthetic process GO:19013623http://amigo.geneontology.org/amigo/term/GO:1901362axon development GO:00615643http://amigo.g<eneontology.org/amigo/term/GO:0061564cellular component organization GO:00160433http://amigo.geneontology.org/amigo/term/GO:0016043transcription, DNA-templated GO:00063513http://amigo.geneontology.org/amigo/term/GO:0006351signal transduction GO:0007165 KLRK1|GZMB3http://amigo.geneontology.org/amigo/term/GO:0007165Bimmune response-regulating cell surface receptor signaling pathway GO:00027683http://amigo.geneontology.org/amigo/term/GO:0002768&aromatic compound biosynthetic process GO:00194383http://amigo.geneontology.org/amigo/term/GO:0019438>regulation of nucleobase-containing compound metabolic process GO:00192193http://amigo.geneontology.org/amigo/term/GO:0019219,immune response-regulating signaling pathway GO:00027643http://amigo.geneontology.org/amigo/term/GO:0002764"central nervous system development GO:00074173http://amigo.geneontology.org/amigo/term/GO:00074173nucleobase-containing compound biosynthetic process GO:00346543http://amigo.geneontology.org/amigo/term/GO:0034654Bimmune response-activating cell surface receptor signaling pathway GO:00024293http://amigo.geneontology.org/amigo/term/GO:0002429nervous system development GO:0007399 RUNX3|SPOCK23http://amigo.geneontology.org/amigo/term/GO:0007399neuron projection morphogenesis GO:00488123http://amigo.geneontology.org/amigo/term/GO:0048812regulation of neurogenesis GO:00507673http://amigo.geneontology.org/amigo/term/GO:0050767inorganic anion transport GO:00156983http://amigo.geneontology.org/amigo/term/GO:0015698cell activation GO:0001775CD73http://amigo.geneontology.org/amigo/term/GO:00017751regulation of nitrogen compound metabolic process GO:00511713http://amigo.geneontology.org/amigo/term/GO:0051171regulation of exocytosis GO:00171573http://amigo.geneontology.org/amigo/term/GO:0017157)positive regulation of biological process GO:00485183http://amigo.geneontology.org/amigo/term/GO:0048518nervous system process GO:00508773http://amigo.geneontology.org/amigo/term/GO:0050877homeostatic process GO:00425923http://amigo.geneontology.org/amigo/term/GO:0042592neuron development GO:00486663http://amigo.geneontology.org/amigo/term/GO:0048666cell cycle process GO:00224023http://amigo.geneontology.org/amigo/term/GO:0022402cell differentiation GO:00301543http://amigo.geneontology.org/amigo/term/GO:0030154system development GO:0048731 ZAP70|SPOCK23http://amigo.geneontology.org/amigo/term/GO:0048731regulation of ion transport GO:00432693http://amigo.geneontology.org/amigo/term/GO:0043269vesicle-mediated transport GO:00161923http://amigo.geneontology.org/amigo/term/GO:0016192 anatomical structure development GO:00488563http://amigo.geneontology.org/amigo/term/GO:0048856lymphocyte mediated immunity GO:00024493http://amigo.geneontology.org/amigo/term/GO:0002449.regulation of multicellular organismal process GO:00512393http://amigo.geneontology.org/amigo/term/GO:0051239yadaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:00024603http://amigo.geneontology.org/amigo/term/GO:0002460,cellular nitrogen compound metabolic process GO:00346413http://amigo.geneontology.org/amigo/term/GO:0034641regulation of transport GO:00510493http://amigo.geneontology.org/amigo/term/GO:0051049nucleic acid metabolic process GO:00903043http://amigo.geneontology.org/amigo/term/GO:0090304macromolecule metabolic process GO:00431703http://amigo.geneontology.org/amigo/term/GO:0043170regulation of localization GO:00328793http://amigo.geneontology.org/amigo/term/GO:0032879response to stress GO:00069503http://amigo.geneontology.org/amigo/term/GO:0006950organelle fission GO:0048285 SEPTIN1|MTFP13http://amigo.geneontology.org/amigo/term/GO:0048285transmembrane transport GO:00550853http://amigo.geneontology.org/amigo/term/GO:0055085cell development GO:00484683http://amigo.geneontology.org/amigo/term/GO:0048468"multicellular organism development GO:00072753http://amigo.geneontology.org/amigo/term/GO:0007275 transport GO:00068103http://amigo.geneontology.org/amigo/term/GO:0006810establishment of localization GO:00512343http://amigo.geneontology.org/amigo/term/GO:0051234#multi-organism reproductive process GO:00447033http://amigo.geneontology.org/amigo/term/GO:0044703cell communication GO:00071543http://amigo.geneontology.org/amigo/term/GO:0007154 regulation of biological quality GO:00650083http://amigo.geneontology.org/amigo/term/GO:0065008 cell division GO:00513013http://amigo.geneontology.org/amigo/term/GO:0051301XSupplementary Table 4. 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