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Currency [0]/Explanatory TextG5Explanatory Text % 0Good;Good  a%1 Heading 1G Heading 1 ^^^%2 Heading 2G Heading 2 ^^^%?3 Heading 3G Heading 3 ^^^%23f4 Heading 49 Heading 4 ^^^% 5InputuInput ̙ ??v% 6 Linked CellK Linked Cell }% 7NeutralANeutral  W%"Normal 8Normal 2 9Normal 37Normal 3 % :Noteb Note   ;OutputwOutput  ???%????????? ???<$Percent =Title1Title ^^^% >TotalMTotal %? Warning Text? Warning Text %8???3ffff̙̙3f3fff3f3f33333f33333\`tESupplementary Table S44 9, Ethnicity 5Cataract (Bilateral)TChanges of skin, Intractable skin ulcers (Atrophic skin, tight skin, clavus, callus) Amputation 50Soft-tissue calcification (Achilles tendon, etc)Bird-like face4Abnormal voice (High pitched, squeaky, hoarse voice)(Abnormal glucose and/or lipid metabolism 5;Deformation and abnormality of the bone (Osteoporosis, etc)=Malignant tumors (Non-epithelial tumors, thyroid cancer, etc) 5Parental consanguinity 5BPremature atherosclerosis (Angina pectoris, myocardial infarction) Hypogonadism Short stature and low bodyweightJapanese 5+WS1WS2AgeMaleFemaleSexWRN gene mutation Achilles tendonAlopecia, 43yrBilateral, 25yrBilateral, 32yr4Ulcer, right second toe, 41yr, right first toe, 43yrNone&Insulin resistance, dyslipidemia, 43yr*Diabate (diet therapy), dyslipidemia, 48yr/Foot deformity (callus), bone density reduction(Foot deformity (flat foot), osteoporosis%Thyroid cancer, 48yr, meningioma 49yr9Severe right lower limb ischemia (endovascular treatment)Aortic valve stenosis, 48yr43yr Diagnosed, 43yr47yr Diagnosed, 47yr=Ulcer, right Achilles tendon, 40yr, left dorsum of foot, 47yrc.[3139-1G>C; 3139-1G>C]c.[3139-1G>C; 3913C>T]5Progeroid changes of hair (Gray hair, alopecia, etc.)Gray hair, alopecia, 41yr@Supplementary Table 4. 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