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L-Lactic acid
Riboflavin Sphingosine 1-phosphate Oxoglutaric acid D-Glutamine Cholic acid 7 L-Glutamic acid LysoPA(0:0/16:0)
CPA(18:1/0:0)# 1-heptadecanoyl-glycero-3-phosphate LysoPE(0:0/14:0) ADP LysoPE(0:0/15:0)& 1,25-Dihydroxyvitamin D3-26,23-lactone 13'-Carboxy-gamma-tocopherol Glycoursodeoxycholic acid LysoPE(0:0/16:1) Citramalic acid LysoPE(0:0/16:0) 3-Sulfodeoxycholic acid D-Xylose Glycocholic acid Cholesterol sulfate LysoPC(14:0/0:0) Xanthine LysoPE(0:0/18:1) L-Histidine LysoPC(15:0) Allantoin Adenosine triphosphate LysoPE(0:0/20:1) LysoPE(0:0/20:0) Taurocholic acid LysoPC(18:3) LysoPE(0:0/22:6) LysoPE(0:0/22:5) Alanyl-Alanine@ N-[(3a,5b,7b)-7-hydroxy-24-oxo-3-(sulfooxy)cholan-24-yl]-Glycine 5-Hydroxyvalproic acid 3-Hydroxymethylglutaric acid Hydrogen phosphate Cholesterol glucuronide Ceramide (d18:1/18:0) Uridine diphosphate glucose L-Phenylalanine
Biliverdin Arabinonic acid Cholic acid glucuronide 3-Phenoxypropionic acid Taurocholic acid 3-sulfate UDP-N-acetyl-D-mannosamine 2-Ketobutyric acid Homogentisic acid Oxidized glutathione) Cholestane-3,7,12,25-tetrol-3-glucuronide 2-Furoylglycine( Glycochenodeoxycholic acid 3-glucuronide Diethylthiophosphate Glycerol 3-phosphate PE(14:0/P-18:0)
PE(14:0/18:4)
PE(14:0/20:5)( 3-O-Sulfogalactosylceramide (d18:1/12:0) Quinaldic acid
PS(14:1/18:3)
PC(18:4/15:0) gamma-Aminobutyric acid Dehydroascorbic acid
PE(16:0/22:6) Suberic acid N-Acetylornithine
L-Arginine
PS(18:0/20:4) N-Acetyl-L-aspartic acid
Hippuric acid D-Glucose Ganglioside GD1a (d18:0/12:0) 3,4-Dihydroxyhydrocinnamic acid
Glycylleucine 3-Hydroxycapric acid 3-Hydroxybutyric acid Ethyl 4-(acetylthio)butyrate 5-Hydroxyindoleacetic acid Citric acid
Gluconic acid
Glyceric acid D-Erythrose 4-phosphate Sebacic acid Alanyl-Leucine L-Acetylcarnitine Valyl-Serine Indolelactic acid Dihydrolipoate
gamma-Asarone Traumatin Indoxyl sulfate. 5-Hexyltetrahydro-2-oxo-3-furancarboxylic acid Glutarate semialdehyde 12-Hydroxydodecanoic acid L-Valine Asparaginyl-Serine 5-Hydroxy-L-tryptophan L-Cystathionine Phenylalanyl-Glycine Methylmalonic acid - H y d r o x y i s o v a l e r i c a c i d Prolylhydroxyproline Traumatic acid
Myristic acid Erythrose Dodecanedioic acid Asparaginyl-Valine 4-Hydroxybenzaldehyde N'-Formylkynurenine L-Menthyl acetoacetate 3-Oxotetradecanoic acid Cytidine N-Undecanoylglycine Fucose 1-phosphate Uridine Leucyl-Leucine Aspartyl-Asparagine Alanyl-Tyrosine Histidinyl-Proline Daidzein Histidinyl-Valine Histidinyl-Threonine Dihydrothymine Tetradecanedioic acid Leucyl-Glutamine 5-Methylthioribose 1-phosphate gamma-Glutamylisoleucine L-beta-aspartyl-L-glutamic acid Phenylalanylproline Pyroglutamic acid Inosine Histidinyl-Hydroxyproline N-(p-Hydroxyphenethyl)actinidine Apigenin 3-Oxohexadecanoic acid Tridecanoylglycine 16-Hydroxy hexadecanoic acid Glutamyl-Gamma-glutamate Isoleucyl-Phenylalanine Glutaconic acid 12S-HHT
Linoleic acid Linoelaidic acid
Oleic acid Stearic acid Ketoleucine Hexadecanedioic acid Glutaminylphenylalanine gamma-Glutamylphenylalanine 9-HOTE 13-OxoODE 15(16)-EpODE N4-Acetylsulfamethoxazole 4-Hydroxyproline 9-HODE Ricinoleic acid
Leucinic acid N-Acetylgalactosamine 4-sulphate Ornithine Arachidonic acid dCMP Glutathione L-Aspartic acid dUMP N-Acetylneuraminic acid L-Malic acid 4'-Hydroxydiclofenac N-Undecylbenzenesulfonic acid 15,16-DiHODE Arachidic acid 2-Phenylacetamide 12,13-DHOME$ (9S,10S)-9,10-dihydroxyoctadecanoate N-Acetylarylamine 17,18-EpETE Pyruvic acid Hypoxanthine 4-Dodecylbenzenesulfonic Acid< Corchorifatty acid F Docosahexaenoic acid MG(0:0/16:0/0:0) Lysyl-Tryptophan Tryptophyl-Glutamate PGB2 12(R)-HPETE Prostaglandin B1 10,11-dihydro-leukotriene B4 Alpha-D-Glucose 1,6-bisphosphate# 2,3-Dinor-6-keto-prostaglandin F1 a
Inosinic acid O-Phosphoethanolamine Prostaglandin E2 Prostaglandin E1 Prostaglandin F1a 5-Hydroxyomeprazole Testosterone sulfate positive 7 5'-Methylthioadenosine 3-Dehydrosphinganine Sphinganine Uracil Decanoylcarnitine Asparaginyl-Tryptophan
Creatinine N,N-Dimethylsphingosine Palmitoyl Serinol 1-Isothiocyanatobutane Docosanamide L-Proline Guanidoacetic acid Indole Adenosine monophosphate Leu-Leu-Leu Benzeneacetonitrile MG(18:0/0:0/0:0) Cortisol Betaine 3, 5-Tetradecadiencarnitine trans-2-Tetradecenoylcarnitine Valine Sphinganine 1-phosphate
Vitamin D3 MG(0:0/20:0/0:0) L-Threonine 9,12-Hexadecadienoylcarnitine 4a-Methylzymosterol L-Palmitoylcarnitine 7-Ketocholesterol N,N-Dimethylaniline Linoleyl carnitine Oleoylcarnitine Tetracosanoylglycine Niacinamide 13'-Hydroxy-alpha-tocopherol Nicotinic acid Taurine Ethylphosphate LysoPE(22:6/0:0) Pipecolic acid Ceramide (d18:1/16:0) Cer(d18:0/18:0) 2,2-dichloro-1,1-ethanediol Creatine Bilirubin L-Isoleucine Tranylcypromine SM(d18:1/14:0) Glucosylceramide (d18:1/16:0)
PC(14:0/16:0) Adenine
PE(14:0/20:2)
PC(16:0/16:0)
PE(18:3/18:0)
PC(15:0/18:2)
Piperidine
PC(14:0/20:2)
PC(14:0/20:1)
PC(18:3/18:2) 2-Acetyl-3-methylpyrazine Betahistine
PC(18:1/18:1)
PS(18:1/18:1)
PC(20:3/18:1) 3-Hydroxybenzoic acid
Urocanic acid Galabiosylceramide (d18:1/16:0) TG(18:1/18:2/20:4) Proline betaine 3-Hexenedioic acid
Spermidine L-Lysine L-Methionine Methamphetamine Diethylphosphate L-Alanine
Pregabalin 2-Indolecarboxylic acid Aminoadipic acid L-Carnitine% 3-Methylsulfinylpropyl isothiocyanate 2-Hydroxycinnamic acid Uric acid 2,3-Diaminosalicylic acid
Levetiracetam
Metronidazole
Gabapentin
Glycylproline Indoleacetic acid Herniarin Allantoic acid 3-Succinoylpyridine Methyl n-formylanthranilate
L-Tyrosine 2-Hydroxyfluorene Trimethylamine N-oxide
Detomidine Indoleacrylic acid N8-Acetylspermidine N6,N6,N6-Trimethyl-L-lysine Methyl hippurate Caffeine' N-(4-hydroxyphenyl)ethoxycarbothioamide Cyclohexylamine
Thiabendazole Glutaral Spermine L-Tryptophan L-Kynurenine
Triethylamine
Sulfacetamide
Valyl-Proline Glycerylphosphorylethanolamine Valyl-Valine Propionylcarnitine Isoleucyl-Serine
Prilocaine Furazolidone Isoleucylproline
Ergothioneine
Leucyl-Valine Asparaginyl-Valine 7 Isobutyryl-L-carnitine Leucyl-Threonine+ 1-(2,4,5-Trimethoxyphenyl)-1,2-propanedione
Pirbuterol Leucyl-Isoleucine N1-Acetylspermine Alanyl-Arginine Prolyl-Methionine Aspartyl-Leucine Lysyl-Threonine Hexanoylcarnitine Adenosine Asparaginyl-Histidine Stearidonic acid Prolyl-Tyrosine Gamma-Linolenic acid Tyrosyl-Valine Oleamide N1,N12-Diacetylspermine Leucyl-Arginine Histamine Terbinafine Fold Change FDR HMDB0034491 Urolithin B 3-O-glucuronide 7 Perfluorooctanoic acid 7 # 1-heptadecanoyl-glycero-3-phosphate 7 HMDB0062318 7 MG(24:6/0:0/0:0) 7 PA(8:0/13:0) 7 HMDB0115484 7 Linoleamide 7 (R)-3-hydroxybutyrylcarnitine 7 O-Toluidine 7 Hexadecenal 7 HMDB0060482 7 Ethyl 4-ethoxybenzoate 7 HMDB0059898 7
Detomidine 7 HMDB0041872 7 , 1,2,3,4,Tetrahydro-1,5,7-trimethylnapthalene 7 HMDB0059696 7 N-Acetylthreonine 7 HMDB0062557 7 N-Methylethanolaminium phosphate 7 HMDB0060173 7 HMDB0062656 7 2-Hexylfuran 7 HMDB0039816 7 Thiomorpholine 3-carboxylate 7 HMDB0059611 7 Trans-urocanate 7 PC(18:318:2) 7 PC(o-16:0/20:4) 7 PE(O-18:1/20:4) 7 PC(P-16:0/P-18:1) 7 PE(18:1/P-18:1) 7 Palmitoyl sphingomyelin 7 Cer(d18:1/24:1) 7 DG(18:1/20:5/0:0) 7 1 3-carboxy-4-methyl-5-pentyl-2-furanpropanoic acid 7 1-Methyl-4-nitroimidazole 7 alpha-Methylstyrene 7 N-Acetylmuramoyl-Ala 7 Leu-Leu-Leu 7 & 2,3-Dihydroxy-2,4-cyclopentadien-1-one 7
Chlorobenzene 7 3-hydroxyoctanoyl carnitine 7 Leucyl-leucyl-norleucine 7 DG(8:0/0:0/8:0) 7 Methyl jasmonate 7 Uridine monophosphate (UMP) 7 12(S)-HETrE 7 $ (9S,10S)-9,10-dihydroxyoctadecanoate 7 Val-Val-Val 7 5-Hydroxyindole 7 5-O-Methylembelin 7 ) N5-Acetyl-N2-gamma-L-glutamyl-L-ornithine 7 N(2)-phenylacetyl-L-glutaminate 7 5-Sulfoxymethylfurfural 7 4-Vinylphenol sulfate 7 2,6-Dimethoxy-4-propylphenol 7 PI(16:0/18:1 7
PS(15:0/20:0) 7 PE(20:4/P-18:1) 7 Phenol sulphate 7 PE(18:3/P-18:1) 7 PE(16:1/P-18:0) 7 PE(16:1/P-18:1) 7 PE(18:4/P-16:0) 7 LysoPI(20:0/0:0) 7 DG(14:0/22:4)/0:0) 7 HMDB 7 HMDB0011590 7 HMDB0007031 7 HMDB0240260 7 HMDB0009213 7 HMDB0011405 7 HMDB0008983 7 HMDB0011411 7 HMDB0060015 7 HMDB0009414 7 HMDB0112327 7 HMDB0009782 7 HMDB0062181 7 HMDB0036226 7 HMDB0062775 7 HMDB0059752 7 HMDB0037326 7 HMDB0062645 7 HMDB0039423 7 HMDB0040867 7 HMDB0059805 7 HMDB0094676 7 HMDB0059633 7 HMDB0062747 7 HMDB0000288 7 HMDB0036583 7 HMDB0092900 7 - 7 HMDB0061634 7 HMDB0041855 7 HMDB0039437 7 HMDB0094648 7 HMDB0060494 7 HMDB0059899 7 HMDB0060659 7 HMDB0061643 7 HMDB0004953 7 HMDB0061712 7 HMDB0011235 7 HMDB0005779 7 HMDB0013407 7 HMDB0062562 7 HMDB0062735 7 HMDB0000005 7 HMDB0000034 7 HMDB0000036 7 HMDB0000043 7 HMDB0000045 7 HMDB0000050 7 HMDB0000054 7 HMDB0000062 7 HMDB0000063 7 HMDB0000064 7 HMDB0000070 7 HMDB0000079 7 HMDB0000089 7 HMDB0000094 7 HMDB0000098 7 HMDB0000099 7 HMDB0000112 7 HMDB0000114 7 HMDB0000122 7 HMDB0000125 7 HMDB0000126 < 7 HMDB0000128 7 HMDB0000130 7 HMDB0000138 7 HMDB0000139 7 HMDB0000148 7 HMDB0000156 7 HMDB0000157 7 HMDB0000158 7 HMDB0000159 7 HMDB0000161 7 HMDB0000162 7 HMDB0000167 7 HMDB0000172 7 HMDB0000175 7 HMDB0000177 7 HMDB0000182 7 HMDB0000190 7 HMDB0000191 7 HMDB0000195 7 HMDB0000197 7 HMDB0000201 7 HMDB0000202 7 HMDB0000207 7 HMDB0000208 7 HMDB0000214 7 HMDB0000222 7 HMDB0000224 7 HMDB0000230 7 HMDB0000243 7 HMDB0000244 7 HMDB0000251 7 HMDB0000267 7 HMDB0000269 7 HMDB0000277 7 HMDB0000286 7 HMDB0000289 7 HMDB0000292 7 HMDB0000296 7 HMDB0000300 7 HMDB0000301 7 HMDB0000355 7 HMDB0000357 7 HMDB0000393 7 HMDB0000423 7 HMDB0000426 7 HMDB0000439 7 HMDB0000462 7 HMDB0000472 7 HMDB0000501 7 HMDB0000510 7 HMDB0000517 7 HMDB0000538 7 HMDB0000539 7 HMDB0000562 7 HMDB0000564 7 HMDB0000583 7 HMDB0000593 7 HMDB0000594 7 HMDB0000619 7 HMDB0000620 7 HMDB0000623 7 HMDB0000625 7 HMDB0000626 7 HMDB0000651 7 HMDB0000653 7 HMDB0000665 7 HMDB0000671 7 HMDB0000672 7 HMDB0000673 7 HMDB0000682 7 HMDB0000684 7 HMDB0000695 7 HMDB0000696 7 HMDB0000705 7 HMDB0000708 7 HMDB0000714 7 HMDB0000721 7 HMDB0000725 7 HMDB0000734 7 HMDB0000736 7 HMDB0000738 7 HMDB0000754 7 HMDB0000759 7 HMDB0000763 7 HMDB0000781 7 HMDB0000792 7 HMDB0000806 7 HMDB0000812 7 HMDB0000824 7 HMDB0000827 7 HMDB0000842 7 HMDB0000859 7 HMDB0000870 7 HMDB0000872 7 HMDB0000876 7 HMDB0000883 7 HMDB0000893 7 HMDB0000925 7 HMDB0000929 7 HMDB0000933 7 HMDB0000963 7 HMDB0000969 7 HMDB0000973 7 HMDB0000992 7 HMDB0001008 7 HMDB0001020 7 HMDB0001043 7 HMDB0001173 7 HMDB0001186 7 HMDB0001200 7 HMDB0001202 7 HMDB0001209 7 HMDB0001217 7 HMDB0001220 7 HMDB0001250 7 HMDB0001256 7 HMDB0001257 7 HMDB0001264 7 HMDB0001265 7 HMDB0001321 7 HMDB0001325 7 HMDB0001341 7 HMDB0001383 7 HMDB0001406 7 HMDB0001409 7 HMDB0001442 7 HMDB0001460 7 HMDB0001480 7 HMDB0001488 7 HMDB0001847 7 HMDB0002059 7 HMDB0002117 7 HMDB0002124 7 HMDB0002172 7 HMDB0002183 7 HMDB0002189 7 HMDB0002203 7 HMDB0002212 7 HMDB0002229 7 HMDB0002277 7 HMDB0002285 7 HMDB0002409 7 HMDB0002466 7 HMDB0002504 7 HMDB0002577 7 HMDB0002579 7 HMDB0002581 7 HMDB0002641 7 HMDB0002649 7 HMDB0002685 7 HMDB0002833 7 HMDB0002982 7 HMDB0003045 7 HMDB0003073 7 HMDB0003312 7 HMDB0003337 7 HMDB0003357 7 HMDB0003423 7 HMDB0003514 7 HMDB0004236 7 HMDB0004668 7 HMDB0004692 7 HMDB0004705 7 HMDB0004827 7 HMDB0004833 7 HMDB0004949 7 HMDB0004950 7 HMDB0004971 7 HMDB0005015 7 HMDB0005065 7 HMDB0005462 7 HMDB0005780 7 HMDB0006095 7 HMDB0006270 7 HMDB0006294 7 HMDB0006469 7 HMDB0006547 7 HMDB0006695 7 HMDB0007005 7 HMDB0007849 7 HMDB0007869 7 HMDB0007879 7 HMDB0007880 7 HMDB0007940 7 HMDB0008171 7 HMDB0008231 7 HMDB0008367 7 HMDB0008832 7 HMDB0008835 7 HMDB0008840 7 HMDB0008851 7 HMDB0009123 7 HMDB0010165 7 HMDB0010206 7 HMDB0010208 7 HMDB0010212 7 HMDB0010223 7 HMDB0010224 7 HMDB0010330 7 HMDB0010355 7 HMDB0010379 7 HMDB0010381 7 HMDB0010387 7 HMDB0010715 7 HMDB0010730 7 HMDB0010733 7 HMDB0011131 7 HMDB0011164 7 HMDB0011170 7 HMDB0011174 7 HMDB0011177 7 HMDB0011470 7 HMDB0011472 7 HMDB0011473 7 HMDB0011474 7 HMDB0011475 7 HMDB0011481 7 HMDB0011482 7 HMDB0011494 7 HMDB0011496 7 HMDB0011526 7 HMDB0011533 7 HMDB0011542 7 HMDB0011718 7 HMDB0011761 7 HMDB0011777 7 HMDB0012097 7 HMDB0012209 7 HMDB0012210 7 HMDB0012228 7 HMDB0012233 7 HMDB0012311 7 HMDB0012348 7 HMDB0012390 7 HMDB0012504 7 HMDB0012535 7 HMDB0012557 7 HMDB0012559 7 HMDB0013112 7 HMDB0013159 7 HMDB0013163 7 HMDB0013286< 7 HMDB0013310 7 HMDB0013317 7 HMDB0013329 7 HMDB0013331 7 HMDB0013334 7 HMDB0013645 7 HMDB0013654 7 HMDB0013854 7 HMDB0013898 7 HMDB0013974 7 HMDB0014010 7 HMDB0014375 7 HMDB0014752 7 HMDB0014772 7 HMDB0014868 7 HMDB0014888 7 HMDB0014890 7 HMDB0014995 7 HMDB0015052 7 HMDB0015333 7 HMDB0015407 7 HMDB0015517 7 HMDB0015644 7 HMDB0028680 7 HMDB0028681 7 HMDB0028691 7 HMDB0028699 7 HMDB0028733 7 HMDB0028740 7 HMDB0028742 7 HMDB0028744 7 HMDB0028748 7 HMDB0028757 7 HMDB0028804 7 HMDB0028833 7 HMDB0028886 7 HMDB0028893 7 HMDB0028895 7 HMDB0028898 7 HMDB0028914 7 HMDB0028916 7 HMDB0028923 7 HMDB0028927 7 HMDB0028932 7 HMDB0028933 7 HMDB0028939 7 HMDB0028942 7 HMDB0028961 7 HMDB0028962 7 HMDB0028995 7 HMDB0029023 7 HMDB0029029 7 HMDB0029082 7 HMDB0029118 7 HMDB0029135 7 HMDB0029136 7 HMDB0029140 7 HMDB0029599 7 HMDB0029758 7 HMDB0029872 7 HMDB0030001 7 HMDB0030347 7 HMDB0030984 7 HMDB0031033 7 HMDB0031328 7 HMDB0031404 7 HMDB0031771 7 HMDB0032259 7 HMDB0032369 7 HMDB0032398 7 HMDB0032539 7 HMDB0032549 7 HMDB0033179 7 HMDB0034171 7 HMDB0034297 7 HMDB0034301 7 HMDB0035919 7 HMDB0059587 7 HMDB41787 7 METPA1168 7 HMDB0041965 N-Lactoylvaline 7 HMDB0007201 7 HMDB0009049 7 (±)-Camphoric acid 7 Deoxycholic acid 7 VIP 7 T.stat 7 T.test.p.value 7 ID 7 FC 7 PValue Classification ABAT Neurotransmitter ADCY1
Signalling ADCY2 ADCY5 ADH1A Multipurpose ADH1B ADH4 ADH6 ADH7 ALDH1A1 ALDOB
Glycolysis ALOX15 Hormone AMY1A Sugar AMY2B AOAH Other AQP8 Small Molecule Transport AQP3 AQP4 ARG1 Urea ARG2 ATP1A3
Ion Transport ATP1B2 ATP2A3 ATP2B2 ATP4A HCN2 CA1 CACNA1A CACNA1B CACNA1D CACNB2 CACNG1 CES1 Detox CHI3L2
Aminosugar CHRNB2 CHRNG CYP1A2 Steroid CYP2E1 CYP3A4 CYP4A11
Fatty Acid DGKQ Membrane Lipid DDC DIO3 SLC26A3 FMO2 FOLR1 G6PC Carbohydrate Storage GABRA1 GABRA3 GABRB1 GABRB2 GABRB3 GABRR1 GATM GCH1 BH4 GCK GCNT1 Glycan GLRA1 GLS Glutamate GPD1 GPLD1
Glycan Anchor GPX3 GRIA2 GRIA3 GRIA4 GRIK2 GRIK4 GRIK5 GRIN2B GSTA2 GUCY2C HDC Histidine HPD Tyrosine HTR3A KCNA1 KCNA3 KCNA5 KCNA6 KCNB1 KCNC1 KCNC2 KCNG1 KCNH2 KCNJ2 KCNJ3 KCNJ6 KCNJ10 KCNJ11 KCNMB1 KCNN2 KCNQ3 LCT LPO Redox CYP4F3 MTTP NOS1 Reactive Oxygen NOS2 P2RX1 PDE3B PDE6G ENPP2
Nucleotide PGM5 PTGIS QDPR SCNN1B SI ST8SIA1 SLC2A1 SLC2A2 SLC2A4 SLC6A4 SLC6A13 SLC7A2 SLC8A2 SLC8A3 SLC10A2 SLC12A3 SLC18A1 SLC18A2 SLC22A4 ELOVL4 SULT1A2 Sulfate SULT2A1 ABCC8 ABC Transporter TAT TPO TYR Pigment UGT2B10 UGT2B15 SLC30A2 BSND SLC7A5 TKTL1 Pentose Phosphate PDE8B FBP2 CACNA1I MGAM P2RX6 LRAT Vitamin A CACNA2D2 KCNB2 KL SLC4A8 PTGES CLCA2 PLCH2 HS3ST4 Heparin Sulfate HS3ST3B1 HCN4 DHRS2 KCNMB2 ABCA9 CACNG2 ATP8A1 PEMT LASS1 Sphingolipid FTCD CYP46A1 SLC26A1 SDS
Amino Acid CLCA4 NMNAT2 NAD ACSL6 KCNH3 SLC7A8 ABCA6 PIK3R5 Inositol Phosphate CHST5 Glycan Sulfate PLD3 MGAT4C PLA2G2D AK5 Purine GNMT DHDH ST8SIA5 GALNT9 SLC45A2 SLC22A17 NAT8B UPB1
Pyrimidine ATP8A2 HAO1
Glyoxylate PIGG CYP2W1 SLC38A4 MCOLN3 ACOXL SVOP OGDHL Krebs CACNA2D3 ADCY10 SLC7A10 CA10 TRPC7 SLC4A10 SLC12A5 HCN3 SLC7A14 PRODH2 Proline ACE2 CACNG7 ABCG5 NDST4 NOX5 TRPM3 ASRGL1 KCNH6 ACSBG2
ST6GALNAC5 CHST9 KCNK16 MFSD7 Other Transport SLC22A16 HS6ST2 GLYATL1 GALNT13 COX6B2
Complex IV ACMSD
Tryptophan MDH1B ENPP6 SLC34A3 LIPJ GLT1D1 RDH12 ABHD12B MGAT5B SLC35F3 SLC5A8 SLC30A8 IDO2 SLC29A4 MCOLN2 HS6ST3 SLC39A5 SLC26A11 SLC9A9 ENPP7 NAT8L SLC35F4 PLCXD3 B3GNT8 KCTD4 SLC16A12 SLC6A17 MCART6 GALNTL6 AQP12B PCDHA5 CDH4 SERPIND1 BTBD11 GPR179 TMEM132B FGB PTPRT FSTL4 MYO18B WDR16 CCKAR VSTM2A CDH12 FLJ26850 FLJ43860 EMID2 GAGE2D SYT5 IL4 C20orf26 LOC255167 SPOCK3 GAGE1 RIMS4 PAPPA2 UBE2QL1 TTLL9 MOBKL1A PAGE2B NAA20 SPEF1 RFPL1 GNAS CDHR3 SH3GL3 LOC400891 SSTR2 LRP11 EYA1 TUBB1 GPR142 TMEM132E LRRC4B KLRC2 PRB2 DDN SEZ6L RIMBP2 SNTG1 GAGE4 SERPINA10 GPR113 ck0010 LRP1B LOC644165 LGI3 C14orf101 C1orf158 DNAI2 ABHD15 PPP4R4 F10 CCDC65 CNIH2 POPDC3 GRM1 GPR149 PRB1 FAM167A FAM5B PHF21B AGT CSMD1 BTBD17 KLRG2 WNT4 LRRC10B COL25A1 EDN3 ASXL3 LOC153328 ZDHHC22 USH2A EML5 PCSK2 COL2A1 MTMR7 C6orf118 ST18 PCDHA8 RSPH10B2 HAP1 LOC150527 TRIM67 ELAVL3 QPCT MAFB ANKRD26P1 CAPN14 ck0038 MAGEA1 CLGN TRIM9 CPLX1 TTC8 ZNF705A RGS9 SERPINA11 C6orf103 CPE ISL1 IRX2 TMEM63C LY6H RNF17 DCC C8orf45 ISM2 VGF C17orf72 FGA CELF5 KIAA1958 LRRC67 MGC16703 GC TMEM59L MYO16 CCNA1 GPR119 PPIL6 EFNB3 FAM179A C6orf27 SPANXC ANKS1B LPPR1 UNC13A FAM135B SPATS1 INSL5 C5orf27 C12orf76 LRP2BP PCGF3 C14orf148 OSBP2 GPR148 RASD1 DIRAS2 FAM23A PPP1R1A SGK3 C9orf24 DLK2 IQSEC3 GPER SPANXB2 SNORD115-26 EPHA5 CHGB CASKIN1 TMEM86B RIMS2 C22orf42 SSTR3 MYT1 CCDC151 GPRIN1 DPP6 SHISA7 ATG9B PARM1 SLC22A10 FAM163A TMED8 CEACAM19 C1orf194 ARX SPATA4 LOXL4 GPR64 APLP1 KBTBD10 KIF3A ZNF34 MAGI2 CDH26 CD99L2 BAIAP3 PART1 CHRM4 MSI1 ABCA11P PTPRN TMEM145 KCNIP1 SMCR7 SHANK1 ASTN1 PCDHA2 TP53I13 LOC729467 C9orf171 PNMA2 ARHGAP39 RTN1 DUSP15 TTR SYT4 CALY MAMLD1 C19orf63 C4orf44 C13orf36 NECAB2 DPY19L2P1 PAGE5 CCDC11 C20orf46 DPY19L2P2 PELI3 LDLRAD1 C1orf141 HAR1A MAST1 PTPRN2 GAK USH1G C10orf10 PRLR C10orf79 DNAH9 C9orf117 SYT3 C10orf93 P4HTM C1orf168 FAM154B ARVCF VCX3A RXFP3 REM2 C20orf12 EFR3B TCTN1 RTL1 FAM123A DLGAP3 ZNF483 C3orf67 LRTM2 SERPINF2 FBXL21 CDKL2 ck0004 KIAA1244 USP27X INSM1 GNAZ PHLDB3 SPTBN4 KIAA1377 PCDHGA3 CCDC40 DPP4 WDR63 FOXD4L2 ODZ1 EFCAB10 CRH KGFLP2 TMEM132D DIRAS1 TPPP GAGE2A C6orf154 ASB16 CXXC4< LOC728392 TMEM130 LOC100272217 LRRC4 C20orf132 CASP14 DLGAP2 ROPN1L AMPH FAM171A2 SYT14 CCDC108 LRRC37A3 RFX6 NAPB CDK5R2 C8orf42 SGSM1 CRHBP LRRC16B GPR6 C5orf49 OR2L13 NOL4 TUSC3 JAKMIP2 C21orf29 SCG5 TEKT2 DSCAM PPM1E CRYBA2 RAP1GAP2 GIPR PPP2R2B LETM2 KRT81 ADAMTS18 SPTB XKR7 PAX6 TMEM90B FST GPR162 TEKT1 DUSP26 ALX1 WFS1 GLIPR1L2 C22orf45 ck0016 COL6A6 RUNDC3A KIF5A NKX2-2 C2orf50 CDH8 RIBC1 PDZD2 C12orf68 CRHR2 CCDC96 CDH18 MAPK8IP2 RNF222 FAM81B SNPH C5orf38 TMEM232 C7orf52 RPRM C11orf16 RAB36 DPY19L2P4 RSPH4A TMEM179 ARMC3 TCAP NCAM1 LMO1 CRMP1 C2orf39 KIAA1045 CHGA GPR153 REEP2 JPH3 ANGPTL3 RFPL2 OXGR1 RASGRF1 ck0055 WDR66 RFX2 DNER RHOXF1 RNF182 BCAM C12orf34 DNAI1 CPLX2 MAPT LRRTM2 GAGE12D CELF4 FKBP2 C6orf26 PACRG STC2 LAMA5 RASA4 TEKT4 OR13A1 GPR19 KRT78 CHRDL2 SLAMF9 ERO1LB AVPR1B GPR20 SRCIN1 LOC100130872 FBXO15 EFCAB6 C9orf4 BSN NBEA S100Z TTC25 C14orf174 PDZD4 ADAM11 LRRC24 CCDC87 EML6 SEZ6L2 ANKRD7 KLKB1 PRLHR GZMH NXF2B MCF2L2 RSPH9 KLHL3 BPIL1 LRRC46 CXCR6 TTC29 GATSL1 GNAI1 NDRG4 FGF17 KSR2 RTBDN LRRC23 C20orf152 MAPK12 FBLL1 TTC18 RBP2 PPFIA3 CFC1B POU4F1 DOCK3 ZNF185 FAM183A SERPINI1 PCDHA6 TMEM151A ADAM29 GPR171 LOC389332 CLSTN2 KIAA1409 NTNG1 VWA5B2 SPRR2A IGFBPL1 LMX1B OSBPL6 PCDHA1 SYP DENND2A GPR150 C2CD4A KNDC1 EPOR GPR135 CXorf57 MAP3K15 SPC25 NKAIN1 PRRT3 SDK2 WSCD1 RAB3A SPANXE C21orf58 C7orf51 C1orf230 PYHIN1 CCDC158 FBXO16 C11orf41 LOC100130386 ZFR2 POU6F2 SCGB1A1 IL18RAP FOXD4L5 WDR17 SMOC1 CELSR3 PLK2 SNAP91 F7 INA SERPINA1 LYPD3 PCDHB4 DYNC1I1 XPNPEP2 PCLO GNG4 KLRB1 CELF3 TTC24 NXF2 RGL4 C20orf201 LOC401127 KLRC3 CD8A GZMB SERPINA12 MAK TSPAN19 PACSIN1 MPP2 PNMAL1 REC8 LOC285419 PPP1R3F CD2 DAB1 DCAF12L2 DNAJC6 EGR4 RPH3AL CCDC13 SSTR5 ITGA2B SPINK7 PODXL2 DARC LYVE1 HMP19 DSCAML1 TRIM46 WDR65 PCP4 C15orf26 C14orf132 CAMK2B JAKMIP3 CCDC74B DDX53 THEMIS TMEM190 CD96 RTN4RL1 CNIH3 MRGPRX3 PCSK1N KIAA1324 CNTN5 SCG3 SOX15 HPR MED12L CLEC4E APOA4 FAM123C TLL1 CAPSL MAP7D2 C9orf172 TMIE SNAP25 LOC401431 LY9 CMA1 NOVA1 FAM65B SCRT1 SEZ6 FAM92B RGS7 FAM184B FLJ37201 GPR98 MGC42105 EPHA6 FAIM3 SIT1 STK32A DNAH7 CNTN6 KISS1R FMN2 MADCAM1 UCHL1 APBB1 C1orf88 CD7 NXF5 TTC23L STX1A CABP1 GRM4 UBASH3A SP140
NCRNA00181 CD247 ACTL6B GRM8 CDX1 CD3E CCL5 ACTG2 NEFM PTPN7 FASLG F2 CPNE4 SPAG6 UCKL1AS ZMYND10 CD3D GNAO1 CD48 DLG4 SH2D1A LOC283663 C9orf43 FAM20A UNC80 FABP1 LINGO2 CCR7 GVIN1 DPPA4 YIPF7 LOC253724 SCG2 GJD2 DES PLAC8L1 LRRC50 C14orf39 HOXD1 GFRA1 TRAT1 NCF1B TSPAN33 CCL21 CPO CD79B LBP TTC9B HP MEP1A GATSL2 MAP6 PRDM12 CD22 CXCR5 BARHL1 NPFFR2 OPRD1 CD27 PI16 ZNF560 FAM169A RUNDC3B IRF4 LRRN3 OR4C6 MLXIPL CELF6 CASC1 FCRL6 MAPK10 SERPINA6 RPRML CCL14 CCDC69 C8orf80 IGFBP2 FAM5C KIF1A ICA1L FFAR1 ZNF467 CD3G GPR21 KLHL6 GPR18 LOC731779 GNG2 P2RY10 FLJ43390 C2orf62 CD52 LTB VIPR2 STAP1 CMTM2 PROK2 GZMA TPPP3 EYS DNAH6 BTLA PAK3 RSPO3 AGBL4 ATCAY GPR65 ACVR1C CRTAC1 KLRC1 FAM57B CD40LG BRSK1 C6orf217 CTSG C1QTNF8 SYNGR4 RIPPLY2 RGS4 NFASC SCML2 TLR10 RHOH MOBP AP3B2 CCR5 LIN7B MAGEL2 IL9R ARHGAP9 GHR ASB2 FAM166A PABPC1L2B DISP2 SNCB TBX21 SLAMF1 PTHLH MUC21 GMFG ARHGAP15 TCL1A ck0014 PGA3 ZNF80 CYTIP GPRASP1 RAET1G IFLTD1 KLRK1 KIT C2orf54 LHFPL4 PCDHB8 ACAP1 RGAG4 LOC285456 SRRM4 CNR1 ORM2 NCR3 LOC100133893 ZGLP1 NKX6-1 SYNM GJD4 XKR4 CD8B PGR LOC642597 GPR158 ZNF683 NEK5 TTLL10 C6orf174 LOC100188949 SCAMP5 NPAS4 ZNF385D HLA-DQB1 IGF1 FEV MTUS2 PYROXD2 PTPRCAP KIAA0748 ATRNL1 S100A12 LOC100130522 FABP2 CHRM2 AFM GIMAP7 DEFA5 FCRLA XCL1 MYO3A FBXL16 RIC3 BLK CD72 C20orf195 LAX1 GIMAP5 GHRL GPR174 ck0012 C1QL4 PATL2 TBX5 CXCL9 APOB ACTN2 FLJ36777 AFF2 PRKCG IRX1 S100A1 CTLA4 CLEC17A CXCL13 APOH CD79A IKZF1 CCDC135 CXorf65 KIF5C PROC C13orf33 UCN3 EFCAB4B NCF1C PLG PENK CLEC10A TCERG1L TP63 TMC8 RCSD1 IL12RB1 CDH19 HLA-DQA1 MS4A1 CXorf49B TNFRSF13B FCRL1 TMEM156 ITK MIA2 TEX11 TMIGD2 CFHR1 MAP4K1 GZMK C15orf59 CD6 C18orf16 FLT3 ZAP70 TRAF3IP3 PRF1 FCRL3 GLYATL3 SLIT1 LOC401387 PEG3 RSPO2 LOC284551 DLL3 DMRTC1B SIRPG HCLS1 ANGPTL1 C6orf58 UNC5D PTGER2 C13orf18 STXBP5L NEURL PCDHA11 FOXF1 RAET1E KIAA0125 XCL2 SRPK3 ENDOU SEMA3D ZP1 MGC14436 ADAMDEC1 ERP27 MT1G BDKRB1 KLHL14 PRRT4 CDH17 FLG SCRT2 LOC200726 FBLN5 RPGRIP1 CD37 CGB8 GUCA2A FCAMR CNTN1 CCR6 KEL CEACAM3 TBC1D10C GPR15 PGA5 TSPAN11 CHD5 RGMA AMHR2 MYH11 LRRIQ1 FAM131C SERPINB13 SASH3 HAND1 PDIA2 ORM1 ASGR2 KREMEN2 FBN3 CXorf30 VPREB3 WAS MGP GDF1 RPTN FCER2 RPL39 LOC100130331 CD1D ISX CLEC4D PAX5 C4orf47 NRG1 C13orf30 SUSD4 FAM78A CST5 MSTN DPF1 CASQ1 SELL FXYD7 PDCD1 LOC254559 PPY ARRDC5 NLRP6 LOC220594 PRKCQ PCDHA4 CHRDL1 C1orf64 LOC401093 GPR97 E2F7 CNNM1 APOA2 NKG7 CADPS CALN1 PSTPIP1 FCRL2 GUCA1C PDK4 MEI1 SPRED3 MT1H PRSS3 FCGR3B FAM129C OSR1 CXCR4 NRCAM CUZD1 CNR2 LIMD2 FAM55D GJA3 CD28 KIAA0319 VIP KBTBD8 FOXJ1 PLEKHN1 SPRR2D DYNLRB2 FAM155B SALL1 PCDH8 NFATC1 LTA PPP1R16B DEFA6 CLEC4C SDK1 MT1M CFP IL2RB FOXN4 TIGIT C4orf49 PARVG C16orf89 GPR78 RSPO1 SSTR1 MS4A8B HLA-DOA PCSK4 DUSP27 A2BP1 C14orf139 C4A CD19 LOC723809 AACSL CST7 PCP2 RNASE6 SLAMF6 C12orf63 LOC91149 POU2F2 PGLYRP2 IKZF3 TACR2 ADAMTS8 GYPE KRT79 CDHR1 LRRK2 DNASE1L3 GATA1 C17orf54 CTNND2 RBPMS2 IL24 GZMM KLK1 RASGRP2 LOC606724 FAM26F PRR7 MS4A14 CCL19 HLA-DOB WIF1 TXNDC3 TIFAB TCEAL2 PTPRC FOSL1 SRL CXorf58 SAMD3 TRIM50 VWA5B1 PKHD1L1 APOC2 EEF1A2 GPR182 MIMT1 FZD9 CNTN2 SH3GL2 TIMD4 GPR55 MUC12 SYN1 NAPSB CEACAM4 SIGLEC10 SYT7 ITM2A MYOCD SCRG1 ART3 CCR4 EOMES MAPK8IP1 TPSAB1 TNFAIP8L3 PPP2R2C BEX1 GDF3 TMEM61 FCRL5 CCL26 ARHGDIG GRHL3 TP53TG3B SCARNA16 TCL6 ZNF114 CD226 LILRB2 C19orf69 AMICA1 ZC3H12D IL33 FYB BRS3 CDH10 RUNX3 ICOS TNIP3 CSF2RB EVI2B MUSK FAM198A C9 GBP6 GALR1 D4S234E ANXA2P3 LY6K CPA3 PGA4 GRPR DPY19L2 SMYD1 RASAL3 ALB LOC389493 KNG1 KIR3DL1 TPSB2 CD53 TMEM52 TCTE1 MYL2 C19orf30 CRYAB KLC3 ALPI CD5 CLEC9A SLITRK2 FLJ35024 GIP LOC728606 MYBPC2 PRSS37 EPO C5orf20 LEFTY2 TNFRSF13C RLBP1 C3orf36 CNN1 LILRB5 CLDN6 MS4A10 YSK4 GBP5 BTK WDFY4 CTRL SLITRK6 IGFL4 BEND4 C1orf114 OR5K2 IL2 MYH1 SERPINA3 CCL16 GP1BA MYRIP RAB39 REG1A RAB39B SERPINB3 TMEM14E NRAP CLECL1 SEC14L5 FAM55A CR2 DAZ1 ITIH4 TMPRSS9 PPBP LOC154822 AKAP7 ZG16 SIGLEC14 FAM107A GREM2 MYBPC1 CETN4P TNFRSF17 C1orf95 C6orf218 LHFPL3 IGF2 CTXN2 C3orf50 FGL1 TXK LILRA3 SPACA3 MATK SORCS1 LRRTM4 EBI3 UBD TNFSF14
NCRNA00173 GGTA1 MGC29506 ODF3L2 FOXD4L6 AGAP2 L1CAM C2orf85 PRKCB CCDC155 P2RY14 GUCA2B SLFN12L S100G ALPPL2 MYL7 PRSS1 IL1RAPL1 LMO3< MLN TNFSF8 LCK GRM5 KIAA1984 CD1C FCER1A UMOD CXorf22 CES4 ADAMTS3 MFAP4 NEK10 COL19A1 NPY1R TNXB COL14A1 ZBBX MYOT TUBB2B REG4 PGLYRP1 CD70 DNASE1 GRM7 TBX10 MS4A15 ERVFRDE1 LOC100233209 CAPN11 CIDEC HLA-DRB5 CXCL11 MYLK2 FGFBP1 ISL2 CD38 SCUBE1 SYT9 KLRF1 DAZL KLK12 NGFR GRIP2 LILRA5 HRG CCR2 CD69 CUX2 HSPB7 IFNG PAX1 GP2 APOBEC3H HSPA6 FABP4 NEFL C14orf64 SNX20 CHL1 PTPN5 RRAD ZBTB32 S100A8 ITGAL MAGEA4 P2RY8 ANKRD55 TRY6 HOXC13 PSMA8 NTRK1 DCAF12L1 CORO1A UTS2 CSDC2 PRIMA1 CLUL1 TAGAP SELP HBD SYCP2L TTLL6 DAZ2 CXCR2 GAPT IL11 OR52N4 FOXB1 TMED6 C8B CGB1 TPTE ABI3BP CLPS SELE C7orf57O The differential genes identified in the transcriptome analysis for TCGA cohort 7 Z The differential metabolism genes identified in the transcriptome analysis for TCGA cohort 7 R The differential metabolites identified in the metabolome analysis for SHCC cohort 7 6 Supplementary Table 1. The detailed DEM and DMG lists. >4 4 5 a :6 6 7 b ?8
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! " # $ % & ' ( ) * + , - . / 0 1 2 3 4 5 6 7 8 9 : ; < = > ? @ A B C D E F G H I J K L M N O P Q R S T U V W X Y Z [ \ ] ^ _ ` a b c d e f g h i j k l m n o p q r s t u v w x y z { | } ~
! " # $ % & ' ( ) * + , - . / 0 1 2 3 4 5 6 7 8 9 : ; < = > ? @ A B C D E F G H I J K L M N O P Q R S T U V W X Y Z [ \ ] ^ _ ` a b c d e f g h i j k l m n o p q r s t u v w x y z { | } ~
! " # $ % & ' ( ) * + , - . / 0 1 2 3 4 5 6 7 8 9 : ; < = > ? @ A B C D E F G H I J K L M N O P Q R S T U V W X Y Z [ \ ] ^ _ ` a b c d e f g h i j k l m n o p q r s t u v w x y z { | } ~ R o o t E n t r y F @lf W o r k b o o k
S u m m a r y I n f o r m a t i o n ( D o c u m e n t S u m m a r y I n f o r m a t i o n 8