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Currency [0]/Explanatory TextG5Explanatory Text % 0Good;Good  a%1 Heading 1G Heading 1 DTj%Dr2 Heading 2G Heading 2 DTj%?3 Heading 3G Heading 3 DTj%234 Heading 49 Heading 4 DTj% 5InputuInput ̙ ??v% 6 Linked CellK Linked Cell }% 7NeutralANeutral  W%3Normal % 8Noteb Note   9OutputwOutput  ???%????????? ???:$Percent ;Title1Title DTj% <TotalMTotal %DrDr= Warning Text? Warning Text %XTableStyleMedium2PivotStyleLight16`pKSheet1SKIPSS-R risk groupCytogenetic risk (IPSS)AgentsIPSS risk group: low:int-1(n)Median age (range) Gender: maledel-5q TD anemia3 "Median time from diagnosis, monthsPrior therapies4Median ANC, 109/LMedian Hb, g/dLMedian RBC U/moMedian ferritin level, ng/mLBM blasts percentageBlast >5% n(%)very lowlowinthigh very highmissingRCUDRCMDRCMD-RSRA MDS-EB (RAEB)5q-MDS-U MDS/MPN-UCMMLGood (favorable) IntermediatePoor (unfavorable & failure)Jabbour E,2017DAC 16:57(73) 70(44-88)NA 0.9(0-31)2(0-10)AZA6:34(40) 70(53-85) 0.6(0-39)3(0-10)overall 22:91(113) 0.7(0-39)Garcia-Manero, G.,20166:22(28) 72.5(51-85) 1.3(0-21.5) 8.6(6.4-13)8:19(27) 70(31-87) 1.8(0.4-30.3) 8.7(6-11.6) 14:41(55) 72(31-87) 1.6(0-30.3) 8.7(6-13)Garcia-Manero, G.,2013DAC-A 12:31(43)67142 3.7(0.2-118)16(n=37)DAC-B7:15(22)7110 3.2(0-51)6(n=27)Overall 19:46(65)6813 3.6(0-118)22(n=64)Thpot, S. 2016 19:29(49)1 71.6(67.2-78.1)6(6-8)1432(1017-1928)AZA+EPO 19:30(49)73.3(62.2-77.6)1512(1003-2130) 38:59(98)1 72.5(62.2-78.1)1472(1003-2130)Grinblatt, D. L., 2015 50:178(228) 75(29-91)3(0-125)64(n=28)Sanchez-Garcia, J. 2018NA(20) 76.1(50-85) 8.8(3-176) 484(78-2000)1.79(0.21-9.76) 8.6(6.8-9.9) 1158(91-7157) Fil, C. 2013 15:17(32) 71(56-84) 20(1-101)4(0-8)Tobiasson, M. 20146:24(30) 69(55-80) 443(23-2313) 1.7(0.3-15.1)1891(220-6230)2(0-9)Sayar, H. 2011NA(14) 69(59-85)4.5(1-9)6(n=14)Median EPO level (U/L) 1.9(0.1-976)5 9.5(5.4-17.3)6 Z 11missing data; 2Mean Age SD; 3RBC or PLT TD; 4Growth factors: ESA, GSCF; 5n=207; 6n=224 !01LMTU WHO Entities MDS-RS (RARS) oAZA-14days oAZA-21days0Supplementary Table 1. 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