ࡱ> e R~bjbjŘG-f-fX%rrrrr8l*4)!&^^^^^zB  O#& rXX" rr^^ vr^r^  ^0._^R  0)!&&&r  )!& 8: Section/topic #Checklist item Reported on page # TITLE Title 1Identify the report as a systematic review, meta-analysis, or both. TitleABSTRACT Structured summary 2Provide a structured summary including, as applicable: background; objectives; data sources; study eligibility criteria, participants, and interventions; study appraisal and synthesis methods; results; limitations; conclusions and implications of key findings; systematic review registration number. Not applicableINTRODUCTION Rationale 3Describe the rationale for the review in the context of what is already known. Introduction Objectives 4Provide an explicit statement of questions being addressed with reference to participants, interventions, comparisons, outcomes, and study design (PICOS). IntroductionMETHODS Protocol and registration 5Indicate if a review protocol exists, if and where it can be accessed (e.g., Web address), and, if available, provide registration information including registration number. Unpublished document circulated to collaboratorsEligibility criteria 6Specify study characteristics (e.g., PICOS, length of follow-up) and report characteristics (e.g., years considered, language, publication status) used as criteria for eligibility, giving rationale. MethodsInformation sources 7Describe all information sources (e.g., databases with dates of coverage, contact with study authors to identify additional studies) in the search and date last searched. MethodsSearch 8Present full electronic search strategy for at least one database, including any limits used, such that it could be repeated. MethodsStudy selection 9State the process for selecting studies (i.e., screening, eligibility, included in systematic review, and, if applicable, included in the meta-analysis). MethodsData collection process 10Describe method of data extraction from reports (e.g., piloted forms, independently, in duplicate) and any processes for obtaining and confirming data from investigators. MethodsData items 11List and define all variables for which data were sought (e.g., PICOS, funding sources) and any assumptions and simplifications made. MethodsRisk of bias in individual studies 12Describe methods used for assessing risk of bias of individual studies (including specification of whether this was done at the study or outcome level), and how this information is to be used in any data synthesis. MethodsSummary measures 13State the principal summary measures (e.g., risk ratio, difference in means). MethodsSynthesis of results 14Describe the methods of handling data and combining results of studies, if done, including measures of consistency (e.g., I2) for each meta-analysis. Methods Page 1 of 2 Section/topic #Checklist item Reported on page # Risk of bias across studies 15Specify any assessment of risk of bias that may affect the cumulative evidence (e.g., publication bias, selective reporting within studies). ResultsAdditional analyses 16Describe methods of additional analyses (e.g., sensitivity or subgroup analyses, meta-regression), if done, indicating which were pre-specified. Methods ResultsRESULTS Study selection 17Give numbers of studies screened, assessed for eligibility, and included in the review, with reasons for exclusions at each stage, ideally with a flow diagram. Methods Figure 1Study characteristics 18For each study, present characteristics for which data were extracted (e.g., study size, PICOS, follow-up period) and provide the citations. Table 1Risk of bias within studies 19Present data on risk of bias of each study and, if available, any outcome level assessment (see item 12). Figure 2-6Results of individual studies 20For all outcomes considered (benefits or harms), present, for each study: (a) simple summary data for each intervention group (b) effect estimates and confidence intervals, ideally with a forest plot. Figure2-6Synthesis of results 21Present results of each meta-analysis done, including confidence intervals and measures of consistency. Table 2Risk of bias across studies 22Present results of any assessment of risk of bias across studies (see Item 15). Figure 7Additional analysis 23Give results of additional analyses, if done (e.g., sensitivity or subgroup analyses, meta-regression [see Item 16]). Table 2DISCUSSION Summary of evidence 24Summarize the main findings including the strength of evidence for each main outcome; consider their relevance to key groups (e.g., healthcare providers, users, and policy makers). DiscussionLimitations 25Discuss limitations at study and outcome level (e.g., risk of bias), and at review-level (e.g., incomplete retrieval of identified research, reporting bias). DiscussionConclusions 26Provide a general interpretation of the results in the context of other evidence, and implications for future research. DiscussionFUNDING Funding 27Describe sources of funding for the systematic review and other support (e.g., supply of data); role of funders for the systematic review. Declared on online submission system From: Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group (2009). Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6(6): e1000097. doi:10.1371/journal.pmed1000097 For more information, visit: www.prisma-statement.org. Page 2 of 2     PRISMA 2009 Checklist  !456<=>?FHxyҺҦwfUfGf3&h.}(B*OJQJ^JnHo(phtHhLCJOJQJ^JaJ h;6h4CJOJQJ^JaJ hLh4CJOJQJ^JaJhLh4OJQJ^J!hLh4B*OJQJ^Jph hLh4CJOJQJ^JaJ&hLh45CJOJQJ\^JaJ/hyYh45B*CJOJQJ\^JaJph)hLh4B*CJOJQJ^JaJph/hLh45B*CJOJQJ\^JaJph!5$If $$Ifa$gdy; $Ifgd U56=>0' $$Ifa$ $Ifgdwkd$$Ifl\] v 4: H(6 (cccccccc0`;64 lap(ccccccccytyU>?FHl_O__$(($Ifa$gdy; (($IfgdyYkdJ$$IflO04:*56 0`;64 lapytyU      ` l m n o ȷܕoȷܕbP>#hLh4OJQJ^JnHo(tH#hLhe˺y˺h hyYhyUCJOJQJ^JaJ&hB*OJQJ^JnHo(phtH#h3B*OJQJ^JnHphtHhyUCJOJQJ^JaJhLhyUOJQJ^J!hLhyUB*OJQJ^Jph#hB*OJQJ^JnHphtH#hn'B*OJQJ^JnHphtH hLhyUCJOJQJ^JaJ aTDTT$(($Ifa$gdyU (($IfgdyUkdv$$IflM\v 5: %)90`;64 laytyUaTDTT$(($Ifa$gdyU (($IfgdyUkd/$$IflB\v 5: %)90`;64 laytyU;>aTDTT$(($Ifa$gdyU (($IfgdyUkd$$IflO\v 5: %)90`;64 laytyU  (/01<=>?TW_ &)QR{{j\h3B*OJQJ^Jph hLhyUCJOJQJ^JaJ&hLhyU5CJOJQJ\^JaJ#h3B*OJQJ^JnHphtHhyUCJOJQJ^JaJ hLhyUCJOJQJ^JaJhLhyUOJQJ^J!hLhyUB*OJQJ^Jphh)eB*OJQJ^Jph&h)eB*OJQJ^JnHo(phtH(0aTDTT$(($Ifa$gdyU (($IfgdyUkd$$IflM\v 5: %)90`;64 laytyU01=>aXL $$Ifa$gdyU $IfgdyUkdZ$$Ifl\v 5: %)90`;64 laytyU>?TW l_O__$(($Ifa$gdyU (($IfgdyUkd/$$IflO05:'69 0`;64 lapytyU&)aTDTT$(($Ifa$gdyU (($IfgdyUkd$$IflB\v 5: %)90`;64 laytyU{|]ghiqrst} пп|o^^^^I)h&_hyUB*CJOJQJ^JaJph hLh4CJOJQJ^JaJhLh4OJQJ^J!hLh4B*OJQJ^Jph hLh4CJOJQJ^JaJ&hLh45CJOJQJ\^JaJhLhyUOJQJ^J!hLhyUB*OJQJ^Jphh3B*OJQJ^Jph hLhyUCJOJQJ^JaJ hyYhyUCJOJQJ^JaJ]haTDTT$(($Ifa$gdyU (($IfgdyUkd$$IflB\v 5: %)90`;64 laytyUhirsaXO $$Ifa$ $Ifgdwkd$$Ifl\v 5: %)90`;64 laytyUst} 1l_O__$(($Ifa$gdy; (($IfgdyYkd\$$IflM05:'69 0`;64 lapytyU01239.vavHH3)hl$h4B*CJOJQJ^JaJph331h;6h4B*CJOJQJ^JaJmHphsH)h Uh4B*CJOJQJ^JaJph)hLh4B*CJOJQJ^JaJph/hLh46B*CJOJQJ]^JaJph!hLh4B*OJQJ^JphhLh4OJQJ^J,hLh4B*OJQJ^JnHo(phtH)h&_hyUB*CJOJQJ^JaJph#hB*CJOJQJ^JaJph 123KXZ[]a_WPHFFF$da$$a$$da$kdB$$Ifl:\v 5: %)90`;64 laytyU./0:;HKWXYZ[\]^_`abcdez{ѳш{soosoosoosooZH=hLhwOJQJ"hLhw5CJ OJQJ\aJ (jhLhwOJQJUmHnHuhLjhLUhLh4OJQJ^J hLh4CJOJQJ^JaJ2h;6hL5>*B*CJ\^JaJmHphcsH:h;6h45>*B*CJOJQJ\^JaJmHphcsH1h;6h4B*CJOJQJ^JaJmHphsH)hl$hl$B*CJOJQJ^JaJph33]^`acd{|}~$da$8^8gd$ {|}~hLh4OJQJ^JhLhw>0P0:p$= /!"#$% DpFŸ]oV:qJFIF XICC_PROFILE HLinomntrRGB XYZ  1acspMSFTIEC sRGB-HP cprtP3desclwtptbkptrXYZgXYZ,bXYZ@dmndTpdmddvuedLview$lumimeas $tech0 rTRC< gTRC< bTRC< textCopyright (c) 1998 Hewlett-Packard CompanydescsRGB IEC61966-2.1sRGB IEC61966-2.1XYZ QXYZ XYZ o8XYZ bXYZ $descIEC http://www.iec.chIEC http://www.iec.chdesc.IEC 61966-2.1 Default RGB colour space - sRGB.IEC 61966-2.1 Default RGB colour space - sRGBdesc,Reference Viewing Condition in IEC61966-2.1,Reference Viewing Condition in IEC61966-2.1view_. \XYZ L VPWmeassig CRT curv #(-27;@EJOTY^chmrw| %+28>ELRY`gnu| &/8AKT]gqz !-8COZfr~ -;HUcq~ +:IXgw'7HYj{+=Oat 2FZn  % : O d y  ' = T j " 9 Q i  * C \ u & @ Z t .Id %A^z &Ca~1Om&Ed#Cc'Ij4Vx&IlAe@e Ek*Qw;c*R{Gp@j>i  A l !!H!u!!!"'"U"""# #8#f###$$M$|$$% %8%h%%%&'&W&&&''I'z''( (?(q(())8)k))**5*h**++6+i++,,9,n,,- -A-v--..L.../$/Z///050l0011J1112*2c223 3F3334+4e4455M555676r667$7`7788P8899B999:6:t::;-;k;;<' >`>>?!?a??@#@d@@A)AjAAB0BrBBC:C}CDDGDDEEUEEF"FgFFG5G{GHHKHHIIcIIJ7J}JK KSKKL*LrLMMJMMN%NnNOOIOOP'PqPQQPQQR1R|RSS_SSTBTTU(UuUVV\VVWDWWX/X}XYYiYZZVZZ[E[[\5\\]']x]^^l^__a_``W``aOaabIbbcCccd@dde=eef=ffg=ggh?hhiCiijHjjkOkklWlmm`mnnknooxop+ppq:qqrKrss]sttptu(uuv>vvwVwxxnxy*yyzFz{{c{|!||}A}~~b~#G k͂0WGrׇ;iΉ3dʋ0cʍ1fΏ6n֑?zM _ɖ4 uL$h՛BdҞ@iءG&vVǥ8nRĩ7u\ЭD-u`ֲK³8%yhYѹJº;.! zpg_XQKFAǿ=ȼ:ɹ8ʷ6˶5̵5͵6ζ7ϸ9к<Ѿ?DINU\dlvۀ܊ݖޢ)߯6DScs 2F[p(@Xr4Pm8Ww)KmAdobedC     $''''$25552;;;;;;;;;;C  ####''',,,BH" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?њ<_pElQfgFߟ^ia]X&%'csFGyѿ?GqM{uO$zO`3}H<3IWM܉+o9ַln,gQ '3).nnFhO=֟P}zVEy杬^EI`Eew}/1)ofz|%?>+мGc+B֡R:*"p78]Km<[aMEBe Y:x.<ocҫpZƪzE a{ cLn1/hPEI)פMiZͰ|&.$db0{ x_U&6}+J1+職mWukt4\|PNy-Zc⊯a=lO3S{n[KGm:+/i y8+l {=qf,jWʵ5FW}06ᕁ&u[sZJz|/WjOUfrlv]--Oe3SW?X.=kTw1-$^칢}/z^C9ϟ}lcjQ@Q@ J?Š(nhH$$If!vh#v #v#vH(#v6:V l (cccccccc0`;6,5 55H(56/ / / /  4p(ccccccccytyU$$If!vh#v*5#v6:V lO 0`;6,5*556/ / 4pytyU$$If!vh#v #v#vH(#v6:V lC0`;65 55H(56/ /  / 4ytyU$$If!vh#v*5#v6:V lO 0`;6,5*556/ / 4pytyU$$If!vh#v #v#vH(#v6:V l*0`;65 55H(56/ /  / 4ytyU$$If!vh#v*5#v6:V lO 0`;6,5*556/ / 4pytyU$$If!vh#v #v#vH(#v6:V lM0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V l80`;65 55H(56/ /  / 4ytyU$$If!vh#v*5#v6:V lO 0`;6,5*556/ / 4pytyU$$If!vh#v #v#vH(#v6:V lB0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V lB0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V lB0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V lB0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V lB0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V lB0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V lB0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V lB0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V lM0`;65 55H(56/ 4ytyU$$If!vh#v #v#vH(#v6:V lD0`;65 55H(56/ 4ytyU,$$If!vh#v #v#v)#va:V l (cccccccc0`;6,5 55%)59/ /  4p(ccccccccytyU$$If!vh#v #v#v)#va:V l?0`;65 55%)59/ / 4ytyU$$If!vh#v #v#v)#va:V l80`;65 55%)59/ /  / 4ytyU$$If!vh#v5#va:V lO 0`;6,5'659/ / 4pytyU$$If!vh#v #v#v)#va:V lB0`;65 55%)59/ 4ytyU$$If!vh#v #v#v)#va:V lB0`;65 55%)59/ 4ytyU$$If!vh#v #v#v)#va:V lM0`;65 55%)59/ 4ytyU$$If!vh#v #v#v)#va:V lB0`;65 55%)59/ 4ytyU$$If!vh#v #v#v)#va:V lO0`;65 55%)59/ 4ytyU$$If!vh#v #v#v)#va:V lM0`;65 55%)59/ 4ytyU$$If!vh#v #v#v)#va:V l0`;65 55%)59/ /  / 4ytyU$$If!vh#v5#va:V lO 0`;6,5'659/ / 4pytyU$$If!vh#v #v#v)#va:V lB0`;65 55%)59/ 4ytyU$$If!vh#v #v#v)#va:V lB0`;65 55%)59/ 4ytyU$$If!vh#v #v#v)#va:V l0`;65 55%)59/ /  / 4ytyU$$If!vh#v5#va:V lM 0`;6,5'659/ / 4pytyU$$If!vh#v #v#v)#va:V l:0`;65 55%)59/  / 4ytyUx2&6FVfv2(&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@66666PJ_HmH nHsH tH8`8 ckeCJ_HaJmH sH tH $A $ ؞k=W[SOBi@B nfhwmc>+4ݭ]`SIC^! \LaW3Zshz~UR;\tꍊdf$YtGQ{Bd(Kp_c?D21@>GR.e1a$n%NݜIxsrRicDKP jdC %R)c55vvZU}ʽ3D;>L7cTEB‹_?~2:Ȅ#kȍO& NkzN8' 0hts@.n6\Vru6k C9W-ù_ A`?^R|{֯A)oViנt] f9dQ)/P yt),b-FO@)$zh O_,"%JJ2 'Pt!h3xbRv;7 ^xO^>K6Veda/޿o_~N&ZS=īzOthrtb'$»Ͻ,:&'rS,Jš(# }o(rzضczbG|%C(njN+Usf{r2q:sGj )T#l|@Q"'Xz;ر zL 6އ!4ɄXTv[9~uzl$ D'ZfV.SGHF.5ΰ.k8.t1]6Kry3vڏPta$LBytC3%{`o ÚQoVۘY;^9®T展b8ZX}1Eh[Z6/H߉ bW`Av f7Oa/>ijFI>͇'6c# B8r_#j}!g5w=Ede 2k EL\D,"jSnno Y=OL75@[Ok}xw|;[.%[>vSg|FfV ed7a]4-׍̾v㺑nd 5#=ч>39t, }#lJN{ pGU` Hx?#á,Dz!%pfc6K:UuVVd1^ q8),rBn(ː0&I$Ae$} Fs+{+,-~@- |[z!8|z]̷}ƴ"Mn+{VBOs:XI{νXج*Έjj<UkEJ]F((f2O:tSn)[30IVOFi^5R{匤YL+b 2e˫yĐ 亭>!`~{`P+&)ƻiXlԮEks:RԖW6;yc]J] AC4=I6`<րOފQ%Z/UZԃJvn֫ðZjϠ(/:;Ɣe/˚\u5{Gڨ]ov;*^7zA=3 ~Jj_ E.5Z4a}14}dj^ PK! ѐ'theme/theme/_rels/themeManager.xml.relsM 0wooӺ&݈Э5 6?$Q ,.aic21h:qm@RN;d`o7gK(M&$R(.1r'JЊT8V"AȻHu}|$b{P8g/]QAsم(#L[PK-![Content_Types].xmlPK-!֧6 0_rels/.relsPK-!kytheme/theme/themeManager.xmlPK-!: theme/theme/theme1.xmlPK-! ѐ' theme/theme/_rels/themeManager.xml.relsPK] ~  $$$$$'o %{.{~%(,049=?A5>  n & 1 /  v--qS0>hs1]~ !"#$&')*+-./1235678:;<>@t ,R$Ÿ]oV:q@@ (    C FA. >>uR`TuR`T>#" `?0(  B S  ? 'Pt OLE_LINK1 OLE_LINK2 OLE_LINK3CKOW0HXZ[]^`acd|XZ[]^`acd|G`}O0H0n%J ,  - 0 q B I J n "%;>(/1W )]XZ[]^`acdez|`m%.00nv%-      q B S (0 ]hii 022WXXZ[[]^`acd|87 Tl$k%n'o(.}(**;6L+7y;*>k? @ELNNPF"R UyU $X1XYyYBZR"d)ej$i~l3r8Uxs,w3*Lv4?@ABCDEFGHIJKMNOPQRSTUVWXYZ\]^_`abcdefghijklmnpqrstuvwxyz{|}~Root Entry F2J_Data L 1Table[&WordDocumentGSummaryInformation(o<DocumentSummaryInformation8CompObjn  FMicrosoft Word 97-2003 ĵ MSWordDocWord.Document.89q