ࡱ>     T8\pDDMisage-8 Ba= =Z38@"1Arial1Calibri1Calibri1Calibri1Arial1*h6 Calibri Light1,6Calibri16Calibri16Calibri1Calibri1Calibri1<Calibri1>Calibri1?Calibri14Calibri14Calibri1 Calibri1 Calibri1Calibri1Calibri1 Calibri1Calibri1Calibri1.Times New Roman"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_)"$"#,##0;\-"$"#,##0"$"#,##0;[Red]\-"$"#,##0"$"#,##0.00;\-"$"#,##0.00#"$"#,##0.00;[Red]\-"$"#,##0.0050_-"$"* #,##0_-;\-"$"* #,##0_-;_-"$"* "-"_-;_-@_-,'_-* #,##0_-;\-* #,##0_-;_-* "-"_-;_-@_-=8_-"$"* #,##0.00_-;\-"$"* #,##0.00_-;_-"$"* "-"??_-;_-@_-4/_-* #,##0.00_-;\-* #,##0.00_-;_-* "-"??_-;_-@_-"Yes";"Yes";"No""True";"True";"False""On";"On";"Off"],[$ -2]\ #,##0.00_);[Red]\([$ -2]\ #,##0.00\)                                                                      ff         P  P        `            a>   H @    ||By}A} 00_)ef[$ -}A} 00_)ef[$ -}A} 00_)ef[$ -}A} 00_)ef[$ -}A} 00_)ef[$ -}A} 00_)ef [$ -}A} 00_)L[$ -}A} 00_)L[$ -}A} 00_)L[$ -}A} 00_)L[$ -}A} 00_)L[$ -}A} 00_)L [$ -}A} 00_)23[$ -}A} 00_)23[$ -}A} 00_)23[$ -}A} 00_)23[$ -}A}  00_)23[$ -}A}! 00_)23 [$ -}A}" 00_)[$ -}A}# 00_)[$ -}A}$ 00_)[$ -}A}% 00_)[$ -}A}& 00_)[$ -}A}' 00_) [$ -}A}( 00_)[$ -}}) }00_)[$ -##0.  }}* 00_)[$ -???##0.??? ??? ???}-}/ 00_)}A}0 a00_)[$ -}A}1 00_)[$ -}A}2 00_)?[$ -}A}3 00_)23[$ -}-}4 00_)}}5 ??v00_)̙[$ -##0.  }A}6 }00_)[$ -}A}7 W00_)[$ -}x}800_)[$##  }}9 ???00_)[$???## ???  ??? ???}-}; 00_)}U}< 00_)[$## }-}= 00_)}<}>00_)[$}<}?00_)[$}}@ 20% - Accent1M 20% - Accent1 ef % 20% - Accent2M" 20% - Accent2 ef % 20% - Accent3M& 20% - Accent3 ef % 20% - Accent4M* 20% - Accent4 ef % 20% - Accent5M. 20% - Accent5 ef % 20% - Accent6M2 20% - Accent6  ef % 40% - Accent1M 40% - Accent1 L % 40% - Accent2M# 40% - Accent2 L˭ % 40% - Accent3M' 40% - Accent3 L % 40% - Accent4M+ 40% - Accent4 L % 40% - Accent5M/ 40% - Accent5 L % 40% - Accent6M3 40% - Accent6  L % 60% - Accent1M 60% - Accent1 23 % 60% - Accent2M$ 60% - Accent2 23 % 60% - Accent3M( 60% - Accent3 23 % 60% - Accent4M, 60% - Accent4 23f % 60% - Accent5M0 60% - Accent5 23 %! 60% - Accent6M4 60% - Accent6  23Ў % "Accent1AAccent1 Dr % #Accent2A!Accent2 }1 % $Accent3A%Accent3  % %Accent4A)Accent4  % &Accent5A-Accent5 [ % 'Accent6A1Accent6  pG %(Bad9Bad  %) Calculation Calculation  }% * Check Cell Check Cell  %????????? ???+ Comma,( Comma [0]-&Currency.. 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Warning Text %XTableStyleMedium2PivotStyleLight16``UKB Summary Stat Files'БSNP Enrichments - DNase Regions%SNP Enrich-Hypergeo-ADULTBIAS%wESNP Enrich-Hypergeo-FETALBIAS%SNP Enrich-Hypergeo-YOUNGBIAS##SNP Enrich-Hypergeo-OLDBIASSNP Enrich - Intersects|LEffect-Size-DistsVPer-SNP Comparisons!vPhastCons Tests + CLINVAR1Genewise Rank TestingҎGenewise Rank Agg HDAC Gene SetS sBroad Category ICD10 Code description gwas_dropboxNEOPLASMC01@Diagnoses - main ICD10: C01 Malignant neoplasm of base of tongueUhttps://www.dropbox.com/s/x6uezrlwkhseku8/C01.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C02WDiagnoses - main ICD10: C02 Malignant neoplasm of other and unspecified parts of tongueUhttps://www.dropbox.com/s/uert2uyz3h2eleg/C02.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C098Diagnoses - main ICD10: C09 Malignant neoplasm of tonsilUhttps://www.dropbox.com/s/92zxxvkxpacw77a/C09.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C15<Diagnoses - main ICD10: C15 Malignant neoplasm of oesophagusUhttps://www.dropbox.com/s/uocxwegublo98dd/C15.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C187Diagnoses - main ICD10: C18 Malignant neoplasm of colonUhttps://www.dropbox.com/s/hf76dddcoabbzst/C18.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C208Diagnoses - main ICD10: C20 Malignant neoplasm of rectumUhttps://www.dropbox.com/s/wdut0i5yl2nnvha/C20.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C22SDiagnoses - main ICD10: C22 Malignant neoplasm of liver and intrahepatic bile ductsUhttps://www.dropbox.com/s/f5tq6q4txfjixiu/C22.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C25:Diagnoses - main ICD10: C25 Malignant neoplasm of pancreasUhttps://www.dropbox.com/s/ladm0rq56hr3wvu/C25.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C34CDiagnoses - main ICD10: C34 Malignant neoplasm of bronchus and lungUhttps://www.dropbox.com/s/q5ux8kt1ock9qdm/C34.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C436Diagnoses - main ICD10: C43 Malignant melanoma of skinUhttps://www.dropbox.com/s/ouxobe9wdmzekmc/C43.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C44=Diagnoses - main ICD10: C44 Other malignant neoplasms of skinUhttps://www.dropbox.com/s/x0vom4ikvh6rka1/C44.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C45(Diagnoses - main ICD10: C45 MesotheliomaUhttps://www.dropbox.com/s/zfi7cfi5pikr4un/C45.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C48PDiagnoses - main ICD10: C48 Malignant neoplasm of retroperitoneum and peritoneumUhttps://www.dropbox.com/s/kg55uomp5245rc2/C48.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C49RDiagnoses - main ICD10: C49 Malignant neoplasm of other connective and soft tissueUhttps://www.dropbox.com/s/ehufsyfe6pqk3cu/C49.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C508Diagnoses - main ICD10: C50 Malignant neoplasm of breastUhttps://www.dropbox.com/s/9ws0r86mgv8sn4r/C50.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C64MDiagnoses - main ICD10: C64 Malignant neoplasm of kidney, except renal pelvisUhttps://www.dropbox.com/s/ktvbeu9027kyiw0/C64.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C679Diagnoses - main ICD10: C67 Malignant neoplasm of bladderUhttps://www.dropbox.com/s/3zcgacq7cfrek7r/C67.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C69@Diagnoses - main ICD10: C69 Malignant neoplasm of eye and adnexaUhttps://www.dropbox.com/s/6l2nzwnkn2j708e/C69.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C717Diagnoses - main ICD10: C71 Malignant neoplasm of brainUhttps://www.dropbox.com/s/1h6l7y2yaik215o/C71.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C73?Diagnoses - main ICD10: C73 Malignant neoplasm of thyroid glandUhttps://www.dropbox.com/s/jrcqqrlipwjx3h8/C73.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C77WDiagnoses - main ICD10: C77 Secondary and unspecified malignant neoplasm of lymph nodesUhttps://www.dropbox.com/s/7u07yhhyr6yje3k/C77.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C80LDiagnoses - main ICD10: C80 Malignant neoplasm without specification of siteUhttps://www.dropbox.com/s/7yok92ymcoz7fhu/C80.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C81-Diagnoses - main ICD10: C81 Hodgkin's diseaseUhttps://www.dropbox.com/s/5psx519kpfahk6p/C81.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C82GDiagnoses - main ICD10: C82 Follicular [nodular] non-Hodgkin's lymphomaUhttps://www.dropbox.com/s/a479x0tqxg7znpx/C82.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0C83:Diagnoses - main ICD10: C83 Diffuse non-Hodgkin's lymphomaUhttps://www.dropbox.com/s/rmysivs558ur9v3/C83.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D045Diagnoses - main ICD10: D04 Carcinoma in situ of skinUhttps://www.dropbox.com/s/him74cqjyx1ea0i/D04.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D057Diagnoses - main ICD10: D05 Carcinoma in situ of breastUhttps://www.dropbox.com/s/b097szma9z1a4af/D05.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D07UDiagnoses - main ICD10: D07 Carcinoma in situ of other and unspecified genital organsUhttps://www.dropbox.com/s/qlubk9flrv1eo1t/D07.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D09LDiagnoses - main ICD10: D09 Carcinoma in situ of other and unspecified sitesUhttps://www.dropbox.com/s/nx2grb9dwyecbqm/D09.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D11DDiagnoses - main ICD10: D11 Benign neoplasm of major salivary glandsUhttps://www.dropbox.com/s/6ggf0d3yrzv07dx/D11.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D12QDiagnoses - main ICD10: D12 Benign neoplasm of colon, rectum, anus and anal canalUhttps://www.dropbox.com/s/bm6r1wxbqvohbnz/D12.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D13^Diagnoses - main ICD10: D13 Benign neoplasm of other and ill-defined parts of digestive systemUhttps://www.dropbox.com/s/ow2um2ahje47q91/D13.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D14PDiagnoses - main ICD10: D14 Benign neoplasm of middle ear and respiratory systemUhttps://www.dropbox.com/s/07eokxpmohfp7cw/D14.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D16KDiagnoses - main ICD10: D16 Benign neoplasm of bone and articular cartilageUhttps://www.dropbox.com/s/radbbkpowmg2k4e/D16.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D176Diagnoses - main ICD10: D17 Benign lipomatous neoplasmUhttps://www.dropbox.com/s/w31fxiih129ddpn/D17.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D18BDiagnoses - main ICD10: D18 Haemangioma and lymphangioma, any siteUhttps://www.dropbox.com/s/4yhy7mnd29kkbdl/D18.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D21VDiagnoses - main ICD10: D21 Other benign neoplasms of connective and other soft tissueUhttps://www.dropbox.com/s/hrfoz4ekw93jbtm/D21.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D22-Diagnoses - main ICD10: D22 Melanocytic naeviUhttps://www.dropbox.com/s/ryx2muopmoafm2w/D22.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D23:Diagnoses - main ICD10: D23 Other benign neoplasms of skinUhttps://www.dropbox.com/s/h18bt4oj81jcsyc/D23.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D245Diagnoses - main ICD10: D24 Benign neoplasm of breastUhttps://www.dropbox.com/s/0viogpvanhxnlnk/D24.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D35UDiagnoses - main ICD10: D35 Benign neoplasm of other and unspecified endocrine glandsUhttps://www.dropbox.com/s/ce9ebycn05jnwdt/D35.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D37jDiagnoses - main ICD10: D37 Neoplasm of uncertain or unknown behaviour of oral cavity and digestive organsUhttps://www.dropbox.com/s/xtir3l3nrlcke2x/D37.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D38}Diagnoses - main ICD10: D38 Neoplasm of uncertain or unknown behaviour of middle ear and respiratory and intrathoracic organsUhttps://www.dropbox.com/s/9c7j0aoxkbgnw6j/D38.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D41XDiagnoses - main ICD10: D41 Neoplasm of uncertain or unknown behaviour of urinary organsUhttps://www.dropbox.com/s/cqhf02bw809qr35/D41.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D43jDiagnoses - main ICD10: D43 Neoplasm of uncertain or unknown behaviour of brain and central nervous systemUhttps://www.dropbox.com/s/04z5xjp6t79zukb/D43.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D45.Diagnoses - main ICD10: D45 Polycythaemia veraUhttps://www.dropbox.com/s/cheyc5kkaqfl1ki/D45.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D465Diagnoses - main ICD10: D46 Myelodysplastic syndromesUhttps://www.dropbox.com/s/m1s598rat469zsf/D46.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D48eDiagnoses - main ICD10: D48 Neoplasm of uncertain or unknown behaviour of other and unspecified sitesUhttps://www.dropbox.com/s/ht4c2vm5fqko09j/D48.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0BLOODD63LDiagnoses - main ICD10: D63 Anaemia in chronic diseases classified elsewhereUhttps://www.dropbox.com/s/1otrczdxs039ogl/D< 63.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0D64*Diagnoses - main ICD10: D64 Other anaemiasUhttps://www.dropbox.com/s/l2aymlgvczmi21u/D64.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0 METABOLICE030Diagnoses - main ICD10: E03 Other hypothyroidismUhttps://www.dropbox.com/s/gnwjnqdiw32n7kh/E03.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0DIABETESE10?Diagnoses - main ICD10: E10 Insulin-dependent diabetes mellitusUhttps://www.dropbox.com/s/yzhl5nnnhwn4tyz/E10.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0E11CDiagnoses - main ICD10: E11 Non-insulin-dependent diabetes mellitusUhttps://www.dropbox.com/s/ugskg6i1oudve5i/E11.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0E23ODiagnoses - main ICD10: E23 Hypofunction and other disorders of pituitary glandUhttps://www.dropbox.com/s/x1ooh3rj02xrz9o/E23.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0E83;Diagnoses - main ICD10: E83 Disorders of mineral metabolismUhttps://www.dropbox.com/s/xe5ha1qm8vtd2u3/E83.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0E87WDiagnoses - main ICD10: E87 Other disorders of fluid, electrolyte and acid-base balanceUhttps://www.dropbox.com/s/yu42y8fcb1kvf0d/E87.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0CVI083Diagnoses - main ICD10: I08 Multiple valve diseasesUhttps://www.dropbox.com/s/z94j84ygyyefj0u/I08.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I10<Diagnoses - main ICD10: I10 Essential (primary) hypertensionUhttps://www.dropbox.com/s/m9hxsj2k5pyxjfw/I10.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I126Diagnoses - main ICD10: I12 Hypertensive renal diseaseUhttps://www.dropbox.com/s/2n035mt0a0eceu6/I12.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I20+Diagnoses - main ICD10: I20 Angina pectorisUhttps://www.dropbox.com/s/1kwz4qez23mz4ho/I20.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I217Diagnoses - main ICD10: I21 Acute myocardial infarctionUhttps://www.dropbox.com/s/8tk8m53ia0lyhs7/I21.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I22<Diagnoses - main ICD10: I22 Subsequent myocardial infarctionUhttps://www.dropbox.com/s/5xwsu138dj9wo1i/I22.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I24@Diagnoses - main ICD10: I24 Other acute ischaemic heart diseasesUhttps://www.dropbox.com/s/k3cpkippv5pqd6t/I24.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I25;Diagnoses - main ICD10: I25 Chronic ischaemic heart diseaseUhttps://www.dropbox.com/s/62kcfsxrsi0slb8/I25.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I26.Diagnoses - main ICD10: I26 Pulmonary embolismUhttps://www.dropbox.com/s/y103kgpw5avw8s1/I26.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I27:Diagnoses - main ICD10: I27 Other pulmonary heart diseasesUhttps://www.dropbox.com/s/m1dmgq8fh2nonhb/I27.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I30.Diagnoses - main ICD10: I30 Acute pericarditisUhttps://www.dropbox.com/s/22lri2nbch57n58/I30.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I319Diagnoses - main ICD10: I31 Other diseases of pericardiumUhttps://www.dropbox.com/s/mw9s4b50liifddd/I31.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I33;Diagnoses - main ICD10: I33 Acute and subacute endocarditisUhttps://www.dropbox.com/s/xxrrvnl8opsx43d/I33.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I34?Diagnoses - main ICD10: I34 Nonrheumatic mitral valve disordersUhttps://www.dropbox.com/s/m2bgypwyp89zkxq/I34.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I35?Diagnoses - main ICD10: I35 Nonrheumatic aortic valve disordersUhttps://www.dropbox.com/s/xrdj7c9kyk01fkb/I35.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I42*Diagnoses - main ICD10: I42 CardiomyopathyUhttps://www.dropbox.com/s/x164s4tlb4vjffe/I42.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I44IDiagnoses - main ICD10: I44 Atrioventricular and left bundle-branch blockUhttps://www.dropbox.com/s/2w21t42v9hgnmsf/I44.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I46*Diagnoses - main ICD10: I46 Cardiac arrestUhttps://www.dropbox.com/s/oxfxj0xxi9mi52o/I46.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I472Diagnoses - main ICD10: I47 Paroxysmal tachycardiaUhttps://www.dropbox.com/s/gtgfepx91wlz497/I47.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I48;Diagnoses - main ICD10: I48 Atrial fibrillation and flutterUhttps://www.dropbox.com/s/uluig1qhvz7veek/I48.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I50)Diagnoses - main ICD10: I50 Heart failureUhttps://www.dropbox.com/s/ruhz8ihfqviok49/I50.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I51WDiagnoses - main ICD10: I51 Complications and ill-defined descriptions of heart diseaseUhttps://www.dropbox.com/s/u3ge0zwbe8fhe48/I51.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I615Diagnoses - main ICD10: I61 Intracerebral haemorrhageUhttps://www.dropbox.com/s/fqjf34x3k5mrsy1/I61.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I63/Diagnoses - main ICD10: I63 Cerebral infarctionUhttps://www.dropbox.com/s/az8jk5wimdl5a76/I63.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I64NDiagnoses - main ICD10: I64 Stroke, not specified as haemorrhage or infarctionUhttps://www.dropbox.com/s/ra0a37einw63ldf/I64.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I65pDiagnoses - main ICD10: I65 Occlusion and stenosis of precerebral arteries, not resulting in cerebral infarctionUhttps://www.dropbox.com/s/vek3n470hhqrzj1/I65.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I70+Diagnoses - main ICD10: I70 AtherosclerosisUhttps://www.dropbox.com/s/4tqxtz02raoscwc/I70.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I71:Diagnoses - main ICD10: I71 Aortic aneurysm and dissectionUhttps://www.dropbox.com/s/9back0r05qe2gnw/I71.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I73>Diagnoses - main ICD10: I73 Other peripheral vascular diseasesUhttps://www.dropbox.com/s/ypt88jof4mg111j/I73.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I74<Diagnoses - main ICD10: I74 Arterial embolism and thrombosisUhttps://www.dropbox.com/s/u9l0bkdzz67pmfk/I74.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I783Diagnoses - main ICD10: I78 Diseases of capillariesUhttps://www.dropbox.com/s/k4kstfzlmrct3wz/I78.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I80:Diagnoses - main ICD10: I80 Phlebitis and thrombophlebitisUhttps://www.dropbox.com/s/3dpobrivnshwpx4/I80.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I82@Diagnoses - main ICD10: I82 Other venous embolism and thrombosisUhttps://www.dropbox.com/s/acrmcsi51iuyexw/I82.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I83?Diagnoses - main ICD10: I83 Varicose veins of lower extremitiesUhttps://www.dropbox.com/s/2tvm6rtktpg1gc7/I83.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I84(Diagnoses - main ICD10: I84 HaemorrhoidsUhttps://www.dropbox.com/s/i45hsvufmes3mfh/I84.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I85/Diagnoses - main ICD10: I85 Oesophageal varicesUhttps://www.dropbox.com/s/4588jysgn48eq1j/I85.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I869Diagnoses - main ICD10: I86 Varicose veins of other sitesUhttps://www.dropbox.com/s/qrwo6x4f2y74h8w/I86.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0I95'Diagnoses - main ICD10: I95 HypotensionUhttps://www.dropbox.com/s/l6mop0r20vgmkyc/I95.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0 RESPIRATORYJ20,Diagnoses - main ICD10: J20 Acute bronchitisUhttps://www.dropbox.com/s/izq83jocvkvc7sq/J20.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0J22IDiagnoses - main ICD10: J22 Unspecified acute lower respiratory infectionUhttps://www.dropbox.com/s/9s599u04mmfxu9h/J22.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0J40IDiagnoses - main ICD10: J40 Bronchitis, not specified as acute or chronicUhttps://www.dropbox.com/s/5njtic3kebvlt9q/J40.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0J44GDiagnoses - main ICD10: J44 Other chronic obstructive pulmonary diseaseUhttps://www.dropbox.com/s/3rew23t30emmv8b/J44.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0J47*Diagnoses - main ICD10: J47 BronchiectasisUhttps://www.dropbox.com/s/t8cwz0lk4tixb3x/J47.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0J84ADiagnoses - main ICD10: J84 Other interstitial pulmonary diseasesUhttps://www.dropbox.com/s/kz8sn803afje98o/J84.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0 DIGESTIVEK25)Diagnoses - main ICD10: K25 Gastric ulcerUhttps://www.dropbox.com/s/g8frbf9970a0mx5/K25.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0K26*Diagnoses - main ICD10: K26 Duodenal ulcerUhttps://www< .dropbox.com/s/6xxymem0j2i1uau/K26.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0K294Diagnoses - main ICD10: K29 Gastritis and duodenitisUhttps://www.dropbox.com/s/xstcpf92oevsgwa/K29.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0K763Diagnoses - main ICD10: K76 Other diseases of liverUhttps://www.dropbox.com/s/m7asy255baaoqbk/K76.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0K85.Diagnoses - main ICD10: K85 Acute pancreatitisUhttps://www.dropbox.com/s/nap6s5mr3u24k35/K85.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0MUSCULOSKELETALM00.Diagnoses - main ICD10: M00 Pyogenic arthritisUhttps://www.dropbox.com/s/lchjttd55rr2won/M00.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M05=Diagnoses - main ICD10: M05 Seropositive rheumatoid arthritisUhttps://www.dropbox.com/s/dh4bi6te3brqtkh/M05.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M066Diagnoses - main ICD10: M06 Other rheumatoid arthritisUhttps://www.dropbox.com/s/nhfn3uemqiy3svl/M06.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M10 Diagnoses - main ICD10: M10 GoutUhttps://www.dropbox.com/s/7l26kh3kfduu7gh/M10.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M13+Diagnoses - main ICD10: M13 Other arthritisUhttps://www.dropbox.com/s/e1s9ff2d8toh5c4/M13.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M15)Diagnoses - main ICD10: M15 PolyarthrosisUhttps://www.dropbox.com/s/9hmqby1yrn5sob9/M15.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M16;Diagnoses - main ICD10: M16 Coxarthrosis [arthrosis of hip]Uhttps://www.dropbox.com/s/lls1kahhyz5pyz7/M16.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M17<Diagnoses - main ICD10: M17 Gonarthrosis [arthrosis of knee]Uhttps://www.dropbox.com/s/e97gk2c7a6grze4/M17.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M18DDiagnoses - main ICD10: M18 Arthrosis of first carpometacarpal jointUhttps://www.dropbox.com/s/xljouf0tx9dvvh8/M18.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M19+Diagnoses - main ICD10: M19 Other arthrosisUhttps://www.dropbox.com/s/2n3hk7gajs7aefg/M19.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M452Diagnoses - main ICD10: M45 Ankylosing spondylitisUhttps://www.dropbox.com/s/mumyyl07ec2r9ff/M45.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M46>Diagnoses - main ICD10: M46 Other inflammatory spondylopathiesUhttps://www.dropbox.com/s/v2tegdiohogctds/M46.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M47'Diagnoses - main ICD10: M47 SpondylosisUhttps://www.dropbox.com/s/ho51egxddjiqpf2/M47.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M481Diagnoses - main ICD10: M48 Other spondylopathiesUhttps://www.dropbox.com/s/8cw18ee50kzwcpl/M48.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M657Diagnoses - main ICD10: M65 Synovitis and tenosynovitisUhttps://www.dropbox.com/s/jc1a5z12e2t8vok/M65.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M67BDiagnoses - main ICD10: M67 Other disorders of synovium and tendonUhttps://www.dropbox.com/s/m6dwylld9p4rlha/M67.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M80CDiagnoses - main ICD10: M80 Osteoporosis with pathological fractureUhttps://www.dropbox.com/s/aqw9v43b627ob28/M80.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0M81FDiagnoses - main ICD10: M81 Osteoporosis without pathological fractureUhttps://www.dropbox.com/s/q6m21s1olbbs0bw/M81.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0N17/Diagnoses - main ICD10: N17 Acute renal failureUhttps://www.dropbox.com/s/ed39zhcmjm5mm7r/N17.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0N181Diagnoses - main ICD10: N18 Chronic renal failureUhttps://www.dropbox.com/s/a22owffzyj6gh5q/N18.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0N195Diagnoses - main ICD10: N19 Unspecified renal failureUhttps://www.dropbox.com/s/ji1alxj5jv7gwu8/N19.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0N209Diagnoses - main ICD10: N20 Calculus of kidney and ureterUhttps://www.dropbox.com/s/o9y0adkj028atfs/N20.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0N28ZDiagnoses - main ICD10: N28 Other disorders of kidney and ureter, not elsewhere classifiedUhttps://www.dropbox.com/s/vtlaqoeqe39tt39/N28.gwas.imputed_v3.both_sexes.tsv.bgz?dl=0Disease$Significance Thresholded SNPs NearbyAAverage Background Counts of Nearby Significance-Thresholded SNPsSD Background Valuesz_scorepvalpadj direction MUSCULOSKELETAL_M46 enrichment MUSCULOSKELETAL_M19 MUSCULOSKELETAL_M67 MUSCULOSKELETAL_M17 MUSCULOSKELETAL_M00 MUSCULOSKELETAL_M45 MUSCULOSKELETAL_M16 MUSCULOSKELETAL_M18 MUSCULOSKELETAL_M65 MUSCULOSKELETAL_M48 MUSCULOSKELETAL_M10 MUSCULOSKELETAL_M47 MUSCULOSKELETAL_M13 MUSCULOSKELETAL_M15 MUSCULOSKELETAL_M81 DIGESTIVE_K76 DIGESTIVE_K29 DIGESTIVE_K26 DIGESTIVE_K25 DIGESTIVE_K85 NEOPLASM_C83 NEOPLASM_D23 NEOPLASM_D14 NEOPLASM_C50 NEOPLASM_D12 NEOPLASM_C34 NEOPLASM_C67 NEOPLASM_C18 NEOPLASM_D45 NEOPLASM_D09 NEOPLASM_D24 NEOPLASM_D48 NEOPLASM_C45 NEOPLASM_C01 NEOPLASM_C73 NEOPLASM_C81 NEOPLASM_C77 NEOPLASM_C69 NEOPLASM_C15 NEOPLASM_D04 NEOPLASM_C43 NEOPLASM_D21 NEOPLASM_D37 NEOPLASM_C09 NEOPLASM_C49 NEOPLASM_C20 NEOPLASM_D05 NEOPLASM_D18 NEOPLASM_D17 NEOPLASM_D13 NEOPLASM_D22 NEOPLASM_C71 NEOPLASM_D41 NEOPLASM_C80 NEOPLASM_D46 NEOPLASM_C64 NEOPLASM_D07 NEOPLASM_C48 NEOPLASM_C02 NEOPLASM_D35 NEOPLASM_D16 NEOPLASM_D38 NEOPLASM_D43 NEOPLASM_D11 DIABETES_N17 DIABETES_N19 DIABETES_N28 DIABETES_N20 DIABETES_N18 DIABETES_E11 METABOLIC_E83 METABOLIC_E03 METABOLIC_E87 METABOLIC_E23 BLOOD_D63 RESPIRATORY_J84 RESPIRATORY_J47 RESPIRATORY_J44 RESPIRATORY_J22 RESPIRATORY_J20 RESPIRATORY_J40 CV_I12 CV_I71 CV_I64 CV_I51 CV_I26 CV_I35 CV_I48 CV_I44 CV_I65 CV_I46 CV_I34 CV_I21 CV_I85 CV_I25 CV_I24 CV_I22 CV_I20 CV_I31 CV_I30 CV_I73 CV_I10 CV_I80 CV_I82 CV_I42 CV_I86 CV_I74 CV_I63 CV_I78 CV_I47 CV_I83 CV_I70 CV_I27 CV_I50 CV_I61 CV_I84 CV_I33 CV_I08 CV_I95 NEOPLASM_C25 BLOOD_D64 MUSCULOSKELETAL_M80 depletion MUSCULOSKELETAL_M06 MUSCULOSKELETAL_M05 DIABETES_E10 NEOPLASM_C82 NEOPLASM_C44traitFC1Number Target Regions w/nearby Thresholded SNP(s)Total # of Target Regions % Targets5Number Background Regions w/nearby Thresholded SNP(s)Total # of Background Regions % BackgroundHypergeometric test p-value$Hypergeometric test adjusted p-value Direction NEOPLASM_D17enrich NEOPLASM_C77 NEOPLASM_C43 DIABETES_N18 DIGESTIVE_K85MUSCULOSKELETAL_M18MUSCULOSKELETAL_M06RESPIRATORY_J22CV_I20 NEOPLASM_D35 NEOPLASM_C83CV_I47CV_I74 NEOPLASM_D23CV_I63MUSCULOSKELETAL_M67 NEOPLASM_C67MUSCULOSKELETAL_M47 DIGESTIVE_K25CV_I84 NEOPLASM_D04CV_I70CV_I44 NEOPLASM_D22CV_I21 NEOPLASM_D18 NEOPLASM_C71MUSCULOSKELETAL_M81MUSCULOSKELETAL_M13CV_I65 NEOPLASM_D05RESPIRATORY_J44CV_I64CV_I24 NEOPLASM_C82MUSCULOSKELETAL_M19CV_I71CV_I95 DIGESTIVE_K26 NEOPLASM_D11MUSCULOSKELETAL_M46 NEOPLASM_C48MUSCULOSKELETAL_M48 NEOPLASM_D46CV_I10RESPIRATORY_J47CV_I73 METABOLIC_E87 DIABETES_E10CV_I42 NEOPLASM_C02CV_I61 NEOPLASM_D16 NEOPLASM_D48CV_I26CV_I50 NEOPLASM_C80CV_I78CV_I34CV_I22 DIGESTIVE_K76 DIABETES_N20CV_I30 NEOPLASM_D37CV_I33 NEOPLASM_C20 NEOPLASM_C25CV_I12 BLOOD_D64 NEOPLASM_D13 NEOPLASM_C09CV_I31CV_I51 NEOPLASM_D24 NEOPLASM_D09 NEOPLASM_D41 DIABETES_N19MUSCULOSKELETAL_M15CV_I85 NEOPLASM_C15 NEOPLASM_D07 NEOPLASM_D43MUSCULOSKELETAL_M05 NEOPLASM_C34CV_I86 NEOPLASM_C49RESPIRATORY_J84MUSCULOSKELETAL_M45 DIABETES_E11CV_I08 NEOPLASM_D45CV_I82 DIABETES_N17 DIABETES_N28MUSCULOSKELETAL_M80 NEOPLASM_C81MUSCULOSKELETAL_M10 METABOLIC_E23CV_I80 METABOLIC_E03 NEOPLASM_C73CV_I46CV_I27 NEOPLASM_D38 NEOPLASM_C69 NEOPLASM_C45 NEOPLASM_D14 NEOPLASM_C01RESPIRATORY_J40MUSCULOSKELETAL_M16 NEOPLASM_D21MUSCULOSKELETAL_M65 NEOPLASM_C44 BLOOD_D63MUSCULOSKELETAL_M00 DIGESTIVE_K29MUSCULOSKELETAL_M17 METABOLIC_E83 NEOPLASM_C18 NEOPLASM_C64< CV_I35RESPIRATORY_J20CV_I25 NEOPLASM_D12CV_I83depleted NEOPLASM_C50CV_I48#ADDITIONAL DEVELOPMENTAL TRAIT GWAS birth_length BW_maternal child_BMI child_epi cong_stomachBW_fetal gest_durationhoshi_BWpuberty_growthheightLONGEVITY GWAS father_age lifegen_age mother_age combo_ageTrait% TargetHypergeometric adjusted p-valueSignificance-Thresholded SNPsW_statW_PvalCV.I48 NEOPLASM.C50CV.I83 DIABETES.E10 NEOPLASM.D04CV.I86CV.I80MUSCULOSKELETAL.M06 NEOPLASM.D48RESPIRATORY.J84 NEOPLASM.C43CV.I30CV.I25MUSCULOSKELETAL.M45 DIABETES.N20 NEOPLASM.C73CV.I51 NEOPLASM.C01 NEOPLASM.D05MUSCULOSKELETAL.M47CV.I46 NEOPLASM.D24 NEOPLASM.D11CV.I35CV.I20CV.I84MUSCULOSKELETAL.M16 NEOPLASM.C69CV.I27 NEOPLASM.D22MUSCULOSKELETAL.M18CV.I70MUSCULOSKELETAL.M17CV.I61 DIABETES.E11 NEOPLASM.C77 DIABETES.N19 NEOPLASM.C45 NEOPLASM.D14 NEOPLASM.D16 DIABETES.N17 BLOOD.D63CV.I73MUSCULOSKELETAL.M13MUSCULOSKELETAL.M67 METABOLIC.E83MUSCULOSKELETAL.M05CV.I82 DIGESTIVE.K85 NEOPLASM.D17 DIGESTIVE.K29MUSCULOSKELETAL.M00CV.I74CV.I10CV.I26MUSCULOSKELETAL.M19MUSCULOSKELETAL.M46 NEOPLASM.C34 NEOPLASM.C80 NEOPLASM.D38RESPIRATORY.J44 BLOOD.D64 NEOPLASM.D23 NEOPLASM.D45 METABOLIC.E23CV.I50 NEOPLASM.D21CV.I71 DIGESTIVE.K25MUSCULOSKELETAL.M15 NEOPLASM.C82MUSCULOSKELETAL.M81 METABOLIC.E03CV.I24CV.I12 METABOLIC.E87 NEOPLASM.D13 NEOPLASM.D46CV.I63 DIABETES.N28MUSCULOSKELETAL.M10 NEOPLASM.C18 NEOPLASM.C67 NEOPLASM.C83 NEOPLASM.D07RESPIRATORY.J40MUSCULOSKELETAL.M48MUSCULOSKELETAL.M80CV.I21CV.I85 DIGESTIVE.K26 NEOPLASM.C20 NEOPLASM.C64 NEOPLASM.D41 NEOPLASM.D43RESPIRATORY.J22 NEOPLASM.C44 NEOPLASM.D12CV.I08RESPIRATORY.J47CV.I47 NEOPLASM.D35 NEOPLASM.C09 DIGESTIVE.K76CV.I34 NEOPLASM.D37RESPIRATORY.J20 NEOPLASM.C25CV.I64CV.I42 DIABETES.N18CV.I95 NEOPLASM.D18CV.I65CV.I78 NEOPLASM.C81MUSCULOSKELETAL.M65 NEOPLASM.C71CV.I44 NEOPLASM.C15CV.I22CV.I31CV.I33 NEOPLASM.C02 NEOPLASM.C48 NEOPLASM.C49All SNPsBLOOD.WBLOOD.W1CV.WCV.W1CV.W2CV.W3CV.W4CV.W5CV.W6CV.W7CV.W8CV.W9CV.W10CV.W11NACV.W12CV.W13CV.W14CV.W15CV.W16CV.W17CV.W18CV.W19CV.W20CV.W21CV.W22CV.W23CV.W24CV.W25CV.W26CV.W27CV.W28CV.W29CV.W30CV.W31CV.W32CV.W33CV.W34CV.W35CV.W36CV.W37 DIABETES.W DIABETES.W1 DIABETES.W2 DIABETES.W3 DIABETES.W4 DIABETES.W5 DIABETES.W6 DIGESTIVE.W DIGESTIVE.W1 DIGESTIVE.W2 DIGESTIVE.W3 DIGESTIVE.W4 METABOLIC.W METABOLIC.W1 METABOLIC.W2 METABOLIC.W3MUSCULOSKELETAL.WMUSCULOSKELETAL.W1MUSCULOSKELETAL.W2MUSCULOSKELETAL.W3MUSCULOSKELETAL.W4MUSCULOSKELETAL.W5MUSCULOSKELETAL.W6MUSCULOSKELETAL.W7MUSCULOSKELETAL.W8MUSCULOSKELETAL.W9MUSCULOSKELETAL.W10MUSCULOSKELETAL.W11MUSCULOSKELETAL.W12MUSCULOSKELETAL.W13MUSCULOSKELETAL.W14MUSCULOSKELETAL.W15MUSCULOSKELETAL.W16MUSCULOSKELETAL.W17 NEOPLASM.W NEOPLASM.W1 NEOPLASM.W2 NEOPLASM.W3 NEOPLASM.W4 NEOPLASM.W5 NEOPLASM.W6 NEOPLASM.W7 NEOPLASM.W8 NEOPLASM.W9 NEOPLASM.W10 NEOPLASM.W11 NEOPLASM.W12 NEOPLASM.W13 NEOPLASM.W14 NEOPLASM.W15 NEOPLASM.W16 NEOPLASM.W17 NEOPLASM.W18 NEOPLASM.W19 NEOPLASM.W20 NEOPLASM.W21 NEOPLASM.W22 NEOPLASM.W23 NEOPLASM.W24 NEOPLASM.W25 NEOPLASM.W26 NEOPLASM.W27 NEOPLASM.W28 NEOPLASM.W29 NEOPLASM.W30 NEOPLASM.W31 NEOPLASM.W32 NEOPLASM.W33 NEOPLASM.W34 NEOPLASM.W35 NEOPLASM.W36 NEOPLASM.W37 NEOPLASM.W38 NEOPLASM.W39 NEOPLASM.W40 NEOPLASM.W41 NEOPLASM.W42 NEOPLASM.W43 NEOPLASM.W44 NEOPLASM.W45 NEOPLASM.W46 RESPIRATORY.WRESPIRATORY.W1RESPIRATORY.W2RESPIRATORY.W3RESPIRATORY.W4RESPIRATORY.W5@Development Region Set Testing: Cross-Disease Association Metric Comparison DifferenceLower bound of 95%CIUpper bound of 95% CIAdjusted p-value"Direction (wrt first item in pair)4Development Region Set Testing: Per-SNP phyloP20ways<Development Region Set Testing: Per-SNP estimated allele age/Development Region Set Testing: LINSIGHT ScoresPDevelopment + Aging-Altered Region Set Testing: Cross-Disease Association MetricDDevelopment + Aging-Altered Region Set Testing: Per-SNP phyloP20waysLDevelopment + Aging-Altered Region Set Testing: Per-SNP estimated allele age?Development + Aging-Altered Region Set Testing: LINSIGHT ScoresGenome-wide Variants:)PHAST_MEAN_cross-trait-association-metric.NOT_PHAST_MEAN_cross-trait-association-metric wilcox_stat wilcox_pvalCLINVAR Variant Testing:TypeDIRstand_pzscore target_val mean_back_val ZSCORE_25ENRICH ZSCORE_Mean ZSCORE_75 PHYLOP_25 PHYLOP_Mean PHYLOP_75 ARGWEAVER_25DEPLETEARGWEAVER_Mean ARGWEAVER_75 LINSIGHT25< -1e4 LINSIGHTMean LINSIGHT75GO Homeostatic Processes Target Mean Target SDBackground Mean Background SD T-statisticT-test p-valueGO Development of ReproductionGENOMEWIDE  RRAID Description GeneRatioBgRatiopvaluep.adjustqvalueCountGENE GO:0007215$glutamate receptor signaling pathway34/1712 101/157566818/23236/2915/5923/1612/388336/2898/22871/2895/2904/81831/27091/2899/3458/57554/8787/22941/59284/2913/2917/54800/2903/2893/9456/5649/154/2534/7074/1739/10369/10891/2776/2892/351SULT1A3/PLCB1/GRM5/RASGRF1/DAPK1/SHISA6/GRIK2/NLGN1/GRID2/GRIN2B/NETO2/CACNG5/GRIK3/IFNG/LRRC7/RGS9/SHANK2/CACNG7/GRM3/GRM7/KLHL24/GRIN2A/GRIA4/HOMER1/RELN/ADRB2/FYN/TIAM1/DLG1/CACNG2/PPARGC1A/GNAQ/GRIA3/APP GO:0050808synapse organization84/1712 415/15756116442/4983/26115/4204/3643/5063/23316/10243/5747/40/1287/2915/55906/57689/23544/23114/389941/388336/1496/7143/4009/22871/140689/1139/5800/158866/2895/55737/6092/5764/84966/2904/2043/54549/26037/85461/153090/22865/9863/8936/10810/22941/6529/8499/55607/783/288/347902/91752/84189/25978/1826/2066/27253/145581/6585/1607/5217/57497/9456/9423/2047/5649/2596/3556/2534/7074/1739/10369/1007/55638/9723/2562/139065/66000/7534/22891/4915/347731/1000/2239/351/375323/1006RAB39B/OPHN1/TANC2/MECP2/INSR/PAK3/CUX2/GPHN/PTK2/ASIC2/COL4A5/GRM5/ZC4H2/LRRC4C/SEZ6L/NFASC/C1QL3/SHISA6/CTNNA2/TNR/LMX1A/NLGN1/CBLN4/CHRNA7/PTPRO/ZDHHC15/GRID2/VPS35/ROBO2/PTN/IGSF21/GRIN2B/EPHA4/SDK2/SIPA1L1/TANC1/DAB2IP/SLITRK3/MAGI2/WASF1/WASF3/SHANK2/SLC6A1/PPFIA2/PPP1R9A/CACNB2/ANK3/AMIGO2/ZNF804A/SLITRK6/CHMP2B/DSCAM/ERBB4/PCDH17/LRFN5/SLIT1/DGKB/PFN2/LRFN2/HOMER1/NTN1/EPHB1/RELN/GAP43/IL1RAP/FYN/TIAM1/DLG1/CACNG2/CDH9/SYBU/SEMA3E/GABRB3/SLITRK4/TMEM108/YWHAZ/ZNF365/NTRK2/LRRTM3/CDH2/GPC4/APP/LHFPL4/CDH8 GO:00996010regulation of neurotransmitter receptor activity27/171278/157565923/22839/1612/388336/22871/2904/81831/27091/3458/57554/9229/8787/4885/22941/59284/54800/2903/2893/9456/5649/154/130574/1739/10369/10891/2892/351RASGRF1/DLGAP4/DAPK1/SHISA6/NLGN1/GRIN2B/NETO2/CACNG5/IFNG/LRRC7/DLGAP1/RGS9/NPTX2/SHANK2/CACNG7/KLHL24/GRIN2A/GRIA4/HOMER1/RELN/ADRB2/LYPD6/DLG1/CACNG2/PPARGC1A/GRIA3/APP GO:0034765)regulation of ion transmembrane transport85/1712 452/15756653519/1193/5174/23204/51463/65267/65125/40/2915/144245/1756/196527/1536/775/5923/5243/1612/23072/388336/3773/22871/3760/56479/90134/799/6334/2904/348980/81831/5142/27091/3768/3458/57554/3763/8787/22941/3751/783/288/3779/84329/777/57620/9472/59284/781/54800/776/2903/126755/1804/2702/3759/3736/6262/2893/1131/9456/5649/154/10345/2259/91404/23327/130497/2534/1739/10971/10369/10891/57628/11060/2475/56659/23704/3737/84502/3738/6769/283518/2892/351/117531/3739GPR89A/CLIC2/PDZK1/ARL6IP1/GPR89B/WNK3/WNK1/ASIC2/GRM5/ALG10B/DMD/ANO6/CYBB/CACNA1C/RASGRF1/ABCB1/DAPK1/HECW1/SHISA6/KCNJ16/NLGN1/KCNJ3/KCNQ5/KCNH7/CALCR/SCN8A/GRIN2B/HCN1/NETO2/PDE4B/CACNG5/KCNJ12/IFNG/LRRC7/KCNJ6/RGS9/SHANK2/KCND2/CACNB2/ANK3/KCNMB1/HVCN1/CACNA1E/STIM2/AKAP6/CACNG7/CACNA2D1/KLHL24/CACNA1D/GRIN2A/LRRC38/DPP6/GJA5/KCNJ2/KCNA1/RYR2/GRIA4/CHRM3/HOMER1/RELN/ADRB2/T< RDN/FGF14/SESTD1/NEDD4L/OSR1/FYN/DLG1/YWHAQ/CACNG2/PPARGC1A/DPP10/WWP2/MTOR/KCNK13/KCNE4/KCNA2/JPH4/KCNA3/STAC/KCNRG/GRIA3/APP/TMC1/KCNA4 GO:0032409"regulation of transporter activity55/1712 258/15756+1193/5174/65267/65125/2915/144245/1756/5923/5243/1612/23072/388336/22871/154881/2904/81831/5142/27091/54602/3458/57554/8787/22941/783/288/57620/9472/59284/781/54800/776/2903/126755/6446/3736/6262/2893/1131/9456/5649/154/10345/2259/23327/130497/1739/10369/10891/11060/23704/84502/6769/283518/2892/351NCLIC2/PDZK1/WNK3/WNK1/GRM5/ALG10B/DMD/RASGRF1/ABCB1/DAPK1/HECW1/SHISA6/NLGN1/KCTD7/GRIN2B/NETO2/PDE4B/CACNG5/NDFIP2/IFNG/LRRC7/RGS9/SHANK2/CACNB2/ANK3/STIM2/AKAP6/CACNG7/CACNA2D1/KLHL24/CACNA1D/GRIN2A/LRRC38/SGK1/KCNA1/RYR2/GRIA4/CHRM3/HOMER1/RELN/ADRB2/TRDN/FGF14/NEDD4L/OSR1/DLG1/CACNG2/PPARGC1A/WWP2/KCNE4/JPH4/STAC/KCNRG/GRIA3/APP GO:0099177&regulation of trans-synaptic signaling82/1712 441/15756321/4983/1269/4204/23316/23096/23236/2915/64854/57689/5923/22839/23228/6857/388336/7143/2898/22871/5332/1139/10718/2895/57282/5764/6616/2904/22986/2043/26037/27091/2899/116/9229/4885/22941/2171/107/6529/8499/84062/55607/783/488/3269/59284/2913/2917/1956/6507/10814/9590/776/2903/27253/3274/1607/5217/57497/9456/2047/5649/154/9693/9515/1129/2259/4887/2534/10369/594857/8526/57537/2475/55638/1268/84502/66000/5030/4915/1000/351/7101APBA2/OPHN1/CNR2/MECP2/CUX2/IQSEC2/PLCB1/GRM5/USP46/LRRC4C/RASGRF1/DLGAP4/PLCL2/SYT1/SHISA6/TNR/GRIK2/NLGN1/PLCB4/CHRNA7/NRG3/GRID2/SLC4A10/PTN/SNAP25/GRIN2B/SORCS3/EPHA4/SIPA1L1/CACNG5/GRIK3/ADCYAP1/DLGAP1/NPTX2/SHANK2/FABP5/ADCY1/SLC6A1/PPFIA2/DTNBP1/PPP1R9A/CACNB2/ATP2A2/HRH1/CACNG7/GRM3/GRM7/EGFR/SLC1A3/CPLX2/AKAP12/CACNA1D/GRIN2A/PCDH17/HRH2/DGKB/PFN2/LRFN2/HOMER1/EPHB1/RELN/ADRB2/RAPGEF2/STXBP5L/CHRM2/FGF14/NPY2R/FYN/CACNG2/NPS/DGKE/SORCS2/MTOR/SYBU/CNR1/JPH4/TMEM108/P2RY4/NTRK2/CDH2/APP/NR2E1 GO:0007608sensory perception of smell73/1712 392/1575679501/81061/81399/390538/283694/440153/79334/441669/441670/390429/401427/26682/391211/343563/390431/127068/127069/127077/401993/441308/403244/401994/403239/343173/401992/283093/346528/283092/79544/81328/341359/219464/390649/390167/119749/79317/390168/219437/219438/403253/81327/158046/219432/26338/390142/338675/390154/390144/390155/89797/81309/219431/390648/219436/390151/219428/4685/219429/2535/81318/219469/81168/26696/219493/219484/282770/81300/219487/338674/390181/219447/390113/120586OR4F5/OR11H1/OR4F16/OR4M2/OR4N4/OR11H12/OR11H2/OR4Q3/OR4M1/OR4N2/OR2A7/OR4F4/OR2G6/OR2T29/OR4K2/OR2T34/OR2T10/OR2T11/OR2T5/OR4F21/OR2T35/OR14I1/OR2T27/OR2T3/OR2T2/OR4C12/OR2A1/OR4C13/OR4K1/OR4A15/SYT10/OR5T2/OR4F15/OR5M10/OR4C46/OR4K5/OR5M1/OR5L1/OR5D18/OR4A47/OR4A16/NXNL2/OR4C6/OR5L2/OR5D13/OR5AP2/OR5T3/OR5D16/OR5T1/NAV2/OR4C15/OR4S2/OR4F6/OR5D14/OR8H2/OR4C16/NCAM2/OR4C11/FZD2/OR4A5/OR8H1/OR8J3/OR2T1/OR5AR1/OR5M8/OR10AG1/OR4P4/OR5M11/OR5F1/OR5AK2/OR5AS1/OR4X1/OR8I2 GO:0050807"regulation of synapse organization47/1712 217/1575626115/5063/23316/5747/40/389941/388336/1496/22871/5800/158866/2895/55737/6092/5764/2904/2043/26037/153090/22865/8499/55607/347902/91752/84189/25978/145581/6585/1607/57497/9456/9423/2047/5649/2596/3556/2534/7074/139065/7534/4915/347731/1000/2239/351/375323/1006#TANC2/PAK3/CUX2/PTK2/ASIC2/C1QL3/SHISA6/CTNNA2/NLGN1/PTPRO/ZDHHC15/GRID2/VPS35/ROBO2/PTN/GRIN2B/EPHA4/SIPA1L1/DAB2IP/SLITRK3/PPFIA2/PPP1R9A/AMIGO2/ZNF804A/SLITRK6/CHMP2B/LRFN5/SLIT1/DGKB/LRFN2/HOMER1/NTN1/EPHB1/RELN/GAP43/IL1RAP/FYN/TIAM1/SLITRK4/YWHAZ/NTRK2/LRRTM3/CDH2/GPC4/APP/LHFPL4/CDH8 GO:0050803+regulation of synapse structure or activity48/1712 228/15756 26115/5063/23316/5747/40/389941/388336/1496/22871/5800/158866/2895/55737/6092/5764/2904/2043/26037/153090/22865/8499/55607/347902/91752/84189/25978/145581/6585/1607/57497/9456/9423/2047/5649/2596/3556/2534/7074/55638/139065/7534/4915/347731/1000/2239/351/375323/1006(TANC2/PAK3/CUX2/PTK2/ASIC2/C1QL3/SHISA6/CTNNA2/NLGN1/PTPRO/ZDHHC15/GRID2/VPS35/ROBO2/PTN/GRIN2B/EPHA4/SIPA1L1/DAB2IP/SLITRK3/PPFIA2/PPP1R9A/AMIGO2/ZNF804A/SLITRK6/CHMP2B/LRFN5/SLIT1/DGKB/LRFN2/HOMER1/NTN1/EPHB1/RELN/GAP43/IL1RAP/FYN/TIAM1/SYBU/SLITRK4/YWHAZ/NTRK2/LRRTM3/CDH2/GPC4/APP/LHFPL4/CDH8 GO:2000146$negative regulation of cell motility52/1712 259/15756 647135/23380/56940/5795/54328/80031/4204/84978/23671/23143/23236/114882/5797/1652/2309/10718/10370/1602/5764/23213/8428/153090/196528/9863/5912/57826/5911/6091/11221/55435/5801/2066/10371/161742/5796/3146/130399/7026/11122/51466/5793/5217/388/753/3488/10891/397/22998/5592/5607/50859/9901HSRGAP2B/SRGAP2/DUSP22/PTPRJ/GPR173/SEMA6D/MECP2/FRMD5/TMEFF2/LRCH1/PLCB1/OSBPL8/PTPRM/DDT/FOXO3/NRG3/CITED2/DACH1/PTN/SULF1/STK24/DAB2IP/ARID2/MAGI2/RAP2B/RAP2C/RAP2A/ROBO1/DUSP10/AP1AR/PTPRR/ERBB4/SEMA3A/SPRED1/PTPRK/HMGB1/ACVR1C/NR2F2/PTPRT/EVL/PTPRG/PFN2/RHOB/LDLRAD4/IGFBP5/PPARGC1A/ARHGDIB/LIMCH1/PRKG1/MAP2K5/SPOCK3/SRGAP3 GO:0050911Fdetection of chemical stimulus involved in sensory perception of smell68/1712 369/1575679501/81061/81399/390538/283694/440153/79334/441669/441670/390429/401427/26682/391211/343563/390431/127068/127069/127077/401993/441308/403244/401994/403239/343173/401992/283093/346528/283092/79544/81328/219464/390649/390167/119749/79317/390168/219437/219438/403253/81327/219432/26338/390142/338675/390154/390144/390155/81309/219431/390648/219436/390151/219428/219429/81318/219469/81168/26696/219493/219484/282770/81300/219487/338674/390181/219447/390113/120586OR4F5/OR11H1/OR4F16/OR4M2/OR4N4/OR11H12/OR11H2/OR4Q3/OR4M1/OR4N2/OR2A7/OR4F4/OR2G6/OR2T29/OR4K2/OR2T34/OR2T10/OR2T11/OR2T5/OR4F21/OR2T35/OR14I1/OR2T27/OR2T3/OR2T2/OR4C12/OR2A1/OR4C13/OR4K1/OR4A15/OR5T2/OR4F15/OR5M10/OR4C46/OR4K5/OR5M1/OR5L1/OR5D18/OR4A47/OR4A16/OR4C6/OR5L2/OR5D13/OR5AP2/OR5T3/OR5D16/OR5T1/OR4C15/OR4S2/OR4F6/OR5D14/OR8H2/OR4C16/OR4C11/OR4A5/OR8H1/OR8J3/OR2T1/OR5AR1/OR5M8/OR10AG1/OR4P4/OR5M11/OR5F1/OR5AK2/OR5AS1/OR4X1/OR8I2 GO:00987429cell-cell adhesion via plasma-membrane adhesion molecules 233/15756 7216/65125/10178/65217/57689/5797/5175/83872/22871/2895/214/6092/84966/54549/137970/57863/8832/22865/27328/57451/1016/6091/57453/1008/347902/284021/1826/90/1010/222256/27253/145581/9071/23705/11122/1600/1525/3556/28316/28513/1007/5607/1002/1000/2239/1012/23562/1006$TRO/WNK1/TENM1/PCDH15/LRRC4C/PTPRM/PECAM1/HMCN1/NLGN1/GRID2/ALCAM/ROBO2/IGSF21/SDK2/UNC5D/CADM3/CD84/SLITRK3/PCDH11X/TENM2/CDH18/ROBO1/DSCAML1/CDH10/AMIGO2/MILR1/DSCAM/ACVR1/CDH12/CDHR3/PCDH17/LRFN5/CLDN10/CADM1/PTPRT/DAB1/CXADR/IL1RAP/CDH20/CDH19/CDH9/MAP2K5/CDH4/CDH2/GPC4/CDH13/CLDN14/CDH8 GO:0007409 axonogenesis 471/157564853/7224/7852/4983/80031/5063/5747/4825/4168/55816/2674/4133/57689/5797/23114/1496/7143/4929/4009/7504/140578/658/5800/214/6092/30011/5803/65078/2043/26037/137970/56288/22865/2549/53358/6091/885/107/57453/288/3800/23242/84189/6474/1826/4684/26053/10371/9355/5781/2042/6585/51466/6586/9423/2047/5649/1947/1600/220164/2596/2534/7074/10818/5076/64919/55740/285220/9723/8633/8399/2675/10090/139065/8013/4915/6683/1002/1749/1000/351/7101NOTCH2/TRPC5/CXCR4/OPHN1/SEMA6D/PAK3/PTK2/NKX6-1/MCF2/DOK5/GFRA1/MAP2/LRRC4C/PTPRM/NFASC/CTNNA2/TNR/NR4A2/LMX1A/XK/CHODL/BMPR1B/PTPRO/ALCAM/ROBO2/SH3KBP1/PTPRZ1/RTN4R/EPHA4/SIPA1L1/UNC5D/PARD3/SLITRK3/GAB1/SHC3/ROBO1/CCK/ADCY1/DSCAML1/ANK3/KIF5C/COBL/SLITRK6/SHOX2/DSCAM/NCAM1/AUTS2/SEMA3A/LHX2/PTPN11/EPHA3/SLIT1/EVL/SLIT3/NTN1/EPHB1/RELN/EFNB1/DAB1/DOK6/GAP43/FYN/TIAM1/FRS2/PAX2/BCL11B/ENAH/EPHA6/SEMA3E/UNC5C/PLA2G10/GFRA2/UST/SLITRK4/NR4A3/NTRK2/SPAST/CDH4/DLX5/CDH2/APP/NR2E1 GO:2000310$regulation of NMDA receptor activity14/171236/15756G5923/1612/22871/2904/3458/57554/8787/2903/2893/5649/1739/10891/2892/351TRASGRF1/DAPK1/NLGN1/GRIN2B/IFNG/LRRC7/RGS9/GRIN2A/GRIA4/RELN/DLG1/PPARGC1A/GRIA3/APP GO:0040013!negative regulation of locomotion56/1712 291/157565647135/23380/56940/5795/54328/80031/4204/84978/23671/23143/23236/114882/5797/1652/2309/10718/10370/5800/1602/6092/5764/23213/8428/153090/196528/9863/5912/57826/5911/6091/11221/55435/5801/2066/57561/10371/161742/5796/3146/130399/7026/11122/51466/5793/5217/388/753/3488/10891/397/22998/9723/5592/5607/50859/9901bSRGAP2B/SRGAP2/DUSP22/PTPRJ/GPR173/SEMA6D/MECP2/FRMD5/TMEFF2/LRCH1/PLCB1/OSBPL8/PTPRM/DDT/FOXO3/NRG3/CITED2/PT< PRO/DACH1/ROBO2/PTN/SULF1/STK24/DAB2IP/ARID2/MAGI2/RAP2B/RAP2C/RAP2A/ROBO1/DUSP10/AP1AR/PTPRR/ERBB4/ARRDC3/SEMA3A/SPRED1/PTPRK/HMGB1/ACVR1C/NR2F2/PTPRT/EVL/PTPRG/PFN2/RHOB/LDLRAD4/IGFBP5/PPARGC1A/ARHGDIB/LIMCH1/SEMA3E/PRKG1/MAP2K5/SPOCK3/SRGAP3 GO:0071805%potassium ion transmembrane transport42/1712 203/15756283652/6557/150160/65267/65125/144245/196527/84679/3773/3760/56479/90134/6616/348980/81831/284525/3768/3763/3751/288/3779/343450/9472/6507/54800/776/126755/1804/3759/3736/23327/1739/57628/11060/56659/23704/3737/51305/3738/283518/3776/3739SLC24A5/SLC12A1/CCT8L2/WNK3/WNK1/ALG10B/ANO6/SLC9A7/KCNJ16/KCNJ3/KCNQ5/KCNH7/SNAP25/HCN1/NETO2/SLC9C2/KCNJ12/KCNJ6/KCND2/ANK3/KCNMB1/KCNT2/AKAP6/SLC1A3/KLHL24/CACNA1D/LRRC38/DPP6/KCNJ2/KCNA1/NEDD4L/DLG1/DPP10/WWP2/KCNK13/KCNE4/KCNA2/KCNK9/KCNA3/KCNRG/KCNK2/KCNA4 GO:0006813potassium ion transport45/1712 227/157564905/283652/6557/150160/65267/65125/144245/196527/84679/3773/3760/56479/90134/6616/348980/81831/284525/3768/116/3763/3751/288/3779/343450/9472/6507/54800/776/126755/1804/2702/3759/3736/23327/1739/57628/11060/56659/23704/3737/51305/3738/283518/3776/3739NSF/SLC24A5/SLC12A1/CCT8L2/WNK3/WNK1/ALG10B/ANO6/SLC9A7/KCNJ16/KCNJ3/KCNQ5/KCNH7/SNAP25/HCN1/NETO2/SLC9C2/KCNJ12/ADCYAP1/KCNJ6/KCND2/ANK3/KCNMB1/KCNT2/AKAP6/SLC1A3/KLHL24/CACNA1D/LRRC38/DPP6/GJA5/KCNJ2/KCNA1/NEDD4L/DLG1/DPP10/WWP2/KCNK13/KCNE4/KCNA2/KCNK9/KCNA3/KCNRG/KCNK2/KCNA4 GO:0008038neuron recognition16/171250/15756R7852/50863/4978/6092/2043/6091/26047/57453/4685/1826/10371/2042/2596/1268/7534/351_CXCR4/NTM/OPCML/ROBO2/EPHA4/ROBO1/CNTNAP2/DSCAML1/NCAM2/DSCAM/SEMA3A/EPHA3/GAP43/CNR1/YWHAZ/APP GO:0035249$synaptic transmission, glutamatergic24/171294/15756~4983/2915/6857/7143/2898/22871/2895/27091/2899/116/53358/22941/59284/2913/2917/1956/9456/5649/4887/10369/594857/1268/1000/1006OPHN1/GRM5/SYT1/TNR/GRIK2/NLGN1/GRID2/CACNG5/GRIK3/ADCYAP1/SHC3/SHANK2/CACNG7/GRM3/GRM7/EGFR/HOMER1/RELN/NPY2R/CACNG2/NPS/CNR1/CDH2/CDH8 GO:0043087regulation of GTPase activity77/1712 455/15756377630/119016/642517/10156/100271927/23380/414189/729873/414060/729540/89839/2245/254272/4983/414059/9910/65125/9754/23143/5747/1793/23236/10788/23677/5910/9628/5923/23348/55854/83478/80243/23092/26575/7984/9779/65078/2043/26037/153090/116/8490/8787/4739/1983/9448/9712/57706/400966/5962/22821/80005/2042/8502/163486/2889/10982/10451/9693/9515/9922/7074/216/397/9462/2475/55843/116987/6102/2776/9824/5592/57569/79658/4915/60682/1901/9901USP17L2/AGAP4/AGAP9/RASA4/RASA4B/SRGAP2/AGAP6/TBC1D3/TBC1D3C/RGPD6/ARHGAP11B/FGD1/TBC1D28/OPHN1/TBC1D3B/RABGAP1L/WNK1/STARD8/LRCH1/PTK2/DOCK1/PLCB1/IQGAP2/SH3BP4/RAP1GDS1/RGS6/RASGRF1/DOCK9/ZC3H15/ARHGAP24/PREX2/ARHGAP26/RGS17/ARHGEF5/TBC1D5/RTN4R/EPHA4/SIPA1L1/DAB2IP/ADCYAP1/RGS5/RGS9/NEDD9/EIF5/MAP4K4/USP6NL/DENND1A/RGPD1/RDX/RASA3/DOCK5/EPHA3/PKP4/DENND1B/RAPGEF1/MAPRE2/VAV3/RAPGEF2/STXBP5L/IQSEC1/TIAM1/ALDH1A1/ARHGDIB/RASAL2/MTOR/ARHGAP15/AGAP1/RP2/GNAQ/ARHGAP11A/PRKG1/ARHGAP20/ARHGAP10/NTRK2/SMAP1/S1PR1/SRGAP3DOWNADULT  RRA GO:0050907=detection of chemical stimulus involved in sensory perception219/2221 419/15697401994/391211/127069/127077/403239/343563/127068/403244/219960/219959/219958/219957/347468/391194/127062/26245/127059/391196/127064/391195/403273/128360/390321/283365/390323/282770/219447/338674/10798/390148/219482/219484/390162/219479/143496/338675/219493/390168/81466/127385/441608/390439/390081/390078/390079/390077/81327/254786/390167/219487/256144/403257/256148/254783/392376/138799/138882/346528/120065/391107/26341/403277/390066/122748/403274/338751/390083/390084/121364/390190/26740/26219/138883/391109/343406/283189/284383/120066/283159/390191/286362/390113/79473/403282/130075/5726/390195/8387/254973/341568/119694/119692/341418/283297/119764/26476/341416/403284/79310/390327/79295/403278/390326/391191/126541/50838/120796/120793/196335/283160/390649/343169/390054/120776/26686/219954/138802/26339/441308/259292/341276/219981/119695/26494/441932/441911/138805/259289/5304/390181/219982/347168/401665/50833/26534/50839/23538/119765/392392/392390/392391/119682/259294/259295/259290/259296/390072/390075/387748/390648/120775/284532/219952/219956/26188/138803/138804/353164/346517/391112/26648/162998/26533/81472/50840/119678/119679/119774/391189/390442/284521/391190/8392/343172/343171/219968/26539/81392/340980/8390/259293/401667/390063/390064/390059/390061/284433/1470/54429/144124/282763/135924/283111/401666/390271/79290/125963/390882/119749/441933/81470/81469/390036/119687/79324/81282/283162/128367/128368/128366/26595/256892/219875/219874/390058/441639/26658/50832/219983OR14I1/OR2G6/OR2T10/OR2T11/OR2T27/OR2T29/OR2T34/OR2T35/OR10Q1/OR1S1/OR1S2/OR9Q2/OR13H1/OR2M2/OR2M3/OR2M4/OR2M5/OR2M7/OR2T12/OR2T33/OR5H14/OR10T2/OR6C1/OR6C6/OR6C75/OR10AG1/OR5AS1/OR5F1/OR5I1/OR5W2/OR5M3/OR5M8/OR5M9/OR5R1/OR52B4/OR5AP2/OR5AR1/OR5M1/OR2L5/OR10J5/OR5B3/OR11G2/OR52E4/OR52E6/OR52E8/OR52N2/OR4A16/OR6C3/OR5M10/OR5M11/OR4C3/OR4C45/OR4S1/OR6C74/OR13C2/OR13C5/OR1N2/OR2A1/OR5P2/OR10K2/OR5H1/OR5K3/OR52D1/OR11H6/OR5H15/OR52L1/OR56A3/OR56A5/OR10A7/OR5B2/OR1J2/OR1J4/OR1N1/OR10K1/OR10R2/OR9G4/OR2Z1/OR5P3/OR8D1/OR5B12/OR13C9/OR4X1/OR52N1/OR6C65/OR9A4/TAS2R38/OR5AN1/OR1E1/OR1L4/OR8S1/OR51F2/OR51S1/OR6C4/OR10A4/OR4X2/OR10J1/OR6C2/OR6C68/OR5H2/OR6C70/OR5H6/OR5K4/OR6C76/OR2AK2/OR10H4/TAS2R13/OR56A1/OR56A4/OR56B4/OR8D2/OR4F15/OR6F1/OR52A5/OR2D2/OR4E2/OR9I1/OR13C8/OR5K1/OR4F21/TAS2R46/OR10A2/OR5A2/OR52R1/OR8G1/OR2W5/OR10J3/OR13F1/TAS2R43/PIP/OR5AK2/OR5A1/OR1J1/OR51T1/TAS2R16/OR10G2/TAS2R10/OR52A1/OR4B1/OR1K1/OR1L6/OR5C1/OR51L1/TAS2R19/TAS2R20/TAS2R31/TAS2R50/OR52N4/OR52N5/OR56B1/OR4F6/OR2D3/OR14A16/OR6Q1/OR9Q1/OR1C1/OR13C3/OR13C4/TAS2R42/OR6V1/OR6Y1/OR7E24/OR7D2/OR10G3/OR2C3/TAS2R14/OR52E2/OR52J3/OR52K2/OR11L1/OR11H4/OR2L13/OR2L8/OR3A3/OR2T8/OR2W3/OR5B21/OR10H1/OR2AE1/OR52B6/OR1G1/TAS2R30/OR51A2/OR51I1/OR51I2/OR51M1/OR51Q1/OR10H5/CST2/TAS2R5/OR10A5/OR51B5/OR9A2/OR51V1/OR51A4/OR8B3/OR13A1/OR1M1/OR7G2/OR4C46/OR13G1/OR2G2/OR2G3/OR52K1/OR51A7/OR51G1/OR51G2/OR8B4/OR10X1/OR10Z1/OR6P1/OR8B2/OR51F1/OR4D5/OR6T1/OR51B6/OR9K2/OR7C2/TAS2R4/OR4D6 GO:0009593detection of chemical stimulus223/2221 454/15697401994/391211/127069/127077/403239/343563/127068/403244/219960/219959/219958/219957/347468/391194/127062/26245/127059/391196/127064/391195/403273/128360/390321/283365/390323/282770/219447/338674/10798/390148/219482/219484/390162/219479/143496/338675/219493/390168/81466/127385/441608/390439/390081/390078/390079/390077/81327/254786/390167/219487/256144/403257/256148/254783/392376/138799/138882/346528/120065/391107/26341/403277/390066/122748/403274/338751/390083/390084/121364/390190/26740/26219/138883/391109/343406/283189/284383/120066/283159/390191/286362/390113/79473/403282/130075/5726/390195/8387/254973/341568/119694/119692/341418/283297/119764/26476/341416/403284/79310/390327/79295/403278/390326/391191/126541/50838/120796/120793/196335/283160/390649/343169/390054/51167/120776/26686/219954/138802/26339/441308/259292/341276/219981/119695/26494/441932/441911/138805/259289/5304/390181/219982/347168/401665/50833/26534/50839/23538/119765/392392/392390/392391/10941/119682/259294/259295/259290/259296/390072/390075/387748/390648/120775/284532/219952/219956/26188/138803/138804/353164/346517/391112/26648/162998/26533/81472/50840/119678/119679/119774/391189/390442/284521/391190/8392/343172/343171/219968/26539/81392/340980/8390/259293/401667/390063/390064/390059/390061/284433/6857/1470/54429/144124/282763/135924/283111/401666/390271/79290/125963/390882/119749/441933/81470/81469/390036/119687/79324/81282/283162/128367/128368/128366/26595/27345/256892/219875/219874/390058/441639/26658/50832/219983OR14I1/OR2G6/OR2T10/OR2T11/OR2T27/OR2T29/OR2T34/OR2T35/OR10Q1/OR1S1/OR1S2/OR9Q2/OR13H1/OR2M2/OR2M3/OR2M4/OR2M5/OR2M7/OR2T12/OR2T33/OR5H14/OR10T2/OR6C1/OR6C6/OR6C75/OR10AG1/OR5AS1/OR5F1/OR5I1/OR5W2/OR5M3/OR5M8/OR5M9/OR5R1/OR52B4/OR5AP2/OR5AR1/OR5M1/OR2L5/OR10J5/OR5B3/OR11G2/OR52E4/OR52E6/OR52E8/OR52N2/OR4A16/OR6C3/OR5M10/OR5M11/OR4C3/OR4C45/OR4S1/OR6C74/OR13C2/OR13C5/OR1N2/OR2A1/OR5P2/OR10K2/OR5H1/OR5K3/OR52D1/OR11H6/OR5H15/OR52L1/OR56A3/OR56A5/OR10A7/OR5B2/OR1J2/OR1J4/OR1N1/OR10K1/OR10R2/OR9G4/OR2Z1/OR5P3/OR8D1/OR5B12/OR13C9/OR< 4X1/OR52N1/OR6C65/OR9A4/TAS2R38/OR5AN1/OR1E1/OR1L4/OR8S1/OR51F2/OR51S1/OR6C4/OR10A4/OR4X2/OR10J1/OR6C2/OR6C68/OR5H2/OR6C70/OR5H6/OR5K4/OR6C76/OR2AK2/OR10H4/TAS2R13/OR56A1/OR56A4/OR56B4/OR8D2/OR4F15/OR6F1/OR52A5/CYB5R4/OR2D2/OR4E2/OR9I1/OR13C8/OR5K1/OR4F21/TAS2R46/OR10A2/OR5A2/OR52R1/OR8G1/OR2W5/OR10J3/OR13F1/TAS2R43/PIP/OR5AK2/OR5A1/OR1J1/OR51T1/TAS2R16/OR10G2/TAS2R10/OR52A1/OR4B1/OR1K1/OR1L6/OR5C1/UGT2A1/OR51L1/TAS2R19/TAS2R20/TAS2R31/TAS2R50/OR52N4/OR52N5/OR56B1/OR4F6/OR2D3/OR14A16/OR6Q1/OR9Q1/OR1C1/OR13C3/OR13C4/TAS2R42/OR6V1/OR6Y1/OR7E24/OR7D2/OR10G3/OR2C3/TAS2R14/OR52E2/OR52J3/OR52K2/OR11L1/OR11H4/OR2L13/OR2L8/OR3A3/OR2T8/OR2W3/OR5B21/OR10H1/OR2AE1/OR52B6/OR1G1/TAS2R30/OR51A2/OR51I1/OR51I2/OR51M1/OR51Q1/OR10H5/SYT1/CST2/TAS2R5/OR10A5/OR51B5/OR9A2/OR51V1/OR51A4/OR8B3/OR13A1/OR1M1/OR7G2/OR4C46/OR13G1/OR2G2/OR2G3/OR52K1/OR51A7/OR51G1/OR51G2/OR8B4/OR10X1/OR10Z1/OR6P1/OR8B2/KCNMB4/OR51F1/OR4D5/OR6T1/OR51B6/OR9K2/OR7C2/TAS2R4/OR4D6205/2221 396/15697t401994/391211/127069/127077/403239/343563/127068/403244/219960/219959/219958/219957/347468/391194/127062/26245/127059/391196/127064/391195/403273/128360/390321/283365/390323/282770/219447/338674/10798/390148/219482/219484/390162/219479/143496/338675/219493/390168/81466/127385/441608/390439/390081/390078/390079/390077/81327/254786/390167/219487/256144/403257/256148/254783/392376/138799/138882/341359/346528/120065/391107/26341/403277/390066/122748/403274/338751/390083/390084/121364/390190/26740/26219/138883/391109/343406/283189/284383/120066/283159/390191/286362/390113/79473/403282/130075/390195/8387/254973/341568/119694/119692/341418/283297/119764/26476/341416/403284/79310/390327/79295/403278/390326/391191/126541/120796/120793/196335/283160/390649/343169/390054/120776/26686/219954/138802/26339/441308/341276/219981/119695/26494/441932/441911/138805/390181/219982/347168/401665/26534/23538/119765/392392/392390/392391/10941/119682/390072/390075/387748/390648/120775/284532/219952/219956/26188/138803/138804/346517/391112/26648/162998/26533/81472/119678/119679/119774/391189/390442/284521/391190/8392/343172/343171/219968/26539/81392/340980/8390/401667/390063/390064/390059/390061/284433/144124/282763/135924/283111/401666/390271/79290/125963/390882/119749/441933/81470/81469/390036/119687/79324/81282/283162/128367/128368/128366/26595/256892/219875/219874/390058/441639/26658/2774/219983>OR14I1/OR2G6/OR2T10/OR2T11/OR2T27/OR2T29/OR2T34/OR2T35/OR10Q1/OR1S1/OR1S2/OR9Q2/OR13H1/OR2M2/OR2M3/OR2M4/OR2M5/OR2M7/OR2T12/OR2T33/OR5H14/OR10T2/OR6C1/OR6C6/OR6C75/OR10AG1/OR5AS1/OR5F1/OR5I1/OR5W2/OR5M3/OR5M8/OR5M9/OR5R1/OR52B4/OR5AP2/OR5AR1/OR5M1/OR2L5/OR10J5/OR5B3/OR11G2/OR52E4/OR52E6/OR52E8/OR52N2/OR4A16/OR6C3/OR5M10/OR5M11/OR4C3/OR4C45/OR4S1/OR6C74/OR13C2/OR13C5/OR1N2/SYT10/OR2A1/OR5P2/OR10K2/OR5H1/OR5K3/OR52D1/OR11H6/OR5H15/OR52L1/OR56A3/OR56A5/OR10A7/OR5B2/OR1J2/OR1J4/OR1N1/OR10K1/OR10R2/OR9G4/OR2Z1/OR5P3/OR8D1/OR5B12/OR13C9/OR4X1/OR52N1/OR6C65/OR9A4/OR5AN1/OR1E1/OR1L4/OR8S1/OR51F2/OR51S1/OR6C4/OR10A4/OR4X2/OR10J1/OR6C2/OR6C68/OR5H2/OR6C70/OR5H6/OR5K4/OR6C76/OR2AK2/OR10H4/OR56A1/OR56A4/OR56B4/OR8D2/OR4F15/OR6F1/OR52A5/OR2D2/OR4E2/OR9I1/OR13C8/OR5K1/OR4F21/OR10A2/OR5A2/OR52R1/OR8G1/OR2W5/OR10J3/OR13F1/OR5AK2/OR5A1/OR1J1/OR51T1/OR10G2/OR52A1/OR4B1/OR1K1/OR1L6/OR5C1/UGT2A1/OR51L1/OR52N4/OR52N5/OR56B1/OR4F6/OR2D3/OR14A16/OR6Q1/OR9Q1/OR1C1/OR13C3/OR13C4/OR6V1/OR6Y1/OR7E24/OR7D2/OR10G3/OR2C3/OR52E2/OR52J3/OR52K2/OR11L1/OR11H4/OR2L13/OR2L8/OR3A3/OR2T8/OR2W3/OR5B21/OR10H1/OR2AE1/OR52B6/OR1G1/OR51A2/OR51I1/OR51I2/OR51M1/OR51Q1/OR10H5/OR10A5/OR51B5/OR9A2/OR51V1/OR51A4/OR8B3/OR13A1/OR1M1/OR7G2/OR4C46/OR13G1/OR2G2/OR2G3/OR52K1/OR51A7/OR51G1/OR51G2/OR8B4/OR10X1/OR10Z1/OR6P1/OR8B2/OR51F1/OR4D5/OR6T1/OR51B6/OR9K2/OR7C2/GNAL/OR4D6 GO:0031424keratinization76/2221 222/15697100288323/337975/337979/337966/337967/353139/337968/26239/353140/353141/353142/199834/353132/353133/353134/353135/353137/337976/85285/85291/85290/84616/728318/337977/337978/337879/353143/353144/84648/353145/353131/448835/337974/388697/6698/6707/6701/337973/337880/6700/2312/6704/6699/6703/3713/386675/163778/6705/26154/85289/337971/337972/337970/56603/386674/83899/11005/386680/51535/653240/81871/728224/100132386/337882/337969/337960/284827/254950/386672/83900/85280/100507608/100505724/83901/81870/386681fKRTAP21-3/KRTAP20-1/KRTAP22-1/KRTAP6-1/KRTAP6-2/LCE2A/KRTAP6-3/LCE2B/LCE2C/LCE2D/LCE3A/LCE4A/LCE1B/LCE1C/LCE1D/LCE1E/LCE1F/KRTAP20-2/KRTAP4-1/KRTAP4-2/KRTAP4-3/KRTAP4-4/KRTAP9-1/KRTAP21-1/KRTAP21-2/KRTAP8-1/LCE3B/LCE3C/LCE3D/LCE3E/LCE1A/LCE6A/KRTAP19-7/HRNR/SPRR1A/SPRR3/SPRR2B/KRTAP19-6/KRTAP11-1/SPRR2A/FLG/SPRR2E/SPRR1B/SPRR2D/IVL/KRTAP10-7/SPRR4/SPRR2F/ABCA12/KRTAP4-5/KRTAP19-4/KRTAP19-5/KRTAP19-3/CYP26B1/KRTAP10-6/KRTAP9-2/SPINK5/KRTAP10-5/PPHLN1/KRTAP4-11/KRTAP4-6/KRTAP4-8/KRTAP4-9/KRTAP19-1/KRTAP19-2/KRTAP13-3/KRTAP13-4/KRTAP15-1/KRTAP10-4/KRTAP9-3/KRTAP9-4/KRTAP9-6/KRTAP9-7/KRTAP9-8/KRTAP9-9/KRTAP10-8 GO:0018149peptide cross-linking30/222160/15697100129271/353139/26239/353140/353141/353142/199834/353132/353133/353134/353135/353137/353143/353144/84648/353145/353131/6698/6707/6701/6700/2312/6704/6699/6703/3713/50859/163778/6705/7737C1orf68/LCE2A/LCE2B/LCE2C/LCE2D/LCE3A/LCE4A/LCE1B/LCE1C/LCE1D/LCE1E/LCE1F/LCE3B/LCE3C/LCE3D/LCE3E/LCE1A/SPRR1A/SPRR3/SPRR2B/SPRR2A/FLG/SPRR2E/SPRR1B/SPRR2D/IVL/SPOCK3/SPRR4/SPRR2F/RNF113A GO:0043588skin development93/2221 410/15697]100288323/337975/337979/337966/100129271/337967/353139/337968/26239/353140/353141/353142/199834/353132/353133/353134/353135/353137/337976/85285/85291/85290/84616/728318/337977/337978/337879/353143/353144/84648/353145/353131/448835/5068/337974/388697/6698/6707/6701/337973/337880/6700/2312/6093/6704/6699/6703/3713/8626/4763/2252/386675/163778/6705/57216/26154/85289/337971/337972/337970/56603/386674/121549/83899/11005/386680/5469/5275/2255/538/51535/653240/81871/728224/100132386/337882/337969/151516/337960/284827/254950/130120/386672/83900/85280/100507608/100505724/83901/81870/92344/386681/2069/388698KRTAP21-3/KRTAP20-1/KRTAP22-1/KRTAP6-1/C1orf68/KRTAP6-2/LCE2A/KRTAP6-3/LCE2B/LCE2C/LCE2D/LCE3A/LCE4A/LCE1B/LCE1C/LCE1D/LCE1E/LCE1F/KRTAP20-2/KRTAP4-1/KRTAP4-2/KRTAP4-3/KRTAP4-4/KRTAP9-1/KRTAP21-1/KRTAP21-2/KRTAP8-1/LCE3B/LCE3C/LCE3D/LCE3E/LCE1A/LCE6A/REG3A/KRTAP19-7/HRNR/SPRR1A/SPRR3/SPRR2B/KRTAP19-6/KRTAP11-1/SPRR2A/FLG/ROCK1/SPRR2E/SPRR1B/SPRR2D/IVL/TP63/NF1/FGF7/KRTAP10-7/SPRR4/SPRR2F/VANGL2/ABCA12/KRTAP4-5/KRTAP19-4/KRTAP19-5/KRTAP19-3/CYP26B1/KRTAP10-6/ASCL4/KRTAP9-2/SPINK5/KRTAP10-5/MED1/SERPINB13/FGF10/ATP7A/PPHLN1/KRTAP4-11/KRTAP4-6/KRTAP4-8/KRTAP4-9/KRTAP19-1/KRTAP19-2/ASPRV1/KRTAP13-3/KRTAP13-4/KRTAP15-1/REG3G/KRTAP10-4/KRTAP9-3/KRTAP9-4/KRTAP9-6/KRTAP9-7/KRTAP9-8/KRTAP9-9/GORAB/KRTAP10-8/EREG/FLG2 GO:0008544epidermis development99/2221 451/15697{100288323/337975/337979/337966/100129271/337967/353139/337968/26239/353140/353141/353142/199834/353132/353133/353134/353135/353137/337976/85285/85291/85290/84616/728318/337977/337978/337879/60401/353143/353144/84648/353145/353131/448835/5068/337974/388697/6698/6707/6701/337973/337880/6700/2312/6093/6704/6699/6703/3713/8626/4763/2252/84189/386675/163778/5459/6705/57216/26154/7454/85289/337971/337972/337970/56603/386674/83899/11005/386680/10427/5469/5275/2255/7399/538/51535/653240/81871/728224/100132386/337882/337969/337960/284827/254950/645027/130120/386672/412/83900/85280/100507608/100505724/83901/81870/92344/386681/2069/388698KRTAP21-3/KRTAP20-1/KRTAP22-1/KRTAP6-1/C1orf68/KRTAP6-2/LCE2A/KRTAP6-3/LCE2B/LCE2C/LCE2D/LCE3A/LCE4A/LCE1B/LCE1C/LCE1D/LCE1E/LCE1F/KRTAP20-2/KRTAP4-1/KRTAP4-2/KRTAP4-3/KRTAP4-4/KRTAP9-1/KRTAP21-1/KRTAP21-2/KRTAP8-1/EDA2R/LCE3B/LCE3C/LCE3D/LCE3E/LCE1A/LCE6A/REG3A/KRTAP19-7/HRNR/SPRR1A/SPRR3/SPRR2B/KRTAP19-6/KRTAP11-1/SPRR2A/FLG/ROCK1/SPRR2E/SPRR1B/SPRR2D/IVL/TP63/NF1/FGF7/SLITRK6/KRTAP10-7/SPRR4/POU4F3/SPRR2F/VANGL2/ABCA12/WAS/KRTAP4-5/KRTAP19-4/KRTAP19-5/KRTAP19-3/CYP26B1/KRTAP10-6/KRTAP9-2/SPINK5/KRTAP10-5/SEC24B/MED1/SERPINB13/FGF10/USH2A/ATP7A/PPHLN1/KRTAP4-11/KRTAP4-6/KRTAP4-8/KRTAP4-9/KRTAP19-1/KRTAP19-2/KRTAP13-3/KRTAP13-4/KRTAP15-1/EVPLL/REG3G/KRTAP10-4/STS/KRTAP9-3/KRTAP9-4/KRTAP9-6/KRTAP9-7/KRTAP9-8/KRTAP9-9/GORAB/KRTAP10-8/EREG/FLG2 GO:0099560synaptic membrane adhesion12/2221< 26/15697E5789/1007/114798/57689/145581/84631/22871/27253/2239/22865/22854/9378MPTPRD/CDH9/SLITRK1/LRRC4C/LRFN5/SLITRK2/NLGN1/PCDH17/GPC4/SLITRK3/NTNG1/NRXN1 UPADULT  RRA(No significant enrichments)YOUNGAGE  RRA163/4070 371/15697.OR10J3/OR6K6/OR6N1/OR6N2/OR4B1/OR4F15/OR4F6/OR10K1/OR10K2/OR10R2/OR10T2/OR10X1/OR6P1/OR6Y1/OR5AC2/OR6C4/OR6C1/OR6C3/OR6C6/OR10AG1/OR5AS1/OR5F1/OR5I1/OR5W2/OR9A4/OR5H2/OR5H6/OR5K3/OR5K4/OR4E2/OR5B2/OR13C2/OR13C3/OR13C4/OR13C5/OR13C8/OR13C9/OR5AP2/OR5AR1/OR5M1/OR5M10/OR5M11/OR10J1/OR10J5/OR52E4/OR52E6/OR52E8/OR11H4/OR10S1/OR4D5/OR6T1/OR8D4/OR8B12/OR9I1/OR5B12/OR5B21/OR2C3/OR56B4/OR51F2/OR51S1/OR51T1/OR52R1/OR9G4/OR6V1/OR10A7/OR6C74/OR8D1/OR1N2/OR2AK2/OR52L1/OR56A1/OR56A3/OR56A4/OR56A5/OR8S1/OR6Q1/OR9Q1/OR13G1/OR2G2/OR2G3/OR6F1/OR2A4/OR5A1/OR5A2/OR5AN1/OR8B8/OR51B5/OR52D1/OR10G3/OR1L4/OR51L1/OR51F1/OR1C1/OR1J2/OR1J4/OR1N1/OR10G2/OR51E1/OR51E2/OR51V1/OR52A1/OR52A5/OR5K1/OR9K2/OR2AP1/OR4F21/OR10A3/OR10A6/OR2K2/OR6X1/OR8D2/OR2A14/OR52E2/OR52J3/OR52K1/OR52K2/OR9A2/OR52H1/OR6M1/OR2AE1/OR2AT4/OR11L1/OR14A16/OR2L13/OR2L8/OR2T8/OR2W3/OR1L6/OR51A2/OR51A4/OR10A5/OR10H4/OR2A12/OR2A2/OR2A25/OR1K1/OR2A5/OR6B1/OR5C1/OR1J1/OR5K2/OR51B2/OR51B6/OR8G1/OR51A7/OR51G1/OR51G2/OR8B2/OR8B3/OR8B4/OR2Z1/OR7E24/OR4D6/OR2W5/OR52I1/OR52I2/OR52M1/OR51D1/OR8A1/OR10H1/OR10H3/OR10H5/OR13D1169/4070POR10J3/OR6K6/OR6N1/OR6N2/OR4B1/OR4F15/OR4F6/OR10K1/OR10K2/OR10R2/OR10T2/OR10X1/OR6P1/OR6Y1/OR5AC2/OR6C4/OR6C1/OR6C3/OR6C6/OR10AG1/OR5AS1/OR5F1/OR5I1/OR5W2/OR9A4/OR5H2/OR5H6/OR5K3/OR5K4/OR4E2/OR5B2/OR13C2/OR13C3/OR13C4/OR13C5/OR13C8/OR13C9/OR5AP2/OR5AR1/OR5M1/OR5M10/OR5M11/OR10J1/OR10J5/OR52E4/OR52E6/OR52E8/OR11H4/CNGA2/OR10S1/OR4D5/OR6T1/OR8D4/OR8B12/OR9I1/OR5B12/OR5B21/OR2C3/OR56B4/OR51F2/OR51S1/OR51T1/OR52R1/OR9G4/OR6V1/OR10A7/OR6C74/OR8D1/OR1N2/OR2AK2/OR52L1/OR56A1/OR56A3/OR56A4/OR56A5/OR8S1/OR6Q1/OR9Q1/OR13G1/OR2G2/OR2G3/OR6F1/OR2A4/OR5A1/OR5A2/OR5AN1/OR8B8/OR51B5/OR52D1/OR10G3/OR1L4/OR51L1/OR51F1/OR1C1/OR1J2/OR1J4/OR1N1/OR10G2/OR51E1/OR51E2/OR51V1/OR52A1/OR52A5/OR5K1/OR9K2/OR2AP1/OR4F21/BBS4/OR10A3/OR10A6/OR2K2/OR6X1/OR8D2/OR2A14/OR52E2/OR52J3/OR52K1/OR52K2/OR9A2/NCAM2/OR52H1/OR6M1/OR2AE1/OR2AT4/OR11L1/OR14A16/OR2L13/OR2L8/OR2T8/OR2W3/NAV2/OR1L6/OR51A2/OR51A4/UGT2A1/OR10A5/OR10H4/OR2A12/OR2A2/OR2A25/OR1K1/OR2A5/OR6B1/OR5C1/OR1J1/OR5K2/OR51B2/OR51B6/OR8G1/OR51A7/OR51G1/OR51G2/OR8B2/OR8B3/OR8B4/MKKS/OR2Z1/OR7E24/OR4D6/OR2W5/OR52I1/OR52I2/OR52M1/OR51D1/OR8A1/OR10H1/OR10H3/OR10H5/OR13D1187/4070OR10J3/PIP/OR6K6/OR6N1/OR6N2/OR4B1/OR4F15/OR4F6/OR10K1/OR10K2/OR10R2/OR10T2/OR10X1/OR6P1/OR6Y1/OR5AC2/OR6C4/OR6C1/OR6C3/OR6C6/OR10AG1/OR5AS1/OR5F1/OR5I1/OR5W2/OR9A4/TAS2R38/OR5H2/OR5H6/OR5K3/OR5K4/CASR/SYT1/OR4E2/TAS2R13/TAS2R14/TRPA1/OR5B2/FOXA2/OR13C2/OR13C3/OR13C4/OR13C5/OR13C8/OR13C9/OR5AP2/OR5AR1/OR5M1/OR5M10/OR5M11/OR10J1/OR10J5/OR52E4/OR52E6/OR52E8/OR11H4/OR10S1/OR4D5/OR6T1/OR8D4/OR8B12/OR9I1/TAS2R39/OR5B12/OR5B21/OR2C3/OR56B4/CYB5R4/OR51F2/OR51S1/OR51T1/OR52R1/OR9G4/OR6V1/OR10A7/OR6C74/OR8D1/OR1N2/RYR2/OR2AK2/OR52L1/OR56A1/OR56A3/OR56A4/OR56A5/OR8S1/OR6Q1/OR9Q1/OR13G1/OR2G2/OR2G3/OR6F1/OR2A4/OR5A1/OR5A2/OR5AN1/OR8B8/OR51B5/OR52D1/OR10G3/OR1L4/TAS2R10/OR51L1/OR51F1/OR1C1/OR1J2/OR1J4/OR1N1/OR10G2/OR51E1/OR51E2/OR51V1/OR52A1/OR52A5/OR5K1/OR9K2/OR2AP1/OR4F21/OR10A3/OR10A6/OR2K2/OR6X1/OR8D2/KCNMB4/OR2A14/TAS2R5/OR52E2/OR52J3/TLR4/OR52K1/OR52K2/CST4/OR9A2/OR52H1/NKX6-1/LY96/PKD2L1/TREM2/OR6M1/OR2AE1/OR2AT4/OR11L1/OR14A16/OR2L13/OR2L8/OR2T8/OR2W3/OR1L6/OR51A2/OR51A4/UGT2A1/OR10A5/OR10H4/OR2A12/OR2A2/OR2A25/OR1K1/OR2A5/OR6B1/OR5C1/OR1J1/OR5K2/TAS2R4/OR51B2/OR51B6/OR8G1/OR51A7/OR51G1/OR51G2/OR8B2/OR8B3/OR8B4/OR2Z1/OR7E24/OR4D6/OR2W5/OR52I1/OR52I2/OR52M1/OR51D1/RTP4/OR8A1/OR10H1/OR10H3/OR10H5/TAS2R40/OR13D1 OLDAGE  RRA GO:0010769<regulation of cell morphogenesis involved in differentiation72/2141 294/15697MCF2/ANAPC2/GRIN1/NSMF/SEMA6D/OBSL1/DOCK1/GORASP1/GDI1/PLXNA3/CDK5/IL1RAPL1/CAPRIN2/ARHGAP44/XK/NRP1/POSTN/BHLHB9/MAP6/LRP1/FLNA/L1CAM/AP1AR/EPHB2/NLGN1/SHOX2/NTN1/NEUROG3/TRPC5/LIMS2/DRAXIN/POU3F2/TLX2/RTN4R/BAIAP2/OPA1/RAC3/PLXNA2/KALRN/TRAK2/TUBB2B/ZSWIM6/ZSWIM8/ADNP/ARHGAP4/BRSK2/CXCL12/PLXNA4/WNT7A/FBXO31/SHANK3/HECW2/VEGFA/SEMA3G/ROBO2/SEMA4C/BDNF/MDK/NTRK3/ABI2/UBE3A/MYCBP2/TBR1/PAK3/MARK2/PLXNA1/WNT3/ARC/TNFRSF12A/RAP2A/SS18L1/RNF6GENOMEWIDE  FGSEASet SizeEnrichment ScoreNES GO:0009913epidermal cell differentiation GO:0030216keratinocyte differentiation GO:0070268 cornification GO:0030049muscle filament sliding GO:0033275actin-myosin filament sliding GO:00970060regulation of plasma lipoprotein particle levels GO:00509064detection of stimulus involved in sensory perception GO:0007606'sensory perception of chemical stimulusDOWNADULT  FGSEA GO:0061687$detoxification of inorganic compound GO:0048568embryonic organ development GO:0097501stress response to metal ion GO:0071294cellular response to zinc ion GO:0048704'embryonic skeletal system morphogenesis GO:0048705skeletal system morphogenesis GO:00901501establishment of protein localization to membrane GO:0001501skeletal system development GO:0048706%embryonic skeletal system development GO:0036293#response to decreased oxygen levels GO:0009952(anterior/posterior pattern specification GO:0001666response to hypoxia GO:0007015actin filament organization GO:0030198!extracellular matrix organization GO:0048562embryonic organ morphogenesis GO:0031589cell-substrate adhesion GO:0043062$extracellular structure organization GO:0043691reverse cholesterol transport GO:0001525 angiogenesis GO:0070482response to oxygen levelsUPADULT  FGSEA GO:0060326cell chemotaxis GO:0072503.cellular divalent inorganic cation homeostasisYOUNGAGE  FGSEA GO:0016575histone deacetylation GO:0019080viral gene expression GO:0019083viral transcription GO:0099565chemical synaptic transmission GO:0046782!regulation of viral transcriptionOLDAGE  FGSEA GO:0019731antibacterial humoral response GO:0052548$regulation of endopeptidase activity GO:0061844Gantimicrobial humoral immune response mediated by antimicrobial peptide GO:0080111DNA demethylation GO:0071280cellular response to copper ionGene SetHDAC10SIRT2(Per-SNP Cross-Disease Association MetricSKIANNZ target_HITS mean_backSD_backLOGODDPRKD2 DOWNADULTHDAC7 OLD_ADULTNACC2OUTSIDEMIER2Unchanged DNaseZNHIT1UPADULTZBTB7B YOUNG_ADULTCTBP1ALLRBM14HDAC1Per-SNP phyloP20waysMTA2BRMS1HDAC5AKAP8AKAP8LSIRT7C6orf89PHBSPHK2TGFB1Per-SNP Estimated Allele AgeSIRT6TP53TADA3PER1SREBF1BAZ2APINK1HDAC3SIRT3PER2Per-SNP LINSIGHTMORF4L1HDAC4SIN3BRCOR1UCNADULT-BIASED Region Intersects:ADULT-BIASED  YOUNG-BIASEDADULT-BIASED  OLD-BIASEDFETAL-BIASED Region Intersects:FETAL-BIASED  YOUNG-BIASEDFETAL-BIASED  OLD-BIASEDMean Effect Size  FETALBIASEDSD Effect Size  FETALBIASEDMean Effect Size  ADULTBIASEDSD Effect Size  ADULTBIASEDMean Effect Size  ADULT-BIASEDSD Effect Size  ADULT-BIASEDMean Effect Size  FETAL-BIASEDSD Effect Size  FETAL-BIASEDADULT_BIASED*NOCHANGE-OUTSIDEOUTSIDE-FETAL_BIASED*NOCHANGE+ADULT_BIASED*NOCHANGE-FETAL_BIASED*NOCHANGENOT_AGE_CHANGED-CONTROL%NOT_AGE_CHANGED-FETAL_BIASED*NOCHANGEOUTSIDE-NOT_AGE_CHANGED%ADULT_BIASED*NOCHANGE-NOT_AGE_CHANGEDFETAL_BIASED-CONTROLNOT_AGE_CHANGED-FETAL_BIASED-OLD-BIASED*FETAL_BIASED-FETAL_BIASED*NOCHANGE/YOUNG-BIASED*FETAL_BIASED-FETAL_BIASED*NOCHANGE'OLD-BIASED*FETAL_BIASED-NOT_AGE_CHANGED)YOUNG-BIASED*FETAL_BIASED-NOT_AGE_CHANGEDOUTSIDE-OLD-BIASED*FETAL_BIAS<ED-ADULT_BIASED*NOCHANGE-OLD-BIASED*FETAL_BIASED1YOUNG-BIASED*FETAL_BIASED-OLD-BIASED*FETAL_BIASED!YOUNG-BIASED*FETAL_BIASED-OUTSIDE/YOUNG-BIASED*FETAL_BIASED-ADULT_BIASED*NOCHANGEADULT_BIASED-CONTROLADULT_BIASED-FETAL_BIASEDADULT_BIASED-NOT_AGE_CHANGED-OLD-BIASED*ADULT_BIASED-FETAL_BIASED*NOCHANGE/YOUNG-BIASED*ADULT_BIASED-FETAL_BIASED*NOCHANGE'OLD-BIASED*ADULT_BIASED-NOT_AGE_CHANGED)YOUNG-BIASED*ADULT_BIASED-NOT_AGE_CHANGED/OLD-BIASED*ADULT_BIASED-OLD-BIASED*FETAL_BIASED1YOUNG-BIASED*ADULT_BIASED-OLD-BIASED*FETAL_BIASEDOUTSIDE-OLD-BIASED*ADULT_BIASED-ADULT_BIASED*NOCHANGE-OLD-BIASED*ADULT_BIASED1YOUNG-BIASED*FETAL_BIASED-OLD-BIASED*ADULT_BIASED1YOUNG-BIASED*ADULT_BIASED-OLD-BIASED*ADULT_BIASED!YOUNG-BIASED*ADULT_BIASED-OUTSIDE/YOUNG-BIASED*ADULT_BIASED-ADULT_BIASED*NOCHANGE3YOUNG-BIASED*ADULT_BIASED-YOUNG-BIASED*FETAL_BIASED FETALBIASED-associated Variants: ADULTBIASED-associated Variants: YOUNGBIASED-associated Variants:OLDBIASED-associated Variants:$FETAL_BIASED Region-associated genesFETAL_BIASED Expression genes$ADULT_BIASED Region-associated genesADULT_BIASED Expression genes$YOUNG_BIASED Region-associated genesYOUNG_BIASED Expression genes"OLD_BIASED Region-associated genesOLD_BIASED Expression genes,Supplementary Table 4. Disease Associations.( Describes the results of analyses exploring the effects of changes to nearby epigenetic context (i.e. local accessibility) on the heritable aging-associated disease risk of human genetic variants, at the genome-wide and per-locus level. Sheet 1   UKB Summary Stat Files : Metadata of UK Biobanks summary-statistic datasets used. Sheet 2 -  SNP Enrichments - DNase Regions : Enrichment results comparing the occurrence of significance-thresholded (1e-6) SNPs nearby DNase regions generally, when compared to randomly-generated region sets (see Supplemental Methods). Sheet 3 -  SNP Enrich - Hypergeo  ADULTBIASED : Hypergeometric testing results for nearby significance-thresholded variants using the adult-biased region set. Additional developmental trait GWAS and longevity GWAS testing at bottom of sheet. Sheet 4 -  SNP Enrich - Hypergeo  FETALBIAS : Hypergeometric testing results for nearby significance-thresholded variants using the fetal-biased region set. Additional developmental trait GWAS and longevity GWAS testing at bottom of sheet. Sheet 5 -  SNP Enrich - Hypergeo  YOUNGBIAS : Hypergeometric testing results for nearby significance-thresholded variants using the young-biased region set. Sheet 6 -  SNP Enrich - Hypergeo  OLDBIAS : Hypergeometric testing results for nearby significance-thresholded variants using the old-biased region set. Sheet 7 -  SNP Enrich - Intersects : Hypergeometric testing results for nearby significance-thresholded variants using the indicated developmental/age-altered region intersect sets. Sheet 8   Effect-Size Dists : Wilcoxon testing results for differences in absolute effect size values of variants nearby fetal-biased and adult-biased region sets, per-disease (see Supplemental Methods). Sheet 9 -  Per-SNP Comparisons : Comparisons of indicated metric (e.g. Cross-Disease association metric) across variants nearby the indicated region sets using Tukey post-hoc corrections (see Supplemental Methods). Sheet 10 -  PhastCons Tests + CLINVAR : (Top) Comparing the cross-disease association metric of variants falling within or outside phastCons elements globally, or when constraining by nearby altered-accessibility region sets. (Bottom) Comparing multiple per-variant metrics of ClinVar variants to genome-wide randomly sampled variants (see Supplemental Methods). Sheet 11   Genewise Rank Testing : Comparing the cross-disease rankings (based on disease-associations) of the indicated gene sets compared to randomly-sampled sets of protein-coding genes (see Supplemental Methods). Sheet 12 -  Genewise Rank Agg : Gene-set enrichments for sets of genes defined when aggregating within-disease gene rankings across diseases, when using an RRA-based approach (top), or when using an FGSEA rank-value based approach (bottom) (see Supplemental Methods). Top significant (q-value < 0.05) GO BP enrichments for each analysis are shown. Sheet 13   HDAC Gene Set : Comparing the per-gene behaviour of top genes in the FGSEA-enriched  HDAC term in terms of different metrics, when compared to randomized gene sets.  ANN refers to the use of different region sets (e.g. YOUNG_BIASED) in binning variants prior to assigning per-gene metrics (see Supplemental Methods).  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