Supplementary Table 8. All_vs_DEG.KEGG_classification.					
Classification_level2	Classification_level1	Type	Gene_number	Percentage	Gene
Aging	Organismal Systems	ALL	5	0.59	P08228:Sod1; P15208:Insr; P25799:Nfkb1; P68181:Prkacb; Q61411:Hras
Aging	Organismal Systems	DEG	1	1.28	P68181:Prkacb
Circulatory system	Organismal Systems	ALL	32	3.77	G5E829:Atp2b1; O55143:Atp2a2; P08752:Gnai2; P0DP28:Calm3; P11881:Itpr1; P12787:Cox5a; P17665:Cox7c; P43024:Cox6a1; P48771:Cox7a2; P56391:Cox6b1; P62137:Ppp1ca; P62141:Ppp1cb; P62715:Ppp2cb; P63085:Mapk1; P63094:Gnas; P68181:Prkacb; P70227:Itpr3; P99028:Uqcrh; Q61210:Arhgef1; Q63844:Mapk3; Q6IRU2:Tpm4; Q6PHZ2:Camk2d; Q76MZ3:Ppp2r1a; Q7TNP2:Ppp2r1b; Q8BG95:Ppp1r12b; Q8VDN2:Atp1a1; Q9CPQ1:Cox6c; Q9CQ69:Uqcrq; Q9CR68:Uqcrfs1; Q9D0M3:Cyc1; Q9DB77:Uqcrc2; Q9DBR7:Ppp1r12a
Circulatory system	Organismal Systems	DEG	4	5.13	P62141:Ppp1cb; P68181:Prkacb; Q63844:Mapk3; Q6PHZ2:Camk2d
Development and regeneration	Organismal Systems	ALL	23	2.71	B2RXS4:Plxnb2; O08553:Dpysl2; O54890:Itgb3; O55222:Ilk; P08752:Gnai2; P09055:Itgb1; P15066:Jund; P25799:Nfkb1; P34152:Ptk2; P35235:Ptpn11; P47930:Fosl2; P54763:Ephb2; P60766:Cdc42; P63085:Mapk1; P70206:Plxna1; Q03145:Epha2; Q3THE2:Myl12b; Q61411:Hras; Q63844:Mapk3; Q64337:Sqstm1; Q6PHZ2:Camk2d; Q8CIN4:Pak2; Q99M51:Nck1
Development and regeneration	Organismal Systems	DEG	3	3.85	P60766:Cdc42; Q63844:Mapk3; Q6PHZ2:Camk2d
Digestive system	Organismal Systems	ALL	27	3.18	B2RX12:Abcc3; G5E829:Atp2b1; O08528:Hk2; O08997:Atox1; O55143:Atp2a2; P02463:Col4a1; P05202:Got2; P08752:Gnai2; P09528:Fth1; P0DP28:Calm3; P10852:Slc3a2; P11881:Itpr1; P49282:Slc11a2; P62835:Rap1a; P63094:Gnas; P68181:Prkacb; P70227:Itpr3; Q60930:Vdac2; Q61009:Scarb1; Q64430:Atp7a; Q6PHZ2:Camk2d; Q8BLF1:Nceh1; Q8CFE6:Slc38a2; Q8K0B2:Lmbrd1; Q8VDN2:Atp1a1; Q9DAX2:Plpp2; Q9WV55:Vapa
Digestive system	Organismal Systems	DEG	4	5.13	O08997:Atox1; P68181:Prkacb; Q64430:Atp7a; Q6PHZ2:Camk2d
Endocrine system	Organismal Systems	ALL	65	7.66	A2A6Q5:Cdc27; A2ABV5:Med14; G5E829:Atp2b1; O08528:Hk2; O54890:Itgb3; O55143:Atp2a2; O55222:Ilk; P02463:Col4a1; P08003:Pdia4; P08752:Gnai2; P0DP28:Calm3; P11352:Gpx1; P11881:Itpr1; P12382:Pfkl; P13011:Scd2; P15066:Jund; P15208:Insr; P25799:Nfkb1; P30416:Fkbp4; P31324:Prkar2b; P32020:Scp2; P35235:Ptpn11; P45952:Acadm; P51943:Ccna2; P52480:Pkm; P60766:Cdc42; P62137:Ppp1ca; P62141:Ppp1cb; P63085:Mapk1; P63094:Gnas; P63213:Gng2; P68181:Prkacb; P70227:Itpr3; Q05769:Ptgs2; Q3V300:Kif22; Q5SWU9:Acaca; Q60520:Sin3a; Q60817:Naca; Q61009:Scarb1; Q61210:Arhgef1; Q61411:Hras; Q62074:Prkci; Q62417:Sorbs1; Q63844:Mapk3; Q6P2K6:Ppp4r3a; Q6PHZ2:Camk2d; Q8BG95:Ppp1r12b; Q8BH04:Pck2; Q8BLF1:Nceh1; Q8C129:Lnpep; Q8CJ53:Trip10; Q8K2J0:Plcd3; Q8VDN2:Atp1a1; Q91YP2:Nln; Q921H8:Acaa1a; Q99K74:Med24; Q9CXP8:Gng10; Q9CZW4:Acsl3; Q9D051:Pdhb; Q9D0V7:Ebag9; Q9D7B7:Gpx8; Q9DBC7:Prkar1a; Q9DBR7:Ppp1r12a; Q9R0H0:Acox1; Q9WTX8:Mad1l1
Endocrine system	Organismal Systems	DEG	10	12.82	A2A6Q5:Cdc27; P11352:Gpx1; P51943:Ccna2; P60766:Cdc42; P62141:Ppp1cb; P63213:Gng2; P68181:Prkacb; Q63844:Mapk3; Q6PHZ2:Camk2d; Q9CXP8:Gng10
Environmental adaptation	Organismal Systems	ALL	70	8.24	A2AIL4:Ndufaf6; A2APY7:Ndufaf5; A2BH40:Arid1a; O54941:Smarce1; P08752:Gnai2; P0DP28:Calm3; P11881:Itpr1; P12787:Cox5a; P17665:Cox7c; P43024:Cox6a1; P48771:Cox7a2; P52503:Ndufs6; P56391:Cox6b1; P56480:Atp5f1b; P62878:Rbx1; P63085:Mapk1; P63094:Gnas; P63213:Gng2; P68181:Prkacb; P70227:Itpr3; P97450:Atp5pf; P99028:Uqcrh; Q03265:Atp5f1a; Q3TKT4:Smarca4; Q59J78:Ndufaf2; Q61411:Hras; Q62425:Ndufa4; Q63844:Mapk3; Q6PHZ2:Camk2d; Q6ZQ88:Kdm1a; Q7TMF3:Ndufa12; Q8BGD8:Coa6; Q8BJ03:Cox15; Q8K0C8:Cox19; Q8K2B3:Sdha; Q91VD9:Ndufs1; Q91WD5:Ndufs2; Q921H9:Coa7; Q99JR8:Smarcd2; Q99LC3:Ndufa10; Q99LY9:Ndufs5; Q9CPP6:Ndufa5; Q9CPQ1:Cox6c; Q9CPQ8:Atp5mg; Q9CQ54:Ndufc2; Q9CQ69:Uqcrq; Q9CQ75:Ndufa2; Q9CQ91:Ndufa3; Q9CQJ8:Ndufb9; Q9CQZ5:Ndufa6; Q9CR61:Ndufb7; Q9CR68:Uqcrfs1; Q9CWG8:Ndufaf7; Q9CXP8:Gng10; Q9CZW4:Acsl3; Q9D0M3:Cyc1; Q9D1H6:Ndufaf4; Q9D2R6:Coa3; Q9D6J5:Ndufb8; Q9D6J6:Ndufv2; Q9DB20:Atp5po; Q9DB77:Uqcrc2; Q9DC70:Ndufs7; Q9DCJ5:Ndufa8; Q9DCS9:Ndufb10; Q9DCT2:Ndufs3; Q9DCX2:Atp5pd; Q9ERS2:Ndufa13; Q9JKL4:Ndufaf3; Q9Z1P6:Ndufa7
Environmental adaptation	Organismal Systems	DEG	10	12.82	P63213:Gng2; P68181:Prkacb; Q63844:Mapk3; Q6PHZ2:Camk2d; Q9CPQ8:Atp5mg; Q9CQ91:Ndufa3; Q9CXP8:Gng10; Q9DCS9:Ndufb10; Q9ERS2:Ndufa13; Q9Z1P6:Ndufa7
Excretory system	Organismal Systems	ALL	30	3.53	D3Z7P3:Gls; G5E829:Atp2b1; P14152:Mdh1; P15208:Insr; P15920:Atp6v0a2; P17426:Ap2a1; P26443:Glud1; P46460:Nsf; P50516:Atp6v1a; P50518:Atp6v1e1; P51863:Atp6v0d1; P62814:Atp6v1b2; P63085:Mapk1; P63094:Gnas; P63168:Dynll1; P68181:Prkacb; P70452:Stx4; Q61599:Arhgdib; Q63844:Mapk3; Q68FD5:Cltc; Q8BH04:Pck2; Q8VDN2:Atp1a1; Q99PT1:Arhgdia; Q9CQD1:Rab5a; Q9D0M5:Dynll2; Q9D1K2:Atp6v1f; Q9DBG3:Ap2b1; Q9JHL1:Slc9a3r2; Q9JHU4:Dync1h1; Q9QZD8:Slc25a10
Excretory system	Organismal Systems	DEG	4	5.13	P15920:Atp6v0a2; P51863:Atp6v0d1; P68181:Prkacb; Q63844:Mapk3
Immune system	Organismal Systems	ALL	68	8.01	O54890:Itgb3; O88792:F11r; P01027:C3; P08752:Gnai2; P09055:Itgb1; P0DP28:Calm3; P10639:Txn; P11881:Itpr1; P15066:Jund; P25799:Nfkb1; P26039:Tln1; P26041:Msn; P27773:Pdia3; P28667:Marcksl1; P28862:Mmp3; P34152:Ptk2; P35235:Ptpn11; P40240:Cd9; P52432:Polr1c; P60521:Gabarapl2; P60766:Cdc42; P62071:Rras2; P62137:Ppp1ca; P62141:Ppp1cb; P62835:Rap1a; P63085:Mapk1; P63094:Gnas; P63213:Gng2; P68181:Prkacb; P70227:Itpr3; P70302:Stim1; P70399:Tp53bp1; P70460:Vasp; P70677:Casp3; Q05769:Ptgs2; Q3THE2:Myl12b; Q3TL44:Nlrx1; Q3UMR5:Mcu; Q3UYH7:Adrbk2; Q60930:Vdac2; Q61210:Arhgef1; Q61301:Ctnna2; Q61411:Hras; Q62074:Prkci; Q62469:Itga2; Q62470:Itga3; Q63844:Mapk3; Q64695:Procr; Q64727:Vcl; Q6PDM2:Srsf1; Q7TPR4:Actn1; Q80VY9:Dhx33; Q811U4:Mfn1; Q8CIN4:Pak2; Q8VCF0:Mavs; Q923G2:Polr2h; Q99M51:Nck1; Q9CVB6:Arpc2; Q9CX34:Sugt1; Q9CXP8:Gng10; Q9D898:Arpc5l; Q9DAX2:Plpp2; Q9DBR7:Ppp1r12a; Q9ES74:Nek7; Q9ESY9:Ifi30; Q9JM76:Arpc3; Q9QZM4:Tnfrsf10b; Q9QZQ1:Afdn
Immune system	Organismal Systems	DEG	13	16.67	P28862:Mmp3; P52432:Polr1c; P60766:Cdc42; P62141:Ppp1cb; P63213:Gng2; P68181:Prkacb; Q3UMR5:Mcu; Q3UYH7:Adrbk2; Q61301:Ctnna2; Q63844:Mapk3; Q923G2:Polr2h; Q9CXP8:Gng10; Q9D898:Arpc5l
Nervous system	Organismal Systems	ALL	66	7.77	D3Z7P3:Gls; O08599:Stxbp1; O88587:Comt; P08752:Gnai2; P0DP28:Calm3; P11881:Itpr1; P15920:Atp6v0a2; P17426:Ap2a1; P25799:Nfkb1; P35235:Ptpn11; P46460:Nsf; P50516:Atp6v1a; P50518:Atp6v1e1; P51863:Atp6v0d1; P52503:Ndufs6; P60521:Gabarapl2; P60766:Cdc42; P62137:Ppp1ca; P62141:Ppp1cb; P62715:Ppp2cb; P62814:Atp6v1b2; P62835:Rap1a; P63085:Mapk1; P63094:Gnas; P63213:Gng2; P68181:Prkacb; P70227:Itpr3; P70677:Casp3; Q05769:Ptgs2; Q3UYH7:Adrbk2; Q61411:Hras; Q61599:Arhgdib; Q61768:Kif5b; Q62425:Ndufa4; Q63844:Mapk3; Q68FD5:Cltc; Q6PHZ2:Camk2d; Q76MZ3:Ppp2r1a; Q7TMF3:Ndufa12; Q7TNP2:Ppp2r1b; Q8CFE6:Slc38a2; Q8K2P7:Slc38a1; Q91VD9:Ndufs1; Q91WD5:Ndufs2; Q99LC3:Ndufa10; Q99LY9:Ndufs5; Q99PT1:Arhgdia; Q9CPP6:Ndufa5; Q9CQ54:Ndufc2; Q9CQ75:Ndufa2; Q9CQ91:Ndufa3; Q9CQJ8:Ndufb9; Q9CQZ5:Ndufa6; Q9CR61:Ndufb7; Q9CXP8:Gng10; Q9D1K2:Atp6v1f; Q9D6J5:Ndufb8; Q9D6J6:Ndufv2; Q9DB05:Napa; Q9DBG3:Ap2b1; Q9DC70:Ndufs7; Q9DCJ5:Ndufa8; Q9DCS9:Ndufb10; Q9DCT2:Ndufs3; Q9ERS2:Ndufa13; Q9Z1P6:Ndufa7
Nervous system	Organismal Systems	DEG	14	17.95	P15920:Atp6v0a2; P51863:Atp6v0d1; P60766:Cdc42; P62141:Ppp1cb; P63213:Gng2; P68181:Prkacb; Q3UYH7:Adrbk2; Q63844:Mapk3; Q6PHZ2:Camk2d; Q9CQ91:Ndufa3; Q9CXP8:Gng10; Q9DCS9:Ndufb10; Q9ERS2:Ndufa13; Q9Z1P6:Ndufa7
Sensory system	Organismal Systems	ALL	9	1.06	P0DP28:Calm3; P11881:Itpr1; P62137:Ppp1ca; P62141:Ppp1cb; P63094:Gnas; P68181:Prkacb; P70227:Itpr3; Q3UYH7:Adrbk2; Q6PHZ2:Camk2d
Sensory system	Organismal Systems	DEG	4	5.13	P62141:Ppp1cb; P68181:Prkacb; Q3UYH7:Adrbk2; Q6PHZ2:Camk2d
Amino acid metabolism	Metabolism	ALL	51	6.01	B2RQC6:Cad; D3Z7P3:Gls; E9Q5F9:Setd2; O08749:Dld; O88508:Dnmt3a; O88587:Comt; O88986:Gcat; P05201:Got1; P05202:Got2; P08249:Mdh2; P13864:Dnmt1; P14152:Mdh1; P26443:Glud1; P45952:Acadm; P47856:Gfpt1; P55200:Kmt2a; P70351:Ezh1; Q07417:Acads; Q3URE1:Acsf3; Q60715:P4ha1; Q60759:Gcdh; Q61024:Asns; Q61425:Hadh; Q61753:Phgdh; Q6P3A8:Bckdhb; Q80SW1:Ahcyl1; Q8BGT5:Gpt2; Q8BH95:Echs1; Q8BMS1:Hadha; Q8BVE8:Nsd2; Q8BWT1:Acaa2; Q8K297:Colgalt1; Q8QZS1:Hibch; Q8QZT1:Acat1; Q91WC0:Setd3; Q91WK5:Gcsh; Q921H8:Acaa1a; Q99J99:Mpst; Q99JY0:Hadhb; Q99L13:Hibadh; Q99MR8:Mccc1; Q9CPY7:Lap3; Q9CQ65:Mtap; Q9CZN7:Shmt2; Q9D0K2:Oxct1; Q9D2G2:Dlst; Q9DBF1:Aldh7a1; Q9JHI5:Ivd; Q9R0B9:Plod2; Q9R0E1:Plod3; Q9WU79:Prodh
Amino acid metabolism	Metabolism	DEG	5	6.41	E9Q5F9:Setd2; P70351:Ezh1; Q3URE1:Acsf3; Q80SW1:Ahcyl1; Q91WK5:Gcsh
Biosynthesis of other secondary metabolites	Metabolism	ALL	1	0.12	O08528:Hk2
Carbohydrate metabolism	Metabolism	ALL	61	7.18	O08528:Hk2; O08749:Dld; P06745:Gpi; P08249:Mdh2; P09411:Pgk1; P12382:Pfkl; P14152:Mdh1; P17751:Tpi1; P21550:Eno3; P28271:Aco1; P40142:Tkt; P45377:Akr1b8; P47856:Gfpt1; P52480:Pkm; P54071:Idh2; P70699:Gaa; P97807:Fh; Q07417:Acads; Q2TBE6:Pi4k2a; Q3TW96:Uap1l1; Q5SWU9:Acaca; Q60597:Ogdh; Q61425:Hadh; Q6P3A8:Bckdhb; Q7TNG8:Ldhd; Q80V26:Impad1; Q8BH04:Pck2; Q8BH95:Echs1; Q8BKZ9:Pdhx; Q8BMF4:Dlat; Q8BMS1:Hadha; Q8CBQ5:Pi4k2b; Q8CFX1:H6pd; Q8K2B3:Sdha; Q8K2J0:Plcd3; Q8QZS1:Hibch; Q8QZT1:Acat1; Q91WK5:Gcsh; Q91XL3:Uxs1; Q91YP0:L2hgdh; Q93092:Taldo1; Q99J77:Nans; Q99KE1:Me2; Q99KI0:Aco2; Q9CQ60:Pgls; Q9CZN7:Shmt2; Q9CZU6:Cs; Q9D051:Pdhb; Q9D0K2:Oxct1; Q9D2G2:Dlst; Q9D6R2:Idh3a; Q9DB73:Cyb5r1; Q9DBF1:Aldh7a1; Q9DCN2:Cyb5r3; Q9EP69:Sacm1l; Q9JHU9:Isyna1; Q9R0H0:Acox1; Q9WUM5:Suclg1; Q9Z2I8:Suclg2; Q9Z2I9:Sucla2; Q9Z2L6:Minpp1
Carbohydrate metabolism	Metabolism	DEG	5	6.41	P21550:Eno3; P45377:Akr1b8; Q80V26:Impad1; Q91WK5:Gcsh; Q91YP0:L2hgdh
Energy metabolism	Metabolism	ALL	53	6.24	P12787:Cox5a; P15920:Atp6v0a2; P17665:Cox7c; P26443:Glud1; P43024:Cox6a1; P48771:Cox7a2; P50516:Atp6v1a; P50518:Atp6v1e1; P51863:Atp6v0d1; P52503:Ndufs6; P56391:Cox6b1; P56480:Atp5f1b; P62814:Atp6v1b2; P97450:Atp5pf; P99028:Uqcrh; Q03265:Atp5f1a; Q62425:Ndufa4; Q7TMF3:Ndufa12; Q80V26:Impad1; Q8BJ03:Cox15; Q8K2B3:Sdha; Q91VD9:Ndufs1; Q91VM9:Ppa2; Q91WD5:Ndufs2; Q99J99:Mpst; Q99LC3:Ndufa10; Q99LY9:Ndufs5; Q9CPP6:Ndufa5; Q9CPQ1:Cox6c; Q9CPQ8:Atp5mg; Q9CQ54:Ndufc2; Q9CQ69:Uqcrq; Q9CQ75:Ndufa2; Q9CQ91:Ndufa3; Q9CQJ8:Ndufb9; Q9CQZ5:Ndufa6; Q9CR61:Ndufb7; Q9CR68:Uqcrfs1; Q9D0M3:Cyc1; Q9D1K2:Atp6v1f; Q9D6J5:Ndufb8; Q9D6J6:Ndufv2; Q9DB20:Atp5po; Q9DB77:Uqcrc2; Q9DC70:Ndufs7; Q9DCJ5:Ndufa8; Q9DCM0:Ethe1; Q9DCS9:Ndufb10; Q9DCT2:Ndufs3; Q9DCX2:Atp5pd; Q9ERS2:Ndufa13; Q9QZA0:Ca5b; Q9Z1P6:Ndufa7
Energy metabolism	Metabolism	DEG	8	10.26	P15920:Atp6v0a2; P51863:Atp6v0d1; Q80V26:Impad1; Q9CPQ8:Atp5mg; Q9CQ91:Ndufa3; Q9DCS9:Ndufb10; Q9ERS2:Ndufa13; Q9Z1P6:Ndufa7
Glycan biosynthesis and metabolism	Metabolism	ALL	24	2.83	O08912:Galnt1; O70152:Dpm1; P27046:Man2a1; P39098:Man1a2; P61804:Dad1; P70419:Galnt3; Q6P8H8:Alg8; Q80VA0:Galnt7; Q8BHN3:Ganab; Q8BWP8:B4gat1; Q8BYB9:Poglut1; Q8CGY8:Ogt; Q8K297:Colgalt1; Q8R3H7:Hs2st1; Q8VDI9:Alg9; Q91ZW2:Pofut1; Q99J27:Slc33a1; Q9CXY9:Pigk; Q9D1Q4:Dpm3; Q9DB25:Alg5; Q9DBE8:Alg2; Q9JMK0:B4galt5; Q9R0E1:Plod3; Q9WTK3:Gpaa1
Glycan biosynthesis and metabolism	Metabolism	DEG	3	3.85	O70152:Dpm1; Q9CXY9:Pigk; Q9D1Q4:Dpm3
Lipid metabolism	Metabolism	ALL	55	6.48	O09005:Degs1; O70572:Smpd2; O88587:Comt; P11352:Gpx1; P13011:Scd2; P32020:Scp2; P42125:Eci1; P45377:Akr1b8; P45952:Acadm; P50428:Arsa; P50544:Acadvl; P70245:Ebp; Q05769:Ptgs2; Q07417:Acads; Q3TFD2:Lpcat1; Q3URE1:Acsf3; Q5SWU9:Acaca; Q60759:Gcdh; Q61425:Hadh; Q61586:Gpam; Q64521:Gpd2; Q6NVG1:Lpcat4; Q6ZPR5:Smpd4; Q8BH95:Echs1; Q8BLN5:Lss; Q8BMS1:Hadha; Q8BWM0:Ptges2; Q8BWT1:Acaa2; Q8C0I1:Agps; Q8CHK3:Mboat7; Q8K0C4:Cyp51a1; Q8K2C9:Hacd3; Q8K4X7:Agpat4; Q8QZT1:Acat1; Q8R3F5:Mcat; Q8VCH6:Dhcr24; Q91V01:Lpcat3; Q91V12:Acot7; Q91VT4:Cbr4; Q920L1:Fads1; Q921H8:Acaa1a; Q924Z4:Cers2; Q99JY0:Hadhb; Q9CRA4:Msmo1; Q9CRY7:Gdpd1; Q9CY27:Tecr; Q9CZW4:Acsl3; Q9D0K2:Oxct1; Q9D517:Agpat3; Q9D7B7:Gpx8; Q9DAX2:Plpp2; Q9DBF1:Aldh7a1; Q9DCS3:Mecr; Q9ESW4:Agk; Q9R0H0:Acox1
Lipid metabolism	Metabolism	DEG	4	5.13	P11352:Gpx1; P45377:Akr1b8; Q3URE1:Acsf3; Q91VT4:Cbr4
Metabolism of cofactors and vitamins	Metabolism	ALL	16	1.88	P36552:Cpox; P45377:Akr1b8; P48760:Fpgs; P53702:Hccs; Q3V3R1:Mthfd1l; Q64737:Gart; Q6TEK5:Vkorc1l1; Q8BJ03:Cox15; Q8C5H8:Nadk2; Q8R1S0:Coq6; Q9CWJ9:Atic; Q9CZN7:Shmt2; Q9D020:Nt5c3a; Q9DBL7:Coasy; Q9JM14:Nt5c; Q9WTP6:Ak2
Metabolism of cofactors and vitamins	Metabolism	DEG	1	1.28	P45377:Akr1b8
Metabolism of other amino acids	Metabolism	ALL	23	2.71	D3Z7P3:Gls; O09131:Gsto1; P07742:Rrm1; P11352:Gpx1; P15626:Gstm2; P19157:Gstp1; P26443:Glud1; P54071:Idh2; Q07417:Acads; Q68FL6:Mars; Q6PDY2:Ado; Q8BH69:Sephs1; Q8BH86:Dglucy; Q8BH95:Echs1; Q8BMS1:Hadha; Q8QZS1:Hibch; Q9CPU4:Mgst3; Q9CPY7:Lap3; Q9CQU0:Txndc12; Q9D7B7:Gpx8; Q9DBF1:Aldh7a1; Q9JMH6:Txnrd1; Q9R0H0:Acox1
Metabolism of other amino acids	Metabolism	DEG	2	2.56	P11352:Gpx1; Q9CPU4:Mgst3
Metabolism of terpenoids and polyketides	Metabolism	ALL	4	0.47	P58044:Idi1; Q33DR2:Pdss1; Q33DR3:Pdss2; Q8QZT1:Acat1
Nucleotide metabolism	Metabolism	ALL	20	2.36	B2RQC6:Cad; O35435:Dhodh; P04184:Tk1; P07742:Rrm1; P08030:Aprt; P52480:Pkm; P55264:Adk; P70698:Ctps1; Q5SUR0:Pfas; Q64737:Gart; Q8BTJ4:Enpp4; Q9CWJ9:Atic; Q9D020:Nt5c3a; Q9DBP5:Cmpk1; Q9DCL9:Paics; Q9JKX6:Nudt5; Q9JM14:Nt5c; Q9WTP6:Ak2; Q9WTP7:Ak3; Q9WV84:Nme4
Nucleotide metabolism	Metabolism	DEG	1	1.28	P55264:Adk
Xenobiotics biodegradation and metabolism	Metabolism	ALL	9	1.06	O09131:Gsto1; P04184:Tk1; P07742:Rrm1; P15626:Gstm2; P19157:Gstp1; Q8CG76:Akr7a2; Q9CPU4:Mgst3; Q9DBP5:Cmpk1; Q9WV84:Nme4
Xenobiotics biodegradation and metabolism	Metabolism	DEG	1	1.28	Q9CPU4:Mgst3
Cancer: overview	Human Diseases	ALL	89	10.48	A2AN08:Ubr4; D3Z7P3:Gls; E9Q5G3:Kif23; O08528:Hk2; O09131:Gsto1; O54890:Itgb3; O88508:Dnmt3a; O88712:Ctbp1; P01027:C3; P02463:Col4a1; P08752:Gnai2; P09055:Itgb1; P0DP28:Calm3; P11881:Itpr1; P12382:Pfkl; P13864:Dnmt1; P15626:Gstm2; P19157:Gstp1; P25799:Nfkb1; P26041:Msn; P26043:Rdx; P28862:Mmp3; P34022:Ranbp1; P34152:Ptk2; P35235:Ptpn11; P51863:Atp6v0d1; P51943:Ccna2; P52480:Pkm; P52927:Hmga2; P55200:Kmt2a; P60766:Cdc42; P61025:Cks1b; P62071:Rras2; P62137:Ppp1ca; P62141:Ppp1cb; P62869:Elob; P62878:Rbx1; P63085:Mapk1; P63094:Gnas; P63101:Ywhaz; P63213:Gng2; P63280:Ube2i; P68181:Prkacb; P68510:Ywhah; P70227:Itpr3; P70677:Casp3; P84244:H3f3a; P84244:H3f3b; P97287:Mcl1; P97807:Fh; Q02257:Jup; Q05769:Ptgs2; Q05793:Hspg2; Q3U1J4:Ddb1; Q60520:Sin3a; Q60598:Cttn; Q61001:Lama5; Q61210:Arhgef1; Q61301:Ctnna2; Q61411:Hras; Q61553:Fscn1; Q62469:Itga2; Q62470:Itga3; Q63844:Mapk3; Q6PHZ2:Camk2d; Q7TPR4:Actn1; Q80U72:Scrib; Q80X90:Flnb; Q8BG95:Ppp1r12b; Q8BVE8:Nsd2; Q8BY89:Slc44a2; Q8K409:Polb; Q8VCL2:Sco2; Q8VHN8:Nudt16l1; Q8VHX6:Flnc; Q99J95:Cdk9; Q99N84:Mrps18b; Q9CPU4:Mgst3; Q9CPY3:Cdca5; Q9CXP8:Gng10; Q9D051:Pdhb; Q9D4H8:Cul2; Q9DAX2:Plpp2; Q9DBR7:Ppp1r12a; Q9JIW9:Ralb; Q9JKF1:Iqgap1; Q9JMH6:Txnrd1; Q9WTX8:Mad1l1; Q9WVC3:Cav2
Cancer: overview	Human Diseases	DEG	17	21.79	A2AN08:Ubr4; P28862:Mmp3; P51863:Atp6v0d1; P51943:Ccna2; P60766:Cdc42; P61025:Cks1b; P62141:Ppp1cb; P63213:Gng2; P68181:Prkacb; P84244:H3f3a; P84244:H3f3b; Q61301:Ctnna2; Q63844:Mapk3; Q6PHZ2:Camk2d; Q8VHN8:Nudt16l1; Q9CPU4:Mgst3; Q9CXP8:Gng10
Cancer: specific types	Human Diseases	ALL	40	4.71	A2BH40:Arid1a; E9Q7E2:Arid2; O09131:Gsto1; O54941:Smarce1; O55222:Ilk; O88665:Brd7; O88712:Ctbp1; P02463:Col4a1; P09055:Itgb1; P0DP28:Calm3; P15626:Gstm2; P19157:Gstp1; P25799:Nfkb1; P28862:Mmp3; P34152:Ptk2; P35235:Ptpn11; P60766:Cdc42; P61025:Cks1b; P62835:Rap1a; P62869:Elob; P62878:Rbx1; P63085:Mapk1; P70677:Casp3; P97807:Fh; Q02257:Jup; Q05769:Ptgs2; Q3TKT4:Smarca4; Q61001:Lama5; Q61301:Ctnna2; Q61411:Hras; Q62469:Itga2; Q62470:Itga3; Q63844:Mapk3; Q6PHZ2:Camk2d; Q8CIN4:Pak2; Q99JR8:Smarcd2; Q9CPU4:Mgst3; Q9D4H8:Cul2; Q9JIW9:Ralb; Q9JMH6:Txnrd1
Cancer: specific types	Human Diseases	DEG	7	8.97	P28862:Mmp3; P60766:Cdc42; P61025:Cks1b; Q61301:Ctnna2; Q63844:Mapk3; Q6PHZ2:Camk2d; Q9CPU4:Mgst3
Cardiovascular disease	Human Diseases	ALL	27	3.18	A2A863:Itgb4; E9Q557:Dsp; O09131:Gsto1; O54890:Itgb3; O55143:Atp2a2; P09055:Itgb1; P0DP28:Calm3; P10639:Txn; P15626:Gstm2; P19157:Gstp1; P23242:Gja1; P25799:Nfkb1; P34152:Ptk2; P48678:Lmna; P63094:Gnas; P63166:Sumo1; P68181:Prkacb; P70677:Casp3; P97792:Cxadr; Q02257:Jup; Q61301:Ctnna2; Q62469:Itga2; Q62470:Itga3; Q64337:Sqstm1; Q6IRU2:Tpm4; Q9CPU4:Mgst3; Q9WVC3:Cav2
Cardiovascular disease	Human Diseases	DEG	3	3.85	P68181:Prkacb; Q61301:Ctnna2; Q9CPU4:Mgst3
Drug resistance: antineoplastic	Human Diseases	ALL	21	2.47	B2RX12:Abcc3; O09131:Gsto1; P15626:Gstm2; P19157:Gstp1; P25799:Nfkb1; P34152:Ptk2; P48760:Fpgs; P63085:Mapk1; P63094:Gnas; P68181:Prkacb; P70677:Casp3; Q01320:Top2a; Q61411:Hras; Q63844:Mapk3; Q64430:Atp7a; Q64511:Top2b; Q64737:Gart; Q9CPU4:Mgst3; Q9CWJ9:Atic; Q9CZN7:Shmt2; Q9WVG6:Carm1
Drug resistance: antineoplastic	Human Diseases	DEG	4	5.13	P68181:Prkacb; Q63844:Mapk3; Q64430:Atp7a; Q9CPU4:Mgst3
Endocrine and metabolic disease	Human Diseases	ALL	66	7.77	O08528:Hk2; O08915:Aip; P02463:Col4a1; P08752:Gnai2; P11881:Itpr1; P12787:Cox5a; P15208:Insr; P17665:Cox7c; P25799:Nfkb1; P35235:Ptpn11; P43024:Cox6a1; P47856:Gfpt1; P48771:Cox7a2; P52480:Pkm; P52503:Ndufs6; P55200:Kmt2a; P56391:Cox6b1; P60766:Cdc42; P61965:Wdr5; P62137:Ppp1ca; P62141:Ppp1cb; P62835:Rap1a; P63038:Hspd1; P63085:Mapk1; P63094:Gnas; P68181:Prkacb; P70227:Itpr3; P70677:Casp3; P97807:Fh; P99028:Uqcrh; Q61009:Scarb1; Q61411:Hras; Q62425:Ndufa4; Q63844:Mapk3; Q6PHZ2:Camk2d; Q6ZWX6:Eif2s1; Q7TMF3:Ndufa12; Q8BH04:Pck2; Q8BLF1:Nceh1; Q8CGY8:Ogt; Q8K2B3:Sdha; Q8K2J0:Plcd3; Q91VD9:Ndufs1; Q91WD5:Ndufs2; Q99LC3:Ndufa10; Q99LY9:Ndufs5; Q9CPP6:Ndufa5; Q9CPQ1:Cox6c; Q9CQ54:Ndufc2; Q9CQ69:Uqcrq; Q9CQ75:Ndufa2; Q9CQ91:Ndufa3; Q9CQJ8:Ndufb9; Q9CQZ5:Ndufa6; Q9CR61:Ndufb7; Q9CR68:Uqcrfs1; Q9D0M3:Cyc1; Q9D6J5:Ndufb8; Q9D6J6:Ndufv2; Q9DB77:Uqcrc2; Q9DC70:Ndufs7; Q9DCJ5:Ndufa8; Q9DCS9:Ndufb10; Q9DCT2:Ndufs3; Q9ERS2:Ndufa13; Q9Z1P6:Ndufa7
Endocrine and metabolic disease	Human Diseases	DEG	9	11.54	P60766:Cdc42; P62141:Ppp1cb; P68181:Prkacb; Q63844:Mapk3; Q6PHZ2:Camk2d; Q9CQ91:Ndufa3; Q9DCS9:Ndufb10; Q9ERS2:Ndufa13; Q9Z1P6:Ndufa7
Immune disease	Human Diseases	ALL	16	1.88	P01027:C3; P15920:Atp6v0a2; P25799:Nfkb1; P27048:Snrpb; P27661:H2afx; P28862:Mmp3; P50516:Atp6v1a; P50518:Atp6v1e1; P51863:Atp6v0d1; P62315:Snrpd1; P62814:Atp6v1b2; P84244:H3f3a; P84244:H3f3b; Q7TPR4:Actn1; Q9D1K2:Atp6v1f; Q9QZQ8:H2afy
Immune disease	Human Diseases	DEG	8	10.26	P15920:Atp6v0a2; P27661:H2afx; P28862:Mmp3; P51863:Atp6v0d1; P62315:Snrpd1; P84244:H3f3a; P84244:H3f3b; Q9QZQ8:H2afy
Infectious disease: bacterial	Human Diseases	ALL	37	4.36	O08547:Sec22b; O55222:Ilk; P01027:C3; P08752:Gnai2; P09055:Itgb1; P0DP28:Calm3; P15920:Atp6v0a2; P22518:Clk1; P25799:Nfkb1; P34152:Ptk2; P38647:Hspa9; P42208:Septin2; P51863:Atp6v0d1; P60766:Cdc42; P63038:Hspd1; P63085:Mapk1; P70677:Casp3; Q01853:Vcp; Q60598:Cttn; Q61210:Arhgef1; Q61301:Ctnna2; Q63844:Mapk3; Q64727:Vcl; Q68FD5:Cltc; Q6PHZ2:Camk2d; Q6Y5D8:Arhgap10; Q80X90:Flnb; Q8BKX1:Baiap2; Q8BL66:Eea1; Q8CHH9:Septin8; Q8VHX6:Flnc; Q9CQD1:Rab5a; Q9CVB6:Arpc2; Q9D898:Arpc5l; Q9JHU4:Dync1h1; Q9JM76:Arpc3; Q9WVC3:Cav2
Infectious disease: bacterial	Human Diseases	DEG	7	8.97	P15920:Atp6v0a2; P51863:Atp6v0d1; P60766:Cdc42; Q61301:Ctnna2; Q63844:Mapk3; Q6PHZ2:Camk2d; Q9D898:Arpc5l
Infectious disease: parasitic	Human Diseases	ALL	21	2.47	P01027:C3; P02463:Col4a1; P08752:Gnai2; P09055:Itgb1; P25799:Nfkb1; P28667:Marcksl1; P34152:Ptk2; P62715:Ppp2cb; P63085:Mapk1; P63094:Gnas; P68181:Prkacb; P70677:Casp3; Q05769:Ptgs2; Q61001:Lama5; Q63844:Mapk3; Q64727:Vcl; Q76MZ3:Ppp2r1a; Q7TNP2:Ppp2r1b; Q7TPR4:Actn1; Q99KR7:Ppif; Q9CQD1:Rab5a
Infectious disease: parasitic	Human Diseases	DEG	2	2.56	P68181:Prkacb; Q63844:Mapk3
Infectious disease: viral	Human Diseases	ALL	97	11.43	A2A6Q5:Cdc27; A2A863:Itgb4; A2AN08:Ubr4; O08583:Alyref; O35226:Psmd4; O35326:Srsf5; O35593:Psmd14; O54890:Itgb3; O88574:Sap30; P01027:C3; P02463:Col4a1; P08752:Gnai2; P09055:Itgb1; P0DP28:Calm3; P11881:Itpr1; P14685:Psmd3; P15920:Atp6v0a2; P22892:Ap1g1; P25799:Nfkb1; P26039:Tln1; P26041:Msn; P27773:Pdia3; P34022:Ranbp1; P34152:Ptk2; P35235:Ptpn11; P46471:Psmc2; P48962:Slc25a4; P50516:Atp6v1a; P50518:Atp6v1e1; P51863:Atp6v0d1; P51943:Ccna2; P52480:Pkm; P54775:Psmc4; P60521:Gabarapl2; P60766:Cdc42; P61967:Ap1s1; P62137:Ppp1ca; P62141:Ppp1cb; P62196:Psmc5; P62715:Ppp2cb; P62814:Atp6v1b2; P62869:Elob; P62878:Rbx1; P63085:Mapk1; P63094:Gnas; P63101:Ywhaz; P63213:Gng2; P68040:Rack1; P68181:Prkacb; P68510:Ywhah; P70227:Itpr3; P70677:Casp3; Q05769:Ptgs2; Q05793:Hspg2; Q3TCH7:Cul4a; Q3TL44:Nlrx1; Q3TWW8:Srsf6; Q3TXS7:Psmd1; Q3U1J4:Ddb1; Q60520:Sin3a; Q60930:Vdac2; Q60960:Kpna1; Q61001:Lama5; Q61009:Scarb1; Q61191:Hcfc1; Q61210:Arhgef1; Q61411:Hras; Q62074:Prkci; Q62093:Srsf2; Q62469:Itga2; Q62470:Itga3; Q63844:Mapk3; Q6P5F9:Xpo1; Q6PDM2:Srsf1; Q6ZWX6:Eif2s1; Q76MZ3:Ppp2r1a; Q7TNP2:Ppp2r1b; Q80U72:Scrib; Q80Y17:Llgl1; Q8BQZ5:Cpsf4; Q8C570:Rae1; Q8CCS6:Pabpn1; Q8CHW4:Eif2b5; Q8CIN4:Pak2; Q8K409:Polb; Q8R2Q8:Bst2; Q8VCF0:Mavs; Q8VDM6:Hnrnpul1; Q99JI4:Psmd6; Q99JX7:Nxf1; Q9CT10:Ranbp3; Q9CXP8:Gng10; Q9D0B0:Srsf9; Q9D1K2:Atp6v1f; Q9QZM4:Tnfrsf10b; Q9QZV9:Nxt1; Q9WTX8:Mad1l1
Infectious disease: viral	Human Diseases	DEG	13	16.67	A2A6Q5:Cdc27; A2AN08:Ubr4; O88574:Sap30; P15920:Atp6v0a2; P22892:Ap1g1; P51863:Atp6v0d1; P51943:Ccna2; P60766:Cdc42; P62141:Ppp1cb; P63213:Gng2; P68181:Prkacb; Q63844:Mapk3; Q9CXP8:Gng10
Neurodegenerative disease	Human Diseases	ALL	72	8.48	O08529:Capn2; O35598:Adam10; O55143:Atp2a2; P08228:Sod1; P08752:Gnai2; P0DP28:Calm3; P11352:Gpx1; P11881:Itpr1; P12787:Cox5a; P17426:Ap2a1; P17665:Cox7c; P21981:Tgm2; P43024:Cox6a1; P48771:Cox7a2; P48962:Slc25a4; P52503:Ndufs6; P56391:Cox6b1; P56480:Atp5f1b; P60898:Polr2i; P62488:Polr2g; P63085:Mapk1; P68181:Prkacb; P70227:Itpr3; P70677:Casp3; P97450:Atp5pf; P97760:Polr2c; P99028:Uqcrh; Q03265:Atp5f1a; Q60520:Sin3a; Q60930:Vdac2; Q62425:Ndufa4; Q63844:Mapk3; Q68FD5:Cltc; Q7TMF3:Ndufa12; Q8CFI7:Polr2b; Q8K2B3:Sdha; Q8VD75:Hip1; Q91VD9:Ndufs1; Q91WD5:Ndufs2; Q923G2:Polr2h; Q99KR7:Ppif; Q99LC3:Ndufa10; Q99LX0:Park7; Q99LY9:Ndufs5; Q99P72:Rtn4; Q9CPP6:Ndufa5; Q9CPQ1:Cox6c; Q9CQ54:Ndufc2; Q9CQ69:Uqcrq; Q9CQ75:Ndufa2; Q9CQ91:Ndufa3; Q9CQD1:Rab5a; Q9CQJ8:Ndufb9; Q9CQZ5:Ndufa6; Q9CR61:Ndufb7; Q9CR68:Uqcrfs1; Q9D0M3:Cyc1; Q9D6J5:Ndufb8; Q9D6J6:Ndufv2; Q9D7M8:Polr2d; Q9DB20:Atp5po; Q9DB77:Uqcrc2; Q9DBG3:Ap2b1; Q9DC70:Ndufs7; Q9DCJ5:Ndufa8; Q9DCS9:Ndufb10; Q9DCT2:Ndufs3; Q9DCX2:Atp5pd; Q9ERS2:Ndufa13; Q9ES97:Rtn3; Q9QYA2:Tomm40; Q9Z1P6:Ndufa7
Neurodegenerative disease	Human Diseases	DEG	9	11.54	P11352:Gpx1; P60898:Polr2i; P68181:Prkacb; Q63844:Mapk3; Q923G2:Polr2h; Q9CQ91:Ndufa3; Q9DCS9:Ndufb10; Q9ERS2:Ndufa13; Q9Z1P6:Ndufa7
Substance dependence	Human Diseases	ALL	19	2.24	P08752:Gnai2; P0DP28:Calm3; P25799:Nfkb1; P27661:H2afx; P62137:Ppp1ca; P62141:Ppp1cb; P63085:Mapk1; P63094:Gnas; P63213:Gng2; P68181:Prkacb; P84244:H3f3a; P84244:H3f3b; Q3UYH7:Adrbk2; Q61411:Hras; Q63844:Mapk3; Q6PHZ2:Camk2d; Q8BY71:Hat1; Q9CXP8:Gng10; Q9QZQ8:H2afy
Substance dependence	Human Diseases	DEG	11	14.1	P27661:H2afx; P62141:Ppp1cb; P63213:Gng2; P68181:Prkacb; P84244:H3f3a; P84244:H3f3b; Q3UYH7:Adrbk2; Q63844:Mapk3; Q6PHZ2:Camk2d; Q9CXP8:Gng10; Q9QZQ8:H2afy
"Folding, sorting and degradation"	Genetic Information Processing	ALL	106	12.49	A2A6Q5:Cdc27; A2BDX3:Mocs3; G5E870:Trip12; O08529:Capn2; O08547:Sec22b; O35226:Psmd4; O35593:Psmd14; O55234:Psmb5; O88630:Gosr1; O88983:Stx8; P08003:Pdia4; P12382:Pfkl; P14576:Srp54; P14685:Psmd3; P16254:Srp14; P21550:Eno3; P27612:Plaa; P27773:Pdia3; P38647:Hspa9; P39098:Man1a2; P46471:Psmc2; P47758:Srprb; P48722:Hspa4l; P49722:Psma2; P54775:Psmc4; P54823:Ddx6; P57759:Erp29; P60904:Dnajc5; P61804:Dad1; P62196:Psmc5; P62311:Lsm3; P62869:Elob; P62878:Rbx1; P63024:Vamp3; P63038:Hspd1; P63280:Ube2i; P70280:Vamp7; P70452:Stx4; P99026:Psmb4; Q01853:Vcp; Q3TCH7:Cul4a; Q3TXS7:Psmd1; Q3U1J4:Ddb1; Q3UPL0:Sec31a; Q60692:Psmb6; Q61699:Hsph1; Q6P5E4:Uggt1; Q6QD59:Bnip1; Q6ZQ89:March6; Q6ZWM4:Lsm8; Q6ZWQ7:Spcs3; Q6ZWX6:Eif2s1; Q7TMY8:Huwe1; Q8BHN3:Ganab; Q8BMA6:Srp68; Q8BMK4:Ckap4; Q8BTW3:Exosc6; Q8BU14:Sec62; Q8K1E0:Stx5; Q8K1R3:Pnpt1; Q8R317:Ubqln1; Q8VDS8:Stx18; Q8VHE0:Sec63; Q91YN9:Bag2; Q922R8:Pdia6; Q99J99:Mpst; Q99JI4:Psmd6; Q99KP6:Prpf19; Q99KV1:Dnajb11; Q99NB8:Ubqln4; Q99P31:Hspbp1; Q9CQ56:Use1; Q9CQS8:Sec61b; Q9CQW1:Ykt6; Q9CRA8:Exosc5; Q9CSH3:Dis3; Q9CYN2:Spcs2; Q9CZ44:Nsfl1c; Q9CZU3:Mtrex; Q9D074:Mgrn1; Q9D0F3:Lman1; Q9D0I4:Stx17; Q9D1M0:Sec13; Q9D1Q1:Mphosph6; Q9D4H8:Cul2; Q9DAA6:Exosc1; Q9DAR7:Dcps; Q9DBG7:Srpra; Q9DBH5:Lman2; Q9DBR1:Xrn2; Q9DC23:Dnajc10; Q9EPK6:Sil1; Q9ERB0:Snap29; Q9JHI7:Exosc9; Q9JKR6:Hyou1; Q9JLR1:Sec61a2; Q9JLV5:Cul3; Q9QUM9:Psma6; Q9QXA5:Lsm4; Q9QYI4:Dnajb12; Q9QYJ0:Dnaja2; Q9R1P0:Psma4; Q9R1P3:Psmb2; Q9R1T2:Sae1; Q9Z1F9:Uba2; Q9Z2G6:Sel1l
"Folding, sorting and degradation"	Genetic Information Processing	DEG	9	11.54	A2A6Q5:Cdc27; P21550:Eno3; P27612:Plaa; Q61699:Hsph1; Q6ZWQ7:Spcs3; Q7TMY8:Huwe1; Q9ERB0:Snap29; Q9QUM9:Psma6; Q9Z1F9:Uba2
Replication and repair	Genetic Information Processing	ALL	13	1.53	O88554:Parp2; P27641:Xrcc5; P37913:Lig1; P49718:Mcm5; P62878:Rbx1; P97310:Mcm2; Q3TCH7:Cul4a; Q3U1J4:Ddb1; Q8BH57:Wdr48; Q8K409:Polb; Q8VEE4:Rpa1; Q99J62:Rfc4; Q9CQ71:Rpa3
Replication and repair	Genetic Information Processing	DEG	1	1.28	Q8BH57:Wdr48
Transcription	Genetic Information Processing	ALL	76	8.95	B1AZI6:Thoc2; B2RY56:Rbm25; O08583:Alyref; O35326:Srsf5; P27048:Snrpb; P52432:Polr1c; P57784:Snrpa1; P59708:Sf3b6; P60335:Pcbp1; P60898:Polr2i; P61327:Magoh; P62305:Snrpe; P62309:Snrpg; P62311:Lsm3; P62315:Snrpd1; P62488:Polr2g; P62996:Tra2b; P63154:Crnkl1; P83870:Phf5a; P83877:Txnl4a; P97760:Polr2c; Q3THK3:Gtf2f1; Q3TIX9:Usp39; Q3TWW8:Srsf6; Q3UEB3:Puf60; Q3UYV9:Ncbp1; Q569Z5:Ddx46; Q62093:Srsf2; Q62189:Snrpa; Q69ZQ2:Isy1; Q6NV83:U2surp; Q6P4T2:Snrnp200; Q6PDM2:Srsf1; Q6PE01:Snrnp40; Q6PGH1:Bud31; Q6ZWM4:Lsm8; Q80SY5:Prpf38b; Q810A7:Ddx42; Q8BGT7:Smndc1; Q8BHJ9:Slu7; Q8BHS3:Rbm22; Q8CCF0:Prpf31; Q8CFI7:Polr2b; Q8CGZ0:Cherp; Q8JZX4:Rbm17; Q8K194:Snrnp27; Q8K4Z5:Sf3a1; Q8QZY9:Sf3b4; Q8R3N6:Thoc1; Q8VE80:Thoc3; Q91VC3:Eif4a3; Q91YR7:Prpf6; Q922U1:Prpf3; Q922V4:Plrg1; Q923D4:Sf3b5; Q923G2:Polr2h; Q99KP6:Prpf19; Q99PV0:Prpf8; Q9CPW7:Zmat2; Q9CQ49:Ncbp2; Q9CQI7:Snrpb2; Q9CWL8:Ctnnbl1; Q9CWZ3:Rbm8a; Q9D0B0:Srsf9; Q9D0T1:Snu13; Q9D198:Syf2; Q9D287:Bcas2; Q9D7M8:Polr2d; Q9DC48:Cdc40; Q9JHS9:Cwc15; Q9QXA5:Lsm4; Q9QZH3:Ppie; Q9WV02:Rbmx; Q9Z1N5:Ddx39b; Q9Z204:Hnrnpc; Q9Z315:Sart1
Transcription	Genetic Information Processing	DEG	6	7.69	P52432:Polr1c; P60898:Polr2i; P62309:Snrpg; P62315:Snrpd1; Q922U1:Prpf3; Q923G2:Polr2h
Translation	Genetic Information Processing	ALL	161	18.96	B1AZI6:Thoc2; O08583:Alyref; O08784:Tcof1; O35218:Cpsf2; O35680:Mrps12; O35691:Pnn; O35972:Mrpl23; O70194:Eif3d; O88796:Rpp30; P14115:Rpl27a; P23116:Eif3a; P47963:Rpl13; P58742:Aaas; P61327:Magoh; P62137:Ppp1ca; P62141:Ppp1cb; P62274:Rps29; P62715:Ppp2cb; P62717:Rpl18a; P62830:Rpl23; P62843:Rps15; P62911:Rpl32; P62918:Rpl8; P63166:Sumo1; P63280:Ube2i; P99027:Rplp2; Q05D44:Eif5b; Q14CH7:Aars2; Q3TBW2:Mrpl10; Q3U186:Rars2; Q3U2A8:Vars2; Q3UM18:Lsg1; Q3UQ84:Tars2; Q3UYV9:Ncbp1; Q5U4D9:Thoc6; Q61584:Fxr1; Q640M1:Utp14a; Q68FL6:Mars; Q6DFW4:Nop58; Q6NVF9:Cpsf6; Q6P5F9:Xpo1; Q6ZQH8:Nup188; Q6ZQL4:Wdr43; Q6ZWN5:Rps9; Q6ZWV7:Rpl35; Q6ZWX6:Eif2s1; Q6ZWY3:Rps27l; Q76MZ3:Ppp2r1a; Q7TMB8:Cyfip1; Q7TMY4:Thoc7; Q7TNP2:Ppp2r1b; Q80U93:Nup214; Q80WS3:Fbll1; Q80X85:Mrps7; Q810V0:Mphosph10; Q8BH74:Nup107; Q8BHB4:Wdr3; Q8BIJ6:Iars2; Q8BIP0:Dars2; Q8BIQ5:Cstf2; Q8BJ71:Nup93; Q8BKT7:Thoc5; Q8BMJ3:Eif1ax; Q8BML9:Qars; Q8BP47:Nars; Q8BP67:Rpl24; Q8BQZ5:Cpsf4; Q8BTS4:Nup54; Q8BTV2:Cpsf7; Q8BU30:Iars; Q8BU88:Mrpl22; Q8BYL4:Yars2; Q8BYM8:Cars2; Q8C4J7:Tbl3; Q8C570:Rae1; Q8C7V3:Utp15; Q8CCS6:Pabpn1; Q8CFI5:Pars2; Q8CGC6:Rbm28; Q8CHP5:Pym1; Q8CHW4:Eif2b5; Q8CIG8:Prmt5; Q8JZQ9:Eif3b; Q8K1J6:Trnt1; Q8K224:Nat10; Q8K4P0:Wdr33; Q8R050:Gspt1; Q8R0G9:Nup133; Q8R1B4:Eif3c; Q8R2N2:Utp4; Q8R2U0:Seh1l; Q8R3N6:Thoc1; Q8R480:Nup85; Q8R4R6:Nup35; Q8R5K4:Nol6; Q8VCB1:Ndc1; Q8VCY6:Utp6; Q8VE80:Thoc3; Q8VHZ7:Imp4; Q91VC3:Eif4a3; Q921Y2:Imp3; Q924T2:Mrps2; Q99JX7:Nxf1; Q99KK9:Hars2; Q99L48:Nmd3; Q99LC2:Cstf1; Q99LI7:Cstf3; Q99M01:Fars2; Q99M28:Rnps1; Q99ME9:Gtpbp4; Q99N91:Mrpl34; Q99N92:Mrpl27; Q99N93:Mrpl16; Q99N96:Mrpl1; Q9CPR5:Mrpl15; Q9CPX7:Mrps16; Q9CQ06:Mrpl24; Q9CQ49:Ncbp2; Q9CQE3:Mrps17; Q9CQF0:Mrpl11; Q9CQF3:Nudt21; Q9CQS2:Nop10; Q9CR57:Rpl14; Q9CRB2:Nhp2; Q9CWU9:Nup37; Q9CWZ3:Rbm8a; Q9CXW4:Rpl11; Q9CY97:Ssu72; Q9CYK1:Wars2; Q9CZD3:Gars; Q9CZN8:Qrsl1; Q9CZX8:Rps19; Q9D0I9:Rars; Q9D0L8:Rnmt; Q9D0T1:Snu13; Q9D1B9:Mrpl28; Q9D1I6:Mrpl14; Q9D1M0:Sec13; Q9D1N9:Mrpl21; Q9D1R9:Rpl34; Q9D338:Mrpl19; Q9D6Z1:Nop56; Q9D7N3:Mrps9; Q9D7N6:Mrpl30; Q9D824:Fip1l1; Q9D8P4:Mrpl17; Q9DB15:Mrpl12; Q9DBR1:Xrn2; Q9DBY8:Nvl; Q9DC71:Mrps15; Q9DCI9:Mrpl32; Q9DCU6:Mrpl4; Q9EPU0:Upf1; Q9EPU4:Cpsf1; Q9ERU9:Ranbp2; Q9JIH2:Nup50; Q9JJT0:Rcl1; Q9QZD9:Eif3i; Q9QZV9:Nxt1; Q9Z0W3:Nup160; Q9Z1N5:Ddx39b
Translation	Genetic Information Processing	DEG	6	7.69	O35972:Mrpl23; P62141:Ppp1cb; Q6ZWY3:Rps27l; Q8BYM8:Cars2; Q8CFI5:Pars2; Q9D1B9:Mrpl28
Membrane transport	Environmental Information Processing	ALL	3	0.35	B2RX12:Abcc3; Q61102:Abcb7; Q9JI39:Abcb10
Signal transduction	Environmental Information Processing	ALL	115	13.55	A2A863:Itgb4; G3X9J0:Sipa1l3; G5E829:Atp2b1; O08528:Hk2; O09005:Degs1; O54890:Itgb3; O55143:Atp2a2; O70572:Smpd2; O88712:Ctbp1; P02463:Col4a1; P08752:Gnai2; P09055:Itgb1; P09411:Pgk1; P0DP28:Calm3; P10852:Slc3a2; P11881:Itpr1; P12382:Pfkl; P13011:Scd2; P15066:Jund; P15208:Insr; P21550:Eno3; P25799:Nfkb1; P26039:Tln1; P28862:Mmp3; P34152:Ptk2; P35235:Ptpn11; P46938:Yap1; P48962:Slc25a4; P49443:Ppm1a; P50516:Atp6v1a; P50518:Atp6v1e1; P51943:Ccna2; P60521:Gabarapl2; P60766:Cdc42; P62071:Rras2; P62137:Ppp1ca; P62141:Ppp1cb; P62715:Ppp2cb; P62814:Atp6v1b2; P62835:Rap1a; P62869:Elob; P62878:Rbx1; P63085:Mapk1; P63094:Gnas; P63101:Ywhaz; P63213:Gng2; P63280:Ube2i; P68181:Prkacb; P68510:Ywhah; P70227:Itpr3; P70302:Stim1; P70460:Vasp; P70677:Casp3; P97287:Mcl1; Q03145:Epha2; Q05769:Ptgs2; Q06138:Cab39; Q06180:Ptpn2; Q2TBE6:Pi4k2a; Q3UMR5:Mcu; Q3UYH7:Adrbk2; Q5SWU9:Acaca; Q60930:Vdac2; Q61001:Lama5; Q61081:Cdc37; Q61301:Ctnna2; Q61411:Hras; Q62074:Prkci; Q62469:Itga2; Q62470:Itga3; Q63844:Mapk3; Q6PHZ2:Camk2d; Q76MZ3:Ppp2r1a; Q7TNP2:Ppp2r1b; Q80U72:Scrib; Q80V26:Impad1; Q80X90:Flnb; Q80X95:Rraga; Q80Y17:Llgl1; Q8BH04:Pck2; Q8BHJ5:Tbl1xr1; Q8BVP5:Csnk1g2; Q8C0T5:Sipa1l1; Q8CBQ5:Pi4k2b; Q8CG19:Ltbp1; Q8CIN4:Pak2; Q8K2J0:Plcd3; Q8K4X7:Agpat4; Q8R2U0:Seh1l; Q8VDN2:Atp1a1; Q8VHX6:Flnc; Q924Z4:Cers2; Q99K70:Rragc; Q99KR7:Ppif; Q99M51:Nck1; Q9CQ22:Lamtor1; Q9CQD1:Rab5a; Q9CXP8:Gng10; Q9CXW3:Cacybp; Q9CZX7:Pip4p2; Q9D051:Pdhb; Q9D1K2:Atp6v1f; Q9D1L9:Lamtor5; Q9D1M0:Sec13; Q9D4H8:Cul2; Q9D517:Agpat3; Q9DAX2:Plpp2; Q9DBR7:Ppp1r12a; Q9EP69:Sacm1l; Q9JHS3:Lamtor2; Q9JIW9:Ralb; Q9JLV5:Cul3; Q9QXE7:Tbl1x; Q9QZQ1:Afdn; Q9R0H0:Acox1
Signal transduction	Environmental Information Processing	DEG	18	23.08	P21550:Eno3; P28862:Mmp3; P49443:Ppm1a; P51943:Ccna2; P60766:Cdc42; P62141:Ppp1cb; P63213:Gng2; P68181:Prkacb; Q3UMR5:Mcu; Q3UYH7:Adrbk2; Q61301:Ctnna2; Q63844:Mapk3; Q6PHZ2:Camk2d; Q80V26:Impad1; Q8BHJ5:Tbl1xr1; Q8BVP5:Csnk1g2; Q9CXP8:Gng10; Q9JHS3:Lamtor2
Signaling molecules and interaction	Environmental Information Processing	ALL	13	1.53	A2A863:Itgb4; O54890:Itgb3; O88792:F11r; P01027:C3; P02463:Col4a1; P09055:Itgb1; P32507:Nectin2; Q05793:Hspg2; Q3TEW6:Mpzl1; Q61001:Lama5; Q62469:Itga2; Q62470:Itga3; Q9QZM4:Tnfrsf10b
Cell growth and death	Cellular Processes	ALL	58	6.83	A2A6Q5:Cdc27; O08529:Capn2; O35638:Stag2; O88554:Parp2; P05213:Tuba1b; P09528:Fth1; P0DP28:Calm3; P10852:Slc3a2; P11881:Itpr1; P14733:Lmnb1; P21619:Lmnb2; P25799:Nfkb1; P26443:Glud1; P27661:H2afx; P48678:Lmna; P48962:Slc25a4; P49282:Slc11a2; P49718:Mcm5; P51943:Ccna2; P54731:Faf1; P60335:Pcbp1; P62071:Rras2; P62137:Ppp1ca; P62141:Ppp1cb; P62715:Ppp2cb; P62878:Rbx1; P63085:Mapk1; P63101:Ywhaz; P68181:Prkacb; P68368:Tuba4a; P68510:Ywhah; P70227:Itpr3; P70677:Casp3; P97287:Mcl1; P97310:Mcm2; Q3UMR5:Mcu; Q60930:Vdac2; Q60972:Rbbp4; Q61411:Hras; Q61990:Pcbp2; Q63844:Mapk3; Q64337:Sqstm1; Q6PHZ2:Camk2d; Q6ZWX6:Eif2s1; Q76MZ3:Ppp2r1a; Q7TNP2:Ppp2r1b; Q8BUE4:Aifm2; Q91V01:Lpcat3; Q921W0:Chmp1a; Q9CR16:Ppid; Q9CU62:Smc1a; Q9CZW4:Acsl3; Q9D7S9:Chmp5; Q9D8B3:Chmp4b; Q9QZM4:Tnfrsf10b; Q9QZQ8:H2afy; Q9WTX8:Mad1l1; Q9WUV0:Orc5
Cell growth and death	Cellular Processes	DEG	9	11.54	A2A6Q5:Cdc27; P27661:H2afx; P51943:Ccna2; P62141:Ppp1cb; P68181:Prkacb; Q3UMR5:Mcu; Q63844:Mapk3; Q6PHZ2:Camk2d; Q9QZQ8:H2afy
Cell motility	Cellular Processes	ALL	32	3.77	A2A863:Itgb4; O54890:Itgb3; P09055:Itgb1; P26041:Msn; P26043:Rdx; P28660:Nckap1; P34152:Ptk2; P60766:Cdc42; P62071:Rras2; P62137:Ppp1ca; P62141:Ppp1cb; P63085:Mapk1; Q3THE2:Myl12b; Q61210:Arhgef1; Q61411:Hras; Q61879:Myh10; Q62469:Itga2; Q62470:Itga3; Q63844:Mapk3; Q64727:Vcl; Q7TMB8:Cyfip1; Q7TPR4:Actn1; Q8BG95:Ppp1r12b; Q8BKX1:Baiap2; Q8CIN4:Pak2; Q8VDD5:Myh9; Q91VR8:Brk1; Q9CVB6:Arpc2; Q9D898:Arpc5l; Q9DBR7:Ppp1r12a; Q9JKF1:Iqgap1; Q9JM76:Arpc3
Cell motility	Cellular Processes	DEG	5	6.41	P60766:Cdc42; P62141:Ppp1cb; Q63844:Mapk3; Q91VR8:Brk1; Q9D898:Arpc5l
Cellular community - eukaryotes	Cellular Processes	ALL	61	7.18	A2A863:Itgb4; O08529:Capn2; O54890:Itgb3; O55222:Ilk; O88792:F11r; P02463:Col4a1; P05213:Tuba1b; P08752:Gnai2; P09055:Itgb1; P11881:Itpr1; P15208:Insr; P23242:Gja1; P23798:Pcgf2; P26039:Tln1; P26041:Msn; P26043:Rdx; P32507:Nectin2; P34152:Ptk2; P60766:Cdc42; P62137:Ppp1ca; P62141:Ppp1cb; P62715:Ppp2cb; P62835:Rap1a; P63085:Mapk1; P63094:Gnas; P68181:Prkacb; P68368:Tuba4a; P68372:Tubb4b; P70227:Itpr3; P70460:Vasp; P99024:Tubb5; Q3THE2:Myl12b; Q60598:Cttn; Q61001:Lama5; Q61301:Ctnna2; Q61411:Hras; Q61879:Myh10; Q62074:Prkci; Q62417:Sorbs1; Q62469:Itga2; Q62470:Itga3; Q63844:Mapk3; Q64727:Vcl; Q6PR54:Rif1; Q76MZ3:Ppp2r1a; Q7TNP2:Ppp2r1b; Q7TPR4:Actn1; Q80U72:Scrib; Q80X90:Flnb; Q80Y17:Llgl1; Q8BG95:Ppp1r12b; Q8BKX1:Baiap2; Q8BU31:Rap2c; Q8CIN4:Pak2; Q8VDD5:Myh9; Q8VHX6:Flnc; Q9DBR7:Ppp1r12a; Q9JKB3:Ybx3; Q9JKF1:Iqgap1; Q9QZQ1:Afdn; Q9WVC3:Cav2
Cellular community - eukaryotes	Cellular Processes	DEG	6	7.69	P23798:Pcgf2; P60766:Cdc42; P62141:Ppp1cb; P68181:Prkacb; Q61301:Ctnna2; Q63844:Mapk3
Transport and catabolism	Cellular Processes	ALL	90	10.6	O08547:Sec22b; O35114:Scarb2; O35459:Ech1; O54890:Itgb3; O70579:Slc25a17; P01027:C3; P05213:Tuba1b; P08228:Sod1; P09055:Itgb1; P11881:Itpr1; P15920:Atp6v0a2; P17426:Ap2a1; P22892:Ap1g1; P32020:Scp2; P35700:Prdx1; P40336:Vps26a; P49282:Slc11a2; P50428:Arsa; P50516:Atp6v1a; P50518:Atp6v1e1; P51863:Atp6v0d1; P54071:Idh2; P60521:Gabarapl2; P60766:Cdc42; P61967:Ap1s1; P62071:Rras2; P62715:Ppp2cb; P62814:Atp6v1b2; P63024:Vamp3; P63085:Mapk1; P68181:Prkacb; P68368:Tuba4a; P68372:Tubb4b; P70699:Gaa; P84084:Arf5; P99024:Tubb5; Q3UYH7:Adrbk2; Q60902:Eps15l1; Q61009:Scarb1; Q61411:Hras; Q61768:Kif5b; Q62074:Prkci; Q62469:Itga2; Q63844:Mapk3; Q64337:Sqstm1; Q68FD5:Cltc; Q6P8X1:Snx6; Q6ZWX6:Eif2s1; Q80X95:Rraga; Q811U4:Mfn1; Q8BG51:Rhot1; Q8BH64:Ehd2; Q8BL66:Eea1; Q8C0E2:Vps26b; Q8C0I1:Agps; Q8JZN7:Rhot2; Q8R0H9:Gga1; Q8VDS8:Stx18; Q921E2:Rab31; Q921H8:Acaa1a; Q921W0:Chmp1a; Q922J9:Far1; Q99K28:Arfgap2; Q99K70:Rragc; Q99KU0:Vmp1; Q9CQ92:Fis1; Q9CQD1:Rab5a; Q9CQS8:Sec61b; Q9CR26:Vta1; Q9CVB6:Arpc2; Q9CZW4:Acsl3; Q9D0I4:Stx17; Q9D0K1:Pex13; Q9D1K2:Atp6v1f; Q9D7S9:Chmp5; Q9D898:Arpc5l; Q9D8B3:Chmp4b; Q9DBG3:Ap2b1; Q9DC50:Crot; Q9ER00:Stx12; Q9ERB0:Snap29; Q9JHU4:Dync1h1; Q9JK48:Sh3glb1; Q9JLR1:Sec61a2; Q9JM76:Arpc3; Q9R0A0:Pex14; Q9R0H0:Acox1; Q9WU78:Pdcd6ip; Q9WVC3:Cav2; Q9Z210:Pex11b
Transport and catabolism	Cellular Processes	DEG	14	17.95	O35114:Scarb2; P15920:Atp6v0a2; P22892:Ap1g1; P40336:Vps26a; P51863:Atp6v0d1; P60766:Cdc42; P68181:Prkacb; P84084:Arf5; Q3UYH7:Adrbk2; Q63844:Mapk3; Q8C0E2:Vps26b; Q9CR26:Vta1; Q9D898:Arpc5l; Q9ERB0:Snap29