Provider: Impact Journals, LLC TY - JOUR AU - Song, Xiao-Chun AU - Zhou, Xue-Hui AU - Cheng, Jing-Hui AU - Zhang, Wen-Hao AU - Shen, Xiao AU - Xu, Huan AU - Nie, Shuai AU - Xiao, Ji-Lai AU - Sun, Fang AU - Shu, Chang AU - Chen, Jiu-Dong AU - Tang, Yan AU - Wang, Xiang AU - Sun, Xin-Pei AU - Sun, Jia-Kui AU - Feng, Ping AU - Shi, Qian-Kun TI - The roles of inactivated vaccines in older patients with infection of Delta variant in Nanjing, China JO - Aging JA - Aging (Albany NY) VL - 14 IS - 10 PB - Impact Journals, LLC SN - 1945-4589 UR - https://doi.org/10.18632/aging.204085 DO - 10.18632/aging.204085 SP - 4211 EP - 4219 PY - AB - Background: The coronavirus disease 2019 (COVID-19) is spreading around the world. The COVID-19 vaccines may improve concerns about the pandemic. However, the roles of inactivated vaccines in older patients (aged ≥60 years) with infection of Delta variant were less studied. Methods: We classified the older patients with infection of Delta variant into three groups based on the vaccination status: no vaccination (group A, n = 113), one dose of vaccination (group B, n = 46), and two doses of vaccination (group C, n = 22). Two inactivated COVID-19 vaccines (BBIBP-CorV or CoronaVac) were evaluated in this study. The demographic data, laboratory parameters, and clinical severity were recorded. Results: A total of 181 older patients with infection of Delta variant were enrolled. 111 (61.3%) patients had one or more co-morbidities. The days of "turn negative" and hospital stay in Group C were lower than those in the other groups (P < 0.05). The incidences of multiple organ dysfunction syndrome (MODS), septic shock, acute respiratory distress syndrome (ARDS), acute kidney injury, and cardiac injury in Group A were higher than those in the other groups (P < 0.05). The MV-free days and ICU-free days during 28 days in Group A were also lower than those in the other groups (P < 0.05). In patients with co-morbidities, vaccinated cases had lower incidences of MODS (P = 0.015), septic shock (P = 0.015), and ARDS (P = 0.008). Conclusions: The inactivated COVID-19 vaccines were effective in improving the clinical severity of older patients with infection of Delta variant. ER -