Provider: Impact Journals, LLC
TY  - JOUR
AU  - Song, Xiao-Chun 
AU  - Zhou, Xue-Hui 
AU  - Cheng, Jing-Hui 
AU  - Zhang, Wen-Hao 
AU  - Shen, Xiao 
AU  - Xu, Huan 
AU  - Nie, Shuai 
AU  - Xiao, Ji-Lai 
AU  - Sun, Fang 
AU  - Shu, Chang 
AU  - Chen, Jiu-Dong 
AU  - Tang, Yan 
AU  - Wang, Xiang 
AU  - Sun, Xin-Pei 
AU  - Sun, Jia-Kui 
AU  - Feng, Ping 
AU  - Shi, Qian-Kun 
TI  - The roles of inactivated vaccines in older patients with infection of Delta variant in Nanjing, China
JO  - Aging
JA  - Aging (Albany NY)
VL  - 14
IS  - 10
PB  - Impact Journals, LLC
SN  - 1945-4589
UR  - https://doi.org/10.18632/aging.204085
DO  - 10.18632/aging.204085
SP  - 4211
EP  - 4219
PY  - 
AB  - Background: The coronavirus disease 2019 (COVID-19) is spreading around the world. The COVID-19 vaccines may improve concerns about the pandemic. However, the roles of inactivated vaccines in older patients (aged ≥60 years) with infection of Delta variant were less studied.
Methods: We classified the older patients with infection of Delta variant into three groups based on the vaccination status: no vaccination (group A, n = 113), one dose of vaccination (group B, n = 46), and two doses of vaccination (group C, n = 22). Two inactivated COVID-19 vaccines (BBIBP-CorV or CoronaVac) were evaluated in this study. The demographic data, laboratory parameters, and clinical severity were recorded.
Results: A total of 181 older patients with infection of Delta variant were enrolled. 111 (61.3%) patients had one or more co-morbidities. The days of "turn negative" and hospital stay in Group C were lower than those in the other groups (P < 0.05). The incidences of multiple organ dysfunction syndrome (MODS), septic shock, acute respiratory distress syndrome (ARDS), acute kidney injury, and cardiac injury in Group A were higher than those in the other groups (P < 0.05). The MV-free days and ICU-free days during 28 days in Group A were also lower than those in the other groups (P < 0.05). In patients with co-morbidities, vaccinated cases had lower incidences of MODS (P = 0.015), septic shock (P = 0.015), and ARDS (P = 0.008).
Conclusions: The inactivated COVID-19 vaccines were effective in improving the clinical severity of older patients with infection of Delta variant.
ER  -