%A Xu, Ke 
%A Hu, Biwen 
%A Ding, Xuhui 
%A Zhan, Zhengyu 
%D 2023
%T Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng
%! Alleviation of D-gal-induced senile liver injury by Rg3, a signature component of red ginseng
%K Rg3, red ginseng, D-gal, liver injury
%X To investigate the mechanism by which ginsenoside Rg3 regulates oxidative stress (OS) and inflammation through NF/KB pathway to delay mouse liver injury.
This work randomized Balbc mice as four groups: Normal, D-gal, Rg3-L, Rg3-H. Paraffin-embedded liver tissue sections were prepared, later, BAX/BCL-2 protein expression was observed by HE, Sirius red, TUNEL and immunofluorescence to detect apoptotic injury and α-SMA/TGF-β protein expression to detect fibrosis, and liver inflammation-related protein NF-KB was detected.
HE and TUNEL staining showed that Rg3 reduced necrotic cells and fibrosis in liver-injured mice, Rg3 increased anti-inflammatory cytokine IL-18 and reduced TNF-α, IL-1β and IL-6 expression. Conclusion: Ginsenoside Rg3 can effectively antagonize D-gal’s role in mouse liver injury, and its mechanism may be associated with regulating inflammatory pathway by Rg.
%U https://doi.org/10.18632/aging.204819
%J Aging
%0 Journal Article
%V 15
%N 14
%P 6749-6756
%R 10.18632/aging.204819
%@ 1945-4589