ࡱ > C B T8 \ p Velavanan B a = = Z "8 X@ " 1 C a l i b r i 1 I{~1 I{~1 I{~1 I{~1 I{~1 C a l i b r i 1 * h 6
C a l i b r i L i g h t 1 , 6 C a l i b r i 1 6 C a l i b r i 1 6 C a l i b r i 1 C a l i b r i 1 C a l i b r i 1 C a l i b r i 1 4 C a l i b r i 1 C a l i b r i 1 C a l i b r i 1
C a l i b r i 1 4 C a l i b r i 1 < C a l i b r i 1 ? C a l i b r i 1 > C a l i b r i 1 C a l i b r i 1 . T i m e s N e w R o m a n 1 . T i m e s N e w R o m a n "$"#,##0_);\("$"#,##0\) ! "$"#,##0_);[Red]\("$"#,##0\) " "$"#,##0.00_);\("$"#,##0.00\) ' " "$"#,##0.00_);[Red]\("$"#,##0.00\) 7 * 2 _("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_) . ) ) _(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_) ? , : _("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_) 6 + 1 _(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_) ""#,##0;""\-#,##0 ""#,##0;[Red]""\-#,##0 ""#,##0.00;""\-#,##0.00 # ""#,##0.00;[Red]""\-#,##0.00 7 2 _ ""* #,##0_ ;_ ""* \-#,##0_ ;_ ""* "-"_ ;_ @_ . ) _ * #,##0_ ;_ * \-#,##0_ ;_ * "-"_ ;_ @_ ? : _ ""* #,##0.00_ ;_ ""* \-#,##0.00_ ;_ ""* "-"??_ ;_ @_ 6 1 _ * #,##0.00_ ;_ * \-#,##0.00_ ;_ * "-"??_ ;_ @_ \$#,##0_);\(\$#,##0\) \$#,##0_);[Red]\(\$#,##0\) \$#,##0.00_);\(\$#,##0.00\) % \$#,##0.00_);[Red]\(\$#,##0.00\) ff
P
P ` a > X X x @ @ 8 @ @ 8 x x 8 x @ X 8 @ @ | | K 7\.}- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }- }
.00\)_ * }A }
.00\)_ * ef ;_ @_ }A }
.00\)_ * ef ;_ @_ }A }
.00\)_ * ef ;_ @_ }A }
.00\)_ * ef ;_ @_ }A }
.00\)_ * ef ;_ @_ }A }
.00\)_ * ef ;_ @_ }A }
.00\)_ * L ;_ @_ }A }
.00\)_ * L ;_ @_ }A }
.00\)_ * L ;_ @_ }A }
.00\)_ * L ;_ @_ }A }
.00\)_ * L ;_ @_ }A }
.00\)_ * L ;_ @_ }A }
.00\)_ * 23 ;_ @_ }A }
.00\)_ * 23 ;_ @_ }A }
.00\)_ * 23 ;_ @_ }A }
.00\)_ * 23 ;_ @_ }A }
.00\)_ * 23 ;_ @_ }A } !
.00\)_ * 23 ;_ @_ }- } :
.00\)_ * }- } ;
.00\)_ * }A } 1
.00\)_ * ;_ @_ }A } 2
.00\)_ * ? ;_ @_ }A } 3
.00\)_ * 23 ;_ @_ }- } 4
.00\)_ * }A } (
.00\)_ * ;_ @_ }A } 0
a .00\)_ * ;_ @_ }U } <
.00\)_ * ;_ @_ }- } -
.00\)_ * }- } .
.00\)_ * } } )
} .00\)_ * ;_ @_
} } *
.00\)_ * ;_ @_ ??? ??? ???
??? }- } /
.00\)_ * }- } =
.00\)_ * }A } 6
} .00\)_ * ;_ @_ }- } +
.00\)_ * }- } ,
.00\)_ * }A } 7
W .00\)_ * ;_ @_ } } 9
???.00\)_ * ;_ @_ ??? ??? ???
??? } } 5
??v.00\)_ * ̙;_ @_
}A } "
.00\)_ * ;_ @_ }A } #
.00\)_ * ;_ @_ }A } $
.00\)_ * ;_ @_ }A } %
.00\)_ * ;_ @_ }A } &
.00\)_ * ;_ @_ }A } '
.00\)_ * ;_ @_ } } 8
.00\)_ * ;_ @_
}< } >
.00\)_ * ;_ }< } ?
.00\)_ * ;_ }( } @
.00\)_ *}< } A
.00\)_ * ;_ }( } B
.00\)_ *}( } C
.00\)_ *}< } D
.00\)_ * ;_ }< } E
.00\)_ * ;_ }( } F
.00\)_ *}< } G
.00\)_ * ;_ }< } H
.00\)_ * ;_ }( } I
.00\)_ *}( } J
.00\)_ *
20% - Accent1M
2 0 % - A c c e n t 1 ef %
20% - Accent2M "
2 0 % - A c c e n t 2 ef %
20% - Accent3M &
2 0 % - A c c e n t 3 ef %
20% - Accent4M *
2 0 % - A c c e n t 4 ef %
20% - Accent5M .
2 0 % - A c c e n t 5 ef %
20% - Accent6M 2
2 0 % - A c c e n t 6 ef %
40% - Accent1M
4 0 % - A c c e n t 1 L %
40% - Accent2M #
4 0 % - A c c e n t 2 L˭ %
40% - Accent3M '
4 0 % - A c c e n t 3 L %
40% - Accent4M +
4 0 % - A c c e n t 4 L %
40% - Accent5M /
4 0 % - A c c e n t 5 L %
40% - Accent6M 3
4 0 % - A c c e n t 6 L %
60% - Accent1M
6 0 % - A c c e n t 1 23 %
60% - Accent2M $
6 0 % - A c c e n t 2 23 %
60% - Accent3M (
6 0 % - A c c e n t 3 23 %
60% - Accent4M ,
6 0 % - A c c e n t 4 23f %
60% - Accent5M 0
6 0 % - A c c e n t 5 23 % !
60% - Accent6M 4
6 0 % - A c c e n t 6 23Ў % " Accent1A A c c e n t 1 Dr % # Accent2A ! A c c e n t 2 }1 % $ Accent3A % A c c e n t 3 % % Accent4A ) A c c e n t 4 % & Accent5A - A c c e n t 5 [ % ' Accent6A 1 A c c e n t 6 pG % ( Bad9 B a d % ) Calculation C a l c u l a t i o n } % *
Check Cell
C h e c k C e l l % ??? ??? ??? ??? + C o m m a ,( C o m m a [ 0 ] -& C u r r e n c y .. C u r r e n c y [ 0 ] / Explanatory TextG 5 E x p l a n a t o r y T e x t % 0 Good; G o o d a % 1 Heading 1G H e a d i n g 1 DTj% Dr 2 Heading 2G H e a d i n g 2 DTj% ? 3 Heading 3G H e a d i n g 3 DTj% 23 4 Heading 49 H e a d i n g 4 DTj%
5 Inputu I n p u t ̙ ??v% 6 Linked CellK L i n k e d C e l l } % 7 NeutralA N e u t r a l W % 3 N o r m a l % 8 Noteb
N o t e 9 Outputw O u t p u t ???% ??? ??? ??? ??? :$ P e r c e n t
; Title1 T i t l e DTj%
< TotalM T o t a l % Dr Dr = Warning Text? W a r n i n g T e x t % X T a b l e S t y l e M e d i u m 2 P i v o t S t y l e L i g h t 1 6 ` 3P Sheet1 S
exposures 7 outcome 7 method 7
number SNP 7 Beta 7 lower CI 7 upper CI 7 Standard error 7 OR 7 OR lower CI 7 OR upper CI 7 P value 7 DKK1 7 CAD 7 MR Egger 7 Inverse variance weighted 7 Maximum likelihood 7
Simple median 7 Weighted median 7 Penalised weighted median 7 Simple mode 7
Weighted mode 7 IS 7 x DKK1, dickkopf-1; CAD, coronary artery disease; IS, ischemic stroke; OR, odds ratio; SNP, single nucleotide polymorphism 7 a Supplementary Table 3. Two sample Mendelian randomization estimations results with eight methods. 0.111539292144876 0.083508443816135 0.0860548382690975 0.0170562446779767 0.0367440623473944 0.0317123759597467 0.00144606443389528 0.0202908648814402 0.049597112938075 0.091249071204544 0.0946203523538643 0.0630630630630631 0.0581086566362789 0.0586175230326046 0.0434403453193332 -0.0229170243619893 0.0234362955246142 0.027621118692638 -0.0751088925967662 -0.0506720167769695 -0.0548217457431585 -0.155875004370098 -0.095639304061041 -0.121266020028949 0.00431752453012954 0.0111726249396038 -0.0647847948083183 -0.0607116758082766 -0.0588164965241332 -0.171735796285666 -0.122995740779522 0.245995608651742 0.143580592107656 0.144488557845557 0.10922138195272 0.124160141471758 0.118246497662652 0.158767133237889 0.136221033823921 0.220460245905099 0.178180617878958 0.178068079768125 0.190910920934444 0.176928989080834 0.176051542589342 0.258616486924333 0.209876431418188 0.0686001614830947 0.0306490552507759 0.0298131222328875 0.0470230292218076 0.0446000403695734 0.044150062093319 0.0802658514306088 0.0591480453788169 0.0871750678403185 0.0443528299359257 0.0425753711297247 0.0652284989139701 0.060622618594161 0.0599153161003764 0.109783745716836 0.0849163704585996 1.11799767166901 1.08709439447931 1.08986609303651 1.01720253294523 1.03742747010594 1.03222057115336 1.00144711048923 1.02049812392848 1.05084763816136 1.09554183920503 1.09924145146837 1.06509400520386 1.059830147033 1.06036959622278 1.04439768924301 1.0237130835644 1.02800611832434 1.0043268584675 1.01123527180622 0.97734357611567 0.927642467431398 0.950590397111315 0.946653877998122 0.855666138214805 0.908791754453391 0.885798288161345 0.937269146861366 0.941094540985644 0.942879774999065 0.842201656582621 0.884267428842741 1.27889395746066 1.15439984257463 1.15544847406822 1.11540925448922 1.13219716820302 1.12552151559905 1.17206497992265 1.14593515603355 1.24665036429623 1.19504114754051 1.1949066674346 1.21035163028682 1.19354633529547 1.19249952157981 1.29513700759283 1.23352562552671 0.121343318486178 0.00643665323983873 0.00389583436041278 0.716813239423381 0.410020727776718 0.472580898340913 0.985813985855878 0.73532568735447 0.575433951817338 0.0396530553105881 0.0262549412298009 0.333642872258291 0.337795088814787 0.327906418108531 0.696144733313749 0.614051228395536 5 6 7 8 9 =: 2 : ; 3< ( < z= o > > M? B
?
@ | A A ZB O
c c c PK ! [Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;r ØJB+$G]7O٭V6{|Kۡ%C 7Aԅcۅ8T XadwuƝl mM=\('P^Ke#b c{lcw K 6CqKzV"B$L\!Ԗov xuF]n# ]L-7Bc". $C΄M\KHt)Z,Kf~߅
.D6K2rA&5B%.lġ-F;`e!(^[>܇jRDsG,oafogBʼn3;J ):F ,|BUƮĺ\U1sb!J>3Aq2{u-rRO#G`
|q:e_#j=ջԵp[;3E %s@a7e.Wdrf||Fv<'Zz3$v O}|aQSO &!|Tm X#-q&?%2(b:^enh
ғbQjU :R]wz6Ч3J<$ c65lQ9I $.źu~@-
|z/@0SYtu0/3˜ie س #.ݞ]jgEH7 D_٩VB㼱^CjS rcqX|mY)h ZR?c%;B}B4/}"%B6S뢓VH=JƺhnU( ,u(+ 9 d< 4n(OPZἫ/Vl cG +Wʁ"A17טe|s(]G4 ѴussB% ]
)ƋeX;f
>
? ~
? 4@
H
H (
H 8
H H
H X
H k
H w
H
>
>
@ ~
@ 4@
I
I )
I 9
I I
I Y
I g
I x
I
>
>
? ~
? 4@
H
H *
H :
H J
H Z
H h
H y
H
>
>
@ ~
@ 4@
I
I +
I ;
I K
I [
I l
I z
I
>
>
? ~
? 4@
H
H ,
H <
H L
H \
H m
H {
H
>
>
@ ~
@ 4@
I
I -
I =
I M
I ]
I n
I |
I
>
>
? ~
? 4@
H
H .
H >
H N
H ^
H o
H }
H
A
A
B ~
B 4@
J
J /
J ?
J O
J _
J p
J ~
J
>
>
? ~
? 7@
H !
H 0
H @
H P
H `
H q
H
H
>
>
@ ~
@ 7@
I "
I 1
I A
I Q
I a
I i
I
I
>
>
? ~
? 7@
H #
H 2
H B
H R
H b
H j
H
H
>
>
@ ~
@ 7@
I $
I 3
I C
I S
I c
I r
I
I
>
>
? ~
? 7@
H %
H 4
H D
H T
H d
H s
H
H
>
>
@ ~
@ 7@
I &
I 5
I E
I U
I e
I t
I
I
>
>
? ~
? 7@
H '
H 6
H F
H V
H f
H u
H
H
A
>
B ~
@ 7@
I '
I 7
I G
I W
I f
I v
I
I
G G G G G G G G G G G G *
h. > @ U G B m 7
; B A'
?B A'
; B A'
?B A'
; B A'
?B A'
; B A'
?B A' {U { & ; rf|| {+ { {U { & ; rf|| {+ { {U { & ; rf|| {+ { {U {
& ; rf|| {+ {
g g D
Oh +'0 @ H X l
lenovo Saravanan Microsoft Excel @ w8@ km ՜. +,0 P X d l t |
Sheet1 Worksheets
! " # $ % & ' ( ) * + , - . / 0 1 3 4 5 6 7 8 9 ; < = > ? @ A R o o t E n t r y F yi W o r k b o o k ac S u m m a r y I n f o r m a t i o n ( 2 D o c u m e n t S u m m a r y I n f o r m a t i o n 8 :