ࡱ> DC T8\pVelavanan Ba==Z "8X@"1Calibri1I{~1I{~1I{~1I{~1I{~1Calibri1*h6 Calibri Light1,6Calibri16Calibri16Calibri1Calibri1Calibri1Calibri14Calibri1 Calibri1Calibri1 Calibri14Calibri1<Calibri1?Calibri1>Calibri1 Calibri1.Times New Roman1.Times New Roman"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_)""#,##0;""\-#,##0""#,##0;[Red]""\-#,##0""#,##0.00;""\-#,##0.00#""#,##0.00;[Red]""\-#,##0.0072_ ""* #,##0_ ;_ ""* \-#,##0_ ;_ ""* "-"_ ;_ @_ .)_ * #,##0_ ;_ * \-#,##0_ ;_ * "-"_ ;_ @_ ?:_ ""* #,##0.00_ ;_ ""* \-#,##0.00_ ;_ ""* "-"??_ ;_ @_ 61_ * #,##0.00_ ;_ * \-#,##0.00_ ;_ * "-"??_ ;_ @_ \$#,##0_);\(\$#,##0\)\$#,##0_);[Red]\(\$#,##0\) \$#,##0.00_);\(\$#,##0.00\)% \$#,##0.00_);[Red]\(\$#,##0.00\)                                            ff         P  P        `         a>    X X x  8  8"@  x"@  x"@  8 x  8   X    8   8  8  x ||Pn3M}-} .00\)_ *}-} .00\)_ *}-} .00\)_ *}-} .00\)_ *}-} .00\)_ *}-} .00\)_ *}-} .00\)_ *}-} .00\)_ *}-} .00\)_ *}-}  .00\)_ *}-}  .00\)_ *}-}  .00\)_ *}-}  .00\)_ *}-}  .00\)_ *}-} .00\)_ *}-} .00\)_ *}A} .00\)_ *ef;_ @_ }A} .00\)_ *ef;_ @_ }A} .00\)_ *ef;_ @_ }A} .00\)_ *ef;_ @_ }A} .00\)_ *ef;_ @_ }A} .00\)_ *ef ;_ @_ }A} .00\)_ *L;_ @_ }A} .00\)_ *L;_ @_ }A} .00\)_ *L;_ @_ }A} .00\)_ *L;_ @_ }A} .00\)_ *L;_ @_ }A} .00\)_ *L ;_ @_ }A} .00\)_ *23;_ @_ }A} .00\)_ *23;_ @_ }A} .00\)_ *23;_ @_ }A} .00\)_ *23;_ @_ }A}  .00\)_ *23;_ @_ }A}! .00\)_ *23 ;_ @_ }A}" .00\)_ *;_ @_ }A}# .00\)_ *;_ @_ }A}$ .00\)_ *;_ @_ }A}% .00\)_ *;_ @_ }A}& .00\)_ *;_ @_ }A}' .00\)_ * ;_ @_ }A}( .00\)_ *;_ @_ }}) }.00\)_ *;_ @_    }}* .00\)_ *;_ @_ ??? ??? ??? ???}-}+ .00\)_ *}-}, .00\)_ *}-}- .00\)_ *}-}. .00\)_ *}-}/ .00\)_ *}A}0 a.00\)_ *;_ @_ }A}1 .00\)_ *;_ @_ }A}2 .00\)_ *?;_ @_ }A}3 .00\)_ *23;_ @_ }-}4 .00\)_ *}}5 ??v.00\)_ *̙;_ @_    }A}6 }.00\)_ *;_ @_ }A}7 W.00\)_ *;_ @_ }}8 .00\)_ *;_ @_    }}9 ???.00\)_ *;_ @_ ??? ??? ??? ???}-}: .00\)_ *}-}; .00\)_ *}U}< .00\)_ *;_ @_  }-}= .00\)_ *}(}> .00\)_ *}(}? .00\)_ *}<}@ .00\)_ *;_ }<}A .00\)_ *;_ }<}B .00\)_ *;_ }(}C .00\)_ *}(}D .00\)_ *}<}E .00\)_ *;_ }<}F .00\)_ *;_ }(}G .00\)_ *}<}H .00\)_ *;_ }(}I .00\)_ *}<}J .00\)_ *;_ }(}K .00\)_ *}(}L .00\)_ *}(}M .00\)_ *}(}N .00\)_ *}<}O .00\)_ *;_      20% - Accent1M 20% - Accent1 ef % 20% - Accent2M" 20% - Accent2 ef % 20% - Accent3M& 20% - Accent3 ef % 20% - Accent4M* 20% - Accent4 ef % 20% - Accent5M. 20% - Accent5 ef % 20% - Accent6M2 20% - Accent6  ef % 40% - Accent1M 40% - Accent1 L % 40% - Accent2M# 40% - Accent2 L˭ % 40% - Accent3M' 40% - Accent3 L % 40% - Accent4M+ 40% - Accent4 L % 40% - Accent5M/ 40% - Accent5 L % 40% - Accent6M3 40% - Accent6  L % 60% - Accent1M 60% - Accent1 23 % 60% - Accent2M$ 60% - Accent2 23 % 60% - Accent3M( 60% - Accent3 23 % 60% - Accent4M, 60% - Accent4 23f % 60% - Accent5M0 60% - Accent5 23 %! 60% - Accent6M4 60% - Accent6  23Ў % "Accent1AAccent1 Dr % #Accent2A!Accent2 }1 % $Accent3A%Accent3  % %Accent4A)Accent4  % &Accent5A-Accent5 [ % 'Accent6A1Accent6  pG %(Bad9Bad  %) Calculation Calculation  }% * Check Cell Check Cell  %????????? ???+ Comma,( Comma [0]-&Currency.. Currency [0]/Explanatory TextG5Explanatory Text % 0Good;Good  a%1 Heading 1G Heading 1 DTj%Dr2 Heading 2G Heading 2 DTj%?3 Heading 3G Heading 3 DTj%234 Heading 49 Heading 4 DTj% 5InputuInput ̙ ??v% 6 Linked CellK Linked Cell }% 7NeutralANeutral  W%3Normal % 8Noteb Note   9OutputwOutput  ???%????????? ???:$Percent ;Title1Title DTj% <TotalMTotal %DrDr= Warning Text? Warning Text %XTableStyleMedium2PivotStyleLight16`!QSheet1SW exposures 7outcome 7method 7 number SNP 7Beta 7lower CI 7upper CI 7Standard error 7OR 7 OR lower CI 7 OR upper CI 7P value 7CAD 7DKK1 7MR EggerInverse variance weightedMaximum likelihood Simple medianWeighted medianPenalised weighted median Simple mode Weighted modeIS 7DDKK1, dickkopf-1; CAD, coronary artery disease; IS, ischemic stroke. 7-0.0164764957620807-0.0148455489274186-0.0149597382602991-0.0212044597336626-0.00228276056215832-0.00028884078282741-0.0124665295650165-0.00862333346930761-0.00944958818152569-0.0484866294446077-0.0527864491317959-0.0559256744996441-0.117260640853551-0.09012130304190490.01730563921762570.269413974625982-0.100701360105632-0.050858417721191-0.0513371096454418-0.0767329476521125-0.0598911080406283-0.0583177833852601-0.155024829849149-0.075543591060594-0.108082739855385-0.0865784334826688-0.165971904171473-0.167632346613552-0.165176889807793-0.322468624413947-0.2699994258956880.02705996460869890.06774836858147030.04297186956303620.9836584992623620.9042030236643230.02116731986635370.01837391264988390.9852641029493410.9504132226769790.02141763312484370.01855988335976670.9851516027219990.9499583764168840.03432402818478730.02833086118288260.97901877418690.9261371476845490.05532558691631160.02939201401962750.9977198429542890.9418670897532470.05774010181960530.02960660336858810.9997112009276560.9433501188048040.1300917707191160.07273382667557790.9876108557056270.8563939130879440.1101548694958450.04737205626439780.9272393103080640.5117679846432650.1236500051108590.09083607291676960.05074459509493740.9914137408262120.8975533299253590.06767925711961740.03935145168425670.9905949188754290.9170636174704840.0689986452822580.05994146669738050.9526700769487140.8470700329894710.06205944834995990.0585948456539570.9485825614838390.8456646890245510.05332554080850480.05574041597354540.9456094161715540.8477437335980870.08794734270684450.104697950796120.889353361133120.7243586586278070.08975681981187790.09177455247641980.9138203293620780.7633799325964391.017456249339091.309197003219881.027429410318891.070096004821911.021392936670561.021648636865971.034919895618841.056884666482531.059439613498381.138932899219991.116450961268281.668238008397991.095089475720361.070022051478231.071434757655691.064025597413961.054772960877151.091930622403431.093908234547310.702350764560360.4191085190247960.4202281772055070.4541839487254410.9380937295906040.9922159951112490.864307810261720.715764239491230.04833757400928990.8650604696200470.8102270333586320.4185728893330860.3676564405828830.3157047557160440.2815647446858870.342773365280935aSupplementary Table 4. Two sample Mendelian randomization estimations results with eight methods.6 y7P8599u:"A;;w<0==av>??I ]@ @ A! ,B BV jC ccc PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭V6{|Kۡ%C 7Aԅcۅ8T XadwuƝlmM=\('P^Ke#bc{lcw K 6CqKzV"B$L\!ԖovxuF]n# ]L-7Bc".$C΄M\KHt)Z,Kf~߅ .D6K2rA&5B%.lġ-F;`e!(^[>܇jRDsG,oafogBʼn3;J):F ,|BUƮĺ\U1sb!J>3Aq2{u-rRO#G` |q:e_#j=ջԵp[;3E %s@a7e.Wdrf||Fv<'Zz3$vO}|aQSO&!|Tm X#-q&?%2(b:^enh ғbQjU :R]wz6Ч3J<$ c65lQ9I$.źu~@- |z/@0SYtu0/3˜ieس #.ݞ]jgEH7D_٩VB㼱^CjS rcqX|mY)hZR?c%;B}B4/}"%B6S뢓VH=JƺhnU(,u(+9d<4n(OPZἫ/Vl cG+Wʁ"A17טe|s(]G4 ѴussB%] )ƋeX;f  ;  , , , , , , , , , , , , , , , ;  ,G NNNNNNNNNNNN D D D D D E E D D  F  F  D @ @ A~ AV@ J J( J8 J9 J:  J;  Jx  J @ @ ?~ ?V@ K K) K< K= K>  K?  Ky  K @ @ A~ AV@ J J* J@ JA JB  JC  Jz  J @ @ ?~ ?V@ K K+ KD KE KF  KG  K{  K @ @ A~ AV@ J J, JH JI JJ  JK  J|  J @ @ ?~ ?V@ K K- KL KM KN  KO  K}  K @ @ A~ AV@ J J. JP JQ JR  JS  J~  J H H I~ IV@ M& M/ MT MU Mu MV M M @ @ A~ A.@ J' J7 JW JX Jv Jw J J @ @ ?~ ?.@ K K0 KY KZ K[ K\ K K @ @ A~ A.@ J J1 J] J^ J_ J` J J @ @ ?~ ?.@ K! K2 Ka Kb Kc Kd K K @ @ A~ A.@ J" J3 Je Jf Jg  Jh  J  J @ @ ?~ ?.@ K# K4 Ki Kj Kk  Kl  K  K @ @ A~ A.@ J$ J5 Jm Jn Jo  Jp  J  J B B C~ C.@ L% L6 Lq Lr Ls  Lt  L  L OOOOOOOOOOOO * h.>@dOJ   7 ;BA' ?BA' ;BA' ?BA'   ;BA' ?BA'   ;BA' ?BA'{U{&;rf||{+{{U{&;rf||{+{{U{ &;rf||{+{ {U{ &;rf||{+{ ggD Oh+'0@HXl lenovo SaravananMicrosoft Excel@'m@gM՜.+,0 PXd lt|  Sheet1  Worksheets  !"#$%&'()*+,-./012456789:<=>?@ABRoot Entry F3_WorkbookdSummaryInformation(3DocumentSummaryInformation8;