%A Li, Yao 
%A Meng, Xue 
%A Luo, Yuqing 
%A Luo, Shuai 
%A Li, Jin 
%A Zeng, Jiafei 
%A Huang, Xiang 
%A Wang, Jinjing 
%D 2023
%T The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1
%! The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1
%K triple-negative breast cancer, miRNAs, miR-429, DLC1
%X Lines of evidence have demonstrated that the oncogenic miRNAs are pivotal to the progression of breast cancer. In this study, we investigated the biological traits of microRNA-429 (miR-429) in triple-negative breast cancer (TNBC) and the underlying molecular mechanism. We found that miR-429 was notably overexpressed in TNBC, and promoted TNBC cell proliferation, migration, and invasion by degrading the tumor suppressor DLC1. In conclusion, our findings reveal the mechanism of tumorigenic miR-429 in TNBC, which paves the way for target therapies translation in clinical settings.
%U https://doi.org/10.18632/aging.205051
%J Aging
%0 Journal Article
%V 15
%N 18
%P 9809-9821
%R 10.18632/aging.205051
%@ 1945-4589