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Warning Text %XTableStyleMedium2PivotStyleLight1683ffff̙̙3f3fff3f3f33333f33333\` K{UP ٝDOWN " d GO_P Term IDGO_P Term DescGO_P Term Level1GO_P Term Level2Term Candidate Gene NumTotal Candidate Gene Num Term Gene NumTotal Gene Num Rich RatioP valueQ value GO:0030198!extracellular matrix organizationbiological_process-cellular component organization or biogenesis GO:0007155 cell adhesionbiological adhesion GO:0030199collagen fibril organizationcellular process GO:0007156?homophilic cell adhesion via plasma membrane adhesion molecules GO:0001525 angiogenesisdevelopmental process GO:0008285)negative regulation of cell proliferationbiological regulation GO:0060337#type I interferon signaling pathway GO:0045071/negative regulation of viral genome replication GO:00323312negative regulation of chondrocyte differentiation GO:0043065(positive regulation of apoptotic process GO:0001957intramembranous ossification multicellular organismal process GO:0048706%embryonic skeletal system development GO:0007507heart development GO:0007162$negative regulation of cell adhesion GO:0007399nervous system development GO:0051607defense response to virusmulti-organism process GO:0048704'embryonic skeletal system morphogenesis GO:0038063=collagen-activated tyrosine kinase receptor signaling pathway GO:0031065,positive regulation of histone deacetylation GO:0042060 wound healingresponse to stimulus GO:0070374,positive regulation of ERK1 and ERK2 cascade GO:0016079synaptic vesicle exocytosis GO:00327360positive regulation of interleukin-13 production GO:0007411 axon guidance GO:0002376immune system process GO:0061061muscle structure development GO:0030574collagen catabolic processmetabolic process GO:0007160cell-matrix adhesion GO:0042476 odontogenesis GO:0016477cell migration localization GO:0006897 endocytosis GO:0098609cell-cell adhesion GO:0010718;positive regulation of epithelial to mesenchymal transition GO:0016525#negative regulation of angiogenesis GO:0048251elastic fiber assembly GO:0071526#semaphorin-plexin signaling pathway GO:0009615response to virus GO:00323322positive regulation of chondrocyte differentiation GO:0060325face morphogenesis GO:0008344adult locomotory behaviorbehavior GO:19032140regulation of protein targeting to mitochondrion GO:0061337cardiac conduction GO:0050808synapse organization GO:1904262&negative regulation of TORC1 signaling GO:0018057peptidyl-lysine oxidation GO:0043932(ossification involved in bone remodeling GO:00458439negative regulation of striated muscle tissue development regulation of biological process GO:0007049 cell cycle GO:0051301 cell division GO:0006281 DNA repair GO:0006260DNA replication GO:0007052mitotic spindle organization GO:0006974(cellular response to DNA damage stimulus GO:0006270DNA replication initiation GO:0006364rRNA processing GO:0007059chromosome segregation GO:0042254ribosome biogenesis GO:0036297interstrand cross-link repair GO:0000070$mitotic sister chromatid segregation GO:0000278mitotic cell cycle GO:0000398mRNA splicing, via spliceosome GO:0008380 RNA splicing GO:0006409tRNA export from nucleus GO:0000086%G2/M transition of mitotic cell cycle GO:0051028mRNA transport GO:0006397mRNA processing GO:0032508DNA duplex unwinding GO:00103893regulation of G2/M transition of mitotic cell cycle GO:0006406mRNA export from nucleus GO:0034080%CENP-A containing nucleosome assembly GO:0075733 intracellular transport of virus GO:1900034'regulation of cellular response to heat GO:00007247double-strand break repair via homologous recombination GO:00322016telomere maintenance via semi-conservative replication GO:0007084#mitotic nuclear envelope reassembly GO:19017967regulation of signal transduction by p53 class mediator GO:0006310DNA recombination GO:0000723telomere maintenance GO:00062711DNA strand elongation involved in DNA replication GO:0006110 regulation of glycolytic process GO:0016032 viral process GO:0036388 pre-replicative complex assembly GO:00311456anaphase-promoting complex-dependent catabolic process GO:0051321meiotic cell cycle GO:0007051spindle organization GO:0097711*ciliary basal body-plasma membrane docking GO:00007278double-strand break repair via break-induced replication GO:0007094#mitotic spindle assembly checkpoint GO:0051382kinetochore assembly GO:0060964%regulation of gene silencing by miRNA GO:0006913nucleocytoplasmic transport GO:0034501#protein localization to kinetochore GO:0007099centriole replication GO:0016925protein sumoylation GO:0006302double-strand break repair GO:0031297replication fork processing GO:0019058viral life cycle GO:0007080#mitotic metaphase plate congression GO:0006298mismatch repair GO:0006297+nucleotide-excision repair, DNA gap filling GO:0042273"ribosomal large subunit biogenesis GO:0051310metaphase plate congression GO:0006261DNA-dependent DNA replication GO:0042769,DNA damage response, detection of DNA damage GO:0006287!base-excision repair, gap-filling GO:0070317*negative regulation of G0 to G1 transition GO:0006396RNA processing GO:0007098centrosome cycle GO:0000083Mregulation of transcription involved in G1/S transition of mitotic cell cycle GO:0042276!error-prone translesion synthesis GO:0051298centrosome duplication GO:00062966nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006275regulation of DNA replication GO:0008334histone mRNA metabolic process GO:0007096regulation of exit from mitosis GO:0019985translesion synthesis GO:0033683(nucleotide-excision repair, DNA incision GO:19019901regulation of mitotic cell cycle phase transition GO:0000079Gregulation of cyclin-dependent protein serine/threonine kinase activity GO:0090305+nucleic acid phosphodiester bond hydrolysis GO:0006405RNA export from nucleus GO:0006268)DNA unwinding involved in DNA replication GO:0070987 error-free translesion synthesis GO:0000055+ribosomal large subunit export from nucleus GO:0044806G-quadruplex DNA unwinding GO:1902975"mitotic DNA replication initiation GO:0000082%G1/S transition of mitotic cell cycle GO:0000387spliceosomal snRNP assembly GO:0006264mitochondrial DNA replication GO:0051292nuclear pore complex assembly GO:1900264;positive regulation of DNA-directed DNA polymerase activity GO:1904851Hpositive regulation of establishment of protein localization to telomere GO:00063038double-strand break repair via nonhomologous end joining GO:0016070RNA metabolic process GO:0000462Xmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0090307mitotic spindle assembly GO:0006606protein import into nucleus GO:0000463Xmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:00062830transcription-coupled nucleotide-excision repair GO:0051276chromosome organization GO:0033314"mitotic DNA replication checkpoint GO:00513159attachment of mitotic spindle microtubules to kinetochore GO:19048719positive regulation of protein localization to Cajal body GO:0000056+ribosomal small subunit export from nucleus GO:0006267Opre-replicative complex assembly involved in nuclear cell cycle DNA replication GO:0006999nuclear pore organization GO:0007088&regulation of mitotic nuclear division GO:0044772#mitotic cell cycle phase transition GO:0008033tRNA processing GO:0000375/RNA splicing, via transesterification reactions GO:0051983$regulation of chromosome segregation GO:0030490maturation of SSU-rRNA GO:0045190isotype switching GO:1904874@positive regulation of telomerase RNA localization to Cajal body GO:0006284base-excision repair GO:0007131 reciprocal meiotic recombination GO:0032212<:positive regulation of telomere maintenance via telomerase GO:0000281mitotic cytokinesis GO:0006164&purine nucleotide biosynthetic process GO:0051170import into nucleus GO:0000467exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0006269(DNA replication, synthesis of RNA primer GO:0045132meiotic chromosome segregation GO:00063617transcription initiation from RNA polymerase I promoter GO:0006363-termination of RNA polymerase I transcription GO:0000245spliceosomal complex assembly GO:0000729"DNA double-strand break processing GO:0000731$DNA synthesis involved in DNA repair GO:2000042Nnegative regulation of double-strand break repair via homologous recombination GO:0051726regulation of cell cycle GO:0006457protein folding GO:00458152positive regulation of gene expression, epigenetic GO:0007095 mitotic G2 DNA damage checkpoint GO:0007064!mitotic sister chromatid cohesion GO:0007062sister chromatid cohesion GO:0000076DNA replication checkpoint GO:2000001#regulation of DNA damage checkpoint GO:2000234&positive regulation of rRNA processing GO:0007093mitotic cell cycle checkpoint GO:0016446-somatic hypermutation of immunoglobulin genes GO:0006272leading strand elongation GO:0006369.termination of RNA polymerase II transcription GO:0009116nucleoside metabolic process GO:0006189"'de novo' IMP biosynthetic process GO:0010032meiotic chromosome condensation GO:0010216maintenance of DNA methylation GO:0051383kinetochore organization GO:0019083viral transcription GO:0032465regulation of cytokinesis GO:0007018microtubule-based movement GO:0030488tRNA methylation GO:0007004#telomere maintenance via telomerase GO:0071897DNA biosynthetic process GO:0000480bendonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0045143!homologous chromosome segregation GO:0051256 mitotic spindle midzone assembly GO:0051988?regulation of attachment of spindle microtubules to kinetochore GO:1902570!protein localization to nucleolus GO:0006289nucleotide-excision repair GO:0042274"ribosomal small subunit biogenesis GO:00480255negative regulation of mRNA splicing, via spliceosome GO:1990830/cellular response to leukemia inhibitory factor GO:0008283cell proliferation GO:00164475somatic recombination of immunoglobulin gene segments GO:0042148strand invasion GO:0046602+regulation of mitotic centrosome separation GO:0046952ketone body catabolic process GO:0090666!scaRNA localization to Cajal body GO:0010332response to gamma radiation GO:0051225spindle assembly GO:0000077DNA damage checkpoint GO:0031573intra-S DNA damage checkpoint GO:00701926chromosome organization involved in meiotic cell cycle GO:0007005mitochondrion organization GO:0010569Eregulation of double-strand break repair via homologous recombination GO:0000460maturation of 5.8S rRNA GO:0001833"inner cell mass cell proliferation GO:0010457centriole-centriole cohesion GO:0031571 mitotic G1 DNA damage checkpoint GO:00459438positive regulation of transcription by RNA polymerase I GO:0071168!protein localization to chromatin GO:0010972<negative regulation of G2/M transition of mitotic cell cycle GO:0007076mitotic chromosome condensation GO:0000027 ribosomal large subunit assembly GO:00480265positive regulation of mRNA splicing, via spliceosome GO:0000479Xendonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0007057-spindle assembly involved in female meiosis I GO:0018171peptidyl-cysteine oxidation GO:0031291Ran protein signal transduction GO:0035984#cellular response to trichostatin A GO:00427906nucleolar large rRNA transcription by RNA polymerase I GO:0071932replication fork reversal GO:0044770cell cycle phase transition GO:00710358nuclear polyadenylation-dependent rRNA catabolic process GO:00710388nuclear polyadenylation-dependent tRNA catabolic process GO:0072719cellular response to cisplatin GO:19027517positive regulation of cell cycle G2/M phase transition GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0006390mitochondrial transcription GO:00300713regulation of mitotic metaphase/anaphase transition GO:0046599#regulation of centriole replication GO:0030261chromosome condensation GO:0000470maturation of LSU-rRNA GO:1905168Npositive regulation of double-strand break repair via homologous recombination GO:0031124mRNA 3'-end processing GO:0043928cexonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay)negative regulation of biological process GO:0010165response to X-ray GO:0007129synapsis GO:0045739!positive regulation of DNA repair GO:00086081attachment of spindle microtubules to kinetochore GO:0007019microtubule depolymerization GO:0043488regulation of mRNA stability GO:0010971<positive regulation of G2/M transition of mitotic cell cycle GO:0006977]DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0010824$regulation of centrosome duplication GO:0006166purine ribonucleoside salvage GO:0017196*N-terminal peptidyl-methionine acetylation GO:0034502"protein localization to chromosome GO:0043504mitochondrial DNA repair GO:0090267Epositive regulation of mitotic cell cycle spindle assembly checkpoint GO:0008630?intrinsic apoptotic signaling pathway in response to DNA damage GO:0051973*positive regulation of telomerase activity GO:0032259 methylation GO:00091688purine ribonucleoside monophosphate biosynthetic process GO:1903827+regulation of cellular protein localization GO:0006400tRNA modification GO:0006360!transcription by RNA polymerase I GO:0072711 cellular response to hydroxyurea GO:0016579protein deubiquitination GO:19020365regulation of hematopoietic stem cell differentiation GO:0043967histone H4 acetylation GO:0001933.negative regulation of protein phosphorylation GO:00065213regulation of cellular amino acid metabolic process GO:00070790mitotic chromosome movement towards spindle pole GO:0032487-regulation of Rap protein signal transduction GO:0036124histone H3-K9 trimethylation GO:0043137&DNA replication, removal of RNA primer GO:0045003Cdouble-strand break repair via synthesis-dependent strand annealing GO:00458760positive regulation of sister chromatid cohesion GO:0051754.meiotic sister chromatid cohesion, centromeric GO:00710428nuclear polyadenylation-dependent mRNA catabolic process GO:0014029neural crest formation GO:0031442-positive regulation of mRNA 3'-end processing GO:0034475U4 snRNA 3'-end processing GO:0000722&telomere maintenance via recombination GO:0016572histone phosphorylation GO:0090656t-circle formation GO:0006401RNA catabolic process GO:0006418+tRNA aminoacylation for protein translation GO:00007121resolution of meiotic recombination intermediates GO:0010212response to ionizing radiation GO:0006325chromatin organization GO:0000132,establishment of mitotic spindle orientationGSupplementary Table 4. 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