ࡱ>  ZO\pVelisage 09 Ba==\58X@"1Calibri1Calibri1Calibri1Calibri1Calibri1 Calibri1Calibri14Calibri1 Calibri1Calibri1Calibri1,6Calibri16Calibri16Calibri1>Calibri14Calibri1<Calibri1?Calibri1*h6 Calibri Light1Calibri1 Calibri"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_) #,##0\ "kr.";\-#,##0\ "kr."% #,##0\ "kr.";[Red]\-#,##0\ "kr."&!#,##0.00\ "kr.";\-#,##0.00\ "kr."+&#,##0.00\ "kr.";[Red]\-#,##0.00\ "kr."A<_-* #,##0\ "kr."_-;\-* #,##0\ "kr."_-;_-* "-"\ "kr."_-;_-@_-,'_-* #,##0_-;\-* #,##0_-;_-* "-"_-;_-@_-ID_-* #,##0.00\ "kr."_-;\-* #,##0.00\ "kr."_-;_-* "-"??\ "kr."_-;_-@_-4/_-* #,##0.00_-;\-* #,##0.00_-;_-* "-"??_-;_-@_-                                                                       ff         P@ @  P@ @  @       `@ @            a@ >   H1  H2  H<  H5   ||CЙ}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-} _-;_-* "}-} _-;_-* "}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef ?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L ?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A}  _-;_-* "23?\ "kr."}A}! _-;_-* "23 ?\ "kr."}A}" _-;_-* "?\ "kr."}A}# _-;_-* "?\ "kr."}A}$ _-;_-* "?\ "kr."}A}% _-;_-* "?\ "kr."}A}& _-;_-* "?\ "kr."}A}' _-;_-* " ?\ "kr."}A}( _-;_-* "?\ "kr."}}) }_-;_-* "?\ "kr."   }}* _-;_-* "?\ "kr."??? ??? ??? ???}-}+ _-;_-* "}-}, _-;_-* "}-}- _-;_-* "}-}. _-;_-* "}-}/ _-;_-* "}A}0 a_-;_-* "?\ "kr."}A}1 _-;_-* "?\ "kr."}A}2 _-;_-* "??\ "kr."}A}3 _-;_-* "23?\ "kr."}-}4 _-;_-* "}}5 ??v_-;_-* "̙?\ "kr."   }A}6 }_-;_-* "?\ "kr."}A}7 W_-;_-* "?\ "kr."}}8 _-;_-* "?\ "kr."   }}9 ???_-;_-* "?\ "kr."??? ??? ??? ???}-}: _-;_-* "}-}; _-;_-* "}U}< _-;_-* "?\ "kr." }-}= _-;_-* "}A}> _-;_-* "?\ "kr."}A}? _-;_-* "?\ "kr."}A}@ _-;_-* "?\ "kr."}A}A _-;_-* "?\ "kr."}-}B _-;_-* " 20% - Accent1M 20% - Accent1 ef % 20% - Accent2M" 20% - Accent2 ef % 20% - Accent3M& 20% - Accent3 ef % 20% - Accent4M* 20% - Accent4 ef % 20% - Accent5M. 20% - Accent5 ef % 20% - Accent6M2 20% - Accent6  ef % 40% - Accent1M 40% - Accent1 L % 40% - Accent2M# 40% - Accent2 L˭ % 40% - Accent3M' 40% - Accent3 L % 40% - Accent4M+ 40% - Accent4 L % 40% - Accent5M/ 40% - Accent5 L % 40% - Accent6M3 40% - Accent6  L % 60% - Accent1M 60% - Accent1 23 % 60% - Accent2M$ 60% - Accent2 23 % 60% - Accent3M( 60% - Accent3 23 % 60% - Accent4M, 60% - Accent4 23f % 60% - Accent5M0 60% - Accent5 23 %! 60% - Accent6M4 60% - Accent6  23Ў % "Accent1AAccent1 Dr % #Accent2A!Accent2 }1 % $Accent3A%Accent3  % %Accent4A)Accent4  % &Accent5A-Accent5 [ % 'Accent6A1Accent6  pG %(Bad9Bad  %) Calculation Calculation  }% * Check Cell Check Cell  %????????? ???+ Comma,( Comma [0]-&Currency.. Currency [0]/Explanatory TextG5Explanatory Text % 0Good;Good  a%1 Heading 1G Heading 1 DTj%Dr2 Heading 2G Heading 2 DTj%?3 Heading 3G Heading 3 DTj%234 Heading 49 Heading 4 DTj% 5InputuInput ̙ ??v% 6 Linked CellK Linked Cell }% 7NeutralANeutral  W%3Normal % 8Noteb Note   9OutputwOutput  ???%????????? ???:$Percent ;Title1Title DTj% <TotalMTotal %DrDr= Warning Text? Warning Text %XTableStyleMedium2PivotStyleLight16`#group_1_overlap_up_pathwaysN group 1 down5 Ataxia-telangiectasiaCockayne syndromeXPAidnum@Transcriptional activation of p53 responsive genes .R-HSA-69560Purine catabolism.R-HSA-74259*Sulfide oxidation to sulfate.R-HSA-16145170Biosynthesis of D-series resolvins.R-HSA-90186766Biosynthesis of E-series 18(R)-resolvins.R-HSA-90236616Biosynthesis of E-series 18(S)-resolvins.R-HSA-9018896.Biosynthesis of EPA-derived SPMs.R-HSA-9018679BBiosynthesis of aspirin-triggered D-series resolvins.R-HSA-90202651RHO GTPases Activate NADPH Oxidases.R-HSA-56685999RUNX3 regulates BCL2L11 (BIM) transcription.R-HSA-8952158ICarboxyterminal post-translational modifications of tubulin.R-HSA-8955332(Peroxisomal protein import.R-HSA-9033241Rho GTPase cycle.R-HSA-194840!Glycogen metabolism.R-HSA-8982491/Glycogen breakdown (glycogenolysis).R-HSA-70221'G1-S DNA Damage Checkpoints.R-HSA-69615-Nef Mediated CD8 Down-regulation.R-HSA-182218iDeregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.R-HSA-88628034Cytosolic iron-sulfur cluster assembly.R-HSA-25648306Degradation of cysteine and homocysteine.R-HSA-1614558#Nucleobase catabolism.R-HSA-8956319,Binding and entry of HIV virion.R-HSA-173107(Neurodegenerative Diseases.R-HSA-8863678*p75NTR regulates axonogenesis.R-HSA-193697:Ion influx-efflux at host-pathogen interface.R-HSA-6803544"Protein localization.R-HSA-96095075Formation of selenosugars for excretion.R-HSA-24084991Transcriptional regulation by RUNX2.R-HSA-8878166#Adenosine P1 receptors.R-HSA-4179734Beta-catenin independent WNT signaling.R-HSA-3858494'Metal ion SLC transporters.R-HSA-4254100p53-Dependent G1 DNA Damage Response.R-HSA-69563DSynthesis of Prostaglandins (PG) and Thromboxanes (TX).R-HSA-2162123Synthesis of PC.R-HSA-1483191'Assembly Of The HIV Virion.R-HSA-1754744p53-Dependent G1-S DNA damage checkpoint.R-HSA-695803Synthesis of 5-eicosatetraenoic acids.R-HSA-2142688?Synthesis of 15-eicosatetraenoic acid derivatives.R-HSA-2142770@Metabolism of ingested H2SeO4 and H2SeO3 into H2Se.R-HSA-2408550?Synthesis of 12-eicosatetraenoic acid derivatives.R-HSA-2142712ETranscriptional activation of cell cycle inhibitor p21 .R-HSA-69895EEndosomal Sorting Complex Required For Transport (ESCRT).R-HSA-917729.XBP1(S) activates chaperone genes.R-HSA-3810383WNT ligand biogenesis and trafficking.R-HSA-32386985WNT5A-dependent internalization of FZD4.R-HSA-5099900aVpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.R-HSA-180897MWNT ligand secretion is abrogated by the PORCN inhibitor LGK974.R-HSA-5340573DAP12 signaling.R-HSA-2424491 DAP12 interactions.R-HSA-2172127 Degradation of GABA.R-HSA-9168531Cytokine Signaling in Immune system.R-HSA-1280215+Downstream signal transduction.R-HSA-186763.VEGF ligand-receptor interactions.R-HSA-1943135Degradation of the extracellular matrix.R-HSA-1474228\Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.R-HSA-8864260uTransport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.R-HSA-1597637Extrinsic Pathway of Fibrin Clot Formation.R-HSA-140834/Extracellular matrix organization.R-HSA-1474244CErythropoietin activates Phospholipase C gamma (PLCG).R-HSA-9027277(Endosomal-Vacuolar pathway.R-HSA-1236977/Elevation of cytosolic Ca2+ levels.R-HSA-139853)Transport of small molecules.R-HSA-382551ERK-MAPK targets.R-HSA-198753"ER-Phagosome pathway.R-HSA-1236974%Triglyceride metabolism.R-HSA-8979227Complement cascade.R-HSA-166658*Type I hemidesmosome assembly.R-HSA-446107'Diseases of Immune System.R-HSA-5260271@Diseases associated with the TLR signaling cascade.R-HSA-5602358,Unfolded Protein Response (UPR).R-HSA-381119AVEGF binds to VEGFR leading to receptor dimerization.R-HSA-195399@Constitutive Signaling by NOTCH1 HD Domain Mutants.R-HSA-2691232,Cell-cell junction organization.R-HSA-421270 Collagen formation.R-HSA-1474290PRUNX2 regulates genes involved in differentiation of myeloid cells.R-HSA-8941333AAdvanced glycosylation endproduct receptor signaling.R-HSA-879415,Adherens junctions interactions.R-HSA-418990<Activation of gene expression by SREBF (SREBP).R-HSA-24261685Activation of Matrix Metalloproteinases.R-HSA-1592389$Activation of C3 and C5.R-HSA-1745773Activated NTRK3 signals through PLCG1.R-HSA-9034793>Activated NOTCH1 Transmits Signal to the Nucleus.R-HSA-2122948:ALKBH2 mediated reversal of alkylation damage.R-HSA-112122Nmitochondrial fatty acid beta-oxidation of unsaturated fatty acids.R-HSA-772883Antigen processing-Cross presentation.R-HSA-1236975:Vitamins B6 activation to pyridoxal phosphate.R-HSA-9649751Vif-mediated degradation of APOBEC3G.R-HSA-180585'Vasopressin-like receptors.R-HSA-388479IVasopressin regulates renal water homeostasis via Aquaporins.R-HSA-432040Urea cycle.R-HSA-70635Unwinding of DNA.R-HSA-176974(Uncoating of the HIV Virion.R-HSA-162585$Ubiquinol biosynthesis.R-HSA-2142789.Alternative complement activation.R-HSA-173736JAssembly of collagen fibrils and other multimeric structures.R-HSA-2022090*Collagen chain trimerization.R-HSA-8948216%Cell-Cell communication.R-HSA-15009319Collagen biosynthesis and modifying enzymes.R-HSA-1650814#Chylomicron clearance.R-HSA-89640261p75 NTR receptor-mediated signalling.R-HSA-193704%Cholesterol biosynthesis.R-HSA-191273%p75NTR signals via NF-kB.R-HSA-193639t(4&Cellular hexose transport.R-HSA-189200/Formation of annular gap junctions.R-HSA-196025:Cell recruitment (pro-inflammatory response).R-HSA-9664424&Axonal growth stimulation.R-HSA-209563'Cell junction organization.R-HSA-446728;Cell death signalling via NRAGE, NRIF and NADE.R-HSA-204998?Caspase-mediated cleavage of cytoskeletal proteins.R-HSA-264870QCaspase activation via Dependence Receptors in the absence of ligand.R-HSA-418889&CRMPs in Sema3A signaling.R-HSA-3999564Butyrophilin (BTN) family interactions.R-HSA-8851680GBiosynthesis of specialized proresolving mediators (SPMs).R-HSA-9018678.Biosynthesis of DHA-derived SPMs.R-HSA-90186778Formation of Fibrin Clot (Clotting Cascade).R-HSA-140877QGamma carboxylation, hypusine formation and arylsulfatase activation.R-HSA-163841FFormation of the beta-catenin:TCF transactivating complex.R-HSA-201722kNef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters.R-HSA-1649388Response to elevated platelet cytosolic Ca2+.R-HSA-76005$Response to metal ions.R-HSA-5660526?O-glycosylation of TSR domain-containing proteins.R-HSA-5173214(Nuclear signaling by ERBB4.R-HSA-1251985HNuclear Events (kinase and transcription factor activation).R-HSA-1987256Nitric oxide stimulates guanylate cyclase.R-HSA-392154&Neutrophil degranulation.R-HSA-6798695NSEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.R-HSA-3999558Negative regulation of the PI3K-AKT network.R-HSA-199418-Nef Mediated CD4 Down-regulation.R-HSA-167590RRemoval of aminoterminal propeptides from gamma-carboxylated proteins.R-HSA-159782,NTF3 activates NTRK3 signaling.R-HSA-9034013,NRAGE signals death through JNK.R-HSA-193648QNR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake .R-HSA-9031525`NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose.R-HSA-9031528JNR1H2 & NR1H3 regulate gene expression linked to lipogenesis.R-HSA-9029558INOTCH4 Activation and Transmission of Signal to the Nucleus.R-HSA-9013700INOTCH3 Activation and Transmission of Signal to the Nucleus.R-HSA-9013507INOTCH2 Activation and Transmission of Signal to the Nucleus.R-HSA-29790964STAT6-mediated induction of chemokines.R-HSA-3249367PCP-CE pathway.R-HSA-4086400=PI5P, PP2A and IER3 Regulate PI3K-AKT Signaling.R-HSA-68115585SUMOylation of immune response proteins.R-HSA-4755510=Purinergic signaling in leishmaniasis infection.R-HSA-96608264RUNX2 regulates chondrocyte maturation.R-HSA-8941284.RUNX2 regulates bone development.R-HSA-89413268RUNX2 regulates osteoblast differentiation.R-HSA-89409732RUNX3 regulates CDKN1< A transcription.R-HSA-8941855:RUNX3 regulates RUNX1-mediated transcription.R-HSA-89519112ROS and RNS production in phagocytes.R-HSA-1222556&RHO GTPases activate CIT.R-HSA-5625900:RHO GTPases Activate Rhotekin and Rhophilins.R-HSA-5666185,Regulated proteolysis of p75NTR.R-HSA-193692-Regulation of Complement cascade.R-HSA-977606+PINK1-PRKN Mediated Mitophagy.R-HSA-5205685!Protein methylation.R-HSA-88767258Post-translational protein phosphorylation.R-HSA-89572754Post-chaperonin tubulin folding pathway.R-HSA-389977$Platelet degranulation .R-HSA-114608)Platelet calcium homeostasis.R-HSA-418360*Plasma lipoprotein clearance.R-HSA-8964043CPlasma lipoprotein assembly, remodeling, and clearance.R-HSA-174824ARegulation of TP53 Activity through Phosphorylation.R-HSA-6804756-PKMTs methylate histone lysines.R-HSA-32148414NF-kB is activated and signals survival.R-HSA-209560Mitophagy.R-HSA-5205647YGLI proteins bind promoters of Hh responsive genes to promote transcription.R-HSA-5635851.The activation of arylsulfatases.R-HSA-1663150*IkBA variant leads to EDA-ID.R-HSA-5603029XTFAP2 (AP-2) family regulates transcription of other transcription factors.R-HSA-8866906+IRE1alpha activates chaperones.R-HSA-381070jTFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation.R-HSA-8869496MTP53 Regulates Transcription of Caspase Activators and Caspases.R-HSA-6803207>TP53 Regulates Transcription of Cell Death Genes.R-HSA-5633008TTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.R-HSA-6804116"The IPAF inflammasome.R-HSA-844623#The NLRP3 inflammasome.R-HSA-844456@Golgi Cisternae Pericentriolar Stack Reorganization.R-HSA-162658Inflammasomes.R-HSA-622312*Glycosphingolipid metabolism.R-HSA-1660662 Glycogen synthesis.R-HSA-3322077.Glycerophospholipid biosynthesis.R-HSA-1483206%Gap junction degradation.R-HSA-190873TGamma-carboxylation, transport, and amino-terminal cleavage of proteins.R-HSA-1598546Gamma-carboxylation of protein precursors.R-HSA-159740FTolerance by Mtb to nitric oxide produced by macrophages.R-HSA-1222538,GP1b-IX-V activation signalling.R-HSA-4301169Trafficking and processing of endosomal TLR.R-HSA-1679131UImmunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.R-HSA-198933.Influenza Virus Induced Apoptosis.R-HSA-1682774Mitochondrial transcription termination.R-HSA-163316'Signaling by NTRK3 (TRKC).R-HSA-90340152SUMOylation of transcription factors.R-HSA-3232118*Metallothioneins bind metals.R-HSA-5661231%Metabolism of vitamin K.R-HSA-6806664"Meiotic recombination.R-HSA-912446+Signaling by FGFR4 in disease.R-HSA-5655291=Signaling by NOTCH1 HD Domain Mutants in Cancer.R-HSA-2691230GLatent infection - Other responses of Mtb to phagocytosis.R-HSA-1222499!Signaling by NOTCH3.R-HSA-9012852LDL clearance.R-HSA-8964038Signaling by PDGF.R-HSA-186797OTFAP2 (AP-2) family regulates transcription of cell cycle factors.R-HSA-8866911<Signaling by high-kinase activity BRAF mutants.R-HSA-6802948"Ion channel transport.R-HSA-983712&Interleukin-10 signaling.R-HSA-6783783%Interleukin-1 processing.R-HSA-448706'Interferon gamma signaling.R-HSA-877300,Interferon alpha-beta signaling.R-HSA-909733!Interferon Signaling.R-HSA-913531EInterconversion of 2-oxoglutarate and 2-hydroxyglutarate.R-HSA-880009-Initial triggering of complement.R-HSA-166663Glucose metabolism.R-HSA-70326>RUNX2 regulates genes involved in cell migration.R-HSA-8941332$Lagging Strand Synthesis.R-HSA-69186,Prolonged ERK activation events.R-HSA-169893,G-protein beta:gamma signalling.R-HSA-397795!DNA strand elongation.R-HSA-69190RET signaling.R-HSA-8853659aRUNX1 regulates transcription of genes involved in differentiation of myeloid cells.R-HSA-8939246#Extension of Telomeres.R-HSA-180786+RUNX3 regulates WNT signaling.R-HSA-8951430$Recycling pathway of L1.R-HSA-437239$MAPK1 (ERK2) activation.R-HSA-1124115Cytosolic sulfonation of small molecules.R-HSA-1565849Regulation of RUNX2 expression and activity.R-HSA-89399029Regulation of RUNX3 expression and activity.R-HSA-8941858.Extra-nuclear estrogen signaling.R-HSA-9009391_Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.R-HSA-446388L1CAM interactions.R-HSA-373760-Inwardly rectifying K+ channels.R-HSA-1296065$Fanconi Anemia Pathway.R-HSA-6783310#Fatty acid metabolism.R-HSA-8978868?Removal of the Flap Intermediate from the C-strand.R-HSA-1744376Cholesterol biosynthesis via lathosterol.R-HSA-68070626Cholesterol biosynthesis via desmosterol.R-HSA-6807047,Removal of the Flap Intermediate.R-HSA-69166LInhibition of replication initiation of damaged DNA by RB1-E2F1.R-HSA-113501PInhibition of voltage gated Ca2+ channels via Gbeta-gamma subunits.R-HSA-997272(Prostanoid ligand receptors.R-HSA-3919086Processive synthesis on the lagging strand.R-HSA-69183Carnitine synthesis.R-HSA-71262AProcessive synthesis on the C-strand of the telomere.R-HSA-174414EMismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).R-HSA-5358565DMismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).R-HSA-5358606*Early Phase of HIV Life Cycle.R-HSA-1625940Eicosanoid ligand-binding receptors.R-HSA-391903Mismatch Repair.R-HSA-5358508+NFG and proNGF binds to p75NTR.R-HSA-205017,NTRK3 as a dependence receptor.R-HSA-96035052ER Quality Control Compartment (ERQC).R-HSA-901032Neddylation.R-HSA-8951664WNef mediated downregulation of MHC class I complex cell surface expression.R-HSA-164940:Negative feedback regulation of MAPK pathway.R-HSA-56744994EPH-ephrin mediated repulsion of cells.R-HSA-3928665"EPH-Ephrin signaling.R-HSA-2682334/Downregulation of ERBB4 signaling.R-HSA-1253288'Minus-strand DNA synthesis.R-HSA-164516$OAS antiviral response.R-HSA-8983711;Phosphate bond hydrolysis by NTPDase proteins.R-HSA-8850843:Platelet activation, signaling and aggregation.R-HSA-76002&Plus-strand DNA synthesis.R-HSA-164525%Metabolism of nucleotides.R-HSA-15869=Energy dependent regulation of mTOR by LKB1-AMPK.R-HSA-380972<Membrane binding and targetting of GAG proteins.R-HSA-1744907Prevention of phagosomal-lysosomal fusion.R-HSA-9636383 Histidine catabolism.R-HSA-709213Mitochondrial Fatty Acid Beta-Oxidation.R-HSA-77289Ca2+ pathway.R-HSA-40863985Asymmetric localization of PCP proteins.R-HSA-4608870GSynthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).R-HSA-2142816,GRB7 events in ERBB2 signaling.R-HSA-13069552Aryl hydrocarbon receptor signalling.R-HSA-8937144Synthesis of DNA.R-HSA-69239GSynthesis of active ubiquitin: roles of E1 and E2 enzymes.R-HSA-8866652%GABA receptor activation.R-HSA-977443'GABA B receptor activation.R-HSA-977444+G2-M DNA replication checkpoint.R-HSA-69478)Arachidonic acid metabolism.R-HSA-2142753)Aquaporin-mediated transport.R-HSA-445717CActivation of kainate receptors upon glutamate binding.R-HSA-451326bActivation of anterior HOX genes in hindbrain development during early embryogenesis.R-HSA-5617472)Activation of TRKA receptors.R-HSA-187015<Activation of HOX genes during differentiation.R-HSA-5619507*Activation of GABAB receptors.R-HSA-991365G2 Phase.R-HSA-68911>Activation of G protein gated Potassium channels.R-HSA-12960410TNFR1-mediated ceramide production.R-HSA-56269785TNFs bind their physiological receptors.R-HSA-5669034:Activation and oligomerization of BAK protein.R-HSA-1114529Telomere C-strand (Lagging Strand) Synthesis.R-HSA-1744176Termination of translesion DNA synthesis.R-HSA-56561690G protein gated Potassium channels.R-HSA-1296059<APOBEC3G mediated resistance to HIV-1 infection.R-HSA-1806897ADP signalling through P2Y purinoceptor 12.R-HSA-392170%Frs2-mediated activation.R-HSA-170968ASynthesis And Processing Of GAG, GAGPOL Polyproteins.R-HSA-174495EGap-filling DNA repair synthesis and ligation in GG-NER.R-HSA-5696397 HS-GAG degradation.R-HSA-2024096-Reverse Transcription of HIV RNA.R-HSA-162589?Sealing of the nuclear envelope (NE) by ESCRT-III.R-HSA-9668328&Signal transduction by L1.R-HSA-445144"Signaling by A< ctivin.R-HSA-1502540&Signaling by NTRK1 (TRKA).R-HSA-187037.G alpha (12-13) signalling events.R-HSA-416482(Signaling by WNT in cancer.R-HSA-4791275Hemostasis.R-HSA-109582@Binding of TCF-LEF:CTNNB1 to target gene promoters.R-HSA-4411364"Biological oxidations.R-HSA-211859GGlucagon-like Peptide-1 (GLP1) regulates insulin secretion.R-HSA-3816767Axonal growth inhibition (RHOA activation).R-HSA-1936343G beta:gamma signalling through CDC42.R-HSA-8964616YBH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.R-HSA-111453-Beta-oxidation of pristanoyl-CoA.R-HSA-389887#Syndecan interactions.R-HSA-30001705G beta:gamma signalling through PLC beta.R-HSA-4182171G beta:gamma signalling through BTK.R-HSA-89643150Mtb iron assimilation by chelation.R-HSA-1222449*Mitochondrial protein import.R-HSA-1268020Muscle contraction.R-HSA-397014:Mitochondrial iron-sulfur cluster biogenesis.R-HSA-1362409'Mitochondrial translation.R-HSA-53682875Formation of Incision Complex in GG-NER.R-HSA-56963953Mitochondrial translation termination.R-HSA-5419276GFormation of HIV-1 elongation complex containing HIV-1 Tat.R-HSA-1672008Formation of RNA Pol II elongation complex .R-HSA-1123822Mitochondrial translation initiation.R-HSA-5368286JFormation of HIV elongation complex in the absence of HIV Tat.R-HSA-167152Mitotic Prophase.R-HSA-688752Mitochondrial translation elongation.R-HSA-5389840*FCGR3A-mediated phagocytosis.R-HSA-96644227MyD88 cascade initiated on plasma membrane.R-HSA-975871HNef mediated downregulation of CD28 cell surface expression.R-HSA-164939_NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux.R-HSA-90295695Epigenetic regulation of gene expression.R-HSA-212165$ESR-mediated signaling.R-HSA-8939211!ERKs are inactivated.R-HSA-202670LERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.R-HSA-427389"NTRK2 activates RAC1.R-HSA-9032759.ER to Golgi Anterograde Transport.R-HSA-1999776EGFR interacts with phospholipase C-gamma.R-HSA-212718(Nef and signal transduction.R-HSA-164944?Negative epigenetic regulation of rRNA expression.R-HSA-5250941UNR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis.R-HSA-9623433 EGFR downregulation.R-HSA-1829711Negative regulation of MAPK pathway.R-HSA-5675221?E3 ubiquitin ligases ubiquitinate target proteins.R-HSA-8866654ZNegative regulation of activity of TFAP2 (AP-2) family transcription factors.R-HSA-88669049Negative regulators of DDX58-IFIH1 signaling.R-HSA-936440(Nephrin family interactions.R-HSA-373753'Neurexins and neuroligins.R-HSA-6794361Neuronal System.R-HSA-112316%Dual Incision in GG-NER.R-HSA-56964000NR1H2 and NR1H3-mediated signaling.R-HSA-9024446ONR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis .R-HSA-9632974:MyD88 dependent cascade initiated on endosome.R-HSA-975155=FOXO-mediated transcription of cell death genes.R-HSA-9614657,MyD88-independent TLR4 cascade .R-HSA-166166BMyD88:MAL(TIRAP) cascade initiated on plasma membrane.R-HSA-166058VNF-kB activation through FADD-RIP-1 pathway mediated by caspase-8 and -10.R-HSA-933543<Fcgamma receptor (FCGR) dependent phagocytosis.R-HSA-2029480*NGF-stimulated transcription.R-HSA-90316280NIK-->noncanonical NF-kB signaling.R-HSA-5676590Fatty acids.R-HSA-211935)FOXO-mediated transcription.R-HSA-9614085[FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes.R-HSA-9615017=FOXO-mediated transcription of cell cycle genes.R-HSA-96178280Estrogen-dependent gene expression.R-HSA-9018519FLT3 Signaling.R-HSA-9607240FCGR activation.R-HSA-2029481,NOSIP mediated eNOS trafficking.R-HSA-203754ANOTCH2 intracellular domain regulates transcription.R-HSA-2197563ANOTCH3 Intracellular Domain Regulates Transcription.R-HSA-9013508,FCERI mediated MAPK activation.R-HSA-2871796.FCERI mediated Ca+2 mobilization.R-HSA-28718099Estrogen-stimulated signaling through PRKCZ.R-HSA-9634635ANOTCH4 Intracellular Domain Regulates Transcription.R-HSA-90136951Mitochondrial calcium ion transport.R-HSA-8949215'ISG15 antiviral mechanism.R-HSA-1169408(MicroRNA (miRNA) biogenesis.R-HSA-203927:Intracellular signaling by second messengers.R-HSA-9006925'Interleukin-35 Signalling.R-HSA-89847225IKK complex recruitment mediated by RIP1.R-HSA-937041&Interleukin-38 signaling.R-HSA-9007892Hydrolysis of LPC.R-HSA-14831158Interleukin-4 and Interleukin-13 signaling.R-HSA-6785807!Hedgehog 'on' state.R-HSA-5632684,Interleukin-6 family signaling.R-HSA-6783589%Interleukin-6 signaling.R-HSA-1059683%Interleukin-9 signaling.R-HSA-8985947,Intracellular oxygen transport.R-HSA-8981607/HIV elongation arrest and recovery.R-HSA-167287&Interleukin-27 signaling.R-HSA-9020956,Intrinsic Pathway for Apoptosis.R-HSA-1096067Intrinsic Pathway of Fibrin Clot Formation.R-HSA-140837 Killing mechanisms.R-HSA-9664420$Leading Strand Synthesis.R-HSA-69109"Leishmania infection.R-HSA-9658195%Leishmania phagocytosis.R-HSA-9664417LLocalization of the PINCH-ILK-PARVIN complex to focal adhesions.R-HSA-446343)HIV Transcription Elongation.R-HSA-167169(HDACs deacetylate histones.R-HSA-3214815$Long-term potentiation.R-HSA-9620244>Interleukin-3, Interleukin-5 and GM-CSF signaling.R-HSA-512988&Interleukin-23 signaling.R-HSA-9020933M Phase.R-HSA-68886-Integration of energy metabolism.R-HSA-1636856IRAK2 mediated activation of TAK1 complex.R-HSA-9370427Infection with Mycobacterium tuberculosis.R-HSA-9635486SIRAK2 mediated activation of TAK1 complex upon TLR7-8 or 9 stimulation.R-HSA-975163'IRAK1 recruits IKK complex.R-HSA-937039;Inhibition of Signaling by Overexpressed EGFR.R-HSA-5638303JInlB-mediated entry of Listeria monocytogenes into host cell.R-HSA-8875360DIRAK1 recruits IKK complex upon TLR7-8 or 9 stimulation.R-HSA-975144!Innate Immune System.R-HSA-168249YInsertion of tail-anchored proteins into the endoplasmic reticulum membrane.R-HSA-9609523&Insulin receptor recycling.R-HSA-77387Integrin signaling.R-HSA-354192&Interleukin-21 signaling.R-HSA-9020958<Interactions of Tat with host cellular proteins.R-HSA-176034@Interconversion of nucleotide di- and triphosphates.R-HSA-499943+Interleukin-1 family signaling.R-HSA-446652=IL-6-type cytokine receptor ligand interactions.R-HSA-6788467%Interleukin-1 signaling.R-HSA-9020702,Interleukin-12 family signaling.R-HSA-447115&Interleukin-15 signaling.R-HSA-8983432%Interleukin-17 signaling.R-HSA-448424+Interleukin-2 family signaling.R-HSA-451927-Interleukin-20 family signaling.R-HSA-8854691(Lysosome Vesicle Biogenesis.R-HSA-432720%HATs acetylate histones.R-HSA-3214847LFormation of Senescence-Associated Heterochromatin Foci (SAHF).R-HSA-2559584*G alpha (z) signalling events.R-HSA-418597>GABA synthesis, release, reuptake and degradation.R-HSA-888590/MHC class II antigen presentation.R-HSA-2132295,MTF1 activates gene expression.R-HSA-5660489&G2-M DNA damage checkpoint.R-HSA-69473G2-M Checkpoints.R-HSA-69481MTOR signalling.R-HSA-165159G1-S Transition.R-HSA-69206!G-protein activation.R-HSA-202040Immune System.R-HSA-1682566G beta:gamma signalling through PI3Kgamma.R-HSA-392451QFormyl peptide receptors bind formyl peptides and many other ligands.R-HSA-444473-GPVI-mediated activation cascade.R-HSA-114604CFormation of tubulin folding intermediates by CCT-TriC.R-HSA-389960Macroautophagy.R-HSA-1632852<Formation of the HIV-1 Early Elongation Complex.R-HSA-167158&Formation of the Editosome.R-HSA-75094Meiosis.R-HSA-15006206Formation of the Early Elongation Complex.R-HSA-113418Meiotic synapsis.R-HSA-1221632!Metabolism of lipids.R-HSA-556833?Metabolism of water-soluble vitamins and cofactors.R-HSA-196849"Metalloprotease DUBs.R-HSA-5689901?MECP2 regulates transcription of neuronal ligands.R-HSA-9022702*GRB2 events in EGFR signaling.R-HSA-179812.Golgi-to-ER retrograde transport.R-HSA-88566887Glucagon signaling in metabolic regulation.R-HSA-163359:Glyoxylate metabolism and glycine degradation.R-HSA-389661"Glycoprotein hormones.R-HSA-209822"MAP kinase activat< ion.R-HSA-450294,Glycerophospholipid catabolism.R-HSA-6814848TGlutamate binding, activation of AMPA receptors and synaptic plasticity.R-HSA-399721'MAP2K and MAPK activation.R-HSA-56741358MAP3K8 (TPL2)-dependent MAPK1-3 activation.R-HSA-56842645Glutamate Neurotransmitter Release Cycle.R-HSA-210500Gluconeogenesis.R-HSA-70263+Glucagon-type ligand receptors.R-HSA-420092?Global Genome Nucleotide Excision Repair (GG-NER).R-HSA-5696399=MECP2 regulates neuronal receptors and channels.R-HSA-9022699,MAPK family signaling cascades.R-HSA-5683057*Generic Transcription Pathway.R-HSA-212436AMAPK targets- Nuclear events mediated by MAP kinases.R-HSA-450282+Gene expression (Transcription).R-HSA-74160`Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation.R-HSA-8950505#MAPK1-MAPK3 signaling.R-HSA-5684996%Gap junction trafficking.R-HSA-190828"Gap junction assembly.R-HSA-190861$MAPK3 (ERK1) activation.R-HSA-110056GGRB2:SOS provides linkage to MAPK signaling for Integrins .R-HSA-354194&Interleukin-12 signaling.R-HSA-9020591#2-LTR circle formation.R-HSA-164843LNeurotransmitter receptors and postsynaptic signal transmission.R-HSA-112314(Signaling by Retinoic Acid.R-HSA-5362517@Signaling by moderate kinase activity BRAF mutants.R-HSA-68029463Signaling by the B Cell Receptor (BCR).R-HSA-9837051Signaling downstream of RAS mutants.R-HSA-9649948Signalling to ERKs.R-HSA-187687 Signalling to STAT3.R-HSA-198745&Smooth Muscle Contraction.R-HSA-445355<Switching of origins to a post-replicative state.R-HSA-69052Synthesis of PG.R-HSA-14831482Synthesis of PIPs at the ER membrane.R-HSA-1483248Synthesis of PS.R-HSA-1483101RTAK1 activates NFkB by phosphorylation and activation of IKKs complex.R-HSA-445989TBC-RABGAPs.R-HSA-88542146TICAM1-dependent activation of IRF3-IRF7.R-HSA-9013973BTLR3-mediated TICAM1-dependent programmed cell death.R-HSA-90139572TNFR1-induced proapoptotic signaling.R-HSA-53577863TRAF3-dependent IRF activation pathway.R-HSA-918233DTRAF6 mediated IRF7 activation in TLR7-8 or 9 signaling.R-HSA-975110+TRAF6 mediated IRF7 activation.R-HSA-933541,TRAF6 mediated NF-kB activation.R-HSA-933542YTRAF6 mediated induction of NFkB and MAP kinases upon TLR7-8 or 9 activation.R-HSA-975138ITRAF6-mediated induction of TAK1 complex within TLR4 complex.R-HSA-9370722TRIF(TICAM1)-mediated TLR4 signaling .R-HSA-9370611TRIF-mediated programmed cell death.R-HSA-2562578%Signaling by Rho GTPases.R-HSA-194315&Signaling by RAS mutants.R-HSA-6802949+Neurotransmitter release cycle.R-HSA-112310XSignaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants.R-HSA-96737677SIRT1 negatively regulates rRNA expression.R-HSA-427359)SMAC (DIABLO) binds to IAPs .R-HSA-111463ISMAC(DIABLO)-mediated dissociation of IAP:caspase complexes .R-HSA-1114644SMAC, XIAP-regulated apoptotic response.R-HSA-1114692SUMO is conjugated to E1 (UBA2:SAE1).R-HSA-3065676CSema4D induced cell migration and growth-cone collapse.R-HSA-416572>Senescence-Associated Secretory Phenotype (SASP).R-HSA-25595825Serotonin Neurotransmitter Release Cycle.R-HSA-181429 Signal Transduction.R-HSA-162582!Signal amplification.R-HSA-392518/Signaling by BRAF and RAF fusions.R-HSA-6802952Signaling by EGFR.R-HSA-177929&Signaling by Interleukins.R-HSA-449147Signaling by NOTCH.R-HSA-157118+Signaling by NOTCH1 in Cancer.R-HSA-2644603!Signaling by NOTCH2.R-HSA-1980145!Signaling by NOTCH4.R-HSA-9013694'Signaling by NTRK2 (TRKB).R-HSA-9006115Signaling by NTRKs.R-HSA-166520,Signaling by Nuclear Receptors.R-HSA-9006931ASignaling by Overexpressed Wild-Type EGFR in Cancer.R-HSA-5638302+Signaling by PDGFR in disease.R-HSA-9671555>Signaling by PDGFRA extracellular domain mutants.R-HSA-9673770<Tat-mediated HIV elongation arrest and recovery.R-HSA-167243<Tat-mediated elongation of the HIV-1 transcript.R-HSA-1672463Telomere C-strand synthesis initiation.R-HSA-174430!Telomere Maintenance.R-HSA-1575795Transfer of LPS from LBP carrier to CD14.R-HSA-1660202Transferrin endocytosis and recycling.R-HSA-917977+Translesion synthesis by POLI.R-HSA-5656121+Translesion synthesis by POLK.R-HSA-5655862*Translesion synthesis by REV1.R-HSA-110312_Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.R-HSA-1103132Transmission across Chemical Synapses.R-HSA-112315?Transport to the Golgi and subsequent modification.R-HSA-948021$Triglyceride catabolism.R-HSA-163560!Tyrosine catabolism.R-HSA-8963684UCH proteinases.R-HSA-5689603.Ub-specific processing proteases.R-HSA-56898803VLDLR internalisation and degradation.R-HSA-8866427*Viral Messenger RNA Synthesis.R-HSA-1683251Vitamin B5 (pantothenate) metabolism.R-HSA-1992203WNT5:FZD7-mediated leishmania damping.R-HSA-9673324DWNT5A-dependent internalization of FZD2, FZD5 and ROR2.R-HSA-5140745mRNA Editing.R-HSA-75072+mRNA Editing: C to U Conversion.R-HSA-72200'mTORC1-mediated signalling.R-HSA-166208<p130Cas linkage to MAPK signaling for integrins.R-HSA-372708;p75NTR negatively regulates cell cycle via SC1.R-HSA-193670!phospho-PLA2 pathway.R-HSA-111995:Transcriptional regulation of granulopoiesis.R-HSA-96162226Transcriptional regulation by small RNAs.R-HSA-55787491Transcriptional regulation by RUNX1.R-HSA-88781710Toll Like Receptor 4 (TLR4) Cascade.R-HSA-166016"The AIM2 inflammasome.R-HSA-844615LThe citric acid (TCA) cycle and respiratory electron transport.R-HSA-1428517GThe role of GTSE1 in G2-M progression after G2 checkpoint.R-HSA-8852276JThe role of Nef in HIV-1 replication and disease pathogenesis.R-HSA-164952NThrombin signalling through proteinase activated receptors (PARs).R-HSA-4569267Thromboxane signalling through TP receptor.R-HSA-428930Tie2 Signaling.R-HSA-2109932Toll Like Receptor 10 (TLR10) Cascade.R-HSA-1681420Toll Like Receptor 2 (TLR2) Cascade.R-HSA-1814380Toll Like Receptor 3 (TLR3) Cascade.R-HSA-1681640Toll Like Receptor 5 (TLR5) Cascade.R-HSA-1681761Transcriptional Regulation by MECP2.R-HSA-89869444Toll Like Receptor 7-8 (TLR7-8) Cascade.R-HSA-1681810Toll Like Receptor 9 (TLR9) Cascade.R-HSA-1681381Toll Like Receptor TLR1:TLR2 Cascade.R-HSA-1681791Toll Like Receptor TLR6:TLR2 Cascade.R-HSA-168188(Toll-like Receptor Cascades.R-HSA-1688989Toxicity of botulinum toxin type C (BoNT-C).R-HSA-5250971.Toxicity of tetanus toxin (TeNT).R-HSA-5250982*Trafficking of AMPA receptors.R-HSA-399719;Trafficking of GluR2-containing AMPA receptors.R-HSA-416993ATrafficking of myristoylated proteins to the cilium.R-HSA-5624138*SHC1 events in EGFR signaling.R-HSA-180336S Phase.R-HSA-692423Role of phospholipids in phagocytosis.R-HSA-2029485;Pyruvate metabolism and Citric Acid (TCA) cycle.R-HSA-714060Phase II - Conjugation of compounds.R-HSA-1565803Phenylalanine and tyrosine metabolism.R-HSA-8963691%Phospholipid metabolism.R-HSA-14832571Platelet Adhesion to exposed collagen.R-HSA-758921Platelet Aggregation (Plug Formation).R-HSA-76009!Platelet homeostasis.R-HSA-418346-Polo-like kinase mediated events.R-HSA-156711APolymerase switching on the C-strand of the telomere.R-HSA-174411 Polymerase switching.R-HSA-69091?Positive epigenetic regulation of rRNA expression.R-HSA-52509131Post NMDA receptor activation events.R-HSA-4380644Post-translational protein modification.R-HSA-597592 Potassium Channels.R-HSA-12960711Pre-NOTCH Expression and Processing.R-HSA-19124225Pre-NOTCH Transcription and Translation.R-HSA-1912408BPrefoldin mediated transfer of substrate to CCT-TriC.R-HSA-3899576Presynaptic function of Kainate receptors.R-HSA-5006578Processing of DNA double-strand break ends.R-HSA-5693607!Processing of SMDT1.R-HSA-8949664#Programmed Cell Death.R-HSA-5357801BProstacyclin signalling through prostacyclin receptor.R-HSA-392851Protein folding.R-HSA-391251$Protein ubiquitination.R-HSA-8852135)Peptide hormone biosynthesis.R-HSA-209952@Pausing and recovery of Tat-mediated HIV elongation.R-HSA-1672383Pausing and recovery of HIV elongation.R-HSA-167290,Ovarian tumor domain proteases.R-HSA-5689896< 6NoRC negatively regulates rRNA expression.R-HSA-427413.Nonhomologous End-Joining (NHEJ).R-HSA-5693571:Norepinephrine Neurotransmitter Release Cycle.R-HSA-181430 Nucleosome assembly.R-HSA-774815(Nucleotide Excision Repair.R-HSA-5696398)Oncogene Induced Senescence.R-HSA-2559585&Oncogenic MAPK signaling.R-HSA-6802957Opioid Signalling.R-HSA-111885'Orc1 removal from chromatin.R-HSA-68949'Organic anion transporters.R-HSA-4286431Oxidative Stress Induced Senescence.R-HSA-2559580 Parasite infection.R-HSA-9664407 PECAM1 interactions.R-HSA-210990@PI and PC transport between ER and Golgi membranes.R-HSA-1483196*PI3K-AKT Signaling in Cancer.R-HSA-2219528-PI5P Regulates TP53 Acetylation.R-HSA-6811555*PIP3 activates AKT signaling.R-HSA-1257604"PLC-gamma1 signalling.R-HSA-167021-PRC2 methylates histones and DNA.R-HSA-212300PTEN Regulation.R-HSA-6807070'Packaging Of Telomere Ends.R-HSA-171306MParadoxical activation of RAF signaling by kinase inactive BRAF.R-HSA-68029556Protein-protein interactions at synapses.R-HSA-6794362Pyruvate metabolism.R-HSA-70268/Retrograde neurotrophin signalling.R-HSA-1775043RAB GEFs exchange GTP for GDP on RABs.R-HSA-8876198!Recycling of eIF2:GDP.R-HSA-72731'Reelin signalling pathway.R-HSA-8866376 Regulated Necrosis.R-HSA-5218859)Regulation of IFNG signaling.R-HSA-8773129Regulation of MECP2 expression and activity.R-HSA-90226921Regulation of PTEN mRNA translation.R-HSA-89437234Regulation of TLR by endogenous ligand.R-HSA-5686938=Regulation of TP53 Activity through Acetylation.R-HSA-6804758GRegulation of actin dynamics for phagocytic cup formation.R-HSA-20294820Regulation of beta-cell development.R-HSA-186712ERegulation of cholesterol biosynthesis by SREBP (SREBF).R-HSA-16558297Regulation of cortical dendrite branching.R-HSA-8985801]Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.R-HSA-210746qRegulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.R-HSA-210744,Regulation of insulin secretion.R-HSA-422356FRegulation of localization of FOXO transcription factors.R-HSA-9614399?Regulation of pyruvate dehydrogenase (PDH) complex.R-HSA-204174?Release of apoptotic factors from the mitochondria.R-HSA-111457Reproduction.R-HSA-1474165QResolution of AP sites via the single-nucleotide replacement pathway.R-HSA-1103811Resolution of Abasic Sites (AP sites).R-HSA-73933Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-163200+Respiratory electron transport.R-HSA-611105wRecruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.R-HSA-5693565gRecognition and association of DNA glycosylase with site containing an affected pyrimidine.R-HSA-110328cRecognition and association of DNA glycosylase with site containing an affected purine.R-HSA-110330.RMTs methylate histone arginines.R-HSA-3214858$RAF-MAP kinase cascade.R-HSA-5673001/RAF-independent MAPK1-3 activation.R-HSA-112409!RHO GTPase Effectors.R-HSA-195258(RHO GTPases Activate ROCKs.R-HSA-56271172RHO GTPases Activate WASPs and WAVEs.R-HSA-5663213)RHO GTPases activate IQGAPs.R-HSA-5626467'RHO GTPases activate PAKs.R-HSA-5627123'RHO GTPases activate PKNs.R-HSA-56257403RIP-mediated NFkB activation via ZBP1.R-HSA-1810476/RIPK1-mediated regulated necrosis.R-HSA-5213460/RNA Polymerase I Promoter Clearance.R-HSA-73854)Receptor Mediated Mitophagy.R-HSA-8934903,RNA Polymerase I Promoter Escape.R-HSA-73772-RNA Polymerase I Promoter Opening.R-HSA-737286RNA Polymerase I Transcription Termination.R-HSA-738635Displacement of DNA glycosylase by APEX1.R-HSA-110357*RNA Polymerase I Transcription.R-HSA-73864cRUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.R-HSA-8936459XRUNX1 regulates transcription of genes involved in differentiation of HSCs.R-HSA-8939236@RUNX3 Regulates Immune Response and Cell Migration.R-HSA-8949275-RUNX3 regulates NOTCH signaling.R-HSA-8941856+Rab regulation of trafficking.R-HSA-90071014Dopamine Neurotransmitter Release Cycle.R-HSA-2126767TCF dependent signaling in response to WNT.R-HSA-201681-Disinhibition of SNARE formation.R-HSA-1145165Disorders of transmembrane transporters.R-HSA-5619115Creatine metabolism.R-HSA-71288DNA Damage Reversal.R-HSA-73942FDeactivation of the beta-catenin transactivating complex.R-HSA-3769402Dectin-2 family.R-HSA-56214803Defective CFTR causes cystic fibrosis.R-HSA-56788953Degradation of GLI1 by the proteasome.R-HSA-56107803Degradation of GLI2 by the proteasome.R-HSA-56107834Depolymerisation of the Nuclear Lamina.R-HSA-4419969Digestion.R-HSA-8935690&Dissolution of Fibrin Clot.R-HSA-752054Common Pathway of Fibrin Clot Formation.R-HSA-1408759Drug-mediated inhibition of ERBB2 signaling.R-HSA-9652282ECM proteoglycans.R-HSA-3000178,ERBB2 Activates PTK6 Signaling.R-HSA-8847993%Elastic fibre formation.R-HSA-1566948TEstrogen-dependent nuclear events downstream of ESR-membrane signaling.R-HSA-9634638.FGFR3 mutant receptor activation.R-HSA-2033514.FGFR4 mutant receptor activation.R-HSA-1839128'Fatty acyl-CoA biosynthesis.R-HSA-75105*Fibronectin matrix formation.R-HSA-1566977$Constitutive Signaling by NOTCH1 t(7$Chylomicron remodeling.R-HSA-8963901.Netrin mediated repulsion signals.R-HSA-418886<Autodegradation of the E3 ubiquitin ligase COP1.R-HSA-3494252Activated NTRK3 signals through PI3K.R-HSA-9603381AActivation of BIM and translocation to mitochondria .R-HSA-1114469Activation of NIMA Kinases NEK9, NEK6, NEK7.R-HSA-2980767Adrenoceptors.R-HSA-3906962Antagonism of Activin by Follistatin.R-HSA-2473224$Antimicrobial peptides.R-HSA-68031574Apoptotic cleavage of cellular proteins.R-HSA-111465-Attachment of GPI anchor to uPAR.R-HSA-162791Attenuation phase.R-HSA-3371568Axon guidance.R-HSA-422475"Chylomicron assembly.R-HSA-8963888!Basigin interactions.R-HSA-210991:Beta-oxidation of very long chain fatty acids.R-HSA-390247BBinding and Uptake of Ligands by Scavenger Receptors.R-HSA-2173782;CD163 mediating an anti-inflammatory response.R-HSA-9662834=CDT1 association with the CDC6:ORC:origin complex.R-HSA-68827!CREB phosphorylation.R-HSA-199920.Cellular response to heat stress.R-HSA-3371556*Chaperone Mediated Autophagy.R-HSA-96138290Chemokine receptors bind chemokines.R-HSA-380108*G alpha (i) signalling events.R-HSA-418594:GLI3 is processed to GLI3R by the proteasome.R-HSA-5610785*Glycosaminoglycan metabolism.R-HSA-16303160Metabolism of fat-soluble vitamins.R-HSA-6806667"Leukotriene receptors.R-HSA-391906*Ligand-receptor interactions.R-HSA-5632681)Lipid particle organization.R-HSA-8964572/Lysosphingolipid and LPA receptors.R-HSA-4194083MECP2 regulates transcription factors.R-HSA-9022707OMECP2 regulates transcription of genes involved in GABA signaling.R-HSA-9022927;Metabolism of Angiotensinogen to Angiotensins.R-HSA-2022377'Metabolism of carbohydrates.R-HSA-71387%Metabolism of cofactors.R-HSA-89789341Metabolism of vitamins and cofactors.R-HSA-196854HDL assembly.R-HSA-8963896;Metal sequestration by antimicrobial proteins.R-HSA-6799990]Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.R-HSA-1908406Molecules associated with elastic fibres.R-HSA-2129379Myogenesis.R-HSA-525793HN-glycan trimming in the ER and Calnexin-Calreticulin cycle.R-HSA-532668,NGF-independant TRKA activation.R-HSA-1870245NRIF signals cell death from the nucleus.R-HSA-2050433NTF3 activates NTRK2 (TRKB) signaling.R-HSA-90250463NTF4 activates NTRK2 (TRKB) signaling.R-HSA-9026357+Late endosomal microautophagy.R-HSA-9615710"Laminin interactions.R-HSA-30001570Keratan sulfate-keratin metabolism.R-HSA-1638074)Keratan sulfate degradation.R-HSA-2022857HDL clearance.R-HSA-8964011HDL remodeling.R-HSA-8964058!HS-GAG biosynthesis.R-HSA-2022928HSF1 activation.R-HSA-3371511,HSF1-dependent transactivation.R-HSA-3371571(Hedgehog ligand biogenesis.R-HSA-53583469Heparan sulfate-hep< arin (HS-GAG) metabolism.R-HSA-16380912Hh mutants abrogate ligand secretion.R-HSA-5387390YHh mutants that don't undergo autocatalytic processing are degraded by ERAD.R-HSA-5362768#Hyaluronan metabolism.R-HSA-2142845/Hyaluronan uptake and degradation.R-HSA-21609163IRF3-mediated induction of type I IFN.R-HSA-3270619AInhibition of Host mRNA Processing and RNA Silencing.R-HSA-1683157Inhibition of TSC complex formation by PKB.R-HSA-165181/Integrin cell surface interactions.R-HSA-216083&Interleukin-18 signaling.R-HSA-9012546$Interleukin-36 pathway.R-HSA-9014826&Iron uptake and transport.R-HSA-917937*Keratan sulfate biosynthesis.R-HSA-2022854AAcrosome Reaction and Sperm:Oocyte Membrane Binding.R-HSA-13006458AUF1 (hnRNP D0) binds and destabilizes mRNA.R-HSA-4504083ATF6 (ATF6-alpha) activates chaperones.R-HSA-381033;Integration of viral DNA into host genomic DNA.R-HSA-175567RFBXL7 down-regulates AURKA during mitotic entry and in early mitosis.R-HSA-88540506Formation of ATP by chemiosmotic coupling.R-HSA-163210*G alpha (q) signalling events.R-HSA-416476'G1-S-Specific Transcription.R-HSA-69205GHighly calcium permeable nicotinic acetylcholine receptors.R-HSA-629597THighly calcium permeable postsynaptic nicotinic acetylcholine receptors.R-HSA-629594SHighly sodium permeable postsynaptic acetylcholine nicotinic receptors.R-HSA-629587KInlA-mediated entry of Listeria monocytogenes into host cells.R-HSA-8876493$Integration of provirus.R-HSA-162592/Interleukin receptor SHC signaling.R-HSA-912526<Na+-Cl- dependent neurotransmitter transporters.R-HSA-4426603MASTL Facilitates Mitotic Progression.R-HSA-2465910!MET activates STAT3.R-HSA-8875791$MET receptor recycling.R-HSA-8875656.Metabolism of folate and pterines.R-HSA-196757%Miscellaneous substrates.R-HSA-2119581Mitotic G1 phase and G1-S transition.R-HSA-4532791Mitotic Metaphase-Anaphase Transition.R-HSA-688815Modulation by Mtb of host immune system.R-HSA-9637628-Molybdenum cofactor biosynthesis.R-HSA-947581Ephrin signaling.R-HSA-3928664+ERBB2 Regulates Cell Motility.R-HSA-67856315Downregulation of ERBB2:ERBB3 signaling.R-HSA-1358803/Downregulation of ERBB2 signaling.R-HSA-88637958Acetylcholine binding and downstream events.R-HSA-1814319Autointegration results in viral DNA circles.R-HSA-1775391Beta-catenin phosphorylation cascade.R-HSA-196299DBiosynthesis of A2E, implicated in retinal degradation.R-HSA-2466712Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.R-HSA-446193,Biotin transport and metabolism.R-HSA-196780<CDK-mediated phosphorylation and removal of Cdc6.R-HSA-69017'CTLA4 inhibitory signaling.R-HSA-389513JChk1-Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.R-HSA-750351Class A-1 (Rhodopsin-like receptors).R-HSA-3730762Class B-2 (Secretin family receptors).R-HSA-373080-Costimulation by the CD28 family.R-HSA-388841CCyclin A-B1-B2 associated events during G2-M transition.R-HSA-69273\DEx-H-box helicases activate type I IFN and inflammatory cytokines production .R-HSA-3134963!Degradation of AXIN.R-HSA-4641257CDegradation of beta-catenin by the destruction complex.R-HSA-195253\Disassembly of the destruction complex and recruitment of AXIN to the membrane.R-HSA-4641262:Diseases associated with visual transduction.R-HSA-2474795-Diseases of the neuronal system.R-HSA-9675143,NADE modulates death signalling.R-HSA-205025VNegative regulation of TCF-dependent signaling by WNT ligand antagonists.R-HSA-37724708ATF6 (ATF6-alpha) activates chaperone genes.R-HSA-3811833alpha-linolenic acid (ALA) metabolism.R-HSA-2046106!Tryptophan catabolism.R-HSA-71240CUbiquitin Mediated Degradation of Phosphorylated Cdc25A.R-HSA-69601,Vitamin B1 (thiamin) metabolism.R-HSA-196819.Vitamin D (calciferol) metabolism.R-HSA-196791,Vpu mediated degradation of CD4.R-HSA-180534.Wax and plasmalogen biosynthesis.R-HSA-8848584Wax biosynthesis.R-HSA-96404639XAV939 inhibits tankyrase, stabilizing AXIN.R-HSA-55456198activated TAK1 mediates p38 MAPK activation.R-HSA-4503020betaKlotho-mediated ligand binding.R-HSA-1307965%Nucleobase biosynthesis.R-HSA-89563203mRNA decay by 5' to 3' exoribonuclease.R-HSA-430039/p53-Independent DNA Damage Response.R-HSA-696106p53-Independent G1-S DNA damage checkpoint.R-HSA-69613,tRNA processing in the nucleus.R-HSA-6784531tRNA processing.R-HSA-72306vRNP Assembly.R-HSA-192905MA tetrasaccharide linker sequence is required for GAG synthesis.R-HSA-1971475'ABC transporter disorders.R-HSA-5619084;ARL13B-mediated ciliary trafficking of INPP5E.R-HSA-5624958(Transport of organic anions.R-HSA-8795189Toxicity of botulinum toxin type A (BoNT-A).R-HSA-5250968#The NLRP1 inflammasome.R-HSA-8444552Tachykinin receptors bind tachykinins.R-HSA-3800955Phase I - Functionalization of compounds.R-HSA-211945$Phosphorylation of Emi1.R-HSA-176417@Postmitotic nuclear pore complex (NPC) reformation.R-HSA-9615933;Postsynaptic nicotinic acetylcholine receptors.R-HSA-622327:Presynaptic nicotinic acetylcholine receptors.R-HSA-622323Protein repair.R-HSA-5676934<Purine ribonucleoside monophosphate biosynthesis.R-HSA-73817/Reduction of cytosolic Ca++ levels.R-HSA-418359-Regulation of PTEN localization.R-HSA-89487477Regulation of PTEN stability and activity.R-HSA-8948751PRegulation of activated PAK-2p34 by proteasome mediated degradation.R-HSA-211733NRegulation of gene expression in early pancreatic precursor cells.R-HSA-2107476Release of Hh-Np from the secreting cell.R-HSA-5362798+Retinoid cycle disease events.R-HSA-2453864Signaling by WNT.R-HSA-195721.Signalling to p38 via RIT and RIN.R-HSA-187706&Sodium-Calcium exchangers.R-HSA-425561MSynthesis of bile acids and bile salts via 24-hydroxycholesterol.R-HSA-1937756TNFR1-induced NFkappaB signaling pathway.R-HSA-5357956(Nervous system development.R-HSA-96751089Neurophilin interactions with VEGF and VEGFR.R-HSA-194306^Diseases of signal transduction by growth factor receptors and second messengers.R-HSA-5663202*CD22 mediated BCR regulation.R-HSA-5690714 Base Excision Repair.R-HSA-738843Base-Excision Repair, AP Site Formation.R-HSA-73929<Biosynthesis of DHA-derived sulfido conjugates.R-HSA-9026395fBiosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR).R-HSA-90267661Blockage of phagosome acidification.R-HSA-9636467,Breakdown of the nuclear lamina.R-HSA-3522381Budding and maturation of HIV virion.R-HSA-162588,C-type lectin receptors (CLRs).R-HSA-5621481'CD209 (DC-SIGN) signaling.R-HSA-5621575 CD28 co-stimulation.R-HSA-389356Autophagy.R-HSA-9612973.CD28 dependent PI3K-Akt signaling.R-HSA-389357)CLEC7A (Dectin-1) signaling.R-HSA-5607764)CLEC7A-inflammasome pathway.R-HSA-5660668;COPI-dependent Golgi-to-ER retrograde traffic.R-HSA-6811434=COPI-independent Golgi-to-ER retrograde traffic.R-HSA-68114361COPI-mediated anterograde transport.R-HSA-6807878-COPII-mediated vesicle transport.R-HSA-204005YCREB1 phosphorylation through the activation of CaMKII-CaMKK-CaMKIV cascasde.R-HSA-442729*CREB3 factors activate genes.R-HSA-8874211AB-WICH complex positively regulates rRNA expression.R-HSA-5250924MAssociation of TriC-CCT with target proteins during biosynthesis.R-HSA-3904714Non-integrin membrane-ECM interactions.R-HSA-3000171)Amino acids regulate mTORC1.R-HSA-9639288LActivation of the TFAP2 (AP-2) family of transcription factors.R-HSA-88669075Activation of the pre-replicative complex.R-HSA-68962)Acyl chain remodeling of CL.R-HSA-1482798*Acyl chain remodelling of PC.R-HSA-1482788*Acyl chain remodelling of PE.R-HSA-1482839$Adaptive Immune System.R-HSA-12802181Adenylate cyclase inhibitory pathway.R-HSA-170670@Adrenaline,noradrenaline inhibits insulin secretion.R-HSA-400042Aggrephagy.R-HSA-9646399$Amyloid fiber formation.R-HSA-9772253Assembly of the pre-replicative complex.R-HSA-68867WAntigen Presentation: Folding, assembly and peptide loading of class I MHC.R-HSA-983170_Antigen activates B Cell Receptor (BCR) leading to generation of second messen< gers.R-HSA-983695HAntigen processing: Ubiquitination & Proteasome degradation.R-HSA-9831689Antiviral mechanism by IFN-stimulated genes.R-HSA-11694100Apoptosis induced DNA fragmentation.R-HSA-140342Apoptosis.R-HSA-109581%Apoptotic execution phase.R-HSA-75153.Asparagine N-linked glycosylation.R-HSA-446203FAssembly and cell surface presentation of NMDA receptors.R-HSA-96097365CaMK IV-mediated phosphorylation of CREB.R-HSA-111932ACargo recognition for clathrin-mediated endocytosis.R-HSA-8856825!Carnitine metabolism.R-HSA-200425*DNA Replication Pre-Initiation.R-HSA-69002?Constitutive Signaling by Aberrant PI3K in Cancer.R-HSA-2219530Cristae formation.R-HSA-8949613DDDX58-IFIH1-mediated induction of interferon-alpha-beta.R-HSA-168928DNA Damage Bypass.R-HSA-73893.DNA Damage Recognition in GG-NER.R-HSA-5696394;DNA Damage-Telomere Stress Induced Senescence.R-HSA-2559586.DNA Double Strand Break Response.R-HSA-5693606,DNA Double-Strand Break Repair.R-HSA-5693532DNA Repair.R-HSA-73894DNA Replication.R-HSA-69306MCaspase activation via Death Receptors in the presence of ligand.R-HSA-140534DNA methylation.R-HSA-5334118&DNA replication initiation.R-HSA-68952DSCAM interactions.R-HSA-376172<Dectin-1 mediated noncanonical NF-kB signaling.R-HSA-5607761MDeposition of new CENPA-containing nucleosomes at the centromere.R-HSA-606279Depurination.R-HSA-73927Depyrimidination.R-HSA-73928Deubiquitination.R-HSA-5688426#Developmental Biology.R-HSA-1266738;Constitutive Signaling by AKT1 E17K in Cancer.R-HSA-56744002Condensation of Prophase Chromosomes.R-HSA-2299718"Complex I biogenesis.R-HSA-6799198JCompeting endogenous RNAs (ceRNAs) regulate PTEN translation.R-HSA-8948700KCaspase activation via extrinsic apoptotic signalling pathway.R-HSA-5357769"Cell Cycle Checkpoints.R-HSA-69620Cell Cycle.R-HSA-1640170;Cell surface interactions at the vascular wall.R-HSA-2027333Cell-extracellular matrix interactions.R-HSA-446353!Cellular Senescence.R-HSA-2559583)Chromatin modifying enzymes.R-HSA-3247509$Chromatin organization.R-HSA-4839726"Chromosome Maintenance.R-HSA-73886)Citric acid cycle (TCA cycle).R-HSA-71403CClass I MHC mediated antigen processing & presentation.R-HSA-9831699Class I peroxisomal membrane protein import.R-HSA-9603798>Classical antibody-mediated complement activation.R-HSA-173623+Clathrin-mediated endocytosis.R-HSA-8856828+Cleavage of the damaged purine.R-HSA-1103310Cleavage of the damaged pyrimidine .R-HSA-110329BCobalamin (Cbl, vitamin B12) transport and metabolism.R-HSA-196741$Coenzyme A biosynthesis.R-HSA-196783"Collagen degradation.R-HSA-1442490CActivation of the AP-1 family of transcription factors.R-HSA-450341HActivation of caspases through apoptosome-mediated cleavage.R-HSA-1114595Activation of RAC1 downstream of NMDARs.R-HSA-9619229=Reversal of alkylation damage by DNA dioxygenases.R-HSA-73943=Regulation of HSF1-mediated heat shock response.R-HSA-3371453)Regulation of IFNA signaling.R-HSA-912694Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).R-HSA-381426MRegulation of TP53 Activity through Association with Co-factors.R-HSA-6804759+Regulation of TP53 Expression.R-HSA-6804754DRegulation of innate immune responses to cytosolic DNA.R-HSA-3134975Relaxin receptors.R-HSA-444821,Repression of WNT target genes.R-HSA-4641265.Retinoid metabolism and transport.R-HSA-975634;Role of LAT2-NTAL-LAB on calcium mobilization.R-HSA-2730905 Signaling by ERBB2.R-HSA-1227986SDK interactions.R-HSA-373756,SHC1 events in ERBB4 signaling.R-HSA-12503471SLC-mediated transmembrane transport.R-HSA-4254071SLIT2:ROBO1 increases RHOA activity.R-HSA-8985586DSMAD2-SMAD3:SMAD4 heterotrimer regulates transcription.R-HSA-2173796?STING mediated induction of host immune responses.R-HSA-18349415SUMOylation of DNA methylation proteins.R-HSA-4655427-Scavenging by Class A Receptors.R-HSA-3000480!Selective autophagy.R-HSA-96638911Regulation of FZD by ubiquitination.R-HSA-46412639RUNX3 regulates YAP1-mediated transcription.R-HSA-8951671VRUNX1 regulates transcription of genes involved in interleukin signaling.R-HSA-8939247NRUNX1 regulates transcription of genes involved in WNT signaling.R-HSA-8939256/Noncanonical activation of NOTCH3.R-HSA-9017802NrCAM interactions.R-HSA-447038$O-linked glycosylation.R-HSA-5173105*Other semaphorin interactions.R-HSA-416700,PI3K events in ERBB2 signaling.R-HSA-1963642,PI3K events in ERBB4 signaling.R-HSA-1250342-PLCG1 events in ERBB2 signaling.R-HSA-1251932'PTK6 Regulates Cell Cycle.R-HSA-8849470CPTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.R-HSA-8849469Pexophagy.R-HSA-9664873)Plasma lipoprotein assembly.R-HSA-8963898PPost-translational modification: synthesis of GPI-anchored proteins.R-HSA-163125+Pre-NOTCH Processing in Golgi.R-HSA-1912420?Pre-NOTCH Processing in the Endoplasmic Reticulum.R-HSA-1912399&Pregnenolone biosynthesis.R-HSA-196108;Proton-coupled neutral amino acid transporters.R-HSA-428559%RA biosynthesis pathway.R-HSA-5365859YRUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs).R-HSA-8877330NRUNX1 regulates transcription of genes involved in BCR signaling.R-HSA-8939245Signaling by BMP.R-HSA-201451 Signaling by ERBB4.R-HSA-12363949Activation of Na-permeable kainate receptors.R-HSA-451307dAPEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway.R-HSA-5649702VLDL clearance.R-HSA-8964046&Visual phototransduction.R-HSA-2187338>YAP1- and WWTR1 (TAZ)-stimulated gene expression.R-HSA-2032785cGMP effects.R-HSA-4184573ABC-family proteins mediated transport.R-HSA-3825566ADP signalling through P2Y purinoceptor 1.R-HSA-4185926AKT phosphorylates targets in the cytosol.R-HSA-1983236AKT phosphorylates targets in the nucleus.R-HSA-1986930AKT-mediated inactivation of FOXO1A.R-HSA-211163JAbortive elongation of HIV-1 transcript in the absence of Tat.R-HSA-167242(Signaling by FGFR2 IIIa TM.R-HSA-88517089Acetylcholine Neurotransmitter Release Cycle.R-HSA-2646422Activated NTRK2 signals through CDK5.R-HSA-90328453Activated NTRK2 signals through PLCG1.R-HSA-9026527mActivated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.R-HSA-5625886@Activation of ATR in response to replication stress.R-HSA-176187AActivation of BAD and translocation to mitochondria .R-HSA-111447,Activation of BH3-only proteins.R-HSA-114452AActivation of IRF3-IRF7 mediated by TBK1-IKK epsilon.R-HSA-936964AActivation of NMDA receptors and postsynaptic events.R-HSA-4427557Ubiquitin-dependent degradation of Cyclin D.R-HSA-75815%Triglyceride biosynthesis.R-HSA-75109FTransport of vitamins, nucleosides, and related molecules.R-HSA-425397dTransport of nucleosides and free purine and pyrimidine bases across the plasma membrane.R-HSA-839366Signaling by FGFR2 amplification mutants.R-HSA-2023837(Signaling by FGFR2 fusions.R-HSA-88533332Signaling by FGFR3 fusions in cancer.R-HSA-8853334Signaling by GPCR.R-HSA-372790Signaling by NOTCH1 t(7(Striated Muscle Contraction.R-HSA-390522*Sulfur amino acid metabolism.R-HSA-1614635,Synthesis of Dolichyl-phosphate.R-HSA-446199<Synthesis of substrates in N-glycan biosythesis.R-HSA-446219EADORA2B mediated anti-inflammatory cytokines production.R-HSA-96608219TGF-beta receptor signaling activates SMADs.R-HSA-2173789WTGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).R-HSA-2173791\TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.R-HSA-5676594TTP53 Regulates Transcription of Genes Involved in Cytochrome C Release.R-HSA-6803204TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.R-HSA-6803205(Tight junction interactions.R-HSA-4200291Transcriptional Regulation by VENTX.R-HSA-8853884?Transport of connexins along the secretory pathway.R-HSA-190827:Transport of connexons to the plasma membrane.R-HSA-190872< :tRNA modification in the nucleus and cytosol.R-HSA-67823153Rev-mediated nuclear export of HIV RNA.R-HSA-165054,VxPx cargo-targeting to cilium.R-HSA-5620916*Nuclear import of Rev protein.R-HSA-1807466Organic cation-anion-zwitterion transport.R-HSA-549132VOxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.R-HSA-1234176<Export of Viral Ribonucleoproteins from Nucleus.R-HSA-168274mRNA Splicing.R-HSA-72172+mRNA Editing: A to I Conversion.R-HSA-75064'Effects of PIP2 hydrolysis.R-HSA-114508LEGR2 and SOX10-mediated initiation of Schwann cell myelination.R-HSA-9619665:Transport of the SLBP independent Mature mRNA.R-HSA-159227(Signaling by ROBO receptors.R-HSA-3761768Transport of the SLBP Dependant Mature mRNA.R-HSA-159230FDownregulation of SMAD2-3:SMAD4 transcriptional activity.R-HSA-2173795BTransport of Ribonucleoproteins into the Host Nucleus.R-HSA-168271JTransport of Mature mRNAs Derived from Intronless Transcripts.R-HSA-159234KTransport of Mature mRNA Derived from an Intronless Transcript.R-HSA-159231/Deadenylation-dependent mRNA decay.R-HSA-429914"Deadenylation of mRNA.R-HSA-4299472Suppression of phagosomal maturation.R-HSA-96376874Nuclear Pore Complex (NPC) Disassembly.R-HSA-3301854(Nuclear Envelope Breakdown.R-HSA-29807664Formation of editosomes by ADAR proteins.R-HSA-770421Negative regulation of MET activity.R-HSA-6807004:Listeria monocytogenes entry into host cells.R-HSA-8876384!Intra-Golgi traffic.R-HSA-6811438#MAPK6-MAPK4 signaling.R-HSA-5687128<Interactions of Rev with host cellular proteins.R-HSA-1772433Inhibition of nitric oxide production.R-HSA-9636249Methylation.R-HSA-156581Mitotic Anaphase.R-HSA-68882,Mitotic Metaphase and Anaphase.R-HSA-2555396)Mitotic Telophase-Cytokinesis.R-HSA-688843HuR (ELAVL1) binds and stabilizes mRNA.R-HSA-450520ANEP-NS2 Interacts with the Cellular Export Machinery.R-HSA-168333)HIV Transcription Initiation.R-HSA-167161HCMV Early Events.R-HSA-96096902NS1 Mediated Effects on Host Pathways.R-HSA-1682764Negative regulation of FGFR2 signaling.R-HSA-5654727=Gastrin-CREB signalling pathway via PKC and MAPK.R-HSA-8819074Negative regulation of FGFR3 signaling.R-HSA-5654732*RHO GTPases Activate Formins.R-HSA-5663220)mRNA Splicing - Major Pathway.R-HSA-72163Cell Cycle, Mitotic.R-HSA-69278Signaling by FGFR.R-HSA-190236+Cargo concentration in the ER.R-HSA-5694530Activation of RAC1.R-HSA-428540STAT5 Activation.R-HSA-9645135+RNA Polymerase II Transcription.R-HSA-738575Resolution of Sister Chromatid Cohesion.R-HSA-2500257ORNA Polymerase II Transcription Pre-Initiation And Promoter Opening.R-HSA-73779*Cellular response to hypoxia.R-HSA-12341746RNA Polymerase II Transcription Initiation.R-HSA-75953MRNA Polymerase II Transcription Initiation And Promoter Clearance.R-HSA-76042-RNA Polymerase II Promoter Escape.R-HSA-737762RNA Polymerase II HIV Promoter Escape.R-HSA-167162Rap1 signalling.R-HSA-3925174SUMOylation of transcription cofactors.R-HSA-3899300'C6 deamination of adenosine.R-HSA-75102GRegulation of gene expression by Hypoxia-inducible Factor.R-HSA-1234158-Separation of Sister Chromatids.R-HSA-2467813,Cohesin Loading onto Chromatin.R-HSA-24709465RNA Polymerase I Transcription Initiation.R-HSA-73762(SHC-mediated cascade:FGFR1.R-HSA-56546880Cap-dependent Translation Initiation.R-HSA-72737-Scavenging by Class B Receptors.R-HSA-3000471&Calmodulin induced events.R-HSA-1119336SUMOylation of ubiquitinylation proteins.R-HSA-3232142<Amino acid transport across the plasma membrane.R-HSA-352230SUMOylation.R-HSA-2990846aAmplification of signal from unattached kinetochores via a MAD2 inhibitory signal.R-HSA-141444(Calcineurin activates NFAT.R-HSA-2025928:Amplification of signal from the kinetochores.R-HSA-141424CaM pathway.R-HSA-1119972Autodegradation of Cdh1 by Cdh1:APC-C.R-HSA-174084;Cargo trafficking to the periciliary membrane.R-HSA-5620920NCREB1 phosphorylation through the activation of Adenylate Cyclase.R-HSA-442720 Ca-dependent events.R-HSA-111996"Signaling by SCF-KIT.R-HSA-1433557ACdc20:Phospho-APC-C mediated degradation of Cyclin A.R-HSA-174184%Dual incision in TC-NER.R-HSA-6782135/Role of ABL in ROBO-SLIT signaling.R-HSA-428890<Role of second messengers in netrin-1 signaling.R-HSA-4188905Downstream signaling of activated FGFR1.R-HSA-5654687BDownstream signaling events of B Cell Receptor (BCR).R-HSA-1168372%Downstream TCR signaling.R-HSA-2024247Detoxification of Reactive Oxygen Species.R-HSA-32996851SUMOylation of RNA binding proteins.R-HSA-4570464#DAG and IP3 signaling.R-HSA-1489509PCooperation of Prefoldin and TriC-CCT in actin and tubulin folding.R-HSA-389958PCooperation of PDCL (PhLP1) and TRiC-CCT in G-protein beta folding.R-HSA-6814122GConversion from APC-C:Cdc20 to APC-C:Cdh1 in late anaphase.R-HSA-176407Circadian Clock.R-HSA-400253AActivation, translocation and oligomerization of BAX.R-HSA-1142940Chaperonin-mediated protein folding.R-HSA-3904661Adenylate cyclase activating pathway.R-HSA-1706605Activation of AMPK downstream of NMDARs.R-HSA-9619483+Sema4D in semaphorin signaling.R-HSA-4006851Sensing of DNA Double Strand Breaks.R-HSA-5693548HE2F-enabled inhibition of pre-replication complex formation.R-HSA-113507mRNA Capping.R-HSA-72086"mRNA 3'-end processing.R-HSA-721875Uptake and function of diphtheria toxin.R-HSA-53364154Uptake and actions of bacterial toxins.R-HSA-5339562Signaling by MST1.R-HSA-8852405BSignaling by NOTCH1 HD+PEST Domain Mutants in Cancer.R-HSA-2894858ATranscriptional regulation of pluripotent stem cells.R-HSA-4527231Transcriptional regulation by RUNX3.R-HSA-8878159HTranscriptional activity of SMAD2-SMAD3:SMAD4 heterotrimer.R-HSA-21737930Transcriptional Regulation by TP53.R-HSA-37009899Toxicity of botulinum toxin type B (BoNT-B).R-HSA-5250958?Signaling by NOTCH1 PEST Domain Mutants in Cancer.R-HSA-2644602!Signaling by NOTCH1.R-HSA-1980143OSignaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).R-HSA-2404192!Signaling by Leptin.R-HSA-2586552>APC-C-mediated degradation of cell cycle proteins.R-HSA-1741439APC-C:Cdc20 mediated degradation of Cyclin B.R-HSA-174048;Activated NTRK2 signals through FRS2 and FRS3.R-HSA-9028731OActivation, myristolyation of BID and translocation to mitochondria.R-HSA-75108rActivation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.R-HSA-72662YActivation of APC-C and APC-C:Cdc20 mediated degradation of mitotic proteins.R-HSA-176814.Signaling by TGFB family members.R-HSA-9006936Activation of AKT2.R-HSA-1651581Activated NTRK2 signals through FYN.R-HSA-9032500+Signaling by FGFR2 in disease.R-HSA-56552536Acetylcholine regulates insulin secretion.R-HSA-3999978APC-C:Cdc20 mediated degradation of Securin.R-HSA-174154XAbasic sugar-phosphate removal via the single-nucleotide replacement pathway.R-HSA-73930%ARMS-mediated activation.R-HSA-170984 Signaling by FGFR2.R-HSA-5654738tAPC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint.R-HSA-179419#Signaling by Hedgehog.R-HSA-53583514APC-Cdc20 mediated degradation of Nek2A.R-HSA-179409uAPC-C:Cdh1 mediated degradation of Cdc20 and other APC-C:Cdh1 targeted proteins in late mitosis-early G1.R-HSA-174178AAPC-C:Cdc20 mediated degradation of mitotic proteins.R-HSA-1764097E2F mediated regulation of DNA replication.R-HSA-113510VLRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.R-HSA-31349738EML4 and NUDC in mitotic spindle formation.R-HSA-9648025`RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.R-HSA-8939243PSLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.R-HSA-775887SCF-beta-TrCP mediated degradation of Emi1.R-HSA-174113:Ribosomal scanning and start codon recognition.R-HSA-72702aResolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).R-HSA-5693554UResolution of D-loop Structures through Holliday Junction Intermediates.R-HSA-5693568-Resolution of< D-Loop Structures.R-HSA-5693537-Regulation of mitotic cell cycle.R-HSA-453276,Regulation of TP53 Degradation.R-HSA-68047579Regulation of RUNX1 Expression and Activity.R-HSA-8934593KRegulation of APC-C activators between G1-S and early anaphase.R-HSA-176408FRUNX1 regulates estrogen receptor mediated transcription.R-HSA-8931987,RORA activates gene expression.R-HSA-1368082$SOS-mediated signalling.R-HSA-112412'ROBO receptors bind AKAP5.R-HSA-9010642,RNA Polymerase III Transcription.R-HSA-741588RNA Polymerase III Transcription Termination.R-HSA-739807RNA Polymerase III Transcription Initiation.R-HSA-76046LRNA Polymerase III Transcription Initiation From Type 3 Promoter.R-HSA-76071LRNA Polymerase III Transcription Initiation From Type 2 Promoter.R-HSA-76066LRNA Polymerase III Transcription Initiation From Type 1 Promoter.R-HSA-76061/RNA Polymerase III Chain Elongation.R-HSA-73780BRNA Polymerase III Abortive And Retractive Initiation.R-HSA-7494766RNA Polymerase II Transcription Elongation.R-HSA-759554Processing of Capped Intronless Pre-mRNA.R-HSA-75067=SLBP independent Processing of Histone Pre-mRNAs.R-HSA-1113675SUMOylation of DNA replication proteins.R-HSA-46158858Establishment of Sister Chromatid Cohesion.R-HSA-24680528rRNA processing in the nucleus and cytosol.R-HSA-8868773PTransport of inorganic cations-anions and amino acids-oligopeptides.R-HSA-425393RTransport of Mature mRNA derived from an Intron-Containing Transcript.R-HSA-1592367Transport of Mature Transcript to Cytoplasm.R-HSA-72202DTranslocation of SLC2A4 (GLUT4) to the plasma membrane.R-HSA-14451480Vpr-mediated nuclear import of PICs.R-HSA-180910*Translesion Synthesis by POLH.R-HSA-1103204Translation initiation complex formation.R-HSA-726490Transcriptional Regulation by E2F6.R-HSA-8953750GTranscription-Coupled Nucleotide Excision Repair (TC-NER).R-HSA-6781827,Transcription of the HIV genome.R-HSA-167172RTranscription of E2F targets under negative control by DREAM complex.R-HSA-1362277p38MAPK events.R-HSA-171007rRNA processing.R-HSA-72312 Signaling by FGFR1.R-HSA-5654736snRNP Assembly.R-HSA-191859TTP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.R-HSA-6804114>TP53 Regulates Transcription of DNA Repair Genes.R-HSA-6796648.TET1,2,3 and TDG demethylate DNA.R-HSA-5221030DAssembly of the ORC complex at the origin of replication.R-HSA-68616:Synthesis of IP2, IP, and Ins in the cytosol.R-HSA-1855183.Spry regulation of FGF signaling.R-HSA-12955965Small interfering RNA (siRNA) biogenesis.R-HSA-426486;Signaling by activated point mutants of FGFR1.R-HSA-18391224Signaling by Receptor Tyrosine Kinases.R-HSA-9006934;Processing of Capped Intron-Containing Pre-mRNA.R-HSA-72203MPresynaptic phase of homologous DNA pairing and strand exchange.R-HSA-56936169Post-transcriptional silencing by small RNAs.R-HSA-4264968Free fatty acids regulate insulin secretion.R-HSA-400451=Initiation of Nuclear Envelope (NE) Reformation.R-HSA-2995383Inhibition of the proteolytic activity of APC-C required for the onset of anaphase by mitotic spindle checkpoint components.R-HSA-141405 Infectious disease.R-HSA-5663205MInactivation of APC-C via direct inhibition of the APC-C complex.R-HSA-1414303IRS-related events triggered by IGF1R.R-HSA-2428928$IRS-mediated signalling.R-HSA-112399-Host Interactions of HIV factors.R-HSA-1629098Homologous DNA Pairing and Strand Exchange.R-HSA-5693579HIV Life Cycle.R-HSA-162587HIV Infection.R-HSA-1629068HDR through Homologous Recombination (HRR).R-HSA-5685942EGap-filling DNA repair synthesis and ligation in TC-NER.R-HSA-6782210OFormation of the ternary complex, and subsequently, the 43S complex.R-HSA-72695)Phosphorylation of the APC-C.R-HSA-1764126Formation of TC-NER Pre-Incision Complex.R-HSA-6781823)Folding of actin by CCT-TriC.R-HSA-390450*FRS-mediated FGFR3 signaling.R-HSA-5654706*FRS-mediated FGFR2 signaling.R-HSA-5654700*FRS-mediated FGFR1 signaling.R-HSA-56546932FGFRL1 modulation of FGFR1 signaling.R-HSA-5658623=Retrograde transport at the Trans-Golgi-Network.R-HSA-68114401FGFR1b ligand binding and activation.R-HSA-1903700FGFR1 ligand binding and activation.R-HSA-190242-FCERI mediated NF-kB activation.R-HSA-2871837-Eukaryotic Translation Initiation.R-HSA-72613"Estrogen biosynthesis.R-HSA-193144+Inositol phosphate metabolism.R-HSA-1483249Insulin processing.R-HSA-264876<Interactions of Vpr with host cellular proteins.R-HSA-176033#Intestinal absorption.R-HSA-89636765Phospholipase C-mediated cascade: FGFR1.R-HSA-56542191PKA-mediated phosphorylation of CREB.R-HSA-111931PKA activation.R-HSA-1636152PKA activation in glucagon signalling.R-HSA-164378PI3K Cascade.R-HSA-109704!PI-3K cascade:FGFR1.R-HSA-5654689%Organic cation transport.R-HSA-549127.Nuclear Envelope (NE) Reassembly.R-HSA-29954104Negative regulation of FGFR4 signaling.R-HSA-56547334Negative regulation of FGFR1 signaling.R-HSA-56547268NR1D1 (REV-ERBA) represses gene expression.R-HSA-1368071&Mitotic Spindle Checkpoint.R-HSA-69618 Mitotic Prometaphase.R-HSA-68877)Metabolism of non-coding RNA.R-HSA-194441Metabolism of RNA.R-HSA-8953854KMajor pathway of rRNA processing in the nucleolus and cytosol.R-HSA-6791226)MET activates RAP1 and RAC1.R-HSA-8875555%MET Receptor Activation.R-HSA-6806942)Late Phase of HIV Life Cycle.R-HSA-1625995KSRP (KHSRP) binds and destabilizes mRNA.R-HSA-450604*Intestinal hexose absorption.R-HSA-89813731FGFR1c ligand binding and activation.R-HSA-190373ETristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.R-HSA-4505135PIWI-interacting RNA (piRNA) biogenesis.R-HSA-5601884PPOU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.R-HSA-2892247QPOU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation.R-HSA-2892245"PTK6 Down-Regulation.R-HSA-8849472PTK6 Expression.R-HSA-8849473@PTK6 Regulates Proteins Involved in RNA Processing.R-HSA-8849468BConstitutive Signaling by NOTCH1 PEST Domain Mutants.R-HSA-2644606EConstitutive Signaling by NOTCH1 HD+PEST Domain Mutants.R-HSA-2894862/PTK6 promotes HIF1A stabilization.R-HSA-8857538(Peptide hormone metabolism.R-HSA-2980736 Phospholipase C-mediated cascade$Formation of apoptosome.R-HSA-111458+Plasma lipoprotein remodeling.R-HSA-8963899&Interleukin-37 signaling.R-HSA-9008059/Insulin receptor signalling cascade.R-HSA-74751!PI-3K cascade:FGFR2.R-HSA-5654695+PERK regulates gene expression.R-HSA-3810428Oligomerization of connexins into connexons.R-HSA-190704ANOTCH1 Intracellular Domain Regulates Transcription.R-HSA-2122947EEntry of Influenza Virion into Host Cell via Endocytosis.R-HSA-1682750EPHA-mediated growth cone collapse.R-HSA-3928663-EGFR Transactivation by Gastrin.R-HSA-21793925Downstream signaling of activated FGFR2.R-HSA-5654696&Digestion and absorption.R-HSA-8963743+Dermatan sulfate biosynthesis.R-HSA-20229233Fc epsilon receptor (FCERI) signaling.R-HSA-2454202-MET interacts with TNS proteins.R-HSA-8875513,Notch-HLH transcription pathway.R-HSA-3500545Cytochrome c-mediated apoptotic response.R-HSA-111461OCross-presentation of particulate exogenous antigens (phagosomes).R-HSA-1236973.Chondroitin sulfate biosynthesis.R-HSA-2022870%NOD1-2 Signaling Pathway.R-HSA-168638HCN channels.R-HSA-1296061JButyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.R-HSA-4503853Regulation of the apoptosome activity.R-HSA-96270695Generation of second messenger molecules.R-HSA-202433.Regulation of signaling by NODAL.R-HSA-1433617+Inactivation of CDC42 and RAC1.R-HSA-4285434IRF3 mediated activation of type 1 IFN.R-HSA-16063417CLEC7A (Dectin-1) induces NFAT activation.R-HSA-5607763PRegulation of mRNA stability by proteins that bind AU-rich elements.R-HSA-4505318Regulation of lipid metabolism by PPARalpha.R-HSA-4002060Regulation of gap junction activity.R-HSA-191650.Growth hormone receptor signaling.R-HSA-9827726Alpha-protein kinase 1 signaling pathway.R-HSA-9645460HCMV Late Events.R-HSA-9610379HRegulation of FOXO transcriptional activity by acetylation.R-HSA-9617629< )Regulation of KIT signaling.R-HSA-14335591Hypusine synthesis from eIF5A-lysine.R-HSA-2046263RHO GTPases regulate CFTR trafficking.R-HSA-5627083:Response of EIF2AK1 (HRI) to heme deficiency.R-HSA-9648895RAF activation.R-HSA-5673000CS-DS degradation.R-HSA-20241014Gap junction trafficking and regulation.R-HSA-157858 Influenza Infection.R-HSA-168255NATF4 activates genes in response to endoplasmic reticulum stress.R-HSA-380994-Response of Mtb to phagocytosis.R-HSA-9637690AResponse of EIF2AK4 (GCN2) to amino acid deficiency.R-HSA-9633012Inhibition of PKR.R-HSA-169131)HDR through MMEJ (alt-NHEJ).R-HSA-5685939"Gene Silencing by RNA.R-HSA-2110001FGFR2c ligand binding and activation.R-HSA-190375%Death Receptor Signalling.R-HSA-73887:TICAM1, RIP1-mediated IKK complex recruitment.R-HSA-168927<Cyclin A:Cdk2-associated events at S phase entry.R-HSA-69656,Cyclin D associated events in G1.R-HSA-69231>TICAM1,TRAF6-dependent induction of TAK1 complex.R-HSA-9014325.DCC mediated attractive signaling.R-HSA-418885>Cyclin E associated events during G1-S transition .R-HSA-69202_TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.R-HSA-88669109Cytochrome P450 - arranged by substrate type.R-HSA-211897TCR signaling.R-HSA-202403(FGFR2 alternative splicing.R-HSA-6803529;Cytosolic sensors of pathogen-associated DNA .R-HSA-18349498Synthesis of very long-chain fatty acyl-CoAs.R-HSA-75876'Digestion of dietary lipid.R-HSA-192456*Erythropoietin activates RAS.R-HSA-9027284/Sphingolipid de novo biosynthesis.R-HSA-1660661;Downregulation of TGF-beta receptor signaling.R-HSA-21737885Downstream signaling of activated FGFR3.R-HSA-5654708-EPHB-mediated forward signaling.R-HSA-3928662?Stimulation of the cell death response by PAK-2p34.R-HSA-211736$Sphingolipid metabolism.R-HSA-428157 Stabilization of p53.R-HSA-69541 Degradation of DVL.R-HSA-4641258.FGFR1 mutant receptor activation.R-HSA-1839124,FCGR3A-mediated IL10 synthesis.R-HSA-9664323Endogenous sterols.R-HSA-211976(Dimerization of procaspase-8.R-HSA-69416.Eukaryotic Translation Termination.R-HSA-72764MSynthesis of bile acids and bile salts via 27-hydroxycholesterol.R-HSA-193807.Eukaryotic Translation Elongation.R-HSA-156842,Erythropoietin activates STAT5.R-HSA-9027283Disease.R-HSA-1643685.Synaptic adhesion-like molecules.R-HSA-8849932)Regulation of TP53 Activity.R-HSA-5633007;Constitutive Signaling by Overexpressed ERBB2.R-HSA-9634285"VEGFA-VEGFR2 Pathway.R-HSA-44200973Uptake and function of anthrax toxins.R-HSA-5210891:rRNA modification in the nucleus and cytosol.R-HSA-6790901VTransport of bile salts and organic acids, metal ions and amine compounds.R-HSA-425366:ALKBH3 mediated reversal of alkylation damage.R-HSA-1121260VEGFR2 mediated cell proliferation.R-HSA-5218921&AURKA Activation by TPX2.R-HSA-88545181Activated NTRK2 signals through RAS.R-HSA-90265191Activated NTRK3 signals through RAS.R-HSA-90348648Activation of Ca-permeable Kainate Receptor.R-HSA-4513080Activation of NF-kappaB in B cells.R-HSA-1169091Translation.R-HSA-72766DActivation of PPARGC1A (PGC-1alpha) by phosphorylation.R-HSA-21512093VEGFR2 mediated vascular permeability.R-HSA-5218920(Anchoring fibril formation.R-HSA-22143209ZBP1(DAI) mediated induction of type I IFNs.R-HSA-1606322-Vitamin C (ascorbate) metabolism.R-HSA-196836)mRNA Splicing - Minor Pathway.R-HSA-72165eNOS activation.R-HSA-203615Lalpha-linolenic (omega3) and linoleic (omega6) acid metabolism.R-HSA-2046104(Vesicle-mediated transport.R-HSA-5653656#Viral mRNA Translation.R-HSA-1928232rRNA processing in the mitochondrion.R-HSA-88687662tRNA processing in the mitochondrion.R-HSA-6785470JTranscriptional regulation of white adipocyte differentiation.R-HSA-381340@Anchoring of the basal body to the plasma membrane.R-HSA-5620912NConstitutive Signaling by Ligand-Responsive EGFR Cancer Variants.R-HSA-12363828CDC6 association with the ORC:origin complex.R-HSA-686890FGFR3 ligand binding and activation.R-HSA-190239ITP53 Regulates Transcription of Death Receptors and Ligands.R-HSA-6803211>TP53 Regulates Transcription of Cell Cycle Genes.R-HSA-6791312,TP53 Regulates Metabolic Genes.R-HSA-5628897/TNFR2 non-canonical NF-kB pathway.R-HSA-56685414Cellular responses to external stimuli.R-HSA-8953897*Cellular responses to stress.R-HSA-2262752"Centrosome maturation.R-HSA-380287=Chondroitin sulfate-dermatan sulfate metabolism.R-HSA-1793185Cilium Assembly.R-HSA-5617833TNF signaling.R-HSA-758936Condensation of Prometaphase Chromosomes.R-HSA-25148530Constitutive Signaling by EGFRvIII.R-HSA-5637810(CD28 dependent Vav1 pathway.R-HSA-389359TRAIL signaling.R-HSA-75158DTranscriptional activation of mitochondrial biogenesis.R-HSA-2151201vTranscription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.R-HSA-13623006Transcription from mitochondrial promoters.R-HSA-75944PAnti-inflammatory response favouring Leishmania parasite infection.R-HSA-9662851;The retinoid cycle in cones (daylight vision).R-HSA-2187335)CASP8 activity is inhibited.R-HSA-52189007BBSome-mediated cargo-targeting to cilium.R-HSA-5620922TTetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.R-HSA-1474151CBMAL1:CLOCK,NPAS2 activates circadian gene expression.R-HSA-1368108/Bile acid and bile salt metabolism.R-HSA-194068.Blood group systems biosynthesis.R-HSA-90336580Branched-chain amino acid catabolism.R-HSA-708951TYSND1 cleaves peroxisomal proteins.R-HSA-9033500~TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.R-HSA-6804115Signaling by VEGF.R-HSA-194138ISRP-dependent cotranslational protein targeting to membrane.R-HSA-17993393Nuclear Receptor transcription pathway.R-HSA-383280hNucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways.R-HSA-1686432Organelle biogenesis and maintenance.R-HSA-1852241<PCNA-Dependent Long Patch Base Excision Repair.R-HSA-5651801,SHC1 events in ERBB2 signaling.R-HSA-12501963SHC-related events triggered by IGF1R.R-HSA-2428933(SHC-mediated cascade:FGFR3.R-HSA-56547046SCF(Skp2)-mediated degradation of p27-p21.R-HSA-187577PD-1 signaling.R-HSA-389948!PI-3K cascade:FGFR3.R-HSA-5654710%PLC beta mediated events.R-HSA-112043;POLB-Dependent Long Patch Base Excision Repair.R-HSA-110362-PPARA activates gene expression.R-HSA-1989781%Peptide chain elongation.R-HSA-156902*Nonsense-Mediated Decay (NMD).R-HSA-927802YNonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).R-HSA-975956Signalling to RAS.R-HSA-167044VNonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).R-HSA-975957#Mitotic G2-G2-M phases.R-HSA-4532742NCAM signaling for neurite out-growth.R-HSA-375165NCAM1 interactions.R-HSA-419037.NOSTRIN mediated eNOS trafficking.R-HSA-203641QNegative regulation of NMDA receptor-mediated neuronal transmission.R-HSA-9617324-Scavenging by Class F Receptors.R-HSA-30004845Negative regulation of NOTCH4 signaling.R-HSA-9604323<SUMOylation of chromatin organization proteins.R-HSA-4551638DSUMOylation of DNA damage response and repair proteins.R-HSA-3108214/SUMO is proteolytically processed.R-HSA-3065679Netrin-1 signaling.R-HSA-3737527SUMO E3 ligases SUMOylate target proteins.R-HSA-3108232ePhosphorylation of proteins involved in G1-S transition by active Cyclin E:Cdk2 complexes.R-HSA-69200$Plasmalogen biosynthesis.R-HSA-75896*Platelet sensitization by LDL.R-HSA-4321428Regulation of ornithine decarboxylase (ODC).R-HSA-3505628Receptor-type tyrosine-protein phosphatases.R-HSA-3888442Regulation of necroptotic cell death.R-HSA-5675482MRecognition of DNA damage by PCNA-containing replication complex.R-HSA-1103147Recruitment of NuMA to mitotic centrosomes.R-HSA-380320ERecruitment of mitotic centrosome proteins and complexes.R-HSA-3802709Regulation of expression of SLITs and ROBOs.R-HSA-9010553.Recycling of bile acids and salts.R-HSA-159418"Regulation by c-FLIP.R-HSA-< 3371378$Regulation of Apoptosis.R-HSA-169911HRegulation of commissural axon pathfinding by SLIT and ROBO.R-HSA-428542<Regulation of PAK-2p34 activity by PS-GAP-RHG10.R-HSA-211728<Regulation of PLK1 Activity at G2-M Transition.R-HSA-25659423Regulation of PTEN gene transcription.R-HSA-8943724'Regulation of RAS by GAPs.R-HSA-5658442+Regulation of TNFR1 signaling.R-HSA-5357905+Regulation of signaling by CBL.R-HSA-912631%RUNX3 regulates p14-ARF.R-HSA-89519367RNA Polymerase II Transcription Termination.R-HSA-73856.Processing of Intronless Pre-mRNAs.R-HSA-77595%RAB geranylgeranylation.R-HSA-8873719'RHO GTPases activate KTN1.R-HSA-5625970XRNA Pol II CTD phosphorylation and interaction with CE during HIV infection.R-HSA-167160BRNA Pol II CTD phosphorylation and interaction with CE.R-HSA-770757RNA Polymerase II Pre-transcription Events.R-HSA-674695-Rhesus blood group biosynthesis.R-HSA-9037628YResolution of AP sites via the multiple-nucleotide patch replacement pathway.R-HSA-1103737RNA polymerase II transcribes snRNA genes.R-HSA-6807505IRUNX1 regulates expression of components of tight junctions.R-HSA-8935964aRUNX1 regulates transcription of genes involved in differentiation of keratinocytes.R-HSA-8939242)Selenoamino acid metabolism.R-HSA-2408522&Selenocysteine synthesis.R-HSA-2408557%Interleukin-7 signaling.R-HSA-1266695GHSP90 chaperone cycle for steroid hormone receptors (SHR).R-HSA-3371497Signaling by PTK6.R-HSA-8848021"Hedgehog 'off' state.R-HSA-56107878Signaling by Non-Receptor Tyrosine Kinases.R-HSA-9006927Signaling by MET.R-HSA-6806834DSignaling by Ligand-Responsive EGFR Variants in Cancer.R-HSA-5637815)Signaling by Insulin receptor.R-HSA-74752&Homology Directed Repair.R-HSA-5693538 Signaling by Hippo.R-HSA-2028269 Signaling by FGFR3.R-HSA-56547418Signaling by FGFR3 point mutants in cancer.R-HSA-8853338+Signaling by FGFR3 in disease.R-HSA-5655332%IGF1R signaling cascade.R-HSA-2428924+Signaling by FGFR1 in disease.R-HSA-5655302>Influenza Viral RNA Transcription and Replication.R-HSA-1682733Signaling by TGF-beta Receptor Complex.R-HSA-1708347HDR through Single Strand Annealing (SSA).R-HSA-5685938G1 Phase.R-HSA-692361FGFR3c ligand binding and activation.R-HSA-1903728Signaling by plasma membrane FGFR1 fusions.R-HSA-8853336RFactors involved in megakaryocyte development and platelet production.R-HSA-9832319Signaling by cytosolic FGFR1 fusion mutants.R-HSA-18391174Formation of a pool of free 40S subunits.R-HSA-72689&G-protein mediated events.R-HSA-112040G0 and Early G1.R-HSA-1538133YHDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).R-HSA-5693567G2-M Transition.R-HSA-69275;Signaling by activated point mutants of FGFR3.R-HSA-1839130GAB1 signalosome.R-HSA-180292,GRB2 events in ERBB2 signaling.R-HSA-1963640CGTP hydrolysis and joining of the 60S ribosomal subunit.R-HSA-727060Golgi Associated Vesicle Biogenesis.R-HSA-432722;Regulation of TP53 Expression and Degradation.R-HSA-68060032Interaction between PHLDA1 and AURKA.R-HSA-8854521<Intra-Golgi and retrograde Golgi-to-ER traffic.R-HSA-68114423Mitochondrial transcription initiation.R-HSA-1632826Signaling by FGFR1 amplification mutants.R-HSA-1839120.MET activates PI3K-AKT signaling.R-HSA-8851907*MET activates PTK2 signaling.R-HSA-8874081"MET activates PTPN11.R-HSA-8865999)MET activates RAS signaling.R-HSA-8851805(MET promotes cell motility.R-HSA-8875878!Membrane Trafficking.R-HSA-199991Signal attenuation.R-HSA-747495Metabolism of amino acids and derivatives.R-HSA-71291$Sialic acid metabolism.R-HSA-4085001GMetabolism of nitric oxide: NOS3 activation and regulation.R-HSA-202131%Metabolism of polyamines.R-HSA-351202#Metabolism of proteins.R-HSA-392499$Metabolism of steroids.R-HSA-8957322$Semaphorin interactions.R-HSA-373755HSema4D mediated inhibition of cell attachment and migration.R-HSA-4165500Sema3A PAK dependent Axon repulsion.R-HSA-399954&Mitochondrial biogenesis.R-HSA-1592230Lysine catabolism.R-HSA-71064bLoss of proteins required for interphase microtubule organization from the centrosome.R-HSA-380284*Signaling by ERBB2 in Cancer.R-HSA-1227990PIntracellular metabolism of fatty acids regulates insulin secretion.R-HSA-434313&Intraflagellar transport.R-HSA-56209245Ionotropic activity of kainate receptors.R-HSA-451306aJNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.R-HSA-450321*Signaling by FGFR in disease.R-HSA-1226099)Signaling by Erythropoietin.R-HSA-9006335"Josephin domain DUBs.R-HSA-5689877Kinesins.R-HSA-983189)Signaling by EGFR in Cancer.R-HSA-1643713NL13a-mediated translational silencing of Ceruloplasmin expression.R-HSA-156827#LGI-ADAM interactions.R-HSA-56829100Signaling by ERBB2 TMD-JMD mutants.R-HSA-96656865Leishmania parasite growth and survival.R-HSA-9664433Lipophagy.R-HSA-9613354+Signaling by ERBB2 KD Mutants.R-HSA-96645651Loss of Nlp from mitotic centrosomes.R-HSA-380259,Signaling by ERBB2 ECD mutants.R-HSA-9665348-Signaling by EGFRvIII in Cancer.R-HSA-5637812EAMPK inhibits chREBP transcriptional activation activity.R-HSA-163680(SHC-mediated cascade:FGFR2.R-HSA-56546994SUMOylation of intracellular receptors.R-HSA-4090294-Scavenging by Class H Receptors.R-HSA-3000497,Scavenging of heme from plasma.R-HSA-2168880:Signal regulatory protein family interactions.R-HSA-391160 Signaling by NODAL.R-HSA-1181150-O-linked glycosylation of mucins.R-HSA-913709(Other interleukin signaling.R-HSA-449836P2Y receptors.R-HSA-417957+Terminal pathway of complement.R-HSA-1666651Termination of O-glycan biosynthesis.R-HSA-977068VLDL assembly.R-HSA-8866423'Virus Assembly and Release.R-HSA-168268+WNT mediated activation of DVL.R-HSA-2016884tRNA modification in the mitochondrion.R-HSA-67874502Activated NTRK2 signals through PI3K.R-HSA-9028335)Activation of AMPA receptors.R-HSA-399710-Telomere Extension By Telomerase.R-HSA-171319JSodium-coupled sulphate, di- and tri-carboxylate transporters.R-HSA-433137&Stimuli-sensing channels.R-HSA-2672351#Surfactant metabolism.R-HSA-5683826<Synthesis of Leukotrienes (LT) and Eoxins (EX).R-HSA-2142691Synthesis of PA.R-HSA-1483166+Synthesis of diphthamide-EEF2.R-HSA-5358493iSynthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).R-HSA-400511-Creation of C4 and C2 activators.R-HSA-1667860FGFR2 ligand binding and activation.R-HSA-190241.FGFR2 mutant receptor activation.R-HSA-18391261FGFR2b ligand binding and activation.R-HSA-1903772Nectin-Necl trans heterodimerization.R-HSA-420597Acetylation.R-HSA-156582.Activated point mutants of FGFR2.R-HSA-2033519=Assembly of Viral Components at the Budding Site.R-HSA-168316!Cam-PDE 1 activation.R-HSA-1119577ChREBP activates metabolic gene expression.R-HSA-163765\Ficolins bind to repetitive carbohydrate structures on the target cell surface.R-HSA-2855086LDL remodeling.R-HSA-89640414Lectin pathway of complement activation.R-HSA-166662(Methionine salvage pathway.R-HSA-1237112NADPH regeneration.R-HSA-389542#Invadopodia formation.R-HSA-8941237'GPCR downstream signalling.R-HSA-388396@Activation of BMF and translocation to mitochondria.R-HSA-139910/Processing and activation of SUMO.R-HSA-3215018*Prolactin receptor signaling.R-HSA-1170546BRas activation upon Ca2+ influx through NMDA receptor.R-HSA-442982=Regulation of TP53 Activity through Methylation.R-HSA-68047600Neurotoxicity of clostridium toxins.R-HSA-168799TOrexin and neuropeptides FF and QRFP bind to their respective receptors.R-HSA-389397$Organic anion transport.R-HSA-561048.PAOs oxidise polyamines to amines.R-HSA-141334PDE3B signalling.R-HSA-165160!PI-3K cascade:FGFR4.R-HSA-5654720 PKB-mediated events.R-HSA-109703DPTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.R-HSA-88494719Toxicity of botulinum toxin type E (BoNT-E).R-HSA-52509929Toxicity of botulinum toxin type G (BoNT-G).R-HSA-5250989(SHC-mediated cascade:FGFR4.R-HSA-5654719=SUMO is transferred from E1 to E2 (UBE2I, UBC9).R-HSA-3065678<1SUMOylation of SUMOylation proteins.R-HSA-4085377 Signaling by FGFR4.R-HSA-5654743]CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling.R-HSA-4427425Downstream signaling of activated FGFR4.R-HSA-5654716*Activation of RAS in B cells.R-HSA-1169092$Amine Oxidase reactions.R-HSA-140179"Androgen biosynthesis.R-HSA-193048/Apoptotic factor-mediated response.R-HSA-1114713BDNF activates NTRK2 (TRKB) signaling.R-HSA-9024909GErythropoietin activates Phosphoinositide-3-kinase (PI3K).R-HSA-90272760FGFR4 ligand binding and activation.R-HSA-1903220Interaction between L1 and Ankyrins.R-HSA-445095*Interconversion of polyamines.R-HSA-351200+Linoleic acid (LA) metabolism.R-HSA-2046105+Metabolism of steroid hormones.R-HSA-196071&Free fatty acid receptors.R-HSA-444209*FRS-mediated FGFR4 signaling.R-HSA-5654712JFatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.R-HSA-434316IRS activation.R-HSA-74713!Glycine degradation.R-HSA-67839840trans-Golgi Network Vesicle Budding.R-HSA-199992 InflammationDNA damage responseNeurodegeneration TranscriptionSupplementary Table 1. 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