ࡱ>  ZO\pVelisage 09 Ba== $\t@8X@"1Calibri1Calibri1Calibri1Calibri1Calibri1 Calibri1Calibri14Calibri1 Calibri1Calibri1Calibri1,6Calibri16Calibri16Calibri1>Calibri14Calibri1<Calibri1?Calibri1*h6 Calibri Light1Calibri1 Calibri"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_) #,##0\ "kr.";\-#,##0\ "kr."% #,##0\ "kr.";[Red]\-#,##0\ "kr."&!#,##0.00\ "kr.";\-#,##0.00\ "kr."+&#,##0.00\ "kr.";[Red]\-#,##0.00\ "kr."A<_-* #,##0\ "kr."_-;\-* #,##0\ "kr."_-;_-* "-"\ "kr."_-;_-@_-,'_-* #,##0_-;\-* #,##0_-;_-* "-"_-;_-@_-ID_-* #,##0.00\ "kr."_-;\-* #,##0.00\ "kr."_-;_-* "-"??\ "kr."_-;_-@_-4/_-* #,##0.00_-;\-* #,##0.00_-;_-* "-"??_-;_-@_-                                                                       ff         P@ @  P@ @  @       `@ @            a@ >   H1  H$  H5   ||B;R}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-} _-;_-* "}-} _-;_-* "}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef ?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L ?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A}  _-;_-* "23?\ "kr."}A}! _-;_-* "23 ?\ "kr."}A}" _-;_-* "?\ "kr."}A}# _-;_-* "?\ "kr."}A}$ _-;_-* "?\ "kr."}A}% _-;_-* "?\ "kr."}A}& _-;_-* "?\ "kr."}A}' _-;_-* " ?\ "kr."}A}( _-;_-* "?\ "kr."}}) }_-;_-* "?\ "kr."   }}* _-;_-* "?\ "kr."??? ??? ??? ???}-}+ _-;_-* "}-}, _-;_-* "}-}- _-;_-* "}-}. _-;_-* "}-}/ _-;_-* "}A}0 a_-;_-* "?\ "kr."}A}1 _-;_-* "?\ "kr."}A}2 _-;_-* "??\ "kr."}A}3 _-;_-* "23?\ "kr."}-}4 _-;_-* "}}5 ??v_-;_-* "̙?\ "kr."   }A}6 }_-;_-* "?\ "kr."}A}7 W_-;_-* "?\ "kr."}}8 _-;_-* "?\ "kr."   }}9 ???_-;_-* "?\ "kr."??? ??? ??? ???}-}: _-;_-* "}-}; _-;_-* "}U}< _-;_-* "?\ "kr." }-}= _-;_-* "}A}> _-;_-* "?\ "kr."}A}? _-;_-* "p0?\ "kr."}A}@ _-;_-* "?\ "kr."}-}A _-;_-* " 20% - Accent1M 20% - Accent1 ef % 20% - Accent2M" 20% - Accent2 ef % 20% - Accent3M& 20% - Accent3 ef % 20% - Accent4M* 20% - Accent4 ef % 20% - Accent5M. 20% - Accent5 ef % 20% - Accent6M2 20% - Accent6  ef % 40% - Accent1M 40% - Accent1 L % 40% - Accent2M# 40% - Accent2 L˭ % 40% - Accent3M' 40% - Accent3 L % 40% - Accent4M+ 40% - Accent4 L % 40% - Accent5M/ 40% - Accent5 L % 40% - Accent6M3 40% - Accent6  L % 60% - Accent1M 60% - Accent1 23 % 60% - Accent2M$ 60% - Accent2 23 % 60% - Accent3M( 60% - Accent3 23 % 60% - Accent4M, 60% - Accent4 23f % 60% - Accent5M0 60% - Accent5 23 %! 60% - Accent6M4 60% - Accent6  23Ў % "Accent1AAccent1 Dr % #Accent2A!Accent2 }1 % $Accent3A%Accent3  % %Accent4A)Accent4  % &Accent5A-Accent5 [ % 'Accent6A1Accent6  pG %(Bad9Bad  %) Calculation Calculation  }% * Check Cell Check Cell  %????????? ???+ Comma,( Comma [0]-&Currency.. Currency [0]/Explanatory TextG5Explanatory Text % 0Good;Good  a%1 Heading 1G Heading 1 DTj%Dr2 Heading 2G Heading 2 DTj%?3 Heading 3G Heading 3 DTj%234 Heading 49 Heading 4 DTj% 5InputuInput ̙ ??v% 6 Linked CellK Linked Cell }% 7NeutralANeutral  W%3Normal % 8Noteb Note   9OutputwOutput  ???%????????? ???:$Percent ;Title1Title DTj% <TotalMTotal %DrDr= Warning Text? Warning Text %XTableStyleMedium2PivotStyleLight16`  group 2 up%-group_2_overlap_down_pathways5 group_2_overlap_up_pathways;5 -Hutchinson GilfordWerner syndromeidnum1SUMOylation of SUMOylation proteins.R-HSA-4085377-RNA Polymerase I Promoter Opening.R-HSA-73728!RHO GTPase Effectors.R-HSA-195258$Protein ubiquitination.R-HSA-8852135"Protein localization.R-HSA-96095076Processive synthesis on the lagging strand.R-HSA-69183AProcessive synthesis on the C-strand of the telomere.R-HSA-174414.Processing of Intronless Pre-mRNAs.R-HSA-775958Processing of DNA double-strand break ends.R-HSA-5693607;Processing of Capped Intron-Containing Pre-mRNA.R-HSA-72203MPresynaptic phase of homologous DNA pairing and strand exchange.R-HSA-56936165Pre-NOTCH Transcription and Translation.R-HSA-1912408@Postmitotic nuclear pore complex (NPC) reformation.R-HSA-9615933?Positive epigenetic regulation of rRNA expression.R-HSA-5250913 Polymerase switching.R-HSA-69091APolymerase switching on the C-strand of the telomere.R-HSA-174411!Platelet homeostasis.R-HSA-418346*Plasma lipoprotein clearance.R-HSA-8964043CPlasma lipoprotein assembly, remodeling, and clearance.R-HSA-174824ePhosphorylation of proteins involved in G1-S transition by active Cyclin E:Cdk2 complexes.R-HSA-69200$Phosphorylation of Emi1.R-HSA-176417'RHO GTPases activate PKNs.R-HSA-5625740*RNA Polymerase I Transcription.R-HSA-73864;Phosphate bond hydrolysis by NTPDase proteins.R-HSA-88508437RNA Polymerase II Transcription Termination.R-HSA-738568Regulation of lipid metabolism by PPARalpha.R-HSA-400206ERegulation of cholesterol biosynthesis by SREBP (SREBF).R-HSA-16558299Regulation of RUNX3 expression and activity.R-HSA-89418583Regulation of PTEN gene transcription.R-HSA-8943724<Regulation of PLK1 Activity at G2-M Transition.R-HSA-2565942ERecruitment of mitotic centrosome proteins and complexes.R-HSA-3802707Recruitment of NuMA to mitotic centrosomes.R-HSA-380320wRecruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.R-HSA-5693565MRecognition of DNA damage by PCNA-containing replication complex.R-HSA-1103148RUNX2 regulates osteoblast differentiation.R-HSA-8940973PRUNX2 regulates genes involved in differentiation of myeloid cells.R-HSA-8941333.RUNX2 regulates bone development.R-HSA-8941326aRUNX1 regulates transcription of genes involved in differentiation of myeloid cells.R-HSA-8939246aRUNX1 regulates transcription of genes involved in differentiation of keratinocytes.R-HSA-8939242XRUNX1 regulates transcription of genes involved in differentiation of HSCs.R-HSA-8939236cRUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.R-HSA-8936459`RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.R-HSA-8939243,RNA Polymerase III Transcription.R-HSA-741587RNA Polymerase III Transcription Initiation.R-HSA-76046%Phospholipid metabolism.R-HSA-1483257@PTK6 Regulates Proteins Involved in RNA Processing.R-HSA-8849468.MET activates PI3K-AKT signaling.R-HSA-8851907,Mitotic Metaphase and Anaphase.R-HSA-25553961Mitotic G1 phase and G1-S transition.R-HSA-453279Mitotic Anaphase.R-HSA-68882&Mitochondrial biogenesis.R-HSA-1592230EMismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).R-HSA-5358565DMismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).R-HSA-5358606Mismatch Repair.R-HSA-53585088Miscellaneous transport and binding events.R-HSA-5223345*Metallothioneins bind metals.R-HSA-5661231$Metabolism of steroids.R-HSA-8957322%Metabolism of nucleotides.R-HSA-15869)Metabolism of non-coding RNA.R-HSA-194441!Metabolism of lipids.R-HSA-556833Metabolism of RNA.R-HSA-8953854/MHC class II antigen presentation.R-HSA-2132295(MET promotes cell motility.R-HSA-8875878-MET interacts with TNS proteins.R-HSA-8875513!MET activates STAT3.R-HSA-8875791)MET activates RAS signaling.R-HSA-8851805"MET activates PTPN11.R-HSA-8865999#Mitotic G2-G2-M phases.R-HSA-453274 Mitotic Prometaphase.R-HSA-68877PTEN Regulation.R-HSA-6807070Mitotic Prophase.R-HSA-68875-PRC2 methylates histones and DNA.R-HSA-212300-PPARA activates gene expression.R-HSA-1989781;POLB-Dependent Long Patch Base Excision Repair.R-HSA-110362@PI and PC transport between ER and Golgi membranes.R-HSA-1483196<PCNA-Dependent Long Patch Base Excision Repair.R-HSA-5651801'Orc1 removal from chromatin.R-HSA-68949*Nuclear import of Rev protein.R-HSA-1807464Nuclear Pore Complex (NPC) Disassembly.R-HSA-3301854(Nuclear Envelope Breakdown.R-HSA-2980766*Nonsense-Mediated Decay (NMD).R-HSA-927802VNonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).R-HSA-9759576NoRC negatively regulates rRNA expression.R-HSA-427413ZNegative regulation of activity of TFAP2 (AP-2) family transcription factors.R-HSA-8866904?Negative epigenetic regulation of rRNA expression.R-HSA-5250941Neddylation.R-HSA-89516642NS1 Mediated Effects on Host Pathways.R-HSA-168276ANEP-NS2 Interacts with the Cellular Export Machinery.R-HSA-168333)Mitotic Telophase-Cytokinesis.R-HSA-68884&Mitotic Spindle Checkpoint.R-HSA-69618PRegulation of mRNA stability by proteins that bind AU-rich elements.R-HSA-450531?Removal of the Flap Intermediate from the C-strand.R-HSA-174437,Removal of the Flap Intermediate.R-HSA-69166JTransport of Mature mRNAs Derived from Intronless Transcripts.R-HSA-159234KTransport of Mature mRNA Derived from an Intronless Transcript.R-HSA-1592317Transport of Mature Transcript to Cytoplasm.R-HSA-72202_Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.R-HSA-110313*Translesion synthesis by REV1.R-HSA-110312+Translesion synthesis by POLK.R-HSA-5655862+Translesion synthesis by POLI.R-HSA-5656121*Translesion Synthesis by POLH.R-HSA-110320:Transcriptional regulation of granulopoiesis.R-HSA-9616222\Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.R-HSA-88642606Transcriptional regulation by small RNAs.R-HSA-55787491Transcriptional regulation by RUNX1.R-HSA-8878171DTranscriptional activation of mitochondrial biogenesis.R-HSA-21512011Transcriptional Regulation by MECP2.R-HSA-89869440Transcriptional Regulation by E2F6.R-HSA-8953750vTranscription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.R-HSA-1362300RTranscription of E2F targets under negative control by DREAM complex.R-HSA-1362277ATrafficking of myristoylated proteins to the cilium.R-HSA-56241386Termination of translesion DNA synthesis.R-HSA-5656169+Terminal pathway of complement.R-HSA-166665RTransport of Mature mRNA derived from an Intron-Containing Transcript.R-HSA-159236BTransport of Ribonucleoproteins into the Host Nucleus.R-HSA-168271YResolution of AP sites via the multiple-nucleotide patch replacement pathway.R-HSA-1103738Transport of the SLBP Dependant Mature mRNA.R-HSA-159230snRNP Assembly.R-HSA-191859;p75NTR negatively regulates cell cycle via SC1.R-HSA-1936706p53-Independent G1-S DNA damage checkpoint.R-HSA-69613/p53-Independent DNA Damage Response.R-HSA-69610p38MAPK events.R-HSA-171007mRNA Splicing.R-HSA-72172)mRNA Splicing - Major Pathway.R-HSA-72163mRNA Editing.R-HSA-75072"mRNA 3'-end processing.R-HSA-721878activated TAK1 mediates p38 MAPK activation.R-HSA-4503020Vpr-mediated nuclear import of PICs.R-HSA-180910.Vitamin D (calciferol) metabolism.R-HSA-196791IVasopressin regulates renal water homeostasis via Aquaporins.R-HSA-4320400VEGFR2 mediated cell proliferation.R-HSA-5218921Unwinding of DNA.R-HSA-176974CUbiquitin Mediated Degradation of Phosphorylated Cdc25A.R-HSA-69601UCH proteinases.R-HSA-5689603ETristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.R-HSA-450513:Transport of the SLBP independent Mature mRNA.R-HSA-159227!Telomere Maintenance.R-HSA-1575793Telomere C-strand synthesis initiation.R-HSA-1744309Telomere C-strand (Lagging Strand) Synthesis.R-HSA-1744173TRAF3-dependent IRF activation pathway.R-HSA-9182334SUMOylation of intracellular receptors.R-HSA-4090294<SUMOylation of chromatin organization proteins.R-HSA-45516381SUMOylation of RNA binding proteins.R-HSA-4570464< 5SUMOylation of DNA replication proteins.R-HSA-46158855SUMOylation of DNA methylation proteins.R-HSA-4655427DSUMOylation of DNA damage response and repair proteins.R-HSA-31082147SUMO E3 ligases SUMOylate target proteins.R-HSA-31082321SLIT2:ROBO1 increases RHOA activity.R-HSA-8985586NSEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.R-HSA-399955S Phase.R-HSA-692423Role of phospholipids in phagocytosis.R-HSA-2029485/Role of ABL in ROBO-SLIT signaling.R-HSA-4288903Rev-mediated nuclear export of HIV RNA.R-HSA-165054$Response to metal ions.R-HSA-56605265Resolution of Sister Chromatid Cohesion.R-HSA-2500257aResolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).R-HSA-5693554UResolution of D-loop Structures through Holliday Junction Intermediates.R-HSA-5693568-Resolution of D-Loop Structures.R-HSA-56935371Resolution of Abasic Sites (AP sites).R-HSA-739334SUMOylation of transcription cofactors.R-HSA-3899300SUMOylation.R-HSA-2990846!Selective autophagy.R-HSA-96638918Signaling by plasma membrane FGFR1 fusions.R-HSA-8853336/TNFR2 non-canonical NF-kB pathway.R-HSA-5668541BTLR3-mediated TICAM1-dependent programmed cell death.R-HSA-90139579TGF-beta receptor signaling activates SMADs.R-HSA-2173789_TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.R-HSA-8866910EADORA2B mediated anti-inflammatory cytokines production.R-HSA-9660821Synthesis of DNA.R-HSA-69239<Switching of origins to a post-replicative state.R-HSA-69052Signalling to RAS.R-HSA-167044(Signaling by Retinoic Acid.R-HSA-5362517$Semaphorin interactions.R-HSA-373755(Signaling by ROBO receptors.R-HSA-376176Signaling by MET.R-HSA-68068346Signaling by FGFR1 amplification mutants.R-HSA-1839120 Signaling by ERBB2.R-HSA-1227986*Signaling by ERBB2 in Cancer.R-HSA-1227990:Signal regulatory protein family interactions.R-HSA-391160-Separation of Sister Chromatids.R-HSA-24678131Sensing of DNA Double Strand Breaks.R-HSA-5693548*MET activates PTK2 signaling.R-HSA-8874081PI Metabolism.R-HSA-1483255%MET Receptor Activation.R-HSA-6806942#Developmental Biology.R-HSA-12667388Establishment of Sister Chromatid Cohesion.R-HSA-2468052*Erythropoietin activates RAS.R-HSA-90272845Epigenetic regulation of gene expression.R-HSA-2121658EML4 and NUDC in mitotic spindle formation.R-HSA-9648025?E3 ubiquitin ligases ubiquitinate target proteins.R-HSA-88666547E2F mediated regulation of DNA replication.R-HSA-1135105Displacement of DNA glycosylase by APEX1.R-HSA-110357!DNA strand elongation.R-HSA-69190DARPP-32 events.R-HSA-180024&DNA replication initiation.R-HSA-68952DNA methylation.R-HSA-5334118DNA Replication.R-HSA-69306*DNA Replication Pre-Initiation.R-HSA-69002DNA Repair.R-HSA-73894,DNA Double-Strand Break Repair.R-HSA-5693532.DNA Double Strand Break Response.R-HSA-5693606<Export of Viral Ribonucleoproteins from Nucleus.R-HSA-168274#Extension of Telomeres.R-HSA-180786,FCERI mediated MAPK activation.R-HSA-2871796$Fanconi Anemia Pathway.R-HSA-6783310HCMV Early Events.R-HSA-9609690%HATs acetylate histones.R-HSA-3214847.Glycerophospholipid biosynthesis.R-HSA-1483206GGlucagon-like Peptide-1 (GLP1) regulates insulin secretion.R-HSA-3816767Glucagon signaling in metabolic regulation.R-HSA-163359EGap-filling DNA repair synthesis and ligation in GG-NER.R-HSA-5696397:GLI3 is processed to GLI3R by the proteasome.R-HSA-5610785G2-M Transition.R-HSA-69275G2-M Checkpoints.R-HSA-69481G2 Phase.R-HSA-68911'G1-S-Specific Transcription.R-HSA-69205G1-S Transition.R-HSA-69206G1 Phase.R-HSA-69236G0 and Early G1.R-HSA-15381333G beta:gamma signalling through CDC42.R-HSA-8964616DNA Damage Bypass.R-HSA-73893,Cyclin D associated events in G1.R-HSA-69231(HDACs deacetylate histones.R-HSA-3214815aAmplification of signal from unattached kinetochores via a MAD2 inhibitory signal.R-HSA-1414443Assembly of the pre-replicative complex.R-HSA-68867DAssembly of the ORC complex at the origin of replication.R-HSA-68616)Aquaporin-mediated transport.R-HSA-445717%Apoptotic execution phase.R-HSA-751534Apoptotic cleavage of cellular proteins.R-HSA-111465PAnti-inflammatory response favouring Leishmania parasite infection.R-HSA-9662851:Amplification of signal from the kinetochores.R-HSA-141424$Adaptive Immune System.R-HSA-12802182Condensation of Prophase Chromosomes.R-HSA-22997185Activation of the pre-replicative complex.R-HSA-68962bActivation of anterior HOX genes in hindbrain development during early embryogenesis.R-HSA-5617472Activation of RAC1.R-HSA-4285405Activation of Matrix Metalloproteinases.R-HSA-1592389<Activation of HOX genes during differentiation.R-HSA-5619507@Activation of ATR in response to replication stress.R-HSA-176187&AURKA Activation by TPX2.R-HSA-8854518AB-WICH complex positively regulates rRNA expression.R-HSA-5250924 Base Excision Repair.R-HSA-73884Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.R-HSA-446193JButyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.R-HSA-4503856Condensation of Prometaphase Chromosomes.R-HSA-2514853,Cohesin Loading onto Chromatin.R-HSA-2470946BCobalamin (Cbl, vitamin B12) transport and metabolism.R-HSA-196741)Citric acid cycle (TCA cycle).R-HSA-71403#Chylomicron clearance.R-HSA-8964026"Chromosome Maintenance.R-HSA-73886$Chromatin organization.R-HSA-4839726)Chromatin modifying enzymes.R-HSA-3247509"Centrosome maturation.R-HSA-380287Cell Cycle.R-HSA-1640170&CRMPs in Sema3A signaling.R-HSA-399956)CLEC7A-inflammasome pathway.R-HSA-5660668=CDT1 association with the CDC6:ORC:origin complex.R-HSA-68827<CDK-mediated phosphorylation and removal of Cdc6.R-HSA-690178CDC6 association with the ORC:origin complex.R-HSA-68689HCMV Late Events.R-HSA-9610379%Dual Incision in GG-NER.R-HSA-5696400YHDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA).R-HSA-5693567bLoss of proteins required for interphase microtubule organization from the centrosome.R-HSA-380284$Leading Strand Synthesis.R-HSA-69109<Interactions of Vpr with host cellular proteins.R-HSA-1760338Homologous DNA Pairing and Strand Exchange.R-HSA-5693579<Interactions of Rev with host cellular proteins.R-HSA-177243&Homology Directed Repair.R-HSA-5693538:Listeria monocytogenes entry into host cells.R-HSA-88763841Loss of Nlp from mitotic centrosomes.R-HSA-380259LInhibition of replication initiation of damaged DNA by RB1-E2F1.R-HSA-113501$Lagging Strand Synthesis.R-HSA-69186AInhibition of Host mRNA Processing and RNA Silencing.R-HSA-168315 Influenza Infection.R-HSA-168255#MAPK6-MAPK4 signaling.R-HSA-5687128+Inactivation of CDC42 and RAC1.R-HSA-428543/Lysosphingolipid and LPA receptors.R-HSA-419408-Host Interactions of HIV factors.R-HSA-162909M Phase.R-HSA-68886@Interconversion of nucleotide di- and triphosphates.R-HSA-4999435Leishmania parasite growth and survival.R-HSA-96644335KSRP (KHSRP) binds and destabilizes mRNA.R-HSA-450604LDL clearance.R-HSA-89640387HDR through Single Strand Annealing (SSA).R-HSA-5685938)HDR through MMEJ (alt-NHEJ).R-HSA-56859398HDR through Homologous Recombination (HRR).R-HSA-5685942#Metabolism of proteins.R-HSA-392499MParadoxical activation of RAF signaling by kinase inactive BRAF.R-HSA-6802955(Peroxisomal protein import.R-HSA-9033241$Integration of provirus.R-HSA-162592;Inhibition of Signaling by Overexpressed EGFR.R-HSA-5638303MInactivation of APC-C via direct inhibition of the APC-C complex.R-HSA-141430>Influenza Viral RNA Transcription and Replication.R-HSA-1682731Mitotic Metaphase-Anaphase Transition.R-HSA-68881Inflammasomes.R-HSA-6223123Mitochondrial transcription initiation.R-HSA-163282 Infectious disease.R-HSA-5663205"Metalloprotease DUBs.R-HSA-5689901%Peptide chain elongation.R-HSA-156902Pexophagy.R-HSA-96648737Infection with Mycobacterium tuberculosis.R-HSA-96354867Phosphorylation of CD3 and TCR zeta chains.R-HSA-2024275Phase I - Functionalization of compounds.R-HSA-2< 11945?Metabolism of water-soluble vitamins and cofactors.R-HSA-196849(MicroRNA (miRNA) biogenesis.R-HSA-203927KInlA-mediated entry of Listeria monocytogenes into host cells.R-HSA-8876493'Minus-strand DNA synthesis.R-HSA-164516=Initiation of Nuclear Envelope (NE) Reformation.R-HSA-2995383JInlB-mediated entry of Listeria monocytogenes into host cell.R-HSA-8875360:MyD88 dependent cascade initiated on endosome.R-HSA-975155Inhibition of the proteolytic activity of APC-C required for the onset of anaphase by mitotic spindle checkpoint components.R-HSA-141405BMyD88:MAL(TIRAP) cascade initiated on plasma membrane.R-HSA-1660583Pausing and recovery of HIV elongation.R-HSA-167290@Pausing and recovery of Tat-mediated HIV elongation.R-HSA-167238)Phosphorylation of the APC-C.R-HSA-176412(Methionine salvage pathway.R-HSA-12371127MyD88 cascade initiated on plasma membrane.R-HSA-9758713Inhibition of nitric oxide production.R-HSA-96362491Mitochondrial calcium ion transport.R-HSA-89492155Modulation by Mtb of host immune system.R-HSA-9637628*Mitochondrial protein import.R-HSA-1268020!Innate Immune System.R-HSA-168249^Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs-IMPs-VICKZs) bind RNA.R-HSA-428359'Mitochondrial translation.R-HSA-5368287Immune System.R-HSA-168256)Platelet calcium homeostasis.R-HSA-418360/RIPK1-mediated regulated necrosis.R-HSA-5213460Protein repair.R-HSA-5676934Purine catabolism.R-HSA-74259=Purinergic signaling in leishmaniasis infection.R-HSA-9660826;Pyruvate metabolism and Citric Acid (TCA) cycle.R-HSA-71406Pyruvate metabolism.R-HSA-702683RAB GEFs exchange GTP for GDP on RABs.R-HSA-8876198%RAB geranylgeranylation.R-HSA-8873719$RAF-MAP kinase cascade.R-HSA-5673001*RHO GTPases Activate Formins.R-HSA-5663220&RHO GTPases activate CIT.R-HSA-5625900)RHO GTPases activate IQGAPs.R-HSA-5626467.RMTs methylate histone arginines.R-HSA-3214858Protein folding.R-HSA-391251XRNA Pol II CTD phosphorylation and interaction with CE during HIV infection.R-HSA-167160BRNA Pol II CTD phosphorylation and interaction with CE.R-HSA-77075/RNA Polymerase I Promoter Clearance.R-HSA-73854,RNA Polymerase I Promoter Escape.R-HSA-737725RNA Polymerase I Transcription Initiation.R-HSA-737626RNA Polymerase I Transcription Termination.R-HSA-738632RNA Polymerase II HIV Promoter Escape.R-HSA-1671627RNA Polymerase II Pre-transcription Events.R-HSA-674695-RNA Polymerase II Promoter Escape.R-HSA-737766RNA Polymerase II Transcription Elongation.R-HSA-75955MRNA Polymerase II Transcription Initiation And Promoter Clearance.R-HSA-76042!Protein methylation.R-HSA-8876725(Prostanoid ligand receptors.R-HSA-391908*Platelet sensitization by LDL.R-HSA-4321424Post-chaperonin tubulin folding pathway.R-HSA-389977&Plus-strand DNA synthesis.R-HSA-164525%Metabolism of polyamines.R-HSA-3512022Mitochondrial translation elongation.R-HSA-5389840-Polo-like kinase mediated events.R-HSA-1567113IRF3-mediated induction of type I IFN.R-HSA-32706194IRF3 mediated activation of type 1 IFN.R-HSA-1606341'IRAK1 recruits IKK complex.R-HSA-9370392Mitochondrial translation initiation.R-HSA-5368286DIRAK1 recruits IKK complex upon TLR7-8 or 9 stimulation.R-HSA-975144=IL-6-type cytokine receptor ligand interactions.R-HSA-67884671Post NMDA receptor activation events.R-HSA-4380649Post-transcriptional silencing by small RNAs.R-HSA-426496BProstacyclin signalling through prostacyclin receptor.R-HSA-392851PPost-translational modification: synthesis of GPI-anchored proteins.R-HSA-1631254Post-translational protein modification.R-HSA-5975921Pre-NOTCH Expression and Processing.R-HSA-1912422BPrefoldin mediated transfer of substrate to CCT-TriC.R-HSA-3899576Presynaptic function of Kainate receptors.R-HSA-5006577Prevention of phagosomal-lysosomal fusion.R-HSA-9636383/Processing and activation of SUMO.R-HSA-32150184Processing of Capped Intronless Pre-mRNA.R-HSA-75067!Processing of SMDT1.R-HSA-8949664#Programmed Cell Death.R-HSA-5357801*Prolactin receptor signaling.R-HSA-1170546'Packaging Of Telomere Ends.R-HSA-171306%PLC beta mediated events.R-HSA-112043'PTK6 Regulates Cell Cycle.R-HSA-8849470(Nucleotide Excision Repair.R-HSA-5696398(Neurodegenerative Diseases.R-HSA-8863678JNR1H2 & NR1H3 regulate gene expression linked to lipogenesis.R-HSA-90295580Neurotoxicity of clostridium toxins.R-HSA-168799&Neutrophil degranulation.R-HSA-6798695ANOTCH3 Intracellular Domain Regulates Transcription.R-HSA-9013508L1CAM interactions.R-HSA-373760/Noncanonical activation of NOTCH3.R-HSA-9017802NL13a-mediated translational silencing of Ceruloplasmin expression.R-HSA-156827.Nonhomologous End-Joining (NHEJ).R-HSA-5693571Kinesins.R-HSA-983189"Josephin domain DUBs.R-HSA-5689877YNonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).R-HSA-975956,Notch-HLH transcription pathway.R-HSA-350054.Nuclear Envelope (NE) Reassembly.R-HSA-2995410,Ion transport by P-type ATPases.R-HSA-936837,Intrinsic Pathway for Apoptosis.R-HSA-109606&Intraflagellar transport.R-HSA-5620924:Intracellular signaling by second messengers.R-HSA-9006925#Nucleobase catabolism.R-HSA-8956319<Intra-Golgi and retrograde Golgi-to-ER traffic.R-HSA-6811442ORNA Polymerase II Transcription Pre-Initiation And Promoter Opening.R-HSA-73779*Intestinal hexose absorption.R-HSA-8981373 Nucleosome assembly.R-HSA-774815(Nervous system development.R-HSA-9675108QNR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake .R-HSA-90315255Negative regulation of NOTCH4 signaling.R-HSA-9604323'MAP2K and MAPK activation.R-HSA-5674135<Na+-Cl- dependent neurotransmitter transporters.R-HSA-442660(Nef and signal transduction.R-HSA-1649443MASTL Facilitates Mitotic Progression.R-HSA-2465910,NTRK3 as a dependence receptor.R-HSA-96035055NRIF signals cell death from the nucleus.R-HSA-205043_NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux.R-HSA-90295694Negative regulation of FGFR1 signaling.R-HSA-5654726#MAPK1-MAPK3 signaling.R-HSA-5684996,MAPK family signaling cascades.R-HSA-56830578MAP3K8 (TPL2)-dependent MAPK1-3 activation.R-HSA-5684264"MAP kinase activation.R-HSA-4502940NR1H2 and NR1H3-mediated signaling.R-HSA-9024446)Lipid particle organization.R-HSA-8964572"Leishmania infection.R-HSA-9658195+Late endosomal microautophagy.R-HSA-96157104Negative regulation of FGFR3 signaling.R-HSA-5654732MTOR signalling.R-HSA-1651591Negative regulation of MET activity.R-HSA-6807004)Late Phase of HIV Life Cycle.R-HSA-162599#LGI-ADAM interactions.R-HSA-5682910KMajor pathway of rRNA processing in the nucleolus and cytosol.R-HSA-6791226Meiosis.R-HSA-1500620#Intestinal absorption.R-HSA-8963676INOTCH3 Activation and Transmission of Signal to the Nucleus.R-HSA-9013507@Metabolism of ingested H2SeO4 and H2SeO3 into H2Se.R-HSA-2408550hNucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways.R-HSA-168643VOxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.R-HSA-1234176.PAOs oxidise polyamines to amines.R-HSA-141334VNF-kB activation through FADD-RIP-1 pathway mediated by caspase-8 and -10.R-HSA-933543NCAM1 interactions.R-HSA-419037PD-1 signaling.R-HSA-389948,Interferon alpha-beta signaling.R-HSA-909733PDE3B signalling.R-HSA-1651602NCAM signaling for neurite out-growth.R-HSA-375165*PIP3 activates AKT signaling.R-HSA-12576042PKA activation in glucagon signalling.R-HSA-164378!Interferon Signaling.R-HSA-913531PKA activation.R-HSA-1636151PKA-mediated phosphorylation of CREB.R-HSA-111931NADPH regeneration.R-HSA-3895425Metabolism of amino acids and derivatives.R-HSA-71291,NADE modulates death signalling.R-HSA-205025 PKB-mediated events.R-HSA-109703*Interconversion of polyamines.R-HSA-3512002Interaction between PHLDA1 and AURKA.R-HSA-8854521HN-glycan trimming in the ER and Calnexin-Calreticulin cycle.R-HSA-532668-PLCG1 events in ERBB2 signaling.R-HSA-1251932"PTK6 Activates STAT3.R-HSA-8849474;Integration of viral DNA into host genomic DNA< .R-HSA-175567<Membrane binding and targetting of GAG proteins.R-HSA-1744901Oxidative Stress Induced Senescence.R-HSA-25595804NF-kB is activated and signals survival.R-HSA-209560&Interleukin-12 signaling.R-HSA-9020591"Meiotic recombination.R-HSA-912446INOTCH2 Activation and Transmission of Signal to the Nucleus.R-HSA-2979096ANOTCH1 Intracellular Domain Regulates Transcription.R-HSA-21229478Interleukin-4 and Interleukin-13 signaling.R-HSA-6785807'Interleukin-35 Signalling.R-HSA-8984722.NOSTRIN mediated eNOS trafficking.R-HSA-203641&Interleukin-23 signaling.R-HSA-9020933%Interleukin-17 signaling.R-HSA-448424,NOSIP mediated eNOS trafficking.R-HSA-203754$OAS antiviral response.R-HSA-8983711%NOD1-2 Signaling Pathway.R-HSA-168638*NGF-stimulated transcription.R-HSA-90316283Mitochondrial translation termination.R-HSA-5419276,Interleukin-12 family signaling.R-HSA-447115)Oncogene Induced Senescence.R-HSA-2559585&Oncogenic MAPK signaling.R-HSA-6802957%Interleukin-1 processing.R-HSA-448706Meiotic synapsis.R-HSA-1221632+Interleukin-1 family signaling.R-HSA-4466522Organelle biogenesis and maintenance.R-HSA-18522410NIK-->noncanonical NF-kB signaling.R-HSA-5676590!Membrane Trafficking.R-HSA-1999916RNA Polymerase II Transcription Initiation.R-HSA-75953MA tetrasaccharide linker sequence is required for GAG synthesis.R-HSA-1971475+RNA Polymerase II Transcription.R-HSA-73857<Tat-mediated elongation of the HIV-1 transcript.R-HSA-167246MTP53 Regulates Transcription of Caspase Activators and Caspases.R-HSA-6803207>TP53 Regulates Transcription of Cell Cycle Genes.R-HSA-6791312>TP53 Regulates Transcription of Cell Death Genes.R-HSA-5633008>TP53 Regulates Transcription of DNA Repair Genes.R-HSA-6796648TTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.R-HSA-6804116TTP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.R-HSA-6804114~TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.R-HSA-6804115TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.R-HSA-6803205YTRAF6 mediated induction of NFkB and MAP kinases upon TLR7-8 or 9 activation.R-HSA-975138<Tat-mediated HIV elongation arrest and recovery.R-HSA-167243-Telomere Extension By Telomerase.R-HSA-171319<Signaling by high-kinase activity BRAF mutants.R-HSA-68029481Termination of O-glycan biosynthesis.R-HSA-977068"The AIM2 inflammasome.R-HSA-844615"The IPAF inflammasome.R-HSA-844623LThe citric acid (TCA) cycle and respiratory electron transport.R-HSA-1428517GThe role of GTSE1 in G2-M progression after G2 checkpoint.R-HSA-8852276NThrombin signalling through proteinase activated receptors (PARs).R-HSA-4569267Thromboxane signalling through TP receptor.R-HSA-4289302Toll Like Receptor 10 (TLR10) Cascade.R-HSA-1681420Toll Like Receptor 2 (TLR2) Cascade.R-HSA-1814380Toll Like Receptor 3 (TLR3) Cascade.R-HSA-168164,TP53 Regulates Metabolic Genes.R-HSA-56288970TNFR1-mediated ceramide production.R-HSA-56269786TICAM1-dependent activation of IRF3-IRF7.R-HSA-9013973jTFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation.R-HSA-88694961Signaling downstream of RAS mutants.R-HSA-9649948&Sodium-Calcium exchangers.R-HSA-425561JSodium-coupled sulphate, di- and tri-carboxylate transporters.R-HSA-433137.Spry regulation of FGF signaling.R-HSA-1295596 Stabilization of p53.R-HSA-69541*Sulfide oxidation to sulfate.R-HSA-1614517*Sulfur amino acid metabolism.R-HSA-1614635&Suppression of apoptosis.R-HSA-96354652Suppression of phagosomal maturation.R-HSA-9637687ASynthesis And Processing Of GAG, GAGPOL Polyproteins.R-HSA-174495?Synthesis of 12-eicosatetraenoic acid derivatives.R-HSA-2142712?Synthesis of 15-eicosatetraenoic acid derivatives.R-HSA-21427703Synthesis of 5-eicosatetraenoic acids.R-HSA-2142688Synthesis of PC.R-HSA-1483191Synthesis of PG.R-HSA-1483148>Synthesis of PIPs at the early endosome membrane.R-HSA-16605166Synthesis of PIPs at the plasma membrane.R-HSA-1660499Synthesis of PS.R-HSA-1483101DSynthesis of Prostaglandins (PG) and Thromboxanes (TX).R-HSA-2162123GSynthesis of active ubiquitin: roles of E1 and E2 enzymes.R-HSA-8866652<Synthesis of substrates in N-glycan biosythesis.R-HSA-4462190Toll Like Receptor 5 (TLR5) Cascade.R-HSA-1681764Toll Like Receptor 7-8 (TLR7-8) Cascade.R-HSA-1681810Toll Like Receptor 9 (TLR9) Cascade.R-HSA-1681385Uptake and function of diphtheria toxin.R-HSA-5336415(Vesicle-mediated transport.R-HSA-56536561Vif-mediated degradation of APOBEC3G.R-HSA-180585*Viral Messenger RNA Synthesis.R-HSA-168325'Virus Assembly and Release.R-HSA-1682681Vitamin B5 (pantothenate) metabolism.R-HSA-199220-Vitamin C (ascorbate) metabolism.R-HSA-196836aVpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization.R-HSA-180897,Vpu mediated degradation of CD4.R-HSA-180534MWNT ligand secretion is abrogated by the PORCN inhibitor LGK974.R-HSA-53405735WNT5A-dependent internalization of FZD4.R-HSA-5099900>YAP1- and WWTR1 (TAZ)-stimulated gene expression.R-HSA-2032785mRNA Capping.R-HSA-72086+mRNA Editing: C to U Conversion.R-HSA-72200)mRNA Splicing - Minor Pathway.R-HSA-721653mRNA decay by 5' to 3' exoribonuclease.R-HSA-430039'mTORC1-mediated signalling.R-HSA-1662081p75 NTR receptor-mediated signalling.R-HSA-193704%p75NTR signals via NF-kB.R-HSA-1936398rRNA processing in the nucleus and cytosol.R-HSA-8868773rRNA processing.R-HSA-72312,tRNA processing in the nucleus.R-HSA-6784531"VEGFA-VEGFR2 Pathway.R-HSA-44200974Uptake and actions of bacterial toxins.R-HSA-53395621Toll Like Receptor TLR1:TLR2 Cascade.R-HSA-168179,Unfolded Protein Response (UPR).R-HSA-3811191Toll Like Receptor TLR6:TLR2 Cascade.R-HSA-168188(Toll-like Receptor Cascades.R-HSA-1688989Toxicity of botulinum toxin type A (BoNT-A).R-HSA-52509689Toxicity of botulinum toxin type D (BoNT-D).R-HSA-52509559Toxicity of botulinum toxin type E (BoNT-E).R-HSA-52509929Toxicity of botulinum toxin type F (BoNT-F).R-HSA-52509816Transcription from mitochondrial promoters.R-HSA-75944,Transcription of the HIV genome.R-HSA-167172GTranscription-Coupled Nucleotide Excision Repair (TC-NER).R-HSA-67818270Transcriptional Regulation by TP53.R-HSA-37009894Translation initiation complex formation.R-HSA-72649Translation.R-HSA-72766VTransport of bile salts and organic acids, metal ions and amine compounds.R-HSA-425366PTransport of inorganic cations-anions and amino acids-oligopeptides.R-HSA-425393)Transport of small molecules.R-HSA-382551$Triglyceride catabolism.R-HSA-163560%Triglyceride metabolism.R-HSA-8979227!Tryptophan catabolism.R-HSA-71240.Ub-specific processing proteases.R-HSA-56898807Ubiquitin-dependent degradation of Cyclin D.R-HSA-75815(Uncoating of the HIV Virion.R-HSA-162585@Signaling by moderate kinase activity BRAF mutants.R-HSA-68029469Signaling by cytosolic FGFR1 fusion mutants.R-HSA-1839117BRNA Polymerase III Abortive And Retractive Initiation.R-HSA-749476,Repression of WNT target genes.R-HSA-4641265=Regulation of TP53 Activity through Methylation.R-HSA-6804760PRegulation of activated PAK-2p34 by proteasome mediated degradation.R-HSA-211733HRegulation of commissural axon pathfinding by SLIT and ROBO.R-HSA-4285429Regulation of expression of SLITs and ROBOs.R-HSA-9010553qRegulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.R-HSA-210744DRegulation of innate immune responses to cytosolic DNA.R-HSA-3134975-Regulation of mitotic cell cycle.R-HSA-4532763Regulation of the apoptosome activity.R-HSA-96270696Release of Hh-Np from the secreting cell.R-HSA-5362798?Release of apoptotic factors from the mitochondria.R-HSA-111457Reproduction.R-HSA-1474165(Signaling by WNT in cancer.R-HSA-4791275QResolution of AP sites via the single-nucleotide replacement pathway.R-HSA-110381Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat< production by uncoupling proteins.R-HSA-163200+Respiratory electron transport.R-HSA-611105-Response of Mtb to phagocytosis.R-HSA-9637690=Retrograde transport at the Trans-Golgi-Network.R-HSA-6811440=Reversal of alkylation damage by DNA dioxygenases.R-HSA-73943-Reverse Transcription of HIV RNA.R-HSA-162589:Ribosomal scanning and start codon recognition.R-HSA-727026SCF(Skp2)-mediated degradation of p27-p21.R-HSA-1875777SCF-beta-TrCP mediated degradation of Emi1.R-HSA-174113=Regulation of TP53 Activity through Acetylation.R-HSA-68047589Regulation of RUNX2 expression and activity.R-HSA-89399029Regulation of RUNX1 Expression and Activity.R-HSA-8934593'Regulation of RAS by GAPs.R-HSA-5658442/RNA Polymerase III Chain Elongation.R-HSA-73780LRNA Polymerase III Transcription Initiation From Type 1 Promoter.R-HSA-76061LRNA Polymerase III Transcription Initiation From Type 2 Promoter.R-HSA-76066LRNA Polymerase III Transcription Initiation From Type 3 Promoter.R-HSA-760718RNA Polymerase III Transcription Termination.R-HSA-739807RNA polymerase II transcribes snRNA genes.R-HSA-6807505-RUNX3 regulates NOTCH signaling.R-HSA-8941856+Rab regulation of trafficking.R-HSA-9007101cRecognition and association of DNA glycosylase with site containing an affected purine.R-HSA-110330gRecognition and association of DNA glycosylase with site containing an affected pyrimidine.R-HSA-110328!Recycling of eIF2:GDP.R-HSA-72731$Recycling pathway of L1.R-HSA-437239/Reduction of cytosolic Ca++ levels.R-HSA-418359 Regulated Necrosis.R-HSA-5218859KRegulation of APC-C activators between G1-S and early anaphase.R-HSA-176408$Regulation of Apoptosis.R-HSA-169911)Regulation of KIT signaling.R-HSA-14335599Regulation of MECP2 expression and activity.R-HSA-9022692-Regulation of PTEN localization.R-HSA-89487471Regulation of PTEN mRNA translation.R-HSA-89437237Regulation of PTEN stability and activity.R-HSA-89487517SIRT1 negatively regulates rRNA expression.R-HSA-427359PSLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.R-HSA-77588=SLBP independent Processing of Histone Pre-mRNAs.R-HSA-1113672Signaling by FGFR3 fusions in cancer.R-HSA-8853334 Signaling by Hippo.R-HSA-2028269&Signaling by Interleukins.R-HSA-449147!Signaling by Leptin.R-HSA-2586552DSignaling by Ligand-Responsive EGFR Variants in Cancer.R-HSA-5637815Signaling by NOTCH.R-HSA-157118=Signaling by NOTCH1 HD Domain Mutants in Cancer.R-HSA-2691230BSignaling by NOTCH1 HD+PEST Domain Mutants in Cancer.R-HSA-2894858?Signaling by NOTCH1 PEST Domain Mutants in Cancer.R-HSA-2644602+Signaling by NOTCH1 in Cancer.R-HSA-2644603!Signaling by NOTCH1.R-HSA-1980143!Signaling by NOTCH2.R-HSA-1980145!Signaling by NOTCH3.R-HSA-9012852,Signaling by Nuclear Receptors.R-HSA-9006931ASignaling by Overexpressed Wild-Type EGFR in Cancer.R-HSA-5638302Signaling by PDGF.R-HSA-186797&Signaling by RAS mutants.R-HSA-6802949%Signaling by Rho GTPases.R-HSA-194315"Signaling by SCF-KIT.R-HSA-14335573Signaling by TGF-beta Receptor Complex.R-HSA-170834.Signaling by TGFB family members.R-HSA-9006936Signaling by VEGF.R-HSA-194138#Signaling by Hedgehog.R-HSA-5358351(Signaling by FGFR2 IIIa TM.R-HSA-88517081SLC-mediated transmembrane transport.R-HSA-425407+Signaling by FGFR1 in disease.R-HSA-5655302DSMAD2-SMAD3:SMAD4 heterotrimer regulates transcription.R-HSA-2173796ISRP-dependent cotranslational protein targeting to membrane.R-HSA-17993394STAT6-mediated induction of chemokines.R-HSA-3249367?STING mediated induction of host immune responses.R-HSA-18349412SUMO is conjugated to E1 (UBA2:SAE1).R-HSA-3065676/SUMO is proteolytically processed.R-HSA-3065679=SUMO is transferred from E1 to E2 (UBE2I, UBC9).R-HSA-30656785SUMOylation of immune response proteins.R-HSA-47555102SUMOylation of transcription factors.R-HSA-32321186SUMOylation of ubiquitinylation proteins.R-HSA-3232142)Selenoamino acid metabolism.R-HSA-2408522&Selenocysteine synthesis.R-HSA-2408557>Senescence-Associated Secretory Phenotype (SASP).R-HSA-2559582$Sialic acid metabolism.R-HSA-4085001 Signal Transduction.R-HSA-162582!Signal amplification.R-HSA-392518/Signaling by BRAF and RAF fusions.R-HSA-6802952Signaling by EGFR.R-HSA-177929,Signaling by ERBB2 ECD mutants.R-HSA-9665348/Hyaluronan uptake and degradation.R-HSA-2160916)Signaling by Erythropoietin.R-HSA-9006335Hydrolysis of LPC.R-HSA-1483115 Ceramide signalling.R-HSA-193681#Hyaluronan metabolism.R-HSA-2142845Signaling by PTK6.R-HSA-8848021,SHC1 events in ERBB2 signaling.R-HSA-1250196,SHC1 events in ERBB4 signaling.R-HSA-1250347-Scavenging by Class F Receptors.R-HSA-30004840Sema3A PAK dependent Axon repulsion.R-HSA-399954HSema4D mediated inhibition of cell attachment and migration.R-HSA-416550Signaling by BMP.R-HSA-201451 Signaling by ERBB4.R-HSA-12363946Signaling by FGFR2 amplification mutants.R-HSA-2023837(Signaling by FGFR2 fusions.R-HSA-88533338Signaling by Non-Receptor Tyrosine Kinases.R-HSA-90069273Signaling by the B Cell Receptor (BCR).R-HSA-983705)Amino acids regulate mTORC1.R-HSA-9639288#Syndecan interactions.R-HSA-3000170MSynthesis of bile acids and bile salts via 27-hydroxycholesterol.R-HSA-193807TCR signaling.R-HSA-202403OTFAP2 (AP-2) family regulates transcription of cell cycle factors.R-HSA-8866911XTFAP2 (AP-2) family regulates transcription of other transcription factors.R-HSA-8866906WTGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).R-HSA-21737912TNFR1-induced proapoptotic signaling.R-HSA-53577869Toxicity of botulinum toxin type C (BoNT-C).R-HSA-5250971ATranscriptional regulation of pluripotent stem cells.R-HSA-452723uTransport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.R-HSA-159763.Retinoid metabolism and transport.R-HSA-975634RRemoval of aminoterminal propeptides from gamma-carboxylated proteins.R-HSA-159782]Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells.R-HSA-210746GRegulation of actin dynamics for phagocytic cup formation.R-HSA-2029482+PINK1-PRKN Mediated Mitophagy.R-HSA-5205685PPOU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.R-HSA-2892247DPTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.R-HSA-8849471/PTK6 promotes HIF1A stabilization.R-HSA-88575380Phase II - Conjugation of compounds.R-HSA-156580+Plasma lipoprotein remodeling.R-HSA-89638991Platelet Adhesion to exposed collagen.R-HSA-75892 Potassium Channels.R-HSA-1296071<Purine ribonucleoside monophosphate biosynthesis.R-HSA-738171RHO GTPases Activate NADPH Oxidases.R-HSA-5668599YRUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs).R-HSA-8877330FRUNX1 regulates estrogen receptor mediated transcription.R-HSA-8931987IRUNX1 regulates expression of components of tight junctions.R-HSA-8935964NRUNX1 regulates transcription of genes involved in BCR signaling.R-HSA-8939245NRUNX1 regulates transcription of genes involved in WNT signaling.R-HSA-8939256VRUNX1 regulates transcription of genes involved in interleukin signaling.R-HSA-8939247>RUNX2 regulates genes involved in cell migration.R-HSA-8941332@RUNX3 Regulates Immune Response and Cell Migration.R-HSA-8949275:RUNX3 regulates RUNX1-mediated transcription.R-HSA-8951911%RUNX3 regulates p14-ARF.R-HSA-8951936.Recycling of bile acids and salts.R-HSA-159418(Transport of organic anions.R-HSA-8795183Uptake and function of anthrax toxins.R-HSA-5210891'Vasopressin-like receptors.R-HSA-3884798AUF1 (hnRNP D0) binds and destabilizes mRNA.R-HSA-450408AAcrosome Reaction and Sperm:Oocyte Membrane Binding.R-HSA-1300645>Activated NOTCH1 Transmits Signal to the Nucleus.R-HSA-21229483Activated NTRK2 signals through PLCG1.R-HSA-9026527mActivated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.R-HSA-5625886YActivation of APC-C and APC-C:Cdc20 mediated degradation of mitotic proteins.R-HSA-176814AActivation of BAD and translocation to mitochondria .R-HSA-111447,Activation of BH3-only proteins.R-< HSA-114452AActivation of BIM and translocation to mitochondria .R-HSA-111446$Activation of C3 and C5.R-HSA-174577AActivation of NOXA and translocation to mitochondria.R-HSA-1114485Activation of RAC1 downstream of NMDARs.R-HSA-9619229<Activation of gene expression by SREBF (SREBP).R-HSA-2426168rActivation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.R-HSA-72662AActivation, translocation and oligomerization of BAX.R-HSA-114294)Acyl chain remodeling of CL.R-HSA-1482798*Acyl chain remodelling of PC.R-HSA-1482788#Adenosine P1 receptors.R-HSA-417973@Adrenaline,noradrenaline inhibits insulin secretion.R-HSA-400042AAdvanced glycosylation endproduct receptor signaling.R-HSA-879415Aggrephagy.R-HSA-9646399$Amine Oxidase reactions.R-HSA-140179JAbortive elongation of HIV-1 transcript in the absence of Tat.R-HSA-1672428ATF6 (ATF6-alpha) activates chaperone genes.R-HSA-381183&Visual phototransduction.R-HSA-2187338NATF4 activates genes in response to endoplasmic reticulum stress.R-HSA-3809943WNT ligand biogenesis and trafficking.R-HSA-3238698+WNT mediated activation of DVL.R-HSA-2016883WNT5:FZD7-mediated leishmania damping.R-HSA-96733249ZBP1(DAI) mediated induction of type I IFNs.R-HSA-1606322+mRNA Editing: A to I Conversion.R-HSA-75064#2-LTR circle formation.R-HSA-164843'ABC transporter disorders.R-HSA-56190843ABC transporters in lipid homeostasis.R-HSA-13690623ABC-family proteins mediated transport.R-HSA-3825567ADP signalling through P2Y purinoceptor 12.R-HSA-392170:ALKBH2 mediated reversal of alkylation damage.R-HSA-112122:ALKBH3 mediated reversal of alkylation damage.R-HSA-112126>APC-C-mediated degradation of cell cycle proteins.R-HSA-1741439APC-C:Cdc20 mediated degradation of Cyclin B.R-HSA-1740488APC-C:Cdc20 mediated degradation of Securin.R-HSA-174154AAPC-C:Cdc20 mediated degradation of mitotic proteins.R-HSA-176409uAPC-C:Cdh1 mediated degradation of Cdc20 and other APC-C:Cdh1 targeted proteins in late mitosis-early G1.R-HSA-1741784APC-Cdc20 mediated degradation of Nek2A.R-HSA-179409tAPC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint.R-HSA-179419dAPEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway.R-HSA-5649702<APOBEC3G mediated resistance to HIV-1 infection.R-HSA-180689,PI3K events in ERBB4 signaling.R-HSA-1250342,PI3K events in ERBB2 signaling.R-HSA-1963642(Other interleukin signaling.R-HSA-449836"Collagen degradation.R-HSA-14424905Degradation of the extracellular matrix.R-HSA-1474228%Downstream TCR signaling.R-HSA-202424BDownstream signaling events of B Cell Receptor (BCR).R-HSA-1168372-EGFR Transactivation by Gastrin.R-HSA-2179392,ERBB2 Activates PTK6 Signaling.R-HSA-8847993+ERBB2 Regulates Cell Motility.R-HSA-6785631DErythrocytes take up carbon dioxide and release oxygen.R-HSA-1237044DErythrocytes take up oxygen and release carbon dioxide.R-HSA-1247673-FCERI mediated NF-kB activation.R-HSA-2871837<FGFR1c and Klotho ligand binding and activation.R-HSA-190374!FasL- CD95L signaling.R-HSA-75157Fatty acids.R-HSA-2119353Fc epsilon receptor (FCERI) signaling.R-HSA-2454202<Fcgamma receptor (FCGR) dependent phagocytosis.R-HSA-2029480\Ficolins bind to repetitive carbohydrate structures on the target cell surface.R-HSA-28550864Formation of editosomes by ADAR proteins.R-HSA-77042.G alpha (12-13) signalling events.R-HSA-416482*G alpha (i) signalling events.R-HSA-4185940G protein gated Potassium channels.R-HSA-1296059'GABA B receptor activation.R-HSA-977444%GABA receptor activation.R-HSA-977443JCross-presentation of soluble exogenous antigens (endosomes).R-HSA-1236978Circadian Clock.R-HSA-400253,GRB2 events in ERBB2 signaling.R-HSA-1963640$Chylomicron remodeling.R-HSA-89639010AKT-mediated inactivation of FOXO1A.R-HSA-211163;ARL13B-mediated ciliary trafficking of INPP5E.R-HSA-56249581Activated NTRK3 signals through RAS.R-HSA-9034864>Activation of G protein gated Potassium channels.R-HSA-1296041*Activation of GABAB receptors.R-HSA-9913650Activation of NF-kappaB in B cells.R-HSA-1169091Activation of SMO.R-HSA-5635838CActivation of the AP-1 family of transcription factors.R-HSA-450341LActivation of the TFAP2 (AP-2) family of transcription factors.R-HSA-88669072Acyl chain remodeling of DAG and TAG.R-HSA-14828831Adenylate cyclase activating pathway.R-HSA-170660FAdrenaline signalling through Alpha-2 adrenergic receptor.R-HSA-392023>Assembly of active LPL and LIPC lipase complexes.R-HSA-8963889CBMAL1:CLOCK,NPAS2 activates circadian gene expression.R-HSA-1368108/Bile acid and bile salt metabolism.R-HSA-194068'C6 deamination of adenosine.R-HSA-75102*CD22 mediated BCR regulation.R-HSA-5690714CHL1 interactions.R-HSA-447041)CLEC7A (Dectin-1) signaling.R-HSA-5607764+Cargo concentration in the ER.R-HSA-5694530"Chylomicron assembly.R-HSA-8963888'GPCR downstream signalling.R-HSA-388396,GRB7 events in ERBB2 signaling.R-HSA-1306955(Olfactory Signaling Pathway.R-HSA-381753Lysine catabolism.R-HSA-71064=MECP2 regulates neuronal receptors and channels.R-HSA-9022699?MECP2 regulates transcription of neuronal ligands.R-HSA-9022702/MGMT-mediated DNA damage reversal.R-HSA-56576550Metabolism of fat-soluble vitamins.R-HSA-68066671Metabolism of vitamins and cofactors.R-HSA-196854Methylation.R-HSA-1565814Mitochondrial transcription termination.R-HSA-163316Mitophagy.R-HSA-52056476Molecules associated with elastic fibres.R-HSA-2129379Myogenesis.R-HSA-5257938NR1D1 (REV-ERBA) represses gene expression.R-HSA-1368071ONR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis .R-HSA-9632974XNegative regulation of TCF-dependent signaling by DVL-interacting proteins.R-HSA-5368598VNegative regulation of TCF-dependent signaling by WNT ligand antagonists.R-HSA-3772470%Neurofascin interactions.R-HSA-4470439Neurophilin interactions with VEGF and VEGFR.R-HSA-1943064Non-integrin membrane-ECM interactions.R-HSA-30001713Nuclear Receptor transcription pathway.R-HSA-383280(Nuclear signaling by ERBB4.R-HSA-1251985%Nucleobase biosynthesis.R-HSA-8956320-O2-CO2 exchange in erythrocytes.R-HSA-1480926$MAPK3 (ERK1) activation.R-HSA-110056+Linoleic acid (LA) metabolism.R-HSA-2046105QGamma carboxylation, hypusine formation and arylsulfatase activation.R-HSA-163841*Ligand-receptor interactions.R-HSA-56326816Gamma-carboxylation of protein precursors.R-HSA-159740TGamma-carboxylation, transport, and amino-terminal cleavage of proteins.R-HSA-159854=Gastrin-CREB signalling pathway via PKC and MAPK.R-HSA-8819075Generation of second messenger molecules.R-HSA-202433 Glycogen synthesis.R-HSA-3322077!HS-GAG biosynthesis.R-HSA-2022928 HS-GAG degradation.R-HSA-20240969Heparan sulfate-heparin (HS-GAG) metabolism.R-HSA-1638091IRS activation.R-HSA-74713PInhibition of voltage gated Ca2+ channels via Gbeta-gamma subunits.R-HSA-997272YInsertion of tail-anchored proteins into the endoplasmic reticulum membrane.R-HSA-9609523/Integrin cell surface interactions.R-HSA-216083%Interleukin-2 signaling.R-HSA-9020558&Interleukin-33 signaling.R-HSA-9014843,Intracellular oxygen transport.R-HSA-89816077Intrinsic Pathway of Fibrin Clot Formation.R-HSA-140837-Inwardly rectifying K+ channels.R-HSA-1296065aJNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.R-HSA-450321 Killing mechanisms.R-HSA-9664420VLRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.R-HSA-31349734Lectin pathway of complement activation.R-HSA-166662<Amino acid transport across the plasma membrane.R-HSA-352230$Amyloid fiber formation.R-HSA-9772253HuR (ELAVL1) binds and stabilizes mRNA.R-HSA-450520,Erythropoietin activates STAT5.R-HSA-9027283LERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression.R-HSA-427389$ESR-mediated signaling.R-HSA-8939211*Early Phase of HIV Life Cycle.R-HSA-1625940Eicosanoid ligand-binding receptors.R-HSA-391903/Elevation of cytosolic Ca2+ levels.R-HSA-139853EEndosomal Sorting Complex< Required For Transport (ESCRT).R-HSA-917729EEntry of Influenza Virion into Host Cell via Endocytosis.R-HSA-168275Ephrin signaling.R-HSA-3928664GErythropoietin activates Phosphoinositide-3-kinase (PI3K).R-HSA-9027276CErythropoietin activates Phospholipase C gamma (PLCG).R-HSA-90272770Estrogen-dependent gene expression.R-HSA-9018519@Anchoring of the basal body to the plasma membrane.R-HSA-5620912.Eukaryotic Translation Elongation.R-HSA-156842-Eukaryotic Translation Initiation.R-HSA-72613.Eukaryotic Translation Termination.R-HSA-72764RFBXL7 down-regulates AURKA during mitotic entry and in early mitosis.R-HSA-8854050FCGR activation.R-HSA-2029481,FCGR3A-mediated IL10 synthesis.R-HSA-9664323.FGFR1 mutant receptor activation.R-HSA-1839124(FGFR2 alternative splicing.R-HSA-6803529FLT3 Signaling.R-HSA-9607240RFactors involved in megakaryocyte development and platelet production.R-HSA-983231"ER-Phagosome pathway.R-HSA-12369742ER Quality Control Compartment (ERQC).R-HSA-901032-EPHB-mediated forward signaling.R-HSA-39286624EPH-ephrin mediated repulsion of cells.R-HSA-3928665MDeposition of new CENPA-containing nucleosomes at the centromere.R-HSA-606279Depurination.R-HSA-73927Depyrimidination.R-HSA-73928iDeregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.R-HSA-88628037Detoxification of Reactive Oxygen Species.R-HSA-3299685Deubiquitination.R-HSA-5688426Disease.R-HSA-1643685^Diseases of signal transduction by growth factor receptors and second messengers.R-HSA-56632025Disorders of transmembrane transporters.R-HSA-5619115&Dissolution of Fibrin Clot.R-HSA-75205/Downregulation of ERBB2 signaling.R-HSA-88637955Downregulation of ERBB2:ERBB3 signaling.R-HSA-1358803/Downregulation of ERBB4 signaling.R-HSA-1253288FDownregulation of SMAD2-3:SMAD4 transcriptional activity.R-HSA-2173795;Downregulation of TGF-beta receptor signaling.R-HSA-2173788+Downstream signal transduction.R-HSA-186763%Dual incision in TC-NER.R-HSA-6782135HE2F-enabled inhibition of pre-replication complex formation.R-HSA-113507 EGFR downregulation.R-HSA-1829716EGFR interacts with phospholipase C-gamma.R-HSA-212718"EPH-Ephrin signaling.R-HSA-2682334#Fatty acid metabolism.R-HSA-8978868'Fatty acyl-CoA biosynthesis.R-HSA-75105)Folding of actin by CCT-TriC.R-HSA-390450+G2-M DNA replication checkpoint.R-HSA-69478%Gap junction degradation.R-HSA-190873EGap-filling DNA repair synthesis and ligation in TC-NER.R-HSA-6782210`Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation.R-HSA-8950505+Gene expression (Transcription).R-HSA-74160*Generic Transcription Pathway.R-HSA-212436?Global Genome Nucleotide Excision Repair (GG-NER).R-HSA-5696399+Glucagon-type ligand receptors.R-HSA-420092Gluconeogenesis.R-HSA-70263Glucose metabolism.R-HSA-70326/Glycogen breakdown (glycogenolysis).R-HSA-70221Glycolysis.R-HSA-70171@Golgi Cisternae Pericentriolar Stack Reorganization.R-HSA-162658.Golgi-to-ER retrograde transport.R-HSA-8856688.Growth hormone receptor signaling.R-HSA-982772HIV Infection.R-HSA-162906HIV Life Cycle.R-HSA-162587)HIV Transcription Elongation.R-HSA-167169)HIV Transcription Initiation.R-HSA-167161/HIV elongation arrest and recovery.R-HSA-167287GHSP90 chaperone cycle for steroid hormone receptors (SHR).R-HSA-3371497Hemostasis.R-HSA-109582CGTP hydrolysis and joining of the 60S ribosomal subunit.R-HSA-72706&G2-M DNA damage checkpoint.R-HSA-69473JFormation of HIV elongation complex in the absence of HIV Tat.R-HSA-167152'G1-S DNA Damage Checkpoints.R-HSA-69615GFormation of HIV-1 elongation complex containing HIV-1 Tat.R-HSA-1672005Formation of Incision Complex in GG-NER.R-HSA-56963958Formation of RNA Pol II elongation complex .R-HSA-112382LFormation of Senescence-Associated Heterochromatin Foci (SAHF).R-HSA-25595846Formation of TC-NER Pre-Incision Complex.R-HSA-67818234Formation of a pool of free 40S subunits.R-HSA-72689/Formation of annular gap junctions.R-HSA-196025$Formation of apoptosome.R-HSA-1114585Formation of selenosugars for excretion.R-HSA-24084996Formation of the Early Elongation Complex.R-HSA-113418&Formation of the Editosome.R-HSA-75094<Formation of the HIV-1 Early Elongation Complex.R-HSA-167158FFormation of the beta-catenin:TCF transactivating complex.R-HSA-201722OFormation of the ternary complex, and subsequently, the 43S complex.R-HSA-72695CFormation of tubulin folding intermediates by CCT-TriC.R-HSA-389960*G alpha (z) signalling events.R-HSA-4185971G beta:gamma signalling through BTK.R-HSA-89643156G beta:gamma signalling through PI3Kgamma.R-HSA-3924515G beta:gamma signalling through PLC beta.R-HSA-418217,G-protein beta:gamma signalling.R-HSA-397795&G-protein mediated events.R-HSA-1120406Degradation of cysteine and homocysteine.R-HSA-1614558!Degradation of AXIN.R-HSA-46412573Defective CFTR causes cystic fibrosis.R-HSA-5678895BBiosynthesis of aspirin-triggered D-series resolvins.R-HSA-9020265GBiosynthesis of specialized proresolving mediators (SPMs).R-HSA-9018678,Biotin transport and metabolism.R-HSA-1967800Branched-chain amino acid catabolism.R-HSA-70895,Breakdown of the nuclear lamina.R-HSA-3522381Budding and maturation of HIV virion.R-HSA-1625884Butyrophilin (BTN) family interactions.R-HSA-8851680.CD28 dependent PI3K-Akt signaling.R-HSA-3893577CLEC7A (Dectin-1) induces NFAT activation.R-HSA-5607763;COPI-dependent Golgi-to-ER retrograde traffic.R-HSA-6811434-COPII-mediated vesicle transport.R-HSA-204005NCREB1 phosphorylation through the activation of Adenylate Cyclase.R-HSA-442720YCREB1 phosphorylation through the activation of CaMKII-CaMKK-CaMKIV cascasde.R-HSA-442729 Ca-dependent events.R-HSA-111996Ca2+ pathway.R-HSA-4086398CaM pathway.R-HSA-1119975CaMK IV-mediated phosphorylation of CREB.R-HSA-111932(Calcineurin activates NFAT.R-HSA-2025928&Calmodulin induced events.R-HSA-111933(Calnexin-calreticulin cycle.R-HSA-9010420Cap-dependent Translation Initiation.R-HSA-72737ACargo recognition for clathrin-mediated endocytosis.R-HSA-8856825fBiosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR).R-HSA-9026766.Biosynthesis of EPA-derived SPMs.R-HSA-9018679QCaspase activation via Dependence Receptors in the absence of ligand.R-HSA-4188896Biosynthesis of E-series 18(S)-resolvins.R-HSA-9018896WAntigen Presentation: Folding, assembly and peptide loading of class I MHC.R-HSA-9831703Antigen processing-Cross presentation.R-HSA-1236975HAntigen processing: Ubiquitination & Proteasome degradation.R-HSA-9831680Apoptosis induced DNA fragmentation.R-HSA-140342Apoptosis.R-HSA-109581/Apoptotic factor-mediated response.R-HSA-111471)Arachidonic acid metabolism.R-HSA-2142753'Assembly Of The HIV Virion.R-HSA-175474=Assembly of Viral Components at the Budding Site.R-HSA-168316MAssociation of TriC-CCT with target proteins during biosynthesis.R-HSA-390471-Attachment of GPI anchor to uPAR.R-HSA-1627912Autodegradation of Cdh1 by Cdh1:APC-C.R-HSA-1740849Autointegration results in viral DNA circles.R-HSA-177539Axon guidance.R-HSA-422475&Axonal growth stimulation.R-HSA-209563YBH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.R-HSA-1114533Base-Excision Repair, AP Site Formation.R-HSA-739290Biosynthesis of D-series resolvins.R-HSA-9018676.Biosynthesis of DHA-derived SPMs.R-HSA-9018677<Biosynthesis of DHA-derived sulfido conjugates.R-HSA-90263956Biosynthesis of E-series 18(R)-resolvins.R-HSA-9023661!Carnitine metabolism.R-HSA-200425?Caspase-mediated cleavage of cytoskeletal proteins.R-HSA-264870<Dectin-1 mediated noncanonical NF-kB signaling.R-HSA-5607761BConstitutive Signaling by NOTCH1 PEST Domain Mutants.R-HSA-2644606PCooperation of PDCL (PhLP1) and TRiC-CCT in G-protein beta folding.R-HSA-6814122PCooperation of Prefoldin and TriC-CCT in actin and tubulin folding.R-HSA-389958-Costimulation by the CD28 family.R-HSA-388841CCyclin A-B1-B2 associated events during G2-M transition.R-HSA-69273<Cyclin A:Cdk2-associated even< ts at S phase entry.R-HSA-69656>Cyclin E associated events during G1-S transition .R-HSA-692025Cytochrome c-mediated apoptotic response.R-HSA-1114611Cytokine Signaling in Immune system.R-HSA-12802154Cytosolic iron-sulfur cluster assembly.R-HSA-2564830;Cytosolic sensors of pathogen-associated DNA .R-HSA-1834949#DAG and IP3 signaling.R-HSA-1489509 DAP12 interactions.R-HSA-2172127DDDX58-IFIH1-mediated induction of interferon-alpha-beta.R-HSA-168928\DEx-H-box helicases activate type I IFN and inflammatory cytokines production .R-HSA-3134963.DNA Damage Recognition in GG-NER.R-HSA-5696394DNA Damage Reversal.R-HSA-73942;DNA Damage-Telomere Stress Induced Senescence.R-HSA-2559586DSCAM interactions.R-HSA-376172FDeactivation of the beta-catenin transactivating complex.R-HSA-3769402"Deadenylation of mRNA.R-HSA-429947/Deadenylation-dependent mRNA decay.R-HSA-429914GConversion from APC-C:Cdc20 to APC-C:Cdh1 in late anaphase.R-HSA-176407EConstitutive Signaling by NOTCH1 HD+PEST Domain Mutants.R-HSA-2894862ACdc20:Phospho-APC-C mediated degradation of Cyclin A.R-HSA-174184@Constitutive Signaling by NOTCH1 HD Domain Mutants.R-HSA-2691232"Cell Cycle Checkpoints.R-HSA-69620Cell Cycle, Mitotic.R-HSA-69278;Cell death signalling via NRAGE, NRIF and NADE.R-HSA-204998:Cell recruitment (pro-inflammatory response).R-HSA-9664424!Cellular Senescence.R-HSA-25595834Cellular responses to external stimuli.R-HSA-8953897*Cellular responses to stress.R-HSA-22627527ChREBP activates metabolic gene expression.R-HSA-163765*Chaperone Mediated Autophagy.R-HSA-96138290Chaperonin-mediated protein folding.R-HSA-390466JChk1-Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.R-HSA-75035Cilium Assembly.R-HSA-56178332Class B-2 (Secretin family receptors).R-HSA-373080CClass I MHC mediated antigen processing & presentation.R-HSA-9831699Class I peroxisomal membrane protein import.R-HSA-9603798+Cleavage of the damaged purine.R-HSA-1103310Cleavage of the damaged pyrimidine .R-HSA-110329$Coenzyme A biosynthesis.R-HSA-196783JCompeting endogenous RNAs (ceRNAs) regulate PTEN translation.R-HSA-8948700"Complex I biogenesis.R-HSA-6799198NConstitutive Signaling by Ligand-Responsive EGFR Cancer Variants.R-HSA-1236382tRNA processing.R-HSA-72306Muscle contraction.R-HSA-397014"PLC-gamma1 signalling.R-HSA-1670218Negative regulation of the PI3K-AKT network.R-HSA-199418NrCAM interactions.R-HSA-447038HNuclear Events (kinase and transcription factor activation).R-HSA-198725*Other semaphorin interactions.R-HSA-416700!PI-3K cascade:FGFR1.R-HSA-5654689!PI-3K cascade:FGFR3.R-HSA-5654710*PI3K-AKT Signaling in Cancer.R-HSA-2219528=PI5P, PP2A and IER3 Regulate PI3K-AKT Signaling.R-HSA-6811558,Phase 3 - rapid repolarisation.R-HSA-55768900FGFR2 ligand binding and activation.R-HSA-1902415Phospholipase C-mediated cascade: FGFR1.R-HSA-56542195Phospholipase C-mediated cascade; FGFR3.R-HSA-5654227$Plasmalogen biosynthesis.R-HSA-75896(RHO GTPases Activate ROCKs.R-HSA-56271170trans-Golgi Network Vesicle Budding.R-HSA-1999924p53-Dependent G1-S DNA damage checkpoint.R-HSA-695800p53-Dependent G1 DNA Damage Response.R-HSA-69563.XBP1(S) activates chaperone genes.R-HSA-3810384Negative regulation of FGFR2 signaling.R-HSA-5654727WNef mediated downregulation of MHC class I complex cell surface expression.R-HSA-164940-Nef Mediated CD4 Down-regulation.R-HSA-167590"NTRK2 activates RAC1.R-HSA-90327591FGFR2c ligand binding and activation.R-HSA-1903750FGFR3 ligand binding and activation.R-HSA-190239.FGFR3 mutant receptor activation.R-HSA-20335141FGFR3c ligand binding and activation.R-HSA-190372=FOXO-mediated transcription of cell cycle genes.R-HSA-9617828*FRS-mediated FGFR1 signaling.R-HSA-5654693JFatty Acids bound to GPR40 (FFAR1) regulate insulin secretion.R-HSA-4343168Free fatty acids regulate insulin secretion.R-HSA-4004516ADP signalling through P2Y purinoceptor 1.R-HSA-4185920Golgi Associated Vesicle Biogenesis.R-HSA-432722+IRE1alpha activates chaperones.R-HSA-381070PIntracellular metabolism of fatty acids regulates insulin secretion.R-HSA-434313"Laminin interactions.R-HSA-3000157GMetabolism of nitric oxide: NOS3 activation and regulation.R-HSA-202131%Miscellaneous substrates.R-HSA-211958TBC-RABGAPs.R-HSA-8854214INOTCH4 Activation and Transmission of Signal to the Nucleus.R-HSA-9013700Wax biosynthesis.R-HSA-9640463.Wax and plasmalogen biosynthesis.R-HSA-88485842ROS and RNS production in phagocytes.R-HSA-1222556(SHC-mediated cascade:FGFR1.R-HSA-5654688TRAIL signaling.R-HSA-75158"Signaling by Activin.R-HSA-1502540Signaling by FGFR.R-HSA-190236 Signaling by FGFR1.R-HSA-5654736+Signaling by FGFR3 in disease.R-HSA-56553328Signaling by FGFR3 point mutants in cancer.R-HSA-8853338 Signaling by FGFR3.R-HSA-5654741TTP53 Regulates Transcription of Genes Involved in Cytochrome C Release.R-HSA-6803204ITP53 Regulates Transcription of Death Receptors and Ligands.R-HSA-6803211 Signaling by NODAL.R-HSA-1181150QSignaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.R-HSA-2660825'Signaling by NTRK2 (TRKB).R-HSA-90061154Signaling by Receptor Tyrosine Kinases.R-HSA-9006934;Signaling by activated point mutants of FGFR1.R-HSA-1839122;Signaling by activated point mutants of FGFR3.R-HSA-1839130&Smooth Muscle Contraction.R-HSA-445355.TET1,2,3 and TDG demethylate DNA.R-HSA-52210305Serotonin Neurotransmitter Release Cycle.R-HSA-181429#TRKA activation by NGF.R-HSA-1870422RUNX3 regulates CDKN1A transcription.R-HSA-8941855-Rhesus blood group biosynthesis.R-HSA-9037628DWNT5A-dependent internalization of FZD2, FZD5 and ROR2.R-HSA-51407459RUNX3 regulates YAP1-mediated transcription.R-HSA-8951671)Receptor Mediated Mitophagy.R-HSA-8934903'Reelin signalling pathway.R-HSA-88663761Regulation of FZD by ubiquitination.R-HSA-4641263dTransport of nucleosides and free purine and pyrimidine bases across the plasma membrane.R-HSA-83936HTranscriptional activity of SMAD2-SMAD3:SMAD4 heterotrimer.R-HSA-2173793ARegulation of TP53 Activity through Phosphorylation.R-HSA-6804756)Regulation of TP53 Activity.R-HSA-5633007,Regulation of TP53 Degradation.R-HSA-6804757;Regulation of TP53 Expression and Degradation.R-HSA-6806003@Transcriptional activation of p53 responsive genes .R-HSA-69560ETranscriptional activation of cell cycle inhibitor p21 .R-HSA-69895,Regulation of insulin secretion.R-HSA-422356.Toxicity of tetanus toxin (TeNT).R-HSA-5250982Tie2 Signaling.R-HSA-210993;The retinoid cycle in cones (daylight vision).R-HSA-2187335.FGFR2 mutant receptor activation.R-HSA-18391268Synthesis of very long-chain fatty acyl-CoAs.R-HSA-758761FGFR1c ligand binding and activation.R-HSA-190373.Blood group systems biosynthesis.R-HSA-9033658)Activation of TRKA receptors.R-HSA-1870150EPHA-mediated growth cone collapse.R-HSA-3928663Alpha-defensins.R-HSA-14620542Antagonism of Activin by Follistatin.R-HSA-2473224JAssembly of collagen fibrils and other multimeric structures.R-HSA-2022090ECM proteoglycans.R-HSA-30001783BDNF activates NTRK2 (TRKB) signaling.R-HSA-90249095Downstream signaling of activated FGFR1.R-HSA-56546874Beta-catenin independent WNT signaling.R-HSA-3858494"Biological oxidations.R-HSA-2118594Dopamine Neurotransmitter Release Cycle.R-HSA-212676ERK-MAPK targets.R-HSA-198753;CD163 mediating an anti-inflammatory response.R-HSA-96628341COPI-mediated anterograde transport.R-HSA-6807878'CTLA4 inhibitory signaling.R-HSA-3895133Cell-extracellular matrix interactions.R-HSA-446353&Cellular hexose transport.R-HSA-189200OCross-presentation of particulate exogenous antigens (phagosomes).R-HSA-1236973Cristae formation.R-HSA-8949613^Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant.R-HSA-26608261FGFR1b ligand binding and activation.R-HSA-190370;Constitutive Signaling by AKT1 E17K in Cancer.R-HSA-5674400*Activation of RAS in B cells.R-HSA-1169092*Collagen chain trimerization.R-HSA-8948216TEstrogen-dependent nuclear events downstream of ESR-membrane signaling.R-HS< A-9634638%ARMS-mediated activation.R-HSA-170984EAMPK inhibits chREBP transcriptional activation activity.R-HSA-163680.Activated point mutants of FGFR2.R-HSA-2033519XAbasic sugar-phosphate removal via the single-nucleotide replacement pathway.R-HSA-73930.Extra-nuclear estrogen signaling.R-HSA-90093910FGFR1 ligand binding and activation.R-HSA-190242=Energy dependent regulation of mTOR by LKB1-AMPK.R-HSA-3809726Acetylcholine regulates insulin secretion.R-HSA-399997,GP1b-IX-V activation signalling.R-HSA-430116`NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose.R-HSA-9031528ANOTCH2 intracellular domain regulates transcription.R-HSA-2197563,MyD88-independent TLR4 cascade .R-HSA-166166UNR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis.R-HSA-9623433*FRS-mediated FGFR3 signaling.R-HSA-5654706>GABA synthesis, release, reuptake and degradation.R-HSA-8885902Nectin-Necl trans heterodimerization.R-HSA-420597 GPCR ligand binding.R-HSA-500792:Norepinephrine Neurotransmitter Release Cycle.R-HSA-181430GGRB2:SOS provides linkage to MAPK signaling for Integrins .R-HSA-3541940Mtb iron assimilation by chelation.R-HSA-1222449*FRS-mediated FGFR2 signaling.R-HSA-5654700'Metal ion SLC transporters.R-HSA-425410-Nef Mediated CD8 Down-regulation.R-HSA-182218HNef mediated downregulation of CD28 cell surface expression.R-HSA-164939.Netrin mediated repulsion signals.R-HSA-418886*Fibronectin matrix formation.R-HSA-1566977'Neurotransmitter clearance.R-HSA-1123118Formation of Fibrin Clot (Clotting Cascade).R-HSA-140877Fertilization.R-HSA-11870001Formation of the cornified envelope.R-HSA-6809371Neuronal System.R-HSA-112316+Neurotransmitter release cycle.R-HSA-112310&Free fatty acid receptors.R-HSA-444209#Nicotinamide salvaging.R-HSA-197264kNef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters.R-HSA-164938%Frs2-mediated activation.R-HSA-1709685Glutamate Neurotransmitter Release Cycle.R-HSA-2105001Negative regulation of MAPK pathway.R-HSA-5675221*G alpha (q) signalling events.R-HSA-4164764Negative regulation of FGFR4 signaling.R-HSA-5654733"Nicotinate metabolism.R-HSA-196807*FRS-mediated FGFR4 signaling.R-HSA-5654712LNeurotransmitter receptors and postsynaptic signal transmission.R-HSA-112314TGlutamate binding, activation of AMPA receptors and synaptic plasticity.R-HSA-399721'Metabolism of carbohydrates.R-HSA-71387/Interleukin receptor SHC signaling.R-HSA-912526/Insulin receptor signalling cascade.R-HSA-74751-Integration of energy metabolism.R-HSA-163685HSF1 activation.R-HSA-3371511Integrin signaling.R-HSA-354192CInteraction With Cumulus Cells And The Zona Pellucida.R-HSA-2534343'Interferon gamma signaling.R-HSA-877300%Interleukin-1 signaling.R-HSA-9020702&Interleukin-10 signaling.R-HSA-6783783+Interleukin-2 family signaling.R-HSA-451927-Interleukin-20 family signaling.R-HSA-8854691&Interleukin-21 signaling.R-HSA-9020958Insulin processing.R-HSA-264876-Initial triggering of complement.R-HSA-166663;Metabolism of Angiotensinogen to Angiotensins.R-HSA-2022377SIRAK2 mediated activation of TAK1 complex upon TLR7-8 or 9 stimulation.R-HSA-975163GHighly calcium permeable nicotinic acetylcholine receptors.R-HSA-629597YHh mutants that don't undergo autocatalytic processing are degraded by ERAD.R-HSA-53627682Hh mutants abrogate ligand secretion.R-HSA-5387390THighly calcium permeable postsynaptic nicotinic acetylcholine receptors.R-HSA-629594SHighly sodium permeable postsynaptic acetylcholine nicotinic receptors.R-HSA-629587%IGF1R signaling cascade.R-HSA-24289246IRAK2 mediated activation of TAK1 complex.R-HSA-937042$IRS-mediated signalling.R-HSA-1123993IRS-related events triggered by IGF1R.R-HSA-2428928'ISG15 antiviral mechanism.R-HSA-1169408UImmunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.R-HSA-198933(Hedgehog ligand biogenesis.R-HSA-5358346,HSF1-dependent transactivation.R-HSA-3371571&Interleukin-27 signaling.R-HSA-9020956>Interleukin-3, Interleukin-5 and GM-CSF signaling.R-HSA-512988&Interleukin-38 signaling.R-HSA-9007892*Glycosphingolipid metabolism.R-HSA-1660662LLocalization of the PINCH-ILK-PARVIN complex to focal adhesions.R-HSA-446343(Lysosome Vesicle Biogenesis.R-HSA-432720AMAPK targets- Nuclear events mediated by MAP kinases.R-HSA-450282*Glycosaminoglycan metabolism.R-HSA-1630316$MAPK1 (ERK2) activation.R-HSA-112411"Glycoprotein hormones.R-HSA-209822,Interleukin-6 family signaling.R-HSA-6783589!Glycogen metabolism.R-HSA-8982491OMECP2 regulates transcription of genes involved in GABA signaling.R-HSA-9022927,Glycerophospholipid catabolism.R-HSA-6814848,MTF1 activates gene expression.R-HSA-5660489Macroautophagy.R-HSA-1632852"Melanin biosynthesis.R-HSA-5662702HCN channels.R-HSA-1296061Lactose synthesis.R-HSA-5653890%Interleukin-6 signaling.R-HSA-1059683%Interleukin-9 signaling.R-HSA-8985947!Intra-Golgi traffic.R-HSA-6811438#Invadopodia formation.R-HSA-8941237'HDMs demethylate histones.R-HSA-3214842HDL remodeling.R-HSA-8964058:Ion influx-efflux at host-pathogen interface.R-HSA-6803544HDL clearance.R-HSA-89640115Ionotropic activity of kainate receptors.R-HSA-451306HDL assembly.R-HSA-8963896Keratinization.R-HSA-6805567-O-linked glycosylation of mucins.R-HSA-913709Signalling to ERKs.R-HSA-187687+Signaling by PDGFR in disease.R-HSA-9671555>Signaling by PDGFRA extracellular domain mutants.R-HSA-9673770XSignaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants.R-HSA-9673767OSignaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R).R-HSA-2404192Signaling by WNT.R-HSA-195721Signalling to ERK5.R-HSA-198765 Signalling to STAT3.R-HSA-198745Signaling by NTRKs.R-HSA-166520.Signalling to p38 via RIT and RIN.R-HSA-187706&Sperm Motility And Taxes.R-HSA-1300642(Striated Muscle Contraction.R-HSA-390522#Surfactant metabolism.R-HSA-5683826<Synthesis of Leukotrienes (LT) and Eoxins (EX).R-HSA-21426915Synthesis of PIPs at the Golgi membrane.R-HSA-1660514&Signaling by NTRK1 (TRKA).R-HSA-187037 Serotonin receptors.R-HSA-390666-Scavenging by Class A Receptors.R-HSA-3000480-Scavenging by Class B Receptors.R-HSA-3000471-Scavenging by Class H Receptors.R-HSA-3000497+Sema4D in semaphorin signaling.R-HSA-400685CSema4D induced cell migration and growth-cone collapse.R-HSA-416572&Signal transduction by L1.R-HSA-445144)Signaling by Insulin receptor.R-HSA-74752*Signaling by FGFR in disease.R-HSA-1226099+Signaling by FGFR2 in disease.R-HSA-5655253 Signaling by FGFR2.R-HSA-5654738 Signaling by FGFR4.R-HSA-5654743Signaling by GPCR.R-HSA-372790VSynthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).R-HSA-381771RTAK1 activates NFkB by phosphorylation and activation of IKKs complex.R-HSA-445989,VxPx cargo-targeting to cilium.R-HSA-5620916FTransport of vitamins, nucleosides, and related molecules.R-HSA-425397?Transport to the Golgi and subsequent modification.R-HSA-948021*Type I hemidesmosome assembly.R-HSA-4461073VLDLR internalisation and degradation.R-HSA-88664277TCF dependent signaling in response to WNT.R-HSA-201681cGMP effects.R-HSA-418457<p130Cas linkage to MAPK signaling for integrins.R-HSA-3727082rRNA processing in the mitochondrion.R-HSA-8868766%Transport of fatty acids.R-HSA-8049142Transmission across Chemical Synapses.R-HSA-1123151Transcriptional regulation by RUNX2.R-HSA-8878166>TICAM1,TRAF6-dependent induction of TAK1 complex.R-HSA-9014325,TRAF6 mediated NF-kB activation.R-HSA-933542ITRAF6-mediated induction of TAK1 complex within TLR4 complex.R-HSA-9370722TRIF(TICAM1)-mediated TLR4 signaling .R-HSA-937061TRP channels.R-HSA-3295583#The NLRP3 inflammasome.R-HSA-844456.The activation of arylsulfatases.R-HSA-1663150JThe role of Nef in HIV-1 replication and disease pathogenesis.R-HSA-1649520Toll Like Receptor 4 (TLR4) Cascade.R-HSA-166016*Trafficking of AMPA receptors.R-HSA-399719;Trafficking of GluR2-containing AMPA receptors.R-HSA-4169931Transcrip< tional Regulation by VENTX.R-HSA-88538843SHC-related events triggered by IGF1R.R-HSA-2428933$O-linked glycosylation.R-HSA-51731055Phospholipase C-mediated cascade; FGFR4.R-HSA-5654228)Peptide hormone biosynthesis.R-HSA-209952(Peptide hormone metabolism.R-HSA-2980736-Peptide ligand-binding receptors.R-HSA-375276,Phase 0 - rapid depolarisation.R-HSA-5576892%Phase 2 - plateau phase.R-HSA-5576893[FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes.R-HSA-96150175Phospholipase C-mediated cascade; FGFR2.R-HSA-5654221#Physiological factors.R-HSA-5578768CPTK6 Regulates RTKs and Their Effectors AKT1 and DOK1.R-HSA-8849469)Plasma lipoprotein assembly.R-HSA-89638981Platelet Aggregation (Plug Formation).R-HSA-76009:Platelet activation, signaling and aggregation.R-HSA-76002$Platelet degranulation .R-HSA-1146088Post-translational protein phosphorylation.R-HSA-8957275(SHC-mediated cascade:FGFR4.R-HSA-5654719!PI-3K cascade:FGFR4.R-HSA-5654720Opsins.R-HSA-419771'Organic anion transporters.R-HSA-428643,Ovarian tumor domain proteases.R-HSA-5689896PCP-CE pathway.R-HSA-4086400 PECAM1 interactions.R-HSA-210990!PI-3K cascade:FGFR2.R-HSA-5654695PI3K Cascade.R-HSA-109704PTK6 Expression.R-HSA-8849473 PI3K-AKT activation.R-HSA-198203BPKA-mediated phosphorylation of key metabolic factors.R-HSA-163358-PKMTs methylate histone lysines.R-HSA-3214841EPP2A-mediated dephosphorylation of key metabolic factors.R-HSA-163767"PTK6 Down-Regulation.R-HSA-8849472;Postsynaptic nicotinic acetylcholine receptors.R-HSA-622327:Presynaptic nicotinic acetylcholine receptors.R-HSA-622323.Regulation of signaling by NODAL.R-HSA-1433617GRegulation of gene expression by Hypoxia-inducible Factor.R-HSA-12341588Regulation of gene expression in beta cells.R-HSA-210745NRegulation of gene expression in early pancreatic precursor cells.R-HSA-210747FRegulation of localization of FOXO transcription factors.R-HSA-96143992Regulation of necroptotic cell death.R-HSA-56754828Regulation of ornithine decarboxylase (ODC).R-HSA-350562Relaxin receptors.R-HSA-444821,Prolonged ERK activation events.R-HSA-1698938Response to elevated platelet cytosolic Ca2+.R-HSA-76005/Retrograde neurotrophin signalling.R-HSA-177504Reuptake of GABA.R-HSA-888593SDK interactions.R-HSA-373756(SHC-mediated cascade:FGFR2.R-HSA-5654699(SHC-mediated cascade:FGFR3.R-HSA-5654704_Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.R-HSA-4463880Regulation of beta-cell development.R-HSA-186712Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).R-HSA-381426)Regulation of IFNG signaling.R-HSA-877312;Proton-coupled neutral amino acid transporters.R-HSA-428559RAF activation.R-HSA-5673000/RAF-independent MAPK1-3 activation.R-HSA-112409'RHO GTPases activate PAKs.R-HSA-56271233RIP-mediated NFkB activation via ZBP1.R-HSA-1810476,RORA activates gene expression.R-HSA-1368082"Regulation by c-FLIP.R-HSA-3371378-Regulation of Complement cascade.R-HSA-977606HRegulation of FOXO transcriptional activity by acetylation.R-HSA-9617629HRegulation of Glucokinase by Glucokinase Regulatory Protein.R-HSA-170822=Regulation of HSF1-mediated heat shock response.R-HSA-3371453)FOXO-mediated transcription.R-HSA-9614085!Cam-PDE 1 activation.R-HSA-111957=FOXO-mediated transcription of cell death genes.R-HSA-96146573RHO GTPases regulate CFTR trafficking.R-HSA-5627083Opioid Signalling.R-HSA-111885+PERK regulates gene expression.R-HSA-381042-PI5P Regulates TP53 Acetylation.R-HSA-68115556Protein-protein interactions at synapses.R-HSA-6794362RET signaling.R-HSA-8853659:RHO GTPases Activate Rhotekin and Rhophilins.R-HSA-5666185'Neurexins and neuroligins.R-HSA-6794361(Nephrin family interactions.R-HSA-373753-Molybdenum cofactor biosynthesis.R-HSA-947581+NFG and proNGF binds to p75NTR.R-HSA-205017NGF processing.R-HSA-167060,NGF-independant TRKA activation.R-HSA-187024ANOTCH4 Intracellular Domain Regulates Transcription.R-HSA-90136953NTF4 activates NTRK2 (TRKB) signaling.R-HSA-9026357]Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.R-HSA-190840+Regulation of TP53 Expression.R-HSA-68047540Regulation of gap junction activity.R-HSA-191650?Regulation of pyruvate dehydrogenase (PDH) complex.R-HSA-204174+Regulation of signaling by CBL.R-HSA-912631:Response of EIF2AK1 (HRI) to heme deficiency.R-HSA-9648895AResponse of EIF2AK4 (GCN2) to amino acid deficiency.R-HSA-9633012Rho GTPase cycle.R-HSA-194840MRegulation of TP53 Activity through Association with Co-factors.R-HSA-68047599RUNX3 regulates BCL2L11 (BIM) transcription.R-HSA-8952158+Regulation of TNFR1 signaling.R-HSA-53579058Receptor-type tyrosine-protein phosphatases.R-HSA-3888442FGFRL1 modulation of FGFR1 signaling.R-HSA-56586233Degradation of GLI2 by the proteasome.R-HSA-56107831Blockage of phagosome acidification.R-HSA-9636467!Basigin interactions.R-HSA-2109916AKT phosphorylates targets in the cytosol.R-HSA-1983231Activated NTRK2 signals through FYN.R-HSA-90325002Activated NTRK2 signals through PI3K.R-HSA-90283351Activated NTRK2 signals through RAS.R-HSA-9026519AActivation of PUMA and translocation to mitochondria.R-HSA-1399152Aryl hydrocarbon receptor signalling.R-HSA-89371445Asymmetric localization of PCP proteins.R-HSA-4608870<Autodegradation of the E3 ubiquitin ligase COP1.R-HSA-349425%Death Receptor Signalling.R-HSA-73887-Disinhibition of SNARE formation.R-HSA-114516YGLI proteins bind promoters of Hh responsive genes to promote transcription.R-HSA-5635851Inhibition of PKR.R-HSA-169131&Insulin receptor recycling.R-HSA-77387*Keratan sulfate biosynthesis.R-HSA-2022854)Keratan sulfate degradation.R-HSA-20228570Keratan sulfate-keratin metabolism.R-HSA-1638074GLatent infection - Other responses of Mtb to phagocytosis.R-HSA-1222499(Endosomal-Vacuolar pathway.R-HSA-12369778Expression and Processing of Neurotrophins.R-HSA-9036866Complement cascade.R-HSA-166658;Cell surface interactions at the vascular wall.R-HSA-202733%Cell-Cell communication.R-HSA-1500931,Cell-cell junction organization.R-HSA-421270.Cellular response to heat stress.R-HSA-3371556*Cellular response to hypoxia.R-HSA-1234174 Choline catabolism.R-HSA-6798163.Chondroitin sulfate biosynthesis.R-HSA-2022870=Chondroitin sulfate-dermatan sulfate metabolism.R-HSA-17931851Class A-1 (Rhodopsin-like receptors).R-HSA-373076CClass C-3 (Metabotropic glutamate-pheromone receptors).R-HSA-420499+Clathrin-mediated endocytosis.R-HSA-88568289Collagen biosynthesis and modifying enzymes.R-HSA-1650814'Cell junction organization.R-HSA-446728KCaspase activation via extrinsic apoptotic signalling pathway.R-HSA-5357769MCaspase activation via Death Receptors in the presence of ligand.R-HSA-140534Autophagy.R-HSA-96129731Beta-catenin phosphorylation cascade.R-HSA-196299:Beta-oxidation of very long chain fatty acids.R-HSA-390247%Bicarbonate transporters.R-HSA-425381BBinding and Uptake of Ligands by Scavenger Receptors.R-HSA-2173782,C-type lectin receptors (CLRs).R-HSA-5621481)CASP8 activity is inhibited.R-HSA-5218900;Cargo trafficking to the periciliary membrane.R-HSA-5620920=COPI-independent Golgi-to-ER retrograde traffic.R-HSA-6811436COX reactions.R-HSA-140180*CREB3 factors activate genes.R-HSA-8874211CS-DS degradation.R-HSA-2024101 Cardiac conduction.R-HSA-5576891 Collagen formation.R-HSA-1474290?Constitutive Signaling by Aberrant PI3K in Cancer.R-HSA-2219530Signaling by MST1.R-HSA-8852405Creatine metabolism.R-HSA-712889Drug-mediated inhibition of ERBB2 signaling.R-HSA-9652282.ER to Golgi Anterograde Transport.R-HSA-199977!ERKs are inactivated.R-HSA-202670'Effects of PIP2 hydrolysis.R-HSA-114508Eicosanoids.R-HSA-211979%Elastic fibre formation.R-HSA-1566948IEvents associated with phagocytolytic activity of PMN cells.R-HSA-8941413/Extracellular matrix organization.R-HSA-14742441FGFR2b ligand binding and activation.R-HSA-1903771FGFR3b ligand< binding and activation.R-HSA-1903710FGFR4 ligand binding and activation.R-HSA-1903225Downstream signaling of activated FGFR4.R-HSA-56547165Downstream signaling of activated FGFR3.R-HSA-56547085Downstream signaling of activated FGFR2.R-HSA-5654696+Dermatan sulfate biosynthesis.R-HSA-2022923-Creation of C4 and C2 activators.R-HSA-1667869Cytochrome P450 - arranged by substrate type.R-HSA-211897 Degradation of DVL.R-HSA-4641258CDegradation of beta-catenin by the destruction complex.R-HSA-195253&Digestion and absorption.R-HSA-8963743'Digestion of dietary lipid.R-HSA-192456Digestion.R-HSA-8935690(Dimerization of procaspase-8.R-HSA-69416\Disassembly of the destruction complex and recruitment of AXIN to the membrane.R-HSA-4641262Dopamine receptors.R-HSA-390651Attenuation phase.R-HSA-3371568.Asparagine N-linked glycosylation.R-HSA-446203:Apoptotic cleavage of cell adhesion proteins.R-HSA-351906#The NLRP1 inflammasome.R-HSA-844455FTolerance by Mtb to nitric oxide produced by macrophages.R-HSA-1222538?Transport of connexins along the secretory pathway.R-HSA-190827:Transport of connexons to the plasma membrane.R-HSA-1908723VEGFR2 mediated vascular permeability.R-HSA-5218920/Sphingolipid de novo biosynthesis.R-HSA-1660661TNF signaling.R-HSA-758935TNFs bind their physiological receptors.R-HSA-5669034eNOS activation.R-HSA-203615*Acyl chain remodelling of PE.R-HSA-1482839*Acyl chain remodelling of PG.R-HSA-1482925*Acyl chain remodelling of PI.R-HSA-1482922*Acyl chain remodelling of PS.R-HSA-1482801,Adherens junctions interactions.R-HSA-418990Adrenoceptors.R-HSA-390696CActivation of kainate receptors upon glutamate binding.R-HSA-4513265Aflatoxin activation and detoxification.R-HSA-54236466Alpha-protein kinase 1 signaling pathway.R-HSA-9645460.Alternative complement activation.R-HSA-173736+Amine ligand-binding receptors.R-HSA-375280(Anchoring fibril formation.R-HSA-22143209Antiviral mechanism by IFN-stimulated genes.R-HSA-11694109Activation of Na-permeable kainate receptors.R-HSA-4513079Acetylcholine Neurotransmitter Release Cycle.R-HSA-2646421p75NTR recruits signalling complexes.R-HSA-2095436AKT phosphorylates targets in the nucleus.R-HSA-198693Acetylation.R-HSA-1565828Acetylcholine binding and downstream events.R-HSA-1814319Activation of NIMA Kinases NEK9, NEK6, NEK7.R-HSA-2980767Activation of AKT2.R-HSA-1651585Activation of AMPK downstream of NMDARs.R-HSA-96194838Activation of Ca-permeable Kainate Receptor.R-HSA-4513082tRNA processing in the mitochondrion.R-HSA-6785470Growth signallingDNA damage response TranscriptiontSupplementary Table 2. Gene expression pathway analysis of Werner syndrome and Hutchinson Gilford progeria syndrome. +1 36|9] = t?UA}DgGKM]P>5SVXb0[ L] _V9b`e#g|jSmor/ub*xzi \} j ւup(ŊdP / 9 ^ަYF/{5 NKW{= S6p Q s#wU)\Ohw \k  i x FUzeF1'  "$'*j-U/2 68w8;= @CsEGtJ;LO_QR T"WY\) _) adN}g (jlWo,q:Btva@y{m ccv<v@group_2_overlap_up_pathways732,.x/Users/krj951/My Drive/People/Cecilie and Maya/iPANDA_rare_diseases/overlap_spreadsheets/group_2_overlap_up_pathways.csv&&group 2 up!group_2_overlap_up_pathwaysW  PK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭V~&}"!ᇺ_Ν =r!sh ۴T**~ r׮+JOp'M:kүݭjkh [+wc5(_Zw:Mנ_^F֯A)v[_BJ Pl5 cFZԩnΕ(,cuc;P@$=9K !'> BLra)l)oڣh#CZ&beIĐD7 o߼9{og/^=eVe80_~n&_xw_?zоIwOG,:D?DĒ@!vnu6Y7=B>ı0]hq qޜOM#N\{7Ql9=M f-G8S Ǝ=%IJk 9l,k 4I @ʅH~-tx F]n }L-3CS">i}$CތM\[Ht)#,Ky ? v{"%t#LdM!GQ1w}k׺ O!QL×07c]YfGVvi`> X6I?!aW`=@v hT_"BOwxf(_nڼ UΙJpb/N aZG!jxqÕnAr.:M#߉H|nq7\OVlK:RRlkZha$9릫j}W^eu7=M/3\O//٨iG:3hgL(BO}<ь:g#$.Hxω {!J`4T@UK^vVx:lN:E5L+@2_/uR]ӻLf)낀 c3ĖDug`4 }kaQs/\e^Gn~" 8hGOμNO3b/" tMq]{*~ @ H~ @~ @ I~ @~ @ J~ @~ @ K~ @~ @ L~ @~ @   M~ @~  @   N~ @~ "@   O~ @~ $@   P~ @~ ?&@ ? ? ?Q~ ?@~ (@ R~ @~ *@ S~ @~ ,@ T~ @~ .@ U~ @~ 0@ V~ @~ >1@>> >W~ >@~ >2@>> >X~ >@~ 3@ Y~ @~ ?4@?? ?Z~ ?@~ 5@ [~ @~ 6@ \~ @~ 7@ ]~ @~ ?8@?? ?^~ ?@~ ?9@?? ?_~ ?@~ ?:@?? ?`~ ?@~ ?;@?? ?a~ ?@~ <@ b~ @~ ?=@?? ?c~ ?@D l8PPBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;%;&;';(;);*;+;,;-;.;/;0;1;2;3;4;5;6;7;8;9;:;;;<;=;>;?;~ >@   d~ @~ !?@!! !e~ !@~ "@@"" "f~ "@~ #@@## #g~ #@~ $A@$$ $h~ $@~ %A@%% %i~ %@~ &B@&& &j~ &@~ 'B@'' 'k~ '@~ (C@(( (l~ (@~ )C@)) )m~ )@~ *D@** *n~ *@~ +D@++ +o~ +@~ ,E@,, ,p~ ,@~ -E@-- -q~ -@~ .F@.. .r~ .@~ /F@// /s~ /@~ 0G@00 0t~ 0@~ 1?G@1?1? 1?u~ 1?@~ 2?H@2?2? 2?v~ 2?@~ 3?H@3?3? 3?w~ 3?@~ 4?I@4?4? 4?x~ 4?@~ 5?I@5?5? 5?y~ 5?@~ 6>J@6>6> 6>z~ 6>@~ 7>J@7>7> 7>{~ 7>@~ 8K@88 8|~ 8@~ 9K@99 9}~ 9@~ :L@:: :~~ :@~ ;L@;; ;~ ;@~ <?M@<?<? <?~ <?@~ =?M@=?=? =?~ =?@~ >N@>> >~ >@~ ?N@?? ?~ ?@D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB@;A;B;C;D;E;F;G;H;I;J;K;L;M;N;O;P;Q;R;S;T;U;V;W;X;Y;Z;[;\;];^;_;~ @O@@@ @~ @@~ AO@AA A~ A@~ BP@BB B~ B@~ C@P@CC C~ C@~ DP@DD D~ D@~ EP@EE E~ E@~ FQ@FF F~ F@~ G@Q@GG G~ G@~ HQ@HH H~ H@~ IQ@II I~ I@~ JR@JJ J~ J@~ K>@R@K>K> K>~ K>@~ L>R@L>L> L>~ L>@~ M>R@M>M> M>~ M>@~ N>S@N>N> N>~ N>@~ O>@S@O>O> O>~ O>@~ P>S@P>P> P>~ P>@~ QS@QQ Q~ Q@~ RT@RR R~ R@~ S@T@SS S~ S@~ TT@TT T~ T@~ U?T@U?U? U?~ U?@~ VU@VV V~ V@~ W?@U@W?W? W?~ W?@~ XU@XX X~ X@~ YU@YY Y~ Y@~ ZV@ZZ Z~ Z@~ [@V@[[ [~ [@~ \V@\\ \~ \@~ ]V@]] ]~ ]@~ ^W@^^ ^~ ^@~ _@W@__ _~ _@D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB`;a;b;c;d;e;f;g;h;i;j;k;l;m;n;o;p;q;r;s;t;u;v;w;x;y;z;{;|;};~;;~ `?W@`?`? `?~ `?@~ aW@aa a~ a@~ bX@bb b~ b@~ c@X@cc c~ c@~ dX@dd d~ d@~ eX@ee e~ e@~ fY@ff f~ f@~ g@Y@gg g~ g@~ hY@hh h~ h@~ iY@ii i~ i@~ jZ@jj j~ j@~ k@Z@kk k~ k@~ lZ@ll l~ l@~ m?Z@m?m? m?~ m?@~ n[@nn n~ n@~ o@[@oo o~ o@~ p[@pp p~ p@~ q[@qq q~ q@~ r\@rr r~ r@~ s@\@ss s~ s@~ t?\@t?t? t?~ t?@~ u\@uu u~ u@~ v]@vv v~ v@~ w?@]@w?w? w?~ w?@~ x]@xx x~ x@~ y]@yy y~ y@~ z^@zz zJ~ z?~ {@^@{{ {~ {?~ |^@|| |~ |?~ }^@}} }~ }?~ ~_@~~ ~~ ~?~ @_@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ _@ ~ ?~ _@ ~ ?~ `@ ~ ?~  `@ ~ ?~ @`@ *~ ?~ ``@ 3~ ?~ `@ _~ ?~ `@ ~ ?~ `@ ~ ?~ `@ ~ ?~ a@ V~ ?~  a@ U~ ?~ @a@ K~ ?~ `a@ `~ ?~ a@ ~ ?~ a@ j~ ?~ a@ ~ ?~ a@ R~ ?~ b@ Q~ ?~  b@ ~ ?~ @b@ 0~ ?~ `b@ ~ ?~ b@ ~ ?~ b@ ~ ?~ b@ ~ ?~ b@ ]~ ?~ c@ ~ ?~  c@ ~ ?~ @c@ (~ ?~ `c@ +~ ?~ c@ &~ ?~ c@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ c@ ~ ?~ c@ \~ ?~ d@ ~ ?~  d@ ~ ?~ @d@ ~ ?~ `d@ ~ ?~ d@ [~ ?~ d@ ~ ?~ d@ ~ ?~ d@ -~ ?~ e@ ~ ?~  e@ ~ ?~ @e@ ~ ?~ `e@ .~ ?~ e@ ~ ?~ e@ ^~ ?~ e@ /~ ?~ e@ ~ ?~ f@ ~ ?~  f@ Z~ ?~ @f@ ~ ?~ `f@ ~ ?~ f@ ~ ?~ f@ ~ ?~ f@ ~ ?~ f@ ~ ?~ g@ r~ ?~  g@ ~ ?~ @g@ ~ ?~ `g@ ~ ?~ g@ ~ ?~ g@ q~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ g@ ~ ?~ g@ m~ ?~ h@ ~ ?~  h@ l~ ?~ @h@ s~ ?~ `h@ ~ ?~ h@ ~ ?~ h@ ~ ?~ h@ ~ ?~ h@ ~ ?~ i@ ~ ?~  i@ ~ ?~ @i@ ~ ?~ `i@ ~ ?~ i@ n~ ?~ i@ ~ ?~ i@ ~ ?~ i@ ~ ?~ j@ ~ ?~  j@ p~ ?~ @j@ o~ ?~ `j@ ~ ?~ j@ ~ ?~ j@ ~ ?~ j@ ~ ?~ j@ ~ ?~ k@ ~ ?~  k@ ~ ?~ @k@ ~ ?~ `k@ ~ ?~ k@ k~ ?~ k@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ k@ ~ ?~ k@ ~ ?~ l@ ~ ?~  l@ ~ ?~ @l@ ~ ?~ `l@  ~ ?~ l@ c~ ?~ l@  ~ ?~ l@  ~ ?~ l@  ~ ?~ m@  ~ ?~  m@ O~ ?~ @m@ ~ ?~ `m@ ~ ?~ m@ ~ ?~ m@ ~ ?~ m@ {~ ?~ m@ ~ ?~ n@ y~ ?~  n@ ~ ?~ @n@ ~ ?~ `n@ ~ ?~ n@ u~ ?~ n@ v~ ?~ n@ ~ ?~ n@ w~ ?~ o@ ~ ?~  o@ ~ ?~ @o@ ~ ?~ `o@ ~ ?~ o@ ~ ?~ o@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;; ; ; ; ; ;;;;;;;;;;;;;;;;;;;~ o@ x~ ?~ o@ ~ ?~ p@ ~ ?~ p@ ~ ?~  p@ ~ ?~ 0p@ ~ ?~ @p@  ~ ?~ Pp@ !~ ?~ `p@ "~ ?~ pp@   ~ ?~ p@   #~ ?~ p@   $~ ?~ p@   %~ ?~ p@   &~ ?~ p@ '~ ?~ p@ (~ ?~ p@ )~ ?~ p@ *~ ?~ q@ +~ ?~ q@ ~ ?~  q@ ,~ ?~ 0q@ -~ ?~ @q@ ~ ?~ Pq@ .~ ?~ `q@ ~ ?~ pq@ /~ ?~ q@ 0~ ?~ q@ 1~ ?~ q@ ~ ?~ q@ 2~ ?~ q@ 3~ ?~ q@ 4~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;%;&;';(;);*;+;,;-;.;/;0;1;2;3;4;5;6;7;8;9;:;;;<;=;>;?;~ q@   ~ ?~ !q@!! !5~ !?~ "r@"" "6~ "?~ #r@## #~ #?~ $ r@$$ $~ $?~ %0r@%% %7~ %?~ &@r@&& &8~ &?~ 'Pr@'' '9~ '?~ (`r@(( (:~ (?~ )pr@)) );~ )?~ *r@** *~ *?~ +r@++ +<~ +?~ ,r@,, ,=~ ,?~ -r@-- ->~ -?~ .r@.. .?~ .?~ /r@// /@~ /?~ 0r@00 0A~ 0?~ 1r@11 1~ 1?~ 2s@22 2B~ 2?~ 3s@33 3~ 3?~ 4 s@44 4~ 4?~ 50s@55 5~ 5?~ 6@s@66 6C~ 6?~ 7Ps@77 7~ 7?~ 8`s@88 8~ 8?~ 9ps@99 9~ 9?~ :s@:: :D~ :?~ ;s@;; ;~ ;?~ <s@<< <E~ <?~ =s@== =F~ =?~ >s@>> >G~ >?~ ?s@?? ?H~ ??D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB@;A;B;C;D;E;F;G;H;I;J;K;L;M;N;O;P;Q;R;S;T;U;V;W;X;Y;Z;[;\;];^;_;~ @s@@@ @~ @?~ As@AA AI~ A?~ Bt@BB B~ B?~ Ct@CC C~ C?~ D t@DD D~ D?~ E0t@EE EJ~ E?~ F@t@FF FK~ F?~ GPt@GG GL~ G?~ H`t@HH HM~ H?~ Ipt@II IN~ I?~ Jt@JJ JO~ J?~ Kt@KK KP~ K?~ Lt@LL LQ~ L?~ Mt@MM MR~ M?~ Nt@NN NS~ N?~ Ot@OO OT~ O?~ Pt@PP PU~ P?~ Qt@QQ Q~ Q?~ Ru@RR RV~ R?~ Su@SS SW~ S?~ T u@TT TX~ T?~ U0u@UU UY~ U?~ V@u@VV VZ~ V?~ WPu@WW W[~ W?~ X`u@XX X\~ X?~ Ypu@YY Y]~ Y?~ Zu@ZZ Z^~ Z?~ [u@[[ [_~ [?~ \u@\\ \`~ \?~ ]u@]] ]a~ ]?~ ^u@^^ ^b~ ^?~ _u@__ _~ _?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB`;a;b;c;d;e;f;g;h;i;j;k;l;m;n;o;p;q;r;s;t;u;v;w;x;y;z;{;|;};~;;~ `u@`` `~ `?~ au@aa ac~ a?~ bv@bb bd~ b?~ cv@cc ce~ c?~ d v@dd df~ d?~ e0v@ee e~ e?~ f@v@ff f~ f?~ gPv@gg gg~ g?~ h`v@hh hh~ h?~ ipv@ii ii~ i?~ jv@jj jj~ j?~ kv@kk k~ k?~ lv@ll lk~ l?~ mv@mm ml~ m?~ nv@nn nm~ n?~ ov@oo on~ o?~ pv@pp po~ p?~ qv@qq qp~ q?~ rw@rr r~ r?~ sw@ss s~ s?~ t w@tt tq~ t?~ u0w@uu ur~ u?~ v@w@vv vs~ v?~ wPw@ww wt~ w?~ x`w@xx xu~ x?~ ypw@yy yv~ y?~ zw@zz z~ z?~ {w@{{ {w~ {?~ |w@|| |x~ |?~ }w@}} }y~ }?~ ~w@~~ ~z~ ~?~ w@ {~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ w@ ~ ?~ w@ |~ ?~ x@ }~ ?~ x@ ~~ ?~  x@ ~ ?~ 0x@ ~ ?~ @x@ ~ ?~ Px@ ~ ?~ `x@ ~ ?~ px@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ y@ ~ ?~ y@ ~ ?~  y@ ~ ?~ 0y@ ~ ?~ @y@ ~ ?~ Py@ ~ ?~ `y@ ~ ?~ py@ ~ ?~ y@ ~ ?~ y@ ~ ?~ y@ ~ ?~ y@ ~ ?~ y@ ~ ?~ y@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ y@ ~ ?~ y@ ~ ?~ z@ ~ ?~ z@ ~ ?~  z@ ~ ?~ 0z@ ~ ?~ @z@ ~ ?~ Pz@ ~ ?~ `z@ ~ ?~ pz@ ~ ?~ z@ ~ ?~ z@ ~ ?~ z@ 2~ ?~ z@ t~ ?~ z@ W~ ?~ z@ ~ ?~ z@ ~ ?~ z@ S~ ?~ {@ ~ ?~ {@ ~ ?~  {@ ~ ?~ 0{@ ~ ?~ @{@ ~ ?~ P{@ ~ ?~ `{@ ~ ?~ p{@ ~ ?~ {@ ~ ?~ {@ ~ ?~ {@ ~ ?~ {@ ~ ?~ {@ ~ ?~ {@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ {@ ~ ?~ {@ ~ ?~ |@ ~ ?~ |@ ~ ?~  |@ ~ ?~ 0|@ T~ ?~ @|@ X~ ?~ P|@ ~ ?~ `|@ Y~ ?~ p|@ ~ ?~ |@ ~ ?~ |@ W~ ?~ |@ ~ ?~ |@ ~ ?~ |@ ^~ ?~ |@ _~ ?~ |@ `~ ?~ |@ ~ ?~ }@ ~ ?~ }@ ~ ?~  }@ f~ ?~ 0}@ g~ ?~ @}@ ~ ?~ P}@ ~ ?~ `}@ R~ ?~ p}@ ~ ?~ }@ h~ ?~ }@ ~ ?~ }@ ]~ ?~ }@ ^~ ?~ }@ _~ ?~ }@ `~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ }@ b~ ?~ }@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~  ~@ r~ ?~ 0~@ ~ ?~ @~@ v~ ?~ P~@ w~ ?~ `~@ |~ ?~ p~@ ~~ ?~ ~@ C~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ 0~ ?~ @ 2~ ?~ @ 5~ ?~  @ 6~ ?~ 0@ 9~ ?~ @@ C~ ?~ P@ /~ ?~ `@ ~ ?~ p@ ~ ?~ @ ~ ?~ @ '~ ?~ @ *~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;; ; ; ; ; ;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@ ~ ?~ 0@  ~ ?~ 8@   ~ ?~ @@   ~ ?~ H@   ~ ?~ P@   ~ ?~ X@   ~ ?~ `@  ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ Ȁ@ ~ ?~ Ѐ@ ~ ?~ ؀@ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;%;&;';(;);*;+;,;-;.;/;0;1;2;3;4;5;6;7;8;9;:;;;<;=;>;?;~ @   ~ ?~ !@!! !~ !?~ "@"" "~ "?~ #@## #~ #?~ $@$$ $~ $?~ %@%% %~ %?~ & @&& &~ &?~ '(@'' '~ '?~ (0@(( (~ (?~ )8@)) )~ )?~ *@@** *~ *?~ +H@++ +~ +?~ ,P@,, ,~ ,?~ -X@-- -~ -?~ .`@.. .~ .?~ /h@// /~ /?~ 0p@00 0~ 0?~ 1x@11 1~ 1?~ 2@22 2~ 2?~ 3@33 3~ 3?~ 4@44 4~ 4?~ 5@55 5~ 5?~ 6@66 6~ 6?~ 7@77 7~ 7?~ 8@88 8~ 8?~ 9@99 9~ 9?~ :@:: :~ :?~ ;ȁ@;; ;~ ;?~ <Ё@<< <~ <?~ =؁@== =~ =?~ >@>> >~ >?~ ?@?? ?~ ??D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB@;A;B;C;D;E;F;G;H;I;J;K;L;M;N;O;P;Q;R;S;T;U;V;W;X;Y;Z;[;\;];^;_;~ @@@@ @I~ @?~ A@AA A4~ A?~ B@BB B~ B?~ C@CC C~ C?~ D@DD D~ D?~ E@EE E~ E?~ F @FF F~ F?~ G(@GG G~ G?~ H0@HH H~ H?~ I8@II I~ I?~ J@@JJ JD~ J?~ KH@KK K~ K?~ LP@LL L~ L?~ MX@MM M~ M?~ N`@NN N~ N?~ Oh@OO O~ O?~ Pp@PP P~ P?~ Qx@QQ Q~ Q?~ R@RR R~ R?~ S@SS SG~ S?~ T@TT T~ T?~ U@UU U~ U?~ V@VV V~ V?~ W@WW W~ W?~ X@XX X~ X?~ Y@YY Y~ Y?~ Z@ZZ Z~ Z?~ [Ȃ@[[ [~ [?~ \Ђ@\\ \~ \?~ ]؂@]] ]~ ]?~ ^@^^ ^~ ^?~ _@__ _ ~ _?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB`;a;b;c;d;e;f;g;h;i;j;k;l;m;n;o;p;q;r;s;t;u;v;w;x;y;z;{;|;};~;;~ `@`` `!~ `?~ a@aa a~ a?~ b@bb b~ b?~ c@cc c~ c?~ d@dd d~ d?~ e@ee e~ e?~ f @ff f~ f?~ g(@gg g$~ g?~ h0@hh h%~ h?~ i8@ii i~ i?~ j@@jj j~ j?~ kH@kk k~ k?~ lP@ll l~ l?~ mX@mm m~ m?~ n`@nn n~ n?~ oh@oo o~ o?~ pp@pp p~ p?~ qx@qq q1~ q?~ r@rr r~ r?~ s@ss s~ s?~ t@tt t~ t?~ u@uu u~ u?~ v@vv v~ v?~ w@ww w~ w?~ x@xx x~ x?~ y@yy y~ y?~ z@zz z~ z?~ {ȃ@{{ {~ {?~ |Ѓ@|| |~ |?~ }؃@}} }~ }?~ ~@~~ ~~ ~?~ @ A~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @  ~ ?~ (@ @~ ?~ 0@ B~ ?~ 8@  ~ ?~ @@  ~ ?~ H@ 8~ ?~ P@ ~ ?~ X@  ~ ?~ `@ &~ ?~ h@ '~ ?~ p@ )~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @  ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ O~ ?~ Ȅ@  ~ ?~ Є@ ~ ?~ ؄@ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ *~ ?~ @ ~ ?~ @ +~ ?~  @ @~ ?~ (@ >~ ?~ 0@ ~ ?~ 8@ ~ ?~ @@ ~ ?~ H@ ~ ?~ P@ ~ ?~ X@ ~ ?~ `@ ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ <~ ?~ @ ~ ?~ @ 0~ ?~ @ ~ ?~ @  ~ ?~ @ 1~ ?~ ȅ@ ~ ?~ Ѕ@ !~ ?~ ؅@ 5~ ?~ @ "~ ?~ @ #~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;~ @ $~ ?~ @ %~ ?~ @ &~ ?~ @ '~ ?~ @ 8~ ?~ @ 9~ ?~  @ :~ ?~ (@ (~ ?BBBBBBB>@ *Igroup_2_overlap_up_pathways 0group_2_overlap_up_pathways[C7,.x/Users/krj951/My Drive/People/Cecilie and Maya/iPANDA_rare_diseases/overlap_spreadsheets/group_2_overlap_up_pathways.csvggD ZO Cˉ %-5=EMU]em$u/}:EP[fq|ŝͨճݾ W  dMbP?_*+%;&?'?(?)?";??& U}  } ?}  } `}  C;;;;;;;;; ; ; ; ; ;;;;;;;;;;;;;;;;;;;    ~  ~ @ >*~ @?@@ @~ @@ @+~ @ ~ @~ @ ~ @~ @ ~ @~ >@>> > ~ >@~ >@>> > ~ >@~ @  ~ @~ > @ > > > ~ >@~ "@    ~ @~ >$@ > > >~ >@~ &@   ~ @~ >(@ > > >~ >@~ @*@@@ @~ @@~ >,@>> >~ >@~ >.@>> >~ >@~ 0@ ~ @~ 1@ ~ @~ 2@ ~ @~ 3@ ~ @~ 4@ ~ @~ 5@ ~ @~ 6@ ~ @~ 7@ ~ @~ @8@@@ @~ @@~ 9@ ~ @~ :@ ~ @~ ;@ ~ @~ <@  ~ @~ =@ !~ @~ >@ "~ @D l8PPBBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;%;&;';(;);*;+;,;-;.;/;0;1;2;3;4;5;6;7;8;9;:;;;<;=;>;?;~ ?@   #~ @~ !>@@!>!> !>$~ !>@~ ">@@">"> ">%~ ">@~ #A@## #&~ #@~ $A@$$ $'~ $@~ %B@%% %(~ %@~ &B@&& &)~ &@~ 'C@'' '*~ '@~ (C@(( (+~ (@~ )D@)) ),~ )@~ *D@** *-~ *@~ +@E@+@+@ +@.~ +@@~ ,@E@,@,@ ,@/~ ,@@~ -F@-- -0~ -@~ .F@.. .1~ .@~ /G@// /2~ /@~ 0>G@0>0> 0>3~ 0>@~ 1>H@1>1> 1>4~ 1>@~ 2>H@2>2> 2>5~ 2>@~ 3I@33 36~ 3@~ 4>I@4>4> 4>7~ 4>@~ 5>J@5>5> 5>8~ 5>@~ 6>J@6>6> 6>9~ 6>@~ 7K@77 7:~ 7@~ 8K@88 8;~ 8@~ 9L@99 9<~ 9@~ :L@:: :=~ :@~ ;M@;; ;>~ ;@~ <M@<< <?~ <@~ =N@== =@~ =@~ >N@>> >A~ >@~ ?O@?? ?B~ ?@D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB@;A;B;C;D;E;F;G;H;I;J;K;L;M;N;O;P;Q;R;S;T;U;V;W;X;Y;Z;[;\;];^;_;~ @O@@@ @C~ @@~ AP@AA AD~ A@~ B@P@BB BE~ B@~ CP@CC CF~ C@~ D>P@D>D> D>G~ D>@~ E>Q@E>E> E>H~ E>@~ F@Q@FF FI~ F@~ G>Q@G>G> G>J~ G>@~ HQ@HH HK~ H@~ IR@II IL~ I@~ J>@R@J>J> J>M~ J>@~ KR@KK KN~ K@~ L>R@L>L> L>O~ L>@~ M>S@M>M> M>P~ M>@~ N@S@NN NQ~ N@~ OS@OO OR~ O@~ PS@PP PS~ P@~ QT@QQ QT~ Q@~ R@T@RR RU~ R@~ ST@SS SV~ S@~ TT@TT TW~ T@~ UU@UU UX~ U@~ V@U@VV VY~ V@~ WU@WW WZ~ W@~ XU@XX X[~ X@~ Y>V@Y>Y> Y>\~ Y>@~ Z>@V@Z>Z> Z>]~ Z>@~ [V@[[ [^~ [@~ \V@\\ \_~ \@~ ]W@]] ]`~ ]@~ ^@W@^^ ^a~ ^@~ _W@__ _b~ _@D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB`;a;b;c;d;e;f;g;h;i;j;k;l;m;n;o;p;q;r;s;t;u;v;w;x;y;z;{;|;};~;;~ `W@`` `c~ `@~ a>X@a>a> a>d~ a>@~ b>@X@b>b> b>e~ b>@~ c>X@c>c> c>f~ c>@~ d>X@d>d> d>g~ d>@~ e>Y@e>e> e>h~ e>@~ f@Y@ff fi~ f@~ gY@gg gj~ g@~ hY@hh hk~ h@~ iZ@ii il~ i@~ j@Z@jj jm~ j@~ kZ@kk kn~ k@~ lZ@ll lo~ l@~ m[@mm mp~ m@~ n@[@nn nq~ n@~ o[@oo or~ o@~ p>[@p>p> p>s~ p>@~ q\@qq qt~ q@~ r@\@rr ru~ r@~ s\@ss sv~ s@~ t\@tt tw~ t@~ u]@uu ux~ u@~ v@]@vv vy~ v@~ w>]@w>w> w>z~ w>@~ x>]@x>x> x>{~ x>@~ y>^@y>y> y>|~ y>@~ z@^@zz z}~ z@~ {^@{{ {~~ {@~ |^@|| |~ |@~ }_@}} }~ }@~ ~@_@~~ ~~ ~@~ _@ ~ @D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ _@ ~ @~ `@ ~ @~  `@ ~ @~ @`@ ~ @~ >``@>> >~ >@~ `@ ~ @~ `@ ~ @~ `@ ~ @~ `@ ~ @~ >a@>> >~ >@~ > a@>> >~ >@~ >@a@>> >~ >@~ `a@ ~ @~ a@ ~ @~ a@ ~ @~ a@ ~ @~ a@ ~ @~ b@ ~ @~  b@ ~ @~ @b@ ~ @~ `b@ ~ @~ b@ ~ @~ >b@>> >~ >@~ b@ ~ @~ b@ ~ @~ c@ ~ @~  c@ ~ @~ >@c@>> >~ >@~ >`c@>> >~ >@~ >c@>> >~ >@~ >c@>> >~ >@~ >c@>> >~ >@D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ c@ ~ @~ d@ ~ @~  d@ ~ @~ @d@ ~ @~ `d@ ~ @~ d@ ~ @~ d@ ~ @~ d@ ~ @~ d@ ~ @~ >e@>> >~ >@~  e@ ~ @~ @e@ ~ @~ `e@ ~ @~ e@ ~ @~ e@ ~ @~ e@ ~ @~ e@ ~ @~ f@ ~ @~  f@ ~ @~ @f@ ~ @~ >`f@>> >~ >@~ >f@>> >~ >@~ f@ ~ @~ f@ ~ @~ f@ ~ @~ g@ ~ @~ > g@>> >~ >@~ @g@ ~ @~ `g@ ~ @~ g@ ~ @~ g@ ~ @~ g@ ~ @D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ >g@>> >~ >@~ >h@>> >~ >@~  h@ ~ @~ >@h@>> >~ >@~ >`h@>> >~ >@~ >h@>> >~ >@~ >h@>> >~ >@~ >h@>> >~ >@~ >h@>> >~ >@~ >i@>> >~ >@~  i@ ~ @~ >@i@>> >~ >@~ `i@ ~ @~ i@ ~ @~ i@ ~ @~ i@ ~ @~ i@ ~ @~ j@ ~ @~  j@ ~ @~ @j@ ~ @~ `j@ ~ @~ >j@>> >~ >@~ >j@>> >~ >@~ >j@>> >~ >@~ >j@>> >~ >@~ >k@>> >~ >@~ > k@>> >~ >@~ >@k@>> >~ >@~ `k@ ~ @~ >k@>> >~ >@~ >k@>> >~ >@~ k@ ~ @D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ k@ ~ @~ >l@>> >~ >@~ > l@>> >~ >@~ @l@ ~ @~ `l@ ~ @~ l@ ~ @~ l@ ~ @~ l@ ~ @~ l@ ~ @~ m@ ~ @~  m@ ~ @~ @m@ ~ @~ `m@ ~ @~ m@ ~ @~ m@ ~ @~ >m@>> >~ >@~ m@ ~ @~ n@ ~ @~ > n@>> >~ >@~ @n@ ~ @~ `n@ ~ @~ n@ ~ @~ n@ ~ @~ n@ ~ @~ n@ ~ @~ o@ ~ @~  o@ ~ @~ @o@ ~ @~ `o@ ~ @~ >o@>> >~ >@~ >o@>> >~ >@~ o@ ~ @D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;; ; ; ; ; ;;;;;;;;;;;;;;;;;;;~ o@ ~ @~ p@ ~ @~ p@ ~ @~  p@ ~ @~ 0p@ ~ @~ >@p@>> >~ >@~ >Pp@>> > ~ >@~ `p@  ~ @~ >pp@>> > ~ >@~ p@    ~ @~ p@    ~ @~ p@   ~ @~ >p@ > > >~ >@~ p@   ~ @~ >p@>> >~ >@~ >p@>> >~ >@~ >p@>> >~ >@~ q@ ~ @~ q@ ~ @~  q@ ~ @~ 0q@ ~ @~ @q@ ~ @~ Pq@ ~ @~ >`q@>> >~ >@~ pq@ ~ @~ q@ ~ @~ q@ ~ @~ q@ ~ @~ >q@>> >~ >@~ >q@>> > ~ >@~ >q@>> >!~ >@~ q@ "~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;%;&;';(;);*;+;,;-;.;/;0;1;2;3;4;5;6;7;8;9;:;;;<;=;>;?;~ q@   #~ ?~ !r@!! !$~ !?~ "r@"" "%~ "?~ # r@## #&~ #?~ $0r@$$ $'~ $?~ %@r@%% %(~ %?~ &Pr@&& &)~ &?~ '`r@'' '*~ '?~ (pr@(( (+~ (?~ )r@)) ),~ )?~ *r@** *-~ *?~ +r@++ +.~ +?~ ,r@,, ,/~ ,?~ -r@-- -0~ -?~ .r@.. .1~ .?~ /r@// /2~ /?~ 0r@00 03~ 0?~ 1s@11 14~ 1?~ 2s@22 25~ 2?~ 3 s@33 36~ 3?~ 40s@44 47~ 4?~ 5@s@55 58~ 5?~ 6Ps@66 69~ 6?~ 7`s@77 7:~ 7?~ 8ps@88 8;~ 8?~ 9s@99 9<~ 9?~ :s@:: :=~ :?~ ;s@;; ;>~ ;?~ <s@<< <?~ <?~ =s@== =@~ =?~ >s@>> >A~ >?~ ?s@?? ?B~ ??D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB@;A;B;C;D;E;F;G;H;I;J;K;L;M;N;O;P;Q;R;S;T;U;V;W;X;Y;Z;[;\;];^;_;~ @s@@@ @C~ @?~ At@AA AD~ A?~ Bt@BB BE~ B?~ C t@CC CF~ C?~ D0t@DD DG~ D?~ E@t@EE EH~ E?~ FPt@FF FI~ F?~ G`t@GG GJ~ G?~ Hpt@HH HK~ H?~ It@II IL~ I?~ Jt@JJ JM~ J?~ Kt@KK KN~ K?~ Lt@LL LO~ L?~ Mt@MM MP~ M?~ Nt@NN NQ~ N?~ Ot@OO OR~ O?~ Pt@PP PS~ P?~ Qu@QQ QT~ Q?~ Ru@RR RU~ R?~ S u@SS SV~ S?~ T0u@TT TW~ T?~ U@u@UU UX~ U?~ VPu@VV VY~ V?~ W`u@WW WZ~ W?~ Xpu@XX X[~ X?~ Yu@YY Y\~ Y?~ Zu@ZZ Z]~ Z?~ [u@[[ [^~ [?~ \u@\\ \_~ \?~ ]u@]] ]`~ ]?~ ^u@^^ ^a~ ^?~ _u@__ _b~ _?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB`;a;b;c;d;e;f;g;h;i;j;k;l;m;n;o;p;q;r;s;t;u;v;w;x;y;z;{;|;};~;;~ `u@`` `c~ `?~ av@aa ad~ a?~ bv@bb be~ b?~ c v@cc cf~ c?~ d0v@dd dg~ d?~ e@v@ee eh~ e?~ fPv@ff fi~ f?~ g`v@gg gj~ g?~ hpv@hh hk~ h?~ iv@ii il~ i?~ jv@jj jm~ j?~ kv@kk kn~ k?~ lv@ll lo~ l?~ mv@mm mp~ m?~ nv@nn nq~ n?~ ov@oo or~ o?~ pv@pp ps~ p?~ qw@qq qt~ q?~ rw@rr ru~ r?~ s w@ss sv~ s?~ t0w@tt tw~ t?~ u@w@uu ux~ u?~ vPw@vv vy~ v?~ w`w@ww wz~ w?~ xpw@xx x{~ x?~ yw@yy y|~ y?~ zw@zz z}~ z?~ {w@{{ {~~ {?~ |w@|| |~ |?~ }w@}} }~ }?~ ~w@~~ ~~ ~?~ w@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ w@ ~ ?~ x@ ~ ?~ x@ ~ ?~  x@ ~ ?~ 0x@ ~ ?~ @x@ ~ ?~ Px@ ~ ?~ `x@ ~ ?~ px@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ x@ ~ ?~ y@ ~ ?~ y@ ~ ?~  y@ ~ ?~ 0y@ ~ ?~ @y@ ~ ?~ Py@ ~ ?~ `y@ ~ ?~ py@ ~ ?~ y@ ~ ?~ y@ ~ ?~ y@ ~ ?~ y@ ~ ?~ y@ ~ ?~ y@ ~ ?~ y@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ y@ ~ ?~ z@ ~ ?~ z@ ~ ?~  z@ ~ ?~ 0z@ ~ ?~ @z@ ~ ?~ Pz@ ~ ?~ `z@ ~ ?~ pz@ ~ ?~ z@ ~ ?~ z@ ~ ?~ z@ ~ ?~ z@ ~ ?~ z@ ~ ?~ z@ ~ ?~ z@ ~ ?~ z@ ~ ?~ {@ ~ ?~ {@ ~ ?~  {@ ~ ?~ 0{@ ~ ?~ @{@ ~ ?~ P{@ ~ ?~ `{@ ~ ?~ p{@ ~ ?~ {@ ~ ?~ {@ ~ ?~ {@ ~ ?~ {@ ~ ?~ {@ ~ ?~ {@ ~ ?~ {@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ {@ ~ ?~ |@ ~ ?~ |@ ~ ?~  |@ ~ ?~ 0|@ ~ ?~ @|@ ~ ?~ P|@ ~ ?~ `|@ ~ ?~ p|@ ~ ?~ |@ ~ ?~ |@ ~ ?~ |@ ~ ?~ |@ ~ ?~ |@ ~ ?~ |@ ~ ?~ |@ ~ ?~ |@ ~ ?~ }@ ~ ?~ }@ ~ ?~  }@ ~ ?~ 0}@ ~ ?~ @}@ ~ ?~ P}@ ~ ?~ `}@ ~ ?~ p}@ ~ ?~ }@ ~ ?~ }@ ~ ?~ }@ ~ ?~ }@ ~ ?~ }@ ~ ?~ }@ ~ ?~ }@ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ }@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~  ~@ ~ ?~ 0~@ ~ ?~ @~@ ~ ?~ P~@ ~ ?~ `~@ ~ ?~ p~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ ~@ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ 0@ ~ ?~ @@ ~ ?~ P@ ~ ?~ `@ ~ ?~ p@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;; ; ; ; ; ;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@  ~ ?~ 0@  ~ ?~ 8@  ~ ?~ @@    ~ ?~ H@    ~ ?~ P@   ~ ?~ X@   ~ ?~ `@   ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ Ȁ@ ~ ?~ Ѐ@ ~ ?~ ؀@ ~ ?~ @  ~ ?~ @ !~ ?~ @ "~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;%;&;';(;);*;+;,;-;.;/;0;1;2;3;4;5;6;7;8;9;:;;;<;=;>;?;~ @   #~ ?~ !@!! !$~ !?~ "@"" "%~ "?~ #@## #&~ #?~ $@$$ $'~ $?~ % @%% %(~ %?~ &(@&& &)~ &?~ '0@'' '*~ '?~ (8@(( (+~ (?~ )@@)) ),~ )?~ *H@** *-~ *?~ +P@++ +.~ +?~ ,X@,, ,/~ ,?~ -`@-- -0~ -?~ .h@.. .1~ .?~ /p@// /2~ /?~ 0x@00 03~ 0?~ 1@11 14~ 1?~ 2@22 25~ 2?~ 3@33 36~ 3?~ 4@44 47~ 4?~ 5@55 58~ 5?~ 6@66 69~ 6?~ 7@77 7:~ 7?~ 8@88 8;~ 8?~ 9@99 9<~ 9?~ :ȁ@:: :=~ :?~ ;Ё@;; ;>~ ;?~ <؁@<< <?~ <?~ =@== =@~ =?~ >@>> >A~ >?~ ?@?? ?B~ ??D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB@;A;B;C;D;E;F;G;H;I;J;K;L;M;N;O;P;Q;R;S;T;U;V;W;X;Y;Z;[;\;];^;_;~ @@@@ @C~ @?~ A@AA AD~ A?~ B@BB BE~ B?~ C@CC CF~ C?~ D@DD DG~ D?~ E @EE EH~ E?~ F(@FF FI~ F?~ G0@GG GJ~ G?~ H8@HH HK~ H?~ I@@II IL~ I?~ JH@JJ JM~ J?~ KP@KK KN~ K?~ LX@LL LO~ L?~ M`@MM MP~ M?~ Nh@NN NQ~ N?~ Op@OO OR~ O?~ Px@PP PS~ P?~ Q@QQ QT~ Q?~ R@RR RU~ R?~ S@SS SV~ S?~ T@TT TW~ T?~ U@UU UX~ U?~ V@VV VY~ V?~ W@WW WZ~ W?~ X@XX X[~ X?~ Y@YY Y\~ Y?~ ZȂ@ZZ Z]~ Z?~ [Ђ@[[ [^~ [?~ \؂@\\ \_~ \?~ ]@]] ]`~ ]?~ ^@^^ ^a~ ^?~ _@__ _b~ _?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB`;a;b;c;d;e;f;g;h;i;j;k;l;m;n;o;p;q;r;s;t;u;v;w;x;y;z;{;|;};~;;~ `@`` `c~ `?~ a@aa ad~ a?~ b@bb be~ b?~ c@cc cf~ c?~ d@dd dg~ d?~ e @ee eh~ e?~ f(@ff fi~ f?~ g0@gg gj~ g?~ h8@hh hk~ h?~ i@@ii il~ i?~ jH@jj jm~ j?~ kP@kk kn~ k?~ lX@ll lo~ l?~ m`@mm mp~ m?~ nh@nn nq~ n?~ op@oo or~ o?~ px@pp ps~ p?~ q@qq qt~ q?~ r@rr ru~ r?~ s@ss sv~ s?~ t@tt tw~ t?~ u@uu ux~ u?~ v@vv vy~ v?~ w@ww wz~ w?~ x@xx x{~ x?~ y@yy y|~ y?~ zȃ@zz z}~ z?~ {Ѓ@{{ {~~ {?~ |؃@|| |~ |?~ }@}} }~ }?~ ~@~~ ~~ ~?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@ ~ ?~ 0@ ~ ?~ 8@ ~ ?~ @@ ~ ?~ H@ ~ ?~ P@ ~ ?~ X@ ~ ?~ `@ ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ Ȅ@ ~ ?~ Є@ ~ ?~ ؄@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@ ~ ?~ 0@ ~ ?~ 8@ ~ ?~ @@ ~ ?~ H@ ~ ?~ P@ ~ ?~ X@ ~ ?~ `@ ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ ȅ@ ~ ?~ Ѕ@ ~ ?~ ؅@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@ ~ ?~ 0@ ~ ?~ 8@ ~ ?~ @@ ~ ?~ H@ ~ ?~ P@ ~ ?~ X@ ~ ?~ `@ ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ Ȇ@ ~ ?~ І@ ~ ?~ ؆@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@ ~ ?~ 0@ ~ ?~ 8@ ~ ?~ @@ ~ ?~ H@ ~ ?~ P@ ~ ?~ X@ ~ ?~ `@ ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ ȇ@ ~ ?~ Ї@ ~ ?~ ؇@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;; ; ; ; ; ;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@  ~ ?~ 0@  ~ ?~ 8@  ~ ?~ @@    ~ ?~ H@    ~ ?~ P@   ~ ?~ X@   ~ ?~ `@   ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ Ȉ@ ~ ?~ Ј@ ~ ?~ ؈@ ~ ?~ @  ~ ?~ @ !~ ?~ @ "~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;%;&;';(;);*;+;,;-;.;/;0;1;2;3;4;5;6;7;8;9;:;;;<;=;>;?;~ @   #~ ?~ !@!! !$~ !?~ "@"" "%~ "?~ #@## #&~ #?~ $@$$ $'~ $?~ % @%% %(~ %?~ &(@&& &)~ &?~ '0@'' '*~ '?~ (8@(( (+~ (?~ )@@)) ),~ )?~ *H@** *-~ *?~ +P@++ +.~ +?~ ,X@,, ,/~ ,?~ -`@-- -0~ -?~ .h@.. .1~ .?~ /p@// /2~ /?~ 0x@00 03~ 0?~ 1@11 14~ 1?~ 2@22 25~ 2?~ 3@33 36~ 3?~ 4@44 47~ 4?~ 5@55 58~ 5?~ 6@66 69~ 6?~ 7@77 7:~ 7?~ 8@88 8;~ 8?~ 9@99 9<~ 9?~ :ȉ@:: :=~ :?~ ;Љ@;; ;>~ ;?~ <؉@<< <?~ <?~ =@== =@~ =?~ >@>> >A~ >?~ ?@?? ?B~ ??D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB@;A;B;C;D;E;F;G;H;I;J;K;L;M;N;O;P;Q;R;S;T;U;V;W;X;Y;Z;[;\;];^;_;~ @@@@ @C~ @?~ A@AA AD~ A?~ B@BB BE~ B?~ C@CC CF~ C?~ D@DD DG~ D?~ E @EE EH~ E?~ F(@FF FI~ F?~ G0@GG GJ~ G?~ H8@HH HK~ H?~ I@@II IL~ I?~ JH@JJ JM~ J?~ KP@KK KN~ K?~ LX@LL LO~ L?~ M`@MM MP~ M?~ Nh@NN NQ~ N?~ Op@OO OR~ O?~ Px@PP PS~ P?~ Q@QQ QT~ Q?~ R@RR RU~ R?~ S@SS SV~ S?~ T@TT TW~ T?~ U@UU UX~ U?~ V@VV VY~ V?~ W@WW WZ~ W?~ X@XX X[~ X?~ Y@YY Y\~ Y?~ ZȊ@ZZ Z]~ Z?~ [Њ@[[ [^~ [?~ \؊@\\ \_~ \?~ ]@]] ]`~ ]?~ ^@^^ ^a~ ^?~ _@__ _b~ _?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB`;a;b;c;d;e;f;g;h;i;j;k;l;m;n;o;p;q;r;s;t;u;v;w;x;y;z;{;|;};~;;~ `@`` `c~ `?~ a@aa ad~ a?~ b@bb be~ b?~ c@cc cf~ c?~ d@dd dg~ d?~ e @ee eh~ e?~ f(@ff fi~ f?~ g0@gg gj~ g?~ h8@hh hk~ h?~ i@@ii il~ i?~ jH@jj jm~ j?~ kP@kk kn~ k?~ lX@ll lo~ l?~ m`@mm mp~ m?~ nh@nn nq~ n?~ op@oo or~ o?~ px@pp ps~ p?~ q@qq qt~ q?~ r@rr ru~ r?~ s@ss sv~ s?~ t@tt tw~ t?~ u@uu ux~ u?~ v@vv vy~ v?~ w@ww wz~ w?~ x@xx x{~ x?~ y@yy y|~ y?~ zȋ@zz z}~ z?~ {Ћ@{{ {~~ {?~ |؋@|| |~ |?~ }@}} }~ }?~ ~@~~ ~~ ~?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@ ~ ?~ 0@ ~ ?~ 8@ ~ ?~ @@ ~ ?~ H@ ~ ?~ P@ ~ ?~ X@ ~ ?~ `@ ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ Ȍ@ ~ ?~ Ќ@ ~ ?~ ،@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@ ~ ?~ 0@ ~ ?~ 8@ ~ ?~ @@ ~ ?~ H@ ~ ?~ P@ ~ ?~ X@ ~ ?~ `@ ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ ȍ@ ~ ?~ Ѝ@ ~ ?~ ؍@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@ ~ ?~ 0@ ~ ?~ 8@ ~ ?~ @@ ~ ?~ H@ ~ ?~ P@ ~ ?~ X@ ~ ?~ `@ ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ Ȏ@ ~ ?~ Ў@ ~ ?~ ؎@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ (@ ~ ?~ 0@ ~ ?~ 8@ ~ ?~ @@ ~ ?~ H@ ~ ?~ P@ ~ ?~ X@ ~ ?~ `@ ~ ?~ h@ ~ ?~ p@ ~ ?~ x@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~ ȏ@ ~ ?~ Џ@ ~ ?~ ؏@ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB;;;;;;;;; ; ; ; ; ;;;;;;;;;;;;;;;;;;;~ @ ~ ?~ @ ~ ?~ @ ~ ?~ @ ~ ?~  @ ~ ?~ @ ~ ?~ @  ~ ?~ @  ~ ?~ @  ~ ?~  @    ~ ?~ $@    ~ ?~ (@   ~ ?~ ,@   ~ ?~ 0@   ~ ?~ 4@ ~ ?~ 8@ ~ ?~ <@ ~ ?~ @@ ~ ?~ D@ ~ ?~ H@ ~ ?~ L@ ~ ?~ P@ ~ ?~ T@ ~ ?~ X@ ~ ?~ \@ ~ ?~ `@ ~ ?~ d@ ~ ?~ h@ ~ ?~ l@ ~ ?~ p@  ~ ?~ t@ !~ ?~ x@ "~ ?D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB ;!;";#;$;%;&;';(;);*;+;,;-;.;/;0;1;2;3;4;5;6;7;8;9;:;;;<;=;>;?;~ |@   #~ ?~ !@!! !$~ !?~ "@"" "%~ "?~ #@## #&~ #?~ $@$$ $'~ $?~ %@%% %(~ %?~ &@&& &)~ &?~ '@'' '*~ '?~ (@(( (+~ (?~ )@)) ),~ )?~ *@** *-~ *?~ +@++ +.~ +?~ ,@,, ,/~ ,?~ -@-- -0~ -?~ .@.. .1~ .?~ /@// /2~ /?~ 0@00 03~ 0?~ 1@11 14~ 1?~ 2Đ@22 25~ 2?~ 3Ȑ@33 36~ 3?~ 4̐@44 47~ 4?~ 5А@55 58~ 5?~ 6Ԑ@66 69~ 6?~ 7ؐ@77 7:~ 7?~ 8ܐ@88 8;~ 8?~ 9@99 9<~ 9?~ :@:: :=~ :?~ ;@;; ;>~ ;?~ <@<< <?~ <?~ =@== =@~ =?~ >@>> >A~ >?~ ?@?? ?B~ ??D lBBBBBBBBBBBBBBBBBBBBBBBBBBBBBBB@;A;B;~ @@@@ @C~ @?~ A@AA AD~ A?~ B@BB BE~ B? (BB>i@BB ggD Oh+'08@T x  Envisage 09Microsoft Macintosh Excel@DҴ@(;H ՜.+,0 HP X`hp x   group 2 upgroup_2_overlap_down_pathways)'group 2 up'!group_2_overlap_up_pathways  Worksheets Named Ranges  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~      !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~    Root Entry F'1OIWorkbookSummaryInformation(DocumentSummaryInformation8