ࡱ>  ZO\pVelisage 09 Ba==qf-8X@"1Calibri1Calibri1Calibri1Calibri1Calibri1 Calibri1Calibri14Calibri1 Calibri1Calibri1Calibri1,6Calibri16Calibri16Calibri1>Calibri14Calibri1<Calibri1?Calibri1*h6 Calibri Light1Calibri1 Calibri"$"#,##0_);\("$"#,##0\)!"$"#,##0_);[Red]\("$"#,##0\)""$"#,##0.00_);\("$"#,##0.00\)'""$"#,##0.00_);[Red]\("$"#,##0.00\)7*2_("$"* #,##0_);_("$"* \(#,##0\);_("$"* "-"_);_(@_).))_(* #,##0_);_(* \(#,##0\);_(* "-"_);_(@_)?,:_("$"* #,##0.00_);_("$"* \(#,##0.00\);_("$"* "-"??_);_(@_)6+1_(* #,##0.00_);_(* \(#,##0.00\);_(* "-"??_);_(@_) #,##0\ "kr.";\-#,##0\ "kr."% #,##0\ "kr.";[Red]\-#,##0\ "kr."&!#,##0.00\ "kr.";\-#,##0.00\ "kr."+&#,##0.00\ "kr.";[Red]\-#,##0.00\ "kr."A<_-* #,##0\ "kr."_-;\-* #,##0\ "kr."_-;_-* "-"\ "kr."_-;_-@_-,'_-* #,##0_-;\-* #,##0_-;_-* "-"_-;_-@_-ID_-* #,##0.00\ "kr."_-;\-* #,##0.00\ "kr."_-;_-* "-"??\ "kr."_-;_-@_-4/_-* #,##0.00_-;\-* #,##0.00_-;_-* "-"??_-;_-@_-                                                                       ff         P@ @  P@ @  @       `@ @            a@ >   H1  H5  H$  H<   ||Ck}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-} _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-}  _-;_-* "}-} _-;_-* "}-} _-;_-* "}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef?\ "kr."}A} _-;_-* "ef ?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L?\ "kr."}A} _-;_-* "L ?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A} _-;_-* "23?\ "kr."}A}  _-;_-* "23?\ "kr."}A}! _-;_-* "23 ?\ "kr."}A}" _-;_-* "?\ "kr."}A}# _-;_-* "?\ "kr."}A}$ _-;_-* "?\ "kr."}A}% _-;_-* "?\ "kr."}A}& _-;_-* "?\ "kr."}A}' _-;_-* " ?\ "kr."}A}( _-;_-* "?\ "kr."}}) }_-;_-* "?\ "kr."   }}* _-;_-* "?\ "kr."??? ??? ??? ???}-}+ _-;_-* "}-}, _-;_-* "}-}- _-;_-* "}-}. _-;_-* "}-}/ _-;_-* "}A}0 a_-;_-* "?\ "kr."}A}1 _-;_-* "?\ "kr."}A}2 _-;_-* "??\ "kr."}A}3 _-;_-* "23?\ "kr."}-}4 _-;_-* "}}5 ??v_-;_-* "̙?\ "kr."   }A}6 }_-;_-* "?\ "kr."}A}7 W_-;_-* "?\ "kr."}}8 _-;_-* "?\ "kr."   }}9 ???_-;_-* "?\ "kr."??? ??? ??? ???}-}: _-;_-* "}-}; _-;_-* "}U}< _-;_-* "?\ "kr." }-}= _-;_-* "}A}> _-;_-* "?\ "kr."}A}? _-;_-* "?\ "kr."}A}@ _-;_-* "p0?\ "kr."}A}A _-;_-* "?\ "kr."}-}B _-;_-* " 20% - Accent1M 20% - Accent1 ef % 20% - Accent2M" 20% - Accent2 ef % 20% - Accent3M& 20% - Accent3 ef % 20% - Accent4M* 20% - Accent4 ef % 20% - Accent5M. 20% - Accent5 ef % 20% - Accent6M2 20% - Accent6  ef % 40% - Accent1M 40% - Accent1 L % 40% - Accent2M# 40% - Accent2 L˭ % 40% - Accent3M' 40% - Accent3 L % 40% - Accent4M+ 40% - Accent4 L % 40% - Accent5M/ 40% - Accent5 L % 40% - Accent6M3 40% - Accent6  L % 60% - Accent1M 60% - Accent1 23 % 60% - Accent2M$ 60% - Accent2 23 % 60% - Accent3M( 60% - Accent3 23 % 60% - Accent4M, 60% - Accent4 23f % 60% - Accent5M0 60% - Accent5 23 %! 60% - Accent6M4 60% - Accent6  23Ў % "Accent1AAccent1 Dr % #Accent2A!Accent2 }1 % $Accent3A%Accent3  % %Accent4A)Accent4  % &Accent5A-Accent5 [ % 'Accent6A1Accent6  pG %(Bad9Bad  %) Calculation Calculation  }% * Check Cell Check Cell  %????????? ???+ Comma,( Comma [0]-&Currency.. Currency [0]/Explanatory TextG5Explanatory Text % 0Good;Good  a%1 Heading 1G Heading 1 DTj%Dr2 Heading 2G Heading 2 DTj%?3 Heading 3G Heading 3 DTj%234 Heading 49 Heading 4 DTj% 5InputuInput ̙ ??v% 6 Linked CellK Linked Cell }% 7NeutralANeutral  W%3Normal % 8Noteb Note   9OutputwOutput  ???%????????? ???:$Percent ;Title1Title DTj% <TotalMTotal %DrDr= Warning Text? Warning Text %XTableStyleMedium2PivotStyleLight16`0 group 3 up%%Ogroup_3_overlap_down_pathways5 CNijmegen breakage syndromeBloom syndromeidnum#Surfactant metabolism.R-HSA-5683826/Noncanonical activation of NOTCH3.R-HSA-9017802#2-LTR circle formation.R-HSA-164843!Recycling of eIF2:GDP.R-HSA-727318Regulation of lipid metabolism by PPARalpha.R-HSA-400206,Regulation of insulin secretion.R-HSA-4223560Regulation of beta-cell development.R-HSA-186712;Regulation of TP53 Expression and Degradation.R-HSA-6806003,Regulation of TP53 Degradation.R-HSA-6804757)Regulation of TP53 Activity.R-HSA-5633007ARegulation of TP53 Activity through Phosphorylation.R-HSA-6804756<Regulation of PLK1 Activity at G2-M Transition.R-HSA-2565942HRegulation of FOXO transcriptional activity by acetylation.R-HSA-9617629KRegulation of APC-C activators between G1-S and early anaphase.R-HSA-176408/Reduction of cytosolic Ca++ levels.R-HSA-418359$Recycling pathway of L1.R-HSA-437239ERecruitment of mitotic centrosome proteins and complexes.R-HSA-380270-Regulation of mitotic cell cycle.R-HSA-4532767Recruitment of NuMA to mitotic centrosomes.R-HSA-380320wRecruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.R-HSA-5693565@RUNX3 Regulates Immune Response and Cell Migration.R-HSA-89492754RUNX2 regulates chondrocyte maturation.R-HSA-8941284VRUNX1 regulates transcription of genes involved in interleukin signaling.R-HSA-8939247NRUNX1 regulates transcription of genes involved in WNT signaling.R-HSA-8939256NRUNX1 regulates transcription of genes involved in BCR signaling.R-HSA-8939245`RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.R-HSA-8939243,RORA activates gene expression.R-HSA-1368082LRNA Polymerase III Transcription Initiation From Type 2 Promoter.R-HSA-760667RNA Polymerase II Transcription Termination.R-HSA-738566RNA Polymerase II Transcription Elongation.R-HSA-759557RNA Polymerase II Pre-transcription Events.R-HSA-674695.RMTs methylate histone arginines.R-HSA-3214858FRegulation of localization of FOXO transcription factors.R-HSA-96143998Regulation of ornithine decarboxylase (ODC).R-HSA-350562*RHO GTPases Activate Formins.R-HSA-56632206Release of Hh-Np from the secreting cell.R-HSA-5362798-Scavenging by Class F Receptors.R-HSA-3000484SUMOylation.R-HSA-29908466SUMOylation of ubiquitinylation proteins.R-HSA-32321424SUMOylation of transcription cofactors.R-HSA-38993004SUMOylation of intracellular receptors.R-HSA-40902945SUMOylation of immune response proteins.R-HSA-47555105SUMOylation of DNA replication proteins.R-HSA-4615885DSUMOylation of DNA damage response and repair proteins.R-HSA-3108214=SUMO is transferred from E1 to E2 (UBE2I, UBC9).R-HSA-30656782SUMO is conjugated to E1 (UBA2:SAE1).R-HSA-30656767SUMO E3 ligases SUMOylate target proteins.R-HSA-31082324SMAC, XIAP-regulated apoptotic response.R-HSA-111469ISMAC(DIABLO)-mediated dissociation of IAP:caspase complexes .R-HSA-111464)SMAC (DIABLO) binds to IAPs .R-HSA-1114631SLC-mediated transmembrane transport.R-HSA-425407=SLBP independent Processing of Histone Pre-mRNAs.R-HSA-111367PSLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.R-HSA-775886SCF(Skp2)-mediated degradation of p27-p21.R-HSA-187577<Role of second messengers in netrin-1 signaling.R-HSA-4188903Role of phospholipids in phagocytosis.R-HSA-2029485;Role of LAT2-NTAL-LAB on calcium mobilization.R-HSA-2730905Rho GTPase cycle.R-HSA-1948403Rev-mediated nuclear export of HIV RNA.R-HSA-165054-Response of Mtb to phagocytosis.R-HSA-9637690QResolution of AP sites via the single-nucleotide replacement pathway.R-HSA-110381Reproduction.R-HSA-1474165?Release of apoptotic factors from the mitochondria.R-HSA-1114571RHO GTPases Activate NADPH Oxidases.R-HSA-5668599RET signaling.R-HSA-8853659!Signal amplification.R-HSA-392518"Nicotinate metabolism.R-HSA-196807'Organic anion transporters.R-HSA-428643'Orc1 removal from chromatin.R-HSA-68949Opioid Signalling.R-HSA-111885)Oncogene Induced Senescence.R-HSA-25595858Oligomerization of connexins into connexons.R-HSA-190704#Nucleobase catabolism.R-HSA-8956319%Nucleobase biosynthesis.R-HSA-8956320*Nuclear import of Rev protein.R-HSA-1807464Nuclear Pore Complex (NPC) Disassembly.R-HSA-3301854(Nuclear Envelope Breakdown.R-HSA-2980766.Nonhomologous End-Joining (NHEJ).R-HSA-56935714Non-integrin membrane-ECM interactions.R-HSA-30001716Nitric oxide stimulates guanylate cyclase.R-HSA-392154'Neurotransmitter clearance.R-HSA-112311.PAOs oxidise polyamines to amines.R-HSA-1413340Neurotoxicity of clostridium toxins.R-HSA-168799.Netrin mediated repulsion signals.R-HSA-418886XNegative regulation of TCF-dependent signaling by DVL-interacting proteins.R-HSA-53685984Negative regulation of FGFR4 signaling.R-HSA-56547334Negative regulation of FGFR3 signaling.R-HSA-56547324Negative regulation of FGFR2 signaling.R-HSA-56547274Negative regulation of FGFR1 signaling.R-HSA-5654726kNef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters.R-HSA-164938-Nef Mediated CD8 Down-regulation.R-HSA-182218Neddylation.R-HSA-89516642NS1 Mediated Effects on Host Pathways.R-HSA-168276JNR1H2 & NR1H3 regulate gene expression linked to lipogenesis.R-HSA-9029558INOTCH3 Activation and Transmission of Signal to the Nucleus.R-HSA-9013507%Organic cation transport.R-HSA-549127@PI and PC transport between ER and Golgi membranes.R-HSA-1483196RAF activation.R-HSA-5673000 Potassium Channels.R-HSA-1296071;Pyruvate metabolism and Citric Acid (TCA) cycle.R-HSA-71406<Purine ribonucleoside monophosphate biosynthesis.R-HSA-73817Purine catabolism.R-HSA-74259$Protein ubiquitination.R-HSA-8852135BProstacyclin signalling through prostacyclin receptor.R-HSA-392851!Processing of SMDT1.R-HSA-89496648Processing of DNA double-strand break ends.R-HSA-5693607;Processing of Capped Intron-Containing Pre-mRNA.R-HSA-72203/Processing and activation of SUMO.R-HSA-32150186Presynaptic function of Kainate receptors.R-HSA-500657&Pregnenolone biosynthesis.R-HSA-196108BPrefoldin mediated transfer of substrate to CCT-TriC.R-HSA-389957+Pre-NOTCH Processing in Golgi.R-HSA-19124208Post-translational protein phosphorylation.R-HSA-8957275!PI-3K cascade:FGFR4.R-HSA-5654720-Polo-like kinase mediated events.R-HSA-156711+Plasma lipoprotein remodeling.R-HSA-8963899)Phosphorylation of the APC-C.R-HSA-176412$Phosphorylation of Emi1.R-HSA-176417 Phospholipase C-mediated cascade5Phospholipase C-mediated cascade: FGFR1.R-HSA-5654219)Peroxisomal lipid metabolism.R-HSA-390918@Pausing and recovery of Tat-mediated HIV elongation.R-HSA-1672383Pausing and recovery of HIV elongation.R-HSA-167290@PTK6 Regulates Proteins Involved in RNA Processing.R-HSA-8849468"PTK6 Down-Regulation.R-HSA-8849472-PPARA activates gene expression.R-HSA-1989781;POLB-Dependent Long Patch Base Excision Repair.R-HSA-110362?Sealing of the nuclear envelope (NE) by ESCRT-III.R-HSA-9668328Signal attenuation.R-HSA-74749EADORA2B mediated anti-inflammatory cytokines production.R-HSA-9660821BTransport of Ribonucleoproteins into the Host Nucleus.R-HSA-1682710VEGFR2 mediated cell proliferation.R-HSA-5218921Urea cycle.R-HSA-706353Uptake and function of anthrax toxins.R-HSA-52108914Uptake and actions of bacterial toxins.R-HSA-5339562Unwinding of DNA.R-HSA-1769747Ubiquitin-dependent degradation of Cyclin D.R-HSA-75815UCH proteinases.R-HSA-5689603%Triglyceride metabolism.R-HSA-8979227$Triglyceride catabolism.R-HSA-163560:Transport of the SLBP independent Mature mRNA.R-HSA-1592278Transport of the SLBP Dependant Mature mRNA.R-HSA-159230(Transport of organic anions.R-HSA-879518PTransport of inorganic cations-anions and amino acids-oligopeptides.R-HSA-425393JTransport of Mature mRNAs Derived from Intronless Transcripts.R-HSA-1592341Vitamin B5 (pantothenate) metabolism.R-HSA-199220RTransport of Mature mRNA derived from an Intron-Containing Transcript.R-HSA-159236KTransport of Mature mRNA Derived from an Intronless Transcript.R-HSA-1592317Transport of Matur< e Transcript to Cytoplasm.R-HSA-722022Transferrin endocytosis and recycling.R-HSA-917977JTranscriptional regulation of white adipocyte differentiation.R-HSA-381340@Transcriptional activation of p53 responsive genes .R-HSA-69560DTranscriptional activation of mitochondrial biogenesis.R-HSA-21512011Transcriptional Regulation by VENTX.R-HSA-88538840Transcriptional Regulation by E2F6.R-HSA-8953750ETranscriptional activation of cell cycle inhibitor p21 .R-HSA-69895GTranscription-Coupled Nucleotide Excision Repair (TC-NER).R-HSA-6781827vTranscription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1.R-HSA-1362300RTranscription of E2F targets under negative control by DREAM complex.R-HSA-1362277IVasopressin regulates renal water homeostasis via Aquaporins.R-HSA-4320400Vpr-mediated nuclear import of PICs.R-HSA-1809109Toxicity of botulinum toxin type F (BoNT-F).R-HSA-5250981CS-DS degradation.R-HSA-2024101:Synthesis of IP2, IP, and Ins in the cytosol.R-HSA-1855183&Smooth Muscle Contraction.R-HSA-445355CSema4D induced cell migration and growth-cone collapse.R-HSA-416572+Sema4D in semaphorin signaling.R-HSA-400685(RHO GTPases Activate ROCKs.R-HSA-5627117Muscle contraction.R-HSA-397014'Metabolism of carbohydrates.R-HSA-71387+Inositol phosphate metabolism.R-HSA-1483249*Glycosaminoglycan metabolism.R-HSA-16303164Formation of editosomes by ADAR proteins.R-HSA-77042ECM proteoglycans.R-HSA-3000178+Dermatan sulfate biosynthesis.R-HSA-2022923.Chondroitin sulfate biosynthesis.R-HSA-2022870'C6 deamination of adenosine.R-HSA-751025WNT5A-dependent internalization of FZD4.R-HSA-5099900vRNP Assembly.R-HSA-1929052tRNA processing in the mitochondrion.R-HSA-6785470:tRNA modification in the nucleus and cytosol.R-HSA-6782315snRNP Assembly.R-HSA-1918592rRNA processing in the mitochondrion.R-HSA-8868766;p75NTR negatively regulates cell cycle via SC1.R-HSA-1936701p75 NTR receptor-mediated signalling.R-HSA-193704p38MAPK events.R-HSA-171007mRNA Splicing.R-HSA-72172)mRNA Splicing - Minor Pathway.R-HSA-72165)mRNA Splicing - Major Pathway.R-HSA-72163"mRNA 3'-end processing.R-HSA-72187Lalpha-linolenic (omega3) and linoleic (omega6) acid metabolism.R-HSA-20461046Transcription from mitochondrial promoters.R-HSA-759449Toxicity of botulinum toxin type E (BoNT-E).R-HSA-5250992)Signaling by EGFR in Cancer.R-HSA-1643713!Signaling by NOTCH1.R-HSA-1980143<Switching of origins to a post-replicative state.R-HSA-690522Suppression of phagosomal maturation.R-HSA-9637687*Sulfide oxidation to sulfate.R-HSA-1614517.Spry regulation of FGF signaling.R-HSA-1295596&Sodium-Calcium exchangers.R-HSA-425561 Signalling to STAT3.R-HSA-1987453Signaling by the B Cell Receptor (BCR).R-HSA-983705Signaling by WNT.R-HSA-195721(Signaling by Retinoic Acid.R-HSA-53625174Signaling by Receptor Tyrosine Kinases.R-HSA-9006934Signaling by PTK6.R-HSA-8848021Signaling by PDGF.R-HSA-1867978Signaling by Non-Receptor Tyrosine Kinases.R-HSA-9006927Signaling by NOTCH1 t(7GSynthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).R-HSA-2142816DSignaling by Ligand-Responsive EGFR Variants in Cancer.R-HSA-5637815)Signaling by Insulin receptor.R-HSA-74752 Signaling by FGFR3.R-HSA-56547418Signaling by FGFR3 point mutants in cancer.R-HSA-8853338+Signaling by FGFR3 in disease.R-HSA-5655332(Signaling by FGFR2 IIIa TM.R-HSA-8851708 Signaling by FGFR1.R-HSA-5654736Signaling by FGFR.R-HSA-190236*Signaling by FGFR in disease.R-HSA-1226099 Signaling by ERBB2.R-HSA-1227986*Signaling by ERBB2 in Cancer.R-HSA-12279900Signaling by ERBB2 TMD-JMD mutants.R-HSA-9665686-Signaling by EGFRvIII in Cancer.R-HSA-5637812#Syndecan interactions.R-HSA-3000170?Synthesis of 12-eicosatetraenoic acid derivatives.R-HSA-21427129Toxicity of botulinum toxin type D (BoNT-D).R-HSA-5250955>TP53 Regulates Transcription of Cell Cycle Genes.R-HSA-67913129Toxicity of botulinum toxin type A (BoNT-A).R-HSA-52509687Thromboxane signalling through TP receptor.R-HSA-428930NThrombin signalling through proteinase activated receptors (PARs).R-HSA-456926JThe role of Nef in HIV-1 replication and disease pathogenesis.R-HSA-164952GThe role of GTSE1 in G2-M progression after G2 checkpoint.R-HSA-8852276LThe citric acid (TCA) cycle and respiratory electron transport.R-HSA-1428517TTetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation.R-HSA-1474151-Telomere Extension By Telomerase.R-HSA-1713193Telomere C-strand synthesis initiation.R-HSA-174430<Tat-mediated HIV elongation arrest and recovery.R-HSA-167243TRAIL signaling.R-HSA-75158DTRAF6 mediated IRF7 activation in TLR7-8 or 9 signaling.R-HSA-975110TTP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest.R-HSA-6804114/TNFR2 non-canonical NF-kB pathway.R-HSA-5668541?Synthesis of 15-eicosatetraenoic acid derivatives.R-HSA-2142770WTGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).R-HSA-21737919TGF-beta receptor signaling activates SMADs.R-HSA-2173789jTFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation.R-HSA-8869496OTFAP2 (AP-2) family regulates transcription of cell cycle factors.R-HSA-8866911.TET1,2,3 and TDG demethylate DNA.R-HSA-52210307TCF dependent signaling in response to WNT.R-HSA-201681VSynthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).R-HSA-381771QSynthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.R-HSA-193368GSynthesis of active ubiquitin: roles of E1 and E2 enzymes.R-HSA-8866652DSynthesis of Prostaglandins (PG) and Thromboxanes (TX).R-HSA-2162123Synthesis of PS.R-HSA-1483101Synthesis of PG.R-HSA-14831483Synthesis of 5-eicosatetraenoic acids.R-HSA-2142688,NOSIP mediated eNOS trafficking.R-HSA-2037540NIK-->noncanonical NF-kB signaling.R-HSA-5676590ANEP-NS2 Interacts with the Cellular Export Machinery.R-HSA-168333Cell Cycle, Mitotic.R-HSA-69278;Constitutive Signaling by Overexpressed ERBB2.R-HSA-9634285$Constitutive Signaling by NOTCH1 t(7NConstitutive Signaling by Ligand-Responsive EGFR Cancer Variants.R-HSA-12363820Constitutive Signaling by EGFRvIII.R-HSA-5637810*Collagen chain trimerization.R-HSA-8948216$Coenzyme A biosynthesis.R-HSA-196783+Clathrin-mediated endocytosis.R-HSA-8856828CClass I MHC mediated antigen processing & presentation.R-HSA-983169)Citric acid cycle (TCA cycle).R-HSA-714036Cholesterol biosynthesis via lathosterol.R-HSA-68070627ChREBP activates metabolic gene expression.R-HSA-163765"Centrosome maturation.R-HSA-380287Cell Cycle.R-HSA-1640170"Cell Cycle Checkpoints.R-HSA-69620PCooperation of PDCL (PhLP1) and TRiC-CCT in G-protein beta folding.R-HSA-6814122ACdc20:Phospho-APC-C mediated degradation of Cyclin A.R-HSA-174184Carnitine synthesis.R-HSA-71262!Carnitine metabolism.R-HSA-200425ACargo recognition for clathrin-mediated endocytosis.R-HSA-8856825COX reactions.R-HSA-140180)CLEC7A (Dectin-1) signaling.R-HSA-5607764=CDT1 association with the CDC6:ORC:origin complex.R-HSA-68827<CDK-mediated phosphorylation and removal of Cdc6.R-HSA-690178CDC6 association with the ORC:origin complex.R-HSA-68689,C-type lectin receptors (CLRs).R-HSA-5621481,Breakdown of the nuclear lamina.R-HSA-352238,Biotin transport and metabolism.R-HSA-196780fBiosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR).R-HSA-9026766GConversion from APC-C:Cdc20 to APC-C:Cdh1 in late anaphase.R-HSA-176407CCyclin A-B1-B2 associated events during G2-M transition.R-HSA-69273.Biosynthesis of EPA-derived SPMs.R-HSA-9018679<Dectin-1 mediated noncanonical NF-kB signaling.R-HSA-5607761HE2F-enabled inhibition of pre-replication complex formation.R-HSA-1135077E2F mediated regulation of DNA replication.R-HSA-113510%Dual incision in TC-NER.R-HSA-67821359Drug-mediated inhibition of ERBB2 signaling.R-HSA-96522825Downstream signaling of activated FGFR3.R-HSA-56547085Downstream signaling of activated FGFR1.R-HSA-5654687+Downstream signal transduction.R-HSA-186763FDownregulat< ion of SMAD2-3:SMAD4 transcriptional activity.R-HSA-2173795Disease.R-HSA-1643685Deubiquitination.R-HSA-56884266Degradation of cysteine and homocysteine.R-HSA-1614558CDegradation of beta-catenin by the destruction complex.R-HSA-195253Dectin-2 family.R-HSA-5621480"Deadenylation of mRNA.R-HSA-429947<Cyclin A:Cdk2-associated events at S phase entry.R-HSA-69656FDeactivation of the beta-catenin transactivating complex.R-HSA-3769402DSCAM interactions.R-HSA-376172&DNA replication initiation.R-HSA-68952*DNA Replication Pre-Initiation.R-HSA-69002DNA Repair.R-HSA-73894,DNA Double-Strand Break Repair.R-HSA-5693532.DNA Double Strand Break Response.R-HSA-5693606;DNA Damage-Telomere Stress Induced Senescence.R-HSA-2559586.DNA Damage Recognition in GG-NER.R-HSA-5696394\DEx-H-box helicases activate type I IFN and inflammatory cytokines production .R-HSA-3134963DAP12 signaling.R-HSA-24244915Cytosolic sulfonation of small molecules.R-HSA-156584,Cyclin D associated events in G1.R-HSA-69231BBiosynthesis of aspirin-triggered D-series resolvins.R-HSA-90202656Biosynthesis of E-series 18(S)-resolvins.R-HSA-90188966EGFR interacts with phospholipase C-gamma.R-HSA-212718JAbortive elongation of HIV-1 transcript in the absence of Tat.R-HSA-167242HActivation of caspases through apoptosome-mediated cleavage.R-HSA-111459bActivation of anterior HOX genes in hindbrain development during early embryogenesis.R-HSA-5617472Activation of SMO.R-HSA-5635838<Activation of HOX genes during differentiation.R-HSA-5619507*Activation of GABAB receptors.R-HSA-991365>Activation of G protein gated Potassium channels.R-HSA-1296041@Activation of BMF and translocation to mitochondria.R-HSA-139910,Activation of BH3-only proteins.R-HSA-114452AActivation of BAD and translocation to mitochondria .R-HSA-111447@Activation of ATR in response to replication stress.R-HSA-176187YActivation of APC-C and APC-C:Cdc20 mediated degradation of mitotic proteins.R-HSA-1768145Activation of AMPK downstream of NMDARs.R-HSA-9619483>Activated NOTCH1 Transmits Signal to the Nucleus.R-HSA-21229488AUF1 (hnRNP D0) binds and destabilizes mRNA.R-HSA-450408CActivation of kainate receptors upon glutamate binding.R-HSA-4513263ATF6 (ATF6-alpha) activates chaperones.R-HSA-381033tAPC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint.R-HSA-1794194APC-Cdc20 mediated degradation of Nek2A.R-HSA-179409uAPC-C:Cdh1 mediated degradation of Cdc20 and other APC-C:Cdh1 targeted proteins in late mitosis-early G1.R-HSA-174178AAPC-C:Cdc20 mediated degradation of mitotic proteins.R-HSA-1764098APC-C:Cdc20 mediated degradation of Securin.R-HSA-1741549APC-C:Cdc20 mediated degradation of Cyclin B.R-HSA-174048>APC-C-mediated degradation of cell cycle proteins.R-HSA-174143:ALKBH3 mediated reversal of alkylation damage.R-HSA-1121260AKT-mediated inactivation of FOXO1A.R-HSA-2111636AKT phosphorylates targets in the nucleus.R-HSA-1986937ADP signalling through P2Y purinoceptor 12.R-HSA-3921706ADP signalling through P2Y purinoceptor 1.R-HSA-418592<Activation of gene expression by SREBF (SREBP).R-HSA-24261685Activation of the pre-replicative complex.R-HSA-689626Biosynthesis of E-series 18(R)-resolvins.R-HSA-9023661)Arachidonic acid metabolism.R-HSA-2142753<Biosynthesis of DHA-derived sulfido conjugates.R-HSA-9026395.Biosynthesis of DHA-derived SPMs.R-HSA-90186770Biosynthesis of D-series resolvins.R-HSA-9018676,Binding and entry of HIV virion.R-HSA-173107%Bicarbonate transporters.R-HSA-425381-Beta-oxidation of pristanoyl-CoA.R-HSA-3898879Autointegration results in viral DNA circles.R-HSA-1775392Autodegradation of Cdh1 by Cdh1:APC-C.R-HSA-174084MAssociation of TriC-CCT with target proteins during biosynthesis.R-HSA-3904713Assembly of the pre-replicative complex.R-HSA-68867DAssembly of the ORC complex at the origin of replication.R-HSA-68616JAssembly of collagen fibrils and other multimeric structures.R-HSA-2022090>Assembly of active LPL and LIPC lipase complexes.R-HSA-8963889)Aquaporin-mediated transport.R-HSA-445717)Acyl chain remodeling of CL.R-HSA-1482798/Apoptotic factor-mediated response.R-HSA-111471%Apoptotic execution phase.R-HSA-751530Apoptosis induced DNA fragmentation.R-HSA-1403429Antiviral mechanism by IFN-stimulated genes.R-HSA-1169410HAntigen processing: Ubiquitination & Proteasome degradation.R-HSA-983168_Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.R-HSA-983695"Androgen biosynthesis.R-HSA-193048)Amino acids regulate mTORC1.R-HSA-9639288$Amine Oxidase reactions.R-HSA-140179Aggrephagy.R-HSA-9646399@Adrenaline,noradrenaline inhibits insulin secretion.R-HSA-4000421Adenylate cyclase inhibitory pathway.R-HSA-1706701Adenylate cyclase activating pathway.R-HSA-170660?E3 ubiquitin ligases ubiquitinate target proteins.R-HSA-8866654*Early Phase of HIV Life Cycle.R-HSA-162594&Mitotic Spindle Checkpoint.R-HSA-69618<Interactions of Tat with host cellular proteins.R-HSA-176034Lysine catabolism.R-HSA-71064+Linoleic acid (LA) metabolism.R-HSA-2046105*Ligand-receptor interactions.R-HSA-56326815KSRP (KHSRP) binds and destabilizes mRNA.R-HSA-450604&Iron uptake and transport.R-HSA-917937-Inwardly rectifying K+ channels.R-HSA-1296065#Invadopodia formation.R-HSA-8941237,Intrinsic Pathway for Apoptosis.R-HSA-109606,Intestinal infectious diseases.R-HSA-8942233%Interleukin-2 signaling.R-HSA-9020558*Interconversion of polyamines.R-HSA-351200@Interconversion of nucleotide di- and triphosphates.R-HSA-499943<Interactions of Vpr with host cellular proteins.R-HSA-176033<Interactions of Rev with host cellular proteins.R-HSA-1772438MAP3K8 (TPL2)-dependent MAPK1-3 activation.R-HSA-5684264;Integration of viral DNA into host genomic DNA.R-HSA-175567$Integration of provirus.R-HSA-162592-Integration of energy metabolism.R-HSA-163685/Insulin receptor signalling cascade.R-HSA-74751&Insulin receptor recycling.R-HSA-77387Insulin processing.R-HSA-264876Inhibition of the proteolytic activity of APC-C required for the onset of anaphase by mitotic spindle checkpoint components.R-HSA-141405LInhibition of replication initiation of damaged DNA by RB1-E2F1.R-HSA-1135013Inhibition of nitric oxide production.R-HSA-9636249AInhibition of Host mRNA Processing and RNA Silencing.R-HSA-168315PInhibition of voltage gated Ca2+ channels via Gbeta-gamma subunits.R-HSA-997272>Influenza Viral RNA Transcription and Replication.R-HSA-168273 Influenza Infection.R-HSA-168255(Lysosome Vesicle Biogenesis.R-HSA-4327203MASTL Facilitates Mitotic Progression.R-HSA-2465910<Incretin synthesis, secretion, and inactivation.R-HSA-400508%Miscellaneous substrates.R-HSA-211958#Mitotic G2-G2-M phases.R-HSA-4532741Mitotic G1 phase and G1-S transition.R-HSA-453279'Mitochondrial translation.R-HSA-53682873Mitochondrial translation termination.R-HSA-54192762Mitochondrial translation initiation.R-HSA-53682862Mitochondrial translation elongation.R-HSA-5389840*Mitochondrial protein import.R-HSA-12680201Mitochondrial calcium ion transport.R-HSA-8949215&Mitochondrial biogenesis.R-HSA-1592230EMismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha).R-HSA-5358565DMismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta).R-HSA-5358606Mismatch Repair.R-HSA-53585088Miscellaneous transport and binding events.R-HSA-5223345+Metabolism of steroid hormones.R-HSA-196071=MECP2 regulates neuronal receptors and channels.R-HSA-9022699%Metabolism of polyamines.R-HSA-351202%Metabolism of nucleotides.R-HSA-15869)Metabolism of non-coding RNA.R-HSA-194441@Metabolism of ingested H2SeO4 and H2SeO3 into H2Se.R-HSA-2408550%Metabolism of cofactors.R-HSA-8978934Metabolism of RNA.R-HSA-8953854"Meiotic recombination.R-HSA-912446Meiosis.R-HSA-1500620$MET receptor recycling.R-HSA-8875656!MET activates STAT3.R-HSA-8875791"MET activates PTPN11.R-HSA-8865999?MECP2 regulates transcription of neuronal ligands.R-HSA-9022702OMECP2 regulates transcription of genes involved in GABA signaling.R-HSA-9022927< Infectious disease.R-HSA-5663205+Inactivation of CDC42 and RAC1.R-HSA-4285439Electron transport from NADPH to Ferredoxin.R-HSA-2395516*G alpha (z) signalling events.R-HSA-418597G2-M Transition.R-HSA-69275&G2-M DNA damage checkpoint.R-HSA-69473G2-M Checkpoints.R-HSA-69481G2 Phase.R-HSA-68911'G1-S-Specific Transcription.R-HSA-69205G1-S Transition.R-HSA-69206G1 Phase.R-HSA-69236G0 and Early G1.R-HSA-1538133!G-protein activation.R-HSA-2020400G protein gated Potassium channels.R-HSA-12960595G beta:gamma signalling through PLC beta.R-HSA-4182173G beta:gamma signalling through CDC42.R-HSA-89646161G beta:gamma signalling through BTK.R-HSA-8964315.G alpha (12-13) signalling events.R-HSA-416482%GABA receptor activation.R-HSA-9774435Formation of selenosugars for excretion.R-HSA-2408499LFormation of Senescence-Associated Heterochromatin Foci (SAHF).R-HSA-25595848Formation of RNA Pol II elongation complex .R-HSA-112382'Fatty acyl-CoA biosynthesis.R-HSA-75105Fatty acids.R-HSA-211935#Fatty acid metabolism.R-HSA-89788681FGFR2b ligand binding and activation.R-HSA-190377FCGR activation.R-HSA-2029481/Extracellular matrix organization.R-HSA-1474244<Export of Viral Ribonucleoproteins from Nucleus.R-HSA-168274CErythropoietin activates Phospholipase C gamma (PLCG).R-HSA-9027277=Energy dependent regulation of mTOR by LKB1-AMPK.R-HSA-380972EEndosomal Sorting Complex Required For Transport (ESCRT).R-HSA-917729'GABA B receptor activation.R-HSA-977444>GABA synthesis, release, reuptake and degradation.R-HSA-888590MInactivation of APC-C via direct inhibition of the APC-C complex.R-HSA-141430HIV Infection.R-HSA-162906Immune System.R-HSA-168256'ISG15 antiviral mechanism.R-HSA-1169408$IRS-mediated signalling.R-HSA-112399IRS activation.R-HSA-747133IRF3-mediated induction of type I IFN.R-HSA-3270619'IRAK1 recruits IKK complex.R-HSA-937039DIRAK1 recruits IKK complex upon TLR7-8 or 9 stimulation.R-HSA-9751441Hypusine synthesis from eIF5A-lysine.R-HSA-204626Hydrolysis of LPC.R-HSA-1483115-Host Interactions of HIV factors.R-HSA-162909-Hormone ligand-binding receptors.R-HSA-375281 Histidine catabolism.R-HSA-70921/HIV elongation arrest and recovery.R-HSA-167287)HDR through MMEJ (alt-NHEJ).R-HSA-5685939YGLI proteins bind promoters of Hh responsive genes to promote transcription.R-HSA-5635851HCMV Late Events.R-HSA-9610379HCMV Early Events.R-HSA-9609690.Growth hormone receptor signaling.R-HSA-982772:Glyoxylate metabolism and glycine degradation.R-HSA-389661!Glycine degradation.R-HSA-6783984,Glycerophospholipid catabolism.R-HSA-6814848.Glycerophospholipid biosynthesis.R-HSA-1483206Glucose metabolism.R-HSA-70326Gluconeogenesis.R-HSA-702637Glucagon signaling in metabolic regulation.R-HSA-1633595Generation of second messenger molecules.R-HSA-202433%Gap junction trafficking.R-HSA-190828"Gap junction assembly.R-HSA-190861+mRNA Editing: A to I Conversion.R-HSA-750646AKT phosphorylates targets in the cytosol.R-HSA-198323-RNA Polymerase II Promoter Escape.R-HSA-73776:Norepinephrine Neurotransmitter Release Cycle.R-HSA-181430$OAS antiviral response.R-HSA-89837112Organelle biogenesis and maintenance.R-HSA-1852241(Other interleukin signaling.R-HSA-449836PD-1 signaling.R-HSA-389948,PI3K events in ERBB2 signaling.R-HSA-1963642+PINK1-PRKN Mediated Mitophagy.R-HSA-5205685*PIP3 activates AKT signaling.R-HSA-12576042PKA activation in glucagon signalling.R-HSA-164378PKA activation.R-HSA-1636151PKA-mediated phosphorylation of CREB.R-HSA-111931PTEN Regulation.R-HSA-6807070DPTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.R-HSA-8849471(Peroxisomal protein import.R-HSA-90332419Post-transcriptional silencing by small RNAs.R-HSA-426496"Protein localization.R-HSA-96095073RAB GEFs exchange GTP for GDP on RABs.R-HSA-8876198XRNA Pol II CTD phosphorylation and interaction with CE during HIV infection.R-HSA-167160BRNA Pol II CTD phosphorylation and interaction with CE.R-HSA-77075(Neurodegenerative Diseases.R-HSA-8863678Netrin-1 signaling.R-HSA-3737529Negative regulators of DDX58-IFIH1 signaling.R-HSA-936440%MET Receptor Activation.R-HSA-6806942'Interleukin-35 Signalling.R-HSA-89847228Interleukin-4 and Interleukin-13 signaling.R-HSA-6785807:Intracellular signaling by second messengers.R-HSA-9006925&Intraflagellar transport.R-HSA-5620924:Listeria monocytogenes entry into host cells.R-HSA-8876384LLocalization of the PINCH-ILK-PARVIN complex to focal adhesions.R-HSA-446343AMAPK targets- Nuclear events mediated by MAP kinases.R-HSA-450282#MAPK6-MAPK4 signaling.R-HSA-5687128(MET promotes cell motility.R-HSA-88758781Negative regulation of MET activity.R-HSA-6807004;Metabolism of Angiotensinogen to Angiotensins.R-HSA-2022377*Metallothioneins bind metals.R-HSA-5661231(Methionine salvage pathway.R-HSA-1237112Methylation.R-HSA-156581Mitophagy.R-HSA-5205647)Mitotic Telophase-Cytokinesis.R-HSA-68884Myogenesis.R-HSA-525793INOTCH2 Activation and Transmission of Signal to the Nucleus.R-HSA-29790962RNA Polymerase II HIV Promoter Escape.R-HSA-167162MRNA Polymerase II Transcription Initiation And Promoter Clearance.R-HSA-76042'Interferon gamma signaling.R-HSA-8773006RNA Polymerase II Transcription Initiation.R-HSA-75953XSignaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants.R-HSA-9673767"Signaling by SCF-KIT.R-HSA-1433557.Signaling by TGFB family members.R-HSA-9006936Signaling by VEGF.R-HSA-194138(Signaling by WNT in cancer.R-HSA-4791275/Sphingolipid de novo biosynthesis.R-HSA-1660661$Sphingolipid metabolism.R-HSA-4281576Synthesis of PIPs at the plasma membrane.R-HSA-1660499TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.R-HSA-6803205#The NLRP3 inflammasome.R-HSA-8444561Transcriptional regulation by RUNX2.R-HSA-8878166_Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template.R-HSA-110313AVEGF binds to VEGFR leading to receptor dimerization.R-HSA-195399.VEGF ligand-receptor interactions.R-HSA-194313"VEGFA-VEGFR2 Pathway.R-HSA-4420097MWNT ligand secretion is abrogated by the PORCN inhibitor LGK974.R-HSA-5340573cGMP effects.R-HSA-418457mRNA Capping.R-HSA-720863mRNA decay by 5' to 3' exoribonuclease.R-HSA-430039>Signaling by PDGFRA extracellular domain mutants.R-HSA-9673770+Signaling by PDGFR in disease.R-HSA-9671555 Signaling by Hippo.R-HSA-2028269)Receptor Mediated Mitophagy.R-HSA-8934903ORNA Polymerase II Transcription Pre-Initiation And Promoter Opening.R-HSA-737797RNA polymerase II transcribes snRNA genes.R-HSA-6807505YRUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs).R-HSA-8877330PRUNX2 regulates genes involved in differentiation of myeloid cells.R-HSA-89413339RUNX3 regulates BCL2L11 (BIM) transcription.R-HSA-8952158+RUNX3 regulates WNT signaling.R-HSA-8951430+Rab regulation of trafficking.R-HSA-9007101Rap1 signalling.R-HSA-392517'Reelin signalling pathway.R-HSA-8866376DSMAD2-SMAD3:SMAD4 heterotrimer regulates transcription.R-HSA-2173796=Regulation of HSF1-mediated heat shock response.R-HSA-33714531Regulation of PTEN mRNA translation.R-HSA-89437237Regulation of PTEN stability and activity.R-HSA-89487519Regulation of RUNX1 Expression and Activity.R-HSA-8934593+Regulation of TP53 Expression.R-HSA-6804754PRegulation of mRNA stability by proteins that bind AU-rich elements.R-HSA-450531NSEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.R-HSA-3999553SHC-related events triggered by IGF1R.R-HSA-2428933&Interleukin-10 signaling.R-HSA-6783783TTP53 Regulates Transcription of Genes Involved in Cytochrome C Release.R-HSA-6803204,Interferon alpha-beta signaling.R-HSA-909733DNA Damage Bypass.R-HSA-73893<FGFR1c and Klotho ligand binding and activation.R-HSA-190374.Extra-nuclear estrogen signaling.R-HSA-90093919Acetylcholine Neurotransmitter Release Cycle.R-HSA-264642TEstrogen-dependent nuclear events downstream of ESR-membrane signaling.R-HSA-9634638< (Endosomal-Vacuolar pathway.R-HSA-1236977AActivation of NOXA and translocation to mitochondria.R-HSA-111448Activation of RAC1.R-HSA-428540-EPHB-mediated forward signaling.R-HSA-3928662 EGFR downregulation.R-HSA-182971CActivation of the AP-1 family of transcription factors.R-HSA-450341WAntigen Presentation: Folding, assembly and peptide loading of class I MHC.R-HSA-983170iDeregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.R-HSA-88628033Degradation of GLI1 by the proteasome.R-HSA-56107801Cytokine Signaling in Immune system.R-HSA-1280215QFormyl peptide receptors bind formyl peptides and many other ligands.R-HSA-444473JCompeting endogenous RNAs (ceRNAs) regulate PTEN translation.R-HSA-8948700,Cohesin Loading onto Chromatin.R-HSA-2470946Cilium Assembly.R-HSA-5617833%Cell-Cell communication.R-HSA-1500931FAssembly and cell surface presentation of NMDA receptors.R-HSA-9609736;Cargo trafficking to the periciliary membrane.R-HSA-5620920YBH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.R-HSA-111453;COPI-dependent Golgi-to-ER retrograde traffic.R-HSA-6811434CBMAL1:CLOCK,NPAS2 activates circadian gene expression.R-HSA-1368108"Biological oxidations.R-HSA-211859JButyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.R-HSA-450385(CD28 dependent Vav1 pathway.R-HSA-389359'CD209 (DC-SIGN) signaling.R-HSA-5621575=FOXO-mediated transcription of cell death genes.R-HSA-96146578Establishment of Sister Chromatid Cohesion.R-HSA-2468052JInlB-mediated entry of Listeria monocytogenes into host cell.R-HSA-88753605Glutamate Neurotransmitter Release Cycle.R-HSA-210500!HS-GAG biosynthesis.R-HSA-2022928Inhibition of PKR.R-HSA-169131!Interferon Signaling.R-HSA-913531-Initial triggering of complement.R-HSA-166663YInsertion of tail-anchored proteins into the endoplasmic reticulum membrane.R-HSA-9609523)HIV Transcription Initiation.R-HSA-167161'PTK6 Regulates Cell Cycle.R-HSA-8849470/PTK6 promotes HIF1A stabilization.R-HSA-88575389Regulation of RUNX2 expression and activity.R-HSA-8939902'Regulation of RAS by GAPs.R-HSA-5658442aRUNX1 regulates transcription of genes involved in differentiation of myeloid cells.R-HSA-8939246<Regulation of PAK-2p34 activity by PS-GAP-RHG10.R-HSA-2117284Regulation of TLR by endogenous ligand.R-HSA-56869389Regulation of MECP2 expression and activity.R-HSA-9022692)Regulation of KIT signaling.R-HSA-1433559ePhosphorylation of proteins involved in G1-S transition by active Cyclin E:Cdk2 complexes.R-HSA-69200CPlasma lipoprotein assembly, remodeling, and clearance.R-HSA-174824*Plasma lipoprotein clearance.R-HSA-8964043 Parasite infection.R-HSA-9664407PTK6 Expression.R-HSA-8849473VOxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.R-HSA-1234176GRegulation of actin dynamics for phagocytic cup formation.R-HSA-2029482PCP-CE pathway.R-HSA-4086400,PI3K events in ERBB4 signaling.R-HSA-1250342=Regulation of TP53 Activity through Methylation.R-HSA-6804760*PI3K-AKT Signaling in Cancer.R-HSA-2219528=Regulation of TP53 Activity through Acetylation.R-HSA-6804758 PI3K-AKT activation.R-HSA-198203+Regulation of TNFR1 signaling.R-HSA-5357905-PI5P Regulates TP53 Acetylation.R-HSA-6811555%PLC beta mediated events.R-HSA-112043-PLCG1 events in ERBB2 signaling.R-HSA-1251932"PTK6 Activates STAT3.R-HSA-88494744Post-translational protein modification.R-HSA-5975925Pre-NOTCH Transcription and Translation.R-HSA-19124081Pre-NOTCH Expression and Processing.R-HSA-1912422.RUNX2 regulates bone development.R-HSA-8941326!RHO GTPase Effectors.R-HSA-1952582RHO GTPases Activate WASPs and WAVEs.R-HSA-5663213)RHO GTPases activate IQGAPs.R-HSA-5626467+RNA Polymerase II Transcription.R-HSA-73857'ROBO receptors bind AKAP5.R-HSA-9010642FRUNX1 regulates estrogen receptor mediated transcription.R-HSA-8931987IRUNX1 regulates expression of components of tight junctions.R-HSA-8935964$RAF-MAP kinase cascade.R-HSA-56730012RUNX3 regulates CDKN1A transcription.R-HSA-8941855Protein folding.R-HSA-3912514Processing of Capped Intronless Pre-mRNA.R-HSA-75067.Processing of Intronless Pre-mRNAs.R-HSA-77595#Programmed Cell Death.R-HSA-5357801-Regulation of Complement cascade.R-HSA-977606=Purinergic signaling in leishmaniasis infection.R-HSA-9660826Protein repair.R-HSA-5676934%RUNX3 regulates p14-ARF.R-HSA-8951936:RUNX3 regulates RUNX1-mediated transcription.R-HSA-89519116Protein-protein interactions at synapses.R-HSA-6794362-RUNX3 regulates NOTCH signaling.R-HSA-8941856*Other semaphorin interactions.R-HSA-416700;Proton-coupled neutral amino acid transporters.R-HSA-428559,Ovarian tumor domain proteases.R-HSA-5689896QNegative regulation of NMDA receptor-mediated neuronal transmission.R-HSA-9617324&Oncogenic MAPK signaling.R-HSA-6802957,MAPK family signaling cascades.R-HSA-5683057VLRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.R-HSA-3134973"Laminin interactions.R-HSA-3000157)Late Phase of HIV Life Cycle.R-HSA-162599"Leishmania infection.R-HSA-9658195%Leishmania phagocytosis.R-HSA-9664417$Long-term potentiation.R-HSA-9620244/Lysosphingolipid and LPA receptors.R-HSA-419408M Phase.R-HSA-68886$MAPK1 (ERK2) activation.R-HSA-112411#MAPK1-MAPK3 signaling.R-HSA-5684996.MET activates PI3K-AKT signaling.R-HSA-8851907)MET activates RAP1 and RAC1.R-HSA-8875555)MET activates RAS signaling.R-HSA-8851805-MET interacts with TNS proteins.R-HSA-8875513#LGI-ADAM interactions.R-HSA-5682910 Killing mechanisms.R-HSA-9664420,Ion transport by P-type ATPases.R-HSA-936837"Ion channel transport.R-HSA-983712/Integrin cell surface interactions.R-HSA-2160832Interaction between PHLDA1 and AURKA.R-HSA-8854521,Interleukin-12 family signaling.R-HSA-447115&Interleukin-12 signaling.R-HSA-9020591-Interleukin-20 family signaling.R-HSA-8854691&Interleukin-21 signaling.R-HSA-9020958&Interleukin-27 signaling.R-HSA-9020956&Interleukin-37 signaling.R-HSA-9008059,Interleukin-6 family signaling.R-HSA-6783589%Interleukin-6 signaling.R-HSA-1059683#Intestinal absorption.R-HSA-8963676*Intestinal hexose absorption.R-HSA-8981373<Intra-Golgi and retrograde Golgi-to-ER traffic.R-HSA-6811442/MHC class II antigen presentation.R-HSA-2132295MTOR signalling.R-HSA-165159VNF-kB activation through FADD-RIP-1 pathway mediated by caspase-8 and -10.R-HSA-933543.NOSTRIN mediated eNOS trafficking.R-HSA-203641ANOTCH3 Intracellular Domain Regulates Transcription.R-HSA-9013508WNef mediated downregulation of MHC class I complex cell surface expression.R-HSA-164940:Negative feedback regulation of MAPK pathway.R-HSA-56744991Negative regulation of MAPK pathway.R-HSA-5675221_Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.R-HSA-446388(Nervous system development.R-HSA-9675108'Neurexins and neuroligins.R-HSA-67943619Neurophilin interactions with VEGF and VEGFR.R-HSA-194306&Neutrophil degranulation.R-HSA-6798695,Notch-HLH transcription pathway.R-HSA-350054hNucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways.R-HSA-168643,NGF-independant TRKA activation.R-HSA-187024Macroautophagy.R-HSA-1632852NCAM1 interactions.R-HSA-419037!Membrane Trafficking.R-HSA-1999910Metabolism of fat-soluble vitamins.R-HSA-68066671Metabolism of vitamins and cofactors.R-HSA-196854]Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane.R-HSA-190840:Mitochondrial iron-sulfur cluster biogenesis.R-HSA-1362409Mitotic Anaphase.R-HSA-68882,Mitotic Metaphase and Anaphase.R-HSA-2555396 Mitotic Prometaphase.R-HSA-68877-Molybdenum cofactor biosynthesis.R-HSA-947581,MyD88-independent TLR4 cascade .R-HSA-166166BMyD88:MAL(TIRAP) cascade initiated on plasma membrane.R-HSA-166058NADPH regeneration.R-HSA-3895422NCAM signaling for neurite out-growth.R-HSA-3751657Regulation of cortical dendrite branching.R-HSA-89858011SLIT2:ROBO1 increases RHOA activity.R-HSA-8985586GRegulation of gene expression by Hypoxia-inducible Factor.R-HS< A-1234158TCR signaling.R-HSA-2024035Synthesis of PIPs at the Golgi membrane.R-HSA-1660514)Transport of small molecules.R-HSA-382551RTAK1 activates NFkB by phosphorylation and activation of IKKs complex.R-HSA-445989&Suppression of apoptosis.R-HSA-9635465?Transport of connexins along the secretory pathway.R-HSA-190827_TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.R-HSA-88669104Translation initiation complex formation.R-HSA-72649?Transport to the Golgi and subsequent modification.R-HSA-948021DRegulation of innate immune responses to cytosolic DNA.R-HSA-3134975?Stimulation of the cell death response by PAK-2p34.R-HSA-211736Signalling to RAS.R-HSA-167044.Signalling to p38 via RIT and RIN.R-HSA-187706JSodium-coupled sulphate, di- and tri-carboxylate transporters.R-HSA-433137*Viral Messenger RNA Synthesis.R-HSA-168325(Vesicle-mediated transport.R-HSA-56536563VLDLR internalisation and degradation.R-HSA-8866427 Stabilization of p53.R-HSA-69541ETristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.R-HSA-450513&Stimuli-sensing channels.R-HSA-2672351*Sulfur amino acid metabolism.R-HSA-16146355Uptake and function of diphtheria toxin.R-HSA-5336415,Unfolded Protein Response (UPR).R-HSA-381119.Ub-specific processing proteases.R-HSA-5689880ATranscriptional regulation of pluripotent stem cells.R-HSA-452723\TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.R-HSA-5676594:Transcriptional regulation of granulopoiesis.R-HSA-9616222<Tat-mediated elongation of the HIV-1 transcript.R-HSA-1672462TRIF(TICAM1)-mediated TLR4 signaling .R-HSA-9370619Toxicity of botulinum toxin type C (BoNT-C).R-HSA-5250971(Toll-like Receptor Cascades.R-HSA-1688981Toll Like Receptor TLR6:TLR2 Cascade.R-HSA-1681881TRIF-mediated programmed cell death.R-HSA-2562578#TRKA activation by NGF.R-HSA-1870421TYSND1 cleaves peroxisomal proteins.R-HSA-90335006Termination of translesion DNA synthesis.R-HSA-5656169TNF signaling.R-HSA-75893#The NLRP1 inflammasome.R-HSA-844455.The activation of arylsulfatases.R-HSA-16631501Toll Like Receptor TLR1:TLR2 Cascade.R-HSA-1681790Toll Like Receptor 4 (TLR4) Cascade.R-HSA-166016(Tight junction interactions.R-HSA-4200290Toll Like Receptor 2 (TLR2) Cascade.R-HSA-181438,Transcription of the HIV genome.R-HSA-167172ITRAF6-mediated induction of TAK1 complex within TLR4 complex.R-HSA-937072,TRAF6 mediated NF-kB activation.R-HSA-933542+TRAF6 mediated IRF7 activation.R-HSA-9335416TNFR1-induced NFkappaB signaling pathway.R-HSA-53579565TNFs bind their physiological receptors.R-HSA-5669034\Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors.R-HSA-8864260,TP53 Regulates Metabolic Genes.R-HSA-56288971Transcriptional regulation by RUNX3.R-HSA-88781591Transcriptional regulation by RUNX1.R-HSA-8878171>TP53 Regulates Transcription of Cell Death Genes.R-HSA-5633008HTranscriptional activity of SMAD2-SMAD3:SMAD4 heterotrimer.R-HSA-2173793TTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest.R-HSA-6804116~TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.R-HSA-68041153TRAF3-dependent IRF activation pathway.R-HSA-9182330Transcriptional Regulation by TP53.R-HSA-37009891Transcriptional Regulation by MECP2.R-HSA-8986944Signalling to ERK5.R-HSA-198765'Virus Assembly and Release.R-HSA-168268/SUMO is proteolytically processed.R-HSA-3065679<SUMOylation of chromatin organization proteins.R-HSA-45516382SUMOylation of transcription factors.R-HSA-3232118-Scavenging by Class A Receptors.R-HSA-3000480Signaling by EGFR.R-HSA-1779290Sema3A PAK dependent Axon repulsion.R-HSA-399954$Semaphorin interactions.R-HSA-373755-Separation of Sister Chromatids.R-HSA-2467813 Signal Transduction.R-HSA-162582:Signal regulatory protein family interactions.R-HSA-391160&Signal transduction by L1.R-HSA-445144/Signaling by BRAF and RAF fusions.R-HSA-6802952?STING mediated induction of host immune responses.R-HSA-18349414STAT6-mediated induction of chemokines.R-HSA-3249367STAT5 Activation.R-HSA-9645135$SOS-mediated signalling.R-HSA-112412+Regulation of signaling by CBL.R-HSA-912631RRemoval of aminoterminal propeptides from gamma-carboxylated proteins.R-HSA-1597825Resolution of Sister Chromatid Cohesion.R-HSA-25002578Response to elevated platelet cytosolic Ca2+.R-HSA-76005.Retinoid metabolism and transport.R-HSA-975634/Retrograde neurotrophin signalling.R-HSA-177504=Retrograde transport at the Trans-Golgi-Network.R-HSA-6811440:Ribosomal scanning and start codon recognition.R-HSA-72702/Role of ABL in ROBO-SLIT signaling.R-HSA-428890*SHC1 events in EGFR signaling.R-HSA-180336,SHC1 events in ERBB2 signaling.R-HSA-1250196,SHC1 events in ERBB4 signaling.R-HSA-12503470trans-Golgi Network Vesicle Budding.R-HSA-199992&Visual phototransduction.R-HSA-2187338!Signaling by NOTCH3.R-HSA-9012852Signaling by NTRKs.R-HSA-166520,Signaling by Nuclear Receptors.R-HSA-9006931ASignaling by Overexpressed Wild-Type EGFR in Cancer.R-HSA-56383029XAV939 inhibits tankyrase, stabilizing AXIN.R-HSA-5545619DWNT5A-dependent internalization of FZD2, FZD5 and ROR2.R-HSA-51407453WNT5:FZD7-mediated leishmania damping.R-HSA-9673324%Signaling by Rho GTPases.R-HSA-1943153Signaling by TGF-beta Receptor Complex.R-HSA-1708349Signaling by cytosolic FGFR1 fusion mutants.R-HSA-18391178Signaling by plasma membrane FGFR1 fusions.R-HSA-8853336!Signaling by NOTCH2.R-HSA-1980145Signaling by MET.R-HSA-6806834,Signaling by ERBB2 ECD mutants.R-HSA-9665348+Signaling by ERBB2 KD Mutants.R-HSA-9664565:rRNA modification in the nucleus and cytosol.R-HSA-6790901 Signaling by ERBB4.R-HSA-1236394'mTORC1-mediated signalling.R-HSA-166208)Signaling by Erythropoietin.R-HSA-90063356Signaling by FGFR1 amplification mutants.R-HSA-1839120.XBP1(S) activates chaperone genes.R-HSA-381038#Signaling by Hedgehog.R-HSA-5358351&Signaling by Interleukins.R-HSA-449147!Signaling by Leptin.R-HSA-2586552FLT3 Signaling.R-HSA-9607240>TP53 Regulates Transcription of DNA Repair Genes.R-HSA-6796648>Synthesis of PIPs at the early endosome membrane.R-HSA-1660516=Synthesis of PIPs at the late endosome membrane.R-HSA-1660517+Synthesis of diphthamide-EEF2.R-HSA-5358493=Synthesis, secretion, and deacylation of Ghrelin.R-HSA-422085TBC-RABGAPs.R-HSA-8854214>TICAM1,TRAF6-dependent induction of TAK1 complex.R-HSA-9014325BTLR3-mediated TICAM1-dependent programmed cell death.R-HSA-90139572TNFR1-induced proapoptotic signaling.R-HSA-53577869Telomere C-strand (Lagging Strand) Synthesis.R-HSA-174417<Synthesis of Leukotrienes (LT) and Eoxins (EX).R-HSA-2142691+Terminal pathway of complement.R-HSA-166665Tie2 Signaling.R-HSA-210993DTranslocation of SLC2A4 (GLUT4) to the plasma membrane.R-HSA-1445148=Translocation of ZAP-70 to Immunological synapse.R-HSA-202430%Transport of fatty acids.R-HSA-8049141Vif-mediated degradation of APOBEC3G.R-HSA-180585-Vitamin C (ascorbate) metabolism.R-HSA-196836Xenobiotics.R-HSA-211981(Synthesis of Lipoxins (LX).R-HSA-2142700ASynthesis And Processing Of GAG, GAGPOL Polyproteins.R-HSA-174495:RHO GTPases Activate Rhotekin and Rhophilins.R-HSA-5666185AResponse of EIF2AK4 (GCN2) to amino acid deficiency.R-HSA-9633012/RIPK1-mediated regulated necrosis.R-HSA-5213460 Regulated Necrosis.R-HSA-5218859$Regulation of Apoptosis.R-HSA-169911)Regulation of IFNG signaling.R-HSA-8773123Regulation of PTEN gene transcription.R-HSA-8943724-Regulation of PTEN localization.R-HSA-8948747PRegulation of activated PAK-2p34 by proteasome mediated degradation.R-HSA-211733Relaxin receptors.R-HSA-444821$Response to metal ions.R-HSA-5660526(Striated Muscle Contraction.R-HSA-390522+Retinoid cycle disease events.R-HSA-2453864!Selective autophagy.R-HSA-96638915Serotonin Neurotransmitter Release Cycle.R-HSA-181429"Signaling by Activin.R-HSA-1502540Signaling by MST1.R-HSA-8852405'Signaling by NTRK3 (TRKC).R-HSA-90340155Small interfering RNA (siRNA) biogenesis.R-H< SA-426486+mRNA Editing: C to U Conversion.R-HSA-72200!phospho-PLA2 pathway.R-HSA-111995rActivation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S.R-HSA-72662$Adaptive Immune System.R-HSA-1280218AAdvanced glycosylation endproduct receptor signaling.R-HSA-879415aAmplification of signal from unattached kinetochores via a MAD2 inhibitory signal.R-HSA-141444:Amplification of signal from the kinetochores.R-HSA-1414243Antigen processing-Cross presentation.R-HSA-1236975<APOBEC3G mediated resistance to HIV-1 infection.R-HSA-180689Apoptosis.R-HSA-109581.Asparagine N-linked glycosylation.R-HSA-446203=Assembly of Viral Components at the Budding Site.R-HSA-1683165Asymmetric localization of PCP proteins.R-HSA-4608870LActivation of the TFAP2 (AP-2) family of transcription factors.R-HSA-8866907)Activation of TRKA receptors.R-HSA-1870159Activation of Na-permeable kainate receptors.R-HSA-451307;ARL13B-mediated ciliary trafficking of INPP5E.R-HSA-5624958%ARMS-mediated activation.R-HSA-1709848ATF6 (ATF6-alpha) activates chaperone genes.R-HSA-3811831Activated NTRK2 signals through FYN.R-HSA-90325002Activated NTRK2 signals through PI3K.R-HSA-90283351Activated NTRK2 signals through RAS.R-HSA-90265191Activated NTRK3 signals through RAS.R-HSA-9034864AActivation of BIM and translocation to mitochondria .R-HSA-111446AActivation of IRF3-IRF7 mediated by TBK1-IKK epsilon.R-HSA-9369645Activation of Matrix Metalloproteinases.R-HSA-15923890Activation of NF-kappaB in B cells.R-HSA-1169091AActivation of NMDA receptors and postsynaptic events.R-HSA-4427553RHO GTPases regulate CFTR trafficking.R-HSA-5627083%RAB geranylgeranylation.R-HSA-8873719!Innate Immune System.R-HSA-1682492ER Quality Control Compartment (ERQC).R-HSA-901032(Dimerization of procaspase-8.R-HSA-69416@Diseases associated with the TLR signaling cascade.R-HSA-5602358:Diseases associated with visual transduction.R-HSA-2474795'Diseases of Immune System.R-HSA-5260271-Diseases of the neuronal system.R-HSA-9675143-Disinhibition of SNARE formation.R-HSA-1145164Dopamine Neurotransmitter Release Cycle.R-HSA-2126760EPHA-mediated growth cone collapse.R-HSA-3928663Endogenous sterols.R-HSA-2119769Cytochrome P450 - arranged by substrate type.R-HSA-2118979Estrogen-stimulated signaling through PRKCZ.R-HSA-9634635IEvents associated with phagocytolytic activity of PMN cells.R-HSA-8941413#Extension of Telomeres.R-HSA-180786!FasL- CD95L signaling.R-HSA-75157Fertilization.R-HSA-1187000&Formation of the Editosome.R-HSA-750941Formation of the cornified envelope.R-HSA-6809371,GP1b-IX-V activation signalling.R-HSA-430116.DCC mediated attractive signaling.R-HSA-4188850Chemokine receptors bind chemokines.R-HSA-3801087Prevention of phagosomal-lysosomal fusion.R-HSA-9636383)CASP8 activity is inhibited.R-HSA-5218900$Activation of C3 and C5.R-HSA-174577,Adherens junctions interactions.R-HSA-418990.Alternative complement activation.R-HSA-173736$Antimicrobial peptides.R-HSA-68031572Aryl hydrocarbon receptor signalling.R-HSA-8937144'Assembly Of The HIV Virion.R-HSA-175474<Autodegradation of the E3 ubiquitin ligase COP1.R-HSA-349425DBiosynthesis of A2E, implicated in retinal degradation.R-HSA-2466712 CD28 co-stimulation.R-HSA-3893563Cell-extracellular matrix interactions.R-HSA-446353.CD28 dependent PI3K-Akt signaling.R-HSA-389357CHL1 interactions.R-HSA-447041)CLEC7A-inflammasome pathway.R-HSA-5660668!CREB phosphorylation.R-HSA-199920*CREB3 factors activate genes.R-HSA-8874211 Cardiac conduction.R-HSA-5576891'Cell junction organization.R-HSA-446728,Cell-cell junction organization.R-HSA-421270-GPVI-mediated activation cascade.R-HSA-114604"Gene Silencing by RNA.R-HSA-211000"Hedgehog 'off' state.R-HSA-5610787-O-linked glycosylation of mucins.R-HSA-9137090Mtb iron assimilation by chelation.R-HSA-1222449*NGF-stimulated transcription.R-HSA-9031628QNR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake .R-HSA-90315255NRIF signals cell death from the nucleus.R-HSA-205043(Nephrin family interactions.R-HSA-373753%Neurofascin interactions.R-HSA-447043?O-glycosylation of TSR domain-containing proteins.R-HSA-5173214$O-linked glycosylation.R-HSA-5173105Heme biosynthesis.R-HSA-189451$Organic anion transport.R-HSA-561048+PERK regulates gene expression.R-HSA-3810425PIWI-interacting RNA (piRNA) biogenesis.R-HSA-5601884(Peptide hormone metabolism.R-HSA-29807365Phase I - Functionalization of compounds.R-HSA-2119451Platelet Adhesion to exposed collagen.R-HSA-75892APolymerase switching on the C-strand of the telomere.R-HSA-174411 Polymerase switching.R-HSA-690915Modulation by Mtb of host immune system.R-HSA-9637628%Metabolism of vitamin K.R-HSA-6806664%Metabolism of porphyrins.R-HSA-189445<Membrane binding and targetting of GAG proteins.R-HSA-174490*IkBA variant leads to EDA-ID.R-HSA-5603029UImmunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.R-HSA-198933^Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs-IMPs-VICKZs) bind RNA.R-HSA-4283590Interaction between L1 and Ankyrins.R-HSA-445095&Interleukin-18 signaling.R-HSA-9012546&Interleukin-33 signaling.R-HSA-9014843$Interleukin-36 pathway.R-HSA-9014826!Intra-Golgi traffic.R-HSA-6811438,Intracellular oxygen transport.R-HSA-8981607Ion homeostasis.R-HSA-5578775:Ion influx-efflux at host-pathogen interface.R-HSA-6803544Keratinization.R-HSA-6805567L1CAM interactions.R-HSA-373760$Lagging Strand Synthesis.R-HSA-69186$Leading Strand Synthesis.R-HSA-69109)Lipid particle organization.R-HSA-8964572*MET activates PTK2 signaling.R-HSA-8874081-Attachment of GPI anchor to uPAR.R-HSA-162791Attenuation phase.R-HSA-33715683Fc epsilon receptor (FCERI) signaling.R-HSA-2454202<Fcgamma receptor (FCGR) dependent phagocytosis.R-HSA-2029480*Fibronectin matrix formation.R-HSA-1566977)Folding of actin by CCT-TriC.R-HSA-390450JFormation of HIV elongation complex in the absence of HIV Tat.R-HSA-167152GFormation of HIV-1 elongation complex containing HIV-1 Tat.R-HSA-167200:ALKBH2 mediated reversal of alkylation damage.R-HSA-1121226Formation of TC-NER Pre-Incision Complex.R-HSA-6781823/Formation of annular gap junctions.R-HSA-1960256Formation of the Early Elongation Complex.R-HSA-113418<Formation of the HIV-1 Early Elongation Complex.R-HSA-167158FFormation of the beta-catenin:TCF transactivating complex.R-HSA-201722OFormation of the ternary complex, and subsequently, the 43S complex.R-HSA-72695*G alpha (i) signalling events.R-HSA-418594RFactors involved in megakaryocyte development and platelet production.R-HSA-983231(FGFR2 alternative splicing.R-HSA-6803529Autophagy.R-HSA-9612973GErythropoietin activates Phosphoinositide-3-kinase (PI3K).R-HSA-9027276+ERBB2 Regulates Cell Motility.R-HSA-6785631!ERKs are inactivated.R-HSA-202670$ESR-mediated signaling.R-HSA-8939211/Elevation of cytosolic Ca2+ levels.R-HSA-139853EEntry of Influenza Virion into Host Cell via Endocytosis.R-HSA-168275Ephrin signaling.R-HSA-3928664*FCGR3A-mediated phagocytosis.R-HSA-9664422*Erythropoietin activates RAS.R-HSA-9027284,Erythropoietin activates STAT5.R-HSA-9027283"Estrogen biosynthesis.R-HSA-1931440Estrogen-dependent gene expression.R-HSA-9018519.FCERI mediated Ca+2 mobilization.R-HSA-2871809,FCERI mediated MAPK activation.R-HSA-2871796-FCERI mediated NF-kB activation.R-HSA-2871837,G-protein beta:gamma signalling.R-HSA-3977957Infection with Mycobacterium tuberculosis.R-HSA-96354863HuR (ELAVL1) binds and stabilizes mRNA.R-HSA-4505205IKK complex recruitment mediated by RIP1.R-HSA-937041=IL-6-type cytokine receptor ligand interactions.R-HSA-6788467+IRE1alpha activates chaperones.R-HSA-381070GAB1 signalosome.R-HSA-180292Inflammasomes.R-HSA-622312;Inhibition of Signaling by Overexpressed EGFR.R-HSA-56383037Inhibition of TSC complex formation by PKB.R-HSA-1651819Heparan sulfate-heparin (HS-GAG) metabolism.R-HSA-1638091(Hedgehog ligand biogenesis.R-HSA-5358346!Hedgehog 'on' state.R-HSA-563268<4,HSF1-dependent transactivation.R-HSA-3371571:GLI3 is processed to GLI3R by the proteasome.R-HSA-5610785*GRB2 events in EGFR signaling.R-HSA-179812,GRB2 events in ERBB2 signaling.R-HSA-1963640%Gap junction degradation.R-HSA-190873=Gastrin-CREB signalling pathway via PKC and MAPK.R-HSA-881907`Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation.R-HSA-8950505*Generic Transcription Pathway.R-HSA-212436*Glycosphingolipid metabolism.R-HSA-1660662.Golgi-to-ER retrograde transport.R-HSA-8856688HIV Life Cycle.R-HSA-162587)HIV Transcription Elongation.R-HSA-167169 HS-GAG degradation.R-HSA-2024096HSF1 activation.R-HSA-3371511,ERBB2 Activates PTK6 Signaling.R-HSA-8847993"ER-Phagosome pathway.R-HSA-1236974.ER to Golgi Anterograde Transport.R-HSA-199977:Cell recruitment (pro-inflammatory response).R-HSA-9664424(Calcineurin activates NFAT.R-HSA-2025928&Calmodulin induced events.R-HSA-111933+Cargo concentration in the ER.R-HSA-5694530MCaspase activation via Death Receptors in the presence of ligand.R-HSA-140534KCaspase activation via extrinsic apoptotic signalling pathway.R-HSA-5357769;Cell surface interactions at the vascular wall.R-HSA-202733Circadian Clock.R-HSA-400253!Cellular Senescence.R-HSA-2559583.Cellular response to heat stress.R-HSA-3371556*Cellular response to hypoxia.R-HSA-12341744Cellular responses to external stimuli.R-HSA-8953897*Cellular responses to stress.R-HSA-22627520Chaperonin-mediated protein folding.R-HSA-390466JChk1-Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.R-HSA-75035)Chromatin modifying enzymes.R-HSA-32475095CaMK IV-mediated phosphorylation of CREB.R-HSA-111932CaM pathway.R-HSA-111997Ca2+ pathway.R-HSA-4086398 Ca-dependent events.R-HSA-111996Axon guidance.R-HSA-4224757BBSome-mediated cargo-targeting to cilium.R-HSA-5620922!Basigin interactions.R-HSA-2109914Beta-catenin independent WNT signaling.R-HSA-38584941Beta-catenin phosphorylation cascade.R-HSA-1962991Blockage of phagosome acidification.R-HSA-96364674Butyrophilin (BTN) family interactions.R-HSA-88516807CLEC7A (Dectin-1) induces NFAT activation.R-HSA-56077631COPI-mediated anterograde transport.R-HSA-6807878-COPII-mediated vesicle transport.R-HSA-204005YCREB1 phosphorylation through the activation of CaMKII-CaMKK-CaMKIV cascasde.R-HSA-442729&CRMPs in Sema3A signaling.R-HSA-399956$Chromatin organization.R-HSA-48397264EPH-ephrin mediated repulsion of cells.R-HSA-3928665!Degradation of AXIN.R-HSA-46412577Detoxification of Reactive Oxygen Species.R-HSA-3299685#Developmental Biology.R-HSA-1266738\Disassembly of the destruction complex and recruitment of AXIN to the membrane.R-HSA-4641262^Diseases of signal transduction by growth factor receptors and second messengers.R-HSA-5663202;Downregulation of TGF-beta receptor signaling.R-HSA-2173788%Downstream TCR signaling.R-HSA-202424BDownstream signaling events of B Cell Receptor (BCR).R-HSA-1168372-EGFR Transactivation by Gastrin.R-HSA-2179392"EPH-Ephrin signaling.R-HSA-2682334%Death Receptor Signalling.R-HSA-73887BCobalamin (Cbl, vitamin B12) transport and metabolism.R-HSA-196741Complement cascade.R-HSA-166658?Constitutive Signaling by Aberrant PI3K in Cancer.R-HSA-2219530-Costimulation by the CD28 family.R-HSA-388841;Cytosolic sensors of pathogen-associated DNA .R-HSA-1834949#DAG and IP3 signaling.R-HSA-1489509DDDX58-IFIH1-mediated induction of interferon-alpha-beta.R-HSA-168928 Transcription InflammationDNA damage responseGrowth signallingiSupplementary Table 3. Gene expression pathway analysis of Bloom syndrome and Nijmegen breakage syndrome. ;1 2Q47 :*< >Y u@F(BEDFkHXJZtLE{NLPl8SUW>eYQ[ ] ^ `igc,fzh'~j+l.yn&qr|tXwy\|5 ~l h> %/"Ae tR * ٟF xR[~Ȭ5ڮG! 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