Supplementary Table 4. KEGG. ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count hsa04512 ECM-receptor interaction Aug-90 88/8378 4.13E-06 4.13E-06 0.000547203 IBSP/FN1/COMP/LAMB2/ITGA1/LAMA4/COL1A1/HSPG2 8 hsa04510 Focal adhesion Nov-90 203/8378 1.01E-05 1.01E-05 0.00066669 IBSP/FN1/COMP/LAMB2/ITGA1/MYLK/PDGFRA/FLNC/LAMA4/COL1A1/MYL9 11 hsa04974 Protein digestion and absorption Jul-90 103/8378 0.000112028 0.000112028 0.004952838 COL10A1/COL11A1/COL13A1/COL5A1/COL1A1/COL5A2/DPP4 7 hsa04810 Regulation of actin cytoskeleton Oct-90 229/8378 0.000161235 0.000161235 0.005346201 CXCL12/GSN/FGF1/FN1/ITGA1/MYLK/PDGFRA/LPAR1/BDKRB2/MYL9 10 hsa04350 TGF-beta signaling pathway Jun-90 98/8378 0.000619501 0.000619501 0.016433066 INHBA/DCN/BMP8A/FMOD/LRRC32/FBN1 6 hsa05202 Transcriptional misregulation in cancer Aug-90 193/8378 0.001058317 0.001058317 0.02339437 RUNX1T1/POLK/MITF/PLAU/ZEB1/MMP3/PLAT/RUNX2 8 hsa05205 Proteoglycans in cancer Aug-90 205/8378 0.001558101 0.001558101 0.029521911 DCN/FN1/PLAU/FLNC/COL1A1/TIMP3/HSPG2/TWIST1 8 hsa04610 Complement and coagulation cascades May-90 86/8378 0.00224837 0.00224837 0.037275611 PLAU/CFH/F13A1/PLAT/BDKRB2 5 hsa05215 Prostate cancer May-90 97/8378 0.003794456 0.003794456 0.055918294 PLAU/ZEB1/MMP3/PDGFRA/PLAT 5 hsa04151 PI3K-Akt signaling pathway Oct-90 354/8378 0.00450646 0.00450646 0.059769894 IBSP/FGF1/FN1/COMP/LAMB2/ITGA1/PDGFRA/LPAR1/LAMA4/COL1A1 10 hsa05218 Melanoma Apr-90 72/8378 0.007349082 0.007349082 0.088610939 FGF1/POLK/MITF/PDGFRA 4 hsa05165 Human papillomavirus infection Sep-90 331/8378 0.008905873 0.008905873 0.098433336 IBSP/FN1/COMP/LAMB2/ITGA1/AXIN2/LAMA4/COL1A1/ATP6V0D2 9 hsa04360 Axon guidance Jun-90 182/8378 0.013366433 0.013366433 0.136370085 SLIT3/CXCL12/UNC5B/SEMA5A/NRP1/MYL9 6 hsa05222 Small cell lung cancer Apr-90 92/8378 0.016984073 0.016984073 0.16090174 POLK/FN1/LAMB2/LAMA4 4 hsa05146 Amoebiasis Apr-90 102/8378 0.023836852 0.023836852 0.210767954 FN1/LAMB2/LAMA4/COL1A1 4 hsa04310 Wnt signaling pathway May-90 170/8378 0.035817078 0.035817078 0.296904726 PRICKLE2/DAAM2/SERPINF1/AXIN2/SFRP4 5 hsa04270 Vascular smooth muscle contraction Apr-90 134/8378 0.055802759 0.055802759 0.435365176 MYLK/ACTA2/PRKG1/MYL9 4 hsa04540 Gap junction Mar-90 88/8378 0.068559549 0.068559549 0.505175623 PDGFRA/LPAR1/PRKG1 3 hsa05323 Rheumatoid arthritis Mar-90 93/8378 0.078091651 0.078091651 0.545127316 CXCL12/MMP3/ATP6V0D2 3 hsa04390 Hippo signaling pathway Apr-90 157/8378 0.088280685 0.088280685 0.585440331 FGF1/BMP8A/FRMD6/AXIN2 4 hsa05144 Malaria Feb-90 50/8378 0.100424023 0.100424023 0.6076285 COMP/LRP1 2 hsa04022 cGMP-PKG signaling pathway Apr-90 167/8378 0.10473035 0.10473035 0.6076285 MYLK/BDKRB2/PRKG1/MYL9 4 hsa04928 "Parathyroid hormone synthesis, secretion and action" Mar-90 106/8378 0.105370498 0.105370498 0.6076285 MMP13/MMP14/RUNX2 3 hsa05206 MicroRNAs in cancer Jun-90 310/8378 0.11577941 0.11577941 0.639833581 RECK/PLAU/ZEB1/PDGFRA/ZFPM2/TIMP3 6 hsa04670 Leukocyte transendothelial migration Mar-90 114/8378 0.123776762 0.123776762 0.65505358 CXCL12/MYL9/THY1 3 hsa05213 Endometrial cancer Feb-90 58/8378 0.128411297 0.128411297 0.65505358 POLK/AXIN2 2 hsa05217 Basal cell carcinoma Feb-90 63/8378 0.146727879 0.146727879 0.702414389 POLK/AXIN2 2 hsa04611 Platelet activation Mar-90 124/8378 0.148287482 0.148287482 0.702414389 MYLK/COL1A1/PRKG1 3 hsa04926 Relaxin signaling pathway Mar-90 129/8378 0.161095596 0.161095596 0.736771146 MMP13/ACTA2/COL1A1 3 hsa04371 Apelin signaling pathway Mar-90 139/8378 0.187657839 0.187657839 0.771674691 MYLK/ACTA2/PLAT 3 hsa04015 Rap1 signaling pathway Apr-90 210/8378 0.188990575 0.188990575 0.771674691 FGF1/PRKD1/PDGFRA/LPAR1 4 hsa05214 Glioma Feb-90 75/8378 0.192531594 0.192531594 0.771674691 POLK/PDGFRA 2 hsa05412 Arrhythmogenic right ventricular cardiomyopathy Feb-90 77/8378 0.200350196 0.200350196 0.771674691 ITGA1/SGCD 2 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Jan-90 21/8378 0.203146088 0.203146088 0.771674691 DSEL 1 hsa04010 MAPK signaling pathway May-90 294/8378 0.208456792 0.208456792 0.771674691 FGF1/RASGRF2/RPS6KA2/PDGFRA/FLNC 5 hsa05224 Breast cancer Mar-90 147/8378 0.209677331 0.209677331 0.771674691 FGF1/POLK/AXIN2 3 hsa05226 Gastric cancer Mar-90 149/8378 0.215272741 0.215272741 0.771674691 FGF1/POLK/AXIN2 3 hsa04145 Phagosome Mar-90 152/8378 0.223725985 0.223725985 0.776451822 COMP/COLEC12/ATP6V0D2 3 hsa05210 Colorectal cancer Feb-90 86/8378 0.235930341 0.235930341 0.776451822 POLK/AXIN2 2 hsa04514 Cell adhesion molecules Mar-90 157/8378 0.237959498 0.237959498 0.776451822 CD276/NEGR1/VCAN 3 hsa05410 Hypertrophic cardiomyopathy Feb-90 90/8378 0.251875065 0.251875065 0.776451822 ITGA1/SGCD 2 hsa04966 Collecting duct acid secretion Jan-90 27/8378 0.253284043 0.253284043 0.776451822 ATP6V0D2 1 hsa04020 Calcium signaling pathway Apr-90 240/8378 0.257365768 0.257365768 0.776451822 FGF1/MYLK/PDGFRA/BDKRB2 4 hsa04657 IL-17 signaling pathway Feb-90 94/8378 0.267851849 0.267851849 0.776451822 MMP13/MMP3 2 hsa04392 Hippo signaling pathway - multiple species Jan-90 29/8378 0.269293211 0.269293211 0.776451822 FRMD6 1 hsa04744 Phototransduction Jan-90 29/8378 0.269293211 0.269293211 0.776451822 GUCA1A 1 hsa05414 Dilated cardiomyopathy Feb-90 96/8378 0.275842518 0.275842518 0.778413377 ITGA1/SGCD 2 hsa04061 Viral protein interaction with cytokine and cytokine receptor Feb-90 100/8378 0.2918103 0.2918103 0.789862465 CXCL12/ACKR4 2 hsa04933 AGE-RAGE signaling pathway in diabetic complications Feb-90 100/8378 0.2918103 0.2918103 0.789862465 FN1/COL1A1 2 hsa04914 Progesterone-mediated oocyte maturation Feb-90 102/8378 0.29978062 0.29978062 0.795207539 RPS6KA2/CPEB2 2 hsa04064 NF-kappa B signaling pathway Feb-90 104/8378 0.307737604 0.307737604 0.795343677 CXCL12/PLAU 2 hsa00500 Starch and sucrose metabolism Jan-90 36/8378 0.322698141 0.322698141 0.795343677 TREH 1 hsa05143 African trypanosomiasis Jan-90 37/8378 0.330005402 0.330005402 0.795343677 LAMA4 1 hsa05216 Thyroid cancer Jan-90 37/8378 0.330005402 0.330005402 0.795343677 POLK 1 hsa05145 Toxoplasmosis Feb-90 112/8378 0.339373286 0.339373286 0.795343677 LAMB2/LAMA4 2 hsa04814 Motor proteins Mar-90 193/8378 0.343443928 0.343443928 0.795343677 KIF26B/ACTA2/MYL9 3 hsa04668 TNF signaling pathway Feb-90 114/8378 0.347220542 0.347220542 0.795343677 MMP14/MMP3 2 hsa04060 Cytokine-cytokine receptor interaction Apr-90 295/8378 0.391397541 0.391397541 0.795343677 INHBA/CXCL12/BMP8A/ACKR4 4 hsa04672 Intestinal immune network for IgA production Jan-90 49/8378 0.411840151 0.411840151 0.795343677 CXCL12 1 hsa04114 Oocyte meiosis Feb-90 131/8378 0.412508645 0.412508645 0.795343677 RPS6KA2/CPEB2 2 hsa04142 Lysosome Feb-90 132/8378 0.416255871 0.416255871 0.795343677 DMXL1/ATP6V0D2 2 hsa00330 Arginine and proline metabolism Jan-90 50/8378 0.418195582 0.418195582 0.795343677 P4HA3 1 hsa05110 Vibrio cholerae infection Jan-90 50/8378 0.418195582 0.418195582 0.795343677 ATP6V0D2 1 hsa04979 Cholesterol metabolism Jan-90 51/8378 0.424483094 0.424483094 0.795343677 LRP1 1 hsa05135 Yersinia infection Feb-90 137/8378 0.434813083 0.434813083 0.795343677 FN1/RPS6KA2 2 hsa04961 Endocrine and other factor-regulated calcium reabsorption Jan-90 53/8378 0.436857223 0.436857223 0.795343677 BDKRB2 1 hsa03460 Fanconi anemia pathway Jan-90 54/8378 0.442945253 0.442945253 0.795343677 POLK 1 hsa04714 Thermogenesis Mar-90 232/8378 0.456621918 0.456621918 0.795343677 BMP8A/RPS6KA2/PRKG1 3 hsa05171 Coronavirus disease - COVID-19 Mar-90 232/8378 0.456621918 0.456621918 0.795343677 MMP3/F13A1/NRP1 3 hsa04550 Signaling pathways regulating pluripotency of stem cells Feb-90 143/8378 0.456666222 0.456666222 0.795343677 INHBA/AXIN2 2 hsa04923 Regulation of lipolysis in adipocytes Jan-90 58/8378 0.466653289 0.466653289 0.795343677 PRKG1 1 hsa04014 Ras signaling pathway Mar-90 236/8378 0.467839871 0.467839871 0.795343677 FGF1/RASGRF2/PDGFRA 3 hsa04072 Phospholipase D signaling pathway Feb-90 148/8378 0.474509527 0.474509527 0.795343677 PDGFRA/LPAR1 2 hsa04730 Long-term depression Jan-90 60/8378 0.478130316 0.478130316 0.795343677 PRKG1 1 hsa04978 Mineral absorption Jan-90 60/8378 0.478130316 0.478130316 0.795343677 CYBRD1 1 hsa05416 Viral myocarditis Jan-90 60/8378 0.478130316 0.478130316 0.795343677 SGCD 1 hsa00140 Steroid hormone biosynthesis Jan-90 62/8378 0.489363057 0.489363057 0.795343677 HSD17B6 1 hsa03250 Viral life cycle - HIV-1 Jan-90 63/8378 0.494889431 0.494889431 0.795343677 MAP1A 1 hsa04921 Oxytocin signaling pathway Feb-90 154/8378 0.495457542 0.495457542 0.795343677 MYLK/MYL9 2 hsa03040 Spliceosome Feb-90 156/8378 0.502324178 0.502324178 0.795343677 SNRPD1/SF3B6 2 hsa05132 Salmonella infection Mar-90 249/8378 0.503581194 0.503581194 0.795343677 AHNAK/FLNC/MYL9 3 hsa04720 Long-term potentiation Jan-90 67/8378 0.516409637 0.516409637 0.795343677 RPS6KA2 1 hsa05221 Acute myeloid leukemia Jan-90 67/8378 0.516409637 0.516409637 0.795343677 RUNX1T1 1 hsa00830 Retinol metabolism Jan-90 68/8378 0.521646447 0.521646447 0.795343677 HSD17B6 1 hsa05120 Epithelial cell signaling in Helicobacter pylori infection Jan-90 70/8378 0.531952404 0.531952404 0.795343677 ATP6V0D2 1 hsa05230 Central carbon metabolism in cancer Jan-90 70/8378 0.531952404 0.531952404 0.795343677 PDGFRA 1 hsa04137 Mitophagy - animal Jan-90 72/8378 0.542038737 0.542038737 0.795343677 MITF 1 hsa05223 Non-small cell lung cancer Jan-90 72/8378 0.542038737 0.542038737 0.795343677 POLK 1 hsa05225 Hepatocellular carcinoma Feb-90 168/8378 0.542260586 0.542260586 0.795343677 POLK/AXIN2 2 hsa04080 Neuroactive ligand-receptor interaction Apr-90 367/8378 0.560383988 0.560383988 0.795343677 LPAR1/BDKRB2/GRP/CHRNA1 4 hsa04971 Gastric acid secretion Jan-90 76/8378 0.56157095 0.56157095 0.795343677 MYLK 1 hsa05212 Pancreatic cancer Jan-90 76/8378 0.56157095 0.56157095 0.795343677 POLK 1 hsa05220 Chronic myeloid leukemia Jan-90 76/8378 0.56157095 0.56157095 0.795343677 POLK 1 hsa05100 Bacterial invasion of epithelial cells Jan-90 77/8378 0.566323855 0.566323855 0.795343677 FN1 1 hsa04721 Synaptic vesicle cycle Jan-90 78/8378 0.571025801 0.571025801 0.795343677 ATP6V0D2 1 hsa01521 EGFR tyrosine kinase inhibitor resistance Jan-90 79/8378 0.575677328 0.575677328 0.795343677 PDGFRA 1 hsa04520 Adherens junction Jan-90 93/8378 0.63579421 0.63579421 0.815147203 MYL9 1 hsa04912 GnRH signaling pathway Jan-90 93/8378 0.63579421 0.63579421 0.815147203 MMP14 1 hsa04970 Salivary secretion Jan-90 93/8378 0.63579421 0.63579421 0.815147203 PRKG1 1 hsa05150 Staphylococcus aureus infection Jan-90 96/8378 0.647536253 0.647536253 0.815147203 CFH 1 hsa05203 Viral carcinogenesis Feb-90 204/8378 0.648496622 0.648496622 0.815147203 GSN/ATP6V0D2 2 hsa04666 Fc gamma R-mediated phagocytosis Jan-90 97/8378 0.651366456 0.651366456 0.815147203 GSN 1 hsa04713 Circadian entrainment Jan-90 97/8378 0.651366456 0.651366456 0.815147203 PRKG1 1 hsa04750 Inflammatory mediator regulation of TRP channels Jan-90 98/8378 0.655155493 0.655155493 0.815147203 BDKRB2 1 hsa04925 Aldosterone synthesis and secretion Jan-90 98/8378 0.655155493 0.655155493 0.815147203 PRKD1 1 hsa05231 Choline metabolism in cancer Jan-90 98/8378 0.655155493 0.655155493 0.815147203 PDGFRA 1 hsa04640 Hematopoietic cell lineage Jan-90 99/8378 0.658903803 0.658903803 0.815147203 ITGA1 1 hsa04916 Melanogenesis Jan-90 101/8378 0.666279967 0.666279967 0.815147203 MITF 1 hsa05142 Chagas disease Jan-90 102/8378 0.669908674 0.669908674 0.815147203 BDKRB2 1 hsa04931 Insulin resistance Jan-90 108/8378 0.690875801 0.690875801 0.833017712 RPS6KA2 1 hsa05163 Human cytomegalovirus infection Feb-90 225/8378 0.701037072 0.701037072 0.837654539 CXCL12/PDGFRA 2 hsa04726 Serotonergic synapse Jan-90 115/8378 0.713677535 0.713677535 0.84514445 KCND2 1 hsa04722 Neurotrophin signaling pathway Jan-90 119/8378 0.725951812 0.725951812 0.851509099 RPS6KA2 1 hsa04071 Sphingolipid signaling pathway Jan-90 121/8378 0.731892344 0.731892344 0.851509099 BDKRB2 1 hsa05131 Shigellosis Feb-90 247/8378 0.749014364 0.749014364 0.854912339 CBX3/MYL9 2 hsa04380 Osteoclast differentiation Jan-90 128/8378 0.751698734 0.751698734 0.854912339 MITF 1 hsa04144 Endocytosis Feb-90 251/8378 0.757001678 0.757001678 0.854912339 PDGFRA/DAB2 2 hsa00190 Oxidative phosphorylation Jan-90 134/8378 0.767518991 0.767518991 0.854912339 ATP6V0D2 1 hsa05322 Systemic lupus erythematosus Jan-90 136/8378 0.772567593 0.772567593 0.854912339 SNRPD1 1 hsa04915 Estrogen signaling pathway Jan-90 138/8378 0.77750775 0.77750775 0.854912339 FKBP4 1 hsa05418 Fluid shear stress and atherosclerosis Jan-90 139/8378 0.779937884 0.779937884 0.854912339 PLAT 1 hsa01240 Biosynthesis of cofactors Jan-90 153/8378 0.811327042 0.811327042 0.874356329 HSD17B6 1 hsa04934 Cushing syndrome Jan-90 155/8378 0.815433713 0.815433713 0.874356329 AXIN2 1 hsa04150 mTOR signaling pathway Jan-90 156/8378 0.817453774 0.817453774 0.874356329 RPS6KA2 1 hsa05161 Hepatitis B Jan-90 162/8378 0.829123055 0.829123055 0.879135892 HSPG2 1 hsa04630 JAK-STAT signaling pathway Jan-90 166/8378 0.836489553 0.836489553 0.879135892 PDGFRA 1 hsa04530 Tight junction Jan-90 169/8378 0.841807503 0.841807503 0.879135892 MYL9 1 hsa05152 Tuberculosis Jan-90 180/8378 0.859883674 0.859883674 0.879264266 ATP6V0D2 1 hsa04621 NOD-like receptor signaling pathway Jan-90 186/8378 0.868866131 0.868866131 0.879264266 ANTXR2 1 hsa04062 Chemokine signaling pathway Jan-90 192/8378 0.87727874 0.87727874 0.879264266 CXCL12 1 hsa05130 Pathogenic Escherichia coli infection Jan-90 197/8378 0.883879819 0.883879819 0.879264266 LPAR1 1 hsa05169 Epstein-Barr virus infection Jan-90 202/8378 0.890129566 0.890129566 0.879264266 POLK 1 hsa05415 Diabetic cardiomyopathy Jan-90 203/8378 0.891339001 0.891339001 0.879264266 COL1A1 1 hsa05207 Chemical carcinogenesis - receptor activation Jan-90 212/8378 0.9016481 0.9016481 0.879264266 RPS6KA2 1 hsa05417 Lipid and atherosclerosis Jan-90 215/8378 0.904864681 0.904864681 0.879264266 MMP3 1 hsa05166 Human T-cell leukemia virus 1 infection Jan-90 222/8378 0.911971073 0.911971073 0.879264266 NRP1 1 hsa05208 Chemical carcinogenesis - reactive oxygen species Jan-90 223/8378 0.912942456 0.912942456 0.879264266 PRKD1 1 hsa04024 cAMP signaling pathway Jan-90 225/8378 0.914853534 0.914853534 0.879264266 MYL9 1 hsa05010 Alzheimer disease Feb-90 384/8378 0.923047255 0.923047255 0.880756942 LRP1/AXIN2 2 hsa05022 Pathways of neurodegeneration - multiple diseases Feb-90 476/8378 0.967424647 0.967424647 0.91650756 SIGMAR1/AXIN2 2 hsa05014 Amyotrophic lateral sclerosis Jan-90 364/8378 0.982039872 0.982039872 0.923755311 SIGMAR1 1 hsa04740 Olfactory transduction Jan-90 439/8378 0.992331237 0.992331237 0.926862386 PRKG1 1